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Aliases for RASGEF1C Gene

Aliases for RASGEF1C Gene

  • RasGEF Domain Family Member 1C 2 3 5

External Ids for RASGEF1C Gene

Previous GeneCards Identifiers for RASGEF1C Gene

  • GC05M179637
  • GC05M179460
  • GC05M174252
  • GC05M179527

Summaries for RASGEF1C Gene

GeneCards Summary for RASGEF1C Gene

RASGEF1C (RasGEF Domain Family Member 1C) is a Protein Coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGEF1B.

UniProtKB/Swiss-Prot for RASGEF1C Gene

  • Guanine nucleotide exchange factor (GEF).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGEF1C Gene

Genomics for RASGEF1C Gene

Regulatory Elements for RASGEF1C Gene

Enhancers for RASGEF1C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F180208 0.7 FANTOM5 11.4 +1.0 1025 0.1 ZNF701 ZKSCAN1 MAML1 MAPK9 PRDX2P3 RASGEF1C ENSG00000248367 MRNIP LOC646058
GH05F180126 0.7 Ensembl 6.4 +81.6 81641 1.1 ZNF48 ZNF2 RAD21 GLIS2 ZNF143 FOS EGR2 ZNF263 ZNF654 ZBTB2 RNF130 RASGEF1C LOC646058
GH05F180176 1.4 FANTOM5 Ensembl ENCODE 6.3 +31.7 31700 1.3 ELF3 TFAP4 SAP130 ZFP64 CEBPG ZNF48 ZNF644 RARA TEAD3 ZNF121 RASGEF1C LOC646058
GH05F180172 1.3 Ensembl ENCODE 4.7 +35.5 35524 3.1 BCOR SAP130 ZMYM3 CEBPG GLI4 ZIC2 RARA ZNF121 GLIS2 ZNF548 MAML1 RNF130 RASGEF1C LOC646058
GH05F179972 0.5 FANTOM5 1.3 +236.2 236183 0.2 ZNF585B ZNF879 LOC100996419 ZFP62 RNF130 ZNF354C TBC1D9B MIR340 RN7SKP150 MRNIP CNOT6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RASGEF1C on UCSC Golden Path with GeneCards custom track

Promoters for RASGEF1C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001877164 -47 801 ZSCAN5A CTCF CBX3 ZNF223 KLF17 UBTF ZIC2 RAD21 HIC1 E2F1

Genomic Location for RASGEF1C Gene

180,100,791 bp from pter
180,209,153 bp from pter
108,363 bases
Minus strand

Genomic View for RASGEF1C Gene

Genes around RASGEF1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASGEF1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASGEF1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGEF1C Gene

Proteins for RASGEF1C Gene

  • Protein details for RASGEF1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-GEF domain-containing family member 1C
    Protein Accession:
    Secondary Accessions:
    • D3DWQ7
    • Q7Z4T0
    • Q8NA49

    Protein attributes for RASGEF1C Gene

    466 amino acids
    Molecular mass:
    52870 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36802.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RASGEF1C Gene


neXtProt entry for RASGEF1C Gene

Post-translational modifications for RASGEF1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASGEF1C Gene

No data available for DME Specific Peptides for RASGEF1C Gene

Domains & Families for RASGEF1C Gene

Suggested Antigen Peptide Sequences for RASGEF1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RASGEF1C: view

No data available for Gene Families for RASGEF1C Gene

Function for RASGEF1C Gene

Molecular function for RASGEF1C Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF).

Gene Ontology (GO) - Molecular Function for RASGEF1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with RASGEF1C: view
genes like me logo Genes that share phenotypes with RASGEF1C: view

Animal Model Products

miRNA for RASGEF1C Gene

miRTarBase miRNAs that target RASGEF1C

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASGEF1C Gene

Localization for RASGEF1C Gene

Subcellular locations from

Jensen Localization Image for RASGEF1C Gene COMPARTMENTS Subcellular localization image for RASGEF1C gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for RASGEF1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RASGEF1C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASGEF1C Gene

Pathways & Interactions for RASGEF1C Gene

SuperPathways for RASGEF1C Gene

No Data Available

Interacting Proteins for RASGEF1C Gene

SIGNOR curated interactions for RASGEF1C Gene


Gene Ontology (GO) - Biological Process for RASGEF1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RASGEF1C: view

No data available for Pathways by source for RASGEF1C Gene

Drugs & Compounds for RASGEF1C Gene

(3) Drugs for RASGEF1C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RASGEF1C: view

Transcripts for RASGEF1C Gene

Unigene Clusters for RASGEF1C Gene

RasGEF domain family, member 1C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGEF1C Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - -
SP4: -

Relevant External Links for RASGEF1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASGEF1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASGEF1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGEF1C Gene

This gene is overexpressed in Brain - Cerebellum (x9.8) and Brain - Cerebellar Hemisphere (x9.3).

Protein differential expression in normal tissues from HIPED for RASGEF1C Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASGEF1C Gene

Protein tissue co-expression partners for RASGEF1C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RASGEF1C Gene:


SOURCE GeneReport for Unigene cluster for RASGEF1C Gene:

genes like me logo Genes that share expression patterns with RASGEF1C: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RASGEF1C Gene

Orthologs for RASGEF1C Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGEF1C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RASGEF1C 34 35
  • 99.21 (n)
(Canis familiaris)
Mammalia RASGEF1C 34 35
  • 91.2 (n)
(Rattus norvegicus)
Mammalia Rasgef1c 34
  • 88.2 (n)
(Mus musculus)
Mammalia Rasgef1c 34 16 35
  • 88.05 (n)
(Bos Taurus)
Mammalia RASGEF1C 35
  • 88 (a)
(Monodelphis domestica)
Mammalia RASGEF1C 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia RASGEF1C 35
  • 76 (a)
(Gallus gallus)
Aves RASGEF1C 34 35
  • 75.91 (n)
(Anolis carolinensis)
Reptilia RASGEF1C 35
  • 81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7369 35
  • 32 (a)
CG4853 35
  • 25 (a)
CG34393 35
  • 19 (a)
(Caenorhabditis elegans)
Secernentea R05G6.10 35
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 21 (a)
Species where no ortholog for RASGEF1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RASGEF1C Gene

Gene Tree for RASGEF1C (if available)
Gene Tree for RASGEF1C (if available)

Paralogs for RASGEF1C Gene

(2) SIMAP similar genes for RASGEF1C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASGEF1C: view

Variants for RASGEF1C Gene

Sequence variations from dbSNP and Humsavar for RASGEF1C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10037005 -- 180,145,410(+) gccac(C/T)gtgcc intron-variant
rs10039790 -- 180,182,311(+) ggtgg(A/G)tttgt intron-variant
rs10040706 -- 180,190,451(+) cgcca(C/T)tgcac intron-variant
rs10041337 -- 180,116,703(+) GGAAG(C/T)AGTGC intron-variant
rs10043453 -- 180,204,722(+) AGAGG(A/C)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASGEF1C Gene

Variant ID Type Subtype PubMed ID
esv1357659 CNV deletion 17803354
esv1492604 CNV deletion 17803354
esv2084548 CNV deletion 18987734
esv2591777 CNV insertion 19546169
esv2670240 CNV deletion 23128226
esv2731316 CNV deletion 23290073
esv2731318 CNV deletion 23290073
esv2731319 CNV deletion 23290073
esv2731320 CNV deletion 23290073
esv2731321 CNV deletion 23290073
esv2731322 CNV deletion 23290073
esv2759398 CNV gain 17122850
esv2763868 CNV loss 21179565
esv3392751 CNV duplication 20981092
esv3567111 CNV deletion 23714750
esv3570600 CNV loss 25503493
esv3570601 CNV loss 25503493
esv3607765 CNV gain 21293372
esv3607766 CNV loss 21293372
esv3890774 CNV loss 25118596
nsv1020038 CNV gain 25217958
nsv1021754 CNV loss 25217958
nsv1030036 CNV gain 25217958
nsv1033460 CNV loss 25217958
nsv1033706 CNV gain 25217958
nsv1073524 CNV deletion 25765185
nsv1122122 CNV deletion 24896259
nsv472058 CNV novel sequence insertion 20440878
nsv512864 CNV insertion 21212237
nsv525160 CNV loss 19592680
nsv528625 CNV loss 19592680
nsv830561 CNV loss 17160897
nsv830562 CNV loss 17160897

Variation tolerance for RASGEF1C Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASGEF1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGEF1C Gene

Disorders for RASGEF1C Gene

Relevant External Links for RASGEF1C

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RASGEF1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASGEF1C Gene

Publications for RASGEF1C Gene

  1. Rap1 and Rap2 antagonistically control endothelial barrier resistance. (PMID: 23469100) Pannekoek W.J. … Rehmann H. (PLoS ONE 2013) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PMID: 20811636) Giannone R.J. … Liu Y. (PLoS ONE 2010) 3 64
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for RASGEF1C Gene

Sources for RASGEF1C Gene

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