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Aliases for RASEF Gene

Aliases for RASEF Gene

  • RAS And EF-Hand Domain Containing 2 3
  • Ras-Related Protein Rab-45 3 4
  • RAB45 3 4
  • Ras And EF-Hand Domain-Containing Protein 3
  • RAB45, Member RAS Oncogene Family 2

External Ids for RASEF Gene

Previous HGNC Symbols for RASEF Gene

  • RAB45

Previous GeneCards Identifiers for RASEF Gene

  • GC09M081055
  • GC09M082826
  • GC09M084784
  • GC09M085594
  • GC09M055422

Summaries for RASEF Gene

Entrez Gene Summary for RASEF Gene

  • This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential role as tumor suppressor has been indicated for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for RASEF Gene

RASEF (RAS And EF-Hand Domain Containing) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and GTP binding. An important paralog of this gene is RAB27B.

UniProtKB/Swiss-Prot for RASEF Gene

  • Binds predominantly GDP, and also GTP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASEF Gene

Genomics for RASEF Gene

Genomic Location for RASEF Gene

Start:
82,979,585 bp from pter
End:
83,063,177 bp from pter
Size:
83,593 bases
Orientation:
Minus strand

Genomic View for RASEF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASEF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASEF Gene

Proteins for RASEF Gene

  • Protein details for RASEF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ41-RASEF_HUMAN
    Recommended name:
    Ras and EF-hand domain-containing protein
    Protein Accession:
    Q8IZ41
    Secondary Accessions:
    • A6NC29
    • Q96N04

    Protein attributes for RASEF Gene

    Size:
    740 amino acids
    Molecular mass:
    82879 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for RASEF Gene

    Alternative splice isoforms for RASEF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASEF Gene

Proteomics data for RASEF Gene at MOPED

Post-translational modifications for RASEF Gene

  • Ubiquitination at Lys171, Lys366, and Lys388
  • Modification sites at PhosphoSitePlus

Other Protein References for RASEF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASEF Gene

Domains for RASEF Gene

Gene Families for RASEF Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RASEF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZ41

UniProtKB/Swiss-Prot:

RASEF_HUMAN :
  • Q8IZ41
Domain:
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RASEF: view

Function for RASEF Gene

Molecular function for RASEF Gene

UniProtKB/Swiss-Prot Function: Binds predominantly GDP, and also GTP.

Gene Ontology (GO) - Molecular Function for RASEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005509 calcium ion binding IEA --
GO:0005525 GTP binding IEA --
GO:0051015 actin filament binding --
genes like me logo Genes that share ontologies with RASEF: view
genes like me logo Genes that share phenotypes with RASEF: view

miRNA for RASEF Gene

miRTarBase miRNAs that target RASEF

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RASEF Gene

Localization for RASEF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASEF Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASEF Gene COMPARTMENTS Subcellular localization image for RASEF gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RASEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with RASEF: view

Pathways for RASEF Gene

SuperPathways for RASEF Gene

No Data Available

Interacting Proteins for RASEF Gene

Gene Ontology (GO) - Biological Process for RASEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006904 NOT vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007155 cell adhesion --
genes like me logo Genes that share ontologies with RASEF: view

No data available for Pathways by source for RASEF Gene

Compounds for RASEF Gene

(1) HMDB Compounds for RASEF Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RASEF: view

Transcripts for RASEF Gene

mRNA/cDNA for RASEF Gene

Unigene Clusters for RASEF Gene

RAS and EF-hand domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASEF Gene

No ASD Table

Relevant External Links for RASEF Gene

GeneLoc Exon Structure for
RASEF
ECgene alternative splicing isoforms for
RASEF

Expression for RASEF Gene

mRNA expression in normal human tissues for RASEF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASEF Gene

This gene is overexpressed in Pancreas (9.5), Minor Salivary Gland (5.7), Colon - Transverse (4.6), Thyroid (4.6), and Stomach (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASEF Gene

SOURCE GeneReport for Unigene cluster for RASEF Gene Hs.129136

mRNA Expression by UniProt/SwissProt for RASEF Gene

Q8IZ41-RASEF_HUMAN
Tissue specificity: Down-regulated in cutaneous melanoma cells but not in breast cancer cells.
genes like me logo Genes that share expressions with RASEF: view

Orthologs for RASEF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASEF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASEF 35
  • 99.32 (n)
  • 99.05 (a)
RASEF 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASEF 35
  • 88.33 (n)
  • 89.46 (a)
RASEF 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASEF 35
  • 88.02 (n)
  • 89.78 (a)
RASEF 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasef 35
  • 82.84 (n)
  • 82.95 (a)
Rasef 16
Rasef 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASEF 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASEF 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasef 35
  • 81.29 (n)
  • 78.84 (a)
chicken
(Gallus gallus)
Aves RASEF 35
  • 74.65 (n)
  • 74.51 (a)
RASEF 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASEF 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4418 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC147600 35
  • 68.7 (n)
  • 70.25 (a)
Str.6533 35
zebrafish
(Danio rerio)
Actinopterygii rasef 35
  • 60.08 (n)
  • 56.52 (a)
rasef 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-312 35
  • 46.72 (n)
  • 36.13 (a)
tag-312 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT10 36
  • 27 (a)
ManyToMany
YPT52 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for RASEF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASEF Gene

ENSEMBL:
Gene Tree for RASEF (if available)
TreeFam:
Gene Tree for RASEF (if available)

Paralogs for RASEF Gene

Paralogs for RASEF Gene

genes like me logo Genes that share paralogs with RASEF: view

Variants for RASEF Gene

Sequence variations from dbSNP and Humsavar for RASEF Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs952450 -- 83,005,093(-) AGAAT(A/G)GGAGC intron-variant
rs998119 -- 83,001,897(+) GGAGA(C/T)GTTTC intron-variant
rs1008171 -- 82,991,121(+) CCCCC(A/C)CTCAC intron-variant
rs1010480 -- 83,030,968(-) CACTT(C/T)GGTGA intron-variant
rs1125752 -- 83,034,787(-) GAGTC(A/G)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASEF Gene

Variant ID Type Subtype PubMed ID
nsv893511 CNV Gain 21882294
nsv6585 CNV Loss 18451855
esv2661414 CNV Deletion 23128226
nsv436616 CNV Deletion 17901297

Relevant External Links for RASEF Gene

HapMap Linkage Disequilibrium report
RASEF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASEF Gene

Disorders for RASEF Gene

Relevant External Links for RASEF

Genetic Association Database (GAD)
RASEF
genes like me logo Genes that share disorders with RASEF: view

No data available for UniProtKB/Swiss-Prot for RASEF Gene

Publications for RASEF Gene

  1. Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase. (PMID: 17448446) Shintani M. … Katada T. (Biochem. Biophys. Res. Commun. 2007) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Epigenetic regulation identifies RASEF as a tumor-suppressor gene in uveal melanoma. (PMID: 18385040) Maat W. … van der Velden P.A. (Invest. Ophthalmol. Vis. Sci. 2008) 3

Products for RASEF Gene

Sources for RASEF Gene

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