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Aliases for RASL12 Gene

Aliases for RASL12 Gene

  • RAS Like Family 12 2 3 5
  • Ras Family Member Ris 2 3
  • Ras-Like Protein Ris 3 4
  • RIS 3 4
  • Ras-Like Protein Family Member 12 3
  • RAS-Like, Family 12 2
  • RAS-Like Family 12 2

External Ids for RASL12 Gene

Previous GeneCards Identifiers for RASL12 Gene

  • GC15M063061
  • GC15M063132
  • GC15M065345
  • GC15M042170

Summaries for RASL12 Gene

GeneCards Summary for RASL12 Gene

RASL12 (RAS Like Family 12) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RERG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL12 Gene

Genomics for RASL12 Gene

Regulatory Elements for RASL12 Gene

Enhancers for RASL12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F065053 0.9 Ensembl ENCODE 12 +21.5 21512 2.4 ELF3 PKNOX1 ARID4B SIN3A ZNF48 ZSCAN9 RAD21 YY1 SCRT2 ZNF143 UBAP1L SPG21 MTFMT RASL12 KBTBD13 RNU5B-1 RBPMS2 MIR1272 ENSG00000277351 PIR51727
GH15F065052 0.9 FANTOM5 12 +24.3 24277 0.0 ZNF18 ZNF7 SP7 MTFMT RASL12 KBTBD13 UBAP1L MIR1272 ENSG00000277351 PIR51727
GH15F065048 0.2 ENCODE 12 +26.8 26804 1.9 HDAC1 ATF1 PKNOX1 SIN3A BMI1 ZBTB40 RFX5 EGR1 SCRT2 ZNF143 SPG21 UBAP1L MTFMT KBTBD13 RASL12 MIR1272 ANKDD1A ENSG00000277351 PIR51727
GH15F065101 0.5 Ensembl ENCODE 11.5 -25.4 -25398 1.5 CTCF HMG20B RNF2 ARID4B TRIM22 REST RAD21 ZNF366 HDAC2 SMC3 KBTBD13 RASL12 RNU5B-1 ENSG00000249240 PLEKHO2 ENSG00000259258 LOC105370862
GH15F065035 0.5 ENCODE 11.5 +39.8 39770 2.2 BCOR SMARCA5 ZNF362 ZNF280D ZMYM3 NFXL1 TBX21 BCL11B ZFHX2 HDAC2 KBTBD13 RASL12 UBAP1L RBPMS2 MTFMT SLC51B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RASL12 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASL12 Gene

Chromosome:
15
Start:
65,045,582 bp from pter
End:
65,076,690 bp from pter
Size:
31,109 bases
Orientation:
Minus strand

Genomic View for RASL12 Gene

Genes around RASL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL12 Gene

Proteins for RASL12 Gene

  • Protein details for RASL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYN1-RASLC_HUMAN
    Recommended name:
    Ras-like protein family member 12
    Protein Accession:
    Q9NYN1
    Secondary Accessions:
    • B2RC29
    • B4DJW2
    • B4DU82

    Protein attributes for RASL12 Gene

    Size:
    266 amino acids
    Molecular mass:
    29662 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RASL12 Gene

    Alternative splice isoforms for RASL12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASL12 Gene

Post-translational modifications for RASL12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASL12 Gene

No data available for DME Specific Peptides for RASL12 Gene

Domains & Families for RASL12 Gene

Gene Families for RASL12 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYN1

UniProtKB/Swiss-Prot:

RASLC_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL12: view

Function for RASL12 Gene

Gene Ontology (GO) - Molecular Function for RASL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL12: view
genes like me logo Genes that share phenotypes with RASL12: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASL12 Gene

Localization for RASL12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASL12 Gene COMPARTMENTS Subcellular localization image for RASL12 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RASL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASL12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASL12 Gene

Pathways & Interactions for RASL12 Gene

SuperPathways for RASL12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RASL12: view

No data available for Pathways by source and SIGNOR curated interactions for RASL12 Gene

Transcripts for RASL12 Gene

Unigene Clusters for RASL12 Gene

RAS-like, family 12:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASL12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for RASL12 Gene

GeneLoc Exon Structure for
RASL12
ECgene alternative splicing isoforms for
RASL12

Expression for RASL12 Gene

mRNA expression in normal human tissues for RASL12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASL12 Gene

This gene is overexpressed in Artery - Tibial (x8.8), Artery - Coronary (x4.5), and Artery - Aorta (x4.2).

Protein differential expression in normal tissues from HIPED for RASL12 Gene

This gene is overexpressed in Frontal cortex (35.4) and Prostate (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASL12 Gene



NURSA nuclear receptor signaling pathways regulating expression of RASL12 Gene:

RASL12

SOURCE GeneReport for Unigene cluster for RASL12 Gene:

Hs.27018
genes like me logo Genes that share expression patterns with RASL12: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RASL12 Gene

Orthologs for RASL12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASL12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASL12 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia RASL12 34 35
  • 91.27 (n)
cow
(Bos Taurus)
Mammalia RASL12 34 35
  • 90.35 (n)
mouse
(Mus musculus)
Mammalia Rasl12 34 16 35
  • 88.6 (n)
rat
(Rattus norvegicus)
Mammalia Rasl12 34
  • 88.35 (n)
oppossum
(Monodelphis domestica)
Mammalia RASL12 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASL12 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASL12 34 35
  • 75.54 (n)
lizard
(Anolis carolinensis)
Reptilia RASL12 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl12 34
  • 65.78 (n)
zebrafish
(Danio rerio)
Actinopterygii rasl12 34 35
  • 65.33 (n)
zgc63633 34
worm
(Caenorhabditis elegans)
Secernentea Y71F9AR.2 34 35
  • 49.07 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHB1 35
  • 25 (a)
OneToMany
Species where no ortholog for RASL12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASL12 Gene

ENSEMBL:
Gene Tree for RASL12 (if available)
TreeFam:
Gene Tree for RASL12 (if available)

Paralogs for RASL12 Gene

Paralogs for RASL12 Gene

genes like me logo Genes that share paralogs with RASL12: view

Variants for RASL12 Gene

Sequence variations from dbSNP and Humsavar for RASL12 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs200549195 Pathogenic 65,077,557(+) AGCCG(A/C/T)GCTAT upstream-variant-2KB, reference, missense
rs387907090 Pathogenic 65,078,037(+) TCAAC(A/C/T)GCATG upstream-variant-2KB, reference, missense
rs116406369 Likely benign 65,078,178(+) CGACA(A/G)CGGCA upstream-variant-2KB, reference, missense
rs199526404 Likely benign 65,077,892(+) AACGG(A/G)CCTTC upstream-variant-2KB, reference, synonymous-codon
rs202004658 Likely benign 65,077,003(+) GCTGC(A/T)GGTGC upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RASL12 Gene

Variant ID Type Subtype PubMed ID
esv2763104 CNV gain 21179565

Variation tolerance for RASL12 Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASL12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASL12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASL12 Gene

Disorders for RASL12 Gene

Relevant External Links for RASL12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASL12

No disorders were found for RASL12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASL12 Gene

Publications for RASL12 Gene

  1. Expressed sequence tag analysis of adult human iris for the NEIBank project: steroid-response factors and similarities with retinal pigment epithelium. (PMID: 12107412) Wistow G. … Peterson K. (Mol. Vis. 2002) 2 3 4 64
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for RASL12 Gene

Sources for RASL12 Gene

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