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Aliases for RASD1 Gene

Aliases for RASD1 Gene

  • Ras Related Dexamethasone Induced 1 2 3 5
  • Dexamethasone-Induced Ras-Related Protein 1 2 3
  • Activator Of G-Protein Signaling 1 3 4
  • RAS, Dexamethasone-Induced 1 2 3
  • Ras-Related Protein 2 3
  • DEXRAS1 3 4
  • AGS1 3 4
  • Activator Of G Protein Signaling 2
  • MGC:26290 3

External Ids for RASD1 Gene

Previous GeneCards Identifiers for RASD1 Gene

  • GC17M017712
  • GC17M018770
  • GC17M017340
  • GC17M017598
  • GC17M017341
  • GC17M017150

Summaries for RASD1 Gene

Entrez Gene Summary for RASD1 Gene

  • This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

GeneCards Summary for RASD1 Gene

RASD1 (Ras Related Dexamethasone Induced 1) is a Protein Coding gene. Diseases associated with RASD1 include Prostate Leiomyosarcoma and Multiple Myeloma. Among its related pathways are Neuroscience and MAP Kinase Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASD2.

UniProtKB/Swiss-Prot for RASD1 Gene

  • Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).

Gene Wiki entry for RASD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASD1 Gene

Genomics for RASD1 Gene

Regulatory Elements for RASD1 Gene

Enhancers for RASD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G017522 1 ENCODE dbSUPER 13 -26.9 -26895 1.5 CTCF FEZF1 RAD21 ZIC2 ZFHX2 ZNF316 GLIS2 PRDM10 ZBTB20 EGR2 PEMT RASD1 MED9 KRT16P6 GC17M017508 ENSG00000265511
GH17G017461 0.9 ENCODE 11.3 +34.1 34090 1.2 ELF3 FOXA2 CREB3L1 ARID4B RAD21 THRB RARA GATA4 CREM MIXL1 RASD1 PEMT ENSG00000201741 MED9
GH17G017467 0.8 ENCODE dbSUPER 12.2 +28.4 28431 1.2 MAZ POLR2A SMARCA4 GLIS1 ZNF140 ZNF384 RASD1 PEMT ENSG00000201741 MED9
GH17G017525 0.7 ENCODE dbSUPER 13 -29.9 -29851 1.4 GATAD2A CEBPA YY1 PEMT RASD1 MED9 ATPAF2 KRT16P6 PIR49850 GC17M017508
GH17G017527 0.7 dbSUPER 12.5 -32.2 -32200 2.7 SAP130 MAX ZIC2 RAD21 YY1 ZSCAN5C HNF4G GATAD2A CEBPB MNT PEMT RASD1 MED9 ATPAF2 KRT16P6 PIR49850 GC17M017544
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASD1 on UCSC Golden Path with GeneCards custom track

Promoters for RASD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000282630 95 1401 ATF1 AGO1 DMAP1 ZNF48 GLIS2 ZNF143 ZNF202 ZNF263 SP3 SP5
ENSR00000091925 1395 401 CTCF MXI1 RNF2 AGO1 CHD1 CBX2 EP300 JUND GATA3 EZH2

Genomic Location for RASD1 Gene

Chromosome:
17
Start:
17,494,437 bp from pter
End:
17,496,395 bp from pter
Size:
1,959 bases
Orientation:
Minus strand

Genomic View for RASD1 Gene

Genes around RASD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASD1 Gene

Proteins for RASD1 Gene

  • Protein details for RASD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y272-RASD1_HUMAN
    Recommended name:
    Dexamethasone-induced Ras-related protein 1
    Protein Accession:
    Q9Y272
    Secondary Accessions:
    • B2R709
    • B4DFF4
    • Q9NYB4

    Protein attributes for RASD1 Gene

    Size:
    281 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    • Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65 (By similarity).

    Alternative splice isoforms for RASD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASD1 Gene

Post-translational modifications for RASD1 Gene

  • S-nitrosylation stimulates guanine-nucleotide exchange activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASD1 Gene

Domains & Families for RASD1 Gene

Suggested Antigen Peptide Sequences for RASD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y272

UniProtKB/Swiss-Prot:

RASD1_HUMAN :
  • Belongs to the small GTPase superfamily. RasD family.
Family:
  • Belongs to the small GTPase superfamily. RasD family.
genes like me logo Genes that share domains with RASD1: view

No data available for Gene Families for RASD1 Gene

Function for RASD1 Gene

Molecular function for RASD1 Gene

UniProtKB/Swiss-Prot Function:
Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).
UniProtKB/Swiss-Prot Induction:
By dexamethasone.

Gene Ontology (GO) - Molecular Function for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASD1: view
genes like me logo Genes that share phenotypes with RASD1: view

Animal Models for RASD1 Gene

MGI Knock Outs for RASD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for RASD1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASD1 Gene

Localization for RASD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASD1 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASD1 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 3
endoplasmic reticulum 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with RASD1: view

Pathways & Interactions for RASD1 Gene

genes like me logo Genes that share pathways with RASD1: view

Pathways by source for RASD1 Gene

2 Cell Signaling Technology pathways for RASD1 Gene
1 KEGG pathway for RASD1 Gene
1 Qiagen pathway for RASD1 Gene

Gene Ontology (GO) - Biological Process for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10471929
GO:0007186 G-protein coupled receptor signaling pathway TAS 10840027
GO:0007263 nitric oxide mediated signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with RASD1: view

No data available for SIGNOR curated interactions for RASD1 Gene

Drugs & Compounds for RASD1 Gene

(1) Drugs for RASD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RASD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RASD1: view

Transcripts for RASD1 Gene

mRNA/cDNA for RASD1 Gene

Unigene Clusters for RASD1 Gene

RAS, dexamethasone-induced 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASD1 Gene

No ASD Table

Relevant External Links for RASD1 Gene

GeneLoc Exon Structure for
RASD1
ECgene alternative splicing isoforms for
RASD1

Expression for RASD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASD1 Gene

This gene is overexpressed in Liver (x5.7) and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for RASD1 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASD1 Gene



Protein tissue co-expression partners for RASD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASD1 Gene:

RASD1

SOURCE GeneReport for Unigene cluster for RASD1 Gene:

Hs.25829

mRNA Expression by UniProt/SwissProt for RASD1 Gene:

Q9Y272-RASD1_HUMAN
Tissue specificity: Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues.

Evidence on tissue expression from TISSUES for RASD1 Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Kidney(2.7)
  • Muscle(2.5)
  • Heart(2.3)
  • Pancreas(2.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with RASD1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASD1 Gene

Orthologs for RASD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASD1 34 35
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia RASD1 34 35
  • 96.54 (n)
oppossum
(Monodelphis domestica)
Mammalia RASD1 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASD1 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASD1 34 35
  • 90.58 (n)
mouse
(Mus musculus)
Mammalia Rasd1 34 16 35
  • 88.33 (n)
rat
(Rattus norvegicus)
Mammalia Rasd1 34
  • 88.33 (n)
chicken
(Gallus gallus)
Aves RASD1 34 35
  • 87.77 (n)
lizard
(Anolis carolinensis)
Reptilia RASD1 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasd1 34
  • 77.82 (n)
Str.11968 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21562 34
zebrafish
(Danio rerio)
Actinopterygii rasd1 34 35
  • 75.22 (n)
zgc65909 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6072 34
fruit fly
(Drosophila melanogaster)
Insecta CG8641 36 34 35
  • 56.82 (n)
EG:BACR37P7.8 36
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea ssr-2 35
  • 25 (a)
ManyToMany
Species where no ortholog for RASD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASD1 Gene

ENSEMBL:
Gene Tree for RASD1 (if available)
TreeFam:
Gene Tree for RASD1 (if available)

Paralogs for RASD1 Gene

(17) SIMAP similar genes for RASD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASD1: view

Variants for RASD1 Gene

Sequence variations from dbSNP and Humsavar for RASD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000664295 -- 17,494,735(+) CGTGG(A/G)TCCTG utr-variant-3-prime
rs1000943014 -- 17,496,339(+) GCTCG(A/G)GCTAG utr-variant-5-prime
rs1001202481 -- 17,494,991(+) CCTCC(C/G)CAGTG utr-variant-3-prime
rs1001312983 -- 17,494,148(+) CTAAC(C/T)CAAAG downstream-variant-500B
rs1001543683 -- 17,497,166(+) CCTGC(C/T)CCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RASD1 Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER inversion 15895083
nsv499114 OTHER inversion 21111241

Variation tolerance for RASD1 Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASD1 Gene

Disorders for RASD1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RASD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate leiomyosarcoma
  • leiomyosarcoma of the prostate
multiple myeloma
  • myeloma, multiple amyloidosis, systemic, included
- elite association - COSMIC cancer census association via MalaCards
Search RASD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RASD1

Human Genome Epidemiology (HuGE) Navigator
RASD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASD1
genes like me logo Genes that share disorders with RASD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASD1 Gene

Publications for RASD1 Gene

  1. Identification of a glucocorticoid response element in the 3'- flanking region of the human Dexras1 gene. (PMID: 12818426) Kemppainen R.J. … Ammons J.M. (Biochim. Biophys. Acta 2003) 3 4 22 64
  2. Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling. (PMID: 16489124) Nguyen C.H. … Watts V.J. (Mol. Pharmacol. 2006) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes. (PMID: 11842095) Takesono A. … Lanier S.M. (J. Biol. Chem. 2002) 3 22 64
  5. Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue. (PMID: 12498886) Jaffrey S.R. … Snyder S.H. (Chem. Biol. 2002) 3 4 64

Products for RASD1 Gene

Sources for RASD1 Gene

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