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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASD1 Gene

protein-coding   GIFtS: 56
GCID: GC17M017397

RAS, dexamethasone-induced 1
 Explore 10 diseases affiliated with
RASD1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RASD1    

Aliases
for RASD1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAS, Dexamethasone-Induced 11 2     MGC:262902
DEXRAS11 2 3 5     Dexamethasone-Induced Ras-Related Protein 12
AGS11 2 3     Ras-Related Protein2
Activator Of G-Protein Signaling 12 3     

External Ids:    HGNC: 158281   Entrez Gene: 516552   Ensembl: ENSG000001085517   OMIM: 6055505   UniProtKB: Q9Y2723   

Export aliases for RASD1 gene to outside databases

Previous GC identifers: GC17M017712 GC17M018770 GC17M017340 GC17M017598 GC17M017341 GC17M017150


Summaries
for RASD1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RASD1:
This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein
is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This
protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which
interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced
alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this
gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: RASD1_HUMAN, Q9Y272
Function: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via
its interaction with APBB1/FE65 (By similarity)

Gene Wiki entry for RASD1


Genomic Views
for RASD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASD1 gene promoter:
         CREB   p53   deltaCREB   Arnt   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RASD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RASD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

RASD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASD1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M017397:  view genomic region     (about GC identifiers)

Start:
 17,397,751 bp from pter      End:
 17,399,709 bp from pter
Size:
 1,959 bases      Orientation:
 minus strand

Proteins
for RASD1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RASD1_HUMAN, Q9Y272 (See protein sequence)
Recommended Name: Dexamethasone-induced Ras-related protein 1 precursor  
Size: 281 amino acids; 31642 Da
Subunit: Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1, RASD1/DEXRAS1
and APP. Interacts with APBB1/FE65 (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, perinuclear region (By
similarity). Nucleus (By similarity)
Secondary accessions: B2R709 Q9NYB4

Explore the universe of human proteins at neXtProt for RASD1: NX_Q9Y272

Post-translational modifications:

  • S-nitrosylation stimulates guanine-nucleotide exchange activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y272

    • RASD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186918.1  NP_057168.1  

    ENSEMBL proteins: 
     ENSP00000225688   ENSP00000463388  

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    Novus Biologicals RASD1 Proteins
    Novus Biologicals RASD1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RASD1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--


    RASD1 for ontologies           About GeneDecksing



    RASD1 Antibody Products: 
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    Uscn Antibodies for RASD1
    Search ThermoFisher Antibodies for RASD1

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    Uscn ELISAs and CLIAs for RASD1

    Protein Domains /
    Families
    for RASD1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RASD1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q9Y272

    ProtoNet protein and cluster: Q9Y272

    2 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RASD1_HUMAN, Q9Y272
    Similarity: Belongs to the small GTPase superfamily. RasD family


    Function
    for RASD1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RASD1_HUMAN, Q9Y272
    Function: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via
    its interaction with APBB1/FE65 (By similarity)
    Induction: By dexamethasone

    miRNA
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    hsa-mir-375 (MIRT004439)

    OriGene 3'-UTR Clone: RASD1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASD1
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RASD1 (see all 26):
    hsa-miR-30c hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-375
    SwitchGear 3'UTR luciferase reporter plasmid: RASD1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RASD1 (see all 4)
    OriGene shRNA RFP: RASD1
    OriGene siRNA: RASD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASD1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RASD1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASD1 (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RASD1 (NM_016084)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASD1 

    Cell Line
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    Search LifeMap BioReagents cell lines for RASD1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASD1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--


    RASD1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Rasd1tm1Pngr for RASD1
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Rasd1):
     behavior/neurological 

    RASD1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RASD1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    		Neuroscience1.00
    2MAP Kinase Signaling
    		MAP Kinase Signaling1.00
    3Selected targets of GCR-alpha
    		Selected targets of GCR-alpha1.00
    4Selected targets of ESR1
    		Selected targets of ESR11.00
    5nNOS Signaling at Neuronal Synapses
    		nNOS Signaling at Neuronal Synapses1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for RASD1
        Selected targets of ESR1
    Selected targets of GCR-alpha

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RASD1
        nNOS Signaling at Neuronal Synapses

    2 Cell Signaling Technology (CST) Pathways for RASD1
        MAP Kinase Signaling
    Neuroscience



    RASD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RASD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/17 Interacting proteins for RASD1 (Q9Y2722, 3 ENSP000002256884) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLSCR1O151622, 3, ENSP000003454944MINT-66109 I2D: score=5 STRING: ENSP00000345494
    NOS1P294753, ENSP000003207584I2D: score=2 STRING: ENSP00000320758
    GNB1P628733, ENSP000003678724I2D: score=1 STRING: ENSP00000367872
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction TAS10673050
    GO:0007186G-protein coupled receptor signaling pathway TAS10840027
    GO:0007263nitric oxide mediated signal transduction IEA--
    GO:0007264small GTPase mediated signal transduction IEA--


    RASD1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RASD1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RASD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RASD1
    3 Novoseek chemical compound relationships for RASD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dexamethasone 31.8 5 9452419 (2), 11356714 (1), 10467249 (1)
    gtp 31.8 1 11356714 (1)
    steroid 9.25 1 15020218 (1)

    Search CenterWatch for drugs/clinical trials and news about RASD1 

    Transcripts
    for RASD1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RASD1 gene (2 alternative transcripts): 
    NM_001199989.1  NM_016084.4  

    Unigene Cluster for RASD1:

    RAS, dexamethasone-induced 1
    Hs.25829  [show with all ESTs]
    Unigene Representative Sequence: NM_016084
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225688(uc002gri.3 uc021trg.1) ENST00000579152

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASD1
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RASD1 (see all 26):
    hsa-miR-30c hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-375
    SwitchGear 3'UTR luciferase reporter plasmid: RASD1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RASD1 (see all 4)
    OriGene shRNA RFP: RASD1
    OriGene siRNA: RASD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASD1
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RASD1 (NM_016084)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASD1 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RASD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASD1

    Additional cDNA sequence: 

    AF069506.1 AF153192.1 AF172846.1 AF177335.1 AF498923.1 AK294073.1 AK312796.1 BC018041.1 
    BC042688.1 

    2 DOTS entries:

    DT.210789  DT.120953287 

    24/178 AceView cDNA sequences (see all 178):

    BF057610 BI823596 BM311047 BM543630 BI759201 CD513372 AF498923 CD513046 
    CD251380 CA390264 CD676181 BM921737 CB217058 CR596563 AW237682 AI197818 
    BF195653 AI680345 AA663015 CB178037 AI589181 BU736435 BP349414 AI973193 

    GeneLoc Exon Structure


    Expression
    for RASD1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACACGAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RASD1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    OvaryAntral FollicleCumulus CellsOvary
    AdiposeBody Subcutaneous White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)Adipose

    See RASD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASD1

    SOURCE GeneReport for Unigene cluster: Hs.25829

    UniProtKB/Swiss-Prot: RASD1_HUMAN, Q9Y272
    Tissue specificity: Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung,
    liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including RASD1: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Neurotoxicity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASD1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASD1

    Orthologs
    for RASD1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RASD1 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RASD11 RAS, dexamethasone-induced 1 87.77(n)
    88.13(a)    		   416507  NM_001044636.1  NP_001038101.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RASD16
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343500.1(284588-287208)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.215622 Xenopus laevis ras-related protein mRNA, partial cds 79.02(n)    AF170335.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc659092 hypothetical protein MGC65909 78.73(n)   393504  BC056272.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG86411 , 3 RAS small monomeric GTPase3
    CG86411    		 49(a)
    (best of 2)3
    58.13(n)1
    54.13(a)1    		   65E33
    387711  NM_139816.21  NP_648073.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea D1081.46
    		 --
    		 26(a)
    		 possible ortholog
    		 I(8474843-8476276)


    ENSEMBL Gene Tree for RASD1 (if available)
    TreeFam Gene Tree for RASD1 (if available) 

    Paralogs
    for RASD1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASD1 gene
    RAP2C2  RASL10B2  DIRAS12  RAP1B2  RASD22  RAP2A2  RAP1A2  RAP2B2  
    DIRAS22  RASL10A2  DIRAS32  
    18/19 SIMAP similar genes for RASD1 using alignment to 2 protein entries:     RASD1_HUMAN (see all proteins) (see all similar genes):
    RASD2    c-bas/has    RAP1B    DIRAS1    RAP2A    DKFZp547A0616
    RALB    RANP1    RAP2B    RHEBL1    RALA    RAP2C
    RAP1A    NRAS    DIRAS2    RRAS2    MRAS    RIT1

    RASD1 for paralogs           About GeneDecksing



    Genomic Variants
    for RASD1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/83 NCBI SNPs in RASD1 are shown (see all 83)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1443146371,2
    		--17397362(+) CCCACA/GCTGAG 2 -- int10--------
    rs1156127701,2
    		F,--17397409(+) TTTTAC/AGCTGA 2 -- int13Minor allele frequency- A:0.08WA NA EA 358
    rs1843849181,2
    		--17397410(+) TTTACA/GCTGAA 2 -- int10--------
    rs49248681,2
    		C,A,H,--17397512(+) AGGGGG/AGACCC 2 -- int110Minor allele frequency- A:0.41NA CSA WA EA 372
    rs1884322141,2
    		--17397598(+) CTGGCA/GGCTGA 2 -- int10--------
    rs129383871,2
    		C--17397720(+) CATCTC/TTAAAA 2 -- int12Minor allele frequency- T:0.25NA 4
    rs739789381,2
    		C--17397727(+) AAAAGA/CAAAAA 2 -- int11Minor allele frequency- C:0.00WA 2
    rs7113521,2
    		C,F,A,H,--17397818(-) TGTGTG/CTGAGG 2 -- ut31 ese315Minor allele frequency- C:0.44NS EA MN NA WA CSA 957
    rs1130656591,2
    		--17397873(+) ACACCG/AGAACT 2 -- ut311Minor allele frequency- A:0.50CSA 2
    rs16718231,2
    		F--17397905(+) TTTTGT/GGTTCC 2 -- ut31 ese31Minor allele frequency- G:0.05MN 184

    HapMap Linkage Disequilibrium report for RASD1 (17397751 - 17399709 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RASD1
         1 Inversion: 0495

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    Disorders / Diseases
    for RASD1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RASD1 for disorders           About GeneDecksing

    OMIM gene information: 605550    OMIM disorders: --

    10 diseases for RASD1:    About MalaCards
    multiple myeloma    myeloma    smith-magenis syndrome    alzheimer's disease
    leiomyosarcoma    neuronitis    prostate leiomyosarcoma    gigantism
    prostatitis    pancreatitis

    1 Novoseek disease relationship for RASD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 10234739 (1)

    Human Genome Epidemiology (HuGE) Navigator: RASD1 (1 document)

    Export disorders for RASD1 gene to outside databases

    Publications
    for RASD1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASD1 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with RASD1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a glucocorticoid response element in the 3'- flanking region of the human Dexras1 gene. (PubMed id 12818426)1, 2, 9 Kemppainen R.J.... Ammons J.M. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue. (PubMed id 12498886)1, 2 Jaffrey S.R.... Snyder S.H. (2002)
    4. Genes expressed in human tumor endothelium. (PubMed id 10947988)1, 3 St Croix B....Kinzler K.W. (2000)
    5. Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone. (PubMed id 10673050)1, 2 Tu Y. and Wu C. (1999)
    6. Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling. (PubMed id 10471929)1, 2 Cismowski M.J.... Duzic E. (1999)
    7. Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling. (PubMed id 16489124)1, 9 Nguyen C.H. and Watts V.J. (2006)
    8. Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes. (PubMed id 11842095)1, 9 Takesono A....Lanier S.M. (2002)
    9. Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells. (PubMed id 9452419)1, 9 Kemppainen R.J. and Behrend E.N. (1998)
    10. Rasd1 interacts with Ear2 (Nr2f6) to regulate renin t ranscription. (PubMed id 21247419)1 Tan J.J....Chen K.S. (2011)

    External Searches for RASD1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RASD1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51655 HGNC: 15828 AceView: RASD1 Ensembl:ENSG00000108551 euGenes: HUgn51655
    ECgene: RASD1 H-InvDB: RASD1

    Other Databases showing RASD1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RASD1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASD1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RASD1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RASD1 gene:
    Search GeneIP for patents involving RASD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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