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RASGRP4 Gene

protein-coding   GIFtS: 57
GCID: GC19M038899

RAS Guanyl Releasing Protein 4

  Search for RASGRP4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAS Guanyl Releasing Protein 41 2
Guanyl Nucleotide Releasing Protein 42
RAS Guanyl-Releasing Protein 42

External Ids:    HGNC: 189581   Entrez Gene: 1157272   Ensembl: ENSG000001717777   OMIM: 6073205   UniProtKB: Q8TDF63   

Export aliases for RASGRP4 gene to outside databases

Previous GC identifers: GC19M039514 GC19M039291 GC19M043575 GC19M043591 GC19M035347


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RASGRP4 Gene:
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras
guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two
calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro.
Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS
protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of
this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line
expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an
important role in the final stages of mast cell development. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Apr 2009)

GeneCards Summary for RASGRP4 Gene:
RASGRP4 (RAS guanyl releasing protein 4) is a protein-coding gene. GO annotations related to this gene include GTP-dependent protein binding and calcium ion binding. An important paralog of this gene is UNC13C.

UniProtKB/Swiss-Prot: GRP4_HUMAN, Q8TDF6
Function: Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras
through the exchange of bound GDP for GTP. May function in mast cells differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASGRP4 gene promoter:
         CREB   p53   NRSF form 1   deltaCREB   POU3F2   NRSF form 2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASGRP4 promoter sequence
   Search Chromatin IP Primers for RASGRP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASGRP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

RASGRP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASGRP4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M038899:  view genomic region     (about GC identifiers)

Start:
38,899,695 bp from pter      End:
38,916,945 bp from pter
Size:
17,251 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GRP4_HUMAN, Q8TDF6 (See protein sequence)
Recommended Name: RAS guanyl-releasing protein 4  
Size: 673 amino acids; 74882 Da
Developmental stage: Expressed early during development. Detected in all fetal tissues tested
Secondary accessions: A6H8M4 C0LTP2 C0LTP3 C0LTP4 C0LTP5 C0LTP7 C9J416 C9JHZ1 Q8N858 Q96QN5
Q96QN6 Q96QN7
Alternative splicing: 8 isoforms:  Q8TDF6-1   Q8TDF6-2   Q8TDF6-3   Q8TDF6-5   Q8TDF6-6   Q8TDF6-7   Q8TDF6-8   Q8TDF6-9   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RASGRP4: NX_Q8TDF6

Explore proteomics data for RASGRP4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASGRP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001139674.1  NP_001139675.1  NP_001139676.1  NP_001139677.1  NP_001139678.1  NP_001139679.1  NP_733749.1  

    ENSEMBL proteins: 
     ENSP00000467604   ENSP00000466928   ENSP00000411878   ENSP00000445966   ENSP00000468483  
     ENSP00000416463   ENSP00000293062   ENSP00000465742   ENSP00000465772  
    Reactome Protein details: Q8TDF6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    Selected InterPro protein domains (see all 7):
     IPR008937 Ras_GEF
     IPR002048 EF_hand_dom
     IPR020454 DAG/PE-bd
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25

    Graphical View of Domain Structure for InterPro Entry Q8TDF6

    ProtoNet protein and cluster: Q8TDF6

    1 Blocks protein domain: IPB001895 Guanine-nucleotide dissociation stimulator CDC25

    UniProtKB/Swiss-Prot: GRP4_HUMAN, Q8TDF6
    Domain: The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG
    Similarity: Belongs to the RASGRP family
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 Ras-GEF domain


    Find genes that share domains with RASGRP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRP4_HUMAN, Q8TDF6
    Function: Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras
    through the exchange of bound GDP for GTP. May function in mast cells differentiation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005088Ras guanyl-nucleotide exchange factor activity IDA11880369
    GO:0005509calcium ion binding IEA--
    GO:0019992diacylglycerol binding TAS11880369
    GO:0030742GTP-dependent protein binding NAS11880369
         
    Find genes that share ontologies with RASGRP4           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rasgrp4):
     cellular  digestive/alimentary  hematopoietic system  immune system  skeleton 

    Find genes that share phenotypes with RASGRP4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RASGRP4: Rasgrp4tm1d(KOMP)Lste Rasgrp4tm1(cre)Rls

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    SwitchGear 3'UTR luciferase reporter plasmidRASGRP4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRP4_HUMAN, Q8TDF6: Cytoplasm. Cell membrane. Note=Recruited to membranes upon activation by DAG
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS11880369
    GO:0016020membrane IDA11880369

    Find genes that share ontologies with RASGRP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RASGRP4 About    
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2PI-3K cascade
    Fc epsilon receptor (FCERI) signaling0.64
    3Ras signaling pathway
    Ras signaling pathway0.36
    4Creation of C4 and C2 activators
    FCERI mediated NF-kB activation0.32
    5G protein signaling H RAS regulation pathway
    G protein signaling H RAS regulation pathway


    Find genes that share SuperPaths with RASGRP4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RASGRP4
        G-protein signaling H-RAS regulation pathway

    1 BioSystems Pathway for RASGRP4
        MAPK signaling pathway

    1 Reactome Pathway for RASGRP4
        FCERI mediated NF-kB activation


    2 Kegg Pathways  (Kegg details for RASGRP4):
        MAPK signaling pathway
    Ras signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASGRP4
    Interactions:

        GeneGlobe Interaction Network for RASGRP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RASGRP4 (Q8TDF63 ENSP000004164634) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=1 STRING: ENSP00000309845
    RAP1AP628343, ENSP000003487864I2D: score=1 STRING: ENSP00000348786
    NRASENSP000003585484STRING: ENSP00000358548
    CACNA1AENSP000003533624STRING: ENSP00000353362
    CACNA1BENSP000002775494STRING: ENSP00000277549
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway NAS11880369
    GO:0007202activation of phospholipase C activity NAS11880369
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway NAS11880369
    GO:0008283cell proliferation IDA11880369

    Find genes that share ontologies with RASGRP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RASGRP4 (GRP4)

    Selected HMDB Compounds for RASGRP4 (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RASGRP4 gene (10 alternative transcripts): 
    NM_001146202.1  NM_001146203.1  NM_001146204.1  NM_001146205.1  NM_001146206.1  NM_001146207.1  NM_170604.2  NM_052949.2  
    NM_170602.1  NM_170603.1  

    Unigene Cluster for RASGRP4:

    RAS guanyl releasing protein 4
    Hs.130434  [show with all ESTs]
    Unigene Representative Sequence: BC142721
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586305 ENST00000588708 ENST00000589474 ENST00000433821(uc021uuc.1)
    ENST00000426920(uc021uue.1) ENST00000587753 ENST00000454404(uc010efz.2 uc010ega.2 uc021utz.1 uc021uua.1 uc021uub.1 uc021uuf.1)
    ENST00000293062(uc021uud.1) ENST00000589358 ENST00000592322 ENST00000588404
    ENST00000587287 ENST00000587738 ENST00000589100
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    Additional mRNA sequence: 

    AF448437.1 BC142721.1 BC146669.1 BC150202.1 BC151216.1 FJ768677.1 FJ768678.1 FJ768679.1 
    FJ768680.1 FJ768682.1 

    6 DOTS entries:

    DT.91747394  DT.95282217  DT.91747393  DT.95283973  DT.401803  DT.100746721 

    Selected AceView cDNA sequences (see all 30):

    AF448437 NM_170602 NM_170603 NM_170604 NM_052949 AI638376 AL542374 AY048120 
    AA923524 AI792785 D31124 AK097292 BM148824 BU102146 AY048121 AY048119 
    BM147825 BX107750 AA740464 AL569386 AI733142 BM149851 BQ028385 D20087 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASGRP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCACCAGC
    RASGRP4 Expression
    About this image


    RASGRP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Mast cell progenitor cells Hematopoietic Bone Marrow
             neutrophils   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             bone marrow   
     
     Eye (Sensory Organs)
             Retina
    RASGRP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASGRP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.130434

    UniProtKB/Swiss-Prot: GRP4_HUMAN, Q8TDF6
    Tissue specificity: Expressed by mast cells and their progenitors (at protein level). Specifically expressed in
    mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart,
    skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in
    normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more
    significantly expressed in a patient with asthma and a mastocytosis patient

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASGRP4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasgrp41 , 5 RAS guanyl releasing protein 41, 5 83.78(n)1
    86.12(a)1
      7 (16.94 cM)5
    2330461  NM_001174155.11  NP_001167626.11 
     291348545 
    lizard
    (Anolis carolinensis)
    Reptilia RASGRP46
    RAS guanyl releasing protein 4
    55(a)
    1 ↔ 1
    GL343427.1(474256-502857)
    zebrafish
    (Danio rerio)
    Actinopterygii rasgrp46
    RAS guanyl releasing protein 4
    45(a)
    1 ↔ 1
    18(34082674-34142319) ENSDARG00000061796
    worm
    (Caenorhabditis elegans)
    Secernentea rgef-16
    Protein RGEF-1, isoform b (rgef-1) mRNA, complete ...
    29(a)
    1 → many
    V(9556716-9561643) WBGene00009100


    ENSEMBL Gene Tree for RASGRP4 (if available)
    TreeFam Gene Tree for RASGRP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASGRP4 gene
    UNC13C2  UNC13A2  RASGRP12  RASGRP22  UNC13B2  RASGRP32  
    4 SIMAP similar genes for RASGRP4 using alignment to 2 protein entries:     GRP4_HUMAN (see all proteins):
    PRKD1    RASGRP1    RASGRP3    RASGRP2

    Find genes that share paralogs with RASGRP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASGRP4 (see all 489)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915201531,2
    --38900234(+) TTAGCC/TGGGCA 7 -- ut310--------
    rs1837569571,2
    --38900328(+) AGCTGA/GGATTG 7 -- ut310--------
    rs1861646801,2
    C--38900346(+) GCACTC/TCAGCC 7 -- ut310--------
    rs1505081481,2
    --38900451(+) ACAGCC/TGCACA 7 -- ut310--------
    rs1914529421,2
    C--38900575(+) AAGGCA/GGATGC 7 -- ut310--------
    rs1416220481,2
    C--38900728(+) ACCGGC/GCAGGG 14 C W mis10--------
    rs1828154291,2
    --38900863(+) CCCTGC/TGGAAT 7 -- int10--------
    rs1867706901,2
    --38900892(+) TGAGAC/GTCTCT 7 -- int10--------
    rs1152419941,2
    F--38900930(+) TAACCC/TGTACA 7 -- int11Minor allele frequency- T:0.01WA 118
    rs743872921,2
    C,F--38900947(+) CCTGAT/AATATT 7 -- int11Minor allele frequency- A:0.03EA 120

    HapMap Linkage Disequilibrium report for RASGRP4 (38899695 - 38916945 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RASGRP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833823CNV Loss17160897
    dgv3858n71CNV Loss21882294
    nsv911658CNV Loss21882294
    nsv911659CNV Loss21882294
    nsv833824CNV Loss17160897
    nsv833822CNV Loss17160897
    nsv911660CNV Gain21882294
    nsv470140CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASGRP4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607320    OMIM disorders: --


    Find genes that share disorders with RASGRP4           About GenesLikeMe

    Genetic Association Database (GAD): RASGRP4
    Human Genome Epidemiology (HuGE) Navigator: RASGRP4 (1 document)

    Export disorders for RASGRP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASGRP4 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with RASGRP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. (PubMed id 11956218)1, 2, 3 Yang Y....Stevens R.L. (J. Biol. Chem. 2002)
    2. RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia. (PubMed id 11880369)1, 2, 9 Reuther G.W.... Der C.J. (J. Biol. Chem. 2002)
    3. The diacylglycerol-dependent translocation of ras guanine nucleotide- releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2. (PubMed id 18024961)1, 2, 9 Katsoulotos G.P.... Krilis S.A. (J. Biol. Chem. 2008)
    4. RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines. (PubMed id 12493770)1, 2, 9 Li L.... Stevens R.L. (J. Biol. Chem. 2003)
    5. Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis. (PubMed id 21933395)1, 2 Hashimoto T....Koike T. (Arthritis Res. Ther. 2011)
    6. Variants in several genomic regions associated with asperger disorder. (PubMed id 21182207)1, 4 Salyakina D....Pericak-Vance M.A. (Autism Res 2010)
    7. GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. (PubMed id 22728827)1 Suire S....Stephens L. (EMBO J. 2012)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. Possible involvement of RasGRP4 in leukemogenesis. (PubMed id 19350351)1 Watanabe-Okochi N....Kitamura T. (Int. J. Hematol. 2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115727 HGNC: 18958 AceView: RASGRP4 Ensembl:ENSG00000171777 euGenes: HUgn115727
    ECgene: RASGRP4 Kegg: 115727 H-InvDB: RASGRP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RASGRP4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASGRP4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RASGRP4 gene:
    Search GeneIP for patents involving RASGRP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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