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RASL11A Gene

protein-coding   GIFtS: 47
GCID: GC13P027844

RAS-Like, Family 11, Member A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAS-Like, Family 11, Member A1 2
Ras-Like Protein Family Member 11A2

External Ids:    HGNC: 238021   Entrez Gene: 3874962   Ensembl: ENSG000001220357   OMIM: 6124035   UniProtKB: Q6T3103   

Export aliases for RASL11A gene to outside databases

Previous GC identifers: GC00U914303 GC13U900274 GC13P026742 GC13P008666


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RASL11A Gene:
RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM
190020) proteins.(supplied by OMIM, Nov 2008)

GeneCards Summary for RASL11A Gene:
RASL11A (RAS-like, family 11, member A) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot: RSLBA_HUMAN, Q6T310
Function: Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I
transcription (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASL11A gene promoter:
         FOXF2   ATF-2   STAT5A   E4BP4   c-Ets-1   CRE-BP1   FOXO4   ARP-1   Msx-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASL11A promoter sequence
   Search Chromatin IP Primers for RASL11A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASL11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.2   Ensembl cytogenetic band:  13q12.2   HGNC cytogenetic band: 13q12.2

RASL11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASL11A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P027844:  view genomic region     (about GC identifiers)

Start:
27,844,464 bp from pter      End:
27,847,827 bp from pter
Size:
3,364 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RSLBA_HUMAN, Q6T310 (See protein sequence)
Recommended Name: Ras-like protein family member 11A  
Size: 242 amino acids; 27006 Da
Subunit: Interacts with UBF/UBTF (By similarity)
Developmental stage: Down-regulated during development of THP-1 monocytes into macrophages
Caution: Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which
serves to target Ras proteins to membrane compartments
Secondary accessions: B2RN97

Explore the universe of human proteins at neXtProt for RASL11A: NX_Q6T310

Explore proteomics data for RASL11A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASL11A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_996563.1  
    ENSEMBL proteins: 
     ENSP00000241463  

    RASL11A Human Recombinant Protein Products:

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    antibodies-online peptides for RASL11A

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    antibodies-online antibodies for RASL11A (3 products) 

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    antibodies-online kits for RASL11A (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q6T310

    ProtoNet protein and cluster: Q6T310

    3 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RSLBA_HUMAN, Q6T310
    Similarity: Belongs to the small GTPase superfamily. Ras family


    Find genes that share domains with RASL11A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSLBA_HUMAN, Q6T310
    Function: Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I
    transcription (By similarity)
    Induction: Down-regulated by TGFB1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RASL11A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RASL11A:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RASL11A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RSLBA_HUMAN, Q6T310: Nucleus, nucleolus (By similarity). Note=Associates with rDNA transcription unit throughout
    the cell cycle (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005730nucleolus ISS--
    GO:0016020membrane IEA--

    Find genes that share ontologies with RASL11A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASL11A
    Interactions:

        Search GeneGlobe Interaction Network for RASL11A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for RASL11A (Q6T3103 ENSP000002414634) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCLP193383, ENSP000003181954I2D: score=1 STRING: ENSP00000318195
    UBTFP174803, ENSP000003026404I2D: score=1 STRING: ENSP00000302640
    NPM1P067483, ENSP000002969304I2D: score=1 STRING: ENSP00000296930
    FBLENSP000002218014STRING: ENSP00000221801
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    Find genes that share ontologies with RASL11A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASL11A (RSLBA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RASL11A gene: 
    NM_206827.1  

    Unigene Cluster for RASL11A:

    RAS-like, family 11, member A
    Hs.192131  [show with all ESTs]
    Unigene Representative Sequence: NM_206827
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000241463(uc001urd.1) ENST00000475647 ENST00000480803
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RASL11A
      QuantiFast Probe-based Assays in human, mouse, rat RASL11A

    Additional mRNA sequence: 

    AY439004.1 BC132703.1 BC136761.1 

    2 DOTS entries:

    DT.431140  DT.40206261 

    7 AceView cDNA sequences:

    AY439004 NM_206827 CA421903 BM930528 BM846104 BM696152 BQ189455 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASL11A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATTTCTG
    RASL11A Expression
    About this image

    RASL11A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASL11A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.192131

    UniProtKB/Swiss-Prot: RSLBA_HUMAN, Q6T310
    Tissue specificity: Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High
    levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder
    and aorta. Lowest levels observed in endothelial cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASL11A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasl11a1 , 5 RAS-like, family 11, member A1, 5 85.12(n)1
    89.26(a)1
      5 (86.56 cM)5
    688951  NM_026864.11  NP_081140.11 
     1468450715 
    chicken
    (Gallus gallus)
    Aves RASL11A1 RAS-like, family 11, member A 72.15(n)
    68.4(a)
      418932  XM_417126.4  XP_417126.2 
    lizard
    (Anolis carolinensis)
    Reptilia RASL11A6
    RAS-like, family 11, member A
    73(a)
    1 ↔ 1
    GL343306.1(1067313-1072088)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rasl11a1 RAS-like, family 11, member A 71.17(n)
    70.04(a)
      100494021  XM_002941535.2  XP_002941581.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rasl11a6
    RAS-like, family 11, member A
    53(a)
    1 ↔ 1
    7(52769914-52776274) ENSDARG00000046013
    fruit fly
    (Drosophila melanogaster)
    Insecta CG85191 CG8519 54.78(n)
    45.22(a)
      38745  NM_139797.4  NP_648054.2 


    ENSEMBL Gene Tree for RASL11A (if available)
    TreeFam Gene Tree for RASL11A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASL11A gene
    RASL122  RERGL2  RHEB2  RASL11B2  RHEBL12  RERG2  
    Selected SIMAP similar genes for RASL11A using alignment to 1 protein entry:     RSLBA_HUMAN(see all similar genes):
    RASL11B    RERG    RAP2A    RAP2C    RAP2B    RHEBL1
    RALB    DIRAS2    HRAS    NRAS    RALA    RERGL
    KRAS    RIT2    RRAS2    MRAS    RHEB    RAP1B

    Find genes that share paralogs with RASL11A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASL11A (see all 135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480911431,2
    --27842472(+) TCACAA/GGCTAG 1 -- us2k10--------
    rs1418256381,2
    C--27842643(+) TCACCA/CTCTAG 1 -- us2k10--------
    rs1824271191,2
    --27842710(+) GGCGCA/GGTGGC 1 -- us2k10--------
    rs1506425511,2
    --27842736(+) CAGCAC/TTTTGG 1 -- us2k10--------
    rs2013666091,2
    C--27843000(-) CATTTC/TTTTTT 1 -- us2k10--------
    rs2015386991,2
    C--27843003(+) AAGAA-/ATGAGAGC 1 -- us2k10--------
    rs757971361,2
    --27843045(+) ATATAC/GGAGGA 1 -- us2k10--------
    rs1869902331,2
    C--27843094(+) AGAGAA/G/TTGGGT 1 -- us2k10--------
    rs780112501,2
    C,F--27843096(+) AGAGTG/AGGTAG 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1447137651,2
    --27843121(+) CCCAGG/TCTTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RASL11A (27844464 - 27847827 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RASL11A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASL11A
    DNA2.0 Custom Variant and Variant Library Synthesis for RASL11A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612403    OMIM disorders: --


    Find genes that share disorders with RASL11A           About GenesLikeMe

    Genetic Association Database (GAD): RASL11A
    Human Genome Epidemiology (HuGE) Navigator: RASL11A (1 document)

    Export disorders for RASL11A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASL11A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with RASL11A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors. (PubMed id 15033445)1, 2, 3 Louro R.... Reis E.M. (Biochem. Biophys. Res. Commun. 2004)
    2. A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. (PubMed id 21529783)4 Heath A.C....Montgomery G.W. (Biol. Psychiatry 2011)
    3. Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a. (PubMed id 20168301)1 Pistoni M....Amati B. (EMBO J. 2010)
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    5. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    6. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    7. Cloning, genomic organization, and tissue-specific expression of the RASL11B gene. (PubMed id 17628721)2 Stolle K....Lorkowski S. (Biochim. Biophys. Acta 2007)
    8. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 387496 HGNC: 23802 AceView: RASL11A Ensembl:ENSG00000122035 euGenes: HUgn387496
    ECgene: RASL11A H-InvDB: RASL11A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RASL11A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RASL11A gene:
    Search GeneIP for patents involving RASL11A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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