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Aliases for RASIP1 Gene

Aliases for RASIP1 Gene

  • Ras Interacting Protein 1 2 3
  • RAIN 3 4 6
  • Ras-Interacting Protein 1 3

External Ids for RASIP1 Gene

Summaries for RASIP1 Gene

GeneCards Summary for RASIP1 Gene

RASIP1 (Ras Interacting Protein 1) is a Protein Coding gene. An important paralog of this gene is RADIL.

UniProtKB/Swiss-Prot for RASIP1 Gene

  • Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASIP1 Gene

Genomics for RASIP1 Gene

Genomic Location for RASIP1 Gene

Start:
48,720,585 bp from pter
End:
48,740,887 bp from pter
Size:
20,303 bases
Orientation:
Minus strand

Genomic View for RASIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASIP1 Gene

Regulatory Elements for RASIP1 Gene

Transcription factor binding sites by QIAGEN in the RASIP1 gene promoter:

Proteins for RASIP1 Gene

  • Protein details for RASIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U651-RAIN_HUMAN
    Recommended name:
    Ras-interacting protein 1
    Protein Accession:
    Q5U651
    Secondary Accessions:
    • Q6U676

    Protein attributes for RASIP1 Gene

    Size:
    963 amino acids
    Molecular mass:
    103457 Da
    Quaternary structure:
    • Interacts with Ras family members that have been activated by GTP binding. Interacts with HRAS, RAP1A, RAP2, RRAS, RAF1 and RRAS2. Interacts with MYH9 and ARHGAP29 (By similarity).

neXtProt entry for RASIP1 Gene

Proteomics data for RASIP1 Gene at MOPED

Post-translational modifications for RASIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASIP1 Gene

Domains for RASIP1 Gene

Protein Domains for RASIP1 Gene

Suggested Antigen Peptide Sequences for RASIP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5U651

UniProtKB/Swiss-Prot:

RAIN_HUMAN
Domain:
  • Contains 1 dilute domain.:
    • Q5U651
  • Contains 1 Ras-associating domain.:
    • Q5U651
genes like me logo Genes that share domains with RASIP1: view

No data available for Gene Families for RASIP1 Gene

Function for RASIP1 Gene

Molecular function for RASIP1 Gene

UniProtKB/Swiss-Prot Function: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.

Gene Ontology (GO) - Molecular Function for RASIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RASIP1: view
genes like me logo Genes that share phenotypes with RASIP1: view

Animal Models for RASIP1 Gene

MGI Knock Outs for RASIP1:

miRNA for RASIP1 Gene

miRTarBase miRNAs that target RASIP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RASIP1 Gene

Localization for RASIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASIP1 Gene

Cytoplasm, perinuclear region. Golgi apparatus, Golgi stack. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASIP1 Gene COMPARTMENTS Subcellular localization image for RASIP1 gene
Compartment Confidence
golgi apparatus 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RASIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus --
GO:0005795 Golgi stack IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with RASIP1: view

Pathways for RASIP1 Gene

SuperPathways for RASIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0001570 vasculogenesis ISS --
GO:0007165 signal transduction IEA --
GO:0010507 negative regulation of autophagy IMP 22354037
GO:0043087 regulation of GTPase activity ISS --
genes like me logo Genes that share ontologies with RASIP1: view

No data available for Pathways by source for RASIP1 Gene

Compounds for RASIP1 Gene

(1) HMDB Compounds for RASIP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RASIP1: view

Transcripts for RASIP1 Gene

Unigene Clusters for RASIP1 Gene

Ras interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASIP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2:
SP3: -
SP4: - - - - - -
SP5:

Relevant External Links for RASIP1 Gene

GeneLoc Exon Structure for
RASIP1
ECgene alternative splicing isoforms for
RASIP1

Expression for RASIP1 Gene

mRNA expression in normal human tissues for RASIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASIP1 Gene

SOURCE GeneReport for Unigene cluster for RASIP1 Gene Hs.233955

mRNA Expression by UniProt/SwissProt for RASIP1 Gene

Q5U651-RAIN_HUMAN
Tissue specificity: Highly expressed in heart. Detected at lower levels in placenta and pancreas.
genes like me logo Genes that share expressions with RASIP1: view

No data available for mRNA differential expression in normal tissues for RASIP1 Gene

Orthologs for RASIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASIP1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASIP1 35
  • 90.69 (n)
  • 97.3 (a)
RASIP1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASIP1 35
  • 91.35 (n)
  • 97.71 (a)
RASIP1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasip1 35
  • 85.41 (n)
  • 94.03 (a)
Rasip1 16
Rasip1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASIP1 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASIP1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasip1 35
  • 86.61 (n)
  • 96.59 (a)
lizard
(Anolis carolinensis)
Reptilia RASIP1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasip1 35
  • 58.65 (n)
  • 58.57 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100151130 35
  • 52.7 (n)
  • 47.71 (a)
rasip1 36
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for RASIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASIP1 Gene

ENSEMBL:
Gene Tree for RASIP1 (if available)
TreeFam:
Gene Tree for RASIP1 (if available)

Paralogs for RASIP1 Gene

Paralogs for RASIP1 Gene

Selected SIMAP similar genes for RASIP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RASIP1: view

Variants for RASIP1 Gene

Sequence variations from dbSNP and Humsavar for RASIP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs190734 -- 48,723,933(+) ctcca(A/G)agtaa intron-variant
rs281405 -- 48,724,253(+) AGCTC(C/T)GACGG intron-variant
rs281406 -- 48,727,955(+) AGTGC(C/T)GGGAT intron-variant
rs281407 -- 48,730,078(+) CACCC(A/G)CAACG intron-variant
rs281408 -- 48,730,149(+) GAAGA(A/C)CGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASIP1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3967n71 CNV Loss 21882294
nsv912236 CNV Gain 21882294
nsv912237 CNV Loss 21882294
nsv912238 CNV Gain 21882294
nsv912239 CNV Loss 21882294
dgv3968n71 CNV Loss 21882294
nsv912242 CNV Loss 21882294

Relevant External Links for RASIP1 Gene

HapMap Linkage Disequilibrium report
RASIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASIP1 Gene

Disorders for RASIP1 Gene

(1) University of Copenhagen DISEASES for RASIP1 Gene

Relevant External Links for RASIP1

Genetic Association Database (GAD)
RASIP1
Human Genome Epidemiology (HuGE) Navigator
RASIP1
genes like me logo Genes that share disorders with RASIP1: view

No data available for UniProtKB/Swiss-Prot for RASIP1 Gene

Publications for RASIP1 Gene

  1. Identification and characterization of Rain, a novel Ras-interacting protein with a unique subcellular localization. (PMID: 15031288) Mitin N.Y. … Taparowsky E.J. (J. Biol. Chem. 2004) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. (PMID: 21060863) Ikram M.K. … Wong T.Y. (PLoS Genet. 2010) 3 48
  5. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 48

Products for RASIP1 Gene

Sources for RASIP1 Gene

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