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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RASGRP1 Gene

protein-coding GIFtS: 66
GCID: GC15M038780

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

Explore 14 diseases affiliated with
RASGRP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAS Guanyl Releasing Protein 1 (Calcium And DAG-Regulated)¹ ²		Guanine Nucleotide Exchange Factor, Calcium- And DAG-Regulated, Rap1A²
RASGRP¹ ² ³		HRasGRP1¹
CalDAG-GEFII¹ ³		Ras Activator RasGRP²
Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor II² ³		RAS Guanyl Nucleotide-Releasing Protein 1²
CALDAG-GEFI²		RAS Guanyl-Releasing Protein 1²
CALDAG-GEFII²		Ras Guanyl-Releasing Protein³
V²

External Ids:	HGNC: 9878¹	Entrez Gene: 10125²	Ensembl: ENSG00000172575⁷	OMIM: 603962⁵	UniProtKB: O95267³

Export aliases for RASGRP1 gene to outside databases

Previous GC identifers: GC15M034123 GC15M031676 GC15M036359 GC15M036496 GC15M036567 GC15M015624

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RASGRP1:

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide

exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically

activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates

T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding

different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause

of susceptibility to systemic lupus erythematosus (SLE). (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GRP1_HUMAN, O95267

Function: Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through

the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes

antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and

differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating

allergic responses. May also function in other cell types differentiation

Gene Wiki entry for RASGRP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RASGRP1 gene promoter:
E2F-4 E2F-3a E2F-5 FOXO3 E2F-2 C/EBPalpha PPAR-gamma1 E2F E2F-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RASGRP1 promoter sequence

Search SABiosciences Chromatin IP Primers for RASGRP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASGRP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q15

RASGRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASGRP1 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M038780: view genomic region (about GC identifiers)

Start:	38,780,302 bp from pter	End:	38,857,776 bp from pter
Size:	77,475 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GRP1_HUMAN, O95267 (See protein sequence)

Recommended Name: RAS guanyl-releasing protein 1

Size: 797 amino acids; 90402 Da

Subunit: Forms a signaling complex with DGKZ and HRAS. Interacts with F-actin. Interacts with SKAP1

Subcellular location: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane;

Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the

cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent.

Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but

not to axons of hippocampal pyramidal cells (By similarity)

Developmental stage: Expressed in fetal brain and kidney

Sequence caution: Sequence=AAH67298.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence;

Secondary accessions: Q56CZ0 Q58G75 Q59HB1 Q5I3A8 Q6GV31 Q6NX39 Q7LDG6 Q9UI94 Q9UNN9

Alternative splicing: 5 isoforms: O95267-1 O95267-2 O95267-3 O95267-4 O95267-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RASGRP1: NX_O95267

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95267

RASGRP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001122074.1 NP_005730.2

ENSEMBL proteins:

ENSP00000310244 ENSP00000453583 ENSP00000452859 ENSP00000388540 ENSP00000452721

ENSP00000413105 ENSP00000454164 ENSP00000453729 ENSP00000454053 ENSP00000453905

ENSP00000454005 ENSP00000452892 ENSP00000444762

Reactome Protein details: O95267
Human Recombinant Protein Products:

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	Uscn Proteins for RASGRP1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005622	intracellular	--	--
GO:0005624	membrane fraction	--	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005829	cytosol	TAS	--

RASGRP1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RASGRP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RASGRP1 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR008937 Ras_GEF

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR020454 DAG/PE-bd

IPR023578 Ras_GEF_dom

Graphical View of Domain Structure for InterPro Entry O95267

ProtoNet protein and cluster: O95267

1 Blocks protein family: IPB001895 Guanine-nucleotide dissociation stimulator CDC25

UniProtKB/Swiss-Prot: GRP1_HUMAN, O95267

Domain: The phorbol-ester/DAG-type zinc finger is the principal mediator of the targeting to membranes and is required

for functional activation through DAG-binding

Similarity: Belongs to the RASGRP family

Similarity: Contains 2 EF-hand domains

Similarity: Contains 1 N-terminal Ras-GEF domain

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

Similarity: Contains 1 Ras-GEF domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GRP1_HUMAN, O95267

Function: Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through

the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes

antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and

differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating

allergic responses. May also function in other cell types differentiation

Enzyme regulation: Probably regulated by calcium (By similarity). Regulated by PLC gamma, DGKA, DGKZ and by F-actin

polymerization

Genatlas biochemistry entry for RASGRP1:

guanine nucleotide releasing (exchange) protein 1,RAS activator,calcium and DAG-regulated,expressed in the nervous

system

miRNA Products:		miRTarBase miRNAs that target RASGRP1: hsa-mir-21 (MIRT000019)

		OriGene 3'-UTR Clone (see all 2): RASGRP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASGRP1
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RASGRP1 (see all 26):
		hsa-miR-3200-5p hsa-let-7d hsa-miR-202 hsa-miR-548k hsa-miR-487a hsa-let-7c hsa-miR-374a* hsa-miR-511

		SwitchGear 3'UTR luciferase reporter plasmid: RASGRP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGRP1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	TAS	--
GO:0005509	calcium ion binding	IEA	--
GO:0008289	lipid binding	TAS	9582122

RASGRP1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for RASGRP1:

Lamellipodia cells

Animal Models:
Mouse knock-out Rasgrp1^tm1Jstn for RASGRP1
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rasgrp1):

cellular

hematopoietic system

immune system

liver/biliary system

renal/urinary system

RASGRP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling K-RAS regulation pathway

	G-protein signaling K-RAS regulation pathway	1.00			G-protein signaling_H-RAS regulation pathway	0.27
	G-protein signaling_K-RAS regulation pathway	0.96			G-protein signaling H-RAS regulation pathway	0.27

G-protein signaling TC21 regulation pathway

	G-protein signaling TC21 regulation pathway	1.00			G-protein signaling_M-RAS regulation pathway	0.71
	G-protein signaling_TC21 regulation pathway	1.00			G-protein signaling M-RAS regulation pathway	0.71

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for RASGRP1 (see all 7)

	Development Beta-adrenergic receptors regulation of ERK
	G-protein signaling K-RAS regulation pathway
	G-protein signaling N-RAS regulation pathway
	G-protein signaling M-RAS regulation pathway
	G-protein signaling TC21 regulation pathway

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RASGRP1

	ITK and TCR Signaling
	Molecular Mechanisms of Cancer
	Rap1 Pathway

5/7 GeneGo (Thomson Reuters) Pathways for RASGRP1 (see all 7)

	G-protein signaling H-RAS regulation pathway
	G-protein signaling TC21 regulation pathway
	G-protein signaling M-RAS regulation pathway
	G-protein signaling K-RAS regulation pathway
	Immune response T cell receptor signaling pathway

4 BioSystems Pathways for RASGRP1

	MAPK signaling pathway
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	TCR signaling in naive CD4+ T cells
	TCR signaling in naive CD8+ T cells

5/18 Reactome Pathways for RASGRP1 (see all 18)

	GPCR downstream signaling
	Hemostasis
	Integrin cell surface interactions
	Activation of RAS in B Cells
	Gastrin-CREB signalling pathway via PKC and MAPK

2 Kegg Pathways (Kegg details for RASGRP1):

	MAPK signaling pathway
	T cell receptor signaling pathway

RASGRP1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RASGRP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/48 Interacting proteins for RASGRP1 (O95267^{2, 3} ENSP00000310244⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 48)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DGKZ	Q13574³, ENSP00000320340⁴	I2D: score=3 STRING: ENSP00000320340
HRAS	P01112³, ENSP00000309845⁴	I2D: score=2 STRING: ENSP00000309845
PPM1B	O75688³, ENSP00000282412⁴	I2D: score=2 STRING: ENSP00000282412
VHL	P40337³	I2D: score=2
APBB1IP	ENSP00000365411⁴	STRING: ENSP00000365411

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	9789079
GO:0007264	small GTPase mediated signal transduction	--	--
GO:0007265	Ras protein signal transduction	TAS	9582122
GO:0007596	blood coagulation	TAS	--
GO:0030154	cell differentiation	IEA	--

RASGRP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RASGRP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RASGRP1

10/845 HMDB Compounds for RASGRP1 (see all 845) About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--
DG(14:0/18:2(9Z,12Z)/0:0)	DAG(14:0/18:2n6) (see all 15)	--	--

3 Novoseek chemical compound relationships for RASGRP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bryostatin 1	76.2	3	15588099 (1), 10779365 (1), 10807788 (1)
calcium	31.2	14	9582122 (3), 9789079 (2), 10807788 (2), 11503142 (1) (see all 7)
lipid	1.16	2	17523924 (1), 10779365 (1)

Search CenterWatch for drugs/clinical trials and news about RASGRP1 / GRP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RASGRP1 gene (2 alternative transcripts):

NM_001128602.1 NM_005739.3

Unigene Cluster for RASGRP1:

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

Hs.591127 [show with all ESTs]

Unigene Representative Sequence: AF081195

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310803(uc010bbe.3 uc010bbf.3 uc010bbg.3 uc001zke.4 uc001zkd.4)

ENST00000558432 ENST00000561180 ENST00000450598 ENST00000559830 ENST00000414708

ENST00000558164 ENST00000557875 ENST00000560425 ENST00000558418 ENST00000561117

ENST00000560929 ENST00000539159

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		SwitchGear 3'UTR luciferase reporter plasmid: RASGRP1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASGRP1

Additional cDNA sequence:

AB208848.1 AF081195.1 AF081197.1 AF106071.1 AK295097.1 AK314091.1 AK316067.1 AY634315.2

AY858556.2 AY954625.4 AY966005.1 BC032849.1 BC067298.1 BC109296.1 BC109297.1

9 DOTS entries:

DT.452069 DT.91786977 DT.121054866 DT.95257426 DT.121054783 DT.100861292 DT.91744312 DT.91744313

DT.40197398

24/79 AceView cDNA sequences (see all 79):

AA884877 BC067298 AF081197 AW965045 AA283882 BM704085 AA688183 BX456903

BQ049446 AA731879 AA043685 NM_005739 BG778473 AA394197 AA278696 Z39766

AA043684 AI698379 BM918122 BG744494 AA278633 Z43707 AA742351 AA251642

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP1 (see all 11) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	·	11c	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^	17	^
SP1:									-																																								-
SP2:									-																																-		-						-
SP3:									-																																-		-						-		-
SP4:									-																																-		-						-
SP5:					-		-		-

ExUns:	18	^	19	^	20a	·	20b	^	21a	·	21b	·	21c
SP1:
SP2:
SP3:
SP4:					-		-
SP5:

ECgene alternative splicing isoforms for RASGRP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RASGRP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCTAGTGG

About this image

RASGRP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RASGRP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RASGRP1

SOURCE GeneReport for Unigene cluster: Hs.591127

UniProtKB/Swiss-Prot: GRP1_HUMAN, O95267

Tissue specificity: Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in

the hematopoietic system. Expressed in T-cells (at protein level)

SABiosciences Custom PCR Arrays for RASGRP1

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RASGRP1 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RASGRP1¹	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	71.16(n) 74.81(a)		423290 XM_001233088.2 XP_001233089.2
lizard (Anolis carolinensis)	Reptilia	RASGRP1⁶	--	76(a)	1 ↔ 1	1(32678576-32713448)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.18201²	Transcribed sequence with weak similarity to protein more	78.46(n)		AL962936.2
zebrafish (Danio rerio)	Actinopterygii	rasgrp4¹	RAS guanyl releasing protein 4	61.39(n) 58.25(a)		558453 NM_001044862.1 NP_001038327.1
worm (Caenorhabditis elegans)	Secernentea	F25B3.3³	phorbol ester and DAG binding domain	37(a)		V(9559306-9564198) --

ENSEMBL Gene Tree for RASGRP1 (if available)
TreeFam Gene Tree for RASGRP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RASGRP1 gene

RASGRP4² RASGRP2² RASGRP3²

6 SIMAP similar genes for RASGRP1 using alignment to 9 protein entries: GRP1_HUMAN (see all proteins):

RASGRP3 RASGRP2 PRKCH RASGRP4 PRKD1 DKFZp781H1715

RASGRP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77334288^1,2	F,	--	15624621(+)	`AGTTTG/CCTTAG`	2	--	ds500¹		1		WA	118
rs79811767^1,2	F,	--	15624699(+)	`ATTTAT/CAGACT`	2	--	ds500¹		1		WA	118
rs62002956^1,2	F,	--	15624777(+)	`TTCTTC/TGTGTT`	2	--	ds500¹		1		NA	120
rs75466395^1,2	F,	--	15625090(+)	`CACAAC/TGGTCA`	2	--	ut3¹		1		WA	118
rs56976537^1,2	C,	--	15625593(+)	`ATCAAT/ACAAAG`	2	--	ut3¹		2		WA	120
rs4313770^1,2	C,F,H,	--	15627141(+)	`TTTTAG/TATCGC`	2	--	ut3¹		12		NS EA NA	1040
rs72727365^1,2		--	15627848(+)	`TCAACC/TTGGCA`	2	--	int¹		0	--	--	--	--
rs62002957^1,2		--	15628220(+)	`TAATAG/TTGAGC`	2	--	int¹		1		NA	2
rs62002958^1,2		--	15628470(+)	`TACGTT/GATATA`	2	--	int¹		2		NA	122
rs28706611^1,2	C	--	15628764(+)	`TTTCCC/TTTTCA`	2	--	int¹ trp³		0	--	--	--	--

HapMap Linkage Disequilibrium report for RASGRP1 (38780302 - 38857776 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RASGRP1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RASGRP1 for disorders About GeneDecksing

OMIM gene information: 603962 OMIM disorders: --

UniProtKB/Swiss-Prot: GRP1_HUMAN, O95267

Defects in RASGRP1 may contribute to susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is

a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the

skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the

autoimmune system. Note=Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE

patients raising the possibility that dysregulation of this signaling protein contributes to the development of

autoimmunity in a subset of SLE patients

14 diseases for RASGRP1: About MalaCards

systemic lupus erythematosus lupus erythematosus autism spectrum disorder mantle cell lymphoma

myotonic dystrophy acute lymphoblastic leukemia lymphoblastic leukemia acute myeloid leukemia

leukemia/lymphoma myeloid leukemia leukemia breast cancer

cerebritis neuronitis

1 disease from the University of Copenhagen DISEASES database for RASGRP1:

Leukocyte adhesion deficiency

Human Genome Epidemiology (HuGE) Navigator: RASGRP1 (4 documents)

Export disorders for RASGRP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RASGRP1 gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with RASGRP1)

Utopia: connect your pdf to the dynamic
world of online information

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. (PubMed id 9789079)^{1, 2, 3, 9} Kawasaki H.... Graybiel A.M. (1998)
RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions. (PubMed id 10087292)^{1, 2, 3, 9} Bottorff D.A.... Stone J.C. (1999)
Defective expression of ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus. (PubMed id 17878389)^{1, 2, 9} Yasuda S.... Koike T. (2007)
Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. (PubMed id 11257115)^{1, 2, 9} Topham M.K. and Prescott S.M. (2001)
SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1. (PubMed id 17658605)^{1, 2} Kosco K.A....Mustelin T. (2008)
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. (PubMed id 12845332)^{1, 2} Bivona T.G.... Philips M.R. (2003)
Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. (PubMed id 14583629)^{1, 9} Madani S....Charkaoui-Malki M. (2004)
RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. (PubMed id 9582122)^{1, 9} Ebinu J.O....Stone J.C. (1998)
Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. (PubMed id 17283063)^{1, 9} Roose J.P....Weiss A. (2007)
Expression of a catalytically inactive form of diacylglycerol kinase alpha induces sustained signaling through RasGRP. (PubMed id 11919165)^{2, 9} Jones D.R.... Merida I. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10125	HGNC: 9878	AceView: RASGRP1	Ensembl:ENSG00000172575	euGenes: HUgn10125
ECgene: RASGRP1	Kegg: 10125	H-InvDB: RASGRP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RASGRP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RASGRP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RASGRP1 gene:
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GeneCards and IP:
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RASGRP1 Gene

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

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RASGRP1 Gene

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

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