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Aliases for RASGRP4 Gene

Aliases for RASGRP4 Gene

  • RAS Guanyl Releasing Protein 4 2 3 5

External Ids for RASGRP4 Gene

Previous GeneCards Identifiers for RASGRP4 Gene

  • GC19M039514
  • GC19M039291
  • GC19M043575
  • GC19M043591
  • GC19M038899
  • GC19M035347

Summaries for RASGRP4 Gene

Entrez Gene Summary for RASGRP4 Gene

  • The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for RASGRP4 Gene

RASGRP4 (RAS Guanyl Releasing Protein 4) is a Protein Coding gene. Diseases associated with RASGRP4 include Mast-Cell Leukemia and Mastocytosis. Among its related pathways are RET signaling and Immune System. GO annotations related to this gene include calcium ion binding and GTP-dependent protein binding. An important paralog of this gene is RASGRP1.

UniProtKB/Swiss-Prot for RASGRP4 Gene

  • Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRP4 Gene

Genomics for RASGRP4 Gene

Regulatory Elements for RASGRP4 Gene

Enhancers for RASGRP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F038312 1.8 FANTOM5 Ensembl ENCODE 9.3 +108.7 108714 10.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 C19orf33 ENSG00000266963 CATSPERG SPINT2 ENSG00000269445 ENSG00000267375 ENSG00000269172 ENSG00000269688 PPP1R14A ACTN4
GH19F038543 1.4 Ensembl ENCODE 10.8 -118.4 -118357 2.3 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF143 ZNF607 ZNF573 ZNF571 ENSG00000269688 RN7SL566P RPS16 LOC100631378 ZNF781 FAM98C SUPT5H
GH19F038426 0.7 FANTOM5 19.1 +0.8 802 0.1 ZMYM3 ZIC2 HIC1 ZFHX2 GLIS2 POLR2A PRDM10 KDM1A EGR2 ZBTB20 RASGRP4 NFKBIB RINL GC19P038425
GH19F038373 1.2 ENCODE 10.2 +50.9 50913 3.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 RN7SL566P CATSPERG KCNK6 ZNF573 ENSG00000269688 FBXO17 FAM98C YIF1B PPP1R14A SPINT2
GH19F038233 0.9 ENCODE 10.6 +192.3 192310 0.2 PKNOX1 KLF17 ARID4B ZNF48 ZNF2 RAD21 ZNF121 GLIS2 SCRT2 ZNF143 YIF1B PPP1R14A KCNK6 CATSPERG RASGRP4 RYR1 GGN SPRED3 FAM98C DPF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASGRP4 on UCSC Golden Path with GeneCards custom track

Promoters for RASGRP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216431 405 601 EBF1 ZIC2 ZNF121 GLIS2 EED PRDM10 ZNF740 RNF2 ZBTB11 JUNB

Genomic Location for RASGRP4 Gene

Chromosome:
19
Start:
38,409,051 bp from pter
End:
38,426,305 bp from pter
Size:
17,255 bases
Orientation:
Minus strand

Genomic View for RASGRP4 Gene

Genes around RASGRP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASGRP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASGRP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRP4 Gene

Proteins for RASGRP4 Gene

  • Protein details for RASGRP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDF6-GRP4_HUMAN
    Recommended name:
    RAS guanyl-releasing protein 4
    Protein Accession:
    Q8TDF6
    Secondary Accessions:
    • A6H8M4
    • C0LTP2
    • C0LTP3
    • C0LTP4
    • C0LTP5
    • C0LTP7
    • C9J416
    • C9JHZ1
    • Q8N858
    • Q96QN5
    • Q96QN6
    • Q96QN7

    Protein attributes for RASGRP4 Gene

    Size:
    673 amino acids
    Molecular mass:
    74882 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RASGRP4 Gene

neXtProt entry for RASGRP4 Gene

Post-translational modifications for RASGRP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RASGRP4 Gene

Domains & Families for RASGRP4 Gene

Gene Families for RASGRP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDF6

UniProtKB/Swiss-Prot:

GRP4_HUMAN :
  • The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.
  • Belongs to the RASGRP family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.
  • Contains 1 EF-hand domain.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
Family:
  • Belongs to the RASGRP family.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with RASGRP4: view

Function for RASGRP4 Gene

Molecular function for RASGRP4 Gene

UniProtKB/Swiss-Prot Function:
Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.

Gene Ontology (GO) - Molecular Function for RASGRP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0019992 diacylglycerol binding TAS 11880369
GO:0030742 GTP-dependent protein binding NAS 11880369
genes like me logo Genes that share ontologies with RASGRP4: view
genes like me logo Genes that share phenotypes with RASGRP4: view

Animal Models for RASGRP4 Gene

MGI Knock Outs for RASGRP4:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RASGRP4 Gene

Localization for RASGRP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASGRP4 Gene

Cytoplasm. Cell membrane. Note=Recruited to membranes upon activation by DAG.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASGRP4 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for RASGRP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS 11880369
GO:0016020 membrane IEA,IDA 11880369
genes like me logo Genes that share ontologies with RASGRP4: view

Pathways & Interactions for RASGRP4 Gene

SuperPathways for RASGRP4 Gene

SuperPathway Contained pathways
1 RET signaling
2 MAPK signaling pathway
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Immune System
genes like me logo Genes that share pathways with RASGRP4: view

Pathways by source for RASGRP4 Gene

1 GeneGo (Thomson Reuters) pathway for RASGRP4 Gene

Gene Ontology (GO) - Biological Process for RASGRP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS 11880369
GO:0007202 activation of phospholipase C activity NAS 11880369
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway NAS 11880369
genes like me logo Genes that share ontologies with RASGRP4: view

No data available for SIGNOR curated interactions for RASGRP4 Gene

Drugs & Compounds for RASGRP4 Gene

(1) Drugs for RASGRP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for RASGRP4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with RASGRP4: view

Transcripts for RASGRP4 Gene

Unigene Clusters for RASGRP4 Gene

RAS guanyl releasing protein 4:
Representative Sequences: