External Ids for RASGRP4 Gene
Previous GeneCards Identifiers for RASGRP4 Gene
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
GeneCards Summary for RASGRP4 Gene
RASGRP4 (RAS Guanyl Releasing Protein 4) is a Protein Coding gene. Diseases associated with RASGRP4 include Mast-Cell Leukemia and Mastocytosis. Among its related pathways are RET signaling and Immune System. GO annotations related to this gene include calcium ion binding and GTP-dependent protein binding. An important paralog of this gene is RASGRP1.
UniProtKB/Swiss-Prot for RASGRP4 Gene
Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.