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Aliases for RASAL2 Gene

Aliases for RASAL2 Gene

  • RAS Protein Activator Like 2 2 3 5
  • RAS Protein Activator Like 1 2 3
  • NGAP 3 4
  • Ras GTPase Activating Protein-Like 2
  • Ras GTPase-Activating Protein NGAP 3
  • RAS Protein Activator-Like 2 4

External Ids for RASAL2 Gene

Previous GeneCards Identifiers for RASAL2 Gene

  • GC01P175834
  • GC01P173491
  • GC01P174643
  • GC01P175303
  • GC01P174795
  • GC01P176329
  • GC01P149291

Summaries for RASAL2 Gene

Entrez Gene Summary for RASAL2 Gene

  • This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASAL2 Gene

RASAL2 (RAS Protein Activator Like 2) is a Protein Coding gene. Among its related pathways are RET signaling and Immune System. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is DAB2IP.

UniProtKB/Swiss-Prot for RASAL2 Gene

  • Inhibitory regulator of the Ras-cyclic AMP pathway.

Gene Wiki entry for RASAL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASAL2 Gene

Genomics for RASAL2 Gene

Regulatory Elements for RASAL2 Gene

Enhancers for RASAL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F178072 0.6 FANTOM5 21 -21.1 -21149 0.3 RASAL2 RASAL2-AS1 ENSG00000254154 SEC16B LOC730102
GH01F178054 0.9 Ensembl ENCODE 20.8 -36.7 -36729 4.4 HDGF ARID4B DMAP1 ZNF48 YY1 DEK MIER2 TSHZ1 TBX21 PPARG RASAL2 RASAL2-AS1 SEC16B LOC730102 ENSG00000254154
GH01F178124 0.8 Ensembl ENCODE 18.4 +33.3 33327 4.5 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A ZNF48 YY1 SLC30A9 GLIS2 KLF7 RASAL2-AS1 RASAL2 LOC105371630 GC01M178037
GH01F178155 0.4 ENCODE 16.4 +62.7 62681 2.6 SAP130 SIN3A ZNF384 DNMT3B KMT2B ZNF600 MAFK ZNF362 HLF BHLHE40 RASAL2-AS1 RASAL2 GC01M178037 LOC105371630
GH01F178051 1 Ensembl ENCODE 11.8 -41.1 -41147 3.2 ATF1 ZFP64 ARID4B DMAP1 YY1 SP5 MXD4 TBX21 PPARG KAT8 RASAL2 RASAL2-AS1 ENSG00000254154 LOC730102
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RASAL2 on UCSC Golden Path with GeneCards custom track

Promoters for RASAL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000548251 1271 4401 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 DEK ZNF263 SP3

Genomic Location for RASAL2 Gene

Chromosome:
1
Start:
178,093,729 bp from pter
End:
178,484,147 bp from pter
Size:
390,419 bases
Orientation:
Plus strand

Genomic View for RASAL2 Gene

Genes around RASAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASAL2 Gene

Proteins for RASAL2 Gene

  • Protein details for RASAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJF2-NGAP_HUMAN
    Recommended name:
    Ras GTPase-activating protein nGAP
    Protein Accession:
    Q9UJF2
    Secondary Accessions:
    • F8W755
    • O95174
    • Q2TB22
    • Q5TFU9

    Protein attributes for RASAL2 Gene

    Size:
    1139 amino acids
    Molecular mass:
    128558 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI10612.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASAL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASAL2 Gene

Post-translational modifications for RASAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RASAL2 (RASAL2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for RASAL2

No data available for DME Specific Peptides for RASAL2 Gene

Domains & Families for RASAL2 Gene

Suggested Antigen Peptide Sequences for RASAL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJF2

UniProtKB/Swiss-Prot:

NGAP_HUMAN :
  • Contains 1 C2 domain.
Domain:
  • Contains 1 C2 domain.
  • Contains 1 PH domain.
  • Contains 1 Ras-GAP domain.
genes like me logo Genes that share domains with RASAL2: view

Function for RASAL2 Gene

Molecular function for RASAL2 Gene

UniProtKB/Swiss-Prot Function:
Inhibitory regulator of the Ras-cyclic AMP pathway.

Gene Ontology (GO) - Molecular Function for RASAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA,TAS --
GO:0005515 protein binding IPI 18985028
genes like me logo Genes that share ontologies with RASAL2: view
genes like me logo Genes that share phenotypes with RASAL2: view

Animal Models for RASAL2 Gene

MGI Knock Outs for RASAL2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASAL2 Gene

Localization for RASAL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASAL2 Gene COMPARTMENTS Subcellular localization image for RASAL2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2

Gene Ontology (GO) - Cellular Components for RASAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA --
genes like me logo Genes that share ontologies with RASAL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASAL2 Gene

Pathways & Interactions for RASAL2 Gene

SuperPathways for RASAL2 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 HIV Life Cycle
.45
5 Immune System
genes like me logo Genes that share pathways with RASAL2: view

Pathways by source for RASAL2 Gene

1 Cell Signaling Technology pathway for RASAL2 Gene
1 KEGG pathway for RASAL2 Gene

Gene Ontology (GO) - Biological Process for RASAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction IEA,TAS 9877179
GO:0043087 regulation of GTPase activity IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0046580 negative regulation of Ras protein signal transduction IBA --
genes like me logo Genes that share ontologies with RASAL2: view

No data available for SIGNOR curated interactions for RASAL2 Gene

Transcripts for RASAL2 Gene

mRNA/cDNA for RASAL2 Gene

(12) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASAL2 Gene

RAS protein activator like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASAL2 Gene

No ASD Table

Relevant External Links for RASAL2 Gene

GeneLoc Exon Structure for
RASAL2
ECgene alternative splicing isoforms for
RASAL2

Expression for RASAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RASAL2 Gene

This gene is overexpressed in Synovial fluid (13.9), Milk (11.6), and Uterus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RASAL2 Gene



NURSA nuclear receptor signaling pathways regulating expression of RASAL2 Gene:

RASAL2

SOURCE GeneReport for Unigene cluster for RASAL2 Gene:

Hs.496139
genes like me logo Genes that share expression patterns with RASAL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RASAL2 Gene

Orthologs for RASAL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASAL2 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia RASAL2 34 35
  • 94.17 (n)
oppossum
(Monodelphis domestica)
Mammalia RASAL2 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasal2 34 16 35
  • 92.78 (n)
cow
(Bos Taurus)
Mammalia RASAL2 34 35
  • 92.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RASAL2 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASAL2 34 35
  • 81.56 (n)
lizard
(Anolis carolinensis)
Reptilia RASAL2 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasal2 34
  • 76.45 (n)
Str.11362 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1575 34
zebrafish
(Danio rerio)
Actinopterygii rasal2 34 35
  • 70.89 (n)
Dr.24417 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7799 34
fruit fly
(Drosophila melanogaster)
Insecta CG42684 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gap-2 36 35
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD2 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6146 35
  • 35 (a)
OneToMany
Species where no ortholog for RASAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASAL2 Gene

ENSEMBL:
Gene Tree for RASAL2 (if available)
TreeFam:
Gene Tree for RASAL2 (if available)

Paralogs for RASAL2 Gene

Paralogs for RASAL2 Gene

(4) SIMAP similar genes for RASAL2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RASAL2: view

Variants for RASAL2 Gene

Sequence variations from dbSNP and Humsavar for RASAL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs765646105 A colorectal cancer sample 178,442,684(+) ATTGC(A/T)GGCGA reference, missense
VAR_035542 A breast cancer sample
rs193921085 Uncertain significance 178,473,216(+) ATGGT(G/T)AATTC reference, stop-gained, stop-lost
rs10047058 -- 178,173,039(+) CCTAT(A/G)TGCAT intron-variant
rs10047059 -- 178,173,061(+) CGTTT(G/T)TCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASAL2 Gene

Variant ID Type Subtype PubMed ID
esv2534493 CNV deletion 19546169
esv2606666 CNV deletion 19546169
esv3416886 CNV duplication 20981092
esv3588029 CNV loss 21293372
esv3588030 CNV loss 21293372
esv3588031 CNV loss 21293372
esv3588032 CNV loss 21293372
esv3588033 CNV loss 21293372
nsv1142076 CNV tandem duplication 24896259
nsv473443 CNV novel sequence insertion 20440878
nsv508670 CNV deletion 20534489
nsv548252 CNV gain 21841781
nsv946518 CNV duplication 23825009

Variation tolerance for RASAL2 Gene

Residual Variation Intolerance Score: 5.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASAL2 Gene

Disorders for RASAL2 Gene

Relevant External Links for RASAL2

Genetic Association Database (GAD)
RASAL2
Human Genome Epidemiology (HuGE) Navigator
RASAL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASAL2

No disorders were found for RASAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASAL2 Gene

Publications for RASAL2 Gene

  1. A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25. (PMID: 9877179) Noto S. … Hatakeyama M. (FEBS Lett. 1998) 2 3 4 64
  2. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) MelAcn E. … Lasky-Su J. (J. Allergy Clin. Immunol. 2010) 3 46 64
  3. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 46 64
  4. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (PMID: 19079260) Thorleifsson G. … Stefansson K. (Nat. Genet. 2009) 3 46 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for RASAL2 Gene

Sources for RASAL2 Gene

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