Aliases for RASGRP1 Gene
- RAS Guanyl Releasing Protein 1 (Calcium And DAG-Regulated) 2 3
- Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor II 3 4
- CALDAG-GEFII 3 4
- RASGRP 3 4
- Guanine Nucleotide Exchange Factor, Calcium- And DAG-Regulated, Rap1A 3
- RAS Guanyl Nucleotide-Releasing Protein 1 3
- RAS Guanyl-Releasing Protein 1 3
External Ids for RASGRP1 Gene
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
GeneCards Summary for RASGRP1 Gene
RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium And DAG-Regulated)) is a Protein Coding gene. Diseases associated with RASGRP1 include leukocyte adhesion deficiency and systemic lupus erythematosus. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include calcium ion binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGRP3.
UniProtKB/Swiss-Prot for RASGRP1 Gene
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).