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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASAL1 Gene

protein-coding   GIFtS: 53
GCID: GC12M113537

RAS Protein Activator Like 1 (GAP1 Like)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAS Protein Activator Like 1 (GAP1 Like)1 2
RASAL2 3 5
GAP1 Like Protein2
RasGAP-Activating-Like Protein 12

External Ids:    HGNC: 98731   Entrez Gene: 84372   Ensembl: ENSG000001113447   OMIM: 6041185   UniProtKB: O952943   

Export aliases for RASAL1 gene to outside databases

Previous GC identifers: GC12M112432 GC12M113056 GC12M113319 GC12M111949 GC12M112000 GC12M112021 GC12M110549


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RASAL1 Gene:
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins
stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS
function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive
GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular
family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast
to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues.
Alternatively spliced transcript variants that encode different isoforms have been described (provided by RefSeq,
Jul 2010)

GeneCards Summary for RASAL1 Gene: 
RASAL1 (RAS protein activator like 1 (GAP1 like)) is a protein-coding gene. Diseases associated with RASAL1 include gastric cancer, and thyroiditis. GO annotations related to this gene include phospholipid binding and Ras GTPase activator activity. An important paralog of this gene is SYNGAP1.

UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294
Function: Probable inhibitory regulator of the Ras-cyclic AMP pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASAL1 gene promoter:
         NF-1   NF-1/L   Lmo2   AP-2gamma   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RASAL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RASAL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23-q24   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q23-q24

RASAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASAL1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M113537:  view genomic region     (about GC identifiers)

Start:
113,536,624 bp from pter      End:
113,574,044 bp from pter
Size:
37,421 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294 (See protein sequence)
Recommended Name: RasGAP-activating-like protein 1  
Size: 804 amino acids; 90016 Da
Sequence caution: Sequence=BAD92172.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7ZKM4 C9JFK5 F8VQX1 Q52M03 Q59H24 Q96CC7
Alternative splicing: 4 isoforms:  O95294-1   O95294-2   O95294-3   O95294-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RASAL1: NX_O95294

Explore proteomics data for RASAL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95294

  • RASAL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RASAL1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001180449.1  NP_001180450.1  NP_004649.2  

    ENSEMBL proteins: 
     ENSP00000450244   ENSP00000261729   ENSP00000395920   ENSP00000448510  

    Human Recombinant Protein Products for RASAL1: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for RASAL1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IBA--
    GO:0031235intrinsic to internal side of plasma membrane IBA--

    RASAL1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    5/9 InterPro protein domains (see all 9):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR018029 C2_membr_targeting
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry O95294

    ProtoNet protein and cluster: O95294

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain


    RASAL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASL1_HUMAN, O95294
    Function: Probable inhibitory regulator of the Ras-cyclic AMP pathway

         Genatlas biochemistry entry for RASAL1:
    RAS GTPase-activating-like 1,highly expressed in the follicular cells of the thyroid and adrenal medulla

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0005099Ras GTPase activator activity IBA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0046872metal ion binding IEA--
         
    RASAL1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RASAL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RASAL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASAL1 
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    hsa-miR-100* hsa-miR-148b hsa-miR-301a hsa-miR-1299 hsa-miR-130b hsa-miR-3713 hsa-miR-148a hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidRASAL1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASAL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RASAL1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for RASAL1 (O952943 ENSP000002617294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAPGEF2Q9Y4G83I2D: score=2 
    APLP1P516933I2D: score=1 
    APLP2Q064813I2D: score=1 
    HRASENSP000003098454STRING: ENSP00000309845
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9751798
    GO:0032320positive regulation of Ras GTPase activity IBA--
    GO:0035556intracellular signal transduction IEA--
    GO:0046580negative regulation of Ras protein signal transduction IBA--
    GO:0051056regulation of small GTPase mediated signal transduction ----

    RASAL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RASAL1 (RASL1)

    Search CenterWatch for drugs/clinical trials and news about RASAL1 / RASL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RASAL1 gene (3 alternative transcripts): 
    NM_001193520.1  NM_001193521.1  NM_004658.2  

    Unigene Cluster for RASAL1:

    RAS protein activator like 1 (GAP1 like)
    Hs.528693  [show with all ESTs]
    Unigene Representative Sequence: NM_004658
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546530(uc010syp.2 uc001tul.3 uc001tun.2 uc001tum.2)
    ENST00000261729 ENST00000446861(uc001tuo.4) ENST00000549444 ENST00000548055
    ENST00000551051 ENST00000546727 ENST00000418411(uc010syq.2) ENST00000548972(uc010syr.2)
    ENST00000547810
    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RASAL1 (see all 19):
    hsa-miR-100* hsa-miR-148b hsa-miR-301a hsa-miR-1299 hsa-miR-130b hsa-miR-3713 hsa-miR-148a hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidRASAL1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASAL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASAL1
    Sirion Biotech Customized lentivirus for stable overexpression of RASAL1 
                         Customized lentivirus expression plasmids for stable overexpression of RASAL1 
    Primer
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    OriGene qPCR primer pairs and template standards for RASAL1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASAL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASAL1

    Additional mRNA sequence: 

    AB208935.1 AF086713.1 AK294350.1 AK309562.1 AL136672.1 BC014420.1 BC093724.1 BC143258.1 
    BC143261.1 BC143262.1 BX640867.1 BX640986.1 

    6 DOTS entries:

    DT.95268941  DT.75100204  DT.100777155  DT.92422235  DT.97840247  DT.40191795 

    24/57 AceView cDNA sequences (see all 57):

    BM714372 AF086713 NM_004658 BC014420 BX093862 AL560821 BF764942 CA502874 
    AV708281 BG491055 BX640867 AL582279 BE396546 BF976322 BM675175 BX640986 
    BU600136 AW248252 BX349376 BX392043 BX421246 BE562264 CK430755 CF136072 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RASAL1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
    SP1:        -     -     -                       -                                                                                                     -         
    SP2:                                            -                                                                                         -           -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -     -     -     -     -     -     -     -                                                                                 

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
    SP1:  -                                 
    SP2:  -                                 
    SP3:  -                                 
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RASAL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASAL1 expression in normal human tissues (normalized intensities)      RASAL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGTTGTT
    RASAL1 Expression
    About this image


    RASAL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Lymph (Hematopoietic System)
             LYMPH NODE   
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Esophagus
             esophageal epithelium   

    See RASAL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASAL1

    SOURCE GeneReport for Unigene cluster: Hs.528693

    UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294
    Tissue specificity: Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and
    trachea

        SABiosciences Custom PCR Arrays for RASAL1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASAL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASAL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RASAL1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasal11 , 5 RAS protein activator like 1 (GAP1 like)1, 5 84.81(n)1
    86.74(a)1
      5 (60.63 cM)5
    194151  NM_013832.31  NP_038860.21 
     1206488125 
    chicken
    (Gallus gallus)
    Aves RASAL11 RAS protein activator like 1 (GAP1 like) 70.52(n)
    64.31(a)
      771057  XM_001234362.2  XP_001234363.2 
    lizard
    (Anolis carolinensis)
    Reptilia RASAL16
    RAS protein activator like 1 (GAP1 like)
    63(a)
    1 ↔ 1
    GL343338.1(753895-780181)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ050949.12   -- 78.91(n)    BJ050949.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CU694486.16
    RASAL1 (1 of 2)6
    RAS protein activator like 1 (GAP1 like)
    62(a)
    59(a)
    1 ↔ many
    1 ↔ many
    8(1834093-1865089)
    Zv9_NA771(71375-99986)
    worm
    (Caenorhabditis elegans)
    Secernentea gap-16
    Ras GTPase-activating protein gap-1
    23(a)
    1 → many
    X(2192504-2195348)


    ENSEMBL Gene Tree for RASAL1 (if available)
    TreeFam Gene Tree for RASAL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASAL1 gene
    SYNGAP12  DAB2IP2  RASA42  RASA12  RASAL32  RASA22  RASA4B2  RASAL22  
    RASA32  
    3 SIMAP similar genes for RASAL1 using alignment to 1 protein entry:     RASL1_HUMAN:
    RASA4    RASA4B    RASA3

    RASAL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/951 SNPs in RASAL1 are shown (see all 951)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492836171,2
    Cuntested1113537799(+) GGCACA/GATCCA 6 R C mis10--------
    rs16740971,2
    C,F,A--113536593(+) GGAGGT/CTCATT 3 -- ds500112Minor allele frequency- C:0.26NA WA CSA EA 376
    rs1512859671,2
    C--113536672(+) ATTAGA/CCAGGC 3 -- ut310--------
    rs1142082801,2
    C,F--113536699(+) GTAGTC/TGCAGC 3 -- ut311Minor allele frequency- T:0.01WA 118
    rs1402719391,2
    C--113536720(+) GCTAAC/TGTGGG 3 -- ut310--------
    rs124223051,2
    C,F,A,H--113536759(+) GTGCAC/TTGACC 3 -- ut31 ese34Minor allele frequency- T:0.15NA 128
    rs1454884081,2
    --113536795(+) CTGGGA/CAACAG 3 -- ut310--------
    rs124239061,2
    C,F,H--113536834(+) TAAAAT/GAAAAT 3 -- ut312Minor allele frequency- G:0.16NA 124
    rs789314431,2
    C,F--113536863(+) GTGGTC/TCTCAA 3 -- ut311Minor allele frequency- T:0.01NA 120
    rs1813160251,2
    --113536894(+) ACCTAC/TGGAAT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for RASAL1 (113536624 - 113574044 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RASAL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899527CNV Loss21882294
    dgv1493n71CNV Loss21882294
    nsv899528CNV Loss21882294
    nsv899525CNV Loss21882294
    nsv899530CNV Gain21882294
    nsv519540CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604118    OMIM disorders: --

    2 diseases for RASAL1:    About MalaCards
    gastric cancer    thyroiditis


    RASAL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RASAL1

    Export disorders for RASAL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASAL1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with RASAL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog. (PubMed id 9751798)1, 2, 3, 9 Allen M.... Buckler A. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. (PubMed id 18992247)1, 9 Ohta M....Omata M. (2009)
    5. A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. (PubMed id 15960973)1, 9 Kolfschoten I.G....Agami R. (2005)
    6. Ras GTPase activating (RasGAP) activity of the dual sp ecificity GAP protein Rasal requires colocalization and C2 domain binding to lip id membranes. (PubMed id 23251034)1 Sot B....Wittinghofer A. (2013)
    7. Hypermethylations of RASAL1 and KLOTHO is associated w ith renal dysfunction in a Chinese population environmentally exposed to cadmium . (PubMed id 23665422)1 Zhang C....Wu Q. (2013)
    8. Enforced expression of RASAL1 suppresses cell prolifer ation and the transformation ability of gastric cancer cells. (PubMed id 22825043)1 Qiao F....Fan H. (2012)
    9. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8437 HGNC: 9873 AceView: RASAL1 Ensembl:ENSG00000111344 euGenes: HUgn8437
    ECgene: RASAL1 H-InvDB: RASAL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASAL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASAL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RASAL1 gene:
    Search GeneIP for patents involving RASAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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