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RASGEF1B Gene

protein-coding   GIFtS: 50
GCID: GC04M082348

RasGEF Domain Family, Member 1B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RasGEF Domain Family, Member 1B1 2
GPIG42 3 5
GPI Gamma-42 3
GPI-Gamma 42
Ras-GEF Domain-Containing Family Member 1B2

External Ids:    HGNC: 248811   Entrez Gene: 1530202   Ensembl: ENSG000001386707   OMIM: 6145325   UniProtKB: Q0VAM23   
ORGUL members:         

Export aliases for RASGEF1B gene to outside databases

Previous GC identifers: GC04M082806 GC04M082705 GC04M082567 GC04M078092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RASGEF1B Gene:
RASGEF1B (RasGEF domain family, member 1B) is a protein-coding gene. Diseases associated with RASGEF1B include myocarditis, and short stature. GO annotations related to this gene include Ras guanyl-nucleotide exchange factor activity. An important paralog of this gene is RAPGEFL1.

UniProtKB/Swiss-Prot: RGF1B_HUMAN, Q0VAM2
Function: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other
Ras family proteins (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASGEF1B gene promoter:
         Sox5   ATF-2   CUTL1   AP-2gamma   Evi-1   POU2F1   FOXO4   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASGEF1B promoter sequence
   Search Chromatin IP Primers for RASGEF1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASGEF1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.21   Ensembl cytogenetic band:  4q21.22   HGNC cytogenetic band: 4q21.21

RASGEF1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASGEF1B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M082348:  view genomic region     (about GC identifiers)

Start:
82,347,547 bp from pter      End:
82,965,397 bp from pter
Size:
617,851 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RGF1B_HUMAN, Q0VAM2 (See protein sequence)
Recommended Name: Ras-GEF domain-containing family member 1B  
Size: 473 amino acids; 55359 Da
Subunit: Interacts with Ras family proteins (By similarity). Interacts with CCDC124 during cytokinesis
Secondary accessions: Q0VAM1 Q4W5L7 Q4W5M3 Q96MY8
Alternative splicing: 3 isoforms:  Q0VAM2-1   Q0VAM2-2   Q0VAM2-3   

Explore the universe of human proteins at neXtProt for RASGEF1B: NX_Q0VAM2

Explore proteomics data for RASGEF1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASGEF1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689758.1  
    ENSEMBL proteins: 
     ENSP00000425393   ENSP00000264400   ENSP00000338437   ENSP00000426929   ENSP00000398763  
     ENSP00000476065  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR008937 Ras_GEF
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR019804 Ras_G-nucl-exch_fac_CS
     IPR000651 Ras-like_Gua-exchang_fac_N

    Graphical View of Domain Structure for InterPro Entry Q0VAM2

    ProtoNet protein and cluster: Q0VAM2

    1 Blocks protein domain: IPB001895 Guanine-nucleotide dissociation stimulator CDC25

    UniProtKB/Swiss-Prot: RGF1B_HUMAN, Q0VAM2
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 Ras-GEF domain


    RASGEF1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGF1B_HUMAN, Q0VAM2
    Function: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other
    Ras family proteins (in vitro)
    Induction: Up-regulated in macrophages stimulated with IFNG, GPI-mucins or bacterial lipopolysaccharides (LPS)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005088Ras guanyl-nucleotide exchange factor activity IDA19645719
         
    RASGEF1B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RASGEF1B:
     Increased cell number in G1, a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASGEF1B
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    Selected qRT-PCR Assays for microRNAs that regulate RASGEF1B (see all 25):
    hsa-miR-3685 hsa-miR-15a hsa-miR-128 hsa-miR-503 hsa-miR-513c hsa-miR-764 hsa-miR-373* hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidRASGEF1B 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGF1B_HUMAN, Q0VAM2: Early endosome (By similarity). Late endosome (By similarity). Midbody. Note=May shuttle
    between early and late endosomes (By similarity). Localizes to midbody at telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    endosome2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005769early endosome IEA--
    GO:0005770late endosome IEA--
    GO:0030496midbody IEA--

    RASGEF1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASGEF1B
    Interactions:

        Search GeneGlobe Interaction Network for RASGEF1B

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for RASGEF1B (ENSP000002644004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESPL1ENSP000002579344STRING: ENSP00000257934
    NCAPHENSP000002404234STRING: ENSP00000240423
    PPP6CENSP000003921474STRING: ENSP00000392147
    DUSP23ENSP000003570874STRING: ENSP00000357087
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0032318regulation of Ras GTPase activity IDA19645719
    GO:0051056regulation of small GTPase mediated signal transduction ----

    RASGEF1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASGEF1B (RGF1B)

    3 HMDB Compounds for RASGEF1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RASGEF1B gene: 
    NM_152545.1  

    Unigene Cluster for RASGEF1B:

    RasGEF domain family, member 1B
    Hs.591696  [show with all ESTs]
    Unigene Representative Sequence: BX648337
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509081 ENST00000264400(uc003hmi.1 uc003hmj.1 uc010ijq.1)
    ENST00000335927 ENST00000504863 ENST00000436139(uc003hmk.3) ENST00000514889
    ENST00000507538 ENST00000512716
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RASGEF1B (see all 25):
    hsa-miR-3685 hsa-miR-15a hsa-miR-128 hsa-miR-503 hsa-miR-513c hsa-miR-764 hsa-miR-373* hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidRASGEF1B 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat RASGEF1B
      QuantiFast Probe-based Assays in human, mouse, rat RASGEF1B

    Additional mRNA sequence: 

    AK056257.1 AK291459.1 AK303625.1 BC036784.1 BC121003.1 BC121004.1 BX648337.1 

    5 DOTS entries:

    DT.70100308  DT.101965900  DT.99932981  DT.40232024  DT.95194801 

    21 AceView cDNA sequences:

    AK056257 NM_152545 AI379474 CA444856 CA305891 AW444812 BM742022 BM455562 
    BX648337 CA307173 BG740692 BX279621 CB130147 BC036784 AA327467 AW082493 
    BM549797 BU430765 BI041319 CA396061 AV733616 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RASGEF1B    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                      -                 -                                                                           
    SP2:                                      -                 -                                                                           
    SP3:                                      -                 -                                                                           
    SP4:                                      -                                                                                             
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for RASGEF1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASGEF1B expression in normal human tissues (normalized intensities)      RASGEF1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAATCACAG
    RASGEF1B Expression
    About this image


    RASGEF1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Spinal Cord (Nervous System)
             Oligodendrocyte-like cells
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Brain (Nervous System)
             Oligodendrocyte-like cells
    RASGEF1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASGEF1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591696
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASGEF1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASGEF1B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasgef1b1 , 5 RasGEF domain family, member 1B1, 5 87.32(n)1
    97.46(a)1
      5 (48.46 cM)5
    3202921  NM_145839.21  NP_665838.11 
     992174265 
    chicken
    (Gallus gallus)
    Aves RASGEF1B1 RasGEF domain family, member 1B 82.42(n)
    92.8(a)
      100859744  XM_003641169.2  XP_003641217.2 
    lizard
    (Anolis carolinensis)
    Reptilia RASGEF1B6
    RasGEF domain family, member 1B
    82(a)
    1 ↔ 1
    5(42549705-42815405)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ069621.12   -- 78.99(n)    BJ069621.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055678.12   -- 75.69(n)   327572  BC055678.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73691 CG7369 54.91(n)
    51.83(a)
      2768961  NM_141158.4  NP_649415.2 
    worm
    (Caenorhabditis elegans)
    Secernentea R05G6.101 R05G6.10 51.25(n)
    40.14(a)
      177527  NM_068816.4  NP_501217.2 


    ENSEMBL Gene Tree for RASGEF1B (if available)
    TreeFam Gene Tree for RASGEF1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASGEF1B gene
    RAPGEFL12  RAPGEF22  RAPGEF62  RASGEF1A2  RAPGEF32  RASGEF1C2  RAPGEF42  ENSG000002732172  
    RAPGEF52  
    2 SIMAP similar genes for RASGEF1B using alignment to 3 protein entries:     RGF1B_HUMAN (see all proteins):
    RASGEF1C    RASGEF1A

    RASGEF1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASGEF1B (see all 861)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931770511,2
    --82347721(+) AGCACA/GAATTA 1 -- ds50010--------
    rs1850403851,2
    --82347778(+) CAGAGC/TGACTA 1 -- ds50010--------
    rs1396020871,2
    --82347815(+) TGAACA/GATTTC 1 -- ds50010--------
    rs1894638231,2
    --82347870(+) TGTTTG/TGTTTA 1 -- ds50010--------
    rs1499037061,2
    C--82347901(+) AACTTA/CTCCAA 1 -- ds50010--------
    rs1449224551,2
    C--82347934(+) AGTTAC/TCAACA 1 -- ds50010--------
    rs1123207091,2
    F--82348503(+) CAAAAG/CAAACG 1 -- ut312Minor allele frequency- C:0.50CSA 4
    rs1147169831,2
    C,F--82348504(+) AAAAGA/GAACGT 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs2010958731,2
    C--82348580(+) AAAAA-/ACACACA 1 -- ut310--------
    rs1490350931,2
    C--82348782(+) AGCTTC/GTGTGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RASGEF1B (82347547 - 82597547 bp, first 250kb of RASGEF1B)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RASGEF1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829985CNV Loss17160897
    nsv4404CNV Loss18451855
    nsv829986CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): RASGEF1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASGEF1B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614532    OMIM disorders: --

    4 diseases for RASGEF1B:    About MalaCards
    myocarditis    short stature    major depressive disorder    malaria


    RASGEF1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): RASGEF1B

    Export disorders for RASGEF1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASGEF1B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with RASGEF1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel mouse gene encoding a Ras-associated guanine nucleotide exchange factor: expression in macrophages and myocarditis elicited by Trypanosoma cruzi parasites. (PubMed id 12488504)1, 2, 3 Ferreira L.R.P.... Gazzinelli R.T. (J. Leukoc. Biol. 2002)
    2. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2- specific nucleotide exchange. (PubMed id 19645719)1, 2 Yaman E.... Tazebay U.H. (FEBS J. 2009)
    3. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PubMed id 23377640)1 (Am J Psychiatry 2013)
    6. Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis. (PubMed id 23894443)2 Telkoparan P....Tazebay U.H. (PLoS ONE 2013)
    7. 8.6Mb interstitial deletion of chromosome 4q13.3q21.23 in a boy with cognitive impairment, short stature, hearing loss, skeletal abnormalities and facial dysmorphism. (PubMed id 22303795)1 Lipska B.S....Limon J. (Genet. Couns. 2011)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 153020 HGNC: 24881 AceView: RASGEF1B Ensembl:ENSG00000138670 euGenes: HUgn153020
    ECgene: RASGEF1B H-InvDB: RASGEF1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RASGEF1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RASGEF1B gene:
    Search GeneIP for patents involving RASGEF1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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