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RASL10A Gene

protein-coding   GIFtS: 46
GCID: GC22M029708

RAS-Like, Family 10, Member A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAS-Like, Family 10, Member A1 2
RRP222 3 5
Ras-Like Protein RRP222 3
Ras-Related Protein On Chromosome 222 3
Ras-Like Protein Family Member 10A2

External Ids:    HGNC: 169541   Entrez Gene: 106332   Ensembl: ENSG000001002767   OMIM: 6022205   UniProtKB: Q927373   

Export aliases for RASL10A gene to outside databases

Previous GC identifers: GC22M028038 GC22M012673


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RASL10A Gene:
RASL10A (RAS-like, family 10, member A) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RSLAA_HUMAN, Q92737
Function: Potent inhibitor of cellular proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASL10A gene promoter:
         GR   MAZR   Pax-5   Pax-2   Pax-2a   PPAR-alpha   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASL10A promoter sequence
   Search Chromatin IP Primers for RASL10A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASL10A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

RASL10A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASL10A gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M029708:  view genomic region     (about GC identifiers)

Start:
29,708,922 bp from pter      End:
29,715,668 bp from pter
Size:
6,747 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RSLAA_HUMAN, Q92737 (See protein sequence)
Recommended Name: Ras-like protein family member 10A precursor  
Size: 203 amino acids; 22541 Da
Secondary accessions: Q49AU5 Q6PI03
Alternative splicing: 2 isoforms:  Q92737-1   Q92737-2   

Explore the universe of human proteins at neXtProt for RASL10A: NX_Q92737

Explore proteomics data for RASL10A at MOPED

Post-translational modifications: 

  • Isoprenylation is essential for nucleolar localization, and the proliferation-inhibiting activity of RASL10A1
  • Modification sites at neXtProt

  • See RASL10A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006468.1  
    ENSEMBL proteins: 
     ENSP00000386095   ENSP00000216101  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q92737

    ProtoNet protein and cluster: Q92737

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB013684 Miro-like


    UniProtKB/Swiss-Prot: RSLAA_HUMAN, Q92737
    Similarity: Belongs to the small GTPase superfamily. Ras family


    Find genes that share domains with RASL10A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSLAA_HUMAN, Q92737
    Function: Potent inhibitor of cellular proliferation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS8975699
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RASL10A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASL10A
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    miRNA
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    miRTarBase miRNAs that target RASL10A:
    hsa-mir-335-5p (MIRT016791)

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    SwitchGear 3'UTR luciferase reporter plasmidRASL10A 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RSLAA_HUMAN, Q92737: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Nucleus, nucleolus. Note=May
    cycle in and out of the nucleolus in a GTP-dependent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005730nucleolus IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with RASL10A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASL10A
    Interactions:

        Search GeneGlobe Interaction Network for RASL10A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for RASL10A (ENSP000002161014) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATMENSP000002786164STRING: ENSP00000278616
    ATRENSP000003437414STRING: ENSP00000343741
    MTORENSP000003545584STRING: ENSP00000354558
    RAF1ENSP000002518494STRING: ENSP00000251849
    RPTORENSP000003072724STRING: ENSP00000307272
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    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    Find genes that share ontologies with RASL10A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASL10A (RSLAA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RASL10A gene (2 alternative transcripts): 
    NM_001007279.1  NM_006477.4  

    Unigene Cluster for RASL10A:

    RAS-like, family 10, member A
    Hs.73088  [show with all ESTs]
    Unigene Representative Sequence: BC022473
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401450(uc003afg.3) ENST00000216101(uc003aff.3) ENST00000608559
    ENST00000474590
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RASL10A
      QuantiFast Probe-based Assays in human, mouse, rat RASL10A

    Additional mRNA sequence: 

    BC022473.1 BC058077.1 Y07847.1 

    5 DOTS entries:

    DT.101979834  DT.102821329  DT.95266064  DT.91754088  DT.99955837 

    Selected AceView cDNA sequences (see all 28):

    Y07847 CR615340 BC050739 NM_006477 BC040434 BC058077 BX111994 BI918421 
    BC022473 BF436320 AW137223 BQ647202 AI656831 AI569698 BG706751 BX400491 
    BG819780 BI918646 AA476344 BG706474 AI825736 AW138462 AI968999 AI880043 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RASL10A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for RASL10A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASL10A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCCACCT
    RASL10A Expression
    About this image


    RASL10A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Epiphyseal End
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Kidney (Urinary System)
             Ureteric Bud
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
    RASL10A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASL10A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73088

    UniProtKB/Swiss-Prot: RSLAA_HUMAN, Q92737
    Tissue specificity: Expression appears to be strictly limited to the central nervous system

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASL10A gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasl10a1 , 5 RAS-like, family 10, member A1, 5 86.7(n)1
    95.07(a)1
      11 (3.21 cM)5
    756681  NM_145216.31  NP_660251.11 
     50581285 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Small GTPase Ras-dva; Uncharacterized protein
    31(a)
    many ↔ many
    2(110918759-110919385)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rasl10a1 RAS-like, family 10, member A 56.18(n)
    51.27(a)
      448561  NM_001005037.1  NP_001005037.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rasl10a6
    RAS-like, family 10, member A
    53(a)
    1 ↔ 1
    5(26392340-26419221) ENSDARG00000062314
    fruit fly
    (Drosophila melanogaster)
    Insecta CG146696
    --
    22(a)
    1 → many
    3R(1240275-1283322)


    ENSEMBL Gene Tree for RASL10A (if available)
    TreeFam Gene Tree for RASL10A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASL10A gene
    RAP2C2  RASL10B2  DIRAS12  RAP1B2  RASD22  RIT22  RAP2A2  RIT12  
    RAP1A2  RAP2B2  RASD12  DIRAS22  DIRAS32  
    5 SIMAP similar genes for RASL10A using alignment to 2 protein entries:     RSLAA_HUMAN (see all proteins):
    RASL10B    DIRAS1    RAP2B    DIRAS2    RAP2A

    Find genes that share paralogs with RASL10A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASL10A (see all 94)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs744363931,2
    --29709340(+) CAGGGC/GCGGGT 2 P A mis10--------
    rs81427251,2
    C,A,H--29709359(+) CGCGCG/ACGCAC 2 /R syn12Minor allele frequency- A:0.23NA WA 120
    rs1995538741,2
    --29709601(+) CGGCCA/GGAGAA 1 -- int10--------
    rs6956461,2
    C--29709663(+) CACCG-/CCCCCC 1 -- int10--------
    rs1170244291,2
    F--29709670(+) CCCCCC/GCGCCG 1 -- int11Minor allele frequency- G:0.04NA 120
    rs1161267071,2
    C,F--29709778(+) GACCCT/CACACA 1 -- int11Minor allele frequency- C:0.09WA 118
    rs2018275771,2
    C--29709804(+) GGCCCA/TGCCAG 1 -- int10--------
    rs1172488341,2
    C--29709844(+) GCCGGG/ACCCCT 1 -- int11Minor allele frequency- A:0.01EA 120
    rs1508910691,2
    F--29709886(+) CTTCAC/AGTAGT 2 /V /L mis11Minor allele frequency- A:0.00NA 4540
    rs1486919121,2
    C--29709989(+) CAGGAG/AGCCAG 1 -- int11Minor allele frequency- A:0.00EU 1295

    HapMap Linkage Disequilibrium report for RASL10A (29708922 - 29715668 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RASL10A:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4951n71CNV Loss21882294
    nsv829155CNV Loss20364138
    nsv834171CNV Loss17160897
    nsv829154CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602220    OMIM disorders: --


    Find genes that share disorders with RASL10A           About GenesLikeMe


    Export disorders for RASL10A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASL10A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with RASL10A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. (PubMed id 8975699)1, 2, 3 Zucman-Rossi J.... Thomas G. (Genomics 1996)
    2. RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential. (PubMed id 15833841)1, 2, 9 Elam C.... Clark G.J. (Cancer Res. 2005)
    3. The Ras superfamily at a glance. (PubMed id 15731001)1, 3 Wennerberg K....Der C.J. (J. Cell. Sci. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. RRP22: a novel neural tumor suppressor for astrocytoma. (PubMed id 21264544)1 Chen R....Wang Y. (Med. Oncol. 2012)
    6. DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas. (PubMed id 21631628)1 Schmidt N....Riemenschneider M.J. (Brain Pathol. 2012)
    7. 22q11.2 deletion syndrome: are motor deficits more than expected for IQ level? (PubMed id 20646714)1 Roizen N.J....Kates W.R. (J. Pediatr. 2010)
    8. Regulation of atrial natriuretic peptide secretion by a novel Ras- like protein. (PubMed id 17984325)1 Rybkin I.I.... Olson E.N. (J. Cell Biol. 2007)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I.... Wright H. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10633 HGNC: 16954 AceView: RRP22 Ensembl:ENSG00000100276 euGenes: HUgn10633
    ECgene: RASL10A H-InvDB: RASL10A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RASL10A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RASL10A gene:
    Search GeneIP for patents involving RASL10A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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