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RASD1 Gene

protein-coding   GIFtS: 56
GCID: GC17M017397

RAS, Dexamethasone-Induced 1

  See RASD1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAS, Dexamethasone-Induced 11 2     Activator Of G-Protein Signaling 12 3
DEXRAS12 3 5     AGS12 3
Dexamethasone-Induced Ras-Related Protein 11 2     Activator Of G Protein Signaling1
Ras-Related Protein1 2     MGC:262902

External Ids:    HGNC: 158281   Entrez Gene: 516552   Ensembl: ENSG000001085517   OMIM: 6055505   UniProtKB: Q9Y2723   

Export aliases for RASD1 gene to outside databases

Previous GC identifers: GC17M017712 GC17M018770 GC17M017340 GC17M017598 GC17M017341 GC17M017150


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RASD1 Gene:
This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded
protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go
proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor
protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role
in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions.
Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma
cells. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene.(provided by RefSeq, Sep 2011)

GeneCards Summary for RASD1 Gene:
RASD1 (RAS, dexamethasone-induced 1) is a protein-coding gene. Diseases associated with RASD1 include myeloma, and multiple myeloma. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RASD1_HUMAN, Q9Y272
Function: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex
via its interaction with APBB1/FE65 (By similarity)

Gene Wiki entry for RASD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASD1 gene promoter:
         CREB   p53   deltaCREB   Arnt   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASD1 promoter sequence
   Search Chromatin IP Primers for RASD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

RASD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASD1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M017397:  view genomic region     (about GC identifiers)

Start:
17,397,751 bp from pter      End:
17,399,709 bp from pter
Size:
1,959 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RASD1_HUMAN, Q9Y272 (See protein sequence)
Recommended Name: Dexamethasone-induced Ras-related protein 1 precursor  
Size: 281 amino acids; 31642 Da
Subunit: Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1,
RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65 (By similarity)
Secondary accessions: B2R709 B4DFF4 Q9NYB4
Alternative splicing: 2 isoforms:  Q9Y272-1   Q9Y272-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RASD1: NX_Q9Y272

Explore proteomics data for RASD1 at MOPED

Post-translational modifications: 

  • S-nitrosylation stimulates guanine-nucleotide exchange activity1
  • Modification sites at neXtProt

  • See RASD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186918.1  NP_057168.1  

    ENSEMBL proteins: 
     ENSP00000225688   ENSP00000463388  

    RASD1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RASD1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q9Y272

    ProtoNet protein and cluster: Q9Y272

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RASD1_HUMAN, Q9Y272
    Similarity: Belongs to the small GTPase superfamily. RasD family


    Find genes that share domains with RASD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASD1_HUMAN, Q9Y272
    Function: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex
    via its interaction with APBB1/FE65 (By similarity)
    Induction: By dexamethasone

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS10471929
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RASD1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rasd1):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with RASD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RASD1: Rasd1tm1Pngr Rasd1tm1.1Snyd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASD1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASD1

    miRNA
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    miRTarBase miRNAs that target RASD1:
    hsa-mir-375 (MIRT004439), hsa-mir-335-5p (MIRT018256)

    Block miRNA regulation of human, mouse, rat RASD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASD1 (see all 26):
    hsa-miR-30c hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-375
    SwitchGear 3'UTR luciferase reporter plasmidRASD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RASD1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): RASD1 (NM_016084)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RASD1_HUMAN, Q9Y272: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, perinuclear region (By
    similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    golgi apparatus2
    nucleus2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with RASD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RASD1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Circadian entrainment0.40
    2MAPK targets/ Nuclear events mediated by MAP kinases
    MAP Kinase Signaling0.31
    3Selected targets of GCR alpha
    Selected targets of GCR alpha
    4Selected targets of ESR1
    Selected targets of ESR1
    5nNOS Signaling at Neuronal Synapses
    nNOS Signaling at Neuronal Synapses


    Find genes that share SuperPaths with RASD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RASD1
        nNOS Signaling at Neuronal Synapses

    2 Cell Signaling Technology (CST) Pathways for RASD1
        MAP Kinase Signaling
    Neuroscience


    1 Kegg Pathway  (Kegg details for RASD1):
        Circadian entrainment

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RASD1: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Neurotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RASD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RASD1 (Q9Y2722, 3 ENSP000002256884) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLSCR1O151622, 3, ENSP000003454944MINT-66109 I2D: score=5 STRING: ENSP00000345494
    NOS1P294753, ENSP000003207584I2D: score=2 STRING: ENSP00000320758
    GNB1P628733, ENSP000003678724I2D: score=1 STRING: ENSP00000367872
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction TAS10471929
    GO:0007186G-protein coupled receptor signaling pathway TAS10840027

    Find genes that share ontologies with RASD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASD1

    3 Novoseek inferred chemical compound relationships for RASD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dexamethasone 31.8 5 9452419 (2), 11356714 (1), 10467249 (1)
    gtp 31.8 1 11356714 (1)
    steroid 9.25 1 15020218 (1)



    Find genes that share compounds with RASD1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RASD1 gene (2 alternative transcripts): 
    NM_001199989.1  NM_016084.4  

    Unigene Cluster for RASD1:

    RAS, dexamethasone-induced 1
    Hs.25829  [show with all ESTs]
    Unigene Representative Sequence: NM_016084
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225688(uc002gri.3 uc021trg.1) ENST00000579152
    miRNA
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    Block miRNA regulation of human, mouse, rat RASD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASD1 (see all 26):
    hsa-miR-30c hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-375
    SwitchGear 3'UTR luciferase reporter plasmidRASD1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RASD1
      QuantiFast Probe-based Assays in human, mouse, rat RASD1

    Additional mRNA sequence: 

    AF069506.1 AF153192.1 AF172846.1 AF177335.1 AF498923.1 AK294073.1 AK312796.1 BC018041.1 
    BC042688.1 

    2 DOTS entries:

    DT.210789  DT.120953287 

    Selected AceView cDNA sequences (see all 178):

    BI759201 BI823596 BM543630 CD513372 BM311047 BM921737 CD676181 BF057610 
    AF498923 CB217058 CD251380 CR596563 CA390264 CD513046 BI596637 AI589181 
    BG654362 BG913727 BM921656 AI560148 BQ719566 AI197818 AI623091 AI564109 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACACGAACA
    RASD1 Expression
    About this image


    RASD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Body Subcutaneous White Adipose
             HyStem+BMP4-induced 7SMOO32 cells
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced MEL2 cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    RASD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25829

    UniProtKB/Swiss-Prot: RASD1_HUMAN, Q9Y272
    Tissue specificity: Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta,
    lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RASD1: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Neurotoxicity in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RASD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASD1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasd11 , 5 RAS, dexamethasone-induced 11, 5 88.33(n)1
    96.79(a)1
      11 (37.81 cM)5
    194161  NM_009026.41  NP_033052.11 
     599631815 
    chicken
    (Gallus gallus)
    Aves RASD11 RAS, dexamethasone-induced 1 87.77(n)
    88.13(a)
      416507  NM_001044636.1  NP_001038101.1 
    lizard
    (Anolis carolinensis)
    Reptilia RASD16
    RAS, dexamethasone-induced 1
    88(a)
    1 ↔ 1
    GL343500.1(284513-288012)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.215622 Xenopus laevis ras-related protein mRNA, partial cds 79.02(n)    AF170335.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc659092 hypothetical protein MGC65909 78.73(n)   393504  BC056272.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86411 , 3 RAS small monomeric GTPase3
    CG86411
    49(a)
    (best of 2)3
    56.82(n)1
    52.23(a)1
      65E33
    387711  NM_139816.21  NP_648073.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ssr-26
    Protein SSR-2 (ssr-2) mRNA, complete cds
    25(a)
    many ↔ many
    X(2823500-2826827) WBGene00006055


    ENSEMBL Gene Tree for RASD1 (if available)
    TreeFam Gene Tree for RASD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASD1 gene
    RAP2C2  RASL10B2  DIRAS12  RAP1B2  RASD22  RIT22  RAP2A2  RIT12  
    RAP1A2  RAP2B2  DIRAS22  RASL10A2  DIRAS32  
    17 SIMAP similar genes for RASD1 using alignment to 1 protein entry:     RASD1_HUMAN:
    RASD2    DIRAS1    DKFZp547A0616    RANP1    RAP2B    RAP2C
    RAP1A    RAP1B    RAP2A    NRAS    DIRAS2    RRAS2
    RALA    MRAS    RIT1    RALB    RERG

    Find genes that share paralogs with RASD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASD1 (see all 112)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443146371,2
    --17384912(+) CCCACA/GCTGAG 2 -- int10--------
    rs1156127701,2
    C,F--17384959(+) TTTTAC/AGCTGA 2 -- int13Minor allele frequency- A:0.08WA NA EA 358
    rs1843849181,2
    --17384960(+) TTTACA/GCTGAA 2 -- int10--------
    rs49248681,2
    C,A,H--17385062(+) AGGGGG/AGACCC 2 -- int110Minor allele frequency- A:0.41NA CSA WA EA 372
    rs1884322141,2
    --17385148(+) CTGGCA/GGCTGA 2 -- int10--------
    rs129383871,2
    C--17385270(+) CATCTC/TTAAAA 2 -- int12Minor allele frequency- T:0.25NA 4
    rs739789381,2
    C--17385277(+) AAAAGA/CAAAAA 2 -- int11Minor allele frequency- C:0.00WA 2
    rs7113521,2
    C,F,A,H--17385368(-) TGTGTG/CTGAGG 2 -- ut31 ese315Minor allele frequency- C:0.44NS EA MN NA WA CSA 957
    rs1130656591,2
    C,F--17385423(+) ACACCG/AGAACT 2 -- ut311Minor allele frequency- A:0.50CSA 2
    rs16718231,2
    F--17385455(+) TTTTGT/GGTTCC 2 -- ut31 ese31Minor allele frequency- G:0.05MN 184

    HapMap Linkage Disequilibrium report for RASD1 (17397751 - 17399709 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RASD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv907730CNV Loss21882294
    dgv3068n71CNV Loss21882294
    nsv907731CNV Loss21882294
    nsv907729CNV Loss21882294
    dgv3067n71CNV Loss21882294
    nsv907737CNV Loss21882294
    nsv155OTHER Inversion15895083
    nsv499114OTHER Inversion21111241

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605550    OMIM disorders: --

    2 diseases for RASD1:    
    About MalaCards
    myeloma    multiple myeloma


    Find genes that share disorders with RASD1           About GenesLikeMe

    1 Novoseek inferred disease relationship for RASD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 10234739 (1)

    Human Genome Epidemiology (HuGE) Navigator: RASD1 (1 document)

    Export disorders for RASD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for RASD1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with RASD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a glucocorticoid response element in the 3'- flanking region of the human Dexras1 gene. (PubMed id 12818426)1, 2, 9 Kemppainen R.J.... Ammons J.M. (Biochim. Biophys. Acta 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue. (PubMed id 12498886)1, 2 Jaffrey S.R.... Snyder S.H. (Chem. Biol. 2002)
    4. Genes expressed in human tumor endothelium. (PubMed id 10947988)1, 3 St Croix B....Kinzler K.W. (Science 2000)
    5. Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone. (PubMed id 10673050)1, 2 Tu Y. and Wu C. (Biochim. Biophys. Acta 1999)
    6. Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling. (PubMed id 10471929)1, 2 Cismowski M.J.... Duzic E. (Nat. Biotechnol. 1999)
    7. Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling. (PubMed id 16489124)1, 9 Nguyen C.H. and Watts V.J. (Mol. Pharmacol. 2006)
    8. Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes. (PubMed id 11842095)1, 9 Takesono A....Lanier S.M. (J. Biol. Chem. 2002)
    9. Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells. (PubMed id 9452419)1, 9 Kemppainen R.J. and Behrend E.N. (J. Biol. Chem. 1998)
    10. Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription. (PubMed id 21247419)1 Tan J.J....Chen K.S. (BMC Mol. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 51655 HGNC: 15828 AceView: RASD1 Ensembl:ENSG00000108551 euGenes: HUgn51655
    ECgene: RASD1 Kegg: 51655 H-InvDB: RASD1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RASD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RASD1 gene:
    Search GeneIP for patents involving RASD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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