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Aliases for RASAL2 Gene

Aliases for RASAL2 Gene

  • RAS Protein Activator Like 2 2 3
  • NGAP 3 4 6
  • Ras Protein Activator Like 1 2 3
  • RAS Protein Activator-Like 2 3 4
  • Ras GTPase Activating Protein-Like 2
  • Ras GTPase-Activating Protein NGAP 3

External Ids for RASAL2 Gene

Previous GeneCards Identifiers for RASAL2 Gene

  • GC01P175834
  • GC01P173491
  • GC01P174643
  • GC01P175303
  • GC01P174795
  • GC01P176329
  • GC01P149291

Summaries for RASAL2 Gene

Entrez Gene Summary for RASAL2 Gene

  • This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASAL2 Gene

RASAL2 (RAS Protein Activator Like 2) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is RASA2.

UniProtKB/Swiss-Prot for RASAL2 Gene

  • Inhibitory regulator of the Ras-cyclic AMP pathway

Gene Wiki entry for RASAL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASAL2 Gene

Genomics for RASAL2 Gene

Regulatory Elements for RASAL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASAL2 Gene

Start:
178,093,729 bp from pter
End:
178,484,147 bp from pter
Size:
390,419 bases
Orientation:
Plus strand

Genomic View for RASAL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASAL2 Gene

Proteins for RASAL2 Gene

  • Protein details for RASAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJF2-NGAP_HUMAN
    Recommended name:
    Ras GTPase-activating protein nGAP
    Protein Accession:
    Q9UJF2
    Secondary Accessions:
    • F8W755
    • O95174
    • Q2TB22
    • Q5TFU9

    Protein attributes for RASAL2 Gene

    Size:
    1139 amino acids
    Molecular mass:
    128558 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI10612.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASAL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASAL2 Gene

Proteomics data for RASAL2 Gene at MOPED

Post-translational modifications for RASAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASAL2 Gene

No data available for DME Specific Peptides for RASAL2 Gene

Domains for RASAL2 Gene

Gene Families for RASAL2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for RASAL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJF2

UniProtKB/Swiss-Prot:

NGAP_HUMAN :
  • Q9UJF2
Domain:
  • Contains 1 C2 domain.
  • Contains 1 PH domain.
  • Contains 1 Ras-GAP domain.
genes like me logo Genes that share domains with RASAL2: view

Function for RASAL2 Gene

Molecular function for RASAL2 Gene

UniProtKB/Swiss-Prot Function:
Inhibitory regulator of the Ras-cyclic AMP pathway

Gene Ontology (GO) - Molecular Function for RASAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 18985028
genes like me logo Genes that share ontologies with RASAL2: view

Phenotypes for RASAL2 Gene

MGI mutant phenotypes for RASAL2:
inferred from 1 alleles
GenomeRNAi human phenotypes for RASAL2:
genes like me logo Genes that share phenotypes with RASAL2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASAL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RASAL2 Gene

Localization for RASAL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASAL2 Gene COMPARTMENTS Subcellular localization image for RASAL2 gene
Compartment Confidence
cytosol 3
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for RASAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA --
genes like me logo Genes that share ontologies with RASAL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASAL2 Gene

Pathways for RASAL2 Gene

genes like me logo Genes that share pathways with RASAL2: view

Pathways by source for RASAL2 Gene

1 BioSystems pathway for RASAL2 Gene
1 KEGG pathway for RASAL2 Gene

Gene Ontology (GO) - Biological Process for RASAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0042325 regulation of phosphorylation --
GO:0043547 positive regulation of GTPase activity TAS 9877179
GO:0046580 negative regulation of Ras protein signal transduction IBA --
genes like me logo Genes that share ontologies with RASAL2: view

Transcripts for RASAL2 Gene

mRNA/cDNA for RASAL2 Gene

(1) Selected AceView cDNA sequences:
(7) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASAL2 Gene

RAS protein activator like 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASAL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASAL2 Gene

No ASD Table

Relevant External Links for RASAL2 Gene

GeneLoc Exon Structure for
RASAL2
ECgene alternative splicing isoforms for
RASAL2

Expression for RASAL2 Gene

mRNA expression in normal human tissues for RASAL2 Gene

Protein differential expression in normal tissues for RASAL2 Gene

This gene is overexpressed in Synovial fluid (13.9), Milk (11.6), and Uterus (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASAL2 Gene

SOURCE GeneReport for Unigene cluster for RASAL2 Gene Hs.496139

genes like me logo Genes that share expressions with RASAL2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for RASAL2 Gene

Orthologs for RASAL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASAL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASAL2 35
  • 92.33 (n)
  • 97.77 (a)
RASAL2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASAL2 35
  • 94.17 (n)
  • 98.52 (a)
RASAL2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasal2 35
  • 92.78 (n)
  • 97.11 (a)
Rasal2 16
Rasal2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RASAL2 35
  • 99.58 (n)
  • 99.77 (a)
RASAL2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASAL2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASAL2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASAL2 35
  • 81.56 (n)
  • 91.47 (a)
RASAL2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASAL2 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasal2 35
  • 76.45 (n)
  • 86.44 (a)
Str.11362 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1575 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24417 35
rasal2 35
  • 70.89 (n)
  • 77.17 (a)
rasal2 36
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7799 35
fruit fly
(Drosophila melanogaster)
Insecta CG42684 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gap-2 37
  • 44 (a)
gap-2 36
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD2 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6146 36
  • 35 (a)
OneToMany
Species with no ortholog for RASAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASAL2 Gene

ENSEMBL:
Gene Tree for RASAL2 (if available)
TreeFam:
Gene Tree for RASAL2 (if available)

Paralogs for RASAL2 Gene

Paralogs for RASAL2 Gene

Selected SIMAP similar genes for RASAL2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RASAL2: view

Variants for RASAL2 Gene

Sequence variations from dbSNP and Humsavar for RASAL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs170288 -- 178,153,486(+) CCAGA(C/T)GTAGA intron-variant
rs172726 -- 178,112,876(+) gcaca(A/T)tgtgc intron-variant
rs178397 -- 178,212,419(+) GCTAA(C/T)GGAGG intron-variant
rs186416 -- 178,112,822(+) agtta(A/G)tgggt intron-variant
rs192885 -- 178,112,810(+) tgcta(A/G)atgac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASAL2 Gene

Variant ID Type Subtype PubMed ID
nsv508670 CNV Loss 20534489
nsv872568 CNV Loss 21882294
esv2534493 CNV Deletion 19546169
esv2606666 CNV Deletion 19546169
esv268437 CNV Insertion 20981092
esv273543 CNV Insertion 20981092

Relevant External Links for RASAL2 Gene

HapMap Linkage Disequilibrium report
RASAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASAL2 Gene

Disorders for RASAL2 Gene

Relevant External Links for RASAL2

Genetic Association Database (GAD)
RASAL2
Human Genome Epidemiology (HuGE) Navigator
RASAL2

No disorders were found for RASAL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RASAL2 Gene

Publications for RASAL2 Gene

  1. A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25. (PMID: 9877179) Noto S. … Hatakeyama M. (FEBS Lett. 1998) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (PMID: 19079260) Thorleifsson G. … Stefansson K. (Nat. Genet. 2009) 3 48
  4. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 48
  5. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) MelAcn E. … Lasky-Su J. (J. Allergy Clin. Immunol. 2010) 3 48

Products for RASAL2 Gene

Sources for RASAL2 Gene

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