Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RASAL2 Gene

Aliases for RASAL2 Gene

  • RAS Protein Activator Like 2 2 3 5
  • RAS Protein Activator-Like 2 3 4
  • NGAP 3 4
  • Ras GTPase Activating Protein-Like 2
  • RAS Protein Activator Like 1 3
  • Ras Protein Activator Like 1 2

External Ids for RASAL2 Gene

Previous GeneCards Identifiers for RASAL2 Gene

  • GC01P175834
  • GC01P173491
  • GC01P174643
  • GC01P175303
  • GC01P174795
  • GC01P176329
  • GC01P149291

Summaries for RASAL2 Gene

Entrez Gene Summary for RASAL2 Gene

  • This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASAL2 Gene

RASAL2 (RAS Protein Activator Like 2) is a Protein Coding gene. Diseases associated with RASAL2 include Prostate Cancer Susceptibility. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by PTK6. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RASAL1.

UniProtKB/Swiss-Prot for RASAL2 Gene

  • Inhibitory regulator of the Ras-cyclic AMP pathway.

Gene Wiki entry for RASAL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASAL2 Gene

Genomics for RASAL2 Gene

Regulatory Elements for RASAL2 Gene

Enhancers for RASAL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RASAL2 on UCSC Golden Path with GeneCards custom track

Promoters for RASAL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASAL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASAL2 Gene

178,093,729 bp from pter
178,484,147 bp from pter
390,419 bases
Plus strand

Genomic View for RASAL2 Gene

Genes around RASAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASAL2 Gene

Proteins for RASAL2 Gene

  • Protein details for RASAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras GTPase-activating protein nGAP
    Protein Accession:
    Secondary Accessions:
    • F8W755
    • O95174
    • Q2TB22
    • Q5TFU9

    Protein attributes for RASAL2 Gene

    1139 amino acids
    Molecular mass:
    128558 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI10612.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASAL2 Gene


neXtProt entry for RASAL2 Gene

Proteomics data for RASAL2 Gene at MOPED

Post-translational modifications for RASAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASAL2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RASAL2 (RASAL2)

No data available for DME Specific Peptides for RASAL2 Gene

Domains & Families for RASAL2 Gene

Suggested Antigen Peptide Sequences for RASAL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
  • Contains 1 PH domain.
  • Contains 1 Ras-GAP domain.
genes like me logo Genes that share domains with RASAL2: view

Function for RASAL2 Gene

Molecular function for RASAL2 Gene

UniProtKB/Swiss-Prot Function:
Inhibitory regulator of the Ras-cyclic AMP pathway.

Gene Ontology (GO) - Molecular Function for RASAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with RASAL2: view
genes like me logo Genes that share phenotypes with RASAL2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASAL2 Gene

Localization for RASAL2 Gene

Subcellular locations from

Jensen Localization Image for RASAL2 Gene COMPARTMENTS Subcellular localization image for RASAL2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RASAL2 Gene

Pathways & Interactions for RASAL2 Gene

SuperPathways for RASAL2 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Developmental Biology
3 Immune System
4 Signaling by PTK6
5 Signaling by GPCR
genes like me logo Genes that share pathways with RASAL2: view

Pathways by source for RASAL2 Gene

1 Cell Signaling Technology pathway for RASAL2 Gene
1 BioSystems pathway for RASAL2 Gene

Gene Ontology (GO) - Biological Process for RASAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0007165 signal transduction IEA,TAS 9877179
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RASAL2: view

No data available for SIGNOR curated interactions for RASAL2 Gene

Drugs & Compounds for RASAL2 Gene

No Compound Related Data Available

Transcripts for RASAL2 Gene

mRNA/cDNA for RASAL2 Gene

(7) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASAL2 Gene

RAS protein activator like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASAL2 Gene

No ASD Table

Relevant External Links for RASAL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASAL2 Gene

mRNA expression in normal human tissues for RASAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RASAL2 Gene

This gene is overexpressed in Synovial fluid (13.9), Milk (11.6), and Uterus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASAL2 Gene

SOURCE GeneReport for Unigene cluster for RASAL2 Gene Hs.496139

genes like me logo Genes that share expression patterns with RASAL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RASAL2 Gene

Orthologs for RASAL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASAL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASAL2 35
  • 92.33 (n)
  • 97.77 (a)
  • 97 (a)
(Canis familiaris)
Mammalia RASAL2 35
  • 94.17 (n)
  • 98.52 (a)
  • 98 (a)
(Mus musculus)
Mammalia Rasal2 35
  • 92.78 (n)
  • 97.11 (a)
Rasal2 16
Rasal2 36
  • 97 (a)
(Pan troglodytes)
Mammalia RASAL2 35
  • 99.58 (n)
  • 99.77 (a)
  • 99 (a)
(Monodelphis domestica)
Mammalia RASAL2 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia RASAL2 36
  • 86 (a)
(Gallus gallus)
Aves RASAL2 35
  • 81.56 (n)
  • 91.47 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia RASAL2 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasal2 35
  • 76.45 (n)
  • 86.44 (a)
Str.11362 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1575 35
(Danio rerio)
Actinopterygii Dr.24417 35
rasal2 35
  • 70.89 (n)
  • 77.17 (a)
rasal2 36
  • 70 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7799 35
fruit fly
(Drosophila melanogaster)
Insecta CG42684 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea gap-2 37
  • 44 (a)
gap-2 36
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD2 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6146 36
  • 35 (a)
Species with no ortholog for RASAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASAL2 Gene

Gene Tree for RASAL2 (if available)
Gene Tree for RASAL2 (if available)

Paralogs for RASAL2 Gene

Paralogs for RASAL2 Gene

(4) SIMAP similar genes for RASAL2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RASAL2: view

Variants for RASAL2 Gene

Sequence variations from dbSNP and Humsavar for RASAL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035541 A colorectal cancer sample
VAR_035542 A breast cancer sample
rs170288 -- 178,153,486(+) CCAGA(C/T)GTAGA intron-variant
rs172726 -- 178,112,876(+) gcaca(A/T)tgtgc intron-variant
rs178397 -- 178,212,419(+) GCTAA(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASAL2 Gene

Variant ID Type Subtype PubMed ID
nsv508670 CNV Loss 20534489
nsv872568 CNV Loss 21882294
esv2534493 CNV Deletion 19546169
esv2606666 CNV Deletion 19546169
esv268437 CNV Insertion 20981092
esv273543 CNV Insertion 20981092

Variation tolerance for RASAL2 Gene

Residual Variation Intolerance Score: 5.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RASAL2 Gene

Disorders for RASAL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASAL2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostate cancer susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RASAL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RASAL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASAL2 Gene

Publications for RASAL2 Gene

  1. A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25. (PMID: 9877179) Noto S. … Hatakeyama M. (FEBS Lett. 1998) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets. (PMID: 24763612) Stefanska B. … Szyf M. (Clin. Cancer Res. 2014) 3
  5. RASAL2 down-regulation in ovarian cancer promotes epithelial-mesenchymal transition and metastasis. (PMID: 25216515) Huang Y. … Yao Z. (Oncotarget 2014) 3

Products for RASAL2 Gene

Sources for RASAL2 Gene