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RASGEF1A Gene

protein-coding   GIFtS: 51
GCID: GC10M043689

RasGEF Domain Family, Member 1A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RasGEF Domain Family, Member 1A1 2
CG48532
CG4853 Gene Product2
Ras-GEF Domain-Containing Family Member 1A2
RASFEF1A5

External Ids:    HGNC: 242461   Entrez Gene: 2210022   Ensembl: ENSG000001989157   OMIM: 6145315   UniProtKB: Q8N9B83   

Export aliases for RASGEF1A gene to outside databases

Previous GC identifers: GC10M042973 GC10M043009 GC10M040217


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RASGEF1A Gene:
RASGEF1A (RasGEF domain family, member 1A) is a protein-coding gene. GO annotations related to this gene include Ras guanyl-nucleotide exchange factor activity. An important paralog of this gene is RAPGEFL1.

UniProtKB/Swiss-Prot: RGF1A_HUMAN, Q8N9B8
Function: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro).
Plays a role in cell migration




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASGEF1A gene promoter:
         STAT5B   GATA-3   Pax-5   HNF-4alpha2   Nkx2-5   LCR-F1   HNF-1A   PPAR-gamma1   HNF-1   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RASGEF1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASGEF1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.21   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.21

RASGEF1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASGEF1A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M043689:  view genomic region     (about GC identifiers)

Start:
43,689,983 bp from pter      End:
43,762,367 bp from pter
Size:
72,385 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RGF1A_HUMAN, Q8N9B8 (See protein sequence)
Recommended Name: Ras-GEF domain-containing family member 1A  
Size: 481 amino acids; 54556 Da
Secondary accessions: Q8TBF1
Alternative splicing: 2 isoforms:  Q8N9B8-1   Q8N9B8-2   

Explore the universe of human proteins at neXtProt for RASGEF1A: NX_Q8N9B8

Explore proteomics data for RASGEF1A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASGEF1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269791.1  NP_660356.2  

    ENSEMBL proteins: 
     ENSP00000363583   ENSP00000379155   ENSP00000379154   ENSP00000363579  

    RASGEF1A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RASGEF1A

     
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    antibodies-online proteins for RASGEF1A (4 products) 

     
    antibodies-online peptides for RASGEF1A

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    antibodies-online antibodies for RASGEF1A (19 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR008937 Ras_GEF
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000651 Ras-like_Gua-exchang_fac_N

    Graphical View of Domain Structure for InterPro Entry Q8N9B8

    ProtoNet protein and cluster: Q8N9B8

    1 Blocks protein domain: IPB001895 Guanine-nucleotide dissociation stimulator CDC25

    UniProtKB/Swiss-Prot: RGF1A_HUMAN, Q8N9B8
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 Ras-GEF domain


    Find genes that share domains with RASGEF1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGF1A_HUMAN, Q8N9B8
    Function: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro).
    Plays a role in cell migration

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005088Ras guanyl-nucleotide exchange factor activity IDA17121879
         
    Find genes that share ontologies with RASGEF1A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RASGEF1A:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RASGEF1A

    miRNA
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    miRTarBase miRNAs that target RASGEF1A:
    hsa-mir-335-5p (MIRT017006)

    Block miRNA regulation of human, mouse, rat RASGEF1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASGEF1A (see all 74):
    hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-605 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidRASGEF1A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    Find genes that share ontologies with RASGEF1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RASGEF1A About    
    See pathways by source

    SuperPathContained pathways About
    1Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    1 BioSystems Pathway for RASGEF1A
        Integrated Breast Cancer Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASGEF1A
    Interactions:

        Search GeneGlobe Interaction Network for RASGEF1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for RASGEF1A (ENSP000003791544) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206292ENSP000003727134STRING: ENSP00000372713
    ENSG00000206308ENSP000003727464STRING: ENSP00000372746
    ENSG00000227317ENSP000004031544STRING: ENSP00000403154
    ENSG00000233890ENSP000003993884STRING: ENSP00000399388
    ENSG00000234258ENSP000003964864STRING: ENSP00000396486
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0016477cell migration IDA17121879
    GO:0032318regulation of Ras GTPase activity IDA17121879
    GO:0046579positive regulation of Ras protein signal transduction IDA17121879
    GO:0051056regulation of small GTPase mediated signal transduction ----

    Find genes that share ontologies with RASGEF1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASGEF1A (RGF1A)

    3 HMDB Compounds for RASGEF1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RASGEF1A gene (2 alternative transcripts): 
    NM_001282862.1  NM_145313.3  

    Unigene Cluster for RASGEF1A:

    RasGEF domain family, member 1A
    Hs.125293  [show with all ESTs]
    Unigene Representative Sequence: AK127432
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374459(uc001jao.1) ENST00000395810(uc001jap.1) ENST00000395809
    ENST00000374455 ENST00000472864
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RASGEF1A (see all 74):
    hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-605 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidRASGEF1A 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK095136.1 AK127432.1 BC022548.1 

    3 DOTS entries:

    DT.100744156  DT.100021634  DT.99931641 

    Selected AceView cDNA sequences (see all 36):

    AK095136 AK127432 BX508269 BU838456 CA415243 AI887949 BM824757 AA324359 
    NM_145313 AA883906 BC022548 BE744303 BX097845 CA943165 Z39259 AI742833 
    CA773172 AI985897 AI203292 BE670730 AI990592 BF338587 BF446578 AI862588 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RASGEF1A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:              -     -                 -                                                                                 
    SP2:                    -                 -                                                                                 
    SP3:                                      -                                                                                 
    SP4:              -     -     -           -                                                                                 
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for RASGEF1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASGEF1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCTGGTCC
    RASGEF1A Expression
    About this image


    RASGEF1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    RASGEF1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASGEF1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125293

    UniProtKB/Swiss-Prot: RGF1A_HUMAN, Q8N9B8
    Tissue specificity: Detected in brain and spinal cord. Highly expressed in a number of intrahepatic
    cholangiocarcinoma tissue biopsies

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASGEF1A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasgef1a1 , 5 RasGEF domain family, member 1A1, 5 89.16(n)1
    93.87(a)1
      6 (55.85 cM)5
    707271  NM_027526.11  NP_081802.11 
     1180663855 
    chicken
    (Gallus gallus)
    Aves RASGEF1A1 RasGEF domain family, member 1A 80.67(n)
    85.24(a)
      423631  XM_004941967.1  XP_004942024.1 
    lizard
    (Anolis carolinensis)
    Reptilia RASGEF1A6
    RasGEF domain family, member 1A
    80(a)
    1 ↔ 1
    GL343233.1(745855-893425)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.244252 Xenopus laevis transcribed sequence with weak similarity more 80.65(n)    CD301594.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73696
    CG48536
    --
    29(a)
    24(a)
    many ↔ many
    many ↔ many
    3L(22734893-22741714)
    2R(13401710-13404950)
    worm
    (Caenorhabditis elegans)
    Secernentea R05G6.106
    Protein R05G6.10 (R05G6.10) mRNA, complete cds
    34(a)
    1 → many
    IV(7517446-7520365) WBGene00019902


    ENSEMBL Gene Tree for RASGEF1A (if available)
    TreeFam Gene Tree for RASGEF1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASGEF1A gene
    RAPGEFL12  RAPGEF22  RAPGEF62  RAPGEF32  RASGEF1C2  RAPGEF42  ENSG000002732172  RASGEF1B2  
    RAPGEF52  
    2 SIMAP similar genes for RASGEF1A using alignment to 2 protein entries:     RGF1A_HUMAN (see all proteins):
    RASGEF1B    RASGEF1C

    Find genes that share paralogs with RASGEF1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASGEF1A (see all 1563)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826802721,2
    --43689616(+) TGCCCC/GCAGAG 1 -- ds50010--------
    rs765030581,2
    C--43689657(+) TCCATA/GCAGCC 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1870487641,2
    --43689679(+) GGTATC/GCTGAA 1 -- ds50010--------
    rs1918993791,2
    --43689764(+) CTGAAC/TGTGCC 1 -- ds50010--------
    rs12549651,2
    C,F,A,H--43689853(+) AGTCTC/TTTGCC 1 -- ds500120Minor allele frequency- T:0.25NS EA NA 2496
    rs1853781441,2
    --43690096(+) CATCAA/CATCAG 1 -- ut310--------
    rs1379801121,2
    C--43690174(+) CACCCA/GTGAAG 1 -- ut310--------
    rs12549661,2
    C,H--43690189(+) CGTGGA/GTGTGT 1 -- ut31 ese314Minor allele frequency- G:0.02MN NA WA CSA EA 560
    rs112384721,2
    C,F--43690253(+) TTTCTC/TATCTC 1 -- ut31 ese34Minor allele frequency- T:0.13NA 126
    rs1421946641,2
    C--43690329(+) TGCAAA/GCACAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RASGEF1A (43689983 - 43762367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for RASGEF1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656730CNV Deletion23128226
    esv2669702CNV Deletion23128226
    nsv466881CNV Loss19166990
    nsv895086CNV Loss21882294
    nsv895085CNV Loss21882294
    nsv895084CNV Loss21882294
    dgv644n71CNV Loss21882294
    nsv825352CNV Gain20364138
    nsv825351CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614531    OMIM disorders: --


    Find genes that share disorders with RASGEF1A           About GenesLikeMe

    Genetic Association Database (GAD): RASGEF1A

    Export disorders for RASGEF1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASGEF1A gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with RASGEF1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease. (PubMed id 19196962)1, 4 Garcia-Barcelo M.M....Tam P.K. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    2. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2- specific nucleotide exchange. (PubMed id 19645719)1, 2 Yaman E.... Tazebay U.H. (FEBS J. 2009)
    3. Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma. (PubMed id 17121879)1, 2 Ura K.... Furukawa Y. (Clin. Cancer Res. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    7. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. (PubMed id 20598377)4 Nischwitz S....Weber F. (J. Neuroimmunol. 2010)
    8. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)
    9. Identifying candidate Hirschsprung disease-associated RET variants. (PubMed id 15759212)1 Burzynski G.M....Hofstra R.M. (Am. J. Hum. Genet. 2005)
    10. A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk. (PubMed id 15829955)1 Emison E.S....Chakravarti A. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221002 HGNC: 24246 AceView: RASGEF1A Ensembl:ENSG00000198915 euGenes: HUgn221002
    ECgene: RASGEF1A H-InvDB: RASGEF1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RASGEF1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RASGEF1A gene:
    Search GeneIP for patents involving RASGEF1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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