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Aliases for RASGRP1 Gene

Aliases for RASGRP1 Gene

  • RAS Guanyl Releasing Protein 1 2 3 5
  • Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor II 2 3
  • Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor II 3 4
  • RAS Guanyl Releasing Protein 1 (Calcium And DAG-Regulated) 2 3
  • CALDAG-GEFII 3 4
  • RASGRP 3 4
  • Guanine Nucleotide Exchange Factor, Calcium- And DAG-Regulated, Rap1A 3
  • RAS Guanyl Nucleotide-Releasing Protein 1 3
  • RAS Guanyl-Releasing Protein 1 3
  • Ras Guanyl-Releasing Protein 4
  • Ras Activator RasGRP 3
  • CALDAG-GEFI 3
  • HRasGRP1 3
  • V 3

External Ids for RASGRP1 Gene

Previous GeneCards Identifiers for RASGRP1 Gene

  • GC15M034123
  • GC15M031676
  • GC15M036359
  • GC15M036496
  • GC15M036567
  • GC15M038780
  • GC15M015624

Summaries for RASGRP1 Gene

Entrez Gene Summary for RASGRP1 Gene

  • This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

GeneCards Summary for RASGRP1 Gene

RASGRP1 (RAS Guanyl Releasing Protein 1) is a Protein Coding gene. Diseases associated with RASGRP1 include Lupus Erythematosus and Spastic Paraplegia 11, Autosomal Recessive. Among its related pathways are RET signaling and Rap1 signalling. GO annotations related to this gene include calcium ion binding and lipid binding. An important paralog of this gene is RASGRP3.

UniProtKB/Swiss-Prot for RASGRP1 Gene

  • Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).

Gene Wiki entry for RASGRP1 Gene

Additional gene information for RASGRP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRP1 Gene

Genomics for RASGRP1 Gene

Regulatory Elements for RASGRP1 Gene

Enhancers for RASGRP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H038650 1.6 FANTOM5 Ensembl ENCODE dbSUPER 47.1 -86.7 -86660 4.1 KLF1 ZNF687 NR2F1 SIN3A ELF1 CEBPG ZNF592 TARDBP IKZF1 MLLT1 RASGRP1 FAM98B C15orf53 LOC105370775
GH15H038553 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28.6 +5.8 5768 11.9 HDGF PKNOX1 SIN3A ZNF2 GLIS2 GATA2 ZNF143 ZNF207 ATF7 RUNX3 RASGRP1 C15orf53 GC15P038543
GH15H038610 1 FANTOM5 ENCODE dbSUPER 44.2 -45.5 -45491 2.1 CTBP1 GATA3 SCRT2 MAFK RASGRP1 C15orf53 LOC105370775
GH15H038669 1.4 Ensembl ENCODE dbSUPER 23.9 -105.9 -105881 4.6 HDGF PKNOX1 TBL1XR1 RB1 SIN3A ZNF143 ZNF207 ATF7 ETV6 RUNX3 RASGRP1 C15orf53 FAM98B LOC105370775
GH15H038535 1.1 FANTOM5 ENCODE dbSUPER 28.1 +28.9 28898 1.9 PRDM6 ZNF629 CEBPB FEZF1 ATF2 RASGRP1 GC15P038543 ENSG00000259598
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASGRP1 on UCSC Golden Path with GeneCards custom track

Promoters for RASGRP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075161 1075 1001 HDGF PKNOX1 SIN3A ZNF2 GLIS2 ZNF143 ZNF207 RUNX3 REST ZNF592

Genomic Locations for RASGRP1 Gene

Genomic Locations for RASGRP1 Gene
chr15:38,488,101-38,565,575
(GRCh38/hg38)
Size:
77,475 bases
Orientation:
Minus strand
chr15:38,780,302-38,857,776
(GRCh37/hg19)

Genomic View for RASGRP1 Gene

Genes around RASGRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASGRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASGRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRP1 Gene

Proteins for RASGRP1 Gene

  • Protein details for RASGRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95267-GRP1_HUMAN
    Recommended name:
    RAS guanyl-releasing protein 1
    Protein Accession:
    O95267
    Secondary Accessions:
    • Q56CZ0
    • Q58G75
    • Q59HB1
    • Q5I3A8
    • Q6GV31
    • Q6NX39
    • Q7LDG6
    • Q9UI94
    • Q9UNN9

    Protein attributes for RASGRP1 Gene

    Size:
    797 amino acids
    Molecular mass:
    90402 Da
    Quaternary structure:
    • Homodimer (PubMed:23908768). Forms a signaling complex with DGKZ and HRAS (PubMed:11257115). Interacts with F-actin (PubMed:12839994). Interacts with SKAP1 (PubMed:17658605).
    SequenceCaution:
    • Sequence=AAH67298.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RASGRP1 Gene

    Alternative splice isoforms for RASGRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASGRP1 Gene

Post-translational modifications for RASGRP1 Gene

  • Ubiquitination at isoforms=2, 3596
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RASGRP1 Gene

Domains & Families for RASGRP1 Gene

Gene Families for RASGRP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RASGRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95267

UniProtKB/Swiss-Prot:

GRP1_HUMAN :
  • The phorbol-ester/DAG-type zinc finger is the principal mediator of the targeting to membranes and is required for functional activation through DAG-binding.
  • Belongs to the RASGRP family.
Domain:
  • The phorbol-ester/DAG-type zinc finger is the principal mediator of the targeting to membranes and is required for functional activation through DAG-binding.
  • Two EF-hand domains are present. However, only EF-hand 1 (and not EF-hand 2) binds calcium.
Family:
  • Belongs to the RASGRP family.
genes like me logo Genes that share domains with RASGRP1: view

Function for RASGRP1 Gene

Molecular function for RASGRP1 Gene

GENATLAS Biochemistry:
guanine nucleotide releasing (exchange) protein 1,RAS activator,calcium and DAG-regulated,expressed in the nervous system
UniProtKB/Swiss-Prot EnzymeRegulation:
Autoinhibited. Activated by diacylglycerol and calcium binding, which induces a conformational change releasing the autoinhibitory state (PubMed:23908768). Regulated by DGKA (PubMed:11919165). Regulated by DGKZ (PubMed:11257115). Regulated by PLC gamma and F-actin polymerization (PubMed:12839994).
UniProtKB/Swiss-Prot Function:
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).

Phenotypes From GWAS Catalog for RASGRP1 Gene

Gene Ontology (GO) - Molecular Function for RASGRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IMP 23908768
GO:0005085 guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS,IMP --
GO:0005509 calcium ion binding IEA,IMP 23908768
GO:0008270 zinc ion binding IMP 23908768
genes like me logo Genes that share ontologies with RASGRP1: view
genes like me logo Genes that share phenotypes with RASGRP1: view

Animal Models for RASGRP1 Gene

MGI Knock Outs for RASGRP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASGRP1 Gene

Localization for RASGRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASGRP1 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASGRP1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5
nucleus 3
lysosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASGRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with RASGRP1: view

Pathways & Interactions for RASGRP1 Gene

SuperPathways for RASGRP1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling events of B Cell Receptor (BCR)
3 Signaling by GPCR
4 MAPK signaling pathway
5 Developmental Biology
genes like me logo Genes that share pathways with RASGRP1: view

Gene Ontology (GO) - Biological Process for RASGRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001816 cytokine production IEA --
GO:0001934 positive regulation of protein phosphorylation IDA,IMP 23908768
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0007165 signal transduction TAS 9789079
genes like me logo Genes that share ontologies with RASGRP1: view

No data available for SIGNOR curated interactions for RASGRP1 Gene

Drugs & Compounds for RASGRP1 Gene

(3) Drugs for RASGRP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
calcium Nutra 0

(5) Additional Compounds for RASGRP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with RASGRP1: view

Transcripts for RASGRP1 Gene

Unigene Clusters for RASGRP1 Gene

RAS guanyl releasing protein 1 (calcium and DAG-regulated):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: -
SP8: - - - - -
SP9: - - - -
SP10:
SP11: -

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11: -

Relevant External Links for RASGRP1 Gene

GeneLoc Exon Structure for
RASGRP1
ECgene alternative splicing isoforms for
RASGRP1

Expression for RASGRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASGRP1 Gene

mRNA differential expression in normal tissues according to GTEx for RASGRP1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.8) and Brain - Cerebellum (x5.8).

Protein differential expression in normal tissues from HIPED for RASGRP1 Gene

This gene is overexpressed in Pancreatic juice (48.7) and CD8 Tcells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RASGRP1 Gene



Protein tissue co-expression partners for RASGRP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASGRP1 Gene:

RASGRP1

SOURCE GeneReport for Unigene cluster for RASGRP1 Gene:

Hs.591127

mRNA Expression by UniProt/SwissProt for RASGRP1 Gene:

O95267-GRP1_HUMAN
Tissue specificity: Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860).

Evidence on tissue expression from TISSUES for RASGRP1 Gene

  • Nervous system(4.7)
  • Blood(4.5)
genes like me logo Genes that share expression patterns with RASGRP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASGRP1 Gene

Orthologs for RASGRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASGRP1 33 34
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia RASGRP1 33 34
  • 92.01 (n)
cow
(Bos Taurus)
Mammalia RASGRP1 33 34
  • 90.92 (n)
rat
(Rattus norvegicus)
Mammalia Rasgrp1 33
  • 87.1 (n)
oppossum
(Monodelphis domestica)
Mammalia RASGRP1 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasgrp1 33 16 34
  • 86.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RASGRP1 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASGRP1 33 34
  • 71.16 (n)
lizard
(Anolis carolinensis)
Reptilia RASGRP1 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasgrp1 33
  • 68.04 (n)
Str.18201 33
zebrafish
(Danio rerio)
Actinopterygii rasgrp4 33
  • 61.59 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12296 33
worm
(Caenorhabditis elegans)
Secernentea F25B3.3 35
  • 37 (a)
rgef-1 34
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
Species where no ortholog for RASGRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASGRP1 Gene

ENSEMBL:
Gene Tree for RASGRP1 (if available)
TreeFam:
Gene Tree for RASGRP1 (if available)

Paralogs for RASGRP1 Gene

genes like me logo Genes that share paralogs with RASGRP1: view

Variants for RASGRP1 Gene

Sequence variations from dbSNP and Humsavar for RASGRP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000029745 -- 38,504,045(+) TTTGT(A/G)TATCT intron-variant, upstream-variant-2KB
rs1000053756 -- 38,517,703(+) AAGCA(G/T)CCACA intron-variant
rs1000191109 -- 38,542,958(+) ACACA(C/T)ACATA intron-variant
rs1000203505 -- 38,539,891(+) ACAAA(A/G)GACAT intron-variant
rs1000277224 -- 38,539,695(+) TAGGT(A/G)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASGRP1 Gene

Variant ID Type Subtype PubMed ID
esv2749578 CNV deletion 23290073
esv3636194 CNV loss 21293372
esv3636195 CNV loss 21293372
nsv1046994 CNV gain 25217958
nsv525770 CNV gain 19592680

Variation tolerance for RASGRP1 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.38; 81.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASGRP1 Gene

Human Gene Mutation Database (HGMD)
RASGRP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASGRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRP1 Gene

Disorders for RASGRP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RASGRP1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lupus erythematosus
  • systemic lupus erythematosus
spastic paraplegia 11, autosomal recessive
  • hereditary spastic paraplegia 11
systemic lupus erythematosus
  • lupus nephritis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

GRP1_HUMAN
  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:17878389}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.

Relevant External Links for RASGRP1

Genetic Association Database (GAD)
RASGRP1
Human Genome Epidemiology (HuGE) Navigator
RASGRP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASGRP1
genes like me logo Genes that share disorders with RASGRP1: view

No data available for Genatlas for RASGRP1 Gene

Publications for RASGRP1 Gene

  1. RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions. (PMID: 10087292) Bottorff D … Stone JC (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 4 22 60
  2. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. (PMID: 9789079) Kawasaki H … Graybiel AM (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 60
  3. Defective expression of Ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus. (PMID: 17878389) Yasuda S … Koike T (Journal of immunology (Baltimore, Md. : 1950) 2007) 3 4 22 60
  4. Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. (PMID: 11257115) Topham MK … Prescott SM (The Journal of cell biology 2001) 3 4 22 60
  5. RasGRP links T-cell receptor signaling to Ras. (PMID: 10807788) Ebinu JO … Stone JC (Blood 2000) 3 4 22 60

Products for RASGRP1 Gene

Sources for RASGRP1 Gene

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