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Aliases for RASAL3 Gene

Aliases for RASAL3 Gene

  • RAS Protein Activator Like 3 2 3

External Ids for RASAL3 Gene

Summaries for RASAL3 Gene

GeneCards Summary for RASAL3 Gene

RASAL3 (RAS Protein Activator Like 3) is a Protein Coding gene. Among its related pathways are Ras signaling pathway. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is RASA2.

UniProtKB/Swiss-Prot for RASAL3 Gene

  • May function as a Ras GTPase-activating protein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASAL3 Gene

Genomics for RASAL3 Gene

Genomic Location for RASAL3 Gene

Start:
15,451,624 bp from pter
End:
15,464,571 bp from pter
Size:
12,948 bases
Orientation:
Minus strand

Genomic View for RASAL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASAL3 Gene

Regulatory Elements for RASAL3 Gene

Proteins for RASAL3 Gene

  • Protein details for RASAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YV0-RASL3_HUMAN
    Recommended name:
    RAS protein activator like-3
    Protein Accession:
    Q86YV0
    Secondary Accessions:
    • Q8N2T9
    • Q9H735

    Protein attributes for RASAL3 Gene

    Size:
    1011 amino acids
    Molecular mass:
    111898 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30281.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15064.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC56928.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC56928.1; Type=Erroneous termination; Positions=723; Note=Translated as Arg.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASAL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASAL3 Gene

Proteomics data for RASAL3 Gene at MOPED

Post-translational modifications for RASAL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASAL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASAL3 Gene

Domains for RASAL3 Gene

UniProtKB/Swiss-Prot:

RASL3_HUMAN
Domain:
  • Contains 1 C2 domain.:
    • Q86YV0
  • Contains 1 PH domain.:
    • Q86YV0
  • Contains 1 Ras-GAP domain.:
    • Q86YV0
genes like me logo Genes that share domains with RASAL3: view

No data available for Gene Families for RASAL3 Gene

Function for RASAL3 Gene

Molecular function for RASAL3 Gene

UniProtKB/Swiss-Prot Function: May function as a Ras GTPase-activating protein.

Gene Ontology (GO) - Molecular Function for RASAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RASAL3: view

miRNA for RASAL3 Gene

miRTarBase miRNAs that target RASAL3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RASAL3 Gene

Localization for RASAL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASAL3 Gene COMPARTMENTS Subcellular localization image for RASAL3 gene
Compartment Confidence
cytosol 3
plasma membrane 3
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RASAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RASAL3: view

Pathways for RASAL3 Gene

SuperPathways for RASAL3 Gene

Superpath Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with RASAL3: view

Pathways by source for RASAL3 Gene

1 KEGG pathway for RASAL3 Gene

Gene Ontology (GO) - Biological Process for RASAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0046580 negative regulation of Ras protein signal transduction IBA --
genes like me logo Genes that share ontologies with RASAL3: view

Transcripts for RASAL3 Gene

Unigene Clusters for RASAL3 Gene

RAS protein activator like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASAL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b
SP1:
SP2:
SP3: - -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9: -
SP10:

Relevant External Links for RASAL3 Gene

GeneLoc Exon Structure for
RASAL3
ECgene alternative splicing isoforms for
RASAL3

Expression for RASAL3 Gene

mRNA expression in normal human tissues for RASAL3 Gene

mRNA differential expression in normal tissues according to GTEx for RASAL3 Gene

This gene is overexpressed in Whole Blood (17.0), Spleen (7.6), and Small Intestine - Terminal Ileum (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASAL3 Gene

SOURCE GeneReport for Unigene cluster for RASAL3 Gene Hs.136979

genes like me logo Genes that share expressions with RASAL3: view

Orthologs for RASAL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASAL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASAL3 36
  • 83.75 (n)
  • 83.91 (a)
RASAL3 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASAL3 36
  • 85.87 (n)
  • 85.35 (a)
RASAL3 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasal3 36
  • 80.17 (n)
  • 80.7 (a)
Rasal3 16
Rasal3 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASAL3 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASAL3 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasal3 36
  • 79.74 (n)
  • 80.24 (a)
chicken
(Gallus gallus)
Aves RASAL3 37
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 30 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rasal3 36
  • 50.33 (n)
  • 43.42 (a)
zebrafish
(Danio rerio)
Actinopterygii rasal3 37
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42684 37
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gap-2 37
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD2 37
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6146 37
  • 23 (a)
OneToMany
Species with no ortholog for RASAL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASAL3 Gene

ENSEMBL:
Gene Tree for RASAL3 (if available)
TreeFam:
Gene Tree for RASAL3 (if available)

Paralogs for RASAL3 Gene

Paralogs for RASAL3 Gene

Selected SIMAP similar genes for RASAL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RASAL3: view

Variants for RASAL3 Gene

Sequence variations from dbSNP and Humsavar for RASAL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12462462 -- 15,454,415(+) AACTG(C/G)AGGGC reference, synonymous-codon, nc-transcript-variant
rs11882108 -- 15,462,844(+) tgctc(A/G)ggagg intron-variant
rs11672335 -- 15,455,147(+) CAATC(A/G/T)CTGGG intron-variant
rs11666779 -- 15,464,990(+) ccaca(C/T)tggaa upstream-variant-2KB
rs10410954 -- 15,466,311(+) TTAGC(A/G)TGttc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RASAL3 Gene

Variant ID Type Subtype PubMed ID
nsv833765 CNV Loss 17160897
nsv911133 CNV Loss 21882294
dgv3746n71 CNV Loss 21882294
dgv3747n71 CNV Loss 21882294
nsv482216 CNV Loss 20164927
esv2551856 CNV Deletion 19546169

Relevant External Links for RASAL3 Gene

HapMap Linkage Disequilibrium report
RASAL3

Disorders for RASAL3 Gene

No disorders were found for RASAL3 Gene.

No data available for UniProtKB/Swiss-Prot for RASAL3 Gene

Publications for RASAL3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3
  5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. (PMID: 20458337) Buschow S.I. … Stoorvogel W. (Immunol. Cell Biol. 2010) 3

Products for RASAL3 Gene

Sources for RASAL3 Gene

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