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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASAL1 Gene

protein-coding   GIFtS: 50
GCID: GC12M113537

RAS protein activator like 1 (GAP1 like)
 Explore 2 diseases affiliated with
RASAL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RASAL1    

Aliases
for RASAL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAS Protein Activator Like 1 (GAP1 Like)1 2
RASAL1 2 3 5
GAP1 Like Protein2
RasGAP-Activating-Like Protein 12

External Ids:    HGNC: 98731   Entrez Gene: 84372   Ensembl: ENSG000001113447   OMIM: 6041185   UniProtKB: O952943   

Export aliases for RASAL1 gene to outside databases

Previous GC identifers: GC12M112432 GC12M113056 GC12M113319 GC12M111949 GC12M112000 GC12M112021 GC12M110549


Summaries
for RASAL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RASAL1:
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate
the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the
protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS,
thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains
which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members,
this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants
that encode different isoforms have been described (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294
Function: Probable inhibitory regulator of the Ras-cyclic AMP pathway




Genomic Views
for RASAL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASAL1 gene promoter:
         NF-1   NF-1/L   Lmo2   AP-2gamma   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RASAL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RASAL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23-q24   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q23-q24

RASAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASAL1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M113537:  view genomic region     (about GC identifiers)

Start:
 113,536,624 bp from pter      End:
 113,574,044 bp from pter
Size:
 37,421 bases      Orientation:
 minus strand

Proteins
for RASAL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294 (See protein sequence)
Recommended Name: RasGAP-activating-like protein 1  
Size: 804 amino acids; 90016 Da
Secondary accessions: C9JFK5 Q52M03 Q96CC7
Alternative splicing: 2 isoforms:  O95294-1   O95294-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RASAL1: NX_O95294

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95294

    • RASAL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180449.1  NP_001180450.1  NP_004649.2  

    ENSEMBL proteins: 
     ENSP00000450244   ENSP00000261729   ENSP00000395920   ENSP00000448510  

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    Novus Biologicals RASAL1 Protein
    Novus Biologicals RASAL1 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RASAL1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IBA--
    GO:0031235intrinsic to internal side of plasma membrane IBA--


    RASAL1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RASAL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RASAL1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR018029 C2_membr_targeting
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry O95294

    ProtoNet protein and cluster: O95294

    4 Blocks protein families:
    IPB000008 C2 domain
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain


    Function
    for RASAL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294
    Function: Probable inhibitory regulator of the Ras-cyclic AMP pathway

         Genatlas biochemistry entry for RASAL1:
    RAS GTPase-activating-like 1,highly expressed in the follicular cells of the thyroid and adrenal medulla

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RASAL1 (see all 19):
    hsa-miR-100* hsa-miR-148b hsa-miR-301a hsa-miR-1299 hsa-miR-130b hsa-miR-3713 hsa-miR-148a hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmid: RASAL1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RASAL1 (see all 7)
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for RASAL1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASAL1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0005099Ras GTPase activator activity IBA--
    GO:0005543phospholipid binding IEA--
    GO:0046872metal ion binding IEA--


    RASAL1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for RASAL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RASAL1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for RASAL1 (O952943 ENSP000002617294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAPGEF2Q9Y4G83I2D: score=2 
    APLP1P516933I2D: score=1 
    APLP2Q064813I2D: score=1 
    HRASENSP000003098454STRING: ENSP00000309845
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9751798
    GO:0032320positive regulation of Ras GTPase activity IBA--
    GO:0035556intracellular signal transduction IEA--
    GO:0046580negative regulation of Ras protein signal transduction IBA--
    GO:0051056regulation of small GTPase mediated signal transduction ----


    RASAL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RASAL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RASAL1
    Search CenterWatch for drugs/clinical trials and news about RASAL1 / RASL1 

    Transcripts
    for RASAL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RASAL1 gene (3 alternative transcripts): 
    NM_001193520.1  NM_001193521.1  NM_004658.2  

    Unigene Cluster for RASAL1:

    RAS protein activator like 1 (GAP1 like)
    Hs.528693  [show with all ESTs]
    Unigene Representative Sequence: NM_004658
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546530(uc010syp.2 uc001tul.3 uc001tun.2 uc001tum.2)
    ENST00000261729 ENST00000446861(uc001tuo.4) ENST00000549444 ENST00000548055
    ENST00000551051 ENST00000546727 ENST00000418411(uc010syq.2) ENST00000548972(uc010syr.2)
    ENST00000547810

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASAL1
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RASAL1 (see all 19):
    hsa-miR-100* hsa-miR-148b hsa-miR-301a hsa-miR-1299 hsa-miR-130b hsa-miR-3713 hsa-miR-148a hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmid: RASAL1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RASAL1 (see all 7)
    OriGene shRNA RFP: RASAL1
    OriGene siRNA: RASAL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASAL1
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASAL1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RASAL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASAL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASAL1

    Additional cDNA sequence: 

    AB208935.1 AF086713.1 AK294350.1 AK309562.1 AL136672.1 BC014420.1 BC093724.1 BC143258.1 
    BC143261.1 BC143262.1 BX640867.1 BX640986.1 

    6 DOTS entries:

    DT.95268941  DT.75100204  DT.100777155  DT.92422235  DT.97840247  DT.40191795 

    24/57 AceView cDNA sequences (see all 57):

    CA502874 BM714372 BX093862 AF086713 NM_004658 BC014420 BF764942 AL560821 
    AV708281 BG491055 AW245133 BM853793 AW248252 AL136672 BF974829 BU600136 
    BE396546 BF976322 BX374033 BG696209 BX640867 BX349376 BI226487 AL582279 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RASAL1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
    SP1:        -     -     -                       -                                                                                                     -         
    SP2:                                            -                                                                                         -           -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -     -     -     -     -     -     -     -                                                                                 

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
    SP1:  -                                 
    SP2:  -                                 
    SP3:  -                                 
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RASAL1

    Expression
    for RASAL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASAL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATGTTGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RASAL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RASAL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASAL1

    SOURCE GeneReport for Unigene cluster: Hs.528693

    UniProtKB/Swiss-Prot: RASL1_HUMAN, O95294
    Tissue specificity: Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea

        SABiosciences Custom PCR Arrays for RASAL1
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    In Situ
    Assay Products:     
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    Orthologs
    for RASAL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RASAL1 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RASAL11 RAS protein activator like 1 (GAP1 like) 70.52(n)
    64.31(a)    		   771057  XM_001234362.2  XP_001234363.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RASAL16
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343338.1(754602-779601)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ050949.12   -- 78.91(n)    BJ050949.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01004882.16
    		 --
    		 58(a)
    		 1 ↔ 1
    		 Zv9_NA771(71375-99986)


    ENSEMBL Gene Tree for RASAL1 (if available)
    TreeFam Gene Tree for RASAL1 (if available) 

    Paralogs
    for RASAL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASAL1 gene
    SYNGAP12  DAB2IP2  RASA42  RASA12  RASAL32  RASA22  RASA4B2  RASA32  
    RASAL22  
    4 SIMAP similar genes for RASAL1 using alignment to 4 protein entries:     RASL1_HUMAN (see all proteins):
    RASA4    RASA4B    RASA3    RASA2

    RASAL1 for paralogs           About GeneDecksing



    Genomic Variants
    for RASAL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/773 NCBI SNPs in RASAL1 are shown (see all 773)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1492836171,2
    		C,other113537799(+) GGCACA/GATCCA 6 R C mis10--------
    rs16740971,2
    		C,F,A,--113536593(+) GGAGGT/CTCATT 3 -- ds500112Minor allele frequency- C:0.26NA WA CSA EA 376
    rs1512859671,2
    		--113536672(+) ATTAGA/CCAGGC 3 -- ut310--------
    rs1142082801,2
    		C,--113536699(+) GTAGTC/TGCAGC 3 -- ut311Minor allele frequency- T:0.01WA 118
    rs1402719391,2
    		--113536720(+) GCTAAC/TGTGGG 3 -- ut310--------
    rs124223051,2
    		C,F,A,H,--113536759(+) GTGCAC/TTGACC 3 -- ut31 ese34Minor allele frequency- T:0.15NA 128
    rs1454884081,2
    		--113536795(+) CTGGGA/CAACAG 3 -- ut310--------
    rs124239061,2
    		C,F,H,--113536834(+) taaaaT/GaaaaT 3 -- ut312Minor allele frequency- G:0.16NA 124
    rs789314431,2
    		--113536863(+) GTGGTC/TCTCAA 3 -- ut311Minor allele frequency- T:0.01NA 120
    rs1813160251,2
    		--113536894(+) ACCTAC/TGGAAT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for RASAL1 (113536624 - 113574044 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RASAL1: --

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    Disorders / Diseases
    for RASAL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RASAL1 for disorders           About GeneDecksing

    OMIM gene information: 604118    OMIM disorders: --

    2 diseases for RASAL1:    About MalaCards
    gastric cancer    thyroiditis


    Export disorders for RASAL1 gene to outside databases

    Publications
    for RASAL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASAL1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with RASAL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog. (PubMed id 9751798)1, 2, 3, 9 Allen M.... Buckler A. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. (PubMed id 18992247)1, 9 Ohta M....Omata M. (2009)
    5. A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. (PubMed id 15960973)1, 9 Kolfschoten I.G....Agami R. (2005)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Reduced expression of RAS protein activator like-1 in gastric cancer. (PubMed id 20473946)1 Seto M....Omata M. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for RASAL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing RASAL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8437 HGNC: 9873 AceView: RASAL1 Ensembl:ENSG00000111344 euGenes: HUgn8437
    ECgene: RASAL1 H-InvDB: RASAL1

    Other Databases showing RASAL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RASAL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASAL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASAL1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RASAL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RASAL1 gene:
    Search GeneIP for patents involving RASAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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