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Aliases for RASL12 Gene

Aliases for RASL12 Gene

  • RAS-Like, Family 12 2 3
  • Ras Family Member Ris 2 3
  • Ras-Like Protein Ris 3 4
  • RIS 3 4
  • Ras-Like Protein Family Member 12 3

External Ids for RASL12 Gene

Summaries for RASL12 Gene

GeneCards Summary for RASL12 Gene

RASL12 (RAS-Like, Family 12) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RERG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL12 Gene

Genomics for RASL12 Gene

Genomic Location for RASL12 Gene

Start:
65,045,673 bp from pter
End:
65,076,690 bp from pter
Size:
31,018 bases
Orientation:
Minus strand

Genomic View for RASL12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL12 Gene

Regulatory Elements for RASL12 Gene

Proteins for RASL12 Gene

  • Protein details for RASL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYN1-RASLC_HUMAN
    Recommended name:
    Ras-like protein family member 12
    Protein Accession:
    Q9NYN1
    Secondary Accessions:
    • B2RC29
    • B4DJW2
    • B4DU82

    Protein attributes for RASL12 Gene

    Size:
    266 amino acids
    Molecular mass:
    29662 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RASL12 Gene

    Alternative splice isoforms for RASL12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASL12 Gene

Proteomics data for RASL12 Gene at MOPED

Post-translational modifications for RASL12 Gene

No Post-translational modifications

Other Protein References for RASL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASL12 Gene

Domains for RASL12 Gene

UniProtKB/Swiss-Prot:

RASLC_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Ras family.:
    • Q9NYN1
genes like me logo Genes that share domains with RASL12: view

No data available for Gene Families for RASL12 Gene

Function for RASL12 Gene

Gene Ontology (GO) - Molecular Function for RASL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL12: view

Phenotypes for RASL12 Gene

genes like me logo Genes that share phenotypes with RASL12: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RASL12 Gene

Localization for RASL12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASL12 Gene COMPARTMENTS Subcellular localization image for RASL12 gene
Compartment Confidence
cytosol 2
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RASL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASL12: view

Pathways for RASL12 Gene

SuperPathways for RASL12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RASL12: view

No data available for Pathways by source for RASL12 Gene

Transcripts for RASL12 Gene

Unigene Clusters for RASL12 Gene

RAS-like, family 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASL12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for RASL12 Gene

GeneLoc Exon Structure for
RASL12
ECgene alternative splicing isoforms for
RASL12

Expression for RASL12 Gene

mRNA expression in normal human tissues for RASL12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASL12 Gene

This gene is overexpressed in Artery - Tibial (8.8), Artery - Coronary (4.5), and Artery - Aorta (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASL12 Gene

SOURCE GeneReport for Unigene cluster for RASL12 Gene Hs.27018

genes like me logo Genes that share expressions with RASL12: view

Orthologs for RASL12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASL12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASL12 36
  • 99.12 (n)
  • 99.25 (a)
RASL12 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASL12 36
  • 90.35 (n)
  • 93.61 (a)
RASL12 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASL12 36
  • 91.27 (n)
  • 93.56 (a)
RASL12 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasl12 36
  • 88.6 (n)
  • 93.61 (a)
Rasl12 16
Rasl12 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASL12 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASL12 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasl12 36
  • 88.35 (n)
  • 93.98 (a)
chicken
(Gallus gallus)
Aves RASL12 36
  • 75.54 (n)
  • 75.29 (a)
RASL12 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASL12 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl12 36
  • 65.78 (n)
  • 64.26 (a)
zebrafish
(Danio rerio)
Actinopterygii rasl12 36
  • 65.33 (n)
  • 69.08 (a)
rasl12 37
  • 66 (a)
OneToOne
zgc63633 36
worm
(Caenorhabditis elegans)
Secernentea Y71F9AR.2 36
  • 49.07 (n)
  • 40.99 (a)
Y71F9AR.2 37
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHB1 37
  • 25 (a)
OneToMany
Species with no ortholog for RASL12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASL12 Gene

ENSEMBL:
Gene Tree for RASL12 (if available)
TreeFam:
Gene Tree for RASL12 (if available)

Paralogs for RASL12 Gene

Paralogs for RASL12 Gene

Selected SIMAP similar genes for RASL12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RASL12: view

Variants for RASL12 Gene

Sequence variations from dbSNP and Humsavar for RASL12 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2232752 -- 65,068,783(-) GTGGG(C/T)CCTTT upstream-variant-2KB
rs2232753 -- 65,065,153(-) GGACC(C/T)ACCCC intron-variant
rs2232754 -- 65,065,096(-) AAGCC(A/G)CCAGG intron-variant
rs2232755 -- 65,065,072(-) TGGGG(A/G)AAAAT intron-variant
rs2232756 -- 65,059,316(-) GCACT(A/G)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASL12 Gene

Variant ID Type Subtype PubMed ID
nsv904308 CNV Loss 21882294

Relevant External Links for RASL12 Gene

HapMap Linkage Disequilibrium report
RASL12

Disorders for RASL12 Gene

No disorders were found for RASL12 Gene.

No data available for UniProtKB/Swiss-Prot for RASL12 Gene

Publications for RASL12 Gene

  1. Expressed sequence tag analysis of adult human iris for the NEIBank project: steroid-response factors and similarities with retinal pigment epithelium. (PMID: 12107412) Wistow G. … Peterson K. (Mol. Vis. 2002) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for RASL12 Gene

Sources for RASL12 Gene

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