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Aliases for RASL11A Gene

Aliases for RASL11A Gene

  • RAS-Like, Family 11, Member A 2 3

External Ids for RASL11A Gene

Summaries for RASL11A Gene

Entrez Gene Summary for RASL11A Gene

  • RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]

GeneCards Summary for RASL11A Gene

RASL11A (RAS-Like, Family 11, Member A) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot for RASL11A Gene

  • Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL11A Gene

Genomics for RASL11A Gene

Genomic Location for RASL11A Gene

Start:
27,270,327 bp from pter
End:
27,273,767 bp from pter
Size:
3,441 bases
Orientation:
Plus strand

Genomic View for RASL11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASL11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL11A Gene

Regulatory Elements for RASL11A Gene

Proteins for RASL11A Gene

  • Protein details for RASL11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6T310-RSLBA_HUMAN
    Recommended name:
    Ras-like protein family member 11A
    Protein Accession:
    Q6T310
    Secondary Accessions:
    • B2RN97

    Protein attributes for RASL11A Gene

    Size:
    242 amino acids
    Molecular mass:
    27006 Da
    Quaternary structure:
    • Interacts with UBF/UBTF.

neXtProt entry for RASL11A Gene

Proteomics data for RASL11A Gene at MOPED

Post-translational modifications for RASL11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASL11A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASL11A Gene

Domains for RASL11A Gene

UniProtKB/Swiss-Prot:

RSLBA_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Ras family.:
    • Q6T310
genes like me logo Genes that share domains with RASL11A: view

No data available for Gene Families for RASL11A Gene

Function for RASL11A Gene

Molecular function for RASL11A Gene

UniProtKB/Swiss-Prot Function: Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).
UniProtKB/Swiss-Prot Induction: Down-regulated by TGFB1.

Gene Ontology (GO) - Molecular Function for RASL11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL11A: view

Phenotypes for RASL11A Gene

GenomeRNAi human phenotypes for RASL11A:
genes like me logo Genes that share phenotypes with RASL11A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RASL11A Gene

Localization for RASL11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASL11A Gene

Nucleus, nucleolus. Note=Associates with rDNA transcription unit throughout the cell cycle. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASL11A Gene COMPARTMENTS Subcellular localization image for RASL11A gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RASL11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005730 nucleolus ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASL11A: view

Pathways for RASL11A Gene

SuperPathways for RASL11A Gene

No Data Available

Interacting Proteins for RASL11A Gene

Gene Ontology (GO) - Biological Process for RASL11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006351 transcription, DNA-templated IEA --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RASL11A: view

No data available for Pathways by source for RASL11A Gene

Transcripts for RASL11A Gene

mRNA/cDNA for RASL11A Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASL11A Gene

RAS-like, family 11, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASL11A Gene

No ASD Table

Relevant External Links for RASL11A Gene

GeneLoc Exon Structure for
RASL11A
ECgene alternative splicing isoforms for
RASL11A

Expression for RASL11A Gene

mRNA expression in normal human tissues for RASL11A Gene

SOURCE GeneReport for Unigene cluster for RASL11A Gene Hs.192131

mRNA Expression by UniProt/SwissProt for RASL11A Gene

Q6T310-RSLBA_HUMAN
Tissue specificity: Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells.
genes like me logo Genes that share expressions with RASL11A: view

Orthologs for RASL11A Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASL11A 36
  • 100 (n)
  • 100 (a)
RASL11A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASL11A 36
  • 85.28 (n)
  • 87.5 (a)
RASL11A 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASL11A 36
  • 89.67 (n)
  • 93.39 (a)
RASL11A 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasl11a 36
  • 85.12 (n)
  • 89.26 (a)
Rasl11a 16
Rasl11a 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASL11A 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASL11A 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasl11a 36
  • 82.46 (n)
  • 86.96 (a)
chicken
(Gallus gallus)
Aves RASL11A 36
  • 72.15 (n)
  • 68.4 (a)
RASL11A 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASL11A 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl11a 36
  • 71.17 (n)
  • 70.04 (a)
zebrafish
(Danio rerio)
Actinopterygii rasl11a 37
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006025 36
  • 55.21 (n)
  • 45.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8519 36
  • 54.78 (n)
  • 45.22 (a)
CG8519 37
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
OneToMany
Species with no ortholog for RASL11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASL11A Gene

ENSEMBL:
Gene Tree for RASL11A (if available)
TreeFam:
Gene Tree for RASL11A (if available)

Paralogs for RASL11A Gene

Paralogs for RASL11A Gene

Selected SIMAP similar genes for RASL11A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASL11A: view

Variants for RASL11A Gene

Sequence variations from dbSNP and Humsavar for RASL11A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs9507866 -- 27,271,147(+) GAGGG(A/C)GCCTC intron-variant, upstream-variant-2KB
rs9507867 -- 27,271,203(+) GCGCT(C/G)GGTGG intron-variant, utr-variant-5-prime
rs9512592 -- 27,271,411(+) CCCCC(C/G)AGTTT intron-variant
rs9581826 -- 27,272,209(+) tccta(A/G)gttcc intron-variant
rs9581828 -- 27,273,656(+) AGAAG(C/T)TGGAT utr-variant-3-prime

Relevant External Links for RASL11A Gene

HapMap Linkage Disequilibrium report
RASL11A

No data available for Structural Variations from Database of Genomic Variants (DGV) for RASL11A Gene

Disorders for RASL11A Gene

Relevant External Links for RASL11A

Genetic Association Database (GAD)
RASL11A
Human Genome Epidemiology (HuGE) Navigator
RASL11A
genes like me logo Genes that share disorders with RASL11A: view

No data available for UniProtKB/Swiss-Prot for RASL11A Gene

Publications for RASL11A Gene

  1. Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors. (PMID: 15033445) Louro R. … Reis E.M. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  3. Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a. (PMID: 20168301) Pistoni M. … Amati B. (EMBO J. 2010) 3
  4. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 49
  5. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PMID: 17903306) Newton-Cheh C. … Larson M.G. (BMC Med. Genet. 2007) 49

Products for RASL11A Gene

Sources for RASL11A Gene

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