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Aliases for RASD1 Gene

Aliases for RASD1 Gene

  • Ras Related Dexamethasone Induced 1 2 3 5
  • Dexamethasone-Induced Ras-Related Protein 1 2 3
  • Activator Of G-Protein Signaling 1 3 4
  • RAS, Dexamethasone-Induced 1 2 3
  • Ras-Related Protein 2 3
  • DEXRAS1 3 4
  • AGS1 3 4
  • Activator Of G Protein Signaling 2
  • MGC:26290 3

External Ids for RASD1 Gene

Previous GeneCards Identifiers for RASD1 Gene

  • GC17M017712
  • GC17M018770
  • GC17M017340
  • GC17M017598
  • GC17M017341
  • GC17M017150

Summaries for RASD1 Gene

Entrez Gene Summary for RASD1 Gene

  • This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

GeneCards Summary for RASD1 Gene

RASD1 (Ras Related Dexamethasone Induced 1) is a Protein Coding gene. Diseases associated with RASD1 include Prostate Leiomyosarcoma. Among its related pathways are Circadian entrainment and MAP Kinase Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASD2.

UniProtKB/Swiss-Prot for RASD1 Gene

  • Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).

Gene Wiki entry for RASD1 Gene

Additional gene information for RASD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASD1 Gene

Genomics for RASD1 Gene

GeneHancer (GH) Regulatory Elements for RASD1 Gene

Promoters and enhancers for RASD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I017493 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.1 1088 4.5 ATF1 SIN3A DMAP1 ZNF48 GLIS2 ZNF143 RUNX3 ZNF202 SP3 RXRA RASD1 LOC100419436 DRG2 LOC644422 ENSG00000265511 RAI1 TOP3A SMCR8 ACTG1P24 MPRIP
GH17I017522 Enhancer 0.9 ENCODE dbSUPER 13 -26.9 -26895 1.5 CTCF FEZF1 ZIC2 ZFHX2 GLIS2 PRDM10 ZBTB20 EGR2 MAZ ZNF398 PEMT RASD1 MED9 KRT16P6 GC17M017508 ENSG00000265511
GH17I017461 Enhancer 0.8 ENCODE 11.3 +34.1 34089 1.2 ELF3 FOXA2 ARID4B RAD21 THRB RARA CREM THAP11 MIXL1 SP5 GC17P017462 ENSG00000201741 RASD1 PEMT MED9
GH17I017527 Enhancer 0.7 dbSUPER 12.5 -32.2 -32199 2.7 FOXA2 RXRA MAX MNT REST ZIC2 RAD21 FOXA1 NR2F2 YY1 PIR49850 PEMT RASD1 MED9 ATPAF2 KRT16P6 GC17M017544
GH17I017467 Enhancer 0.7 ENCODE dbSUPER 12.2 +28.4 28431 1.2 MAZ POLR2A GLIS1 ZNF140 ZBTB17 DRG2 LOC644422 RAI1 RASD1 DRC3 PEMT LOC100419436 ENSG00000265511 ACTG1P24 ENSG00000201741
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RASD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASD1 gene promoter:

Genomic Locations for RASD1 Gene

Genomic Locations for RASD1 Gene
chr17:17,494,437-17,496,395
(GRCh38/hg38)
Size:
1,959 bases
Orientation:
Minus strand
chr17:17,397,751-17,399,709
(GRCh37/hg19)

Genomic View for RASD1 Gene

Genes around RASD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASD1 Gene

Proteins for RASD1 Gene

  • Protein details for RASD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y272-RASD1_HUMAN
    Recommended name:
    Dexamethasone-induced Ras-related protein 1
    Protein Accession:
    Q9Y272
    Secondary Accessions:
    • B2R709
    • B4DFF4
    • Q9NYB4

    Protein attributes for RASD1 Gene

    Size:
    281 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    • Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65 (By similarity).

    Alternative splice isoforms for RASD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASD1 Gene

Post-translational modifications for RASD1 Gene

Other Protein References for RASD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASD1 Gene

Domains & Families for RASD1 Gene

Gene Families for RASD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RASD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y272

UniProtKB/Swiss-Prot:

RASD1_HUMAN :
  • Belongs to the small GTPase superfamily. RasD family.
Family:
  • Belongs to the small GTPase superfamily. RasD family.
genes like me logo Genes that share domains with RASD1: view

Function for RASD1 Gene

Molecular function for RASD1 Gene

UniProtKB/Swiss-Prot Function:
Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).
UniProtKB/Swiss-Prot Induction:
By dexamethasone.

Phenotypes From GWAS Catalog for RASD1 Gene

Gene Ontology (GO) - Molecular Function for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASD1: view
genes like me logo Genes that share phenotypes with RASD1: view

Animal Models for RASD1 Gene

MGI Knock Outs for RASD1:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASD1 Gene

Localization for RASD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASD1 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASD1 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 3
endoplasmic reticulum 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with RASD1: view

Pathways & Interactions for RASD1 Gene

genes like me logo Genes that share pathways with RASD1: view

Pathways by source for RASD1 Gene

2 Cell Signaling Technology pathways for RASD1 Gene
1 KEGG pathway for RASD1 Gene
1 Qiagen pathway for RASD1 Gene

Gene Ontology (GO) - Biological Process for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10471929
GO:0007186 G-protein coupled receptor signaling pathway TAS 10840027
GO:0007263 nitric oxide mediated signal transduction IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with RASD1: view

No data available for SIGNOR curated interactions for RASD1 Gene

Drugs & Compounds for RASD1 Gene

(1) Drugs for RASD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RASD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RASD1: view

Transcripts for RASD1 Gene

mRNA/cDNA for RASD1 Gene

Unigene Clusters for RASD1 Gene

RAS, dexamethasone-induced 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASD1 Gene

No ASD Table

Relevant External Links for RASD1 Gene

GeneLoc Exon Structure for
RASD1
ECgene alternative splicing isoforms for
RASD1

Expression for RASD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASD1 Gene

This gene is overexpressed in Liver (x5.7) and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for RASD1 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASD1 Gene



Protein tissue co-expression partners for RASD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASD1 Gene:

RASD1

SOURCE GeneReport for Unigene cluster for RASD1 Gene:

Hs.25829

mRNA Expression by UniProt/SwissProt for RASD1 Gene:

Q9Y272-RASD1_HUMAN
Tissue specificity: Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues.

Evidence on tissue expression from TISSUES for RASD1 Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Kidney(2.6)
  • Muscle(2.5)
  • Pancreas(2.3)
  • Heart(2.2)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with RASD1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASD1 Gene

Orthologs for RASD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASD1 33 34
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia RASD1 33 34
  • 96.54 (n)
oppossum
(Monodelphis domestica)
Mammalia RASD1 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASD1 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASD1 33 34
  • 90.58 (n)
mouse
(Mus musculus)
Mammalia Rasd1 33 16 34
  • 88.33 (n)
rat
(Rattus norvegicus)
Mammalia Rasd1 33
  • 88.33 (n)
chicken
(Gallus gallus)
Aves RASD1 33 34
  • 87.77 (n)
lizard
(Anolis carolinensis)
Reptilia RASD1 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasd1 33
  • 77.82 (n)
Str.11968 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.21562 33
zebrafish
(Danio rerio)
Actinopterygii rasd1 33 34
  • 75.22 (n)
zgc65909 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6072 33
fruit fly
(Drosophila melanogaster)
Insecta CG8641 35 33 34
  • 56.82 (n)
EG:BACR37P7.8 35
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea ssr-2 34
  • 25 (a)
ManyToMany
Species where no ortholog for RASD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASD1 Gene

ENSEMBL:
Gene Tree for RASD1 (if available)
TreeFam:
Gene Tree for RASD1 (if available)

Paralogs for RASD1 Gene

(17) SIMAP similar genes for RASD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASD1: view

Variants for RASD1 Gene

Sequence variations from dbSNP and Humsavar for RASD1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000664295 -- 17,494,735(-) G/A 3_prime_UTR_variant
rs1000943014 -- 17,496,339(-) G/A 5_prime_UTR_variant
rs1001202481 -- 17,494,991(-) C/G 3_prime_UTR_variant
rs1001312983 -- 17,494,148(-) C/T downstream_transcript_variant
rs1001543683 -- 17,497,166(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RASD1 Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER inversion 15895083
nsv499114 OTHER inversion 21111241

Variation tolerance for RASD1 Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASD1 Gene

Disorders for RASD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prostate leiomyosarcoma
  • leiomyosarcoma of the prostate
- elite association - COSMIC cancer census association via MalaCards
Search RASD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RASD1

genes like me logo Genes that share disorders with RASD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASD1 Gene

Publications for RASD1 Gene

  1. Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene. (PMID: 12818426) Kemppainen RJ … Ammons JM (Biochimica et biophysica acta 2003) 3 4 22 58
  2. Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling. (PMID: 16489124) Nguyen CH … Watts VJ (Molecular pharmacology 2006) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes. (PMID: 11842095) Takesono A … Lanier SM (The Journal of biological chemistry 2002) 3 22 58
  5. Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue. (PMID: 12498886) Jaffrey SR … Snyder SH (Chemistry & biology 2002) 3 4 58

Products for RASD1 Gene

Sources for RASD1 Gene

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