Aliases for RASGRF2 Gene
External Ids for RASGRF2 Gene
Previous GeneCards Identifiers for RASGRF2 Gene
RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]
GeneCards Summary for RASGRF2 Gene
RASGRF2 (Ras Protein Specific Guanine Nucleotide Releasing Factor 2) is a Protein Coding gene. Among its related pathways are RET signaling and p75 NTR receptor-mediated signalling. GO annotations related to this gene include calmodulin binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGRF1.
UniProtKB/Swiss-Prot for RASGRF2 Gene
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.