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Aliases for RASGEF1C Gene

Aliases for RASGEF1C Gene

  • RasGEF Domain Family, Member 1C 2 3

External Ids for RASGEF1C Gene

Previous GeneCards Identifiers for RASGEF1C Gene

  • GC05M179637
  • GC05M179460
  • GC05M174252
  • GC05M179527

Summaries for RASGEF1C Gene

GeneCards Summary for RASGEF1C Gene

RASGEF1C (RasGEF Domain Family, Member 1C) is a Protein Coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGEF1B.

UniProtKB/Swiss-Prot for RASGEF1C Gene

  • Guanine nucleotide exchange factor (GEF).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGEF1C Gene

Genomics for RASGEF1C Gene

Regulatory Elements for RASGEF1C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASGEF1C Gene

Start:
180,100,791 bp from pter
End:
180,209,153 bp from pter
Size:
108,363 bases
Orientation:
Minus strand

Genomic View for RASGEF1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASGEF1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGEF1C Gene

Proteins for RASGEF1C Gene

  • Protein details for RASGEF1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N431-RGF1C_HUMAN
    Recommended name:
    Ras-GEF domain-containing family member 1C
    Protein Accession:
    Q8N431
    Secondary Accessions:
    • D3DWQ7
    • Q7Z4T0
    • Q8NA49

    Protein attributes for RASGEF1C Gene

    Size:
    466 amino acids
    Molecular mass:
    52870 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36802.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RASGEF1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASGEF1C Gene

Proteomics data for RASGEF1C Gene at MOPED

Post-translational modifications for RASGEF1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASGEF1C Gene

No data available for DME Specific Peptides for RASGEF1C Gene

Domains for RASGEF1C Gene

Suggested Antigen Peptide Sequences for RASGEF1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N431

UniProtKB/Swiss-Prot:

RGF1C_HUMAN :
  • Q8N431
Domain:
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RASGEF1C: view

No data available for Gene Families for RASGEF1C Gene

Function for RASGEF1C Gene

Molecular function for RASGEF1C Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF).

Gene Ontology (GO) - Molecular Function for RASGEF1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with RASGEF1C: view

Phenotypes for RASGEF1C Gene

GenomeRNAi human phenotypes for RASGEF1C:
genes like me logo Genes that share phenotypes with RASGEF1C: view

Animal Model Products

CRISPR Products

miRNA for RASGEF1C Gene

miRTarBase miRNAs that target RASGEF1C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASGEF1C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RASGEF1C Gene

Localization for RASGEF1C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASGEF1C Gene COMPARTMENTS Subcellular localization image for RASGEF1C gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RASGEF1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RASGEF1C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASGEF1C Gene

Pathways for RASGEF1C Gene

SuperPathways for RASGEF1C Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASGEF1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RASGEF1C: view

No data available for Pathways by source for RASGEF1C Gene

Compounds for RASGEF1C Gene

(3) HMDB Compounds for RASGEF1C Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RASGEF1C: view

Transcripts for RASGEF1C Gene

Unigene Clusters for RASGEF1C Gene

RasGEF domain family, member 1C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASGEF1C

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RASGEF1C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGEF1C Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for RASGEF1C Gene

GeneLoc Exon Structure for
RASGEF1C
ECgene alternative splicing isoforms for
RASGEF1C

Expression for RASGEF1C Gene

mRNA expression in normal human tissues for RASGEF1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGEF1C Gene

This gene is overexpressed in Brain - Cerebellum (9.8) and Brain - Cerebellar Hemisphere (9.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RASGEF1C Gene

SOURCE GeneReport for Unigene cluster for RASGEF1C Gene Hs.190559

genes like me logo Genes that share expressions with RASGEF1C: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RASGEF1C Gene

Orthologs for RASGEF1C Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGEF1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASGEF1C 35
  • 99.21 (n)
  • 99.79 (a)
RASGEF1C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASGEF1C 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASGEF1C 35
  • 91.2 (n)
  • 94.21 (a)
RASGEF1C 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasgef1c 35
  • 88.05 (n)
  • 94.64 (a)
Rasgef1c 16
Rasgef1c 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASGEF1C 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASGEF1C 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasgef1c 35
  • 88.2 (n)
  • 94.85 (a)
chicken
(Gallus gallus)
Aves RASGEF1C 35
  • 75.91 (n)
  • 83.66 (a)
RASGEF1C 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASGEF1C 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34393 36
  • 19 (a)
ManyToMany
CG4853 36
  • 25 (a)
ManyToMany
CG7369 36
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R05G6.10 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for RASGEF1C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RASGEF1C Gene

ENSEMBL:
Gene Tree for RASGEF1C (if available)
TreeFam:
Gene Tree for RASGEF1C (if available)

Paralogs for RASGEF1C Gene

Selected SIMAP similar genes for RASGEF1C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASGEF1C: view

Variants for RASGEF1C Gene

Sequence variations from dbSNP and Humsavar for RASGEF1C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs744250 -- 180,177,447(-) CGTGG(A/T)CTGCT intron-variant
rs744251 -- 180,177,487(-) GGCAG(C/G)GGTCC intron-variant
rs744252 -- 180,177,486(-) GCAGG(A/G)GTCCC intron-variant
rs750493 -- 180,177,899(+) GAAAC(A/G)GAGCC intron-variant
rs882701 -- 180,171,718(-) GGTGT(C/T)TGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASGEF1C Gene

Variant ID Type Subtype PubMed ID
nsv830561 CNV Loss 17160897
nsv883287 CNV Loss 21882294
esv2731316 CNV Deletion 23290073
dgv1881e1 CNV Complex 17122850
nsv883288 CNV Loss 21882294
esv2731318 CNV Deletion 23290073
esv2731319 CNV Deletion 23290073
esv2084548 CNV Deletion 18987734
esv1492604 CNV Deletion 17803354
esv2731320 CNV Deletion 23290073
esv2731321 CNV Deletion 23290073
esv1357659 CNV Deletion 17803354
nsv830562 CNV Loss 17160897
nsv512864 CNV Insertion 21212237
esv2591777 CNV Insertion 19546169
nsv525160 CNV Loss 19592680
nsv883289 CNV Loss 21882294
esv2731322 CNV Deletion 23290073
esv2670240 CNV Deletion 23128226
nsv528625 CNV Loss 19592680

Relevant External Links for RASGEF1C Gene

HapMap Linkage Disequilibrium report
RASGEF1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGEF1C Gene

Disorders for RASGEF1C Gene

Relevant External Links for RASGEF1C

Genetic Association Database (GAD)
RASGEF1C
genes like me logo Genes that share disorders with RASGEF1C: view

No data available for UniProtKB/Swiss-Prot for RASGEF1C Gene

Publications for RASGEF1C Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PMID: 20811636) Giannone R.J. … Liu Y. (PLoS ONE 2010) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for RASGEF1C Gene

Sources for RASGEF1C Gene

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