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Aliases for RASGRP1 Gene

Aliases for RASGRP1 Gene

  • RAS Guanyl Releasing Protein 1 2 3 5
  • Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor II 2 3
  • Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor II 3 4
  • RAS Guanyl Releasing Protein 1 (Calcium And DAG-Regulated) 2 3
  • CALDAG-GEFII 3 4
  • RASGRP 3 4
  • Guanine Nucleotide Exchange Factor, Calcium- And DAG-Regulated, Rap1A 3
  • RAS Guanyl Nucleotide-Releasing Protein 1 3
  • RAS Guanyl-Releasing Protein 1 3
  • Ras Guanyl-Releasing Protein 4
  • Ras Activator RasGRP 3
  • CALDAG-GEFI 3
  • HRasGRP1 3
  • V 3

External Ids for RASGRP1 Gene

Previous GeneCards Identifiers for RASGRP1 Gene

  • GC15M034123
  • GC15M031676
  • GC15M036359
  • GC15M036496
  • GC15M036567
  • GC15M038780
  • GC15M015624

Summaries for RASGRP1 Gene

Entrez Gene Summary for RASGRP1 Gene

  • This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

GeneCards Summary for RASGRP1 Gene

RASGRP1 (RAS Guanyl Releasing Protein 1) is a Protein Coding gene. Diseases associated with RASGRP1 include Spastic Paraplegia 11, Autosomal Recessive and Systemic Lupus Erythematosus. Among its related pathways are RET signaling and MAPK Signaling: Mitogen Stimulation Pathway. GO annotations related to this gene include calcium ion binding and lipid binding. An important paralog of this gene is RASGRP3.

UniProtKB/Swiss-Prot for RASGRP1 Gene

  • Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).

Gene Wiki entry for RASGRP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRP1 Gene

Genomics for RASGRP1 Gene

Regulatory Elements for RASGRP1 Gene

Enhancers for RASGRP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G038650 1.5 FANTOM5 Ensembl ENCODE dbSUPER 47.1 -86.7 -86660 4.1 KLF1 MTA2 BHLHE40 NR2F1 CHD1 CEBPG TBX21 IKZF1 TARDBP TCF7 RASGRP1 FAM98B C15orf53 LOC105370775
GH15G038553 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28.6 +5.8 5768 11.9 HDGF PKNOX1 WRNIP1 ZNF2 GLIS2 GATA2 ZNF143 ZNF207 JUNB REST RASGRP1 C15orf53 GC15P038543
GH15G038610 1.1 FANTOM5 ENCODE dbSUPER 44.2 -45.5 -45491 2.1 CTBP1 GATA3 SCRT2 TBX21 MAFK RASGRP1 C15orf53 LOC105370775
GH15G038669 1.4 Ensembl ENCODE dbSUPER 23.9 -105.9 -105881 4.6 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 ZNF143 ZNF207 RELB ETV6 IKZF2 RASGRP1 C15orf53 FAM98B LOC105370775
GH15G038535 1.1 FANTOM5 ENCODE dbSUPER 28.2 +28.9 28898 1.9 ZNF263 PRDM6 GATA2 ZNF629 CEBPB FEZF1 FOS ATF2 NR2F2 RASGRP1 GC15P038543 ENSG00000259598
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASGRP1 on UCSC Golden Path with GeneCards custom track

Promoters for RASGRP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075161 1075 1001 HDGF PKNOX1 ZNF2 GLIS2 ZNF143 ZNF207 REST SMARCA4 NBN ZNF785

Genomic Location for RASGRP1 Gene

Chromosome:
15
Start:
38,488,101 bp from pter
End:
38,565,575 bp from pter
Size:
77,475 bases
Orientation:
Minus strand

Genomic View for RASGRP1 Gene

Genes around RASGRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASGRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASGRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRP1 Gene

Proteins for RASGRP1 Gene

  • Protein details for RASGRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95267-GRP1_HUMAN
    Recommended name:
    RAS guanyl-releasing protein 1
    Protein Accession:
    O95267
    Secondary Accessions:
    • Q56CZ0
    • Q58G75
    • Q59HB1
    • Q5I3A8
    • Q6GV31
    • Q6NX39
    • Q7LDG6
    • Q9UI94
    • Q9UNN9

    Protein attributes for RASGRP1 Gene

    Size:
    797 amino acids
    Molecular mass:
    90402 Da
    Quaternary structure:
    • Homodimer (PubMed:23908768). Forms a signaling complex with DGKZ and HRAS (PubMed:11257115). Interacts with F-actin (PubMed:12839994). Interacts with SKAP1 (PubMed:17658605).
    SequenceCaution:
    • Sequence=AAH67298.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RASGRP1 Gene

    Alternative splice isoforms for RASGRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASGRP1 Gene

Post-translational modifications for RASGRP1 Gene

  • Ubiquitination at isoforms=2, 3596
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RASGRP1 Gene

Domains & Families for RASGRP1 Gene

Gene Families for RASGRP1 Gene

Suggested Antigen Peptide Sequences for RASGRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95267

UniProtKB/Swiss-Prot:

GRP1_HUMAN :
  • The phorbol-ester/DAG-type zinc finger is the principal mediator of the targeting to membranes and is required for functional activation through DAG-binding.
  • Belongs to the RASGRP family.
Domain:
  • The phorbol-ester/DAG-type zinc finger is the principal mediator of the targeting to membranes and is required for functional activation through DAG-binding.
  • Two EF-hand domains are present. However, only EF-hand 1 (and not EF-hand 2) binds calcium.
Family:
  • Belongs to the RASGRP family.
genes like me logo Genes that share domains with RASGRP1: view

Function for RASGRP1 Gene

Molecular function for RASGRP1 Gene

GENATLAS Biochemistry:
guanine nucleotide releasing (exchange) protein 1,RAS activator,calcium and DAG-regulated,expressed in the nervous system
UniProtKB/Swiss-Prot EnzymeRegulation:
Autoinhibited. Activated by diacylglycerol and calcium binding, which induces a conformational change releasing the autoinhibitory state (PubMed:23908768). Regulated by DGKA (PubMed:11919165). Regulated by DGKZ (PubMed:11257115). Regulated by PLC gamma and F-actin polymerization (PubMed:12839994).
UniProtKB/Swiss-Prot Function:
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).

Gene Ontology (GO) - Molecular Function for RASGRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IMP 23908768
GO:0005085 guanyl-nucleotide exchange factor activity TAS,IEA --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005509 calcium ion binding IMP,IEA 23908768
GO:0008270 zinc ion binding IMP 23908768
genes like me logo Genes that share ontologies with RASGRP1: view
genes like me logo Genes that share phenotypes with RASGRP1: view

Animal Models for RASGRP1 Gene

MGI Knock Outs for RASGRP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASGRP1 Gene

Localization for RASGRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASGRP1 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASGRP1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5
nucleus 3
lysosome 2

Gene Ontology (GO) - Cellular Components for RASGRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with RASGRP1: view

Pathways & Interactions for RASGRP1 Gene

SuperPathways for RASGRP1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling events of B Cell Receptor (BCR)
3 Signaling by GPCR
4 MAPK signaling pathway
5 Developmental Biology
genes like me logo Genes that share pathways with RASGRP1: view

Gene Ontology (GO) - Biological Process for RASGRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001816 cytokine production IEA --
GO:0001934 positive regulation of protein phosphorylation IMP 23908768
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0007165 signal transduction TAS 9789079
genes like me logo Genes that share ontologies with RASGRP1: view

No data available for SIGNOR curated interactions for RASGRP1 Gene

Drugs & Compounds for RASGRP1 Gene

(3) Drugs for RASGRP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
calcium Nutra 0

(5) Additional Compounds for RASGRP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with RASGRP1: view

Transcripts for RASGRP1 Gene

Unigene Clusters for RASGRP1 Gene

RAS guanyl releasing protein 1 (calcium and DAG-regulated):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: -
SP8: - - - - -
SP9: - - - -
SP10:
SP11: -

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11: -

Relevant External Links for RASGRP1 Gene

GeneLoc Exon Structure for
RASGRP1
ECgene alternative splicing isoforms for
RASGRP1

Expression for RASGRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASGRP1 Gene

mRNA differential expression in normal tissues according to GTEx for RASGRP1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.8) and Brain - Cerebellum (x5.8).

Protein differential expression in normal tissues from HIPED for RASGRP1 Gene

This gene is overexpressed in Pancreatic juice (48.7) and CD8 Tcells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RASGRP1 Gene



Protein tissue co-expression partners for RASGRP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASGRP1 Gene:

RASGRP1

SOURCE GeneReport for Unigene cluster for RASGRP1 Gene:

Hs.591127

mRNA Expression by UniProt/SwissProt for RASGRP1 Gene:

O95267-GRP1_HUMAN
Tissue specificity: Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860).

Evidence on tissue expression from TISSUES for RASGRP1 Gene

  • Nervous system(4.7)
  • Blood(4.5)
genes like me logo Genes that share expression patterns with RASGRP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASGRP1 Gene

Orthologs for RASGRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASGRP1 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia RASGRP1 34 35
  • 92.01 (n)
cow
(Bos Taurus)
Mammalia RASGRP1 34 35
  • 90.92 (n)
rat
(Rattus norvegicus)
Mammalia Rasgrp1 34
  • 87.1 (n)
oppossum
(Monodelphis domestica)
Mammalia RASGRP1 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasgrp1 34 16 35
  • 86.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RASGRP1 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASGRP1 34 35
  • 71.16 (n)
lizard
(Anolis carolinensis)
Reptilia RASGRP1 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasgrp1 34
  • 68.04 (n)
Str.18201 34
zebrafish
(Danio rerio)
Actinopterygii rasgrp4 34
  • 61.59 (n)