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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASGRF2 Gene

protein-coding   GIFtS: 59
GCID: GC05P080292

Ras Protein-Specific Guanine Nucleotide-Releasing Factor...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Protein-Specific Guanine Nucleotide-Releasing Factor 21 2
Ras Guanine Nucleotide Exchange Factor 22 3
GRF22 3
RAS-GRF22
Ras-Specific Guanine Nucleotide-Releasing Factor 22
Ras-GRF23

External Ids:    HGNC: 98761   Entrez Gene: 59242   Ensembl: ENSG000001133197   OMIM: 6066145   UniProtKB: O148273   

Export aliases for RASGRF2 gene to outside databases

Previous GC identifers: GC05P079078 GC05P080495 GC05P080295 GC05P080340 GC05P075465


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RASGRF2 Gene:
RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a
calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the
exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase
pathways. (provided by RefSeq, Oct 2011)

GeneCards Summary for RASGRF2 Gene: 
RASGRF2 (Ras protein-specific guanine nucleotide-releasing factor 2) is a protein-coding gene. Diseases associated with RASGRF2 include orofacial cleft, and colon cancer, and among its related super-pathways are MAPK signaling pathway and NRAGE signals death through JNK. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS2.

UniProtKB/Swiss-Prot: RGRF2_HUMAN, O14827
Function: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the
exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different
types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation

Gene Wiki entry for RASGRF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASGRF2 gene promoter:
         Max1   p53   AML1a   MyoD   HSF1 (long)   HSF1short   ARP-1   TGIF   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASGRF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RASGRF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASGRF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q13

RASGRF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASGRF2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P080292:  view genomic region     (about GC identifiers)

Start:
80,256,491 bp from pter      End:
80,525,975 bp from pter
Size:
269,485 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGRF2_HUMAN, O14827 (See protein sequence)
Recommended Name: Ras-specific guanine nucleotide-releasing factor 2  
Size: 1237 amino acids; 140764 Da
Subunit: Homooligomer and heterooligomer with RASGRF1. Interacts with Ras and RAC1. Interacts in a
calcium-dependent manner with calmodulin (By similarity). Interacts with CDK5R1 and EPB49. Interacts with the
AMPA receptor through GRIA1 (By similarity). Interacts with microtubules (By similarity)
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane;
Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and
along the axon of neurons (By similarity)
Secondary accessions: B9EG89 Q9UK56

Explore the universe of human proteins at neXtProt for RASGRF2: NX_O14827

Explore proteomics data for RASGRF2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CDK5; down-regulates RASGRF2-mediated RAC1 activation
  • UniProtKB: Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14827

  • RASGRF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RASGRF2 Protein Expression
    REFSEQ proteins: NP_008840.1  
    ENSEMBL proteins: 
     ENSP00000265080   ENSP00000421771  
    Reactome Protein details: O14827
    Human Recombinant Protein Products for RASGRF2: 
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    Cloud-Clone Corp. Proteins for RASGRF2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    RASGRF2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    5/9 InterPro protein domains (see all 9):
     IPR008937 Ras_GEF
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR023578 Ras_GEF_dom

    Graphical View of Domain Structure for InterPro Entry O14827

    ProtoNet protein and cluster: O14827

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: RGRF2_HUMAN, O14827
    Domain: The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation
    (By similarity)
    Domain: The IQ domain mediates the calcium-dependent interaction with calmodulin but is dispensable for the
    Ras-GEF activity (By similarity)
    Domain: The DH (DBL-homology) domain mediates interaction with RASGRF1 and EPB49 and is required for RAC1
    activation
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 2 PH domains
    Similarity: Contains 1 Ras-GEF domain


    RASGRF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGRF2_HUMAN, O14827
    Function: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the
    exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different
    types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation

         Genatlas biochemistry entry for RASGRF2:
    guanine nucleotide releasing (exchange) factor,specific,for Ras proteins

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0005543phospholipid binding IEA--
         
    RASGRF2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RASGRF2:
     Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rasgrf2):
     cellular  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     nervous system  normal  reproductive system 

    RASGRF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RASGRF2: Rasgrf2tm1Feig Rasgrf2tm1Esn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RASGRF2 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGRF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RASGRF2 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Cell death signalling via NRAGE, NRIF and NADE
    Cell death signalling via NRAGE, NRIF and NADE0.74
    p75 NTR receptor-mediated signalling0.73
    NRAGE signals death through JNK0.74
    G alpha (12/13) signalling events0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4Post NMDA receptor activation events
    Post NMDA receptor activation events0.89
    CREB phosphorylation through the activation of Ras0.82
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.89
    5Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RASGRF2
        G-protein signaling H-RAS regulation pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RASGRF2
        Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for RASGRF2
        G-protein signaling H-RAS regulation pathway

    2 BioSystems Pathways for RASGRF2
        MAPK signaling pathway
    Regulation of RAC1 activity

    5/17        Reactome Pathways for RASGRF2 (see all 17)
        G alpha (12/13) signalling events
    Transmission across Chemical Synapses
    Cell death signalling via NRAGE, NRIF and NADE
    Post NMDA receptor activation events
    Neuronal System


    1         Kegg Pathway  (Kegg details for RASGRF2):
        MAPK signaling pathway


    RASGRF2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASGRF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/99 Interacting proteins for RASGRF2 (O148273 ENSP000002650804) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRASP011163, ENSP000002560784I2D: score=1 STRING: ENSP00000256078
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    PANK2Q9BZ233, ENSP000003133774I2D: score=2 STRING: ENSP00000313377
    PMVKQ151263, ENSP000003574524I2D: score=1 STRING: ENSP00000357452
    GLRX5Q86SX63I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007268synaptic transmission TAS--
    GO:0035023regulation of Rho protein signal transduction IEA--
    GO:0043065positive regulation of apoptotic process TAS--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--

    RASGRF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RASGRF2 (RGRF2)

    2 HMDB Compounds for RASGRF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RASGRF2 / RGRF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RASGRF2 gene: 
    NM_006909.2  

    Unigene Cluster for RASGRF2:

    Ras protein-specific guanine nucleotide-releasing factor 2
    Hs.162129  [show with all ESTs]
    Unigene Representative Sequence: NM_006909
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265080(uc003kha.2 uc011ctn.2) ENST00000503795 ENST00000514946
    ENST00000502677(uc003khb.1) ENST00000512186
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    Additional mRNA sequence: 

    AF023130.1 AF181250.1 AK092171.1 AK094809.1 BC041953.1 BC126112.1 BC136296.1 BC143870.1 
    CR749239.1 

    6 DOTS entries:

    DT.97838709  DT.40224318  DT.97835592  DT.91790427  DT.91655112  DT.97786705 

    24/87 AceView cDNA sequences (see all 87):

    BQ287786 AI085349 BU735520 BC041953 AI400892 BI918265 AK094809 BM682795 
    NM_006909 BM696935 AF181250 BF433649 AA782778 AI003208 F11414 AI650498 
    BX502901 BM725517 BM720464 BX105416 BM930956 AK092171 AL598102 BM727212 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASGRF2 expression in normal human tissues (normalized intensities)      RASGRF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTCATCTG
    RASGRF2 Expression
    About this image


    RASGRF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud
             kidney ; cells in tubules   

    See RASGRF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASGRF2

    SOURCE GeneReport for Unigene cluster: Hs.162129

    UniProtKB/Swiss-Prot: RGRF2_HUMAN, O14827
    Tissue specificity: Widely expressed with higher expression in brain, followed by heart, lung, pancreas and
    kidney. Detected in placenta. Expressed in brain and lung (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGRF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RASGRF2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasgrf21 , 5 RAS protein-specific guanine nucleotide-releasing factor more1, 5 88.36(n)1
    95.53(a)1
      13 (47.43 cM)5
    194181  NM_009027.31  NP_033053.21 
     918804005 
    chicken
    (Gallus gallus)
    Aves RASGRF21 Ras protein-specific guanine nucleotide-releasing factor more 80.51(n)
    91.26(a)
      100859132  XM_003643077.1  XP_003643125.1 
    lizard
    (Anolis carolinensis)
    Reptilia RASGRF26
    Uncharacterized protein
    87(a)
    1 ↔ 1
    2(17342498-17434827)
    zebrafish
    (Danio rerio)
    Actinopterygii rasgrf2b1 Ras protein-specific guanine nucleotide-releasing factor more 74.18(n)
    86.05(a)
      553520  NM_001128233.1  NP_001121705.1 


    ENSEMBL Gene Tree for RASGRF2 (if available)
    TreeFam Gene Tree for RASGRF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASGRF2 gene
    RALGPS22  RAPGEF12  RASGRF12  RGL22  SOS22  SOS12  RGL32  RALGDS2  
    RALGPS12  RGL42  RGL12  
    2 SIMAP similar genes for RASGRF2 using alignment to 2 protein entries:     RGRF2_HUMAN (see all proteins):
    RASGRF1    FAM109A

    RASGRF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5636 SNPs in RASGRF2 are shown (see all 5636)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0375964
    A breast cancer sample4--see VAR_0375962 D N mis40--------
    VAR_0375954
    A colorectal cancer sample4--see VAR_0375952 R H mis40--------
    VAR_0375984
    A breast cancer sample4--see VAR_0375982 D E mis40--------
    rs1167523391,2
    C--75463418(+) AAATGA/TCCACT 1 -- us2k10--------
    rs341871741,2
    C--75463858(+) GGGGC-/GGGGGG 1 -- us2k11Minor allele frequency- G:0.00CSA 2
    rs1491169891,2
    C--75468678(+) ATCCG-/TTTTTTT 1 -- int10--------
    rs1497047961,2
    C--75470761(+) ATGTT-/TGTGTGT 1 -- int10--------
    rs720602691,2
    C--75470762(+) ATGTT-/TGTG  
            
    TGTGT
    1 -- int10--------
    rs113838391,2
    C--75473030(+) GTACA-/T/TT  
            
    TTTTT
    1 -- int1 trp31CSA 2
    rs2019312241,2
    C--75474047(+) GATCT-/CCCCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for RASGRF2 (80256491 - 80506491 bp, first 250kb of RASGRF2)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RASGRF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678830CNV Deletion23128226
    esv2730380CNV Deletion23290073
    nsv4898CNV Insertion18451855
    esv26734CNV Loss19812545
    nsv830360CNV Loss17160897
    nsv4897CNV Loss18451855
    nsv830358CNV Gain17160897
    nsv882232CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606614    OMIM disorders: --

    4 diseases for RASGRF2:    About MalaCards
    orofacial cleft    colon cancer    lung cancer    neuronitis


    RASGRF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RASGRF2
    Human Genome Epidemiology (HuGE) Navigator: RASGRF2 (1 document)

    Export disorders for RASGRF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASGRF2 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with RASGRF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome wide study of maternal and parent-of-origin eff ects on the etiology of orofacial clefts. (PubMed id 22419666)1, 4 Shi M....Beaty T.H. (2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. (PubMed id 14749369)1, 2 Arozarena I.... Crespo P. (2004)
    4. Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways. (PubMed id 11856323)1, 2 Lutchman M.... Chishti A.H. (2002)
    5. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. (PubMed id 10373510)1, 2 Anborgh P.H....Lowy D.R. (1999)
    6. Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2. (PubMed id 11238945)1, 9 de Hoog C.L....Moran M.F. (2001)
    7. Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene. (PubMed id 9027497)1, 9 Fam N.P....Moran M.F. (1997)
    8. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (2013)
    9. RASGRF2 regulates alcohol-induced reinforcement by inf luencing mesolimbic dopamine neuron activity and dopamine release. (PubMed id 23223532)1 Stacey D....Schumann G. (2012)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5924 HGNC: 9876 AceView: RASGRF2 Ensembl:ENSG00000113319 euGenes: HUgn5924
    ECgene: RASGRF2 Kegg: 5924 H-InvDB: RASGRF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASGRF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RASGRF2 gene:
    Search GeneIP for patents involving RASGRF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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