Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RASL10B Gene

Aliases for RASL10B Gene

  • RAS Like Family 10 Member B 2 3
  • RAS-Like Family 10 Member B 2 3 5
  • RAS-Like, Family 10, Member B 2 3
  • Ras-Like Protein VTS58635 3 4
  • Ras-Related Protein 17 3 4
  • RRP17 3 4
  • VTS58635 3

External Ids for RASL10B Gene

Previous GeneCards Identifiers for RASL10B Gene

  • GC17P034204
  • GC17P031082
  • GC17P034058
  • GC17P030243

Summaries for RASL10B Gene

GeneCards Summary for RASL10B Gene

RASL10B (RAS Like Family 10 Member B) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RASL10A.

UniProtKB/Swiss-Prot for RASL10B Gene

  • May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL10B Gene

Genomics for RASL10B Gene

Regulatory Elements for RASL10B Gene

Promoters for RASL10B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASL10B on UCSC Golden Path with GeneCards custom track

Genomic Location for RASL10B Gene

Chromosome:
17
Start:
35,731,649 bp from pter
End:
35,743,525 bp from pter
Size:
11,877 bases
Orientation:
Plus strand

Genomic View for RASL10B Gene

Genes around RASL10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASL10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASL10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL10B Gene

Proteins for RASL10B Gene

  • Protein details for RASL10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S79-RSLAB_HUMAN
    Recommended name:
    Ras-like protein family member 10B
    Protein Accession:
    Q96S79
    Secondary Accessions:
    • B3KV31

    Protein attributes for RASL10B Gene

    Size:
    203 amino acids
    Molecular mass:
    23229 Da
    Quaternary structure:
    • Interacts with CADPS.

neXtProt entry for RASL10B Gene

Proteomics data for RASL10B Gene at MOPED

Post-translational modifications for RASL10B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASL10B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RASL10B Gene

Domains & Families for RASL10B Gene

Gene Families for RASL10B Gene

Protein Domains for RASL10B Gene

Suggested Antigen Peptide Sequences for RASL10B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S79

UniProtKB/Swiss-Prot:

RSLAB_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL10B: view

Function for RASL10B Gene

Molecular function for RASL10B Gene

UniProtKB/Swiss-Prot Function:
May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.

Gene Ontology (GO) - Molecular Function for RASL10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with RASL10B: view
genes like me logo Genes that share phenotypes with RASL10B: view

Animal Models for RASL10B Gene

MGI Knock Outs for RASL10B:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASL10B Gene

Localization for RASL10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASL10B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASL10B Gene COMPARTMENTS Subcellular localization image for RASL10B gene
Compartment Confidence
plasma membrane 3
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for RASL10B Gene

Pathways & Interactions for RASL10B Gene

SuperPathways for RASL10B Gene

No Data Available

Interacting Proteins for RASL10B Gene

Gene Ontology (GO) - Biological Process for RASL10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090277 positive regulation of peptide hormone secretion IEA,ISS --
genes like me logo Genes that share ontologies with RASL10B: view

No data available for Pathways by source and SIGNOR curated interactions for RASL10B Gene

Drugs & Compounds for RASL10B Gene

No Compound Related Data Available

Transcripts for RASL10B Gene

mRNA/cDNA for RASL10B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(60) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASL10B Gene

RAS-like, family 10, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASL10B Gene

No ASD Table

Relevant External Links for RASL10B Gene

GeneLoc Exon Structure for
RASL10B
ECgene alternative splicing isoforms for
RASL10B

Expression for RASL10B Gene

mRNA expression in normal human tissues for RASL10B Gene

mRNA differential expression in normal tissues according to GTEx for RASL10B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.1) and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for RASL10B Gene

This gene is overexpressed in CD8 Tcells (35.9), Blymphocyte (21.7), and Lung (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASL10B Gene



SOURCE GeneReport for Unigene cluster for RASL10B Gene Hs.744994

mRNA Expression by UniProt/SwissProt for RASL10B Gene

Q96S79-RSLAB_HUMAN
Tissue specificity: Expressed at high levels in skeletal muscle and, at much lower levels, in heart, brain and pancreas.
genes like me logo Genes that share expression patterns with RASL10B: view

Protein tissue co-expression partners for RASL10B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RASL10B Gene

Orthologs for RASL10B Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL10B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASL10B 35
  • 96.39 (n)
  • 99.51 (a)
dog
(Canis familiaris)
Mammalia RASL10B 35
  • 95.73 (n)
  • 98.52 (a)
mouse
(Mus musculus)
Mammalia Rasl10b 35
  • 93.76 (n)
  • 99.01 (a)
Rasl10b 16
chimpanzee
(Pan troglodytes)
Mammalia RASL10B 35
  • 99.51 (n)
  • 99.51 (a)
rat
(Rattus norvegicus)
Mammalia LOC100912246 35
  • 94.25 (n)
  • 99.51 (a)
chicken
(Gallus gallus)
Aves RASL10B 35
  • 85.39 (n)
  • 91.63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl10b 35
  • 77.18 (n)
  • 87.68 (a)
zebrafish
(Danio rerio)
Actinopterygii rasl10a 35
  • 63.88 (n)
  • 61.08 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002563 35
  • 50.17 (n)
  • 39.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14669 35
  • 52.5 (n)
  • 42.51 (a)
Species with no ortholog for RASL10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASL10B Gene

ENSEMBL:
Gene Tree for RASL10B (if available)
TreeFam:
Gene Tree for RASL10B (if available)

Paralogs for RASL10B Gene

Paralogs for RASL10B Gene

(6) SIMAP similar genes for RASL10B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASL10B: view

Variants for RASL10B Gene

Sequence variations from dbSNP and Humsavar for RASL10B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_036309 A breast cancer sample
rs178940 -- 35,735,667(-) CCATA(A/T)ATTTT intron-variant
rs226417 -- 35,743,264(-) CCCCC(C/T)CACCC nc-transcript-variant, utr-variant-3-prime
rs226418 -- 35,742,974(-) GCTAC(C/G)CCCCA nc-transcript-variant, utr-variant-3-prime
rs226419 -- 35,739,538(+) TTGAG(A/T)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASL10B Gene

Variant ID Type Subtype PubMed ID
nsv908080 CNV Loss 21882294

Variation tolerance for RASL10B Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASL10B Gene

HapMap Linkage Disequilibrium report
RASL10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASL10B Gene

Disorders for RASL10B Gene

Relevant External Links for RASL10B

Genetic Association Database (GAD)
RASL10B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASL10B

No disorders were found for RASL10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASL10B Gene

Publications for RASL10B Gene

  1. Regulation of atrial natriuretic peptide secretion by a novel Ras- like protein. (PMID: 17984325) Rybkin I.I. … Olson E.N. (J. Cell Biol. 2007) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for RASL10B Gene

Sources for RASL10B Gene

Back to Top

Content