Aliases for RASD2 Gene
External Ids for RASD2 Gene
Previous GeneCards Identifiers for RASD2 Gene
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]
GeneCards Summary for RASD2 Gene
RASD2 (RASD Family Member 2) is a Protein Coding gene. Diseases associated with RASD2 include Huntington Disease. GO annotations related to this gene include GTP binding and ubiquitin conjugating enzyme binding. An important paralog of this gene is RAP2B.
UniProtKB/Swiss-Prot for RASD2 Gene
GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.