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Aliases for RASL10B Gene

Aliases for RASL10B Gene

  • RAS-Like, Family 10, Member B 2 3
  • RRP17 3 4 6
  • Ras-Like Protein VTS58635 3 4
  • Ras-Related Protein 17 3 4
  • Ras-Like Protein Family Member 10B 3
  • VTS58635 3

External Ids for RASL10B Gene

Previous GeneCards Identifiers for RASL10B Gene

  • GC17P034204
  • GC17P031082
  • GC17P034058
  • GC17P030243

Summaries for RASL10B Gene

GeneCards Summary for RASL10B Gene

RASL10B (RAS-Like, Family 10, Member B) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for RASL10B Gene

  • May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL10B Gene

Genomics for RASL10B Gene

Regulatory Elements for RASL10B Gene

Genomic Location for RASL10B Gene

Start:
35,731,649 bp from pter
End:
35,743,521 bp from pter
Size:
11,873 bases
Orientation:
Plus strand

Genomic View for RASL10B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASL10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL10B Gene

Proteins for RASL10B Gene

  • Protein details for RASL10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S79-RSLAB_HUMAN
    Recommended name:
    Ras-like protein family member 10B
    Protein Accession:
    Q96S79
    Secondary Accessions:
    • B3KV31

    Protein attributes for RASL10B Gene

    Size:
    203 amino acids
    Molecular mass:
    23229 Da
    Quaternary structure:
    • Interacts with CADPS.

neXtProt entry for RASL10B Gene

Proteomics data for RASL10B Gene at MOPED

Post-translational modifications for RASL10B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASL10B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASL10B Gene

Domains for RASL10B Gene

Protein Domains for RASL10B Gene

Suggested Antigen Peptide Sequences for RASL10B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S79

UniProtKB/Swiss-Prot:

RSLAB_HUMAN :
  • Q96S79
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL10B: view

No data available for Gene Families for RASL10B Gene

Function for RASL10B Gene

Molecular function for RASL10B Gene

UniProtKB/Swiss-Prot Function: May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.

Gene Ontology (GO) - Molecular Function for RASL10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL10B: view

Phenotypes for RASL10B Gene

MGI mutant phenotypes for RASL10B:
inferred from 1 alleles
GenomeRNAi human phenotypes for RASL10B:
genes like me logo Genes that share phenotypes with RASL10B: view

Animal Models for RASL10B Gene

MGI Knock Outs for RASL10B:

miRNA for RASL10B Gene

miRTarBase miRNAs that target RASL10B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RASL10B Gene

Localization for RASL10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASL10B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASL10B Gene COMPARTMENTS Subcellular localization image for RASL10B gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RASL10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RASL10B: view

Pathways for RASL10B Gene

SuperPathways for RASL10B Gene

No Data Available

Interacting Proteins for RASL10B Gene

Gene Ontology (GO) - Biological Process for RASL10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide ISS --
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RASL10B: view

No data available for Pathways by source for RASL10B Gene

Transcripts for RASL10B Gene

mRNA/cDNA for RASL10B Gene

(60) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASL10B Gene

RAS-like, family 10, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASL10B Gene

No ASD Table

Relevant External Links for RASL10B Gene

GeneLoc Exon Structure for
RASL10B
ECgene alternative splicing isoforms for
RASL10B

Expression for RASL10B Gene

mRNA expression in normal human tissues for RASL10B Gene

mRNA differential expression in normal tissues according to GTEx for RASL10B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (4.1) and Brain - Nucleus accumbens (basal ganglia) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RASL10B Gene

SOURCE GeneReport for Unigene cluster for RASL10B Gene Hs.744994

mRNA Expression by UniProt/SwissProt for RASL10B Gene

Q96S79-RSLAB_HUMAN
Tissue specificity: Expressed at high levels in skeletal muscle and, at much lower levels, in heart, brain and pancreas.
genes like me logo Genes that share expressions with RASL10B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RASL10B Gene

Orthologs for RASL10B Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASL10B 35
  • 99.51 (n)
  • 99.51 (a)
cow
(Bos Taurus)
Mammalia RASL10B 35
  • 96.39 (n)
  • 99.51 (a)
dog
(Canis familiaris)
Mammalia RASL10B 35
  • 95.73 (n)
  • 98.52 (a)
mouse
(Mus musculus)
Mammalia Rasl10b 35
  • 93.76 (n)
  • 99.01 (a)
Rasl10b 16
rat
(Rattus norvegicus)
Mammalia LOC100912246 35
  • 94.25 (n)
  • 99.51 (a)
chicken
(Gallus gallus)
Aves RASL10B 35
  • 85.39 (n)
  • 91.63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl10b 35
  • 77.18 (n)
  • 87.68 (a)
zebrafish
(Danio rerio)
Actinopterygii rasl10a 35
  • 63.88 (n)
  • 61.08 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002563 35
  • 50.17 (n)
  • 39.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14669 35
  • 52.5 (n)
  • 42.51 (a)
Species with no ortholog for RASL10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASL10B Gene

ENSEMBL:
Gene Tree for RASL10B (if available)
TreeFam:
Gene Tree for RASL10B (if available)

Paralogs for RASL10B Gene

Selected SIMAP similar genes for RASL10B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASL10B: view

No data available for Paralogs for RASL10B Gene

Variants for RASL10B Gene

Sequence variations from dbSNP and Humsavar for RASL10B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs178940 -- 35,735,667(-) CCATA(A/T)ATTTT intron-variant
rs226417 -- 35,743,264(-) CCCCC(C/T)CACCC utr-variant-3-prime
rs226418 -- 35,742,974(-) GCTAC(C/G)CCCCA utr-variant-3-prime
rs226419 -- 35,739,538(+) TTGAG(A/T)AGTTG intron-variant
rs226420 -- 35,738,374(-) GATTC(C/T)TAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASL10B Gene

Variant ID Type Subtype PubMed ID
nsv908080 CNV Loss 21882294

Relevant External Links for RASL10B Gene

HapMap Linkage Disequilibrium report
RASL10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASL10B Gene

Disorders for RASL10B Gene

Relevant External Links for RASL10B

Genetic Association Database (GAD)
RASL10B
genes like me logo Genes that share disorders with RASL10B: view

No data available for UniProtKB/Swiss-Prot for RASL10B Gene

Publications for RASL10B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Regulation of atrial natriuretic peptide secretion by a novel Ras- like protein. (PMID: 17984325) Rybkin I.I. … Olson E.N. (J. Cell Biol. 2007) 3 4
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for RASL10B Gene

Sources for RASL10B Gene

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