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RASGEF1C Gene

protein-coding   GIFtS: 48
GCID: GC05M179527

RasGEF Domain Family, Member 1C

  Search for RASGEF1C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RasGEF Domain Family, Member 1C1 2
Ras-GEF Domain-Containing Family Member 1C2

External Ids:    HGNC: 274001   Entrez Gene: 2554262   Ensembl: ENSG000001460907   UniProtKB: Q8N4313   

Export aliases for RASGEF1C gene to outside databases

Previous GC identifers: GC05M179637 GC05M179460 GC05M174252


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RASGEF1C Gene:
RASGEF1C (RasGEF domain family, member 1C) is a protein-coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RAPGEFL1.

UniProtKB/Swiss-Prot: RGF1C_HUMAN, Q8N431
Function: Guanine nucleotide exchange factor (GEF) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASGEF1C gene promoter:
         Bach1   Max1   c-Fos   AP-1   JunB   FosB   Fra-1   Ik-3   JunD   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RASGEF1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASGEF1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

RASGEF1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASGEF1C gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M179527:  view genomic region     (about GC identifiers)

Start:
179,527,795 bp from pter      End:
179,636,153 bp from pter
Size:
108,359 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RGF1C_HUMAN, Q8N431 (See protein sequence)
Recommended Name: Ras-GEF domain-containing family member 1C  
Size: 466 amino acids; 52870 Da
Sequence caution: Sequence=AAH36802.1; Type=Erroneous initiation;
Secondary accessions: D3DWQ7 Q7Z4T0 Q8NA49
Alternative splicing: 2 isoforms:  Q8N431-1   Q8N431-2   

Explore the universe of human proteins at neXtProt for RASGEF1C: NX_Q8N431

Explore proteomics data for RASGEF1C at MOPED


See RASGEF1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_778232.2  
ENSEMBL proteins: 
 ENSP00000354963   ENSP00000377037   ENSP00000429114   ENSP00000430659  

RASGEF1C Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for RASGEF1C

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LSBio Antibodies in human, mouse, rat for RASGEF1C

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Cloud-Clone Corp. ELISAs for RASGEF1C
Cloud-Clone Corp. CLIAs for RASGEF1C


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:
 IPR008937 Ras_GEF
 IPR023578 Ras_GEF_dom
 IPR001895 RasGRF_CDC25
 IPR019804 Ras_G-nucl-exch_fac_CS
 IPR000651 Ras-like_Gua-exchang_fac_N

Graphical View of Domain Structure for InterPro Entry Q8N431

ProtoNet protein and cluster: Q8N431

1 Blocks protein domain: IPB001895 Guanine-nucleotide dissociation stimulator CDC25

UniProtKB/Swiss-Prot: RGF1C_HUMAN, Q8N431
Similarity: Contains 1 N-terminal Ras-GEF domain
Similarity: Contains 1 Ras-GEF domain


RASGEF1C for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RGF1C_HUMAN, Q8N431
Function: Guanine nucleotide exchange factor (GEF) (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005085guanyl-nucleotide exchange factor activity IEA--
     
RASGEF1C for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for RASGEF1C:
 Synthetic lethal with Ras 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASGEF1C
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASGEF1C
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASGEF1C

miRNA
Products:
    
miRTarBase miRNAs that target RASGEF1C:
hsa-mir-335-5p (MIRT018443)

Block miRNA regulation of human, mouse, rat RASGEF1C using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate RASGEF1C:
hsa-miR-1236 hsa-miR-1827 hsa-miR-1291
SwitchGear 3'UTR luciferase reporter plasmidRASGEF1C 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for RASGEF1C
Predesigned siRNA for gene silencing in human, mouse, rat RASGEF1C

Gene Editing
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GenScript: all cDNA clones in your preferred vector: RASGEF1C (NM_175062)
Sino Biological Human cDNA Clone for RASGEF1C
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASGEF1C

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGEF1C


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus2
golgi apparatus1
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular IEA--

RASGEF1C for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASGEF1C
Interactions:

    Search GeneGlobe Interaction Network for RASGEF1C

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for RASGEF1C (Q8N4312, 3 ENSP000003549634) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TNK2Q079122, 3, ENSP000003713414MINT-64705 I2D: score=3 STRING: ENSP00000371341
TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
POT1Q9NUX53, ENSP000003502494I2D: score=1 STRING: ENSP00000350249
TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007264small GTPase mediated signal transduction IEA--
GO:0051056regulation of small GTPase mediated signal transduction IEA--

RASGEF1C for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RASGEF1C (RGF1C)

3 HMDB Compounds for RASGEF1C    About this table
CompoundSynonyms CAS #PubMed Ids
Guanosine diphosphate5'-GDP (see all 10)146-91-8--
Guanosine monophosphate5'-GMP (see all 14)85-32-5--
Guanosine triphosphate5'-GTP (see all 10)86-01-1--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RASGEF1C gene (2 alternative transcripts): 
NM_001031799.1  NM_175062.3  

Unigene Cluster for RASGEF1C:

RasGEF domain family, member 1C
Hs.190559  [show with all ESTs]
Unigene Representative Sequence: AF449764
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000361132(uc003mlr.3) ENST00000393371(uc003mlq.3) ENST00000522500(uc003mlp.4)
ENST00000520209 ENST00000519456 ENST00000519883
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat RASGEF1C using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate RASGEF1C:
hsa-miR-1236 hsa-miR-1827 hsa-miR-1291
SwitchGear 3'UTR luciferase reporter plasmidRASGEF1C 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat RASGEF1C
Clone
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GenScript: all cDNA clones in your preferred vector: RASGEF1C (NM_175062)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASGEF1C
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASGEF1C
  QuantiTect SYBR Green Assays in human, mouse, rat RASGEF1C
  QuantiFast Probe-based Assays in human, mouse, rat RASGEF1C

Additional mRNA sequence: 

AF449764.1 AK093160.1 BC036802.1 

4 DOTS entries:

DT.303157  DT.97824670  DT.101974061  DT.101977725 

Selected AceView cDNA sequences (see all 26):

BI910446 AX747963 BM907118 BF967301 AF449764 BF345750 NM_175062 BC036802 
BI464742 BC057759 BG911967 AI828026 BQ879966 AK093160 BM729117 BM682046 
AW183201 BF345910 BM544439 BG716984 BX103029 AI698708 AA889254 AA991494 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RASGEF1C    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:        -                 -     -                                               -                           
SP2:                          -     -                                               -                           
SP3:                                                                                                            
SP4:                                                                                -                           


ECgene alternative splicing isoforms for RASGEF1C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RASGEF1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGTTACAGT
RASGEF1C Expression
About this image


RASGEF1C expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Testis (Reproductive System)
         Sertoli cells Seminiferous Tubules
RASGEF1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RASGEF1C Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.190559
    Custom PCR Arrays for RASGEF1C
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGEF1C

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RASGEF1C gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rasgef1c1 , 5 RasGEF domain family, member 1C1, 5 88.05(n)1
94.64(a)1
  11 (30.02 cM)5
745631  NM_029004.11  NP_083280.11 
 499018355 
chicken
(Gallus gallus)
Aves RASGEF1C1 RasGEF domain family, member 1C 75.91(n)
83.66(a)
  416296  NM_001277274.1  NP_001264203.1 
lizard
(Anolis carolinensis)
Reptilia RASGEF1C6
RasGEF domain family, member 1C
81(a)
1 ↔ 1
2(141529693-141563808)
fruit fly
(Drosophila melanogaster)
Insecta CG73696
CG48536
(see all 3)
--
32(a)
25(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
3L(22734893-22741714)
2R(13401710-13404950)
worm
(Caenorhabditis elegans)
Secernentea R05G6.106
Protein R05G6.10 (R05G6.10) mRNA, complete cds
36(a)
1 → many
IV(7517446-7520365) WBGene00019902


ENSEMBL Gene Tree for RASGEF1C (if available)
TreeFam Gene Tree for RASGEF1C (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RASGEF1C gene
RAPGEFL12  RAPGEF22  RAPGEF62  RASGEF1A2  RAPGEF32  RAPGEF42  ENSG000002732172  RASGEF1B2  
RAPGEF52  
2 SIMAP similar genes for RASGEF1C using alignment to 2 protein entries:     RGF1C_HUMAN (see all proteins):
RASGEF1B    RASGEF1A

RASGEF1C for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RASGEF1C (see all 2735)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2017326391,2
C--179527376(+) CATCCA/GCCACC 1 -- ds50010--------
rs44150511,2
C,F,H--179527505(+) AGTTTG/TTGAGG 1 -- ds500116Minor allele frequency- T:0.23NS EA NA WA CSA 793
rs18674481,2
C,F,O,A,H--179527641(-) CAGTTC/AACCTT 1 -- ds500127Minor allele frequency- A:0.40MN NS EA NA WA CSA 2671
rs1147041861,2
F--179527658(+) CCCCAC/TGCACC 1 -- ds50011Minor allele frequency- T:0.03WA 118
rs1837586781,2
--179527684(+) GACACA/GGGGTC 1 -- ds50010--------
rs1434188931,2
--179527721(+) CCATGA/CCTGAA 1 -- ds50010--------
rs780398141,2
F--179527778(+) GTGGAC/TGTGGG 1 -- ds50011Minor allele frequency- T:0.03WA 118
rs1885142171,2
--179527857(+) CTGCCA/GTGTAC 1 -- ut310--------
rs22786621,2
C,F,O,A,H--179527895(-) CGTCAG/ACAGGA 1 -- ut31 ese333Minor allele frequency- A:0.16EA NA NS WA CSA 4407
rs598033781,2
C,F--179527901(+) TGACGC/TGTTCC 1 -- ut311Minor allele frequency- T:0.50WA 2

HapMap Linkage Disequilibrium report for RASGEF1C (179527795 - 179636153 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for RASGEF1C (see all 20):    About this table    
Variant IDTypeSubtypePubMed ID
esv2731322CNV Deletion23290073
esv2084548CNV Deletion18987734
esv2731318CNV Deletion23290073
esv1357659CNV Deletion17803354
esv2731319CNV Deletion23290073
esv2670240CNV Deletion23128226
esv2731320CNV Deletion23290073
esv1492604CNV Deletion17803354
esv2731321CNV Deletion23290073
esv2731316CNV Deletion23290073

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RASGEF1C
DNA2.0 Custom Variant and Variant Library Synthesis for RASGEF1C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RASGEF1C for disorders           About GeneDecksing

Genetic Association Database (GAD): RASGEF1C

Export disorders for RASGEF1C gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RASGEF1C gene integrated from 10 sources:
(articles sorted by number of sources associating them with RASGEF1C)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (PLoS ONE 2010)
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
  7. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 255426 HGNC: 27400 AceView: RASGEF1C Ensembl:ENSG00000146090 euGenes: HUgn255426
ECgene: RASGEF1C H-InvDB: RASGEF1C

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RASGEF1C Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RASGEF1C gene:
Search GeneIP for patents involving RASGEF1C

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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