Aliases for RASGRP1 Gene
- RAS Guanyl Releasing Protein 1 2 3 5
- Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor II 2 3
- Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor II 3 4
- RAS Guanyl Releasing Protein 1 (Calcium And DAG-Regulated) 2 3
- CALDAG-GEFII 3 4
- RASGRP 3 4
- Guanine Nucleotide Exchange Factor, Calcium- And DAG-Regulated, Rap1A 3
- RAS Guanyl Nucleotide-Releasing Protein 1 3
External Ids for RASGRP1 Gene
Previous GeneCards Identifiers for RASGRP1 Gene
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
GeneCards Summary for RASGRP1 Gene
RASGRP1 (RAS Guanyl Releasing Protein 1) is a Protein Coding gene. Diseases associated with RASGRP1 include Lupus Erythematosus and Spastic Paraplegia 11, Autosomal Recessive. Among its related pathways are RET signaling and Rap1 signalling. GO annotations related to this gene include calcium ion binding and lipid binding. An important paralog of this gene is RASGRP3.
UniProtKB/Swiss-Prot for RASGRP1 Gene
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).