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Aliases for RASL10A Gene

Aliases for RASL10A Gene

  • RAS-Like, Family 10, Member A 2 3
  • RRP22 3 4 6
  • Ras-Related Protein On Chromosome 22 3 4
  • Ras-Like Protein RRP22 3 4
  • Ras-Like Protein Family Member 10A 3

External Ids for RASL10A Gene

Previous GeneCards Identifiers for RASL10A Gene

  • GC22M028038
  • GC22M029708
  • GC22M012673

Summaries for RASL10A Gene

GeneCards Summary for RASL10A Gene

RASL10A (RAS-Like, Family 10, Member A) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for RASL10A Gene

  • Potent inhibitor of cellular proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL10A Gene

Genomics for RASL10A Gene

Regulatory Elements for RASL10A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASL10A Gene

29,312,933 bp from pter
29,319,679 bp from pter
6,747 bases
Minus strand

Genomic View for RASL10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASL10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL10A Gene

Proteins for RASL10A Gene

  • Protein details for RASL10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-like protein family member 10A
    Protein Accession:
    Secondary Accessions:
    • Q49AU5
    • Q6PI03

    Protein attributes for RASL10A Gene

    203 amino acids
    Molecular mass:
    22541 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RASL10A Gene


neXtProt entry for RASL10A Gene

Proteomics data for RASL10A Gene at MOPED

Post-translational modifications for RASL10A Gene

  • Isoprenylation is essential for nucleolar localization, and the proliferation-inhibiting activity of RASL10A.

Other Protein References for RASL10A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RASL10A Gene

Domains for RASL10A Gene

Protein Domains for RASL10A Gene

Suggested Antigen Peptide Sequences for RASL10A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q92737
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL10A: view

No data available for Gene Families for RASL10A Gene

Function for RASL10A Gene

Molecular function for RASL10A Gene

UniProtKB/Swiss-Prot Function:
Potent inhibitor of cellular proliferation.

Gene Ontology (GO) - Molecular Function for RASL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 8975699
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL10A: view

Animal Model Products

CRISPR Products

miRNA for RASL10A Gene

miRTarBase miRNAs that target RASL10A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASL10A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RASL10A Gene

Localization for RASL10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASL10A Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Nucleus, nucleolus. Note=May cycle in and out of the nucleolus in a GTP-dependent manner.

Subcellular locations from

Jensen Localization Image for RASL10A Gene COMPARTMENTS Subcellular localization image for RASL10A gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RASL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RASL10A: view

Pathways for RASL10A Gene

SuperPathways for RASL10A Gene

No Data Available

Interacting Proteins for RASL10A Gene

Gene Ontology (GO) - Biological Process for RASL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008152 metabolic process TAS 8975699
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RASL10A: view

No data available for Pathways by source for RASL10A Gene

Transcripts for RASL10A Gene

Unigene Clusters for RASL10A Gene

RAS-like, family 10, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASL10A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASL10A Gene

ExUns: 1a · 1b ^ 2 ^ 3

Relevant External Links for RASL10A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASL10A Gene

mRNA expression in normal human tissues for RASL10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASL10A Gene

This gene is overexpressed in Brain - Amygdala (6.9), Brain - Cortex (5.9), Brain - Anterior cingulate cortex (BA24) (5.5), Brain - Hippocampus (5.0), and Brain - Frontal Cortex (BA9) (4.8).

SOURCE GeneReport for Unigene cluster for RASL10A Gene Hs.73088

mRNA Expression by UniProt/SwissProt for RASL10A Gene

Tissue specificity: Expression appears to be strictly limited to the central nervous system.
genes like me logo Genes that share expressions with RASL10A: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for RASL10A Gene

Orthologs for RASL10A Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL10A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASL10A 35
  • 92.45 (n)
  • 98.03 (a)
RASL10A 36
  • 98 (a)
(Canis familiaris)
Mammalia RASL10A 35
  • 93.1 (n)
  • 96.55 (a)
RASL10A 36
  • 97 (a)
(Mus musculus)
Mammalia Rasl10a 35
  • 86.7 (n)
  • 95.07 (a)
Rasl10a 16
Rasl10a 36
  • 95 (a)
(Pan troglodytes)
Mammalia RASL10A 35
  • 100 (n)
  • 100 (a)
RASL10A 36
  • 100 (a)
(Monodelphis domestica)
Mammalia RASL10A 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia RASL10A 36
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl10a 35
  • 56.18 (n)
  • 51.27 (a)
(Danio rerio)
Actinopterygii rasl10a 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14669 36
  • 22 (a)
Species with no ortholog for RASL10A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASL10A Gene

Gene Tree for RASL10A (if available)
Gene Tree for RASL10A (if available)

Paralogs for RASL10A Gene

Paralogs for RASL10A Gene

Selected SIMAP similar genes for RASL10A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASL10A: view

Variants for RASL10A Gene

Sequence variations from dbSNP and Humsavar for RASL10A Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs174762 -- 29,314,336(+) CCGAG(C/T)CCCGT intron-variant
rs174763 -- 29,317,056(+) ATGCT(A/G)GATCG upstream-variant-2KB
rs450612 -- 29,316,727(+) ATGGC(C/G)GCAAT upstream-variant-2KB
rs695646 -- 29,313,674(+) CACCG(-/C)CCCCC intron-variant
rs1858804 -- 29,317,061(+) AGATC(A/G)GGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RASL10A Gene

Variant ID Type Subtype PubMed ID
nsv829154 CNV Gain 20364138
nsv834171 CNV Loss 17160897
nsv829155 CNV Loss 20364138
dgv4951n71 CNV Loss 21882294

Relevant External Links for RASL10A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASL10A Gene

Disorders for RASL10A Gene

No disorders were found for RASL10A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RASL10A Gene

Publications for RASL10A Gene

  1. RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential. (PMID: 15833841) Elam C. … Clark G.J. (Cancer Res. 2005) 3 4 23
  2. Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. (PMID: 8975699) Zucman-Rossi J. … Thomas G. (Genomics 1996) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The Ras superfamily at a glance. (PMID: 15731001) Wennerberg K. … Der C.J. (J. Cell. Sci. 2005) 2 3
  5. Regulation of atrial natriuretic peptide secretion by a novel Ras- like protein. (PMID: 17984325) Rybkin I.I. … Olson E.N. (J. Cell Biol. 2007) 3

Products for RASL10A Gene

Sources for RASL10A Gene

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