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RASGRP3 Gene

protein-coding   GIFtS: 64
GCID: GC02P033661

RAS Guanyl Releasing Protein 3 (Calcium And DAG-Regulated)

  Search for RASGRP3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RAS Guanyl Releasing Protein 3 (Calcium And DAG-Regulated)1 2
Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor III2 3
Guanine Nucleotide Exchange Factor For Rap12 3
GRP32 3
Ras Guanyl-Releasing Protein 32
KIAA08463

External Ids:    HGNC: 145451   Entrez Gene: 257802   Ensembl: ENSG000001526897   OMIM: 6095315   UniProtKB: Q8IV613   
ORGUL members:         

Export aliases for RASGRP3 gene to outside databases

Previous GC identifers: GC02P033619 GC02P033635 GC02P033573 GC02P033514 GC02P033395


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RASGRP3 Gene:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as
GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide
exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the
active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al.,
2000 (PubMed 10934204)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RASGRP3 Gene:
RASGRP3 (RAS guanyl releasing protein 3 (calcium and DAG-regulated)) is a protein-coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and calcium ion binding. An important paralog of this gene is UNC13C.

UniProtKB/Swiss-Prot: GRP3_HUMAN, Q8IV61
Function: Guanine nucleotide exchange factor (GEF) for Ras and Rap1

Gene Wiki entry for RASGRP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASGRP3 gene promoter:
         SRF   Sox5   SRF (504 AA)   STAT5A   CUTL1   NF-kappaB   MEF-2A   SRY   aMEF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RASGRP3 promoter sequence
   Search Chromatin IP Primers for RASGRP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASGRP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1-p24.1   Ensembl cytogenetic band:  2p22.3   HGNC cytogenetic band: 2p25.1-p24.1

RASGRP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASGRP3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P033661:  view genomic region     (about GC identifiers)

Start:
33,661,391 bp from pter      End:
33,789,817 bp from pter
Size:
128,427 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GRP3_HUMAN, Q8IV61 (See protein sequence)
Recommended Name: Ras guanyl-releasing protein 3  
Size: 690 amino acids; 78332 Da
Sequence caution: Sequence=BAA74869.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D6W583 O94931 Q53SD7
Alternative splicing: 2 isoforms:  Q8IV61-1   Q8IV61-2   

Explore the universe of human proteins at neXtProt for RASGRP3: NX_Q8IV61

Explore proteomics data for RASGRP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASGRP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001132960.1  NP_056191.1  NP_733772.1  

    ENSEMBL proteins: 
     ENSP00000385886   ENSP00000393866   ENSP00000384192   ENSP00000405648   ENSP00000401974  
     ENSP00000400602   ENSP00000388139   ENSP00000383917   ENSP00000409593  
    Reactome Protein details: Q8IV61

    RASGRP3 Human Recombinant Protein Products:

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    Novus Biologicals RASGRP3 Proteins
    Novus Biologicals RASGRP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for RASGRP3

     
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    Search eBioscience for ELISAs for RASGRP3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    Selected InterPro protein domains (see all 9):
     IPR008937 Ras_GEF
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR020454 DAG/PE-bd
     IPR023578 Ras_GEF_dom

    Graphical View of Domain Structure for InterPro Entry Q8IV61

    ProtoNet protein and cluster: Q8IV61

    1 Blocks protein domain: IPB001895 Guanine-nucleotide dissociation stimulator CDC25

    UniProtKB/Swiss-Prot: GRP3_HUMAN, Q8IV61
    Similarity: Belongs to the RASGRP family
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 Ras-GEF domain


    Find genes that share domains with RASGRP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRP3_HUMAN, Q8IV61
    Function: Guanine nucleotide exchange factor (GEF) for Ras and Rap1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS10934204
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
    GO:0005088Ras guanyl-nucleotide exchange factor activity IEA--
    GO:0005509calcium ion binding NAS10934204
    GO:0017016Ras GTPase binding IEA--
         
    Find genes that share ontologies with RASGRP3           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rasgrp3):
     hematopoietic system  immune system  normal 

    Find genes that share phenotypes with RASGRP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rasgrp3tm1Jstn for RASGRP3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASGRP3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASGRP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASGRP3

    miRNA
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    miRTarBase miRNAs that target RASGRP3:
    hsa-mir-21-5p (MIRT030769)

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    Selected qRT-PCR Assays for microRNAs that regulate RASGRP3 (see all 15):
    hsa-miR-30c hsa-miR-3163 hsa-miR-4324 hsa-miR-30d hsa-miR-340 hsa-miR-373* hsa-miR-30a hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidRASGRP3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat RASGRP3

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS10934204
    GO:0032045guanyl-nucleotide exchange factor complex IEA--

    Find genes that share ontologies with RASGRP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RASGRP3 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Downstream Signaling Events Of B Cell Receptor (BCR)
    Downstream Signaling Events Of B Cell Receptor (BCR)0.79
    Activation of RAS in B Cells0.00
    Signaling by the B Cell Receptor (BCR)0.79
    2G protein signaling TC21 regulation pathway
    G protein signaling TC21 regulation pathway0.71
    G protein signaling M RAS regulation pathway0.71
    3Ras signaling pathway
    Rap1 signaling pathway0.36
    Ras signaling pathway0.36
    4TCR Signaling (Qiagen)
    ITK and TCR Signaling0.54
    5MAPK signaling pathway
    MAPK signaling pathway0.50


    Find genes that share SuperPaths with RASGRP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RASGRP3
        ITK and TCR Signaling

    2 Cell Signaling Technology (CST) Pathways for RASGRP3
        MAP Kinase Signaling
    Cytoskeletal Signaling

    4 GeneGo (Thomson Reuters) Pathways for RASGRP3
        G-protein signaling H-RAS regulation pathway
    G-protein signaling TC21 regulation pathway
    G-protein signaling M-RAS regulation pathway
    G-protein signaling Rap1A regulation pathway

    2 BioSystems Pathways for RASGRP3
        Integrated Breast Cancer Pathway
    B Cell Receptor Signaling Pathway

    1 Reactome Pathway for RASGRP3
        Activation of RAS in B cells


    4 Kegg Pathways  (Kegg details for RASGRP3):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    B cell receptor signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASGRP3
    Interactions:

        Search GeneGlobe Interaction Network for RASGRP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RASGRP3 (Q8IV613 ENSP000003841924) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCBP057713, ENSP000003053554I2D: score=3 STRING: ENSP00000305355
    PRKCDQ056553, ENSP000003316024I2D: score=3 STRING: ENSP00000331602
    PRKCQQ047593, ENSP000002631254I2D: score=2 STRING: ENSP00000263125
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    PIK3CAP423363, ENSP000002639674I2D: score=1 STRING: ENSP00000263967
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade NAS10934204
    GO:0007264small GTPase mediated signal transduction TAS10934204
    GO:0007265Ras protein signal transduction IEA--
    GO:0032854positive regulation of Rap GTPase activity IDA10934204
    GO:0035556intracellular signal transduction ----

    Find genes that share ontologies with RASGRP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASGRP3 (GRP3)

    Selected HMDB Compounds for RASGRP3 (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RASGRP3 gene (3 alternative transcripts): 
    NM_001139488.1  NM_015376.2  NM_170672.2  

    Unigene Cluster for RASGRP3:

    RAS guanyl releasing protein 3 (calcium and DAG-regulated)
    Hs.143674  [show with all ESTs]
    Unigene Representative Sequence: NM_001139488
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402538(uc002rox.3) ENST00000484909(uc002row.1) ENST00000497723
    ENST00000479528 ENST00000437184 ENST00000403687(uc010ync.2) ENST00000482857
    ENST00000442390 ENST00000425210 ENST00000444784 ENST00000423159 ENST00000494927
    ENST00000407811(uc002roy.3) ENST00000477927 ENST00000490150 ENST00000419772
    ENST00000468856 ENST00000482731
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    hsa-miR-30c hsa-miR-3163 hsa-miR-4324 hsa-miR-30d hsa-miR-340 hsa-miR-373* hsa-miR-30a hsa-miR-544b
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    Additional mRNA sequence: 

    AB020653.1 AK124316.1 AK125551.1 AK292983.1 BC027849.1 BX647990.1 

    14 DOTS entries:

    DT.101956867  DT.99932307  DT.456370  DT.70105047  DT.100016628  DT.99938872  DT.86845183  DT.86852875 
    DT.121005150  DT.40225859  DT.75173374  DT.91707627  DT.91707649  DT.91855304 

    Selected AceView cDNA sequences (see all 124):

    AK124316 AI803282 BQ049851 NM_170672 AW188004 W01365 AI521153 AW504122 
    AK125551 AI361501 AI203954 AI221645 AI868726 AW452373 AW005810 BC027849 
    AA911204 BM994037 BQ026850 BX098420 CA335019 AA479057 AI094156 BG754699 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP3 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:                    -     -     -     -     -     -                 -                       -     -                                                         
    SP2:                                            -     -                 -                       -     -                                                         
    SP3:                                                                                            -     -                                                         
    SP4:                          -     -     -     -     -                 -                       -     -                                                         
    SP5:                                                  -     -           -                       -     -                                                         

    ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c
    SP1:  -                                                   
    SP2:  -                                                   
    SP3:  -                                                   
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for RASGRP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RASGRP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAACAACAT
    RASGRP3 Expression
    About this image


    RASGRP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     NULL (Uncategorized)
             Mesoderm-like cells
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Dermis (Integumentary System)
    RASGRP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASGRP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143674
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGRP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASGRP3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasgrp31 , 5 RAS, guanyl releasing protein 31, 5 89.28(n)1
    94.35(a)1
      17 (46.55 cM)5
    2401681  NM_001166493.11  NP_001159965.11 
     754359055 
    chicken
    (Gallus gallus)
    Aves RASGRP31 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 80.49(n)
    87.63(a)
      421460  NM_001006401.1  NP_001006401.1 
    lizard
    (Anolis carolinensis)
    Reptilia RASGRP36
    RAS guanyl releasing protein 3 (calcium and DAG-re...
    86(a)
    1 ↔ 1
    1(231359792-231390524)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rasgrp31 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 75(n)
    80.29(a)
      100487452  XM_002934450.2  XP_002934496.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rasgrp31 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 70.5(n)
    75.85(a)
      563441  NM_001110464.1  NP_001103934.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rgef-11 rgef-1 50.19(n)
    41.44(a)
      179344  NM_073068.3  NP_505469.3 


    ENSEMBL Gene Tree for RASGRP3 (if available)
    TreeFam Gene Tree for RASGRP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASGRP3 gene
    UNC13C2  RASGRP42  UNC13A2  RASGRP12  RASGRP22  UNC13B2  
    5 SIMAP similar genes for RASGRP3 using alignment to 7 protein entries:     GRP3_HUMAN (see all proteins):
    RASGRP1    PRKD1    RASGRP2    RASGRP4    DKFZp781H1715

    Find genes that share paralogs with RASGRP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASGRP3 (see all 3234)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868841971,2
    --33659498(+) CAAAAC/GAATAA 1 -- us2k10--------
    rs1387927221,2
    C--33659676(+) CCGGGC/TGTGGT 1 -- us2k10--------
    rs6834731,2
    C,F--33659688(-) caggcA/Gtgtgc 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs6099941,2
    C,F--33659748(-) ACCTCC/TGCCTC 1 -- us2k12Minor allele frequency- T:0.25NA CSA 4
    rs3714986051,2
    C--33659815(+) CTGTC-/CAAA  
            
    AAACA
    1 -- us2k10--------
    rs1153457841,2
    C,F--33659841(+) TGGGGG/TCTGGG 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1905952141,2
    --33659874(+) TTCATA/TTCTTC 1 -- us2k10--------
    rs1834849451,2
    --33659955(+) AATTTA/GTCTAT 1 -- us2k10--------
    rs1485700971,2
    --33660150(+) AAAAGC/TATATA 1 -- us2k10--------
    rs1888198031,2
    --33660179(+) ACATTA/TAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RASGRP3 (33661391 - 33789817 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RASGRP3 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2462414CNV Deletion19546169
    nsv820684CNV Deletion20802225
    esv2661374CNV Deletion23128226
    esv4426CNV Deletion18987735
    nsv435723CNV Deletion17901297
    esv2719890CNV Deletion23290073
    esv2199255CNV Deletion18987734
    nsv516338CNV Loss19592680
    nsv873792CNV Loss21882294
    nsv517737CNV Loss19592680

    Human Gene Mutation Database (HGMD): RASGRP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASGRP3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609531    OMIM disorders: --


    Find genes that share disorders with RASGRP3           About GenesLikeMe

    Genetic Association Database (GAD): RASGRP3
    Human Genome Epidemiology (HuGE) Navigator: RASGRP3 (4 documents)

    Export disorders for RASGRP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASGRP3 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with RASGRP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PubMed id 10934204)1, 2, 3, 9 Rebhun J.F.... Quilliam L.A. (J. Biol. Chem. 2000)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    3. TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population. (PubMed id 20516000)1, 4 He C.F....Yang S. (Lupus 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PubMed id 19838193)1, 4 Han J.W....Zhang X.J. (Nat. Genet. 2009)
    6. Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. (PubMed id 19421330)1, 4 Yang H.C....Pan W.H. (PLoS ONE 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. (PubMed id 15572660)1, 9 Roberts D.M....Bautch V.L. (Mol. Cell. Biol. 2004)
    9. Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. (PubMed id 12730099)1, 9 Teixeira C....Stone J.C. (Blood 2003)
    10. Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. (PubMed id 15657177)1, 9 Zheng Y.... Stone J.C. (Blood 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25780 HGNC: 14545 AceView: RASGRP3 Ensembl:ENSG00000152689 euGenes: HUgn25780
    ECgene: RASGRP3 Kegg: 25780 H-InvDB: RASGRP3

    (According to HUGE)
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    HUGE: KIAA0846

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RASGRP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RASGRP3 gene:
    Search GeneIP for patents involving RASGRP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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