Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RASAL1 Gene

protein-coding   GIFtS: 56
GCID: GC12M113537

RAS Protein Activator Like 1 (GAP1 Like)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RAS Protein Activator Like 1 (GAP1 Like)1 2
RASAL2 3 5
GAP1 Like Protein2
RasGAP-Activating-Like Protein 12

External Ids:    HGNC: 98731   Entrez Gene: 84372   Ensembl: ENSG000001113447   OMIM: 6041185   UniProtKB: O952943   

Export aliases for RASAL1 gene to outside databases

Previous GC identifers: GC12M112432 GC12M113056 GC12M113319 GC12M111949 GC12M112000 GC12M112021 GC12M110549


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RASAL1 Gene:
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins
stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS
function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive
GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular
family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast
to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues.
Alternatively spliced transcript variants that encode different isoforms have been described (provided by RefSeq,
Jul 2010)

GeneCards Summary for RASAL1 Gene:
RASAL1 (RAS protein activator like 1 (GAP1 like)) is a protein-coding gene. Diseases associated with RASAL1 include type 1 diabetes, and thyroiditis. GO annotations related to this gene include phospholipid binding and Ras GTPase activator activity. An important paralog of this gene is SYNGAP1.

UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294
Function: Probable inhibitory regulator of the Ras-cyclic AMP pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASAL1 gene promoter:
         NF-1   NF-1/L   Lmo2   AP-2gamma   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RASAL1 promoter sequence
   Search Chromatin IP Primers for RASAL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23-q24   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q23-q24

RASAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASAL1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M113537:  view genomic region     (about GC identifiers)

Start:
113,536,624 bp from pter      End:
113,574,044 bp from pter
Size:
37,421 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294 (See protein sequence)
Recommended Name: RasGAP-activating-like protein 1  
Size: 804 amino acids; 90016 Da
Sequence caution: Sequence=BAD92172.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7ZKM4 C9JFK5 F8VQX1 Q52M03 Q59H24 Q96CC7
Alternative splicing: 4 isoforms:  O95294-1   O95294-2   O95294-3   O95294-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RASAL1: NX_O95294

Explore proteomics data for RASAL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASAL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180449.1  NP_001180450.1  NP_004649.2  

    ENSEMBL proteins: 
     ENSP00000450244   ENSP00000261729   ENSP00000395920   ENSP00000448510  

    RASAL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RASAL1
    GenScript Custom Purified and Recombinant Proteins Services for RASAL1
    Novus Biologicals RASAL1 Protein
    Novus Biologicals RASAL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RASAL1

    RASAL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RASAL1
    OriGene Custom Antibody Services for RASAL1
    Novus Biologicals RASAL1 Antibodies
    Abcam antibodies for RASAL1
    Cloud-Clone Corp. Antibodies for RASAL1
    ThermoFisher Antibodies for RASAL1
    LSBio Antibodies in human, mouse, rat for RASAL1

    RASAL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RASAL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RASAL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RASAL1
    Cloud-Clone Corp. CLIAs for RASAL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    Selected InterPro protein domains (see all 8):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR023152 RasGAP_CS

    Graphical View of Domain Structure for InterPro Entry O95294

    ProtoNet protein and cluster: O95294

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain


    RASAL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASL1_HUMAN, O95294
    Function: Probable inhibitory regulator of the Ras-cyclic AMP pathway

         Genatlas biochemistry entry for RASAL1:
    RAS GTPase-activating-like 1,highly expressed in the follicular cells of the thyroid and adrenal medulla

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0005099Ras GTPase activator activity IBA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding TAS9751798
    GO:0046872metal ion binding IEA--
         
    RASAL1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASAL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RASAL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASAL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASAL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RASAL1:
    hsa-mir-421 (MIRT039442)

    Block miRNA regulation of human, mouse, rat RASAL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASAL1 (see all 19):
    hsa-miR-100* hsa-miR-148b hsa-miR-301a hsa-miR-1299 hsa-miR-130b hsa-miR-3713 hsa-miR-148a hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidRASAL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RASAL1
    Predesigned siRNA for gene silencing in human, mouse, rat RASAL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RASAL1

    Clone
    Products:
         
    OriGene clones in human, mouse for RASAL1 (see all 13)
    OriGene ORF clones in mouse, rat for RASAL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RASAL1 (NM_001193520)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASAL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASAL1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RASAL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RASAL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASAL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IBA--
    GO:0031235intrinsic component of the cytoplasmic side of the plasma membrane IBA--

    RASAL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RASAL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Ras signaling pathway
    Ras signaling pathway0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for RASAL1):
        Ras signaling pathway


    RASAL1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASAL1
    Interactions:

        GeneGlobe Interaction Network for RASAL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for RASAL1 (O952943 ENSP000002617294) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAPGEF2Q9Y4G83I2D: score=2 
    APLP1P516933I2D: score=1 
    APLP2Q064813I2D: score=1 
    HRASENSP000003098454STRING: ENSP00000309845
    PER1ENSP000003144204STRING: ENSP00000314420
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9751798
    GO:0032320positive regulation of Ras GTPase activity IBA--
    GO:0035556intracellular signal transduction IEA--
    GO:0046580negative regulation of Ras protein signal transduction IBA--
    GO:0051056regulation of small GTPase mediated signal transduction ----

    RASAL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASAL1 (RASL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RASAL1 gene (3 alternative transcripts): 
    NM_001193520.1  NM_001193521.1  NM_004658.2  

    Unigene Cluster for RASAL1:

    RAS protein activator like 1 (GAP1 like)
    Hs.528693  [show with all ESTs]
    Unigene Representative Sequence: NM_004658
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546530(uc010syp.2 uc001tul.3 uc001tun.2 uc001tum.2)
    ENST00000261729 ENST00000446861(uc001tuo.4) ENST00000549444 ENST00000548055
    ENST00000551051 ENST00000546727 ENST00000418411(uc010syq.2) ENST00000548972(uc010syr.2)
    ENST00000547810
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RASAL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASAL1 (see all 19):
    hsa-miR-100* hsa-miR-148b hsa-miR-301a hsa-miR-1299 hsa-miR-130b hsa-miR-3713 hsa-miR-148a hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidRASAL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RASAL1
    Predesigned siRNA for gene silencing in human, mouse, rat RASAL1
    Clone
    Products:
         
    OriGene clones in human, mouse for RASAL1 (see all 13)
    OriGene ORF clones in mouse, rat for RASAL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RASAL1 (NM_001193520)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASAL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASAL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RASAL1
    OriGene qSTAR qPCR primer pairs in human, mouse for RASAL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASAL1
      QuantiTect SYBR Green Assays in human, mouse, rat RASAL1
      QuantiFast Probe-based Assays in human, mouse, rat RASAL1

    Additional mRNA sequence: 

    AB208935.1 AF086713.1 AK294350.1 AK309562.1 AL136672.1 BC014420.1 BC093724.1 BC143258.1 
    BC143261.1 BC143262.1 BX640867.1 BX640986.1 

    6 DOTS entries:

    DT.95268941  DT.75100204  DT.100777155  DT.92422235  DT.97840247  DT.40191795 

    Selected AceView cDNA sequences (see all 57):

    BM714372 BC014420 NM_004658 AF086713 BX093862 AL560821 BF764942 CA502874 
    AV708281 BX640986 BX640867 BM675175 BU600136 BF976322 BE396546 BG696209 
    BI226487 AL582279 AW248252 BX374033 BX349376 AL136672 AI741759 BF974829 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RASAL1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
    SP1:        -     -     -                       -                                                                                                     -         
    SP2:                                            -                                                                                         -           -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -     -     -     -     -     -     -     -                                                                                 

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
    SP1:  -                                 
    SP2:  -                                 
    SP3:  -                                 
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RASAL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RASAL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGTTGTT
    RASAL1 Expression
    About this image


    RASAL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Lymph (Hematopoietic System)
    RASAL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASAL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528693

    UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294
    Tissue specificity: Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and
    trachea

        Custom PCR Arrays for RASAL1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RASAL1
    OriGene qSTAR qPCR primer pairs in human, mouse for RASAL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASAL1
    QuantiTect SYBR Green Assays in human, mouse, rat RASAL1
    QuantiFast Probe-based Assays in human, mouse, rat RASAL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASAL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RASAL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasal11 , 5 RAS protein activator like 1 (GAP1 like)1, 5 84.81(n)1
    86.74(a)1
      5 (60.63 cM)5
    194151  NM_013832.41  NP_038860.21 
     1206488125 
    chicken
    (Gallus gallus)
    Aves RASAL11 RAS protein activator like 1 (GAP1 like) 71.09(n)
    66.35(a)
      771057  XM_001234362.3  XP_001234363.3 
    lizard
    (Anolis carolinensis)
    Reptilia RASAL16
    RAS protein activator like 1 (GAP1 like)
    64(a)
    1 ↔ 1
    GL343338.1(753895-780181)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ050949.12   -- 78.91(n)    BJ050949.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CU694486.16
    RASAL1 (2 of 2)6
    RAS protein activator like 1 (GAP1 like)
    62(a)
    59(a)
    1 ↔ many
    1 ↔ many
    8(1834093-1865089) ENSDARG00000041515
    Zv9_NA771(71375-99986) ENSDARG00000089380
    fruit fly
    (Drosophila melanogaster)
    Insecta Gap16
    GTPase-activating protein 1
    20(a)
    1 → many
    3L(9832193-9848385)
    worm
    (Caenorhabditis elegans)
    Secernentea gap-16
    Protein GAP-1 (gap-1) mRNA, complete cds
    25(a)
    1 → many
    X(2192504-2195348) WBGene00001515


    ENSEMBL Gene Tree for RASAL1 (if available)
    TreeFam Gene Tree for RASAL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RASAL1 gene
    SYNGAP12  DAB2IP2  RASA42  RASA12  RASAL32  RASA22  RASA4B2  RASAL22  
    RASA32  
    3 SIMAP similar genes for RASAL1 using alignment to 1 protein entry:     RASL1_HUMAN:
    RASA4    RASA4B    RASA3

    RASAL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RASAL1 (see all 951)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492836171,2
    Cuntested1113537799(+) GGCACA/GATCCA 6 R C mis10--------
    rs16740971,2
    C,F,A--113536593(+) GGAGGT/CTCATT 3 -- ds500112Minor allele frequency- C:0.26NA WA CSA EA 376
    rs1512859671,2
    C--113536672(+) ATTAGA/CCAGGC 3 -- ut310--------
    rs1142082801,2
    C,F--113536699(+) GTAGTC/TGCAGC 3 -- ut311Minor allele frequency- T:0.01WA 118
    rs1402719391,2
    C--113536720(+) GCTAAC/TGTGGG 3 -- ut310--------
    rs124223051,2
    C,F,A,H--113536759(+) GTGCAC/TTGACC 3 -- ut31 ese34Minor allele frequency- T:0.15NA 128
    rs1454884081,2
    --113536795(+) CTGGGA/CAACAG 3 -- ut310--------
    rs124239061,2
    C,F,H--113536834(+) TAAAAT/GAAAAT 3 -- ut312Minor allele frequency- G:0.16NA 124
    rs789314431,2
    C,F--113536863(+) GTGGTC/TCTCAA 3 -- ut311Minor allele frequency- T:0.01NA 120
    rs1813160251,2
    --113536894(+) ACCTAC/TGGAAT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for RASAL1 (113536624 - 113574044 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RASAL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899527CNV Loss21882294
    dgv1493n71CNV Loss21882294
    nsv899528CNV Loss21882294
    nsv899525CNV Loss21882294
    nsv899530CNV Gain21882294
    nsv519540CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASAL1
    DNA2.0 Custom Variant and Variant Library Synthesis for RASAL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604118    OMIM disorders: --

    4 diseases for RASAL1:    
    About MalaCards
    type 1 diabetes    thyroiditis    esophagitis    cerebritis


    RASAL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RASAL1

    Export disorders for RASAL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RASAL1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with RASAL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog. (PubMed id 9751798)1, 2, 3, 9 Allen M.... Buckler A. (Gene 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    4. Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. (PubMed id 18992247)1, 9 Ohta M....Omata M. (Gastroenterology 2009)
    5. A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. (PubMed id 15960973)1, 9 Kolfschoten I.G....Agami R. (Cell 2005)
    6. Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes. (PubMed id 23251034)1 Sot B....Wittinghofer A. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    7. Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium. (PubMed id 23665422)1 Zhang C....Wu Q. (Toxicol. Appl. Pharmacol. 2013)
    8. Identification of RASAL1 as a major tumor suppressor gene in thyroid cancer. (PubMed id 24136889)1 Liu D....Xing M. (J. Natl. Cancer Inst. 2013)
    9. Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells. (PubMed id 22825043)1 Qiao F....Fan H. (Oncol. Rep. 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8437 HGNC: 9873 AceView: RASAL1 Ensembl:ENSG00000111344 euGenes: HUgn8437
    ECgene: RASAL1 Kegg: 8437 H-InvDB: RASAL1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RASAL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASAL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RASAL1 gene:
    Search GeneIP for patents involving RASAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RASAL1   OriGene RNAi products in human, mouse, rat for RASAL1  
     OriGene qPCR primer pairs and template standards for RASAL1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RASAL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RASAL1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RASAL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RASAL1   OriGene Custom Protein Services for RASAL1  

     
     
     Block miRNA regulation of human, mouse, rat RASAL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RASAL1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASAL1 Predesigned siRNA for gene silencing in human, mouse, rat RASAL1
     QuantiFast Probe-based Assays in human, mouse, rat RASAL1 QuantiTect SYBR Green Assays in human, mouse, rat RASAL1
     Custom PCR Arrays for RASAL1 Search Chromatin IP Primers for RASAL1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASAL1  GeneGlobe Interaction Network for RASAL1
     Regulatory tfbs in RASAL1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RASAL1 GenScript cDNA clones with any tag delivered in your preferred vector for RASAL1
     GenScript Custom Assay Services for RASAL1 GenScript Custom overexpressing Cell Line Services for RASAL1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RASAL1 (RASL1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RASAL1 antibodies
     RASAL1 proteins
     RASAL1 lysates
     Antibodies for RASAL1
     See all of Abcam's Antibodies, Kits and Proteins for RASAL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RASAL1
     Antibodies for RASAL1
     ELISAs for RASAL1
     CLIAs for RASAL1



     Browse ESI BIO Cell Lines and PureStem Progenitors for RASAL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASAL1
     SwitchGear 3'UTR luciferase reporter plasmids for RASAL1
     SwitchGear Promoter luciferase reporter plasmids for RASAL1
     ThermoFisher Antibodies for RASAL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASAL1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASAL1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RASAL1
     LSBio Antibodies in human, mouse, rat for RASAL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RASAL1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4