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Aliases for RASIP1 Gene

Aliases for RASIP1 Gene

  • Ras Interacting Protein 1 2 3 5
  • RAIN 3 4
  • Ras-Interacting Protein 1 3

External Ids for RASIP1 Gene

Previous GeneCards Identifiers for RASIP1 Gene

  • GC19M053916
  • GC19M053917
  • GC19M049223
  • GC19M045604

Summaries for RASIP1 Gene

GeneCards Summary for RASIP1 Gene

RASIP1 (Ras Interacting Protein 1) is a Protein Coding gene. An important paralog of this gene is RADIL.

UniProtKB/Swiss-Prot for RASIP1 Gene

  • Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASIP1 Gene

Genomics for RASIP1 Gene

Regulatory Elements for RASIP1 Gene

Enhancers for RASIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F048672 1.2 Ensembl ENCODE 16.7 +64.9 64873 7.0 ARID4B YBX1 ZNF48 YY1 ZNF121 ZNF143 ZNF207 KLF13 ZNF263 YY2 FUT2 RASIP1 MAMSTR DBP SEC1P IZUMO1 BCAT2 NUCB1 TULP2 NUCB1-AS1
GH19F048712 1.1 ENCODE 17.6 +23.5 23521 8.6 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FUT2 IZUMO1 TEAD2 RASIP1 PLEKHA4 KDELR1 ENSG00000268157 ENSG00000197813 RRAS GRWD1
GH19F048958 1.7 FANTOM5 ENCODE 10.7 -223.2 -223217 10.2 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ENSG00000269321 NUP62 PRR12 TEAD2 PPP1R15A RUVBL2 KDELR1 PIH1D1 GRWD1 ENSG00000268157
GH19F048794 1.4 Ensembl ENCODE 11.5 -55.0 -55021 2.7 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 TEAD2 KDELR1 PRR12 GRWD1 ENSG00000197813 SNORD35A NUCB1-AS1 PLEKHA4 ALDH16A1 ENSG00000268157
GH19F048328 1.4 FANTOM5 ENCODE 10.9 +409.1 409148 5.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 GRWD1 KDELR1 GLTSCR2-AS1 TMEM143 EHD2 GLTSCR1 PLEKHA4 SYNGR4 EMP3 RASIP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASIP1 on UCSC Golden Path with GeneCards custom track

Promoters for RASIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001419753 1113 2601 HDGF ATF1 PKNOX1 CREB3L1 SIN3A ZNF48 GLIS2 SP3 REST SMARCA4

Genomic Location for RASIP1 Gene

Chromosome:
19
Start:
48,720,585 bp from pter
End:
48,740,813 bp from pter
Size:
20,229 bases
Orientation:
Minus strand

Genomic View for RASIP1 Gene

Genes around RASIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASIP1 Gene

Proteins for RASIP1 Gene

  • Protein details for RASIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U651-RAIN_HUMAN
    Recommended name:
    Ras-interacting protein 1
    Protein Accession:
    Q5U651
    Secondary Accessions:
    • Q6U676

    Protein attributes for RASIP1 Gene

    Size:
    963 amino acids
    Molecular mass:
    103457 Da
    Quaternary structure:
    • Interacts with Ras family members that have been activated by GTP binding. Interacts with HRAS, RAP1A, RAP2, RRAS, RAF1 and RRAS2. Interacts with MYH9 and ARHGAP29 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RASIP1 Gene

neXtProt entry for RASIP1 Gene

Post-translational modifications for RASIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASIP1 Gene

No data available for DME Specific Peptides for RASIP1 Gene

Domains & Families for RASIP1 Gene

Protein Domains for RASIP1 Gene

Suggested Antigen Peptide Sequences for RASIP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5U651

UniProtKB/Swiss-Prot:

RAIN_HUMAN :
  • Contains 1 dilute domain.
Domain:
  • Contains 1 dilute domain.
  • Contains 1 Ras-associating domain.
genes like me logo Genes that share domains with RASIP1: view

No data available for Gene Families for RASIP1 Gene

Function for RASIP1 Gene

Molecular function for RASIP1 Gene

UniProtKB/Swiss-Prot Function:
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
genes like me logo Genes that share phenotypes with RASIP1: view

Animal Models for RASIP1 Gene

MGI Knock Outs for RASIP1:

Animal Model Products

miRNA for RASIP1 Gene

miRTarBase miRNAs that target RASIP1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASIP1 Gene

Localization for RASIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASIP1 Gene

Cytoplasm, perinuclear region. Golgi apparatus, Golgi stack. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASIP1 gene
Compartment Confidence
nucleus 3
golgi apparatus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RASIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with RASIP1: view

Pathways & Interactions for RASIP1 Gene

SuperPathways for RASIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0001570 vasculogenesis IEA,ISS --
GO:0007165 signal transduction IEA --
GO:0010507 negative regulation of autophagy IMP 22354037
GO:0043087 regulation of GTPase activity IEA,ISS --
genes like me logo Genes that share ontologies with RASIP1: view

No data available for Pathways by source and SIGNOR curated interactions for RASIP1 Gene

Drugs & Compounds for RASIP1 Gene

(1) Drugs for RASIP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RASIP1: view

Transcripts for RASIP1 Gene

Unigene Clusters for RASIP1 Gene

Ras interacting protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASIP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2:
SP3: -
SP4: - - - - - -
SP5:

Relevant External Links for RASIP1 Gene

GeneLoc Exon Structure for
RASIP1
ECgene alternative splicing isoforms for
RASIP1

Expression for RASIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASIP1 Gene

Protein differential expression in normal tissues from HIPED for RASIP1 Gene

This gene is overexpressed in Lung (12.4), Brain (8.8), Heart (6.7), Placenta (6.4), and Platelet (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASIP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of RASIP1 Gene:

RASIP1

SOURCE GeneReport for Unigene cluster for RASIP1 Gene:

Hs.233955

mRNA Expression by UniProt/SwissProt for RASIP1 Gene:

Q5U651-RAIN_HUMAN
Tissue specificity: Highly expressed in heart. Detected at lower levels in placenta and pancreas.
genes like me logo Genes that share expression patterns with RASIP1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for RASIP1 Gene

Orthologs for RASIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASIP1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASIP1 34 35
  • 91.35 (n)
cow
(Bos Taurus)
Mammalia RASIP1 34 35
  • 90.69 (n)
rat
(Rattus norvegicus)
Mammalia Rasip1 34
  • 86.61 (n)
mouse
(Mus musculus)
Mammalia Rasip1 34 16 35
  • 85.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RASIP1 35
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASIP1 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASIP1 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasip1 34
  • 58.65 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100151130 34
  • 52.7 (n)
rasip1 35
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToMany
Species where no ortholog for RASIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASIP1 Gene

ENSEMBL:
Gene Tree for RASIP1 (if available)
TreeFam:
Gene Tree for RASIP1 (if available)

Paralogs for RASIP1 Gene

Paralogs for RASIP1 Gene

(1) SIMAP similar genes for RASIP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RASIP1: view

Variants for RASIP1 Gene

Sequence variations from dbSNP and Humsavar for RASIP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401740 -- 48,736,575(+) TGGGT(A/G)CTCTG intron-variant
rs10412946 -- 48,727,694(+) ttttt(G/T)ttttt intron-variant
rs111269191 -- 48,724,978(+) AGAAG(C/T)GGAAA intron-variant
rs111892853 -- 48,726,483(+) GACCT(C/T)CCAAA intron-variant
rs112994930 -- 48,723,822(+) TTTTT(C/T)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASIP1 Gene

Variant ID Type Subtype PubMed ID
nsv1144878 CNV deletion 24896259
nsv471822 CNV novel sequence insertion 20440878
nsv9739 CNV gain+loss 18304495

Variation tolerance for RASIP1 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.38; 81.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASIP1 Gene

Disorders for RASIP1 Gene

Relevant External Links for RASIP1

Genetic Association Database (GAD)
RASIP1
Human Genome Epidemiology (HuGE) Navigator
RASIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASIP1

No disorders were found for RASIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASIP1 Gene

Publications for RASIP1 Gene

  1. Identification and characterization of Rain, a novel Ras-interacting protein with a unique subcellular localization. (PMID: 15031288) Mitin N.Y. … Taparowsky E.J. (J. Biol. Chem. 2004) 2 3 4 22 64
  2. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight N.C. … Tooze S.A. (EMBO J. 2012) 3 4 64
  3. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. (PMID: 21060863) Ikram M.K. … Wong T.Y. (PLoS Genet. 2010) 3 46 64

Products for RASIP1 Gene

Sources for RASIP1 Gene

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