RASGEF1C Gene
protein-coding GIFtS: 47
GCID: GC05M179527
|
|
RasGEF domain family, member 1C
| |
Aliases
for RASGEF1C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RasGEF Domain Family, Member 1C1 2 | | FLJ358411 | | Ras-GEF Domain-Containing Family Member 1C2 |
Export aliases for RASGEF1C gene to outside databasesPrevious GC identifers: GC05M179637 GC05M179460 GC05M174252 |
Summaries
for RASGEF1C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RGF1C_HUMAN, Q8N431Function: Guanine nucleotide exchange factor (GEF) (By similarity)
|
Genomic Views
for RASGEF1C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RASGEF1C gene promoter:
Bach1 Max1 c-Fos AP-1 JunB FosB Fra-1 Ik-3 JunD c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for RASGEF1C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASGEF1C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3RASGEF1C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M179527: view genomic region
(about GC identifiers)
Start:
|
179,527,795 bp from pter |
End:
|
179,636,153 bp from pter |
Size:
|
108,359 bases |
Orientation:
|
minus strand |
|
Proteins
for RASGEF1C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RGF1C_HUMAN, Q8N431 (See
protein sequence)Recommended Name: Ras-GEF domain-containing family member 1C Size: 466 amino acids; 52870 Da
Sequence caution: Sequence=AAH36802.1; Type=Erroneous initiation;
Secondary accessions: D3DWQ7 Q7Z4T0 Q8NA49Alternative splicing: 2 isoforms: Q8N431-1 Q8N431-2 Explore the universe of human proteins at neXtProt for RASGEF1C: NX_Q8N431
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N431
RASGEF1C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_778232.2
ENSEMBL proteins: ENSP00000354963 ENSP00000377037 ENSP00000429114 ENSP00000430659
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
RASGEF1C for ontologies About GeneDecksing
RASGEF1C Antibody Products:
Assay Products for RASGEF1C: |
Protein
Domains /
Families
for RASGEF1C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RASGEF1C for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N431ProtoNet protein and cluster: Q8N431 1 Blocks protein family: IPB001895 Guanine-nucleotide dissociation stimulator CDC25
UniProtKB/Swiss-Prot: RGF1C_HUMAN, Q8N431Similarity: Contains 1 N-terminal Ras-GEF domainSimilarity: Contains 1 Ras-GEF domain |
Function
for RASGEF1C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RGF1C_HUMAN, Q8N431Function: Guanine nucleotide exchange factor (GEF) (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASGEF1C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASGEF1C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RASGEF1C (NM_175062) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RASGEF1C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASGEF1C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGEF1C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity |
IEA | -- |
RASGEF1C for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RASGEF1C:
|
Pathways & Interactions
for RASGEF1C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASGEF1C
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for RASGEF1C (Q8N4312, 3 ENSP000003549634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0051056 | regulation of small GTPase mediated signal transduction |
IEA | -- |
RASGEF1C for ontologies About GeneDecksing
|
Drugs & Compounds
for RASGEF1C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RASGEF1C
3 HMDB Compounds for RASGEF1C About this table
Search CenterWatch for drugs/clinical trials and news about RASGEF1C / RGF1C
|
Transcripts
for RASGEF1C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RASGEF1C gene (2 alternative transcripts): NM_001031799.1 NM_175062.3 Unigene Cluster for RASGEF1C: RasGEF domain family, member 1C Hs.190559 [show with all ESTs]Unigene Representative Sequence: AF4497646 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361132(uc003mlr.3) ENST00000393371(uc003mlq.3) ENST00000522500(uc003mlp.4)
ENST00000520209 ENST00000519456 ENST00000519883
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASGEF1C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASGEF1C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RASGEF1C (NM_175062) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RASGEF1C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASGEF1C |
Additional cDNA sequence: AF449764.1 AK093160.1 BC036802.1 4 DOTS entries: DT.303157 DT.97824670 DT.101974061 DT.101977725 24/26 AceView cDNA sequences (see all 26): AX747963 BG911967 AK093160 AF449764 BC036802 BF345910 BF967301 BM729117 BG716984 AI828026 BF345750 BI464742 BM907118 BM682046 BQ879966 AW183201 BI910446 NM_175062 BM544439 BC057759 AI698708 BX103029 AA889254 AA991494
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RASGEF1C About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for RASGEF1C
|
Expression
for RASGEF1C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RASGEF1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTTACAGT
About this image
See RASGEF1C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RASGEF1C
SOURCE GeneReport for Unigene cluster: Hs.190559
SABiosciences Custom PCR Arrays for RASGEF1C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASGEF1C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RASGEF1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASGEF1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASGEF1C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGEF1C |
Orthologs
for RASGEF1C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RASGEF1C gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for RASGEF1C (if available)
TreeFam Gene Tree for RASGEF1C (if available) |
Paralogs
for RASGEF1C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RASGEF1C gene
- RAPGEF22 RAPGEFL12 RAPGEF62 RAPGEF42 RASGEF1A2 RAPGEF32 RAPGEF52 RASGEF1B2
2 SIMAP similar genes for RASGEF1C using alignment to 2 protein entries: RGF1C_HUMAN (see all proteins):RASGEF1B RASGEF1A
RASGEF1C for paralogs About GeneDecksing
|
Genomic Variants
for RASGEF1C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RASGEF1C (179527795 - 179636153 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for RASGEF1C
2 CNVs: 4482 3591
3 Indels: 27886 99381 46836 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RASGEF1C |
|
Disorders
/ Diseases
for RASGEF1C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RASGEF1C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RASGEF1C gene integrated from 9 sources:
(articles sorted by number of sources associating them with RASGEF1C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for RASGEF1C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RASGEF1C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RASGEF1C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RASGEF1C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RASGEF1C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RASGEF1C gene:
Search GeneIP for patents involving RASGEF1C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RASGEF1C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RASGEF1C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RASGEF1C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASGEF1C | | | OriGene Protein Over-expression Lysate for RASGEF1C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RASGEF1C | | OriGene 3'-UTR Clone for RASGEF1C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASGEF1C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASGEF1C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RASGEF1C | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RASGEF1C | | OriGene Custom Protein Services for RASGEF1C | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RASGEF1C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RASGEF1C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASGEF1C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASGEF1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASGEF1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASGEF1C |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | RASGEF1C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGEF1C |
|  |  |  | | | | Search ThermoFisher Antibodies for RASGEF1C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASGEF1C |
|
|
|
|
