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Aliases for RASL11A Gene

Aliases for RASL11A Gene

  • RAS Like Family 11 Member A 2 3
  • RAS-Like Family 11 Member A 2 5
  • RAS-Like, Family 11, Member A 2

External Ids for RASL11A Gene

Previous GeneCards Identifiers for RASL11A Gene

  • GC00U914303
  • GC13U900274
  • GC13P026742
  • GC13P027844
  • GC13P008666

Summaries for RASL11A Gene

Entrez Gene Summary for RASL11A Gene

  • RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]

GeneCards Summary for RASL11A Gene

RASL11A (RAS Like Family 11 Member A) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot for RASL11A Gene

  • Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL11A Gene

Genomics for RASL11A Gene

Regulatory Elements for RASL11A Gene

Enhancers for RASL11A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RASL11A on UCSC Golden Path with GeneCards custom track

Promoters for RASL11A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASL11A on UCSC Golden Path with GeneCards custom track

Genomic Location for RASL11A Gene

27,270,327 bp from pter
27,273,767 bp from pter
3,441 bases
Plus strand

Genomic View for RASL11A Gene

Genes around RASL11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASL11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASL11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL11A Gene

Proteins for RASL11A Gene

  • Protein details for RASL11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-like protein family member 11A
    Protein Accession:
    Secondary Accessions:
    • B2RN97

    Protein attributes for RASL11A Gene

    242 amino acids
    Molecular mass:
    27006 Da
    Quaternary structure:
    • Interacts with UBF/UBTF.

neXtProt entry for RASL11A Gene

Proteomics data for RASL11A Gene at MOPED

Post-translational modifications for RASL11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASL11A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASL11A Gene

Domains & Families for RASL11A Gene

Gene Families for RASL11A Gene

Suggested Antigen Peptide Sequences for RASL11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL11A: view

Function for RASL11A Gene

Molecular function for RASL11A Gene

UniProtKB/Swiss-Prot Function:
Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by TGFB1.
genes like me logo Genes that share phenotypes with RASL11A: view

Animal Model Products

CRISPR Products

miRNA for RASL11A Gene

miRTarBase miRNAs that target RASL11A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASL11A Gene

Localization for RASL11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASL11A Gene

Nucleus, nucleolus. Note=Associates with rDNA transcription unit throughout the cell cycle. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RASL11A Gene COMPARTMENTS Subcellular localization image for RASL11A gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RASL11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RASL11A: view

Pathways & Interactions for RASL11A Gene

SuperPathways for RASL11A Gene

No Data Available

Interacting Proteins for RASL11A Gene

Gene Ontology (GO) - Biological Process for RASL11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RASL11A: view

No data available for Pathways by source and SIGNOR curated interactions for RASL11A Gene

Drugs & Compounds for RASL11A Gene

No Compound Related Data Available

Transcripts for RASL11A Gene

mRNA/cDNA for RASL11A Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASL11A Gene

RAS-like, family 11, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASL11A Gene

No ASD Table

Relevant External Links for RASL11A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASL11A Gene

mRNA expression in normal human tissues for RASL11A Gene

SOURCE GeneReport for Unigene cluster for RASL11A Gene Hs.192131

mRNA Expression by UniProt/SwissProt for RASL11A Gene

Tissue specificity: Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells.
genes like me logo Genes that share expression patterns with RASL11A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RASL11A Gene

Orthologs for RASL11A Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL11A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASL11A 35
  • 85.28 (n)
  • 87.5 (a)
RASL11A 36
  • 85 (a)
(Canis familiaris)
Mammalia RASL11A 35
  • 89.67 (n)
  • 93.39 (a)
RASL11A 36
  • 93 (a)
(Mus musculus)
Mammalia Rasl11a 35
  • 85.12 (n)
  • 89.26 (a)
Rasl11a 16
Rasl11a 36
  • 89 (a)
(Pan troglodytes)
Mammalia RASL11A 35
  • 100 (n)
  • 100 (a)
RASL11A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rasl11a 35
  • 82.46 (n)
  • 86.96 (a)
(Monodelphis domestica)
Mammalia RASL11A 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia RASL11A 36
  • 67 (a)
(Gallus gallus)
Aves RASL11A 35
  • 72.15 (n)
  • 68.4 (a)
RASL11A 36
  • 67 (a)
(Anolis carolinensis)
Reptilia RASL11A 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl11a 35
  • 71.17 (n)
  • 70.04 (a)
(Danio rerio)
Actinopterygii rasl11a 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006025 35
  • 55.21 (n)
  • 45.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8519 35
  • 54.78 (n)
  • 45.22 (a)
CG8519 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for RASL11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASL11A Gene

Gene Tree for RASL11A (if available)
Gene Tree for RASL11A (if available)

Paralogs for RASL11A Gene

Paralogs for RASL11A Gene

(21) SIMAP similar genes for RASL11A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASL11A: view

Variants for RASL11A Gene

Sequence variations from dbSNP and Humsavar for RASL11A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs7331765 -- 27,270,556(+) GCAGA(A/G)TGCCT upstream-variant-2KB, utr-variant-5-prime
rs9507866 -- 27,271,147(+) GAGGG(A/C)GCCTC intron-variant, upstream-variant-2KB
rs9507867 -- 27,271,203(+) GCGCT(C/G)GGTGG intron-variant, utr-variant-5-prime
rs9512592 -- 27,271,411(+) CCCCC(C/G)AGTTT intron-variant
rs11304490 -- 27,273,720(+) TTTTT(-/T)ACTGT downstream-variant-500B, utr-variant-3-prime

Variation tolerance for RASL11A Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RASL11A Gene

Disorders for RASL11A Gene

Relevant External Links for RASL11A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RASL11A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASL11A Gene

Publications for RASL11A Gene

  1. Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors. (PMID: 15033445) Louro R. … Reis E.M. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a. (PMID: 20168301) Pistoni M. … Amati B. (EMBO J. 2010) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RASL11A Gene

Sources for RASL11A Gene