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Aliases for RASGRP3 Gene

Aliases for RASGRP3 Gene

  • RAS Guanyl Releasing Protein 3 2 3 5
  • Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor III 2 3
  • Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor III 3 4
  • RAS Guanyl Releasing Protein 3 (Calcium And DAG-Regulated) 2 3
  • Guanine Nucleotide Exchange Factor For Rap1 3 4
  • GRP3 3 4
  • Ras Guanyl-Releasing Protein 3 3
  • KIAA0846 4

External Ids for RASGRP3 Gene

Previous GeneCards Identifiers for RASGRP3 Gene

  • GC02P033619
  • GC02P033635
  • GC02P033573
  • GC02P033514
  • GC02P033395
  • GC02P033661

Summaries for RASGRP3 Gene

Entrez Gene Summary for RASGRP3 Gene

  • Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RASGRP3 Gene

RASGRP3 (RAS Guanyl Releasing Protein 3) is a Protein Coding gene. Among its related pathways are RET signaling and Integrated Breast Cancer Pathway. GO annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is RASGRP1.

UniProtKB/Swiss-Prot for RASGRP3 Gene

  • Guanine nucleotide exchange factor (GEF) for Ras and Rap1.

Gene Wiki entry for RASGRP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRP3 Gene

Genomics for RASGRP3 Gene

Regulatory Elements for RASGRP3 Gene

Enhancers for RASGRP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F033554 1.1 Ensembl ENCODE 26.3 +118.9 118877 1.7 ZFHX2 MAX GABPA NR2F2 EGR2 RASGRP3 LOC105374454
GH02F033474 1.3 FANTOM5 ENCODE 25.1 +41.5 41502 6.1 PKNOX1 ATF1 WRNIP1 SIN3A FEZF1 ZNF48 YY1 GATA2 ZNF143 JUNB RASGRP3 LOC105374454
GH02F033529 1.2 Ensembl ENCODE 25 +95.1 95101 4.1 CTCF TBP PKNOX1 CBX3 TBL1XR1 ASH2L ZMYM3 YY1 RELA POLR2A RASGRP3 LOC105374454
GH02F033411 1.4 Ensembl ENCODE 12.8 -24.2 -24167 1.7 CTCF ATF1 JUN CHD4 ZIC2 RAD21 ZKSCAN1 GATA3 SMC3 FOS RASGRP3 ENSG00000206951 LTBP1 MIR4430 PIR50335
GH02F033582 0.4 Ensembl 10 +146.0 145977 0.6 RASGRP3 GC02P033576 GC02P033593
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RASGRP3 on UCSC Golden Path with GeneCards custom track

Promoters for RASGRP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000300415 176 201

Genomic Location for RASGRP3 Gene

33,436,324 bp from pter
33,564,750 bp from pter
128,427 bases
Plus strand

Genomic View for RASGRP3 Gene

Genes around RASGRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASGRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASGRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRP3 Gene

Proteins for RASGRP3 Gene

  • Protein details for RASGRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras guanyl-releasing protein 3
    Protein Accession:
    Secondary Accessions:
    • D6W583
    • O94931
    • Q53SD7

    Protein attributes for RASGRP3 Gene

    690 amino acids
    Molecular mass:
    78332 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74869.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASGRP3 Gene


neXtProt entry for RASGRP3 Gene

Post-translational modifications for RASGRP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RASGRP3 (RASGRP3)

No data available for DME Specific Peptides for RASGRP3 Gene

Domains & Families for RASGRP3 Gene

Gene Families for RASGRP3 Gene

Suggested Antigen Peptide Sequences for RASGRP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Belongs to the RASGRP family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
  • Contains 2 EF-hand domains.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
  • Belongs to the RASGRP family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with RASGRP3: view

Function for RASGRP3 Gene

Molecular function for RASGRP3 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.

Gene Ontology (GO) - Molecular Function for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 10934204
GO:0005085 guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005096 GTPase activator activity IEA,IDA 10934204
GO:0005509 calcium ion binding NAS 10934204
genes like me logo Genes that share ontologies with RASGRP3: view
genes like me logo Genes that share phenotypes with RASGRP3: view

Animal Models for RASGRP3 Gene

MGI Knock Outs for RASGRP3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASGRP3 Gene

Localization for RASGRP3 Gene

Subcellular locations from

Jensen Localization Image for RASGRP3 Gene COMPARTMENTS Subcellular localization image for RASGRP3 gene
Compartment Confidence
plasma membrane 5
cytosol 2
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10934204
GO:0032045 guanyl-nucleotide exchange factor complex IEA --
genes like me logo Genes that share ontologies with RASGRP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASGRP3 Gene

Pathways & Interactions for RASGRP3 Gene

SuperPathways for RASGRP3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling events of B Cell Receptor (BCR)
3 B cell receptor signaling pathway (KEGG)
4 Ras signaling pathway
5 Developmental Biology
genes like me logo Genes that share pathways with RASGRP3: view

SIGNOR curated interactions for RASGRP3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007264 small GTPase mediated signal transduction IEA,TAS 10934204
GO:0007265 Ras protein signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043087 regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RASGRP3: view

Drugs & Compounds for RASGRP3 Gene

(3) Drugs for RASGRP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for RASGRP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with RASGRP3: view

Transcripts for RASGRP3 Gene

Unigene Clusters for RASGRP3 Gene

RAS guanyl releasing protein 3 (calcium and DAG-regulated):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - -
SP9: -

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1: -
SP2: -
SP3: -

Relevant External Links for RASGRP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASGRP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASGRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGRP3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.7).

Protein differential expression in normal tissues from HIPED for RASGRP3 Gene

This gene is overexpressed in Heart (37.4) and Liver (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASGRP3 Gene

Protein tissue co-expression partners for RASGRP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASGRP3 Gene:


SOURCE GeneReport for Unigene cluster for RASGRP3 Gene:

genes like me logo Genes that share expression patterns with RASGRP3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RASGRP3 Gene

Orthologs for RASGRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGRP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RASGRP3 34 35
  • 99.71 (n)
(Canis familiaris)
Mammalia RASGRP3 34 35
  • 93.81 (n)
(Bos Taurus)
Mammalia RASGRP3 34 35
  • 93.47 (n)
(Mus musculus)
Mammalia Rasgrp3 34 16 35
  • 89.28 (n)
(Monodelphis domestica)
Mammalia RASGRP3 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia RASGRP3 35
  • 88 (a)
(Rattus norvegicus)
Mammalia Rasgrp3 34
  • 87.87 (n)
(Gallus gallus)
Aves RASGRP3 34 35
  • 80.49 (n)
(Anolis carolinensis)
Reptilia RASGRP3 35
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasgrp3 34
  • 75 (n)
(Danio rerio)
Actinopterygii rasgrp3 34 35
  • 70.5 (n)
(Caenorhabditis elegans)
Secernentea rgef-1 34 35
  • 50.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
Species where no ortholog for RASGRP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASGRP3 Gene

Gene Tree for RASGRP3 (if available)
Gene Tree for RASGRP3 (if available)

Paralogs for RASGRP3 Gene

Paralogs for RASGRP3 Gene

(5) SIMAP similar genes for RASGRP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RASGRP3: view

Variants for RASGRP3 Gene

Sequence variations from dbSNP and Humsavar for RASGRP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2124437 other 33,457,670(-) AATAC(A/C)CAACT intron-variant, upstream-variant-2KB
rs1015817 -- 33,448,041(+) AAACT(A/G)TGATG intron-variant
rs10166200 -- 33,497,787(+) ATTGA(A/G)TGGTT intron-variant
rs10168103 -- 33,473,129(+) aggcc(A/G)aggtg intron-variant
rs10173760 -- 33,462,930(+) CAGAA(A/G)AAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASGRP3 Gene

Variant ID Type Subtype PubMed ID
dgv1885n106 CNV deletion 24896259
dgv444n27 CNV loss 19166990
dgv6755n54 CNV loss 21841781
dgv6756n54 CNV loss 21841781
dgv684e214 CNV loss 21293372
esv2199255 CNV deletion 18987734
esv2462414 CNV deletion 19546169
esv2661374 CNV deletion 23128226
esv2719890 CNV deletion 23290073
esv2762447 CNV gain 21179565
esv28690 CNV gain+loss 19812545
esv3554711 CNV deletion 23714750
esv3583713 CNV loss 25503493
esv3590286 CNV loss 21293372
esv3590288 CNV loss 21293372
esv3590289 CNV loss 21293372
esv3590291 CNV gain 21293372
esv3590295 CNV loss 21293372
esv3891725 CNV gain 25118596
esv4426 CNV loss 18987735
nsv1072406 CNV deletion 25765185
nsv1120122 OTHER inversion 24896259
nsv1123309 CNV deletion 24896259
nsv1127719 CNV deletion 24896259
nsv433177 CNV loss 18776910
nsv435723 CNV deletion 17901297
nsv516338 CNV loss 19592680
nsv517737 CNV loss 19592680
nsv581310 CNV loss 21841781
nsv819369 CNV gain 19587683
nsv820684 CNV deletion 20802225
nsv828775 CNV loss 20364138
nsv955027 CNV deletion 24416366

Variation tolerance for RASGRP3 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASGRP3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRP3 Gene

Disorders for RASGRP3 Gene

Relevant External Links for RASGRP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RASGRP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASGRP3 Gene

Publications for RASGRP3 Gene

  1. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PMID: 10934204) Rebhun J.F. … Quilliam L.A. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population. (PMID: 20516000) He C.F. … Yang S. (Lupus 2010) 3 46 64
  5. Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. (PMID: 19421330) Yang H.C. … Pan W.H. (PLoS ONE 2009) 3 46 64

Products for RASGRP3 Gene

Sources for RASGRP3 Gene