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Aliases for RASGRF1 Gene

Aliases for RASGRF1 Gene

  • Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 2 3
  • Ras-Specific Nucleotide Exchange Factor CDC25 3 4
  • Guanine Nucleotide-Releasing Protein 3 4
  • Ras-GRF1 3 4
  • CDC25 3 4
  • GRF1 3 4
  • GNRP 3 4
  • Ras-Specific Guanine Nucleotide-Releasing Factor, CDC25 Homolog 3
  • Ras-Specific Guanine Nucleotide-Releasing Factor 1 3
  • Guanine Nucleotide-Releasing Factor, 55 KD 3
  • Guanine Nucleotide-Releasing Factor 1 3
  • Guanine Nucleotide Exchange Factor 3
  • H-GRF55 3
  • PP13187 3
  • CDC25L 3
  • GRF55 3

External Ids for RASGRF1 Gene

Previous HGNC Symbols for RASGRF1 Gene

  • GRF1

Previous GeneCards Identifiers for RASGRF1 Gene

  • GC15P075083
  • GC15M072411
  • GC15M076830
  • GC15M076970
  • GC15M077041
  • GC15M079252
  • GC15M056012

Summaries for RASGRF1 Gene

Entrez Gene Summary for RASGRF1 Gene

  • The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

GeneCards Summary for RASGRF1 Gene

RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for RASGRF1 Gene

  • Promotes the exchange of Ras-bound GDP by GTP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRF1 Gene

Genomics for RASGRF1 Gene

Regulatory Elements for RASGRF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASGRF1 Gene

Start:
78,959,947 bp from pter
End:
79,090,873 bp from pter
Size:
130,927 bases
Orientation:
Minus strand

Genomic View for RASGRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASGRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRF1 Gene

Proteins for RASGRF1 Gene

  • Protein details for RASGRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13972-RGRF1_HUMAN
    Recommended name:
    Ras-specific guanine nucleotide-releasing factor 1
    Protein Accession:
    Q13972
    Secondary Accessions:
    • F8VPA5
    • H0YKF2
    • J3KQP9
    • Q16027

    Protein attributes for RASGRF1 Gene

    Size:
    1273 amino acids
    Molecular mass:
    145234 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability (By similarity).

    Alternative splice isoforms for RASGRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASGRF1 Gene

Proteomics data for RASGRF1 Gene at MOPED

Post-translational modifications for RASGRF1 Gene

  • Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome.
  • Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.
  • Ubiquitinated and degraded following phosphorylation by PLK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASGRF1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RASGRF1 Gene

Domains for RASGRF1 Gene

Gene Families for RASGRF1 Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for RASGRF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13972

UniProtKB/Swiss-Prot:

RGRF1_HUMAN :
  • Q13972
Domain:
  • The DH (DBL-homology) domain mediates interaction with RASGRF2
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 IQ domain.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 2 PH domains.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RASGRF1: view

Function for RASGRF1 Gene

Molecular function for RASGRF1 Gene

GENATLAS Biochemistry: guanine nucleotide releasing factor (55kDa),specific for Ras proteins
UniProtKB/Swiss-Prot Function: Promotes the exchange of Ras-bound GDP by GTP.

Gene Ontology (GO) - Molecular Function for RASGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity TAS 1379731
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS 7684828
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding --
GO:0035254 glutamate receptor binding IEA --
genes like me logo Genes that share ontologies with RASGRF1: view
genes like me logo Genes that share phenotypes with RASGRF1: view

Animal Models for RASGRF1 Gene

MGI Knock Outs for RASGRF1:

Animal Model Products

CRISPR Products

miRNA for RASGRF1 Gene

miRTarBase miRNAs that target RASGRF1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASGRF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RASGRF1 Gene

Localization for RASGRF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASGRF1 Gene COMPARTMENTS Subcellular localization image for RASGRF1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RASGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane TAS --
GO:0030426 growth cone ISS --
GO:0043005 neuron projection NAS 10918068
genes like me logo Genes that share ontologies with RASGRF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASGRF1 Gene

Pathways for RASGRF1 Gene

genes like me logo Genes that share pathways with RASGRF1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RASGRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7684828
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007268 synaptic transmission TAS --
GO:0007616 long-term memory NAS 10918068
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with RASGRF1: view

Compounds for RASGRF1 Gene

(1) HMDB Compounds for RASGRF1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(7) Novoseek inferred chemical compound relationships for RASGRF1 Gene

Compound -log(P) Hits PubMed IDs
gdp 75.9 8
guanine 64.5 8
gtp 59.6 7
tyrosine 39.3 7
ionomycin 29.2 3
genes like me logo Genes that share compounds with RASGRF1: view

Transcripts for RASGRF1 Gene

Unigene Clusters for RASGRF1 Gene

Ras protein-specific guanine nucleotide-releasing factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASGRF1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRF1 Gene

No ASD Table

Relevant External Links for RASGRF1 Gene

GeneLoc Exon Structure for
RASGRF1
ECgene alternative splicing isoforms for
RASGRF1

Expression for RASGRF1 Gene

mRNA expression in normal human tissues for RASGRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGRF1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (7.5), Brain - Cerebellum (6.9), Brain - Frontal Cortex (BA9) (6.1), Brain - Cortex (6.1), Brain - Anterior cingulate cortex (BA24) (5.4), and Brain - Spinal cord (cervical c-1) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASGRF1 Gene

SOURCE GeneReport for Unigene cluster for RASGRF1 Gene Hs.459035

genes like me logo Genes that share expressions with RASGRF1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RASGRF1 Gene

Orthologs for RASGRF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASGRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASGRF1 35
  • 99.66 (n)
  • 99.76 (a)
RASGRF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASGRF1 35
  • 92.12 (n)
  • 98.25 (a)
RASGRF1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASGRF1 35
  • 90.65 (n)
  • 97.01 (a)
RASGRF1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasgrf1 35
  • 84.37 (n)
  • 85.01 (a)
Rasgrf1 16
Rasgrf1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASGRF1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASGRF1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasgrf1 35
  • 83.83 (n)
  • 85.2 (a)
chicken
(Gallus gallus)
Aves RASGRF1 35
  • 83.45 (n)
  • 92.52 (a)
RASGRF1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASGRF1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasgrf1 35
  • 74.99 (n)
  • 84.18 (a)
zebrafish
(Danio rerio)
Actinopterygii ralgps1 36
  • 13 (a)
ManyToMany
si:ch211-234p18.3 35
  • 78.98 (n)
  • 89.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC25 36
  • 11 (a)
OneToMany
Species with no ortholog for RASGRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASGRF1 Gene

ENSEMBL:
Gene Tree for RASGRF1 (if available)
TreeFam:
Gene Tree for RASGRF1 (if available)

Paralogs for RASGRF1 Gene

Paralogs for RASGRF1 Gene

Selected SIMAP similar genes for RASGRF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RASGRF1: view

Variants for RASGRF1 Gene

Sequence variations from dbSNP and Humsavar for RASGRF1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs729650 -- 79,066,968(-) AGAGC(A/G)AGGCC intron-variant
rs734446 -- 79,035,840(-) CTAGC(A/G)TTTTC intron-variant
rs734447 -- 79,035,671(-) GCCCC(C/T)CTCTG intron-variant
rs736554 -- 79,035,344(+) CTGCA(C/T)CGGCA intron-variant
rs736827 -- 79,066,524(+) GAGCT(A/G)TAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASGRF1 Gene

Variant ID Type Subtype PubMed ID
esv33573 CNV Gain+Loss 17666407
nsv904433 CNV Gain 21882294
esv2749917 CNV Deletion 23290073
esv2660956 CNV Deletion 23128226
esv1000067 CNV Deletion 20482838
esv2749920 CNV Deletion 23290073
nsv509577 CNV Insertion 20534489
nsv525630 CNV Loss 19592680
dgv758e1 CNV Complex 17122850
nsv827410 CNV Gain 20364138

Relevant External Links for RASGRF1 Gene

HapMap Linkage Disequilibrium report
RASGRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRF1 Gene

Disorders for RASGRF1 Gene

Relevant External Links for RASGRF1

Genetic Association Database (GAD)
RASGRF1
Human Genome Epidemiology (HuGE) Navigator
RASGRF1
genes like me logo Genes that share disorders with RASGRF1: view

No data available for UniProtKB/Swiss-Prot for RASGRF1 Gene

Publications for RASGRF1 Gene

  1. Identification of a human guanine nucleotide-releasing factor (H- GRF55) specific for Ras proteins. (PMID: 7684828) Schweighoffer F. … Tocque B. (Oncogene 1993) 2 3 4 23
  2. Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae. (PMID: 1379731) Wei W. … Broek D. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23
  3. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. (PMID: 10373510) Anborgh P.H. … Lowy D.R. (Mol. Cell. Biol. 1999) 3 4 23
  4. G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm). (PMID: 10220378) Kiyono M. … Kaziro Y. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 23
  5. Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1. (PMID: 10882715) Kiyono M. … Satoh T. (J. Biol. Chem. 2000) 3 23

Products for RASGRF1 Gene

Sources for RASGRF1 Gene

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