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Aliases for RASGRP2 Gene

Aliases for RASGRP2 Gene

  • RAS Guanyl Releasing Protein 2 (Calcium And DAG-Regulated) 2 3
  • CDC25L 3 4 6
  • Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor I 3 4
  • F25B3.3 Kinase-Like Protein 3 4
  • Cdc25-Like Protein 3 4
  • CALDAG-GEFI 3 4
  • HCDC25L 3 4
  • Calcium And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor I 3
  • RAS Guanyl Nucleotide-Releasing Protein 2 3
  • RAS Guanyl-Releasing Protein 2 3
  • Guanine Exchange Factor MCG7 3
  • MCG7 4

External Ids for RASGRP2 Gene

Summaries for RASGRP2 Gene

Entrez Gene Summary for RASGRP2 Gene

  • The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASGRP2 Gene

RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium And DAG-Regulated)) is a Protein Coding gene. Diseases associated with RASGRP2 include bleeding disorder, platelet-type, 18 and leukocyte adhesion deficiency. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include calcium ion binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGRP3.

UniProtKB/Swiss-Prot for RASGRP2 Gene

  • Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.

Gene Wiki entry for RASGRP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRP2 Gene

Genomics for RASGRP2 Gene

Genomic Location for RASGRP2 Gene

Start:
64,726,911 bp from pter
End:
64,745,456 bp from pter
Size:
18,546 bases
Orientation:
Minus strand

Genomic View for RASGRP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASGRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRP2 Gene

Regulatory Elements for RASGRP2 Gene

Proteins for RASGRP2 Gene

  • Protein details for RASGRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LDG7-GRP2_HUMAN
    Recommended name:
    RAS guanyl-releasing protein 2
    Protein Accession:
    Q7LDG7
    Secondary Accessions:
    • A6NDC7
    • O00538
    • Q9UL65

    Protein attributes for RASGRP2 Gene

    Size:
    609 amino acids
    Molecular mass:
    69248 Da
    Quaternary structure:
    • Forms a signaling complex with RAP1 and BRAF (By similarity). Interacts with RAP1. Interacts with F-actin.

    Three dimensional structures from OCA and Proteopedia for RASGRP2 Gene

    Alternative splice isoforms for RASGRP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASGRP2 Gene

Proteomics data for RASGRP2 Gene at MOPED

Post-translational modifications for RASGRP2 Gene

No data available for DME Specific Peptides for RASGRP2 Gene

Domains for RASGRP2 Gene

Gene Families for RASGRP2 Gene

HGNC:
  • EFHAND :EF-hand domain containing

UniProtKB/Swiss-Prot:

GRP2_HUMAN
Domain:
  • The N-terminal Ras-GEF domain mediates association with F-actin:
    • Q7LDG7
  • Contains 2 EF-hand domains.:
    • Q7LDG7
  • Contains 1 N-terminal Ras-GEF domain.:
    • Q7LDG7
  • Contains 1 Ras-GEF domain.:
    • Q7LDG7
Family:
  • Belongs to the RASGRP family.:
    • Q7LDG7
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.:
    • Q7LDG7
genes like me logo Genes that share domains with RASGRP2: view

Function for RASGRP2 Gene

Molecular function for RASGRP2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Isoform 1 and isoform 2 are differently regulated by calcium and DAG.
UniProtKB/Swiss-Prot Function: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.

Gene Ontology (GO) - Molecular Function for RASGRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity TAS 9789079
GO:0005509 calcium ion binding TAS 9789079
GO:0008289 lipid binding TAS 9789079
GO:0019992 diacylglycerol binding NAS 10918068
genes like me logo Genes that share ontologies with RASGRP2: view

Phenotypes for RASGRP2 Gene

genes like me logo Genes that share phenotypes with RASGRP2: view

Animal Models for RASGRP2 Gene

MGI Knock Outs for RASGRP2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RASGRP2 Gene

Localization for RASGRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASGRP2 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell projection, ruffle membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembrane areas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatal neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASGRP2 Gene COMPARTMENTS Subcellular localization image for RASGRP2 gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RASGRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 10918068
GO:0030054 cell junction IEA --
GO:0032587 ruffle membrane IEA --
genes like me logo Genes that share ontologies with RASGRP2: view

Pathways for RASGRP2 Gene

genes like me logo Genes that share pathways with RASGRP2: view

Gene Ontology (GO) - Biological Process for RASGRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 10918068
GO:0007165 signal transduction TAS 9789079
GO:0007264 small GTPase mediated signal transduction --
GO:0007265 Ras protein signal transduction NAS 10918068
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with RASGRP2: view

Compounds for RASGRP2 Gene

(845) HMDB Compounds for RASGRP2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available

(1) Novoseek inferred chemical compound relationships for RASGRP2 Gene

Compound -log(P) Hits PubMed IDs
calcium 23.2 4
genes like me logo Genes that share compounds with RASGRP2: view

Transcripts for RASGRP2 Gene

Unigene Clusters for RASGRP2 Gene

RAS guanyl releasing protein 2 (calcium and DAG-regulated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - -
SP14: - - - - -
SP15: - -
SP16:
SP17: - -
SP18: - - - - - - - - -
SP19:
SP20:
SP21: - -
SP22:
SP23: - - - - - - - - -

ExUns: 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - -
SP16: -
SP17:
SP18:
SP19:
SP20: -
SP21:
SP22:
SP23:

Relevant External Links for RASGRP2 Gene

GeneLoc Exon Structure for
RASGRP2
ECgene alternative splicing isoforms for
RASGRP2

Expression for RASGRP2 Gene

mRNA expression in normal human tissues for RASGRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGRP2 Gene

This gene is overexpressed in Whole Blood (12.3) and Spleen (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASGRP2 Gene

SOURCE GeneReport for Unigene cluster for RASGRP2 Gene Hs.99491

mRNA Expression by UniProt/SwissProt for RASGRP2 Gene

Q7LDG7-GRP2_HUMAN
Tissue specificity: Detected in platelets, neutrophils and T lymphocytes (at protein level). Expressed in brain where it is enriched in the striatum. Also expressed in the hematopoietic system. Detected in heart, brain, lung, placenta, liver, skeletal muscle and kidney.
genes like me logo Genes that share expressions with RASGRP2: view

Orthologs for RASGRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASGRP2 36
  • 99.51 (n)
  • 99.67 (a)
RASGRP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASGRP2 36
  • 92 (n)
  • 96.87 (a)
RASGRP2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASGRP2 36
  • 92.02 (n)
  • 97.85 (a)
RASGRP2 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasgrp2 36
  • 88.87 (n)
  • 96.38 (a)
Rasgrp2 16
Rasgrp2 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASGRP2 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasgrp2 36
  • 88.49 (n)
  • 97.04 (a)
lizard
(Anolis carolinensis)
Reptilia RASGRP2 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52798 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733706 36
  • 63.72 (n)
  • 65.2 (a)
zebrafish
(Danio rerio)
Actinopterygii rasgrp2 36
  • 64.35 (n)
  • 60.85 (a)
rasgrp2 37
  • 60 (a)
OneToMany
RASGRP2 (2 of 2) 37
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgef-1 37
  • 31 (a)
OneToMany
F25B3.3 38
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
Species with no ortholog for RASGRP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASGRP2 Gene

ENSEMBL:
Gene Tree for RASGRP2 (if available)
TreeFam:
Gene Tree for RASGRP2 (if available)

Paralogs for RASGRP2 Gene

Paralogs for RASGRP2 Gene

Pseudogenes.org Pseudogenes for RASGRP2 Gene

genes like me logo Genes that share paralogs with RASGRP2: view

Variants for RASGRP2 Gene

Sequence variations from dbSNP and Humsavar for RASGRP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3725 -- 64,727,009(+) GCCCT(C/T)AGCTG utr-variant-3-prime
rs494128 -- 64,731,153(+) agttc(A/C/G/T)agacc intron-variant
rs534221 -- 64,729,689(+) CAAAA(C/T)AGTAA intron-variant
rs536017 -- 64,736,288(+) GCTAA(G/T)AATCC intron-variant
rs546323 -- 64,740,327(-) GGGGT(C/G)GGGGG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RASGRP2 Gene

Variant ID Type Subtype PubMed ID
nsv897694 CNV Loss 21882294
nsv818842 CNV Gain 17921354
nsv528506 CNV Loss 19592680
dgv1171n71 CNV Loss 21882294
dgv1172n71 CNV Loss 21882294
nsv359 CNV Loss 18451855
dgv153n27 CNV Loss 19166990
nsv832189 CNV Loss 17160897
nsv825946 CNV Gain 20364138
nsv897701 CNV Loss 21882294

Relevant External Links for RASGRP2 Gene

HapMap Linkage Disequilibrium report
RASGRP2
Human Gene Mutation Database (HGMD)
RASGRP2

Disorders for RASGRP2 Gene

UniProtKB/Swiss-Prot

GRP2_HUMAN
  • Bleeding disorder, platelet-type 18 (BDPLT18) [MIM:615888]: A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. {ECO:0000269 PubMed:24958846}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RASGRP2 Gene

Relevant External Links for RASGRP2

Genetic Association Database (GAD)
RASGRP2
genes like me logo Genes that share disorders with RASGRP2: view

Publications for RASGRP2 Gene

  1. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. (PMID: 9789079) Kawasaki H. … Graybiel A.M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  2. Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor. (PMID: 10918068) Clyde-Smith J. … Hancock J.F. (J. Biol. Chem. 2000) 3 4 23
  3. A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2. (PMID: 11292831) Guo F.F. … Saffen D. (J. Biol. Chem. 2001) 3 23
  4. The germinal centre kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. (PMID: 9341881) Kedra D. … Dumanski J. (Hum. Genet. 1997) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for RASGRP2 Gene

Sources for RASGRP2 Gene

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