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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASL10A Gene

protein-coding   GIFtS: 44
GCID: GC22M029708

RAS-like, family 10, member A
  Search for RASL10A
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 Human Malady Compendium 
Biological research products
for RASL10A    

Aliases
for RASL10A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAS-Like, Family 10, Member A1 2
RRP221 2 3 5
Ras-Like Protein RRP222 3
Ras-Related Protein On Chromosome 222 3
Ras-Like Protein Family Member 10A2

External Ids:    HGNC: 169541   Entrez Gene: 106332   Ensembl: ENSG000001002767   OMIM: 6022205   UniProtKB: Q927373   

Export aliases for RASL10A gene to outside databases

Previous GC identifers: GC22M028038 GC22M012673


Summaries
for RASL10A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RSLAA_HUMAN, Q92737
Function: Potent inhibitor of cellular proliferation




Genomic Views
for RASL10A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASL10A gene promoter:
         GR   MAZR   Pax-5   Pax-2   Pax-2a   PPAR-alpha   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RASL10A promoter sequence
   Search SABiosciences Chromatin IP Primers for RASL10A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASL10A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

RASL10A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASL10A gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M029708:  view genomic region     (about GC identifiers)

Start:
 29,708,922 bp from pter      End:
 29,711,748 bp from pter
Size:
 2,827 bases      Orientation:
 minus strand

Proteins
for RASL10A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RSLAA_HUMAN, Q92737 (See protein sequence)
Recommended Name: Ras-like protein family member 10A precursor  
Size: 203 amino acids; 22541 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Nucleus, nucleolus. Note=May cycle in
and out of the nucleolus in a GTP-dependent manner
Secondary accessions: Q49AU5 Q6PI03
Alternative splicing: 2 isoforms:  Q92737-1   Q92737-2   

Explore the universe of human proteins at neXtProt for RASL10A: NX_Q92737

Post-translational modifications:

  • Isoprenylation is essential for nucleolar localization, and the proliferation-inhibiting activity of RASL10A1
  • View neXtProt modification sites for NX_Q92737

    • RASL10A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006468.1  
    ENSEMBL proteins: 
     ENSP00000386095   ENSP00000216101  

    Human Recombinant Protein Products: 
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    Novus Biologicals RASL10A Protein
    Novus Biologicals RASL10A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RASL10A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005886plasma membrane IEA--


    RASL10A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RASL10A

    Protein Domains /
    Families
    for RASL10A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RASL10A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001806 Small_GTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q92737

    ProtoNet protein and cluster: Q92737

    2 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB013684 Miro-like


    UniProtKB/Swiss-Prot: RSLAA_HUMAN, Q92737
    Similarity: Belongs to the small GTPase superfamily. Ras family


    Function
    for RASL10A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RSLAA_HUMAN, Q92737
    Function: Potent inhibitor of cellular proliferation

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: RASL10A
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for RASL10A

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--


    RASL10A for ontologies           About GeneDecksing



    Pathways & Interactions
    for RASL10A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASL10A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for RASL10A (ENSP000002161014) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATMENSP000002786164STRING: ENSP00000278616
    ATRENSP000003437414STRING: ENSP00000343741
    MTORENSP000003545584STRING: ENSP00000354558
    RAF1ENSP000002518494STRING: ENSP00000251849
    RPTORENSP000003072724STRING: ENSP00000307272
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007264small GTPase mediated signal transduction IEA--


    RASL10A for ontologies           About GeneDecksing



    Drugs & Compounds
    for RASL10A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RASL10A
    Search CenterWatch for drugs/clinical trials and news about RASL10A / RSLAA 

    Transcripts
    for RASL10A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RASL10A gene (2 alternative transcripts): 
    NM_001007279.1  NM_006477.4  

    Unigene Cluster for RASL10A:

    RAS-like, family 10, member A
    Hs.73088  [show with all ESTs]
    Unigene Representative Sequence: BC022473
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401450(uc003afg.3) ENST00000216101(uc003aff.3) ENST00000474590


    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RASL10A (see all 7)
    OriGene shRNA RFP: RASL10A
    OriGene siRNA: RASL10A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASL10A
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): RASL10A (NM_006477)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASL10A 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASL10A

    Additional cDNA sequence: 

    BC022473.1 BC058077.1 Y07847.1 

    5 DOTS entries:

    DT.101979834  DT.102821329  DT.95266064  DT.91754088  DT.99955837 

    24/28 AceView cDNA sequences (see all 28):

    BX111994 NM_006477 Y07847 BC040434 BC058077 CR615340 BC050739 BI918421 
    BG819780 BQ647202 BC022473 BG706751 AI569698 BX400491 AI656831 AW137223 
    BF436320 BI918646 AA476344 AI968999 BG706474 AI825736 AW138462 AI880043 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RASL10A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for RASL10A

    Expression
    for RASL10A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASL10A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCCCCACCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RASL10A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BoneZeugopod Epiphyseal EndBone
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)

    See RASL10A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASL10A

    SOURCE GeneReport for Unigene cluster: Hs.73088

    UniProtKB/Swiss-Prot: RSLAA_HUMAN, Q92737
    Tissue specificity: Expression appears to be strictly limited to the central nervous system

        SABiosciences Custom PCR Arrays for RASL10A
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASL10A

    Orthologs
    for RASL10A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RASL10A gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rasl10a1 , 5 RAS-like, family 10, member A1, 5 86.7(n)1
    95.07(a)1    		   11 (3.21 cM)5
    756681  NM_145216.31  NP_660251.11 
     50581285 
    zebrafish
    (Danio rerio)    		 Actinopterygii rasl10a6
    		 RAS-like, family 10, member A
    		 51(a)
    		 1 → many
    		 5(26392340-26419221)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG146696
    		 --
    		 21(a)
    		 1 → many
    		 3R(1240275-1283322)


    ENSEMBL Gene Tree for RASL10A (if available)
    TreeFam Gene Tree for RASL10A (if available) 

    Paralogs
    for RASL10A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASL10A gene
    RAP2C2  RASL10B2  DIRAS12  RAP1B2  RASD22  RAP2A2  RAP1A2  RAP2B2  
    RASD12  DIRAS22  DIRAS32  
    6 SIMAP similar genes for RASL10A using alignment to 2 protein entries:     RSLAA_HUMAN (see all proteins):
    RASL10B    DIRAS1    RAP2B    DIRAS2    RAP2A    RAP1A

    RASL10A for paralogs           About GeneDecksing



    Genomic Variants
    for RASL10A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/93 NCBI SNPs in RASL10A are shown (see all 93)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs412816151,2
    		--12672738(+) CAGCTC/TAGCTG 3 -- ut310--------
    rs770924991,2
    		C,F,--12673025(+) TGTCTG/ATTTCT 3 -- ds50011Minor allele frequency- A:0.09WA 118
    rs793932361,2
    		--12673038(+) GGGACC/TCCACC 3 -- ds50010--------
    rs60060921,2
    		C,F,A,H,--12673057(+) ATTCAG/AACCCT 3 -- ds50016Minor allele frequency- A:0.06NS NA WA 910
    rs797056841,2
    		C,F,--12673299(+) ACCCAT/CTGAGG 3 -- ds50011Minor allele frequency- C:0.09WA 118
    rs1169364881,2
    		--29708524(+) CTTCTC/TCTTTT 4 -- ut31 int11Minor allele frequency- T:0.01EA 120
    rs32168031,2
    		C,--29708797(+) GGGACT/-CCACC 4 -- ds5001 int11Minor allele frequency- -:0.50CSA 2
    rs1446347031,2
    		--29708893(+) GTTATA/CCCGCC 4 -- int1 ds50010--------
    rs1886060621,2
    		--29708940(+) CCTTTC/TATTAT 4 -- ut31 ds50010--------
    rs1474504861,2
    		--29708951(+) CCCGTG/TGTAGG 4 -- ut31 ds50010--------

    HapMap Linkage Disequilibrium report for RASL10A (29708922 - 29711748 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RASL10A: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RASL10A
    DNA2.0 Custom Variant and Variant Library Synthesis for RASL10A

    Disorders / Diseases
    for RASL10A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RASL10A for disorders           About MalaCards

    RASL10A for disorders           About GeneDecksing

    OMIM gene information: 602220    OMIM disorders: --


    Export disorders for RASL10A gene to outside databases

    Publications
    for RASL10A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASL10A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RASL10A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. (PubMed id 8975699)1, 2, 3 Zucman-Rossi J.... Thomas G. (1996)
    2. RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential. (PubMed id 15833841)1, 2, 9 Elam C....Clark G.J. (2005)
    3. The Ras superfamily at a glance. (PubMed id 15731001)1, 3 Wennerberg K....Der C.J. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. RRP22: a novel neural tumor suppressor for astrocytoma . (PubMed id 21264544)1 Chen R....Wang Y. (2012)
    6. DNA hypermethylation and histone modifications downreg ulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas. (PubMed id 21631628)1 Schmidt N....Riemenschneider M.J. (2012)
    7. 22q11.2 deletion syndrome: are motor deficits more th an expected for IQ level? (PubMed id 20646714)1 Roizen N.J....Kates W.R. (2010)
    8. Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. (PubMed id 17984325)1 Rybkin I.I....Olson E.N. (2007)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)

    External Searches for RASL10A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    NCBI Bookshelf
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    Genome Databases showing RASL10A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10633 HGNC: 16954 AceView: RRP22 Ensembl:ENSG00000100276 euGenes: HUgn10633
    ECgene: RASL10A H-InvDB: RASL10A

    Other Databases showing RASL10A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RASL10A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASL10A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RASL10A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RASL10A gene:
    Search GeneIP for patents involving RASL10A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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