RASL10B Gene
protein-coding GIFtS: 44
GCID: GC17P034058
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RAS-like, family 10, member B
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Aliases
for RASL10B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAS-Like, Family 10, Member B1 2 | | RRP171 2 3 5 | | VTS586351 2 | | Ras-Like Protein VTS586352 3 | | Ras-Related Protein 172 3 | | Ras-Like Protein Family Member 10B2 |
Export aliases for RASL10B gene to outside databasesPrevious GC identifers: GC17P034204 GC17P031082 GC17P030243 |
Summaries
for RASL10B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RSLAB_HUMAN, Q96S79Function: May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in theregulation of arterial pressure (By similarity)
|
Genomic Views
for RASL10B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RASL10B gene promoter:
STAT1 FOXD3 STAT1beta HNF-3beta Tal-1beta STAT1alpha CREB deltaCREB ITF-2 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for RASL10B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASL10B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21.1RASL10B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P034058: view genomic region
(about GC identifiers)
Start:
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34,058,668 bp from pter |
End:
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34,070,540 bp from pter |
Size:
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11,873 bases |
Orientation:
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plus strand |
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Proteins
for RASL10B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RSLAB_HUMAN, Q96S79 (See
protein sequence)Recommended Name: Ras-like protein family member 10B precursor Size: 203 amino acids; 23229 Da
Subunit: Interacts with CADPS (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: B3KV31Explore the universe of human proteins at neXtProt for RASL10B: NX_Q96S79
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96S79
RASL10B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_201572.1
ENSEMBL proteins: ENSP00000268864
Human Recombinant Protein Products for RASL10B:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- |
RASL10B for ontologies About GeneDecksing
RASL10B Antibody Products:
Assay Products for RASL10B: |
Protein
Domains /
Families
for RASL10B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RASL10B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96S79ProtoNet protein and cluster: Q96S79 2 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB013684 Miro-like
UniProtKB/Swiss-Prot: RSLAB_HUMAN, Q96S79Similarity: Belongs to the small GTPase superfamily. Ras family |
Function
for RASL10B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RSLAB_HUMAN, Q96S79Function: May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in theregulation of arterial pressure (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RASL10B for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for RASL10B:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Rasl10b):
RASL10B for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Rasl10btm1Eno for RASL10B
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASL10B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASL10B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for RASL10B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASL10B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASL10B |
|
Pathways & Interactions
for RASL10B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASL10B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/12 Interacting proteins for RASL10B (ENSP000002688644) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003050 | regulation of systemic arterial blood pressure by atrial natriuretic peptide |
ISS | -- | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0090277 | positive regulation of peptide hormone secretion |
ISS | -- |
RASL10B for ontologies About GeneDecksing
|
Drugs & Compounds
for RASL10B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RASL10B
Search CenterWatch for drugs/clinical trials and news about RASL10B / RSLAB
|
Transcripts
for RASL10B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RASL10B gene: NM_033315.3 Unigene Cluster for RASL10B: RAS-like, family 10, member B Hs.437035 [show with all ESTs]Unigene Representative Sequence: NM_0333152 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000268864(uc002hju.3) ENST00000587350
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASL10B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASL10B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RASL10B (NM_033315) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RASL10B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASL10B |
Additional cDNA sequence: AB047296.1 AK122652.1 BC041133.1 2 DOTS entries: DT.95365501 DT.75100768 24/60 AceView cDNA sequences (see all 60): AI887398 BM708024 NM_033315 BP333947 AB047296 BU540583 BM671709 BC041133 BM704568 CR602996 BX115083 BQ066955 AI500182 BU678126 BU146573 AA454603 CD106926 BE790556 BU731424 BQ437507 AK122652 AI914006 AA432287 BQ068169
GeneLoc Exon Structure
|
Expression
for RASL10B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RASL10B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCATCACC
About this image
See RASL10B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RASL10B
SOURCE GeneReport for Unigene cluster: Hs.437035
UniProtKB/Swiss-Prot: RSLAB_HUMAN, Q96S79Tissue specificity: Expressed at high levels in skeletal muscle and, at much lower levels, in heart, brain and pancreas
SABiosciences Custom PCR Arrays for RASL10B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASL10B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RASL10B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASL10B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASL10B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASL10B |
Orthologs
for RASL10B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RASL10B gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for RASL10B (if available)
TreeFam Gene Tree for RASL10B (if available) |
Paralogs
for RASL10B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RASL10B gene
- RAP2C2 DIRAS12 RAP1B2 RASD22 RAP2A2 RAP1A2 RAP2B2 RASD12
- DIRAS22 RASL10A2 DIRAS32
6 SIMAP similar genes for RASL10B using alignment to 2 protein entries: RSLAB_HUMAN (see all proteins):RASL10A RAP1B RAP1A DIRAS2 RAP2B RAP2A
RASL10B for paralogs About GeneDecksing
|
Genomic Variants
for RASL10B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RASL10B (34058668 - 34070540 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RASL10B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RASL10B |
|
Disorders
/ Diseases
for RASL10B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RASL10B for disorders About MalaCards
RASL10B for disorders About GeneDecksing
OMIM gene information: 612128
OMIM disorders: --
Export disorders for RASL10B gene to outside databases
|
Publications
for RASL10B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RASL10B gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with RASL10B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. (PubMed id 17984325)1, 2 Rybkin I.I....Olson E.N. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential. (PubMed id 17028781)1 Zou H....Cao K. (2006)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
|
External Searches for RASL10B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RASL10B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RASL10B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RASL10B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RASL10B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RASL10B gene:
Search GeneIP for patents involving RASL10B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RASL10B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RASL10B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RASL10B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASL10B | | | OriGene Protein Over-expression Lysate for RASL10B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RASL10B | | OriGene 3'-UTR Clone for RASL10B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASL10B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASL10B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RASL10B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RASL10B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASL10B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASL10B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASL10B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASL10B |
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 | | | RASL10B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASL10B |
|  |  |  |  | | | | ThermoFisher Antibodies for RASL10B |
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