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Aliases for RASD1 Gene

Aliases for RASD1 Gene

  • RAS, Dexamethasone-Induced 1 2 3
  • DEXRAS1 3 4 6
  • Dexamethasone-Induced Ras-Related Protein 1 2 3
  • Activator Of G-Protein Signaling 1 3 4
  • Ras-Related Protein 2 3
  • AGS1 3 4
  • Activator Of G Protein Signaling 2
  • MGC:26290 3

External Ids for RASD1 Gene

Summaries for RASD1 Gene

Entrez Gene Summary for RASD1 Gene

  • This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

GeneCards Summary for RASD1 Gene

RASD1 (RAS, Dexamethasone-Induced 1) is a Protein Coding gene. Diseases associated with RASD1 include multiple myeloma and myeloma. Among its related pathways are MAPK targets/ Nuclear events mediated by MAP kinases and Neuroscience. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for RASD1 Gene

  • Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).

Gene Wiki entry for RASD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASD1 Gene

Genomics for RASD1 Gene

Genomic Location for RASD1 Gene

Start:
17,494,437 bp from pter
End:
17,496,395 bp from pter
Size:
1,959 bases
Orientation:
Minus strand

Genomic View for RASD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASD1 Gene

Regulatory Elements for RASD1 Gene

Proteins for RASD1 Gene

  • Protein details for RASD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y272-RASD1_HUMAN
    Recommended name:
    Dexamethasone-induced Ras-related protein 1
    Protein Accession:
    Q9Y272
    Secondary Accessions:
    • B2R709
    • B4DFF4
    • Q9NYB4

    Protein attributes for RASD1 Gene

    Size:
    281 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    • Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65 (By similarity).

    Alternative splice isoforms for RASD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASD1 Gene

Proteomics data for RASD1 Gene at MOPED

Post-translational modifications for RASD1 Gene

Other Protein References for RASD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASD1 Gene

Domains for RASD1 Gene

UniProtKB/Swiss-Prot:

RASD1_HUMAN
Family:
  • Belongs to the small GTPase superfamily. RasD family.:
    • Q9Y272
genes like me logo Genes that share domains with RASD1: view

No data available for Gene Families for RASD1 Gene

Function for RASD1 Gene

Molecular function for RASD1 Gene

UniProtKB/Swiss-Prot Function: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).
UniProtKB/Swiss-Prot Induction: By dexamethasone.

Gene Ontology (GO) - Molecular Function for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 10471929
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASD1: view
genes like me logo Genes that share phenotypes with RASD1: view

Animal Models for RASD1 Gene

MGI Knock Outs for RASD1:

miRNA for RASD1 Gene

miRTarBase miRNAs that target RASD1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RASD1 Gene

Localization for RASD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASD1 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASD1 Gene COMPARTMENTS Subcellular localization image for RASD1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
golgi apparatus 2
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with RASD1: view

Pathways for RASD1 Gene

genes like me logo Genes that share pathways with RASD1: view

Pathways by source for RASD1 Gene

1 Qiagen pathway for RASD1 Gene
2 Cell Signaling Technology pathways for RASD1 Gene
1 KEGG pathway for RASD1 Gene

Gene Ontology (GO) - Biological Process for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction TAS 10471929
GO:0007186 G-protein coupled receptor signaling pathway TAS 10840027
genes like me logo Genes that share ontologies with RASD1: view

Compounds for RASD1 Gene

(3) Novoseek inferred chemical compound relationships for RASD1 Gene

Compound -log(P) Hits PubMed IDs
dexamethasone 31.8 4
gtp 31.8 1
steroid 9.25 1
genes like me logo Genes that share compounds with RASD1: view

Transcripts for RASD1 Gene

mRNA/cDNA for RASD1 Gene

Unigene Clusters for RASD1 Gene

RAS, dexamethasone-induced 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASD1 Gene

No ASD Table

Relevant External Links for RASD1 Gene

GeneLoc Exon Structure for
RASD1
ECgene alternative splicing isoforms for
RASD1

Expression for RASD1 Gene

mRNA expression in normal human tissues for RASD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASD1 Gene

This gene is overexpressed in Liver (5.7) and Adipose - Visceral (Omentum) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASD1 Gene

SOURCE GeneReport for Unigene cluster for RASD1 Gene Hs.25829

mRNA Expression by UniProt/SwissProt for RASD1 Gene

Q9Y272-RASD1_HUMAN
Tissue specificity: Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues.
genes like me logo Genes that share expressions with RASD1: view

Orthologs for RASD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASD1 36
  • 99.88 (n)
  • 100 (a)
RASD1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASD1 36
  • 90.58 (n)
  • 86.96 (a)
RASD1 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASD1 36
  • 96.54 (n)
  • 97.49 (a)
RASD1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasd1 36
  • 88.33 (n)
  • 96.79 (a)
Rasd1 16
Rasd1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASD1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASD1 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasd1 36
  • 88.33 (n)
  • 96.43 (a)
chicken
(Gallus gallus)
Aves RASD1 36
  • 87.77 (n)
  • 88.13 (a)
RASD1 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASD1 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21562 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rasd1 36
  • 77.82 (n)
  • 84.59 (a)
Str.11968 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6072 36
zebrafish
(Danio rerio)
Actinopterygii rasd1 36
  • 75.22 (n)
  • 82.26 (a)
rasd1 37
  • 82 (a)
OneToOne
zgc65909 36
fruit fly
(Drosophila melanogaster)
Insecta CG8641 36
  • 56.82 (n)
  • 52.23 (a)
CG8641 37
  • 32 (a)
OneToMany
CG8641 38
  • 49 (a)
EG:BACR37P7.8 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea ssr-2 37
  • 25 (a)
ManyToMany
Species with no ortholog for RASD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASD1 Gene

ENSEMBL:
Gene Tree for RASD1 (if available)
TreeFam:
Gene Tree for RASD1 (if available)

Paralogs for RASD1 Gene

Selected SIMAP similar genes for RASD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASD1: view

Variants for RASD1 Gene

Sequence variations from dbSNP and Humsavar for RASD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs711352 -- 17,494,504(-) TGTGT(C/G)TGAGG utr-variant-3-prime
rs1077790 -- 17,494,575(+) TAAAG(G/T)GCAAG utr-variant-3-prime
rs1671823 -- 17,494,591(+) TTTTG(G/T)GTTCC utr-variant-3-prime
rs1726489 -- 17,494,601(+) CTTTG(G/T)GCAGT utr-variant-3-prime
rs2232827 -- 17,497,036(-) AGCTC(C/T)GCCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RASD1 Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER Inversion 15895083
nsv499114 OTHER Inversion 21111241
nsv907729 CNV Loss 21882294
nsv907730 CNV Loss 21882294
nsv907731 CNV Loss 21882294
dgv3067n71 CNV Loss 21882294
dgv3068n71 CNV Loss 21882294
nsv907737 CNV Loss 21882294

Relevant External Links for RASD1 Gene

HapMap Linkage Disequilibrium report
RASD1

Disorders for RASD1 Gene

(2) MalaCards Diseases for RASD1 Gene

Search for RASD1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for RASD1 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for RASD1

Human Genome Epidemiology (HuGE) Navigator
RASD1
genes like me logo Genes that share disorders with RASD1: view

No data available for UniProtKB/Swiss-Prot for RASD1 Gene

Publications for RASD1 Gene

  1. Identification of a glucocorticoid response element in the 3'- flanking region of the human Dexras1 gene. (PMID: 12818426) Kemppainen R.J. … Ammons J.M. (Biochim. Biophys. Acta 2003) 3 4 23
  2. Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes. (PMID: 11842095) Takesono A. … Lanier S.M. (J. Biol. Chem. 2002) 3 23
  3. Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells. (PMID: 9452419) Kemppainen R.J. … Behrend E.N. (J. Biol. Chem. 1998) 3 23
  4. Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling. (PMID: 16489124) Nguyen C.H. … Watts V.J. (Mol. Pharmacol. 2006) 3 23
  5. Genes expressed in human tumor endothelium. (PMID: 10947988) St Croix B. … Kinzler K.W. (Science 2000) 2 3

Products for RASD1 Gene

Sources for RASD1 Gene

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