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Aliases for RASAL3 Gene

Aliases for RASAL3 Gene

  • RAS Protein Activator Like 3 2 3 5

External Ids for RASAL3 Gene

Previous GeneCards Identifiers for RASAL3 Gene

  • GC19M015426
  • GC19M015562
  • GC19M015132

Summaries for RASAL3 Gene

GeneCards Summary for RASAL3 Gene

RASAL3 (RAS Protein Activator Like 3) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by PTK6. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RASAL1.

UniProtKB/Swiss-Prot for RASAL3 Gene

  • Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASAL3 Gene

Genomics for RASAL3 Gene

Regulatory Elements for RASAL3 Gene

Enhancers for RASAL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RASAL3 on UCSC Golden Path with GeneCards custom track

Promoters for RASAL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASAL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASAL3 Gene

15,451,624 bp from pter
15,464,571 bp from pter
12,948 bases
Minus strand

Genomic View for RASAL3 Gene

Genes around RASAL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASAL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASAL3 Gene

Proteins for RASAL3 Gene

  • Protein details for RASAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RAS protein activator like-3
    Protein Accession:
    Secondary Accessions:
    • Q8N2T9
    • Q9H735

    Protein attributes for RASAL3 Gene

    1011 amino acids
    Molecular mass:
    111898 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30281.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15064.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC56928.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC56928.1; Type=Erroneous termination; Positions=723; Note=Translated as Arg.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASAL3 Gene


neXtProt entry for RASAL3 Gene

Proteomics data for RASAL3 Gene at MOPED

Post-translational modifications for RASAL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASAL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASAL3 Gene

Domains & Families for RASAL3 Gene

Gene Families for RASAL3 Gene

Suggested Antigen Peptide Sequences for RASAL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
  • Contains 1 PH domain.
  • Contains 1 Ras-GAP domain.
genes like me logo Genes that share domains with RASAL3: view

Function for RASAL3 Gene

Molecular function for RASAL3 Gene

UniProtKB/Swiss-Prot Function:
Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway.

Phenotypes for RASAL3 Gene

GenomeRNAi human phenotypes for RASAL3:
genes like me logo Genes that share phenotypes with RASAL3: view

Animal Model Products

miRNA for RASAL3 Gene

miRTarBase miRNAs that target RASAL3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASAL3 Gene

Localization for RASAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASAL3 Gene

Cytoplasm. Cytoplasm, cell cortex.

Subcellular locations from

Jensen Localization Image for RASAL3 Gene COMPARTMENTS Subcellular localization image for RASAL3 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 4
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RASAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 25652366
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RASAL3: view

Pathways & Interactions for RASAL3 Gene

SuperPathways for RASAL3 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Developmental Biology
3 Immune System
4 Signaling by PTK6
5 Signaling by GPCR
genes like me logo Genes that share pathways with RASAL3: view

Pathways by source for RASAL3 Gene

Gene Ontology (GO) - Biological Process for RASAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0007165 signal transduction IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RASAL3: view

No data available for SIGNOR curated interactions for RASAL3 Gene

Drugs & Compounds for RASAL3 Gene

No Compound Related Data Available

Transcripts for RASAL3 Gene

Unigene Clusters for RASAL3 Gene

RAS protein activator like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASAL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b
SP3: - -
SP5: - - -
SP9: -

Relevant External Links for RASAL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASAL3 Gene

mRNA expression in normal human tissues for RASAL3 Gene

mRNA differential expression in normal tissues according to GTEx for RASAL3 Gene

This gene is overexpressed in Whole Blood (x17.0), Spleen (x7.6), and Small Intestine - Terminal Ileum (x4.6).

Protein differential expression in normal tissues from HIPED for RASAL3 Gene

This gene is overexpressed in Tlymphocyte (26.0), Peripheral blood mononuclear cells (19.3), NK cells (8.6), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASAL3 Gene

SOURCE GeneReport for Unigene cluster for RASAL3 Gene Hs.136979

mRNA Expression by UniProt/SwissProt for RASAL3 Gene

Tissue specificity: Predominantly expressed in cells of hematopoietic lineages.
genes like me logo Genes that share expression patterns with RASAL3: view

Protein tissue co-expression partners for RASAL3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RASAL3 Gene

Orthologs for RASAL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASAL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASAL3 35
  • 83.75 (n)
  • 83.91 (a)
  • 84 (a)
(Canis familiaris)
Mammalia RASAL3 35
  • 85.87 (n)
  • 85.35 (a)
  • 79 (a)
(Mus musculus)
Mammalia Rasal3 35
  • 80.17 (n)
  • 80.7 (a)
Rasal3 16
Rasal3 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Rasal3 35
  • 79.74 (n)
  • 80.24 (a)
(Monodelphis domestica)
Mammalia RASAL3 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia RASAL3 36
  • 59 (a)
(Gallus gallus)
Aves RASAL3 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasal3 35
  • 50.33 (n)
  • 43.42 (a)
(Danio rerio)
Actinopterygii rasal3 36
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42684 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea gap-2 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD2 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6146 36
  • 23 (a)
Species with no ortholog for RASAL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASAL3 Gene

Gene Tree for RASAL3 (if available)
Gene Tree for RASAL3 (if available)

Paralogs for RASAL3 Gene

Paralogs for RASAL3 Gene

(4) SIMAP similar genes for RASAL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RASAL3: view

Variants for RASAL3 Gene

Sequence variations from dbSNP and Humsavar for RASAL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs58123634 - 15,458,567(+) GTGCA(C/G)TGGCC nc-transcript-variant, reference, missense
rs56209154 - 15,454,835(+) GCCAC(A/G)TTCTT nc-transcript-variant, reference, missense
rs57208996 - 15,453,304(+) GGCAG(G/T)ACGCC nc-transcript-variant, reference, missense
rs7256157 -- 15,455,000(+) TGATC(C/G)TCCAG intron-variant
rs8103671 -- 15,465,580(+) tctgt(C/G)tccca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RASAL3 Gene

Variant ID Type Subtype PubMed ID
nsv833765 CNV Loss 17160897
nsv911133 CNV Loss 21882294
dgv3746n71 CNV Loss 21882294
dgv3747n71 CNV Loss 21882294
nsv482216 CNV Loss 20164927
esv2551856 CNV Deletion 19546169

Variation tolerance for RASAL3 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RASAL3 Gene

Disorders for RASAL3 Gene

Relevant External Links for RASAL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RASAL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASAL3 Gene

Publications for RASAL3 Gene

  1. RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells. (PMID: 25652366) Saito S. … Fujii M. (Eur. J. Immunol. 2015) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3
  4. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. (PMID: 20458337) Buschow S.I. … Stoorvogel W. (Immunol. Cell Biol. 2010) 3
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3

Products for RASAL3 Gene

Sources for RASAL3 Gene