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Aliases for RASAL1 Gene

Aliases for RASAL1 Gene

  • RAS Protein Activator Like 1 (GAP1 Like) 2 3
  • RASAL 3 4 6
  • RasGAP-Activating-Like Protein 1 3
  • GAP1 Like Protein 3

External Ids for RASAL1 Gene

Previous GeneCards Identifiers for RASAL1 Gene

  • GC12M112432
  • GC12M113319
  • GC12M111949
  • GC12M112000
  • GC12M112021
  • GC12M113537
  • GC12M110549

Summaries for RASAL1 Gene

Entrez Gene Summary for RASAL1 Gene

  • The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

GeneCards Summary for RASAL1 Gene

RASAL1 (RAS Protein Activator Like 1 (GAP1 Like)) is a Protein Coding gene. Among its related pathways are Ras signaling pathway. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is RASA2.

UniProtKB/Swiss-Prot for RASAL1 Gene

  • Probable inhibitory regulator of the Ras-cyclic AMP pathway

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASAL1 Gene

Genomics for RASAL1 Gene

Regulatory Elements for RASAL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASAL1 Gene

113,098,819 bp from pter
113,136,239 bp from pter
37,421 bases
Minus strand

Genomic View for RASAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASAL1 Gene

Proteins for RASAL1 Gene

  • Protein details for RASAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RasGAP-activating-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B7ZKM4
    • C9JFK5
    • F8VQX1
    • Q52M03
    • Q59H24
    • Q96CC7

    Protein attributes for RASAL1 Gene

    804 amino acids
    Molecular mass:
    90016 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD92172.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASAL1 Gene


neXtProt entry for RASAL1 Gene

Proteomics data for RASAL1 Gene at MOPED

Post-translational modifications for RASAL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASAL1 Gene

Antibody Products

No data available for DME Specific Peptides for RASAL1 Gene

Domains for RASAL1 Gene

Suggested Antigen Peptide Sequences for RASAL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Contains 1 Btk-type zinc finger.
  • Contains 2 C2 domains.
  • Contains 1 PH domain.
  • Contains 1 Ras-GAP domain.
  • Contains 1 Btk-type zinc finger.
genes like me logo Genes that share domains with RASAL1: view

Function for RASAL1 Gene

Molecular function for RASAL1 Gene

GENATLAS Biochemistry:
RAS GTPase-activating-like 1,highly expressed in the follicular cells of the thyroid and adrenal medulla
UniProtKB/Swiss-Prot Function:
Probable inhibitory regulator of the Ras-cyclic AMP pathway

Gene Ontology (GO) - Molecular Function for RASAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
GO:0005543 phospholipid binding TAS 9751798
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RASAL1: view

Animal Model Products

miRNA for RASAL1 Gene

miRTarBase miRNAs that target RASAL1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASAL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for RASAL1 Gene

Localization for RASAL1 Gene

Subcellular locations from

Jensen Localization Image for RASAL1 Gene COMPARTMENTS Subcellular localization image for RASAL1 gene
Compartment Confidence
cytosol 3
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RASAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA 16009725
GO:0005886 colocalizes_with plasma membrane IDA 16009725
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA --
genes like me logo Genes that share ontologies with RASAL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASAL1 Gene

Pathways for RASAL1 Gene

SuperPathways for RASAL1 Gene

Superpath Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with RASAL1: view

Pathways by source for RASAL1 Gene

1 KEGG pathway for RASAL1 Gene

Interacting Proteins for RASAL1 Gene

Gene Ontology (GO) - Biological Process for RASAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9751798
GO:0035556 intracellular signal transduction IEA --
GO:0043547 positive regulation of GTPase activity TAS 9751798
GO:0046580 negative regulation of Ras protein signal transduction IBA --
GO:1903861 positive regulation of dendrite extension IDA 23999003
genes like me logo Genes that share ontologies with RASAL1: view

Transcripts for RASAL1 Gene

Unigene Clusters for RASAL1 Gene

RAS protein activator like 1 (GAP1 like):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASAL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASAL1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1: - - - - -
SP2: - - -
SP5: - - - - - - - -

ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
SP1: -
SP2: -
SP3: -

Relevant External Links for RASAL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASAL1 Gene

mRNA expression in normal human tissues for RASAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASAL1 Gene

This gene is overexpressed in Esophagus - Mucosa (5.8).

Protein differential expression in normal tissues for RASAL1 Gene

This gene is overexpressed in Salivary gland (14.9), Brain (14.8), Cervix (11.6), and Stomach (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASAL1 Gene

SOURCE GeneReport for Unigene cluster for RASAL1 Gene Hs.528693

mRNA Expression by UniProt/SwissProt for RASAL1 Gene

Tissue specificity: Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea
genes like me logo Genes that share expressions with RASAL1: view

Primer Products

In Situ Assay Products

No data available for Expression partners for RASAL1 Gene

Orthologs for RASAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASAL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RASAL1 35
  • 88.49 (n)
  • 88.94 (a)
  • 89 (a)
(Canis familiaris)
Mammalia RASAL1 35
  • 88.92 (n)
  • 89.77 (a)
  • 86 (a)
(Mus musculus)
Mammalia Rasal1 35
  • 84.81 (n)
  • 86.74 (a)
Rasal1 16
Rasal1 36
  • 86 (a)
(Pan troglodytes)
Mammalia RASAL1 35
  • 99.48 (n)
  • 99.29 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rasal1 35
  • 84.39 (n)
  • 86.87 (a)
(Monodelphis domestica)
Mammalia RASAL1 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 62 (a)
(Gallus gallus)
Aves RASAL1 35
  • 71.09 (n)
  • 66.35 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia RASAL1 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasal1 35
  • 65.4 (n)
  • 64.64 (a)
(Danio rerio)
Actinopterygii CU694486.1 36
  • 62 (a)
RASAL1 (2 of 2) 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gap1 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea gap-1 36
  • 25 (a)
Species with no ortholog for RASAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASAL1 Gene

Gene Tree for RASAL1 (if available)
Gene Tree for RASAL1 (if available)

Paralogs for RASAL1 Gene

Paralogs for RASAL1 Gene

(3) SIMAP similar genes for RASAL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASAL1: view

Variants for RASAL1 Gene

Sequence variations from dbSNP and Humsavar for RASAL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs118121765 -- 113,124,653(+) GGGGA(A/G)GTCAC intron-variant
rs118061364 -- 113,112,866(+) AGAAT(C/T)GCTTC intron-variant
rs117864705 -- 113,137,814(+) GCCCC(A/C)CACCG upstream-variant-2KB
rs117814532 -- 113,127,612(+) ACCAC(C/T)GCACT intron-variant
rs117716873 -- 113,125,708(+) ATCAA(C/G)TATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASAL1 Gene

Variant ID Type Subtype PubMed ID
nsv519540 CNV Gain+Loss 19592680
nsv899525 CNV Loss 21882294
dgv1493n71 CNV Loss 21882294
nsv899527 CNV Loss 21882294
nsv899528 CNV Loss 21882294
nsv899530 CNV Gain 21882294

Relevant External Links for RASAL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASAL1 Gene

Disorders for RASAL1 Gene

Relevant External Links for RASAL1

Genetic Association Database (GAD)

No disorders were found for RASAL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RASAL1 Gene

Publications for RASAL1 Gene

  1. Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog. (PMID: 9751798) Allen M. … Buckler A. (Gene 1998) 2 3 4 23
  2. A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. (PMID: 15960973) Kolfschoten I.G. … Agami R. (Cell 2005) 3 23
  3. Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. (PMID: 18992247) Ohta M. … Omata M. (Gastroenterology 2009) 3 23
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RASAL1 Gene

Sources for RASAL1 Gene

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