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Aliases for RASD2 Gene

Aliases for RASD2 Gene

  • RASD Family, Member 2 2 3
  • Ras Homolog Enriched In Striatum 2 3 4
  • Tumor Endothelial Marker 2 2 3 4
  • TEM2 3 4 6
  • Rhes 3 6
  • GTP-Binding Protein Rhes 3
  • MGC:4834 3

External Ids for RASD2 Gene

Previous GeneCards Identifiers for RASD2 Gene

  • GC22P032586
  • GC22P034209
  • GC22P034261
  • GC22P035936
  • GC22P018896

Summaries for RASD2 Gene

Entrez Gene Summary for RASD2 Gene

  • This gene encodes a Ras-related protein that enriched in striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASD2 Gene

RASD2 (RASD Family, Member 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding and phosphatidylinositol 3-kinase binding. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for RASD2 Gene

  • GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.

Gene Wiki entry for RASD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASD2 Gene

Genomics for RASD2 Gene

Regulatory Elements for RASD2 Gene

Genomic Location for RASD2 Gene

Start:
35,540,507 bp from pter
End:
35,554,001 bp from pter
Size:
13,495 bases
Orientation:
Plus strand

Genomic View for RASD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASD2 Gene

Proteins for RASD2 Gene

  • Protein details for RASD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D21-RHES_HUMAN
    Recommended name:
    GTP-binding protein Rhes
    Protein Accession:
    Q96D21
    Secondary Accessions:
    • O95520
    • Q5THY8

    Protein attributes for RASD2 Gene

    Size:
    266 amino acids
    Molecular mass:
    30366 Da
    Quaternary structure:
    • Monomer (Potential). Interacts with PIK3CA and UBE2I (By similarity). Interacts with GNB1, GNB2 and GNB3. Interacts with HTT; interacts with mutant HTT (mHTT) with a much higher affinity than wild type HTT.
    Miscellaneous:
    • Reduces cell survival in striatal cells with Huntington disease by binding to mutant Huntington disease protein (mHTT; poly-Gln region with 82 repeats) and inducing sumoylation of mHTT
    SequenceCaution:
    • Sequence=AAG00868.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for RASD2 Gene

Proteomics data for RASD2 Gene at MOPED

Post-translational modifications for RASD2 Gene

  • Farnesylated. Farnesylation is required for membrane targeting (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASD2 Gene

Domains for RASD2 Gene

Suggested Antigen Peptide Sequences for RASD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96D21

UniProtKB/Swiss-Prot:

RHES_HUMAN :
  • Q96D21
Family:
  • Belongs to the small GTPase superfamily. RasD family.
genes like me logo Genes that share domains with RASD2: view

No data available for Gene Families for RASD2 Gene

Function for RASD2 Gene

Molecular function for RASD2 Gene

UniProtKB/Swiss-Prot Function: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.

Gene Ontology (GO) - Molecular Function for RASD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 11976265
GO:0005515 protein binding --
GO:0005525 GTP binding IEA --
GO:0031624 ubiquitin conjugating enzyme binding IEA --
GO:0031681 G-protein beta-subunit binding IPI 19255495
genes like me logo Genes that share ontologies with RASD2: view

Phenotypes for RASD2 Gene

genes like me logo Genes that share phenotypes with RASD2: view

Animal Models for RASD2 Gene

MGI Knock Outs for RASD2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RASD2 Gene

Localization for RASD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASD2 Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASD2 Gene COMPARTMENTS Subcellular localization image for RASD2 gene
Compartment Confidence
plasma membrane 5
cytosol 3
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for RASD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RASD2: view

Pathways for RASD2 Gene

SuperPathways for RASD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001963 synaptic transmission, dopaminergic IEA --
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RASD2: view

No data available for Pathways by source for RASD2 Gene

Compounds for RASD2 Gene

(1) HMDB Compounds for RASD2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RASD2: view

Transcripts for RASD2 Gene

mRNA/cDNA for RASD2 Gene

Unigene Clusters for RASD2 Gene

RASD family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASD2 Gene

No ASD Table

Relevant External Links for RASD2 Gene

GeneLoc Exon Structure for
RASD2
ECgene alternative splicing isoforms for
RASD2

Expression for RASD2 Gene

mRNA expression in normal human tissues for RASD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASD2 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (12.9), Brain - Caudate (basal ganglia) (9.3), and Brain - Nucleus accumbens (basal ganglia) (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASD2 Gene

SOURCE GeneReport for Unigene cluster for RASD2 Gene Hs.474711

mRNA Expression by UniProt/SwissProt for RASD2 Gene

Q96D21-RHES_HUMAN
Tissue specificity: Pancreatic endocrine cells (islets of Langerhans).
genes like me logo Genes that share expressions with RASD2: view

Orthologs for RASD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASD2 35
  • 99.62 (n)
  • 100 (a)
RASD2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASD2 35
  • 93.23 (n)
  • 98.5 (a)
RASD2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASD2 35
  • 93.36 (n)
  • 97.74 (a)
RASD2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasd2 35
  • 88.6 (n)
  • 95.11 (a)
Rasd2 16
Rasd2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASD2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASD2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasd2 35
  • 89.47 (n)
  • 95.11 (a)
chicken
(Gallus gallus)
Aves RASD2 35
  • 81.33 (n)
  • 90.23 (a)
RASD2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASD2 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24880 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rasd2 35
  • 75.44 (n)
  • 86.09 (a)
Str.12074 35
zebrafish
(Danio rerio)
Actinopterygii zgc:114118 36
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8641 36
  • 30 (a)
OneToMany
CG8641 37
  • 48 (a)
EG:BACR37P7.8 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea D1081.4 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for RASD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASD2 Gene

ENSEMBL:
Gene Tree for RASD2 (if available)
TreeFam:
Gene Tree for RASD2 (if available)

Paralogs for RASD2 Gene

Selected SIMAP similar genes for RASD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASD2: view

Variants for RASD2 Gene

Sequence variations from dbSNP and Humsavar for RASD2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs736210 -- 35,552,388(+) ACAAG(C/T)CTCAG utr-variant-3-prime
rs736211 -- 35,552,246(+) TTTCA(G/T)CTCCT utr-variant-3-prime
rs736212 -- 35,552,218(+) AGTCC(C/G)CTTGT utr-variant-3-prime
rs738367 -- 35,543,813(+) CCTCT(A/C)TCTGA intron-variant
rs742202 -- 35,550,703(+) CCAGG(A/C)ACGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASD2 Gene

Variant ID Type Subtype PubMed ID
nsv834184 CNV Loss 17160897
nsv817990 CNV Gain 17921354
esv1010711 CNV Gain 20482838

Relevant External Links for RASD2 Gene

HapMap Linkage Disequilibrium report
RASD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASD2 Gene

Disorders for RASD2 Gene

Relevant External Links for RASD2

Genetic Association Database (GAD)
RASD2
Human Genome Epidemiology (HuGE) Navigator
RASD2
genes like me logo Genes that share disorders with RASD2: view

No data available for UniProtKB/Swiss-Prot for RASD2 Gene

Publications for RASD2 Gene

  1. Identification of the monomeric G-protein, Rhes, as an efaroxan- regulated protein in the pancreatic beta-cell. (PMID: 11976265) Chan S.L.F. … Morgan N.G. (Br. J. Pharmacol. 2002) 3 4 23
  2. Genes expressed in human tumor endothelium. (PMID: 10947988) St Croix B. … Kinzler K.W. (Science 2000) 2 3 4
  3. RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive function. (PMID: 18571626) Liu Y.L. … Hwu H.G. (Biol. Psychiatry 2008) 3 48
  4. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. (PMID: 19255495) Hill C. … Davey J. (Cell. Physiol. Biochem. 2009) 3 4
  5. Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process. (PMID: 16945334) Taylor J.P. … Chan S.L. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for RASD2 Gene

Sources for RASD2 Gene

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