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Aliases for RASGEF1A Gene

Aliases for RASGEF1A Gene

  • RasGEF Domain Family, Member 1A 2 3
  • Ras-GEF Domain-Containing Family Member 1A 3
  • CG4853 Gene Product 3
  • RASFEF1A 6
  • CG4853 3

External Ids for RASGEF1A Gene

Previous GeneCards Identifiers for RASGEF1A Gene

  • GC10M042973
  • GC10M043009
  • GC10M043689
  • GC10M040217

Summaries for RASGEF1A Gene

GeneCards Summary for RASGEF1A Gene

RASGEF1A (RasGEF Domain Family, Member 1A) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include Ras guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGEF1B.

UniProtKB/Swiss-Prot for RASGEF1A Gene

  • Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGEF1A Gene

Genomics for RASGEF1A Gene

Regulatory Elements for RASGEF1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASGEF1A Gene

Start:
43,194,533 bp from pter
End:
43,266,919 bp from pter
Size:
72,387 bases
Orientation:
Minus strand

Genomic View for RASGEF1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASGEF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGEF1A Gene

Proteins for RASGEF1A Gene

  • Protein details for RASGEF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9B8-RGF1A_HUMAN
    Recommended name:
    Ras-GEF domain-containing family member 1A
    Protein Accession:
    Q8N9B8
    Secondary Accessions:
    • Q8TBF1

    Protein attributes for RASGEF1A Gene

    Size:
    481 amino acids
    Molecular mass:
    54556 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RASGEF1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASGEF1A Gene

Proteomics data for RASGEF1A Gene at MOPED

Post-translational modifications for RASGEF1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASGEF1A Gene

No data available for DME Specific Peptides for RASGEF1A Gene

Domains for RASGEF1A Gene

Suggested Antigen Peptide Sequences for RASGEF1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9B8

UniProtKB/Swiss-Prot:

RGF1A_HUMAN :
  • Q8N9B8
Domain:
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RASGEF1A: view

No data available for Gene Families for RASGEF1A Gene

Function for RASGEF1A Gene

Molecular function for RASGEF1A Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration.

Gene Ontology (GO) - Molecular Function for RASGEF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity --
GO:0005088 Ras guanyl-nucleotide exchange factor activity IDA 17121879
genes like me logo Genes that share ontologies with RASGEF1A: view

Phenotypes for RASGEF1A Gene

GenomeRNAi human phenotypes for RASGEF1A:
genes like me logo Genes that share phenotypes with RASGEF1A: view

Animal Model Products

CRISPR Products

miRNA for RASGEF1A Gene

miRTarBase miRNAs that target RASGEF1A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASGEF1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RASGEF1A Gene

Localization for RASGEF1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASGEF1A Gene COMPARTMENTS Subcellular localization image for RASGEF1A gene
Compartment Confidence
cytosol 3
extracellular 2
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RASGEF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with RASGEF1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASGEF1A Gene

Pathways for RASGEF1A Gene

genes like me logo Genes that share pathways with RASGEF1A: view

Pathways by source for RASGEF1A Gene

1 BioSystems pathway for RASGEF1A Gene

Interacting Proteins for RASGEF1A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000379154%0d%0a9606.ENSP00000044462%0d%0a9606.ENSP00000369411%0d%0a
Selected Interacting proteins: ENSP00000379154 for RASGEF1A Gene via STRING

Gene Ontology (GO) - Biological Process for RASGEF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0016477 cell migration IDA 17121879
GO:0043547 positive regulation of GTPase activity IEA --
GO:0046579 positive regulation of Ras protein signal transduction IDA 17121879
GO:0051056 regulation of small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RASGEF1A: view

Compounds for RASGEF1A Gene

(3) HMDB Compounds for RASGEF1A Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RASGEF1A: view

Transcripts for RASGEF1A Gene

Unigene Clusters for RASGEF1A Gene

RasGEF domain family, member 1A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASGEF1A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RASGEF1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGEF1A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for RASGEF1A Gene

GeneLoc Exon Structure for
RASGEF1A
ECgene alternative splicing isoforms for
RASGEF1A

Expression for RASGEF1A Gene

mRNA expression in normal human tissues for RASGEF1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGEF1A Gene

This gene is overexpressed in Brain - Cortex (4.6) and Brain - Nucleus accumbens (basal ganglia) (4.0).

SOURCE GeneReport for Unigene cluster for RASGEF1A Gene Hs.125293

mRNA Expression by UniProt/SwissProt for RASGEF1A Gene

Q8N9B8-RGF1A_HUMAN
Tissue specificity: Detected in brain and spinal cord. Highly expressed in a number of intrahepatic cholangiocarcinoma tissue biopsies.
genes like me logo Genes that share expressions with RASGEF1A: view

In Situ Assay Products

No data available for Protein expression for RASGEF1A Gene

Orthologs for RASGEF1A Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGEF1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASGEF1A 35
  • 99.52 (n)
  • 99.59 (a)
RASGEF1A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASGEF1A 35
  • 91.46 (n)
  • 95.96 (a)
RASGEF1A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASGEF1A 35
  • 90.92 (n)
  • 94.47 (a)
RASGEF1A 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasgef1a 35
  • 89.16 (n)
  • 93.87 (a)
Rasgef1a 16
Rasgef1a 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASGEF1A 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASGEF1A 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasgef1a 35
  • 88.82 (n)
  • 93.05 (a)
chicken
(Gallus gallus)
Aves RASGEF1A 35
  • 80.67 (n)
  • 85.24 (a)
RASGEF1A 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASGEF1A 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24425 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rasgef1a 35
  • 74.56 (n)
  • 79.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4853 36
  • 24 (a)
ManyToMany
CG7369 36
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R05G6.10 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for RASGEF1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RASGEF1A Gene

ENSEMBL:
Gene Tree for RASGEF1A (if available)
TreeFam:
Gene Tree for RASGEF1A (if available)

Paralogs for RASGEF1A Gene

Selected SIMAP similar genes for RASGEF1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASGEF1A: view

Variants for RASGEF1A Gene

Sequence variations from dbSNP and Humsavar for RASGEF1A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs868314 -- 43,257,196(+) CAGCA(A/G)GAGGG intron-variant
rs869184 -- 43,263,007(+) GAACC(A/C/G/T)GGGGC intron-variant
rs871763 -- 43,238,740(-) CACAT(A/G)CCCTA intron-variant
rs952641 -- 43,263,276(+) CAGTG(A/G)ACATC intron-variant
rs953999 -- 43,263,202(+) TTTGA(A/C/G/T)TGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASGEF1A Gene

Variant ID Type Subtype PubMed ID
dgv644n71 CNV Loss 21882294
nsv895084 CNV Loss 21882294
nsv466881 CNV Loss 19166990
nsv895085 CNV Loss 21882294
esv2656730 CNV Deletion 23128226
nsv825351 CNV Gain 20364138
nsv825352 CNV Gain 20364138
nsv895086 CNV Loss 21882294
esv2669702 CNV Deletion 23128226

Relevant External Links for RASGEF1A Gene

HapMap Linkage Disequilibrium report
RASGEF1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGEF1A Gene

Disorders for RASGEF1A Gene

Relevant External Links for RASGEF1A

Genetic Association Database (GAD)
RASGEF1A
genes like me logo Genes that share disorders with RASGEF1A: view

No data available for UniProtKB/Swiss-Prot for RASGEF1A Gene

Publications for RASGEF1A Gene

  1. Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma. (PMID: 17121879) Ura K. … Furukawa Y. (Clin. Cancer Res. 2006) 3 4
  2. Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease. (PMID: 19196962) Garcia-Barcelo M.M. … Tam P.K. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 48
  3. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2- specific nucleotide exchange. (PMID: 19645719) Yaman E. … Tazebay U.H. (FEBS J. 2009) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for RASGEF1A Gene

Sources for RASGEF1A Gene

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