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Aliases for RASGRF2 Gene

Aliases for RASGRF2 Gene

  • Ras Protein-Specific Guanine Nucleotide-Releasing Factor 2 2 3
  • Ras Guanine Nucleotide Exchange Factor 2 3 4
  • RAS-GRF2 3 4
  • GRF2 3 4
  • Ras-Specific Guanine Nucleotide-Releasing Factor 2 3

External Ids for RASGRF2 Gene

Summaries for RASGRF2 Gene

Entrez Gene Summary for RASGRF2 Gene

  • RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]

GeneCards Summary for RASGRF2 Gene

RASGRF2 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and MAPK signaling pathway. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for RASGRF2 Gene

  • Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.

Gene Wiki entry for RASGRF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRF2 Gene

Genomics for RASGRF2 Gene

Genomic Location for RASGRF2 Gene

80,960,672 bp from pter
81,230,162 bp from pter
269,491 bases
Plus strand

Genomic View for RASGRF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASGRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRF2 Gene

Regulatory Elements for RASGRF2 Gene

Proteins for RASGRF2 Gene

  • Protein details for RASGRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-specific guanine nucleotide-releasing factor 2
    Protein Accession:
    Secondary Accessions:
    • B9EG89
    • Q9UK56

    Protein attributes for RASGRF2 Gene

    1237 amino acids
    Molecular mass:
    140764 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with RASGRF1. Interacts with Ras and RAC1. Interacts in a calcium-dependent manner with calmodulin (By similarity). Interacts with CDK5R1 and EPB49. Interacts with the AMPA receptor through GRIA1 (By similarity). Interacts with microtubules (By similarity).

neXtProt entry for RASGRF2 Gene

Proteomics data for RASGRF2 Gene at MOPED

Post-translational modifications for RASGRF2 Gene

  • Phosphorylated by CDK5; down-regulates RASGRF2-mediated RAC1 activation.
  • Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASGRF2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RASGRF2 Gene

Domains for RASGRF2 Gene

Gene Families for RASGRF2 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing
  • ARHGEF :Rho guanine nucleotide exchange factors

Suggested Antigen Peptide Sequences for RASGRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation.:
    • O14827
  • The IQ domain mediates the calcium-dependent interaction with calmodulin but is dispensable for the Ras-GEF activity.:
    • O14827
  • The DH (DBL-homology) domain mediates interaction with RASGRF1 and EPB49 and is required for RAC1 activation:
    • O14827
  • Contains 1 DH (DBL-homology) domain.:
    • O14827
  • Contains 1 IQ domain.:
    • O14827
  • Contains 1 N-terminal Ras-GEF domain.:
    • O14827
  • Contains 2 PH domains.:
    • O14827
  • Contains 1 Ras-GEF domain.:
    • O14827
genes like me logo Genes that share domains with RASGRF2: view

Function for RASGRF2 Gene

Molecular function for RASGRF2 Gene

GENATLAS Biochemistry: guanine nucleotide releasing (exchange) factor,specific,for Ras proteins
UniProtKB/Swiss-Prot Function: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.

Gene Ontology (GO) - Molecular Function for RASGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with RASGRF2: view
genes like me logo Genes that share phenotypes with RASGRF2: view

Animal Models for RASGRF2 Gene

MGI Knock Outs for RASGRF2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RASGRF2 Gene

Localization for RASGRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASGRF2 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RASGRF2 Gene COMPARTMENTS Subcellular localization image for RASGRF2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for RASGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RASGRF2: view

Pathways for RASGRF2 Gene

genes like me logo Genes that share pathways with RASGRF2: view

Pathways by source for RASGRF2 Gene

1 GeneGo (Thomson Reuters) pathway for RASGRF2 Gene
1 Qiagen pathway for RASGRF2 Gene
2 BioSystems pathways for RASGRF2 Gene

Gene Ontology (GO) - Biological Process for RASGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007268 synaptic transmission TAS --
GO:0035023 regulation of Rho protein signal transduction --
GO:0043065 positive regulation of apoptotic process TAS --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RASGRF2: view

Compounds for RASGRF2 Gene

(2) HMDB Compounds for RASGRF2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with RASGRF2: view

Transcripts for RASGRF2 Gene

Unigene Clusters for RASGRF2 Gene

Ras protein-specific guanine nucleotide-releasing factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRF2 Gene

No ASD Table

Relevant External Links for RASGRF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASGRF2 Gene

mRNA expression in normal human tissues for RASGRF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGRF2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.2), Brain - Cortex (5.0), and Brain - Anterior cingulate cortex (BA24) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASGRF2 Gene

SOURCE GeneReport for Unigene cluster for RASGRF2 Gene Hs.162129

mRNA Expression by UniProt/SwissProt for RASGRF2 Gene

Tissue specificity: Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level).
genes like me logo Genes that share expressions with RASGRF2: view

Orthologs for RASGRF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASGRF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RASGRF2 35
  • 99.6 (n)
  • 99.76 (a)
  • 100 (a)
(Bos Taurus)
Mammalia RASGRF2 35
  • 91.64 (n)
  • 96.93 (a)
  • 97 (a)
(Canis familiaris)
Mammalia RASGRF2 35
  • 91.69 (n)
  • 96.19 (a)
  • 95 (a)
(Mus musculus)
Mammalia Rasgrf2 35
  • 88 (n)
  • 95.03 (a)
Rasgrf2 16
Rasgrf2 36
  • 89 (a)
(Monodelphis domestica)
Mammalia RASGRF2 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia RASGRF2 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Rasgrf2 35
  • 88.11 (n)
  • 95.45 (a)
(Gallus gallus)
Aves RASGRF2 35
  • 80.51 (n)
  • 91.17 (a)
  • 91 (a)
(Anolis carolinensis)
Reptilia RASGRF2 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasgrf2 35
  • 76.09 (n)
  • 86.32 (a)
(Danio rerio)
Actinopterygii RASGRF2 (2 of 2) 36
  • 80 (a)
rasgrf2b 35
  • 74.16 (n)
  • 85.97 (a)
rasgrf2b 36
  • 85 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001238 35
  • 56.94 (n)
  • 56.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC25 36
  • 11 (a)
Species with no ortholog for RASGRF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASGRF2 Gene

Gene Tree for RASGRF2 (if available)
Gene Tree for RASGRF2 (if available)

Paralogs for RASGRF2 Gene

Paralogs for RASGRF2 Gene

Selected SIMAP similar genes for RASGRF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASGRF2: view

Variants for RASGRF2 Gene

Sequence variations from dbSNP and Humsavar for RASGRF2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1589 -- 81,101,029(+) CACTT(A/G)GGGCT intron-variant
rs26418 -- 81,083,290(+) TTGCT(A/G)GAGGC intron-variant
rs26419 -- 81,070,663(-) GCTCA(A/C/T)GCACA intron-variant
rs26420 -- 81,068,642(-) AATGT(C/T)CTTTT intron-variant
rs26421 -- 81,067,684(-) TGGCA(C/T)ATGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASGRF2 Gene

Variant ID Type Subtype PubMed ID
nsv830358 CNV Gain 17160897
esv26734 CNV Loss 19812545
esv2678830 CNV Deletion 23128226
nsv830360 CNV Loss 17160897
nsv4897 CNV Loss 18451855
nsv882232 CNV Gain 21882294
esv2730380 CNV Deletion 23290073
nsv4898 CNV Insertion 18451855

Relevant External Links for RASGRF2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRF2 Gene

Disorders for RASGRF2 Gene

Relevant External Links for RASGRF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RASGRF2: view

No data available for UniProtKB/Swiss-Prot for RASGRF2 Gene

Publications for RASGRF2 Gene

  1. Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2. (PMID: 11238945) de Hoog C.L. … Moran M.F. (Mol. Cell. Biol. 2001) 3 23
  2. Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene. (PMID: 9027497) Fam N.P. … Moran M.F. (Genomics 1997) 3 23
  3. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. (PMID: 10373510) Anborgh P.H. … Lowy D.R. (Mol. Cell. Biol. 1999) 3 4
  4. Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. (PMID: 14749369) Arozarena I. … Crespo P. (Mol. Cell. Biol. 2004) 3 4
  5. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. (PMID: 22419666) Shi M. … Beaty T.H. (Am. J. Med. Genet. A 2012) 3 48

Products for RASGRF2 Gene

Sources for RASGRF2 Gene

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