Aliases for RASAL1 Gene
External Ids for RASAL1 Gene
Previous GeneCards Identifiers for RASAL1 Gene
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]
GeneCards Summary for RASAL1 Gene
RASAL1 (RAS Protein Activator Like 1) is a Protein Coding gene. Diseases associated with RASAL1 include Ossifying Fibroma and Juvenile Ossifying Fibroma. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity and phospholipid binding. An important paralog of this gene is RASA4.
UniProtKB/Swiss-Prot for RASAL1 Gene
Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003).