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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASAL3 Gene

protein-coding   GIFtS: 44
GCID: GC19M015562

RAS protein activator like 3

 Explore 1 disease affiliated with
RASAL3 via our new
 Human Malady Compendium 
Biological research products
for RASAL3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RAS Protein Activator Like 31 2
FLJ214381
RAS Protein Activator Like-32

External Ids:    HGNC: 261291   Entrez Gene: 649262   Ensembl: ENSG000001051227   UniProtKB: Q86YV03   

Export aliases for RASAL3 gene to outside databases

Previous GC identifers: GC19M015426 GC19M015132


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RASL3_HUMAN, Q86YV0
Function: May function as a Ras GTPase-activating protein (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASAL3 gene promoter:
         GR   CP2   Sp1   AP-1   GR-beta   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RASAL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASAL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

RASAL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASAL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M015562:  view genomic region     (about GC identifiers)

Start:
15,562,438 bp from pter      End:
15,575,382 bp from pter
Size:
12,945 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RASL3_HUMAN, Q86YV0 (See protein sequence)
Recommended Name: RAS protein activator like-3  
Size: 1011 amino acids; 111898 Da
Sequence caution: Sequence=AAH30281.1; Type=Erroneous initiation; Sequence=BAB15064.1; Type=Erroneous initiation;
Sequence=BAC56928.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC56928.1;
Type=Erroneous termination; Positions=723; Note=Translated as Arg;
Secondary accessions: Q8N2T9 Q9H735
Alternative splicing: 2 isoforms:  Q86YV0-1   Q86YV0-2   

Explore the universe of human proteins at neXtProt for RASAL3: NX_Q86YV0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86YV0

  • RASAL3 Protein expression data from MOPED and PaxDb:    About this image 
    RASAL3 Protein Expression
    REFSEQ proteins: NP_075055.1  
    ENSEMBL proteins: 
     ENSP00000341905  

    Human Recombinant Protein Products for RASAL3: 
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    Uscn Proteins for RASAL3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0031235intrinsic to internal side of plasma membrane IBA--

    RASAL3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RASAL3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RASAL3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR023152 RasGAP_CS
     IPR008973 C2_Ca/lipid-bd_dom_CaLB

    Graphical View of Domain Structure for InterPro Entry Q86YV0

    ProtoNet protein and cluster: Q86YV0

    3 Blocks protein families:
    IPB000008 C2 domain
    IPB001849 Pleckstrin-like
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: RASL3_HUMAN, Q86YV0
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASL3_HUMAN, Q86YV0
    Function: May function as a Ras GTPase-activating protein (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005099Ras GTPase activator activity IBA--
    GO:0005543phospholipid binding IEA--
         
    RASAL3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RASAL3 

    miRNA
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    In Situ Assay
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASAL3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for RASAL3 (Q86YV03 ENSP000003419054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    APCP250543I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0032320positive regulation of Ras GTPase activity IBA--
    GO:0046580negative regulation of Ras protein signal transduction IBA--

    RASAL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RASAL3
    Search CenterWatch for drugs/clinical trials and news about RASAL3 / RASL3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RASAL3 gene: 
    NM_022904.1  

    Unigene Cluster for RASAL3:

    RAS protein activator like 3
    Hs.136979  [show with all ESTs]
    Unigene Representative Sequence: AK024488
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000343625(uc002nbd.3 uc002nbe.2)

    miRNA
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK024488.1 AK025091.1 AK122587.1 AL832868.1 BC030281.1 

    5 DOTS entries:

    DT.429889  DT.92011570  DT.97839526  DT.100711746  DT.40194796 

    24/67 AceView cDNA sequences (see all 67):

    AI697316 AA767936 AK122587 AW661927 BC030281 BX109514 BQ052406 AI028474 
    AK024488 AA359127 AW440942 BX644896 AL832868 CR595796 AI364659 BU430749 
    AA320236 BE831113 CA307701 BG758542 BX363502 BX372309 CF135868 BM922942 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RASAL3 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b
    SP1:                                                                                                                                                
    SP2:                                                                                                                                                
    SP3:                                                                                                                    -     -                     
    SP4:                                                                                                                                                
    SP5:                                                                                                                    -     -     -               


    ECgene alternative splicing isoforms for RASAL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASAL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGACCAGCGC
    RASAL3 Expression
    About this image

    RASAL3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RASAL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASAL3

    SOURCE GeneReport for Unigene cluster: Hs.136979
        SABiosciences Custom PCR Arrays for RASAL3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASAL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RASAL3 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia DAB2IP6
    --
    30(a)
    1 ↔ 1
    2(79737272-79771388)
    zebrafish
    (Danio rerio)
    Actinopterygii rasal36
    RAS protein activator like 3
    25(a)
    1 ↔ 1
    6(9306393-9325605)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG426846
    --
    11(a)
    1 → many
    X(17604178-17645718)
    worm
    (Caenorhabditis elegans)
    Secernentea gap-26
    Ras GTPase-activating protein gap-2
    16(a)
    1 → many
    X(9472410-9516378)


    ENSEMBL Gene Tree for RASAL3 (if available)
    TreeFam Gene Tree for RASAL3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASAL3 gene
    SYNGAP12  DAB2IP2  RASA42  RASA12  RASA22  RASA4B2  RASAL22  RASA32  
    RASAL12  
    4 SIMAP similar genes for RASAL3 using alignment to 2 protein entries:     RASL3_HUMAN (see all proteins):
    FLJ00087    DAB2IP    RASAL2    SYNGAP1

    RASAL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/214 NCBI SNPs in RASAL3 are shown (see all 214    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs772754681,2
    C--15562784(+) AACCAG/AGAGAG 1 -- int12Minor allele frequency- A:0.02CSA WA 120
    rs2021580141,2
    --15562798(+) TGCACC/TGCAAC 1 -- int10--------
    rs2013035291,2
    --15562833(+) TGCCCC/GAGGGC 1 -- int10--------
    rs1385031061,2
    C--15562844(+) TCAGAC/TGGCAA 1 -- int10--------
    rs2002333611,2
    --15562934(+) TCGGGA/GGATTG 1 -- int10--------
    rs23042011,2
    C--15563391(-) CCCCCC/TCCCCA 1 -- int1 trp30--------
    rs1141348791,2
    C--15563460(+) AGGGCT/CGGGCT 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1997374551,2
    C--15563513(+) CGCAGC/TTGCTC 2 Q syn10--------
    rs1925218921,2
    --15563601(+) GAGCGA/GCCACC 2 A V mis10--------
    rs126101181,2
    C,H--15563823(+) gcgagC/Atgggt 1 -- int15Minor allele frequency- A:0.00NS EA NA 420

    HapMap Linkage Disequilibrium report for RASAL3 (15562438 - 15575382 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RASAL3
         1 Indel: 102793

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RASAL3 for disorders           About GeneDecksing

    1 disease for RASAL3:    About MalaCards
    neuronitis


    Export disorders for RASAL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASAL3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RASAL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64926 HGNC: 26129 AceView: FLJ21438 Ensembl:ENSG00000105122 euGenes: HUgn64926
    ECgene: RASAL3 H-InvDB: RASAL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASAL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RASAL3 gene:
    Search GeneIP for patents involving RASAL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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