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Aliases for RASGRP3 Gene

Aliases for RASGRP3 Gene

  • RAS Guanyl Releasing Protein 3 (Calcium And DAG-Regulated) 2 3
  • Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor III 3 4
  • Guanine Nucleotide Exchange Factor For Rap1 3 4
  • GRP3 3 4
  • Ras Guanyl-Releasing Protein 3 3
  • KIAA0846 4

External Ids for RASGRP3 Gene

Previous GeneCards Identifiers for RASGRP3 Gene

  • GC02P033619
  • GC02P033635
  • GC02P033573
  • GC02P033514
  • GC02P033395
  • GC02P033661

Summaries for RASGRP3 Gene

Entrez Gene Summary for RASGRP3 Gene

  • Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RASGRP3 Gene

RASGRP3 (RAS Guanyl Releasing Protein 3 (Calcium And DAG-Regulated)) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGRP4.

UniProtKB/Swiss-Prot for RASGRP3 Gene

  • Guanine nucleotide exchange factor (GEF) for Ras and Rap1.

Gene Wiki entry for RASGRP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRP3 Gene

Genomics for RASGRP3 Gene

Regulatory Elements for RASGRP3 Gene

Genomic Location for RASGRP3 Gene

33,436,324 bp from pter
33,564,750 bp from pter
128,427 bases
Plus strand

Genomic View for RASGRP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASGRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRP3 Gene

Proteins for RASGRP3 Gene

  • Protein details for RASGRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras guanyl-releasing protein 3
    Protein Accession:
    Secondary Accessions:
    • D6W583
    • O94931
    • Q53SD7

    Protein attributes for RASGRP3 Gene

    690 amino acids
    Molecular mass:
    78332 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74869.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASGRP3 Gene


neXtProt entry for RASGRP3 Gene

Proteomics data for RASGRP3 Gene at MOPED

Post-translational modifications for RASGRP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RASGRP3 (RasGRP3)

No data available for DME Specific Peptides for RASGRP3 Gene

Domains for RASGRP3 Gene

Gene Families for RASGRP3 Gene

  • EFHAND :EF-hand domain containing

Suggested Antigen Peptide Sequences for RASGRP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8IV61
  • Contains 2 EF-hand domains.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
  • Belongs to the RASGRP family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with RASGRP3: view

Function for RASGRP3 Gene

Molecular function for RASGRP3 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.

Gene Ontology (GO) - Molecular Function for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 10934204
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity IEA --
GO:0005096 GTPase activator activity IDA 10934204
GO:0005509 calcium ion binding NAS 10934204
genes like me logo Genes that share ontologies with RASGRP3: view

Phenotypes for RASGRP3 Gene

genes like me logo Genes that share phenotypes with RASGRP3: view

Animal Models for RASGRP3 Gene

MGI Knock Outs for RASGRP3:

Animal Model Products

CRISPR Products

miRNA for RASGRP3 Gene

miRTarBase miRNAs that target RASGRP3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASGRP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RASGRP3 Gene

Localization for RASGRP3 Gene

Subcellular locations from

Jensen Localization Image for RASGRP3 Gene COMPARTMENTS Subcellular localization image for RASGRP3 gene
Compartment Confidence
plasma membrane 5
cytosol 2
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10934204
GO:0032045 guanyl-nucleotide exchange factor complex IEA --
genes like me logo Genes that share ontologies with RASGRP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASGRP3 Gene

Pathways for RASGRP3 Gene

genes like me logo Genes that share pathways with RASGRP3: view

Gene Ontology (GO) - Biological Process for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade NAS 10934204
GO:0007264 small GTPase mediated signal transduction TAS 10934204
GO:0007265 Ras protein signal transduction IEA --
GO:0035556 intracellular signal transduction --
GO:0043087 regulation of GTPase activity --
genes like me logo Genes that share ontologies with RASGRP3: view

Compounds for RASGRP3 Gene

(846) HMDB Compounds for RASGRP3 Gene

Compound Synonyms Cas Number PubMed IDs
  • DAG(14:0/14:0)
Not Available
  • DAG(14:0/14:1)
Not Available
  • Diacylglycerol(29:0)
Not Available
  • DAG(30:0)
Not Available
  • DG(30:1)
Not Available
genes like me logo Genes that share compounds with RASGRP3: view

Transcripts for RASGRP3 Gene

Unigene Clusters for RASGRP3 Gene

RAS guanyl releasing protein 3 (calcium and DAG-regulated):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASGRP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - -
SP9: -

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1: -
SP2: -
SP3: -

Relevant External Links for RASGRP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASGRP3 Gene

mRNA expression in normal human tissues for RASGRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGRP3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.7).

Protein differential expression in normal tissues for RASGRP3 Gene

This gene is overexpressed in Heart (37.4) and Liver (31.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASGRP3 Gene

SOURCE GeneReport for Unigene cluster for RASGRP3 Gene Hs.143674

genes like me logo Genes that share expressions with RASGRP3: view

Expression partners for RASGRP3 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RASGRP3 Gene

Orthologs for RASGRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGRP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASGRP3 35
  • 93.47 (n)
  • 96.52 (a)
  • 96 (a)
(Canis familiaris)
Mammalia RASGRP3 35
  • 93.81 (n)
  • 96.52 (a)
  • 96 (a)
(Mus musculus)
Mammalia Rasgrp3 35
  • 89.28 (n)
  • 94.35 (a)
Rasgrp3 16
Rasgrp3 36
  • 94 (a)
(Pan troglodytes)
Mammalia RASGRP3 35
  • 99.71 (n)
  • 99.85 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rasgrp3 35
  • 87.87 (n)
  • 92.69 (a)
(Monodelphis domestica)
Mammalia RASGRP3 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia RASGRP3 36
  • 88 (a)
(Gallus gallus)
Aves RASGRP3 35
  • 80.49 (n)
  • 87.63 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia RASGRP3 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasgrp3 35
  • 75 (n)
  • 80.29 (a)
(Danio rerio)
Actinopterygii rasgrp3 35
  • 70.5 (n)
  • 75.85 (a)
rasgrp3 36
  • 72 (a)
(Caenorhabditis elegans)
Secernentea rgef-1 35
  • 50.19 (n)
  • 41.44 (a)
rgef-1 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for RASGRP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASGRP3 Gene

Gene Tree for RASGRP3 (if available)
Gene Tree for RASGRP3 (if available)

Paralogs for RASGRP3 Gene

Paralogs for RASGRP3 Gene

Selected SIMAP similar genes for RASGRP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RASGRP3: view

Variants for RASGRP3 Gene

Sequence variations from dbSNP and Humsavar for RASGRP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6708 -- 33,564,467(-) CATAT(C/T)ATTGC utr-variant-3-prime
rs8256 -- 33,564,001(+) ACAGA(C/G)GTGCA utr-variant-3-prime
rs583942 -- 33,435,897(-) GCTTT(A/C)AAAAC upstream-variant-2KB
rs597593 -- 33,435,144(-) ATATC(C/T)CTTCA upstream-variant-2KB
rs604788 -- 33,439,283(-) TCTAC(A/G)TCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASGRP3 Gene

Variant ID Type Subtype PubMed ID
nsv517737 CNV Loss 19592680
nsv873792 CNV Loss 21882294
nsv828775 CNV Loss 20364138
esv2661374 CNV Deletion 23128226
dgv444n27 CNV Loss 19166990
nsv433177 CNV Loss 18776910
nsv516338 CNV Loss 19592680
nsv435723 CNV Deletion 17901297
nsv820684 CNV Deletion 20802225
esv28690 CNV Gain+Loss 19812545
nsv819369 CNV Gain 19587683
esv2462414 CNV Deletion 19546169
esv2199255 CNV Deletion 18987734
esv4426 CNV Deletion 18987735
esv2719890 CNV Deletion 23290073

Relevant External Links for RASGRP3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRP3 Gene

Disorders for RASGRP3 Gene

Relevant External Links for RASGRP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RASGRP3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RASGRP3 Gene

Publications for RASGRP3 Gene

  1. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PMID: 10934204) Rebhun J.F. … Quilliam L.A. (J. Biol. Chem. 2000) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. (PMID: 12730099) Teixeira C. … Stone J.C. (Blood 2003) 3 23
  4. A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. (PMID: 15572660) Roberts D.M. … Bautch V.L. (Mol. Cell. Biol. 2004) 3 23
  5. Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. (PMID: 15657177) Zheng Y. … Stone J.C. (Blood 2005) 3 23

Products for RASGRP3 Gene

Sources for RASGRP3 Gene

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