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Aliases for RASA4B Gene

Aliases for RASA4B Gene

  • RAS P21 Protein Activator 4B 2 3

External Ids for RASA4B Gene

Previous GeneCards Identifiers for RASA4B Gene

  • GC00U923094
  • GC07M101915
  • GC07M102122
  • GC07M101483

Summaries for RASA4B Gene

GeneCards Summary for RASA4B Gene

RASA4B (RAS P21 Protein Activator 4B) is a Protein Coding gene. Diseases associated with RASA4B include leukemia, acute myelomonocytic, somatic, somatic. Among its related pathways are Ras signaling pathway. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RASA2.

UniProtKB/Swiss-Prot for RASA4B Gene

  • Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASA4B Gene

Genomics for RASA4B Gene

Genomic Location for RASA4B Gene

102,482,445 bp from pter
102,517,781 bp from pter
35,337 bases
Minus strand

Genomic View for RASA4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASA4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASA4B Gene

No data available for Regulatory Elements for RASA4B Gene

Proteins for RASA4B Gene

  • Protein details for RASA4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras GTPase-activating protein 4B
    Protein Accession:

    Protein attributes for RASA4B Gene

    803 amino acids
    Molecular mass:
    90406 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RASA4B Gene

Proteomics data for RASA4B Gene at MOPED

Post-translational modifications for RASA4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASA4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASA4B Gene

Domains & Families for RASA4B Gene

Protein Domains for RASA4B Gene

Suggested Antigen Peptide Sequences for RASA4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Contains 1 Btk-type zinc finger.
  • Contains 2 C2 domains.
  • Contains 1 PH domain.
  • Contains 1 Ras-GAP domain.
  • Contains 1 Btk-type zinc finger.
genes like me logo Genes that share domains with RASA4B: view

Function for RASA4B Gene

Molecular function for RASA4B Gene

UniProtKB/Swiss-Prot Function:
Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway.

Gene Ontology (GO) - Molecular Function for RASA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RASA4B: view

Animal Model Products

CRISPR Products

miRNA for RASA4B Gene

miRTarBase miRNAs that target RASA4B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for RASA4B Gene

Localization for RASA4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASA4B Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for RASA4B Gene COMPARTMENTS Subcellular localization image for RASA4B gene
Compartment Confidence
cytosol 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RASA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IEA --
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA --
genes like me logo Genes that share ontologies with RASA4B: view

Pathways & Interactions for RASA4B Gene

SuperPathways for RASA4B Gene

Superpath Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with RASA4B: view

Pathways by source for RASA4B Gene

1 KEGG pathway for RASA4B Gene

Interacting Proteins for RASA4B Gene

Gene Ontology (GO) - Biological Process for RASA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0035556 intracellular signal transduction IEA --
GO:0043087 regulation of GTPase activity --
GO:0043547 positive regulation of GTPase activity IBA --
GO:0046580 negative regulation of Ras protein signal transduction IBA --
genes like me logo Genes that share ontologies with RASA4B: view

No data available for SIGNOR curated interactions for RASA4B Gene

Drugs & Compounds for RASA4B Gene

No Compound Related Data Available

Transcripts for RASA4B Gene

mRNA/cDNA for RASA4B Gene

Alternative Splicing Database (ASD) splice patterns (SP) for RASA4B Gene

No ASD Table

Relevant External Links for RASA4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASA4B Gene

mRNA expression in normal human tissues for RASA4B Gene

mRNA differential expression in normal tissues according to GTEx for RASA4B Gene

This gene is overexpressed in Muscle - Skeletal (x9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASA4B Gene

genes like me logo Genes that share expression patterns with RASA4B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RASA4B Gene

Orthologs for RASA4B Gene

This gene was present in the common ancestor of animals.

Orthologs for RASA4B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
(Mus musculus)
Mammalia Rasa4 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
-- 36
  • 61 (a)
(Pan troglodytes)
Mammalia -- 36
  • 93 (a)
(Gallus gallus)
Aves -- 36
  • 62 (a)
(Danio rerio)
Actinopterygii rasa4 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gap1 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea gap-1 36
  • 22 (a)
Species with no ortholog for RASA4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RASA4B Gene

Gene Tree for RASA4B (if available)
Gene Tree for RASA4B (if available)

Paralogs for RASA4B Gene

Paralogs for RASA4B Gene

(4) SIMAP similar genes for RASA4B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RASA4B: view

Variants for RASA4B Gene

Sequence variations from dbSNP and Humsavar for RASA4B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs732022 -- 102,494,768(-) GTGTC(C/G)CAGCG intron-variant
rs746316 -- 102,496,157(-) AGTCC(A/G)TGGAG missense, reference, nc-transcript-variant
rs746317 -- 102,496,096(-) ACAAC(A/C/T)CTGAG intron-variant
rs916884 -- 102,484,972(-) ATGGT(A/G)GCTGG intron-variant
rs1060261 -- 102,483,283(-) GGGCC(A/G)CACCC utr-variant-3-prime, nc-transcript-variant

Variation tolerance for RASA4B Gene

Gene Damage Index Score: 11.00; 92.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASA4B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RASA4B Gene

Disorders for RASA4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASA4B Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukemia, acute myelomonocytic, somatic, somatic
  • leukemia, juvenile myelomonocytic, somatic
- elite association

Relevant External Links for RASA4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RASA4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASA4B Gene

Publications for RASA4B Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 67
  2. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. (PMID: 11448776) Lockyer P.J. … Cullen P.J. (Curr. Biol. 2001) 67
  3. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 67

Products for RASA4B Gene

Sources for RASA4B Gene

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