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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASA4B Gene

protein-coding   GIFtS: 26
GCID: GC07M102122

RAS P21 Protein Activator 4B

  Search for RASA4B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAS P21 Protein Activator 4B1 2
Putative Ras GTPase-Activating Protein 4B2

External Ids:    HGNC: 352021   Entrez Gene: 1002719272   Ensembl: ENSG000001706677   UniProtKB: C9J7983   

Export aliases for RASA4B gene to outside databases

Previous GC identifers: GC00U923094 GC07M101915 GC07M101483


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RASA4B Gene: 
RASA4B (RAS p21 protein activator 4B) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and GTPase activator activity. An important paralog of this gene is SYNGAP1.

UniProtKB/Swiss-Prot: RAS4B_HUMAN, C9J798
Function: Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RASA4B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RASA4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASA4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

RASA4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASA4B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M102122:  view genomic region     (about GC identifiers)

Start:
102,122,892 bp from pter      End:
102,184,211 bp from pter
Size:
61,320 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 101,483,887-101,518,525     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: RAS4B_HUMAN, C9J798 (See protein sequence)
Recommended Name: Putative Ras GTPase-activating protein 4B  
Size: 803 amino acids; 90406 Da
Subcellular location: Cytoplasm, cytosol (By similarity). Cell membrane; Peripheral membrane protein (By
similarity)
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for RASA4B: NX_C9J798

Explore proteomics data for RASA4B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_C9J798

  • RASA4B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RASA4B Protein Expression
    REFSEQ proteins: NP_001264264.1  
    ENSEMBL proteins: 
     ENSP00000417895   ENSP00000419967   ENSP00000303968   ENSP00000440982  

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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IEA--

    RASA4B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    5/10 InterPro protein domains (see all 10):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR018029 C2_membr_targeting
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry C9J798

    ProtoNet protein and cluster: C9J798

    UniProtKB/Swiss-Prot: RAS4B_HUMAN, C9J798
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain


    RASA4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAS4B_HUMAN, C9J798
    Function: Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway (By
    similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0046872metal ion binding IEA--
         
    RASA4B for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASA4B

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0035556intracellular signal transduction IEA--
    GO:0051056regulation of small GTPase mediated signal transduction IEA--

    RASA4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about RASA4B / RAS4B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for RASA4B gene: 
    NM_001277335.1  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477184(uc011kkt.1) ENST00000488284(uc003uzr.1 uc003uzv.1)
    ENST00000465829(uc022ajh.1 uc010lia.1 uc003uzu.1 uc003uzt.1 uc010lib.1)
    ENST00000495352 ENST00000481893(uc011kku.1) ENST00000467351 ENST00000306682
    ENST00000541662
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASA4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RASA4B Expression
    About this image


    See RASA4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASA4B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RASA4B gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    65(a)
    1 → many
    19(4168859-4175657)
    zebrafish
    (Danio rerio)
    Actinopterygii rasa46
    RAS p21 protein activator 4
    62(a)
    1 → many
    5(60976757-61084558)
    worm
    (Caenorhabditis elegans)
    Secernentea gap-16
    Ras GTPase-activating protein gap-1
    21(a)
    1 → many
    X(2192504-2195348)
            Species with no ortholog for RASA4B

    ENSEMBL Gene Tree for RASA4B (if available)
    TreeFam Gene Tree for RASA4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASA4B gene
    SYNGAP12  DAB2IP2  RASA42  RASA12  RASAL32  RASA22  RASAL22  RASA32  
    RASAL12  
    4 SIMAP similar genes for RASA4B using alignment to 3 protein entries:     RAS4B_HUMAN (see all proteins):
    RASA4    RASAL1    RASA3    RASA2

    RASA4B for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for RASA4B
    PGOHUM00000232671 PGOHUM00000260213 PGOHUM00000260277 PGOHUM00000232948 PGOHUM00000262011


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/211 SNPs in RASA4B are shown (see all 211)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018460241,2
    C--101492338(+) TGGAGA/GAACTC 4 -- int10--------
    rs773829051,2
    C--101492486(+) CTCTGG/ACCTGG 4 -- int11Minor allele frequency- A:0.50NA 2
    rs1458622511,2
    C--101493156(+) ACTCAC/GAGAGG 4 -- int10--------
    rs2008401211,2
    C--101493372(+) TTTAAA/TCCTCA 4 -- int10--------
    rs3709227781,2
    C--101493615(+) CTCCAC/TTTGGC 4 -- int10--------
    rs1392241191,2
    C--101496827(+) TGTCG-/CTCTCTC 4 -- int10--------
    rs7463171,2
    C,A--101496844(-) ACAACC/ACTGAG 4 -- int11Minor allele frequency- A:0.50NA 2
    rs2005085771,2
    C--101496877(+) TAGCAC/TGCAAC 4 -- int10--------
    rs7463161,2
    C,F,A--101496905(-) AGTCCG/ATGGAG 8 /M /V mis12Minor allele frequency- A:0.01NA EU 305
    rs3739271771,2
    C--101497803(+) TGGGGA/CGGCTT 4 -- int10--------

    HapMap Linkage Disequilibrium report for RASA4B (102122892 - 102184211 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RASA4B: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASA4B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RASA4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    3. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    4. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. (PubMed id 11448776)1 Lockyer P.J.... Cullen P.J. (2001)
    5. Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100271927 HGNC: 35202 Ensembl:ENSG00000170667 euGenes: HUgn100271927 ECgene: RASA4B
    H-InvDB: RASA4B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASA4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RASA4B gene:
    Search GeneIP for patents involving RASA4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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