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Aliases for RASGRF2 Gene

Aliases for RASGRF2 Gene

  • Ras Protein Specific Guanine Nucleotide Releasing Factor 2 2 3 5
  • Ras Guanine Nucleotide Exchange Factor 2 3 4
  • RAS-GRF2 3 4
  • GRF2 3 4
  • Ras Protein-Specific Guanine Nucleotide-Releasing Factor 2 3

External Ids for RASGRF2 Gene

Previous GeneCards Identifiers for RASGRF2 Gene

  • GC05P079078
  • GC05P080495
  • GC05P080295
  • GC05P080340
  • GC05P080292
  • GC05P075465

Summaries for RASGRF2 Gene

Entrez Gene Summary for RASGRF2 Gene

  • RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]

GeneCards Summary for RASGRF2 Gene

RASGRF2 (Ras Protein Specific Guanine Nucleotide Releasing Factor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include calmodulin binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for RASGRF2 Gene

  • Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.

Gene Wiki entry for RASGRF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRF2 Gene

Genomics for RASGRF2 Gene

Regulatory Elements for RASGRF2 Gene

Promoters for RASGRF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASGRF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASGRF2 Gene

Chromosome:
5
Start:
80,960,672 bp from pter
End:
81,230,162 bp from pter
Size:
269,491 bases
Orientation:
Plus strand

Genomic View for RASGRF2 Gene

Genes around RASGRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASGRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASGRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRF2 Gene

Proteins for RASGRF2 Gene

  • Protein details for RASGRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14827-RGRF2_HUMAN
    Recommended name:
    Ras-specific guanine nucleotide-releasing factor 2
    Protein Accession:
    O14827
    Secondary Accessions:
    • B9EG89
    • Q9UK56

    Protein attributes for RASGRF2 Gene

    Size:
    1237 amino acids
    Molecular mass:
    140764 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with RASGRF1. Interacts with Ras and RAC1. Interacts in a calcium-dependent manner with calmodulin (By similarity). Interacts with CDK5R1 and EPB49. Interacts with the AMPA receptor through GRIA1 (By similarity). Interacts with microtubules (By similarity).

neXtProt entry for RASGRF2 Gene

Proteomics data for RASGRF2 Gene at MOPED

Post-translational modifications for RASGRF2 Gene

  • Phosphorylated by CDK5; down-regulates RASGRF2-mediated RAC1 activation.
  • Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASGRF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RASGRF2 Gene

Domains & Families for RASGRF2 Gene

Suggested Antigen Peptide Sequences for RASGRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14827

UniProtKB/Swiss-Prot:

RGRF2_HUMAN :
  • The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation.
Domain:
  • The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation.
  • The IQ domain mediates the calcium-dependent interaction with calmodulin but is dispensable for the Ras-GEF activity.
  • The DH (DBL-homology) domain mediates interaction with RASGRF1 and EPB49 and is required for RAC1 activation.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 IQ domain.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 2 PH domains.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RASGRF2: view

Function for RASGRF2 Gene

Molecular function for RASGRF2 Gene

GENATLAS Biochemistry:
guanine nucleotide releasing (exchange) factor,specific,for Ras proteins
UniProtKB/Swiss-Prot Function:
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
genes like me logo Genes that share phenotypes with RASGRF2: view

Animal Models for RASGRF2 Gene

MGI Knock Outs for RASGRF2:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RASGRF2 Gene

Localization for RASGRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASGRF2 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASGRF2 Gene COMPARTMENTS Subcellular localization image for RASGRF2 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
plasma membrane 5
nucleus 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for RASGRF2 Gene

Pathways & Interactions for RASGRF2 Gene

SuperPathways for RASGRF2 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 p75 NTR receptor-mediated signalling
3 Post NMDA receptor activation events
4 Signaling by GPCR
5 Transmission across Chemical Synapses
genes like me logo Genes that share pathways with RASGRF2: view

Pathways by source for RASGRF2 Gene

1 GeneGo (Thomson Reuters) pathway for RASGRF2 Gene
1 Qiagen pathway for RASGRF2 Gene

Gene Ontology (GO) - Biological Process for RASGRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007268 synaptic transmission TAS --
GO:0007411 axon guidance TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with RASGRF2: view

No data available for SIGNOR curated interactions for RASGRF2 Gene

Drugs & Compounds for RASGRF2 Gene

(2) Drugs for RASGRF2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
calcium Nutra 0
genes like me logo Genes that share compounds with RASGRF2: view

Transcripts for RASGRF2 Gene

Unigene Clusters for RASGRF2 Gene

Ras protein-specific guanine nucleotide-releasing factor 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRF2 Gene

No ASD Table

Relevant External Links for RASGRF2 Gene

GeneLoc Exon Structure for
RASGRF2
ECgene alternative splicing isoforms for
RASGRF2

Expression for RASGRF2 Gene

mRNA expression in normal human tissues for RASGRF2 Gene

mRNA differential expression in normal tissues according to GTEx for RASGRF2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.2), Brain - Cortex (x5.0), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for RASGRF2 Gene

This gene is overexpressed in Frontal cortex (36.6) and Plasma (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASGRF2 Gene



SOURCE GeneReport for Unigene cluster for RASGRF2 Gene Hs.162129

mRNA Expression by UniProt/SwissProt for RASGRF2 Gene

O14827-RGRF2_HUMAN
Tissue specificity: Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level).
genes like me logo Genes that share expression patterns with RASGRF2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for RASGRF2 Gene

Orthologs for RASGRF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASGRF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASGRF2 35
  • 91.64 (n)
  • 96.93 (a)
RASGRF2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASGRF2 35
  • 91.69 (n)
  • 96.19 (a)
RASGRF2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasgrf2 35
  • 88 (n)
  • 95.03 (a)
Rasgrf2 16
Rasgrf2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RASGRF2 35
  • 99.6 (n)
  • 99.76 (a)
RASGRF2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasgrf2 35
  • 88.11 (n)
  • 95.45 (a)
oppossum
(Monodelphis domestica)
Mammalia RASGRF2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASGRF2 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASGRF2 35
  • 80.51 (n)
  • 91.17 (a)
RASGRF2 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASGRF2 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasgrf2 35
  • 76.09 (n)
  • 86.32 (a)
zebrafish
(Danio rerio)
Actinopterygii rasgrf2b 35
  • 74.16 (n)
  • 85.97 (a)
RASGRF2 (2 of 2) 36
  • 80 (a)
OneToMany
rasgrf2b 36
  • 85 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001238 35
  • 56.94 (n)
  • 56.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC25 36
  • 11 (a)
OneToMany
Species with no ortholog for RASGRF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASGRF2 Gene

ENSEMBL:
Gene Tree for RASGRF2 (if available)
TreeFam:
Gene Tree for RASGRF2 (if available)

Paralogs for RASGRF2 Gene

Paralogs for RASGRF2 Gene

(2) SIMAP similar genes for RASGRF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASGRF2: view

Variants for RASGRF2 Gene

Sequence variations from dbSNP and Humsavar for RASGRF2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_037595 A colorectal cancer sample
VAR_037596 A breast cancer sample
rs16878472 - 81,113,588(+) ACATT(G/T)GGTGG reference, missense
VAR_037598 A breast cancer sample
rs1589 -- 81,101,029(+) CACTT(A/G)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASGRF2 Gene

Variant ID Type Subtype PubMed ID
nsv830358 CNV Gain 17160897
esv26734 CNV Loss 19812545
esv2678830 CNV Deletion 23128226
nsv830360 CNV Loss 17160897
nsv4897 CNV Loss 18451855
nsv882232 CNV Gain 21882294
esv2730380 CNV Deletion 23290073
nsv4898 CNV Insertion 18451855

Variation tolerance for RASGRF2 Gene

Residual Variation Intolerance Score: 8.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.93; 67.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASGRF2 Gene

HapMap Linkage Disequilibrium report
RASGRF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRF2 Gene

Disorders for RASGRF2 Gene

Relevant External Links for RASGRF2

Genetic Association Database (GAD)
RASGRF2
Human Genome Epidemiology (HuGE) Navigator
RASGRF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASGRF2

No disorders were found for RASGRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASGRF2 Gene

Publications for RASGRF2 Gene

  1. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. (PMID: 22419666) Shi M. … Beaty T.H. (Am. J. Med. Genet. A 2012) 3 48 67
  2. Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2. (PMID: 11238945) de Hoog C.L. … Moran M.F. (Mol. Cell. Biol. 2001) 3 23
  3. Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene. (PMID: 9027497) Fam N.P. … Moran M.F. (Genomics 1997) 3 23
  4. I^Arrestin1 regulates the guanine nucleotide exchange factor RasGRF2 expression and the small GTPase Rac-mediated formation of membrane protrusion and cell motility. (PMID: 24692549) Ma X. … Daaka Y. (J. Biol. Chem. 2014) 3
  5. Common variants at 1p36 are associated with superior frontal gyrus volume. (PMID: 25335168) Hashimoto R. … Ozaki N. (Transl Psychiatry 2014) 3

Products for RASGRF2 Gene

Sources for RASGRF2 Gene

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