RASGRP2 Gene
protein-coding GIFtS: 62
GCID: GC11M064494
|
|
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
| |
Aliases
for RASGRP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAS Guanyl Releasing Protein 2 (Calcium And DAG-Regulated)1 2 | | Calcium And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor I2 | | CDC25L2 3 5 | | Guanine Exchange Factor MCG72 | | CALDAG-GEFI1 2 | | RAS Guanyl Nucleotide-Releasing Protein 22 | | Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor I2 3 | | RAS Guanyl-Releasing Protein 22 | | Cdc25-Like Protein2 3 | | CalDAG-GEFI3 | | F25B3.3 Kinase-Like Protein2 3 | | MCG73 | | HCDC25L1 | | |
Export aliases for RASGRP2 gene to outside databasesPrevious GC identifers: GC11M067010 GC11M066175 GC11M064744 GC11M064270 GC11M064271 GC11M064250 GC11M060821 |
Summaries
for RASGRP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RASGRP2:
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEFdomain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-bindingdomain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of thisprotein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding thesame protein have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GRP2_HUMAN, Q7LDG7Function: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through theexchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS.Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-outintegrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway
Gene Wiki entry for RASGRP2
|
Genomic Views
for RASGRP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RASGRP2 gene promoter:
CREB GATA-2 YY1 c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RASGRP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASGRP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13RASGRP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M064494: view genomic region
(about GC identifiers)
Start:
|
64,494,383 bp from pter |
End:
|
64,512,928 bp from pter |
Size:
|
18,546 bases |
Orientation:
|
minus strand |
|
Proteins
for RASGRP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GRP2_HUMAN, Q7LDG7 (See
protein sequence)Recommended Name: RAS guanyl-releasing protein 2 Size: 609 amino acids; 69248 Da
Subunit: Forms a signaling complex with RAP1 and BRAF (By similarity). Interacts with RAP1. Interacts with F-actin
Subcellular location: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, synapse,synaptosome (Potential). Cell projection, ruffle membrane; Peripheral membrane protein (Potential). Note=Found both inthe cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembraneareas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatalneurons (By similarity)
Developmental stage: Expressed in fetal brain, lung, liver and kidney
Caution: Defects in RASGRP2 were initially thought (PubMed:17576779) to be the cause of leukocyte adhesion deficiencytype 3 (LAD3), a syndrome characterized by recurrent bacterial infections and major bleeding disorders. However, itwas later shown (PubMed:19064721, PubMed:19234463 and PubMed:19234460) that it is not the case and that LAD3 is causedby defects in FERMT3 gene
Secondary accessions: O00538 Q9UL65Alternative splicing: 3 isoforms: Q7LDG7-1 Q7LDG7-2 Q7LDG7-3 (The corresponding protein is not undetectable)Explore the universe of human proteins at neXtProt for RASGRP2: NX_Q7LDG7
Post-translational modifications:
Isoform 2 is palmitoylated and myristoylated while isoform 11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7LDG7
RASGRP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001092140.1 NP_001092141.1 NP_722541.1
ENSEMBL proteins: ENSP00000366714 ENSP00000401510 ENSP00000377953 ENSP00000366717 ENSP00000338864 ENSP00000396029 ENSP00000399114 ENSP00000399028 ENSP00000377950 ENSP00000377949 ENSP00000366706 ENSP00000366707 ENSP00000366709 ENSP00000377951 ENSP00000366705 ENSP00000401314 ENSP00000389068 Reactome Protein details: Q7LDG7
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
RASGRP2 for ontologies About GeneDecksing
RASGRP2 Antibody Products:
Assay Products for RASGRP2: |
Protein
Domains /
Families
for RASGRP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RASGRP2 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q7LDG7ProtoNet protein and cluster: Q7LDG7 1 Blocks protein family: IPB001895 Guanine-nucleotide dissociation stimulator CDC25
UniProtKB/Swiss-Prot: GRP2_HUMAN, Q7LDG7Domain: The N-terminal Ras-GEF domain mediates association with F-actinSimilarity: Belongs to the RASGRP familySimilarity: Contains 2 EF-hand domainsSimilarity: Contains 1 N-terminal Ras-GEF domainSimilarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 Ras-GEF domain |
Function
for RASGRP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GRP2_HUMAN, Q7LDG7Function: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through theexchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS.Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-outintegrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathwayEnzyme regulation: Isoform 1 and isoform 2 are differently regulated by calcium and DAG
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASGRP2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASGRP2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): RASGRP2 (NM_001098670) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RASGRP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASGRP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGRP2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RASGRP2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Rasgrp2tm1Amg for RASGRP2
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Rasgrp2):
RASGRP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RASGRP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Platelet activation, signaling and aggregation | | | 3 | Immune System | | | 4 | G alpha (q) signalling events | | | 5 | Integrin alphaIIb beta3 signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for RASGRP2
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RASGRP2
5  GeneGo (Thomson Reuters) Pathways for RASGRP2
2  BioSystems Pathways for RASGRP2
5/14 
Reactome Pathways for RASGRP2 (see all 14)
2 
Kegg Pathways (Kegg details for RASGRP2):
RASGRP2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASGRP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/37 Interacting proteins for RASGRP2 (Q7LDG72, 3 ENSP000003388644) via UniProtKB, MINT, STRING, and/or I2D (see all 37)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
RASGRP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for RASGRP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RASGRP2 for compounds About GeneDecksing
 Browse Tocris compounds for RASGRP2
10/845 HMDB Compounds for RASGRP2 (see all 845) About this table
1 Novoseek chemical compound relationship for RASGRP2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| calcium |
23.2 |
5 |
10918068 (2), 11292831 (1), 18256319 (1) |
Search CenterWatch for drugs/clinical trials and news about RASGRP2 / GRP2
|
Transcripts
for RASGRP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RASGRP2 gene (4 alternative transcripts): NM_001098670.1 NM_001098671.1 NM_153819.1 NM_005825.2 Unigene Cluster for RASGRP2: RAS guanyl releasing protein 2 (calcium and DAG-regulated) Hs.99491 [show with all ESTs]Unigene Representative Sequence: AK09288218/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23): ENST00000464324(uc001oat.3) ENST00000377494(uc001oau.3) ENST00000421556
ENST00000394432(uc009ypu.3) ENST00000377497(uc009ypv.3) ENST00000354024(uc009ypw.3)
ENST00000488071 ENST00000494001 ENST00000497441 ENST00000465852 ENST00000445445
ENST00000431822 ENST00000441258 ENST00000394429 ENST00000394428 ENST00000377486
ENST00000377487 ENST00000377489
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASGRP2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASGRP2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): RASGRP2 (NM_001098670) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RASGRP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASGRP2 |
Additional cDNA sequence: AF043722.1 AF043723.1 AF081194.1 AK092852.1 AK092882.1 AK122694.1 AK124023.1 AK314637.1 BC110306.1 BC117151.1 U78170.1 Y12336.1 16 DOTS entries: DT.111459 DT.100649846 DT.95151432 DT.95341309 DT.100775666 DT.92419011 DT.100805296 DT.99928997 DT.102836316 DT.100649847 DT.100865652 DT.120740712 DT.120740717 DT.86855259 DT.91687359 DT.95094000 24/114 AceView cDNA sequences (see all 114): AV655659 BX345214 BI031621 BX391977 BX418854 AI660707 AA721671 BG980607 BQ002266 BX282609 BG060104 AA548867 NM_153819 Y12336 AF043723 BI518478 AK092882 NM_005825 BX436968 CD244914 AW197963 CR601768 AF043722 AK122694
GeneLoc Exon Structure
5/23 Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP2 (see all 23) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | - | | - | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | - | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | - | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RASGRP2
|
Expression
for RASGRP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RASGRP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCTGAGGG
About this image
See RASGRP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RASGRP2
SOURCE GeneReport for Unigene cluster: Hs.99491
UniProtKB/Swiss-Prot: GRP2_HUMAN, Q7LDG7Tissue specificity: Detected in platelets, neutrophils and T lymphocytes (at protein level). Expressed in brain whereit is enriched in the striatum. Also expressed in the hematopoietic system. Detected in heart, brain, lung, placenta,liver, skeletal muscle and kidney
SABiosciences Custom PCR Arrays for RASGRP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASGRP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RASGRP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASGRP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASGRP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGRP2 |
Orthologs
for RASGRP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RASGRP2 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
RASGRP26 |
-- |
74(a) |
1 ↔ 1 |
GL344934.1(2074-8486) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC527982 |
similar to RAS guanyl releasing protein 2 (calcium more |
74.23(n) |
|
BC044323.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5570631 |
RAS guanyl-releasing protein 2-like |
65.28(n)
61.81(a) |
|
557063 XM_680043.3 XP_685135.3 |
worm
(Caenorhabditis elegans) |
Secernentea |
F25B3.33 |
phorbol ester and DAG binding domain |
34(a) |
|
V(9559306-9564198) -- |
ENSEMBL Gene Tree for RASGRP2 (if available)
TreeFam Gene Tree for RASGRP2 (if available) |
Paralogs
for RASGRP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RASGRP2 gene
- RASGRP42 RASGRP12 RASGRP32
3 SIMAP similar genes for RASGRP2 using alignment to 12 protein entries: GRP2_HUMAN (see all proteins):RASGRP3 RASGRP1 RASGRP4
RASGRP2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RASGRP2
PGOHUM00000245943
|
Genomic Variants
for RASGRP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RASGRP2 (64494383 - 64512928 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RASGRP2
3 CNVs: 4753 53146 9667
Human Gene Mutation Database (HGMD): RASGRP2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RASGRP2 |
|
Disorders
/ Diseases
for RASGRP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RASGRP2 for disorders About GeneDecksing
OMIM gene information: 605577
OMIM disorders: --
7  diseases for RASGRP2: About MalaCardsleukocyte adhesion deficiency, type iii myeloid leukemia thrombocytopenia leukemia
neuronitis bleeding disorder gout
1 disease from the University of Copenhagen DISEASES database for RASGRP2:Leukocyte adhesion deficiency Export disorders for RASGRP2 gene to outside databases
|
Publications
for RASGRP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RASGRP2 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with RASGRP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. (PubMed id 9789079)1, 2, 3 Kawasaki H.... Graybiel A.M. (1998)
- Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor. (PubMed id 10918068)1, 2, 9 Clyde-Smith J.... Hancock J.F. (2000)
- Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1. (PubMed id 14702343)1, 2 Katagiri K.... Kinashi T. (2004)
- The germinal centre kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. (PubMed id 9341881)1, 2 Kedra D.... Dumanski J. (1997)
- A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2. (PubMed id 11292831)1, 9 Guo F.F....Saffen D. (2001)
- A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets. (PubMed id 17576779)2, 9 Pasvolsky R.... Alon R. (2007)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genome-wide association study for serum urate concent rations and gout among African Americans identifies genomic risk loci and a nov el URAT1 loss-of-function allele. (PubMed id 21768215)1 Tin A....KAPttgen A. (2011)
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External Searches for RASGRP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RASGRP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RASGRP2 gene
(According to HUGE)
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Specialized Databases showing RASGRP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for RASGRP2 | Pharmacogenomics, SNPs, Pathways | | RASGRP2base | http://bioinf.uta.fi/RASGRP2base/ |
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About This Section
| Patent Information for RASGRP2 gene:
Search GeneIP for patents involving RASGRP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RASGRP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RASGRP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RASGRP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASGRP2 | | | OriGene Protein Over-expression Lysate for RASGRP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RASGRP2 | | OriGene 3'-UTR Clone for RASGRP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASGRP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASGRP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RASGRP2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RASGRP2 | | OriGene Custom Protein Services for RASGRP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RASGRP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RASGRP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASGRP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASGRP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASGRP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASGRP2 |
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| | | | Search Tocris compounds for RASGRP2 |
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 | | | RASGRP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGRP2 |
|  |  |  | | | | Search ThermoFisher Antibodies for RASGRP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASGRP2 |
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