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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RASGRP3 Gene

protein-coding GIFtS: 63
GCID: GC02P033661

RAS guanyl releasing protein 3 (calcium and DAG-regulated)

Explore 7 diseases affiliated with
RASGRP3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAS Guanyl Releasing Protein 3 (Calcium And DAG-Regulated)¹ ²
GRP3¹ ² ³
KIAA0846¹ ³
Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor III² ³
Guanine Nucleotide Exchange Factor For Rap1² ³
Ras Guanyl-Releasing Protein 3²

External Ids:	HGNC: 14545¹	Entrez Gene: 25780²	Ensembl: ENSG00000152689⁷	OMIM: 609531⁵	UniProtKB: Q8IV61³

Export aliases for RASGRP3 gene to outside databases

Previous GC identifers: GC02P033619 GC02P033635 GC02P033573 GC02P033514 GC02P033395

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RASGRP3:

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated

switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs),

such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and

are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).(supplied

by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: GRP3_HUMAN, Q8IV61

Function: Guanine nucleotide exchange factor (GEF) for Ras and Rap1

Gene Wiki entry for RASGRP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RASGRP3 gene promoter:
SRF Sox5 SRF (504 AA) STAT5A CUTL1 NF-kappaB MEF-2A SRY aMEF-2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RASGRP3 promoter sequence

Search SABiosciences Chromatin IP Primers for RASGRP3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASGRP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1-p24.1 Ensembl cytogenetic band: 2p22.3 HGNC cytogenetic band: 2p25.1-p24.1

RASGRP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASGRP3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P033661: view genomic region (about GC identifiers)

Start:	33,661,391 bp from pter	End:	33,789,817 bp from pter
Size:	128,427 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GRP3_HUMAN, Q8IV61 (See protein sequence)

Recommended Name: Ras guanyl-releasing protein 3

Size: 690 amino acids; 78332 Da

Sequence caution: Sequence=BAA74869.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: O94931 Q53SD7

Explore the universe of human proteins at neXtProt for RASGRP3: NX_Q8IV61

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IV61

RASGRP3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001132960.1 NP_056191.1 NP_733772.1

ENSEMBL proteins:

ENSP00000385886 ENSP00000393866 ENSP00000384192 ENSP00000405648 ENSP00000401974

ENSP00000400602 ENSP00000388139 ENSP00000383917 ENSP00000409593

Reactome Protein details: Q8IV61
Human Recombinant Protein Products:

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	Uscn Proteins for RASGRP3

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	10934204
GO:0032045	guanyl-nucleotide exchange factor complex	IEA	--

RASGRP3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RASGRP3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RASGRP3 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR008937 Ras_GEF

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR020454 DAG/PE-bd

IPR023578 Ras_GEF_dom

Graphical View of Domain Structure for InterPro Entry Q8IV61

ProtoNet protein and cluster: Q8IV61

1 Blocks protein family: IPB001895 Guanine-nucleotide dissociation stimulator CDC25

UniProtKB/Swiss-Prot: GRP3_HUMAN, Q8IV61

Similarity: Belongs to the RASGRP family

Similarity: Contains 2 EF-hand domains

Similarity: Contains 1 N-terminal Ras-GEF domain

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

Similarity: Contains 1 Ras-GEF domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GRP3_HUMAN, Q8IV61

Function: Guanine nucleotide exchange factor (GEF) for Ras and Rap1

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASGRP3
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RASGRP3 (see all 15):
		hsa-miR-30c hsa-miR-3163 hsa-miR-4324 hsa-miR-30d hsa-miR-340 hsa-miR-373* hsa-miR-30a hsa-miR-544b

		SwitchGear 3'UTR luciferase reporter plasmid: RASGRP3 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGRP3

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	TAS	10934204
GO:0005085	guanyl-nucleotide exchange factor activity	TAS	--
GO:0005088	Ras guanyl-nucleotide exchange factor activity	IEA	--
GO:0005509	calcium ion binding	NAS	10934204
GO:0017016	Ras GTPase binding	IEA	--

RASGRP3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Rasgrp3^tm1Jstn for RASGRP3
     3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rasgrp3):

hematopoietic system

immune system

normal

RASGRP3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling TC21 regulation pathway

	G-protein signaling TC21 regulation pathway	1.00			G-protein signaling_M-RAS regulation pathway	0.71
	G-protein signaling_TC21 regulation pathway	1.00			G-protein signaling M-RAS regulation pathway	0.71

G-protein signaling K-RAS regulation pathway

	G-protein signaling K-RAS regulation pathway	1.00			G-protein signaling H-RAS regulation pathway	0.27
	G-protein signaling_H-RAS regulation pathway	0.27

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Signaling by the B Cell Receptor (BCR)

Signaling by the B Cell Receptor (BCR)

1.00

Downstream Signaling Events Of B Cell Receptor (BCR)

0.81

G-protein signaling Rap1A regulation pathway

G-protein signaling Rap1A regulation pathway

1.00

G-protein signaling_Rap1A regulation pathway

0.88

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 EMD Millipore Pathways for RASGRP3 (see all 6)

	G-protein signaling K-RAS regulation pathway
	G-protein signaling N-RAS regulation pathway
	G-protein signaling M-RAS regulation pathway
	G-protein signaling TC21 regulation pathway
	G-protein signaling Rap1A regulation pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RASGRP3

ITK and TCR Signaling

2 Cell Signaling Technology (CST) Pathways for RASGRP3

	MAP Kinase Signaling
	Cytoskeletal Signaling

4 GeneGo (Thomson Reuters) Pathways for RASGRP3

	G-protein signaling H-RAS regulation pathway
	G-protein signaling TC21 regulation pathway
	G-protein signaling M-RAS regulation pathway
	G-protein signaling Rap1A regulation pathway

2 BioSystems Pathways for RASGRP3

	Integrated Breast Cancer Pathway
	B Cell Receptor Signaling Pathway

5/6 Reactome Pathways for RASGRP3 (see all 6)

	Activation of RAS in B Cells
	Activation of RasGRP1 and RasGRP3 by Recruitment to the Membrane and Phosphorylation
	Downstream Signaling Events Of B Cell Receptor (BCR)
	Adaptive Immune System
	Immune System

2 Kegg Pathways (Kegg details for RASGRP3):

	MAPK signaling pathway
	B cell receptor signaling pathway

RASGRP3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RASGRP3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/48 Interacting proteins for RASGRP3 (Q8IV61³ ENSP00000384192⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 48)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKCB	P05771³, ENSP00000305355⁴	I2D: score=3 STRING: ENSP00000305355
PRKCD	Q05655³, ENSP00000331602⁴	I2D: score=3 STRING: ENSP00000331602
PRKCQ	Q04759³, ENSP00000263125⁴	I2D: score=2 STRING: ENSP00000263125
PRKACA	P17612³, ENSP00000309591⁴	I2D: score=1 STRING: ENSP00000309591
PIK3CA	P42336³, ENSP00000263967⁴	I2D: score=1 STRING: ENSP00000263967

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	NAS	10934204
GO:0007264	small GTPase mediated signal transduction	TAS	10934204
GO:0007265	Ras protein signal transduction	IEA	--
GO:0032854	positive regulation of Rap GTPase activity	IDA	10934204
GO:0043087	regulation of GTPase activity	--	--

RASGRP3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RASGRP3

10/846 HMDB Compounds for RASGRP3 (see all 846) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--
DG(14:0/18:2(9Z,12Z)/0:0)	DAG(14:0/18:2n6) (see all 15)	--	--
DG(14:0/18:3(6Z,9Z,12Z)/0:0)	Diacylglycerol(14:0/18:3n6) (see all 16)	--	--

Search CenterWatch for drugs/clinical trials and news about RASGRP3 / GRP3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RASGRP3 gene (3 alternative transcripts):

NM_001139488.1 NM_015376.2 NM_170672.2

Unigene Cluster for RASGRP3:

RAS guanyl releasing protein 3 (calcium and DAG-regulated)

Hs.143674 [show with all ESTs]

Unigene Representative Sequence: NM_001139488

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000402538(uc002rox.3) ENST00000484909(uc002row.1) ENST00000497723

ENST00000479528 ENST00000437184 ENST00000403687(uc010ync.2) ENST00000482857

ENST00000442390 ENST00000425210 ENST00000444784 ENST00000423159 ENST00000494927

ENST00000407811(uc002roy.3) ENST00000477927 ENST00000490150 ENST00000419772

ENST00000468856 ENST00000482731

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		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RASGRP3 (see all 15):
		hsa-miR-30c hsa-miR-3163 hsa-miR-4324 hsa-miR-30d hsa-miR-340 hsa-miR-373* hsa-miR-30a hsa-miR-544b

		SwitchGear 3'UTR luciferase reporter plasmid: RASGRP3 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASGRP3

Additional cDNA sequence:

AB020653.1 AK124316.1 AK125551.1 AK292983.1 BC027849.1 BX647990.1

14 DOTS entries:

DT.101956867 DT.99932307 DT.456370 DT.70105047 DT.100016628 DT.99938872 DT.86845183 DT.86852875

DT.121005150 DT.40225859 DT.75173374 DT.91707627 DT.91707649 DT.91855304

24/124 AceView cDNA sequences (see all 124):

BQ049851 AI803282 NM_170672 AW188004 W01365 AI521153 AW504122 AK125551

AK124316 AI361501 AI203954 AW452373 AI221645 AI868726 AA911204 AW005810

BC027849 BI770202 CB529768 CF552118 AI125433 BF514188 AI708531 AI708223

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP3 (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c	·	11d	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19a	·
SP1:							-		-		-		-		-		-						-								-		-
SP2:															-		-						-								-		-
SP3:																															-		-
SP4:									-		-		-		-		-						-								-		-
SP5:																	-		-				-								-		-

ExUns:	19b	^	20	^	21	^	22	^	23	^	24	^	25a	·	25b	·	25c
SP1:	-
SP2:	-
SP3:	-
SP4:
SP5:

ECgene alternative splicing isoforms for RASGRP3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RASGRP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAACAACAT

About this image

RASGRP3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Fetal cardiomyocytes (20 weeks) (Primary Cell)

Heart, Myocardium

See RASGRP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RASGRP3

SOURCE GeneReport for Unigene cluster: Hs.143674

SABiosciences Custom PCR Arrays for RASGRP3

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASGRP3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGRP3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RASGRP3 gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RASGRP3¹	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	80.49(n) 87.63(a)		421460 NM_001006401.1 NP_001006401.1
lizard (Anolis carolinensis)	Reptilia	RASGRP3⁶	--	85(a)	1 ↔ 1	1(231362325-231394949)
zebrafish (Danio rerio)	Actinopterygii	rasgrp3¹	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	70.45(n) 75.81(a)		563441 NM_001110464.1 NP_001103934.1
worm (Caenorhabditis elegans)	Secernentea	rgef-1¹	Protein RGEF-1	50.19(n) 41.44(a)		179344 NM_073068.3 NP_505469.3

ENSEMBL Gene Tree for RASGRP3 (if available)
TreeFam Gene Tree for RASGRP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RASGRP3 gene

RASGRP4² RASGRP1² RASGRP2²

5 SIMAP similar genes for RASGRP3 using alignment to 8 protein entries: GRP3_HUMAN (see all proteins):

RASGRP1 RASGRP2 PRKD1 DKFZp781H1715 RASGRP4

RASGRP3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186884197^1,2		--	33659498(+)	`CAAAAC/GAATAA`	1	--	us2k¹		0	--	--	--	--
rs138792722^1,2		--	33659676(+)	`CCGGGC/TGTGGT`	1	--	us2k¹		0	--	--	--	--
rs683473^1,2		--	33659688(-)	`caggcA/Gtgtgc`	1	--	us2k¹		1		NA	2
rs609994^1,2		--	33659748(-)	`acctcC/Tgcctc`	1	--	us2k¹		2		NA CSA	4
rs115345784^1,2	F,	--	33659841(+)	`TGGGGG/TCTGGG`	1	--	us2k¹		1		WA	118
rs190595214^1,2		--	33659874(+)	`TTCATA/TTCTTC`	1	--	us2k¹		0	--	--	--	--
rs183484945^1,2		--	33659955(+)	`AATTTA/GTCTAT`	1	--	us2k¹		0	--	--	--	--
rs148570097^1,2		--	33660150(+)	`AAAAGC/TATATA`	1	--	us2k¹		0	--	--	--	--
rs188819803^1,2		--	33660179(+)	`ACATTA/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs597593^1,2	C,F,A,H,	--	33660211(-)	`ATATCT/CCTTCA`	1	--	us2k¹ tfbs³		21		NS EA NA WA CSA	2348

HapMap Linkage Disequilibrium report for RASGRP3 (33661391 - 33789817 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for RASGRP3
9 CNVs: 58984 53254 50463 50466 50462 50465 67403 97808 23006
4 Indels: 40319 45994 42665 50464
Human Gene Mutation Database (HGMD): RASGRP3

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RASGRP3 for disorders           About GeneDecksing

OMIM gene information: 609531    OMIM disorders: --

7 diseases for RASGRP3:    About MalaCards

systemic lupus erythematosus lupus erythematosus prostate cancer hypertension

prostatitis melanoma neuronitis

Human Genome Epidemiology (HuGE) Navigator: RASGRP3 (4 documents)

Export disorders for RASGRP3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RASGRP3 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with RASGRP3)

Utopia: connect your pdf to the dynamic
world of online information

Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PubMed id 10934204)^{1, 2, 3, 9} Rebhun J.F.... Quilliam L.A. (2000)
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2, 3} Nagase T....Ohara O. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. (PubMed id 15572660)^{1, 9} Roberts D.M....Bautch V.L. (2004)
Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. (PubMed id 12730099)^{1, 9} Teixeira C....Stone J.C. (2003)
Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. (PubMed id 15657177)^{1, 9} Zheng Y.... Stone J.C. (2005)
RasGRP3, a Ras activator, contributes to signaling an d the tumorigenic phenotype in human melanoma. (PubMed id 21602881)¹ Yang D....Blumberg P.M. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associate d with clinical features of systemic lupus erythematosus in a Chinese Han popul ation. (PubMed id 20516000)¹ He C.F....Yang S. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25780	HGNC: 14545	AceView: RASGRP3	Ensembl:ENSG00000152689	euGenes: HUgn25780
ECgene: RASGRP3	Kegg: 25780	H-InvDB: RASGRP3

(According to HUGE)
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HUGE: KIAA0846

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RASGRP3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RASGRP3 gene
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Patent Information for RASGRP3 gene:
Search GeneIP for patents involving RASGRP3

GeneCards and IP:
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RAS guanyl releasing protein 3 (calcium and DAG-regulated)

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RAS guanyl releasing protein 3 (calcium and DAG-regulated)

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