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Aliases for RASL11B Gene

Aliases for RASL11B Gene

  • RAS Like Family 11 Member B 2 3 5
  • RAS-Like, Family 11, Member B 2
  • RAS-Like Family 11 Member B 2

External Ids for RASL11B Gene

Previous GeneCards Identifiers for RASL11B Gene

  • GC00U914304
  • GC04P053645
  • GC04P053569
  • GC04P053423
  • GC04P053728
  • GC04P049672

Summaries for RASL11B Gene

Entrez Gene Summary for RASL11B Gene

  • RASL11B is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]

GeneCards Summary for RASL11B Gene

RASL11B (RAS Like Family 11 Member B) is a Protein Coding gene. GO annotations related to this gene include GTP binding and ferrous iron transmembrane transporter activity. An important paralog of this gene is RASL11A.

Gene Wiki entry for RASL11B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL11B Gene

Genomics for RASL11B Gene

Regulatory Elements for RASL11B Gene

Enhancers for RASL11B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G052822 1.3 Ensembl ENCODE dbSUPER 10.8 -37.8 -37796 3.8 ELF3 SOX13 SAP130 ZNF175 BACH1 SIN3A RAD21 RARA TEAD3 FOSL1 ERVMER34-1 ENSG00000212490 RASL11B DANCR GC04P052827 LINC01618
GH04G052721 1.2 Ensembl ENCODE 10.1 -139.8 -139793 1.8 HDGF PKNOX1 AGO1 SIN3A BRCA1 YY1 GLIS2 ZNF143 FOS KLF7 ERVMER34-1 ENSG00000212490 USP46 RASL11B ENSG00000248375 GC04P052749
GH04G052911 0.9 Ensembl ENCODE 10.2 +49.6 49611 0.2 CTCF RFX1 REST ZNF644 RAD21 SMARCA4 SMC3 ZNF143 RASL11B LOC101928658 GC04M052884
GH04G052862 0.9 ENCODE 5.7 +0.5 515 2.0 TBP ATF1 CBX3 RB1 CREB3L1 KLF17 ETS1 GLIS2 EGR1 ZNF143 DANCR RASL11B PIR51358 GC04M052884
GH04G052841 0.9 Ensembl ENCODE dbSUPER 5.5 -20.2 -20196 0.6 REST RASL11B GC04P052827 GC04M052856
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASL11B on UCSC Golden Path with GeneCards custom track

Promoters for RASL11B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000168289 10 1001 TBP CBX3 RB1 CREB3L1 KLF17 ETS1 GLIS2 EGR1 ZNF143 EGR2

Genomic Location for RASL11B Gene

Chromosome:
4
Start:
52,862,290 bp from pter
End:
52,866,835 bp from pter
Size:
4,546 bases
Orientation:
Plus strand

Genomic View for RASL11B Gene

Genes around RASL11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASL11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASL11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL11B Gene

Proteins for RASL11B Gene

  • Protein details for RASL11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPW5-RSLBB_HUMAN
    Recommended name:
    Ras-like protein family member 11B
    Protein Accession:
    Q9BPW5
    Secondary Accessions:
    • B2RC51
    • Q96KC5

    Protein attributes for RASL11B Gene

    Size:
    248 amino acids
    Molecular mass:
    27508 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RASL11B Gene

Post-translational modifications for RASL11B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASL11B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASL11B Gene

Domains & Families for RASL11B Gene

Gene Families for RASL11B Gene

Suggested Antigen Peptide Sequences for RASL11B Gene

Graphical View of Domain Structure for InterPro Entry

Q9BPW5

UniProtKB/Swiss-Prot:

RSLBB_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL11B: view

Function for RASL11B Gene

Molecular function for RASL11B Gene

UniProtKB/Swiss-Prot Induction:
By TGFB1.

Gene Ontology (GO) - Molecular Function for RASL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005160 transforming growth factor beta receptor binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL11B: view
genes like me logo Genes that share phenotypes with RASL11B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASL11B Gene

Localization for RASL11B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASL11B gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RASL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASL11B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASL11B Gene

Pathways & Interactions for RASL11B Gene

SuperPathways for RASL11B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with RASL11B: view

No data available for Pathways by source and SIGNOR curated interactions for RASL11B Gene

Drugs & Compounds for RASL11B Gene

No Compound Related Data Available

Transcripts for RASL11B Gene

mRNA/cDNA for RASL11B Gene

Unigene Clusters for RASL11B Gene

RAS-like, family 11, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASL11B Gene

No ASD Table

Relevant External Links for RASL11B Gene

GeneLoc Exon Structure for
RASL11B
ECgene alternative splicing isoforms for
RASL11B

Expression for RASL11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASL11B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASL11B Gene

This gene is overexpressed in Ovary (x11.2) and Spleen (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of RASL11B Gene:

RASL11B

SOURCE GeneReport for Unigene cluster for RASL11B Gene:

Hs.8035

mRNA Expression by UniProt/SwissProt for RASL11B Gene:

Q9BPW5-RSLBB_HUMAN
Tissue specificity: Widely expressed with highest levels in placenta and primary macrophages.

Evidence on tissue expression from TISSUES for RASL11B Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with RASL11B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASL11B Gene

Orthologs for RASL11B Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL11B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASL11B 34 35
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia RASL11B 34 35
  • 89.65 (n)
dog
(Canis familiaris)
Mammalia RASL11B 34 35
  • 89.52 (n)
oppossum
(Monodelphis domestica)
Mammalia RASL11B 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasl11b 34
  • 87.58 (n)
mouse
(Mus musculus)
Mammalia Rasl11b 34 16 35
  • 86.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RASL11B 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASL11B 34 35
  • 78.56 (n)
lizard
(Anolis carolinensis)
Reptilia RASL11B 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl11b 34
  • 72.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53580 34
zebrafish
(Danio rerio)
Actinopterygii rasl11b 34 35
  • 66.1 (n)
zgc55750 34
fruit fly
(Drosophila melanogaster)
Insecta CG8519 35
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for RASL11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASL11B Gene

ENSEMBL:
Gene Tree for RASL11B (if available)
TreeFam:
Gene Tree for RASL11B (if available)

Paralogs for RASL11B Gene

Paralogs for RASL11B Gene

(20) SIMAP similar genes for RASL11B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASL11B: view

Variants for RASL11B Gene

Sequence variations from dbSNP and Humsavar for RASL11B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000144761 -- 52,862,193(+) CCTCC(C/G)GGGGC upstream-variant-2KB
rs1000512547 -- 52,864,301(+) ATAGG(A/G)TTAAA intron-variant
rs1000515006 -- 52,862,230(+) GCGGG(A/G)CCTCG upstream-variant-2KB
rs1001113898 -- 52,861,630(+) TTGTT(C/G)TATAA upstream-variant-2KB
rs1001172840 -- 52,862,124(+) CCCGC(C/G/T)GCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RASL11B Gene

Variant ID Type Subtype PubMed ID
dgv1000e214 CNV loss 21293372
nsv594201 CNV loss 21841781

Variation tolerance for RASL11B Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASL11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASL11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASL11B Gene

Disorders for RASL11B Gene

Relevant External Links for RASL11B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASL11B

No disorders were found for RASL11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASL11B Gene

Publications for RASL11B Gene

  1. Cloning, genomic organization, and tissue-specific expression of the RASL11B gene. (PMID: 17628721) Stolle K. … Lorkowski S. (Biochim. Biophys. Acta 2007) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors. (PMID: 15033445) Louro R. … Reis E.M. (Biochem. Biophys. Res. Commun. 2004) 3 4 64
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for RASL11B Gene

Sources for RASL11B Gene

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