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Aliases for RASAL2 Gene

Aliases for RASAL2 Gene

  • RAS Protein Activator Like 2 2 3 5
  • RAS Protein Activator Like 1 2 3
  • NGAP 3 4
  • Ras GTPase Activating Protein-Like 2
  • Ras GTPase-Activating Protein NGAP 3
  • RAS Protein Activator-Like 2 4

External Ids for RASAL2 Gene

Previous GeneCards Identifiers for RASAL2 Gene

  • GC01P175834
  • GC01P173491
  • GC01P174643
  • GC01P175303
  • GC01P174795
  • GC01P176329
  • GC01P149291

Summaries for RASAL2 Gene

Entrez Gene Summary for RASAL2 Gene

  • This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASAL2 Gene

RASAL2 (RAS Protein Activator Like 2) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is DAB2IP.

UniProtKB/Swiss-Prot for RASAL2 Gene

  • Inhibitory regulator of the Ras-cyclic AMP pathway.

Gene Wiki entry for RASAL2 Gene

Additional gene information for RASAL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASAL2 Gene

Genomics for RASAL2 Gene

Regulatory Elements for RASAL2 Gene

Enhancers for RASAL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H178055 1.2 Ensembl ENCODE 20.8 -36.7 -36676 4.1 HDGF FOXA2 ARID4B DMAP1 YY1 ATF7 DEK TSHZ1 MIER2 REST RASAL2 RASAL2-AS1 SEC16B LOC730102 ENSG00000254154
GH01H178124 1.3 Ensembl ENCODE dbSUPER 18.4 +33.3 33327 4.5 FOXA2 ARID4B SIN3A BATF RARA RFX5 RCOR1 ATF7 FOS MIXL1 RASAL2-AS1 RASAL2 LOC105371630 GC01M178037
GH01H178051 1.2 Ensembl ENCODE 11.8 -41.1 -41088 3 FOXA2 ATF1 ZFP64 ARID4B DMAP1 YY1 SP5 MXD4 PPARG KAT8 RASAL2-AS1 RASAL2 ENSG00000254154 LOC730102
GH01H178236 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.2 +145.9 145905 6.6 PKNOX1 FOXA2 INSM2 SIN3A RAD21 RFX5 ZNF366 ZSCAN5C RCOR1 FOS RASAL2-AS1 RASAL2 ENSG00000270575 LOC105371629
GH01H178155 0.7 ENCODE dbSUPER 16.4 +62.7 62681 2.6 ZNF362 ZNF384 SP7 RASAL2-AS1 RASAL2 GC01M178037 LOC105371630
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASAL2 on UCSC Golden Path with GeneCards custom track

Promoters for RASAL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000016283 871 3201 PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 ZNF207 DEK SP3

Genomic Locations for RASAL2 Gene

Genomic Locations for RASAL2 Gene
390,419 bases
Plus strand

Genomic View for RASAL2 Gene

Genes around RASAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASAL2 Gene

Proteins for RASAL2 Gene

  • Protein details for RASAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras GTPase-activating protein nGAP
    Protein Accession:
    Secondary Accessions:
    • F8W755
    • O95174
    • Q2TB22
    • Q5TFU9

    Protein attributes for RASAL2 Gene

    1139 amino acids
    Molecular mass:
    128558 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI10612.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASAL2 Gene


neXtProt entry for RASAL2 Gene

Post-translational modifications for RASAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASAL2 Gene

Domains & Families for RASAL2 Gene

Gene Families for RASAL2 Gene

Suggested Antigen Peptide Sequences for RASAL2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RASAL2: view

No data available for UniProtKB/Swiss-Prot for RASAL2 Gene

Function for RASAL2 Gene

Molecular function for RASAL2 Gene

UniProtKB/Swiss-Prot Function:
Inhibitory regulator of the Ras-cyclic AMP pathway.

Phenotypes From GWAS Catalog for RASAL2 Gene

Gene Ontology (GO) - Molecular Function for RASAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA,TAS --
GO:0005515 protein binding IPI 15324660
genes like me logo Genes that share ontologies with RASAL2: view
genes like me logo Genes that share phenotypes with RASAL2: view

Animal Models for RASAL2 Gene

MGI Knock Outs for RASAL2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASAL2 Gene

Localization for RASAL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASAL2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA --
genes like me logo Genes that share ontologies with RASAL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASAL2 Gene

Pathways & Interactions for RASAL2 Gene

SuperPathways for RASAL2 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 HIV Life Cycle
5 Innate Immune System
genes like me logo Genes that share pathways with RASAL2: view

Pathways by source for RASAL2 Gene

1 Cell Signaling Technology pathway for RASAL2 Gene
1 KEGG pathway for RASAL2 Gene

Gene Ontology (GO) - Biological Process for RASAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction IEA,TAS 9877179
GO:0043087 regulation of GTPase activity IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0046580 negative regulation of Ras protein signal transduction IBA --
genes like me logo Genes that share ontologies with RASAL2: view

No data available for SIGNOR curated interactions for RASAL2 Gene

Drugs & Compounds for RASAL2 Gene

No Compound Related Data Available

Transcripts for RASAL2 Gene

mRNA/cDNA for RASAL2 Gene

Unigene Clusters for RASAL2 Gene

RAS protein activator like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASAL2 Gene

No ASD Table

Relevant External Links for RASAL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RASAL2 Gene

This gene is overexpressed in Synovial fluid (13.9), Milk (11.6), and Uterus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RASAL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASAL2 Gene:


SOURCE GeneReport for Unigene cluster for RASAL2 Gene:


Evidence on tissue expression from TISSUES for RASAL2 Gene

  • Heart(4.2)
  • Liver(4.1)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with RASAL2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASAL2 Gene

Orthologs for RASAL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASAL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RASAL2 33 34
  • 99.58 (n)
(Canis familiaris)
Mammalia RASAL2 33 34
  • 94.17 (n)
(Monodelphis domestica)
Mammalia RASAL2 34
  • 94 (a)
(Mus musculus)
Mammalia Rasal2 33 16 34
  • 92.78 (n)
(Bos Taurus)
Mammalia RASAL2 33 34
  • 92.33 (n)
(Ornithorhynchus anatinus)
Mammalia RASAL2 34
  • 86 (a)
(Gallus gallus)
Aves RASAL2 33 34
  • 81.56 (n)
(Anolis carolinensis)
Reptilia RASAL2 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasal2 33
  • 76.45 (n)
Str.11362 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1575 33
(Danio rerio)
Actinopterygii rasal2 33 34
  • 70.89 (n)
Dr.24417 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7799 33
fruit fly
(Drosophila melanogaster)
Insecta CG42684 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea gap-2 35 34
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD2 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6146 34
  • 35 (a)
Species where no ortholog for RASAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASAL2 Gene

Gene Tree for RASAL2 (if available)
Gene Tree for RASAL2 (if available)

Paralogs for RASAL2 Gene

Paralogs for RASAL2 Gene

(4) SIMAP similar genes for RASAL2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RASAL2: view

Variants for RASAL2 Gene

Sequence variations from dbSNP and Humsavar for RASAL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs765646105 A colorectal cancer sample 178,442,684(+) ATTGC(A/T)GGCGA reference, missense
VAR_035542 A breast cancer sample
rs193921085 Uncertain significance 178,473,216(+) ATGGT(G/T)AATTC reference, stop-gained, stop-lost
rs1000002711 -- 178,295,917(+) TTAGC(A/G)TAATC intron-variant
rs1000019746 -- 178,095,798(+) TTCTT(C/G)TCTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RASAL2 Gene

Variant ID Type Subtype PubMed ID
nsv946518 CNV duplication 23825009
nsv548252 CNV gain 21841781
nsv508670 CNV deletion 20534489
nsv473443 CNV novel sequence insertion 20440878
nsv1142076 CNV tandem duplication 24896259
esv3588033 CNV loss 21293372
esv3588032 CNV loss 21293372
esv3588031 CNV loss 21293372
esv3588030 CNV loss 21293372
esv3588029 CNV loss 21293372
esv3416886 CNV duplication 20981092
esv2606666 CNV deletion 19546169
esv2534493 CNV deletion 19546169

Variation tolerance for RASAL2 Gene

Residual Variation Intolerance Score: 5.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASAL2 Gene

Disorders for RASAL2 Gene

Relevant External Links for RASAL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RASAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASAL2 Gene

Publications for RASAL2 Gene

  1. A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25. (PMID: 9877179) Noto S … Hatakeyama M (FEBS letters 1998) 2 3 4 60
  2. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B … Franks PW (Diabetologia 2010) 3 45 60
  3. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) Melén E … Lasky-Su J (The Journal of allergy and clinical immunology 2010) 3 45 60
  4. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (PMID: 19079260) Thorleifsson G … Stefansson K (Nature genetics 2009) 3 45 60
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60

Products for RASAL2 Gene

Sources for RASAL2 Gene

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