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RASEF Gene

protein-coding   GIFtS: 51
GCID: GC09M085594

RAS And EF-Hand Domain Containing

(Previous names: RAB45, member RAS oncogene family)
(Previous symbol: RAB45)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAS And EF-Hand Domain Containing1 2
RAB451 2 3
Ras-Related Protein Rab-452 3
RAB45, Member RAS Oncogene Family1
Ras And EF-Hand Domain-Containing Protein2

External Ids:    HGNC: 264641   Entrez Gene: 1581582   Ensembl: ENSG000001651057   OMIM: 6113445   UniProtKB: Q8IZ413   

Export aliases for RASEF gene to outside databases

Previous GC identifers: GC09M081055 GC09M082826 GC09M084784 GC09M055422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RASEF Gene:
This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The
encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A
potential role as tumor suppressor has been indicated for this gene. (provided by RefSeq, Nov 2012)

GeneCards Summary for RASEF Gene:
RASEF (RAS and EF-hand domain containing) is a protein-coding gene. GO annotations related to this gene include GTP binding and calcium ion binding. An important paralog of this gene is RAB27A.

UniProtKB/Swiss-Prot: RASEF_HUMAN, Q8IZ41
Function: Binds predominantly GDP, and also GTP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASEF gene promoter:
         LHX3b/Lhx3b   SREBP-1c   Cdc5   SREBP-1b   Arnt   HEN1   PPAR-gamma1   SREBP-1a   LHX3a/Lhx3a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASEF promoter sequence
   Search Chromatin IP Primers for RASEF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASEF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.32   Ensembl cytogenetic band:  9q21.32   HGNC cytogenetic band: 9q21.33

RASEF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASEF gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M085594:  view genomic region     (about GC identifiers)

Start:
85,594,500 bp from pter      End:
85,678,092 bp from pter
Size:
83,593 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RASEF_HUMAN, Q8IZ41 (See protein sequence)
Recommended Name: Ras and EF-hand domain-containing protein  
Size: 740 amino acids; 82879 Da
Subunit: Homodimer
2 PDB 3D structures from and Proteopedia for RASEF:
2P5S (3D)        2PMY (3D)    
Secondary accessions: A6NC29 Q96N04
Alternative splicing: 2 isoforms:  Q8IZ41-1   Q8IZ41-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RASEF: NX_Q8IZ41

Explore proteomics data for RASEF at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys171, Lys366, Lys388
  • Modification sites at PhosphoSitePlus

  • See RASEF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689786.2  
    ENSEMBL proteins: 
     ENSP00000365630   ENSP00000345651  

    RASEF Human Recombinant Protein Products:

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    antibodies-online proteins for RASEF (3 products) 

     
    antibodies-online peptides for RASEF

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene
    EFHAND: EF-hand domain containing

    Selected InterPro protein domains (see all 7):
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry Q8IZ41

    ProtoNet protein and cluster: Q8IZ41

    4 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RASEF_HUMAN, Q8IZ41
    Similarity: Belongs to the small GTPase superfamily. Rab family
    Similarity: Contains 2 EF-hand domains


    Find genes that share domains with RASEF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASEF_HUMAN, Q8IZ41
    Function: Binds predominantly GDP, and also GTP

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005198structural molecule activity ----
    GO:0005509calcium ion binding IEA--
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RASEF           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RASEF:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RASEF

    miRNA
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    hsa-mir-21-5p (MIRT030764)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RASEF_HUMAN, Q8IZ41: Cytoplasm, perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0015629actin cytoskeleton ----
    GO:0016020membrane ----
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with RASEF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASEF
    Interactions:

        Search GeneGlobe Interaction Network for RASEF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for RASEF (ENSP000003656304) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC2ENSP000002304494STRING: ENSP00000230449
    EXOC4ENSP000002538614STRING: ENSP00000253861
    EXOC7ENSP000003341004STRING: ENSP00000334100
    EXOC6ENSP000002607624STRING: ENSP00000260762
    EXOC6BENSP000002724274STRING: ENSP00000272427
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007155cell adhesion ----
    GO:0007165signal transduction ----

    Find genes that share ontologies with RASEF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASEF

    1 HMDB Compound for RASEF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RASEF gene: 
    NM_152573.3  

    Unigene Cluster for RASEF:

    RAS and EF-hand domain containing
    Hs.129136  [show with all ESTs]
    Unigene Representative Sequence: NM_152573
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376447(uc004amo.1) ENST00000340717(uc004amp.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat RASEF

    Additional mRNA sequence: 

    AK056176.1 AK056882.1 AK290986.1 BC023566.1 

    6 DOTS entries:

    DT.95342572  DT.209561  DT.95155283  DT.95364767  DT.121154818  DT.95343689 

    Selected AceView cDNA sequences (see all 68):

    BM856433 BX103248 AA601537 AI915961 BE302954 BU859847 BE463583 BM982321 
    BE303010 AK056882 AA826324 BC023566 AI890787 AA775044 NM_152573 BG574207 
    AA976604 BE384120 CB113169 AI738861 BM786593 BQ229028 BG334589 BX479058 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASEF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RASEF Expression
    About this image


    RASEF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    RASEF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASEF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129136

    UniProtKB/Swiss-Prot: RASEF_HUMAN, Q8IZ41
    Tissue specificity: Down-regulated in cutaneous melanoma cells but not in breast cancer cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RASEF gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasef1 , 5 RAS and EF hand domain containing1, 5 82.84(n)1
    82.95(a)1
      4 (36.06 cM)5
    2425051  NM_001017427.11  NP_001017427.11 
     737145795 
    chicken
    (Gallus gallus)
    Aves RASEF1 RAS and EF-hand domain containing 74.65(n)
    74.51(a)
      427451  XM_003643027.2  XP_003643075.2 
    lizard
    (Anolis carolinensis)
    Reptilia RASEF6
    RAS and EF-hand domain containing
    73(a)
    1 ↔ 1
    2(42954126-43001958)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.44182 Xenopus laevis transcribed sequence with weak similarity more 76.86(n)    48059247 
    zebrafish
    (Danio rerio)
    Actinopterygii rasef1 RAS and EF-hand domain containing 60.08(n)
    56.52(a)
      570731  XM_694243.5  XP_699335.4 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-3121 tag-312 46.72(n)
    36.13(a)
      180593  NM_076122.3  NP_508523.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT526
    YPT106
    Rab family GTPase, similar to Ypt51p and Ypt53p an...
    Rab family GTP-binding protein that contains the P...
    27(a)
    27(a)
    many ↔ many
    many ↔ many
    XI(465367-466071) YKR014C
    II(737770-738369) YBR264C


    ENSEMBL Gene Tree for RASEF (if available)
    TreeFam Gene Tree for RASEF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASEF gene
    RAB27A2  RAB442  RAB27B2  
    Selected SIMAP similar genes for RASEF using alignment to 2 protein entries:     RASEF_HUMAN (see all proteins) (see all similar genes):
    RAB5B    RAB43    RANP1    RAB8A    RAB15    RAB37
    RAB8B    RAB19    RAB2B    RAB13    RAB18    RAB1A
    RAB2A    RAB30    RAB3A    RAB17    RAB14    RAB1B

    Find genes that share paralogs with RASEF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASEF (see all 1737)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105683231,2
    C--55486885(+) TGATC-/AAAGATA 1 -- int11Minor allele frequency- AA:0.00NA 2
    rs1858137731,2
    --85594036(+) GAGGCA/GGCAGT 1 -- ds50010--------
    rs757029181,2
    --85594063(+) GGACAC/TGGGGC 1 -- ds50010--------
    rs1181815241,2
    F--85594235(+) ATGTGC/TGGATG 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs734675161,2
    C,F--85594236(+) TGTGCG/AGATGG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs764659981,2
    C,F--85594363(+) CCAGGC/TGTGCA 1 -- ds50011Minor allele frequency- T:0.08EA 120
    rs788064781,2
    C--85594558(+) AGTTCA/CTTAGA 1 -- ut310--------
    rs736510201,2
    C,F--85594621(+) AGAGAA/TATAAA 1 -- ut312Minor allele frequency- T:0.20WA 120
    rs736510211,2
    C--85594626(+) AATAAA/CCAGTA 1 -- ut312Minor allele frequency- C:0.20WA 120
    rs1887264411,2
    --85594724(+) ATATAC/TACATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RASEF (85594500 - 85678092 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RASEF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436616CNV Deletion17901297
    esv2661414CNV Deletion23128226
    nsv6585CNV Loss18451855
    nsv893511CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611344    OMIM disorders: --


    Find genes that share disorders with RASEF           About GenesLikeMe

    Genetic Association Database (GAD): RASEF

    Export disorders for RASEF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASEF gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with RASEF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase. (PubMed id 17448446)1, 2 Shintani M.... Katada T. (Biochem. Biophys. Res. Commun. 2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    5. Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells. (PubMed id 21890458)1 Nakamura S....Ohnishi K. (Carcinogenesis 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Epigenetic regulation identifies RASEF as a tumor-suppressor gene in uveal melanoma. (PubMed id 18385040)1 Maat W....van der Velden P.A. (amp 2008)
    9. Mapping of a novel ocular and cutaneous malignant melanoma susceptibility locus to chromosome 9q21.32. (PubMed id 16174859)2 Joensson G.... Borg A. (J. Natl. Cancer Inst. 2005)
    10. Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia. (PubMed id 16015647)2 Sweetser D.A.... Daly S.B. (Genes Chromosomes Cancer 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 158158 HGNC: 26464 AceView: RASEF Ensembl:ENSG00000165105 euGenes: HUgn158158
    ECgene: RASEF H-InvDB: RASEF

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RASEF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASEF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RASEF gene:
    Search GeneIP for patents involving RASEF

    GeneCards and IP:
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