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Aliases for RASGRP4 Gene

Aliases for RASGRP4 Gene

  • RAS Guanyl Releasing Protein 4 2 3

External Ids for RASGRP4 Gene

Previous GeneCards Identifiers for RASGRP4 Gene

  • GC19M039514
  • GC19M039291
  • GC19M043575
  • GC19M043591
  • GC19M038899
  • GC19M035347

Summaries for RASGRP4 Gene

Entrez Gene Summary for RASGRP4 Gene

  • The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for RASGRP4 Gene

RASGRP4 (RAS Guanyl Releasing Protein 4) is a Protein Coding gene. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include calcium ion binding and GTP-dependent protein binding. An important paralog of this gene is RASGRP3.

UniProtKB/Swiss-Prot for RASGRP4 Gene

  • Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRP4 Gene

Genomics for RASGRP4 Gene

Regulatory Elements for RASGRP4 Gene

Genomic Location for RASGRP4 Gene

38,409,051 bp from pter
38,426,305 bp from pter
17,255 bases
Minus strand

Genomic View for RASGRP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASGRP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRP4 Gene

Proteins for RASGRP4 Gene

  • Protein details for RASGRP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RAS guanyl-releasing protein 4
    Protein Accession:
    Secondary Accessions:
    • A6H8M4
    • C0LTP2
    • C0LTP3
    • C0LTP4
    • C0LTP5
    • C0LTP7
    • C9J416
    • C9JHZ1
    • Q8N858
    • Q96QN5
    • Q96QN6
    • Q96QN7

    Protein attributes for RASGRP4 Gene

    673 amino acids
    Molecular mass:
    74882 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RASGRP4 Gene

neXtProt entry for RASGRP4 Gene

Proteomics data for RASGRP4 Gene at MOPED

Post-translational modifications for RASGRP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RASGRP4 Gene

Domains for RASGRP4 Gene

Gene Families for RASGRP4 Gene

  • EFHAND :EF-hand domain containing

Graphical View of Domain Structure for InterPro Entry



  • Q8TDF6
  • The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG
  • Contains 1 EF-hand domain.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
  • Belongs to the RASGRP family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with RASGRP4: view

Function for RASGRP4 Gene

Molecular function for RASGRP4 Gene

UniProtKB/Swiss-Prot Function:
Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.

Gene Ontology (GO) - Molecular Function for RASGRP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity --
GO:0005088 Ras guanyl-nucleotide exchange factor activity IDA 11880369
GO:0005509 calcium ion binding IEA --
GO:0019992 diacylglycerol binding TAS 11880369
GO:0030742 GTP-dependent protein binding NAS 11880369
genes like me logo Genes that share ontologies with RASGRP4: view
genes like me logo Genes that share phenotypes with RASGRP4: view

Animal Models for RASGRP4 Gene

MGI Knock Outs for RASGRP4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASGRP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RASGRP4 Gene

Localization for RASGRP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASGRP4 Gene

Cytoplasm. Cell membrane. Note=Recruited to membranes upon activation by DAG.

Subcellular locations from

Jensen Localization Image for RASGRP4 Gene COMPARTMENTS Subcellular localization image for RASGRP4 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for RASGRP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS 11880369
GO:0016020 membrane IDA 11880369
genes like me logo Genes that share ontologies with RASGRP4: view

Pathways for RASGRP4 Gene

genes like me logo Genes that share pathways with RASGRP4: view

Pathways by source for RASGRP4 Gene

1 BioSystems pathway for RASGRP4 Gene
2 KEGG pathways for RASGRP4 Gene
1 GeneGo (Thomson Reuters) pathway for RASGRP4 Gene

Gene Ontology (GO) - Biological Process for RASGRP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS 11880369
GO:0007202 activation of phospholipase C activity NAS 11880369
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway NAS 11880369
GO:0008283 cell proliferation IDA 11880369
genes like me logo Genes that share ontologies with RASGRP4: view

Compounds for RASGRP4 Gene

(844) HMDB Compounds for RASGRP4 Gene

Compound Synonyms Cas Number PubMed IDs
  • DAG(14:0/14:0)
Not Available
  • DAG(14:0/14:1)
Not Available
  • Diacylglycerol(29:0)
Not Available
  • DAG(30:0)
Not Available
  • DG(30:1)
Not Available
genes like me logo Genes that share compounds with RASGRP4: view

Transcripts for RASGRP4 Gene

Unigene Clusters for RASGRP4 Gene

RAS guanyl releasing protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASGRP4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP4 Gene

No ASD Table

Relevant External Links for RASGRP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASGRP4 Gene

mRNA expression in normal human tissues for RASGRP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGRP4 Gene

This gene is overexpressed in Whole Blood (41.3).

Protein differential expression in normal tissues for RASGRP4 Gene

This gene is overexpressed in Cervix (25.5), Monocytes (13.0), Tlymphocyte (10.3), Heart (9.4), and Neutrophil (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASGRP4 Gene

SOURCE GeneReport for Unigene cluster for RASGRP4 Gene Hs.130434

mRNA Expression by UniProt/SwissProt for RASGRP4 Gene

Tissue specificity: Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
genes like me logo Genes that share expressions with RASGRP4: view

Expression partners for RASGRP4 Gene

In Situ Assay Products

Orthologs for RASGRP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGRP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASGRP4 35
  • 88.16 (n)
  • 88.86 (a)
  • 89 (a)
(Canis familiaris)
Mammalia RASGRP4 35
  • 88.96 (n)
  • 90.64 (a)
  • 95 (a)
(Mus musculus)
Mammalia Rasgrp4 35
  • 83.78 (n)
  • 86.12 (a)
Rasgrp4 16
Rasgrp4 36
  • 85 (a)
(Pan troglodytes)
Mammalia RASGRP4 35
  • 99.26 (n)
  • 99.41 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rasgrp4 35
  • 82.64 (n)
  • 83.43 (a)
(Monodelphis domestica)
Mammalia RASGRP4 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia RASGRP4 36
  • 52 (a)
(Anolis carolinensis)
Reptilia RASGRP4 36
  • 55 (a)
(Danio rerio)
Actinopterygii rasgrp4 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea rgef-1 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for RASGRP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RASGRP4 Gene

Gene Tree for RASGRP4 (if available)
Gene Tree for RASGRP4 (if available)

Paralogs for RASGRP4 Gene

Paralogs for RASGRP4 Gene

Selected SIMAP similar genes for RASGRP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASGRP4: view

Variants for RASGRP4 Gene

Sequence variations from dbSNP and Humsavar for RASGRP4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs892055 - 38,422,124(+) CTCCT(A/G)TTTTT missense, reference
rs1079161 -- 38,411,655(+) TACCA(C/T)GGCAC intron-variant
rs1079162 -- 38,411,806(+) CAAGA(A/G)TTGTC intron-variant
rs3810342 -- 38,416,945(-) ACCAC(A/C)TGAAG intron-variant
rs4075613 -- 38,412,459(-) ACAAT(C/T)GCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASGRP4 Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV Loss 17160897
nsv911658 CNV Loss 21882294
nsv470140 CNV Gain 18288195
nsv911659 CNV Loss 21882294
nsv911660 CNV Gain 21882294
nsv833823 CNV Loss 17160897
dgv3858n71 CNV Loss 21882294
nsv833824 CNV Loss 17160897

Relevant External Links for RASGRP4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRP4 Gene

Disorders for RASGRP4 Gene

Relevant External Links for RASGRP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RASGRP4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RASGRP4 Gene

Publications for RASGRP4 Gene

  1. The diacylglycerol-dependent translocation of ras guanine nucleotide- releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2. (PMID: 18024961) Katsoulotos G.P. … Krilis S.A. (J. Biol. Chem. 2008) 3 4 23
  2. RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. (PMID: 11956218) Yang Y. … Stevens R.L. (J. Biol. Chem. 2002) 2 3 4
  3. RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia. (PMID: 11880369) Reuther G.W. … Der C.J. (J. Biol. Chem. 2002) 3 4 23
  4. RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines. (PMID: 12493770) Li L. … Stevens R.L. (J. Biol. Chem. 2003) 3 4 23
  5. Variants in several genomic regions associated with asperger disorder. (PMID: 21182207) Salyakina D. … Pericak-Vance M.A. (Autism Res 2010) 3 48

Products for RASGRP4 Gene

Sources for RASGRP4 Gene

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