Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RASEF Gene

Aliases for RASEF Gene

  • RAS And EF-Hand Domain Containing 2 3 5
  • Ras-Related Protein Rab-45 3 4
  • RAB45 3 4
  • RAB45, Member RAS Oncogene Family 2

External Ids for RASEF Gene

Previous HGNC Symbols for RASEF Gene

  • RAB45

Previous GeneCards Identifiers for RASEF Gene

  • GC09M081055
  • GC09M082826
  • GC09M084784
  • GC09M085594
  • GC09M055422
  • GC09M083086
  • GC09M083230

Summaries for RASEF Gene

Entrez Gene Summary for RASEF Gene

  • This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential role as tumor suppressor has been indicated for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for RASEF Gene

RASEF (RAS And EF-Hand Domain Containing) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RAB44.

UniProtKB/Swiss-Prot for RASEF Gene

  • Binds predominantly GDP, and also GTP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASEF Gene

Genomics for RASEF Gene

Regulatory Elements for RASEF Gene

Enhancers for RASEF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RASEF on UCSC Golden Path with GeneCards custom track

Promoters for RASEF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASEF on UCSC Golden Path with GeneCards custom track

Genomic Location for RASEF Gene

82,979,585 bp from pter
83,063,177 bp from pter
83,593 bases
Minus strand

Genomic View for RASEF Gene

Genes around RASEF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASEF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASEF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASEF Gene

Proteins for RASEF Gene

  • Protein details for RASEF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras and EF-hand domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • A6NC29
    • Q96N04

    Protein attributes for RASEF Gene

    740 amino acids
    Molecular mass:
    82879 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for RASEF Gene

    Alternative splice isoforms for RASEF Gene


neXtProt entry for RASEF Gene

Proteomics data for RASEF Gene at MOPED

Post-translational modifications for RASEF Gene

  • Ubiquitination at Lys 171, Lys 366, and Lys 388
  • Modification sites at PhosphoSitePlus

Other Protein References for RASEF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RASEF

No data available for DME Specific Peptides for RASEF Gene

Domains & Families for RASEF Gene

Suggested Antigen Peptide Sequences for RASEF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Belongs to the small GTPase superfamily. Rab family.
  • Contains 2 EF-hand domains.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RASEF: view

Function for RASEF Gene

Molecular function for RASEF Gene

UniProtKB/Swiss-Prot Function:
Binds predominantly GDP, and also GTP.
genes like me logo Genes that share phenotypes with RASEF: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASEF Gene

Localization for RASEF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASEF Gene

Cytoplasm, perinuclear region.

Subcellular locations from

Jensen Localization Image for RASEF Gene COMPARTMENTS Subcellular localization image for RASEF gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for RASEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with RASEF: view

Pathways & Interactions for RASEF Gene

SuperPathways for RASEF Gene

No Data Available

Interacting Proteins for RASEF Gene

Gene Ontology (GO) - Biological Process for RASEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RASEF: view

No data available for Pathways by source and SIGNOR curated interactions for RASEF Gene

Drugs & Compounds for RASEF Gene

(1) Drugs for RASEF Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RASEF: view

Transcripts for RASEF Gene

mRNA/cDNA for RASEF Gene

Unigene Clusters for RASEF Gene

RAS and EF-hand domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASEF Gene

No ASD Table

Relevant External Links for RASEF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASEF Gene

mRNA expression in normal human tissues for RASEF Gene

mRNA differential expression in normal tissues according to GTEx for RASEF Gene

This gene is overexpressed in Pancreas (x9.5), Minor Salivary Gland (x5.7), Colon - Transverse (x4.6), Thyroid (x4.6), and Stomach (x4.5).

Protein differential expression in normal tissues from HIPED for RASEF Gene

This gene is overexpressed in Brain (43.1), Adipocyte (12.8), and Urine (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASEF Gene

SOURCE GeneReport for Unigene cluster for RASEF Gene Hs.129136

mRNA Expression by UniProt/SwissProt for RASEF Gene

Tissue specificity: Down-regulated in cutaneous melanoma cells but not in breast cancer cells.
genes like me logo Genes that share expression patterns with RASEF: view

Protein tissue co-expression partners for RASEF Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RASEF Gene

Orthologs for RASEF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASEF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASEF 35
  • 88.33 (n)
  • 89.46 (a)
  • 89 (a)
(Canis familiaris)
Mammalia RASEF 35
  • 88.02 (n)
  • 89.78 (a)
  • 79 (a)
(Mus musculus)
Mammalia Rasef 35
  • 82.84 (n)
  • 82.95 (a)
Rasef 16
Rasef 36
  • 81 (a)
(Pan troglodytes)
Mammalia RASEF 35
  • 99.32 (n)
  • 99.05 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rasef 35
  • 81.29 (n)
  • 78.84 (a)
(Monodelphis domestica)
Mammalia RASEF 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia RASEF 36
  • 72 (a)
(Gallus gallus)
Aves RASEF 35
  • 74.65 (n)
  • 74.51 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia RASEF 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC147600 35
  • 68.7 (n)
  • 70.25 (a)
Str.6533 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4418 35
(Danio rerio)
Actinopterygii rasef 35
  • 60.08 (n)
  • 56.52 (a)
rasef 36
  • 53 (a)
(Caenorhabditis elegans)
Secernentea tag-312 35
  • 46.72 (n)
  • 36.13 (a)
tag-312 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT10 36
  • 27 (a)
YPT52 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for RASEF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASEF Gene

Gene Tree for RASEF (if available)
Gene Tree for RASEF (if available)

Paralogs for RASEF Gene

Paralogs for RASEF Gene

genes like me logo Genes that share paralogs with RASEF: view

Variants for RASEF Gene

Sequence variations from dbSNP and Humsavar for RASEF Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs4146960 - 83,012,493(+) TACGC(A/G)TTTTG reference, missense
rs952450 -- 83,005,093(-) AGAAT(A/G)GGAGC intron-variant
rs998119 -- 83,001,897(+) GGAGA(C/T)GTTTC intron-variant
rs1008171 -- 82,991,121(+) CCCCC(A/C)CTCAC intron-variant
rs1010480 -- 83,030,968(-) CACTT(C/T)GGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASEF Gene

Variant ID Type Subtype PubMed ID
nsv893511 CNV Gain 21882294
nsv6585 CNV Loss 18451855
esv2661414 CNV Deletion 23128226
nsv436616 CNV Deletion 17901297

Variation tolerance for RASEF Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RASEF Gene

Disorders for RASEF Gene

Relevant External Links for RASEF

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RASEF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASEF Gene

Publications for RASEF Gene

  1. Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase. (PMID: 17448446) Shintani M. … Katada T. (Biochem. Biophys. Res. Commun. 2007) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma. (PMID: 24703243) Kaplon J. … Peeper D.S. (Pigment Cell Melanoma Res 2014) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells. (PMID: 21890458) Nakamura S. … Ohnishi K. (Carcinogenesis 2011) 3

Products for RASEF Gene

Sources for RASEF Gene