Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RASD2 Gene

protein-coding   GIFtS: 54
GCID: GC22P035936

RASD Family, Member 2

  Search for RASD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RASD Family, Member 21 2     MGC:48342
Ras Homolog Enriched In Striatum1 2 3     Rhes2
Tumor Endothelial Marker 21 2 3     GTP-Binding Protein Rhes2
TEM22 3 5     RHES5

External Ids:    HGNC: 182291   Entrez Gene: 235512   Ensembl: ENSG000001003027   OMIM: 6128425   UniProtKB: Q96D213   

Export aliases for RASD2 gene to outside databases

Previous GC identifers: GC22P032586 GC22P034209 GC22P034261 GC22P018896


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RASD2 Gene:
This gene encodes a Ras-related protein that enriched in striatum. The product of this gene binds to GTP and
possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function
of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal
transduction cascades. (provided by RefSeq, Jul 2008)

GeneCards Summary for RASD2 Gene:
RASD2 (RASD family, member 2) is a protein-coding gene. GO annotations related to this gene include phosphatidylinositol 3-kinase binding and GTP binding. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RHES_HUMAN, Q96D21
Function: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving
G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected
striatal competencies, mainly locomotor activity and motor coordination

Gene Wiki entry for RASD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASD2 gene promoter:
         Oct-B1   RFX1   oct-B2   E47   Egr-4   AREB6   PPAR-alpha   POU2F1   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASD2 promoter sequence
   Search Chromatin IP Primers for RASD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

RASD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASD2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P035936:  view genomic region     (about GC identifiers)

Start:
35,936,915 bp from pter      End:
35,950,048 bp from pter
Size:
13,134 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RHES_HUMAN, Q96D21 (See protein sequence)
Recommended Name: GTP-binding protein Rhes precursor  
Size: 266 amino acids; 30366 Da
Subunit: Monomer (Potential). Interacts with PIK3CA and UBE2I (By similarity). Interacts with GNB1, GNB2 and GNB3.
Interacts with HTT; interacts with mutant HTT (mHTT) with a much higher affinity than wild type HTT
Miscellaneous: Reduces cell survival in striatal cells with Huntington disease by binding to mutant Huntington
disease protein (mHTT; poly-Gln region with 82 repeats) and inducing sumoylation of mHTT
Sequence caution: Sequence=AAG00868.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O95520 Q5THY8

Explore the universe of human proteins at neXtProt for RASD2: NX_Q96D21

Explore proteomics data for RASD2 at MOPED

Post-translational modifications: 

  • Farnesylated. Farnesylation is required for membrane targeting (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055125.2  
    ENSEMBL proteins: 
     ENSP00000216127  

    RASD2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RASD2
    OriGene Protein Over-expression Lysate for RASD2
    OriGene MassSpec for RASD2
    OriGene Custom Protein Services for RASD2
    GenScript Custom Purified and Recombinant Proteins Services for RASD2
    Novus Biologicals RASD2 Proteins
    Novus Biologicals RASD2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RASD2

     
    Search eBioscience for Proteins for RASD2 

    RASD2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RASD2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RASD2
    OriGene Custom Antibody Services for RASD2
    Novus Biologicals RASD2 Antibodies
    Abcam antibodies for RASD2
    Cloud-Clone Corp. Antibodies for RASD2
    ThermoFisher Antibodies for RASD2
    LSBio Antibodies in human, mouse, rat for RASD2

    RASD2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RASD2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RASD2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RASD2
    Cloud-Clone Corp. CLIAs for RASD2
    Search eBioscience for ELISAs for RASD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q96D21

    ProtoNet protein and cluster: Q96D21

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RHES_HUMAN, Q96D21
    Similarity: Belongs to the small GTPase superfamily. RasD family


    Find genes that share domains with RASD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHES_HUMAN, Q96D21
    Function: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving
    G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected
    striatal competencies, mainly locomotor activity and motor coordination

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS11976265
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
    GO:0031624ubiquitin conjugating enzyme binding IEA--
    GO:0031681G-protein beta-subunit binding IPI19255495
         
    Find genes that share ontologies with RASD2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RASD2:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rasd2):
     behavior/neurological  growth/size/body 

    Find genes that share phenotypes with RASD2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rasd2tm1Rdl for RASD2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RASD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASD2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RASD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASD2 (see all 12):
    hsa-miR-495 hsa-miR-631 hsa-miR-3661 hsa-miR-9 hsa-miR-124 hsa-miR-144 hsa-miR-582-5p hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidRASD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RASD2
    Predesigned siRNA for gene silencing in human, mouse, rat RASD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RASD2

    Clone
    Products:
         
    OriGene clones in human, mouse for RASD2 (see all 7)
    OriGene ORF clones in mouse, rat for RASD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RASD2 (NM_014310)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASD2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RASD2
    Browse ESI BIO Cell Lines and PureStem Progenitors for RASD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RHES_HUMAN, Q96D21: Cell membrane; Lipid-anchor (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    mitochondrion3
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane ISS--
    GO:0016020membrane ----

    Find genes that share ontologies with RASD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASD2
    Interactions:

        Search GeneGlobe Interaction Network for RASD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for RASD2 (Q96D213 ENSP000002161274) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    SMAD2Q157963, ENSP000002621604I2D: score=3 STRING: ENSP00000262160
    SMAD3P840223, ENSP000003329734I2D: score=3 STRING: ENSP00000332973
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    PIK3CAP423363, ENSP000002639674I2D: score=2 STRING: ENSP00000263967
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic IEA--
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----

    Find genes that share ontologies with RASD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASD2 (RHES)

    1 HMDB Compound for RASD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RASD2 gene: 
    NM_014310.3  

    Unigene Cluster for RASD2:

    RASD family, member 2
    Hs.474711  [show with all ESTs]
    Unigene Representative Sequence: BC013419
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000216127(uc003anx.3 uc003any.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RASD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASD2 (see all 12):
    hsa-miR-495 hsa-miR-631 hsa-miR-3661 hsa-miR-9 hsa-miR-124 hsa-miR-144 hsa-miR-582-5p hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidRASD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RASD2
    Predesigned siRNA for gene silencing in human, mouse, rat RASD2
    Clone
    Products:
         
    OriGene clones in human, mouse for RASD2 (see all 7)
    OriGene ORF clones in mouse, rat for RASD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RASD2 (NM_014310)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASD2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RASD2
    OriGene qSTAR qPCR primer pairs in human, mouse for RASD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASD2
      QuantiTect SYBR Green Assays in human, mouse, rat RASD2
      QuantiFast Probe-based Assays in human, mouse, rat RASD2

    Additional mRNA sequence: 

    AF279143.1 AL831936.1 BC013419.2 CR456477.1 

    1 DOTS entry:

    DT.100027076 

    Selected AceView cDNA sequences (see all 73):

    BX090908 BQ073742 BQ017479 AF279143 BQ954076 BC013419 CR456477 NM_014310 
    BQ947936 BU584208 BI754083 BG119387 BU585007 BU585114 BU584901 R56247 
    BU584605 BF970943 BX332736 H55531 BU585099 BE275652 BU584604 BE047733 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RASD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTCCGTG
    RASD2 Expression
    About this image


    RASD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Brain (Nervous System)
             Striatum
    RASD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474711

    UniProtKB/Swiss-Prot: RHES_HUMAN, Q96D21
    Tissue specificity: Pancreatic endocrine cells (islets of Langerhans)

        Custom PCR Arrays for RASD2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RASD2
    OriGene qSTAR qPCR primer pairs in human, mouse for RASD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASD2
    QuantiTect SYBR Green Assays in human, mouse, rat RASD2
    QuantiFast Probe-based Assays in human, mouse, rat RASD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RASD2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasd21 , 5 RASD family, member 21, 5 88.6(n)1
    95.11(a)1
      8 (35.61 cM)5
    751411  NM_029182.11  NP_083458.11 
     752139445 
    chicken
    (Gallus gallus)
    Aves RASD21 RASD family, member 2 81.33(n)
    90.23(a)
      418057  XM_004937797.1  XP_004937854.1 
    lizard
    (Anolis carolinensis)
    Reptilia RASD26
    RASD family, member 2
    90(a)
    1 ↔ 1
    5(21678469-21684629)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.248802 Xenopus laevis transcribed sequence with weak similarity more 76.23(n)    BJ069624.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1141186
    zgc:114118
    33(a)
    many ↔ many
    3(47587827-47590319) ENSDARG00000052222
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86413 RAS small monomeric GTPase 48(a)
    (best of 2)
      65E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea D1081.46
    Protein D1081.4 (D1081.4) mRNA, complete cds
    27(a)
    many ↔ many
    I(8474849-8476282) WBGene00008382


    ENSEMBL Gene Tree for RASD2 (if available)
    TreeFam Gene Tree for RASD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RASD2 gene
    RAP2C2  RASL10B2  DIRAS12  RAP1B2  RIT22  RAP2A2  RIT12  RAP1A2  
    RAP2B2  RASD12  DIRAS22  RASL10A2  DIRAS32  
    Selected SIMAP similar genes for RASD2 using alignment to 1 protein entry:     RHES_HUMAN(see all similar genes):
    RASD1    DIRAS2    DKFZp547A0616    RAP2B    RAP2C    DIRAS1
    RAP2A    RAP1B    RAP1A    NRAS    RRAS    DIRAS3
    RALA    RERG    RAB5B    RIT1    RRAS2    MRAS

    Find genes that share paralogs with RASD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RASD2 (see all 344)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460812091,2
    --35935443(+) GGTTGC/GGGGTG 1 -- us2k10--------
    rs20921951,2
    C,F,A,H--35935475(+) GTCCAG/AGGATC 1 -- us2k1 tfbs315Minor allele frequency- A:0.30NS EA NA CSA WA 933
    rs96222231,2
    C,F--35935560(+) tcctgA/Gtatgt 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1856294591,2
    --35935747(+) TATGGC/TAAGTG 1 -- us2k10--------
    rs1904347371,2
    --35935842(+) TAAAAA/CATATA 1 -- us2k10--------
    rs1420691231,2
    --35935859(+) AATAAA/GTGGTG 1 -- us2k10--------
    rs734191901,2
    C,F--35935908(+) TAGGTG/CAAGCC 1 -- us2k15Minor allele frequency- C:0.33WA EA CSA 364
    rs783319721,2
    C,F--35935989(+) TCGGCC/TGTGGT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1508202511,2
    --35935990(+) CGGCCA/GTGGTC 1 -- us2k10--------
    rs1130342231,2
    C,F--35936027(+) TCTGGC/TTACTA 1 -- us2k11Minor allele frequency- T:0.01EA 218

    HapMap Linkage Disequilibrium report for RASD2 (35936915 - 35950048 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RASD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834184CNV Loss17160897
    esv1010711CNV Gain20482838
    nsv817990CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASD2
    DNA2.0 Custom Variant and Variant Library Synthesis for RASD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612842    OMIM disorders: --


    Find genes that share disorders with RASD2           About GenesLikeMe

    Genetic Association Database (GAD): RASD2
    Human Genome Epidemiology (HuGE) Navigator: RASD2 (1 document)

    Export disorders for RASD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RASD2 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with RASD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genes expressed in human tumor endothelium. (PubMed id 10947988)1, 2, 3 St Croix B....Kinzler K.W. (Science 2000)
    2. Identification of the monomeric G-protein, Rhes, as an efaroxan- regulated protein in the pancreatic beta-cell. (PubMed id 11976265)1, 2, 9 Chan S.L.F.... Morgan N.G. (Br. J. Pharmacol. 2002)
    3. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. (PubMed id 19255495)1, 2 Hill C.... Davey J. (Cell. Physiol. Biochem. 2009)
    4. RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive function. (PubMed id 18571626)1, 4 Liu Y.L....Hwu H.G. (Biol. Psychiatry 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors. (PubMed id 14724584)1, 3 Vargiu P....Bernal J. (Oncogene 2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    9. Rhes: A striatal-specific Ras homolog related to Dexras1. (PubMed id 10467249)1, 3 Falk J.D....Sutcliffe J.G. (J. Neurosci. Res. 1999)
    10. Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process. (PubMed id 16945334)1, 9 Taylor J.P....Chan S.L. (Biochem. Biophys. Res. Commun. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23551 HGNC: 18229 AceView: RASD2 Ensembl:ENSG00000100302 euGenes: HUgn23551
    ECgene: RASD2 H-InvDB: RASD2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RASD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RASD2 gene:
    Search GeneIP for patents involving RASD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of RASD2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RASD2   OriGene RNAi products in human, mouse, rat for RASD2  
     OriGene qPCR primer pairs and template standards for RASD2   OriGene Protein Over-expression Lysate for RASD2  
     OriGene MassSpec something-or-other for RASD2   OriGene clones in human, mouse for RASD2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RASD2   OriGene Purified Protein for RASD2  
     OriGene ORF clones in mouse, rat for RASD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RASD2   OriGene Custom Protein Services for RASD2  

     
     
     Block miRNA regulation of human, mouse, rat RASD2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RASD2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASD2 Predesigned siRNA for gene silencing in human, mouse, rat RASD2
     QuantiFast Probe-based Assays in human, mouse, rat RASD2 QuantiTect SYBR Green Assays in human, mouse, rat RASD2
     Custom PCR Arrays for RASD2 Search Chromatin IP Primers for RASD2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASD2  Search GeneGlobe Interaction Network for RASD2
     Regulatory tfbs in RASD2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RASD2 GenScript cDNA clones with any tag delivered in your preferred vector for RASD2
     GenScript Custom Assay Services for RASD2 GenScript Custom overexpressing Cell Line Services for RASD2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RASD2 (RHES)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RASD2 antibodies
     RASD2 proteins
     RASD2 lysates
     Antibodies for RASD2
     See all of Abcam's Antibodies, Kits and Proteins for RASD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RASD2
     Antibodies for RASD2
     ELISAs for RASD2
     CLIAs for RASD2



     Browse ESI BIO Cell Lines and PureStem Progenitors for RASD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASD2
     SwitchGear 3'UTR luciferase reporter plasmids for RASD2
     SwitchGear Promoter luciferase reporter plasmids for RASD2
     ThermoFisher Antibodies for RASD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASD2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASD2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RASD2
     LSBio Antibodies in human, mouse, rat for RASD2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RASD2
      Search eBioscience for proteins for RASD2
      Search eBioscience for elisas for RASD2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RASD2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4