Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RASL11A Gene

Aliases for RASL11A Gene

  • RAS Like Family 11 Member A 2 3 5
  • RAS-Like, Family 11, Member A 2
  • RAS-Like Family 11 Member A 2

External Ids for RASL11A Gene

Previous GeneCards Identifiers for RASL11A Gene

  • GC00U914303
  • GC13U900274
  • GC13P026742
  • GC13P027844
  • GC13P008666

Summaries for RASL11A Gene

Entrez Gene Summary for RASL11A Gene

  • RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]

GeneCards Summary for RASL11A Gene

RASL11A (RAS Like Family 11 Member A) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RASL11B.

UniProtKB/Swiss-Prot for RASL11A Gene

  • Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL11A Gene

Genomics for RASL11A Gene

Regulatory Elements for RASL11A Gene

Enhancers for RASL11A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G027042 1.3 Ensembl ENCODE dbSUPER 16 -227.3 -227278 1.4 PKNOX1 NFIB SIN3A RAD21 SCRT2 FOS RCOR1 ZEB2 PRDM6 IKZF1 RASL11A GC13P027043 RPS20P32
GH13G027053 1.3 Ensembl ENCODE dbSUPER 15.9 -215.9 -215850 2.2 SOX13 PKNOX1 FOXA2 NFIB SIN3A MAX ZIC2 ZFHX2 EGR1 FOS RASL11A LINC00412 RPL21 SNORA27 SNORD102 USP12 LOC105370124 GC13P027043
GH13G027361 1.1 Ensembl ENCODE 16.4 +92.0 92014 1.1 RB1 ZSCAN4 WRNIP1 SIN3A DMAP1 ZNF48 RAD21 ZNF143 CREM KDM4B RASL11A GSX1 SNORA27 SNORD102 RPL21 LINC01079 RNU6-70P
GH13G027952 1.6 FANTOM5 ENCODE dbSUPER 10.4 +685.1 685142 6.0 HDGF FOXA2 ARNT FEZF1 ZNF2 YY1 ZNF143 ZNF207 ZNF548 MCM5 CDX2 PAN3-AS1 PAN3 SNORA27 RPL21 PLUT PDX1 GSX1 RASL11A URAD
GH13G027034 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -234.0 -233953 3.5 SMARCC1 NRF1 ZMYM3 SIN3A ZNF16 ZIC2 NR2F2 FOSL1 JUND POLR2A RASL11A RNU6-70P WASF3 GPR12 GC13P027043 RPS20P32
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASL11A on UCSC Golden Path with GeneCards custom track

Promoters for RASL11A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000060315 573 1401 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 ZBTB7B YY1 GLIS2 ZNF143

Genomic Location for RASL11A Gene

Chromosome:
13
Start:
27,270,327 bp from pter
End:
27,273,767 bp from pter
Size:
3,441 bases
Orientation:
Plus strand

Genomic View for RASL11A Gene

Genes around RASL11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASL11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASL11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL11A Gene

Proteins for RASL11A Gene

  • Protein details for RASL11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6T310-RSLBA_HUMAN
    Recommended name:
    Ras-like protein family member 11A
    Protein Accession:
    Q6T310
    Secondary Accessions:
    • B2RN97

    Protein attributes for RASL11A Gene

    Size:
    242 amino acids
    Molecular mass:
    27006 Da
    Quaternary structure:
    • Interacts with UBF/UBTF.

neXtProt entry for RASL11A Gene

Post-translational modifications for RASL11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASL11A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASL11A Gene

Domains & Families for RASL11A Gene

Gene Families for RASL11A Gene

Suggested Antigen Peptide Sequences for RASL11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6T310

UniProtKB/Swiss-Prot:

RSLBA_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL11A: view

Function for RASL11A Gene

Molecular function for RASL11A Gene

UniProtKB/Swiss-Prot Function:
Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by TGFB1.

Gene Ontology (GO) - Molecular Function for RASL11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL11A: view
genes like me logo Genes that share phenotypes with RASL11A: view

Animal Model Products

CRISPR Products

miRNA for RASL11A Gene

miRTarBase miRNAs that target RASL11A

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASL11A Gene

Localization for RASL11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASL11A Gene

Nucleus, nucleolus. Note=Associates with rDNA transcription unit throughout the cell cycle. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASL11A gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RASL11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASL11A: view

Pathways & Interactions for RASL11A Gene

SuperPathways for RASL11A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASL11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0045943 positive regulation of transcription from RNA polymerase I promoter IEA,ISS --
genes like me logo Genes that share ontologies with RASL11A: view

No data available for Pathways by source and SIGNOR curated interactions for RASL11A Gene

Drugs & Compounds for RASL11A Gene

No Compound Related Data Available

Transcripts for RASL11A Gene

mRNA/cDNA for RASL11A Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASL11A Gene

RAS-like, family 11, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASL11A Gene

No ASD Table

Relevant External Links for RASL11A Gene

GeneLoc Exon Structure for
RASL11A
ECgene alternative splicing isoforms for
RASL11A

Expression for RASL11A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASL11A Gene

NURSA nuclear receptor signaling pathways regulating expression of RASL11A Gene:

RASL11A

SOURCE GeneReport for Unigene cluster for RASL11A Gene:

Hs.192131

mRNA Expression by UniProt/SwissProt for RASL11A Gene:

Q6T310-RSLBA_HUMAN
Tissue specificity: Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells.
genes like me logo Genes that share expression patterns with RASL11A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASL11A Gene

Orthologs for RASL11A Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASL11A 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia RASL11A 34 35
  • 89.67 (n)
cow
(Bos Taurus)
Mammalia RASL11A 34 35
  • 85.28 (n)
mouse
(Mus musculus)
Mammalia Rasl11a 34 16 35
  • 85.12 (n)
oppossum
(Monodelphis domestica)
Mammalia RASL11A 35
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasl11a 34
  • 82.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RASL11A 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASL11A 34 35
  • 72.15 (n)
lizard
(Anolis carolinensis)
Reptilia RASL11A 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl11a 34
  • 71.17 (n)
zebrafish
(Danio rerio)
Actinopterygii rasl11a 35
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006025 34
  • 55.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8519 34 35
  • 54.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for RASL11A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASL11A Gene

ENSEMBL:
Gene Tree for RASL11A (if available)
TreeFam:
Gene Tree for RASL11A (if available)

Paralogs for RASL11A Gene

Paralogs for RASL11A Gene

(21) SIMAP similar genes for RASL11A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASL11A: view

Variants for RASL11A Gene

Sequence variations from dbSNP and Humsavar for RASL11A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000477741 -- 27,270,617(+) GAGCC(C/T)CGGAG upstream-variant-2KB, utr-variant-5-prime
rs1001001285 -- 27,268,476(+) TTCTC(C/T)AAGGG upstream-variant-2KB
rs1001033161 -- 27,268,577(+) CGGTG(C/G)CTCAC upstream-variant-2KB
rs1002067881 -- 27,268,583(+) CTCAC(A/G)CCTGT upstream-variant-2KB
rs1002454162 -- 27,270,584(+) GCGCT(C/G)TGGAC upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for RASL11A Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASL11A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASL11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RASL11A Gene

Disorders for RASL11A Gene

Relevant External Links for RASL11A

Genetic Association Database (GAD)
RASL11A
Human Genome Epidemiology (HuGE) Navigator
RASL11A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASL11A

No disorders were found for RASL11A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASL11A Gene

Publications for RASL11A Gene

  1. Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors. (PMID: 15033445) Louro R. … Reis E.M. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 64
  2. A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. (PMID: 21529783) Heath A.C. … Montgomery G.W. (Biol. Psychiatry 2011) 46 64
  3. Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a. (PMID: 20168301) Pistoni M. … Amati B. (EMBO J. 2010) 3 64
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 46 64

Products for RASL11A Gene

Sources for RASL11A Gene

Content
Loading form....