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RASGRF2 Gene

protein-coding   GIFtS: 58
GCID: GC05P080292

Ras Protein-Specific Guanine Nucleotide-Releasing Factor...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Protein-Specific Guanine Nucleotide-Releasing Factor 21 2
Ras Guanine Nucleotide Exchange Factor 22 3
GRF22 3
RAS-GRF22
Ras-Specific Guanine Nucleotide-Releasing Factor 22
Ras-GRF23

External Ids:    HGNC: 98761   Entrez Gene: 59242   Ensembl: ENSG000001133197   OMIM: 6066145   UniProtKB: O148273   

Export aliases for RASGRF2 gene to outside databases

Previous GC identifers: GC05P079078 GC05P080495 GC05P080295 GC05P080340 GC05P075465


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RASGRF2 Gene:
RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a
calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the
exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase
pathways. (provided by RefSeq, Oct 2011)

GeneCards Summary for RASGRF2 Gene:
RASGRF2 (Ras protein-specific guanine nucleotide-releasing factor 2) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS2.

UniProtKB/Swiss-Prot: RGRF2_HUMAN, O14827
Function: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the
exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different
types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation

Gene Wiki entry for RASGRF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASGRF2 gene promoter:
         Max1   p53   AML1a   MyoD   HSF1 (long)   HSF1short   ARP-1   TGIF   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASGRF2 promoter sequence
   Search Chromatin IP Primers for RASGRF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASGRF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q13

RASGRF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASGRF2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P080292:  view genomic region     (about GC identifiers)

Start:
80,256,491 bp from pter      End:
80,525,975 bp from pter
Size:
269,485 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RGRF2_HUMAN, O14827 (See protein sequence)
Recommended Name: Ras-specific guanine nucleotide-releasing factor 2  
Size: 1237 amino acids; 140764 Da
Subunit: Homooligomer and heterooligomer with RASGRF1. Interacts with Ras and RAC1. Interacts in a
calcium-dependent manner with calmodulin (By similarity). Interacts with CDK5R1 and EPB49. Interacts with the
AMPA receptor through GRIA1 (By similarity). Interacts with microtubules (By similarity)
Secondary accessions: B9EG89 Q9UK56

Explore the universe of human proteins at neXtProt for RASGRF2: NX_O14827

Explore proteomics data for RASGRF2 at MOPED

Post-translational modifications: 

  • Phosphorylated by CDK5; down-regulates RASGRF2-mediated RAC1 activation1
  • Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome (By
    similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASGRF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008840.1  
    ENSEMBL proteins: 
     ENSP00000265080   ENSP00000421771  
    Reactome Protein details: O14827

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 9):
     IPR008937 Ras_GEF
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR023578 Ras_GEF_dom

    Graphical View of Domain Structure for InterPro Entry O14827

    ProtoNet protein and cluster: O14827

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: RGRF2_HUMAN, O14827
    Domain: The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation
    (By similarity)
    Domain: The IQ domain mediates the calcium-dependent interaction with calmodulin but is dispensable for the
    Ras-GEF activity (By similarity)
    Domain: The DH (DBL-homology) domain mediates interaction with RASGRF1 and EPB49 and is required for RAC1
    activation
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 2 PH domains
    Similarity: Contains 1 Ras-GEF domain


    Find genes that share domains with RASGRF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGRF2_HUMAN, O14827
    Function: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the
    exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different
    types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation

         Genatlas biochemistry entry for RASGRF2:
    guanine nucleotide releasing (exchange) factor,specific,for Ras proteins

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
         
    Find genes that share ontologies with RASGRF2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RASGRF2:
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rasgrf2):
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     normal  reproductive system 

    Find genes that share phenotypes with RASGRF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RASGRF2: Rasgrf2tm1Feig Rasgrf2tm1Esn

       genOway: Develop your customized and physiologically relevant rodent model for RASGRF2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGRF2_HUMAN, O14827: Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane;
    Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and
    along the axon of neurons (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    cytosol4
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with RASGRF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RASGRF2 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    CREB phosphorylation through the activation of Ras0.78
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Ras activation uopn Ca2+ infux through NMDA receptor0.00
    3p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    G alpha (12/13) signalling events0.44
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72


    Find genes that share SuperPaths with RASGRF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RASGRF2
        Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for RASGRF2
        G-protein signaling H-RAS regulation pathway

    2 BioSystems Pathways for RASGRF2
        MAPK signaling pathway
    Regulation of RAC1 activity

    4 Reactome Pathways for RASGRF2
        Ras activation uopn Ca2+ infux through NMDA receptor
    G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle


    2 Kegg Pathways  (Kegg details for RASGRF2):
        MAPK signaling pathway
    Ras signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASGRF2
    Interactions:

        Search GeneGlobe Interaction Network for RASGRF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RASGRF2 (O148273 ENSP000002650804) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRASP011163, ENSP000002560784I2D: score=1 STRING: ENSP00000256078
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    PANK2Q9BZ233, ENSP000003133774I2D: score=2 STRING: ENSP00000313377
    PMVKQ151263, ENSP000003574524I2D: score=1 STRING: ENSP00000357452
    GLRX5Q86SX63I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007268synaptic transmission TAS--
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0043065positive regulation of apoptotic process TAS--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--

    Find genes that share ontologies with RASGRF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RASGRF2 (RGRF2)

    2 HMDB Compounds for RASGRF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RASGRF2 gene: 
    NM_006909.2  

    Unigene Cluster for RASGRF2:

    Ras protein-specific guanine nucleotide-releasing factor 2
    Hs.162129  [show with all ESTs]
    Unigene Representative Sequence: NM_006909
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265080(uc003kha.2 uc011ctn.2) ENST00000503795 ENST00000514946
    ENST00000502677(uc003khb.1) ENST00000512186
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    Additional mRNA sequence: 

    AF023130.1 AF181250.1 AK092171.1 AK094809.1 BC041953.1 BC126112.1 BC136296.1 BC143870.1 
    CR749239.1 

    6 DOTS entries:

    DT.97838709  DT.40224318  DT.97835592  DT.91790427  DT.91655112  DT.97786705 

    Selected AceView cDNA sequences (see all 87):

    AK092171 BM930956 AF181250 BM720464 BX105416 AI085349 AL598102 BX502901 
    BM727212 BU735520 BQ287786 AK094809 AI400892 BM725517 AA782778 BC041953 
    BF433649 AI650498 NM_006909 F11414 BI918265 AI003208 BM682795 BM696935 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASGRF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTCATCTG
    RASGRF2 Expression
    About this image


    RASGRF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Line H9 (Naive)
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Ureteric Bud
    RASGRF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASGRF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162129

    UniProtKB/Swiss-Prot: RGRF2_HUMAN, O14827
    Tissue specificity: Widely expressed with higher expression in brain, followed by heart, lung, pancreas and
    kidney. Detected in placenta. Expressed in brain and lung (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RASGRF2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasgrf21 , 5 RAS protein-specific guanine nucleotide-releasing factor more1, 5 88(n)1
    95.03(a)1
      13 (47.43 cM)5
    194181  NM_009027.31  NP_033053.21 
     918804005 
    chicken
    (Gallus gallus)
    Aves RASGRF21 Ras protein-specific guanine nucleotide-releasing factor more 80.51(n)
    91.17(a)
      100859132  XM_004949460.1  XP_004949517.1 
    lizard
    (Anolis carolinensis)
    Reptilia RASGRF26
    Ras protein-specific guanine nucleotide-releasing ...
    87(a)
    1 ↔ 1
    2(17342498-17434827)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rasgrf21 Ras protein-specific guanine nucleotide-releasing factor more 76.09(n)
    86.32(a)
      100486502  XM_002942362.2  XP_002942408.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rasgrf2b1 Ras protein-specific guanine nucleotide-releasing factor more 74.16(n)
    85.97(a)
      553520  NM_001128233.1  NP_001121705.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0012381 AgaP_AGAP001238 56.94(n)
    56.61(a)
      1281933  XM_321917.5  XP_321917.5 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC256
    Membrane bound guanine nucleotide exchange factor ...
    11(a)
    1 → many
    XII(752224-756993) YLR310C


    ENSEMBL Gene Tree for RASGRF2 (if available)
    TreeFam Gene Tree for RASGRF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASGRF2 gene
    RALGPS22  RAPGEF12  RASGRF12  RGL22  SOS22  SOS12  RGL32  RALGDS2  
    RALGPS12  RGL12  RGL42  
    2 SIMAP similar genes for RASGRF2 using alignment to 2 protein entries:     RGRF2_HUMAN (see all proteins):
    RASGRF1    FAM109A

    Find genes that share paralogs with RASGRF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASGRF2 (see all 5636)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0375964
    A breast cancer sample4--see VAR_0375962 D N mis40--------
    VAR_0375954
    A colorectal cancer sample4--see VAR_0375952 R H mis40--------
    VAR_0375984
    A breast cancer sample4--see VAR_0375982 D E mis40--------
    rs1167523391,2
    C--75463418(+) AAATGA/TCCACT 1 -- us2k10--------
    rs341871741,2
    C--75463858(+) GGGGC-/GGGGGG 1 -- us2k11Minor allele frequency- G:0.00CSA 2
    rs1491169891,2
    C--75468678(+) ATCCG-/TTTTTTT 1 -- int10--------
    rs1497047961,2
    C--75470761(+) ATGTT-/TGTGTGT 1 -- int10--------
    rs720602691,2
    C--75470762(+) ATGTT-/TGTG  
            
    TGTGT
    1 -- int10--------
    rs113838391,2
    C--75473030(+) GTACA-/T/TT  
            
    TTTTT
    1 -- int1 trp31CSA 2
    rs2019312241,2
    C--75474047(+) GATCT-/CCCCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for RASGRF2 (80256491 - 80506491 bp, first 250kb of RASGRF2)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RASGRF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678830CNV Deletion23128226
    esv2730380CNV Deletion23290073
    nsv4898CNV Insertion18451855
    esv26734CNV Loss19812545
    nsv830360CNV Loss17160897
    nsv4897CNV Loss18451855
    nsv830358CNV Gain17160897
    nsv882232CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASGRF2
    DNA2.0 Custom Variant and Variant Library Synthesis for RASGRF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606614    OMIM disorders: --


    Find genes that share disorders with RASGRF2           About GenesLikeMe

    Genetic Association Database (GAD): RASGRF2
    Human Genome Epidemiology (HuGE) Navigator: RASGRF2 (1 document)

    Export disorders for RASGRF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASGRF2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with RASGRF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. (PubMed id 22419666)1, 4 Shi M....Beaty T.H. (Am. J. Med. Genet. A 2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. (PubMed id 14749369)1, 2 Arozarena I.... Crespo P. (Mol. Cell. Biol. 2004)
    4. Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways. (PubMed id 11856323)1, 2 Lutchman M.... Chishti A.H. (Eur. J. Biochem. 2002)
    5. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. (PubMed id 10373510)1, 2 Anborgh P.H....Lowy D.R. (Mol. Cell. Biol. 1999)
    6. Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2. (PubMed id 11238945)1, 9 de Hoog C.L....Moran M.F. (Mol. Cell. Biol. 2001)
    7. Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene. (PubMed id 9027497)1, 9 Fam N.P....Moran M.F. (Genomics 1997)
    8. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    9. RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. (PubMed id 23223532)1 Stacey D....Schumann G. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5924 HGNC: 9876 AceView: RASGRF2 Ensembl:ENSG00000113319 euGenes: HUgn5924
    ECgene: RASGRF2 Kegg: 5924 H-InvDB: RASGRF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RASGRF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RASGRF2 gene:
    Search GeneIP for patents involving RASGRF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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