Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RASA4 Gene

Aliases for RASA4 Gene

  • RAS P21 Protein Activator 4 2 3
  • CAPRI 3 4 6
  • GAPL 3 4 6
  • Calcium-Promoted Ras Inactivator 3 4
  • RasGAP-Activating-Like Protein 2 3 4
  • KIAA0538 4 6
  • Ras GTPase-Activating Protein 4 3
  • Ca2+-Promoted Ras Inactivator 3
  • Ras P21 Protein Activator 4 4

External Ids for RASA4 Gene

Summaries for RASA4 Gene

Entrez Gene Summary for RASA4 Gene

  • This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASA4 Gene

RASA4 (RAS P21 Protein Activator 4) is a Protein Coding gene. Among its related pathways are Ras signaling pathway. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is RASA2.

UniProtKB/Swiss-Prot for RASA4 Gene

  • Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.

Gene Wiki entry for RASA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASA4 Gene

Genomics for RASA4 Gene

Genomic Location for RASA4 Gene

Start:
102,573,807 bp from pter
End:
102,616,758 bp from pter
Size:
42,952 bases
Orientation:
Minus strand

Genomic View for RASA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASA4 Gene

Regulatory Elements for RASA4 Gene

Proteins for RASA4 Gene

  • Protein details for RASA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43374-RASL2_HUMAN
    Recommended name:
    Ras GTPase-activating protein 4
    Protein Accession:
    O43374
    Secondary Accessions:
    • O60286
    • Q14CQ4
    • Q86UW3
    • Q96QU0

    Protein attributes for RASA4 Gene

    Size:
    803 amino acids
    Molecular mass:
    90458 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB97935.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAP22345.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA25464.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASA4 Gene

Proteomics data for RASA4 Gene at MOPED

Post-translational modifications for RASA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASA4 Gene

Domains for RASA4 Gene

UniProtKB/Swiss-Prot:

RASL2_HUMAN
Domain:
  • The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members:
    • O43374
  • Contains 2 C2 domains.:
    • O43374
  • Contains 1 PH domain.:
    • O43374
  • Contains 1 Ras-GAP domain.:
    • O43374
Similarity:
  • Contains 1 Btk-type zinc finger.:
    • O43374
genes like me logo Genes that share domains with RASA4: view

No data available for Gene Families for RASA4 Gene

Function for RASA4 Gene

Molecular function for RASA4 Gene

UniProtKB/Swiss-Prot Function: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.

Gene Ontology (GO) - Molecular Function for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 11448776
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RASA4: view
genes like me logo Genes that share phenotypes with RASA4: view

Animal Models for RASA4 Gene

MGI Knock Outs for RASA4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RASA4 Gene

Localization for RASA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASA4 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASA4 Gene COMPARTMENTS Subcellular localization image for RASA4 gene
Compartment Confidence
cytosol 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA 16009725
GO:0005886 colocalizes_with plasma membrane IDA 16009725
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA --
genes like me logo Genes that share ontologies with RASA4: view

Pathways for RASA4 Gene

SuperPathways for RASA4 Gene

Superpath Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with RASA4: view

Pathways by source for RASA4 Gene

1 KEGG pathway for RASA4 Gene

Gene Ontology (GO) - Biological Process for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0034260 negative regulation of GTPase activity IMP 11448776
GO:0035556 intracellular signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0046580 negative regulation of Ras protein signal transduction IBA --
genes like me logo Genes that share ontologies with RASA4: view

Compounds for RASA4 Gene

(1) HMDB Compounds for RASA4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with RASA4: view

Transcripts for RASA4 Gene

mRNA/cDNA for RASA4 Gene

Unigene Clusters for RASA4 Gene

RAS p21 protein activator 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RASA4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7: -
SP8: - - -
SP9: - - -
SP10:
SP11: - - -
SP12: -
SP13:
SP14:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11: - -
SP12: - -
SP13: - -
SP14:

Relevant External Links for RASA4 Gene

GeneLoc Exon Structure for
RASA4
ECgene alternative splicing isoforms for
RASA4

Expression for RASA4 Gene

mRNA expression in normal human tissues for RASA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASA4 Gene

This gene is overexpressed in Muscle - Skeletal (9.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASA4 Gene

SOURCE GeneReport for Unigene cluster for RASA4 Gene Hs.530089

mRNA Expression by UniProt/SwissProt for RASA4 Gene

O43374-RASL2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with RASA4: view

Orthologs for RASA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 99 (a)
OneToMany
LOC742087 36
  • 99.29 (n)
  • 98.88 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 90 (a)
OneToMany
RASA4 36
  • 89.53 (n)
  • 89.9 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 85 (a)
OneToMany
RASA4 36
  • 89.53 (n)
  • 90.65 (a)
mouse
(Mus musculus)
Mammalia Rasa4 36
  • 84.37 (n)
  • 86.41 (a)
Rasa4 16
Rasa4 37
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 66 (a)
ManyToMany
-- 37
  • 69 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rasa4 36
  • 84.62 (n)
  • 87.66 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 66 (a)
OneToMany
RASA4 36
  • 74.06 (n)
  • 69.06 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488193 36
  • 63.94 (n)
  • 69.44 (a)
zebrafish
(Danio rerio)
Actinopterygii rasa4 36
  • 64.49 (n)
  • 62.23 (a)
rasa4 37
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Gap1 37
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gap-1 37
  • 23 (a)
OneToMany
Species with no ortholog for RASA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASA4 Gene

ENSEMBL:
Gene Tree for RASA4 (if available)
TreeFam:
Gene Tree for RASA4 (if available)

Paralogs for RASA4 Gene

Paralogs for RASA4 Gene

Pseudogenes.org Pseudogenes for RASA4 Gene

genes like me logo Genes that share paralogs with RASA4: view

Variants for RASA4 Gene

Sequence variations from dbSNP and Humsavar for RASA4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1060228 - 102,584,251(-) CATCT(A/G)CCGGC reference, missense, nc-transcript-variant
rs2008962 -- 102,588,965(-) aaaaa(A/C/G)aaaaa intron-variant
rs2189266 -- 102,586,566(-) AGGAC(G/T)CCATA intron-variant
rs2898626 -- 102,587,438(+) TGTGA(A/T)GCATA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs4236561 -- 102,588,822(+) accac(A/G)cccag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASA4 Gene

Variant ID Type Subtype PubMed ID
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
dgv7412n71 CNV Loss 21882294
nsv5879 CNV Loss 18451855
nsv8192 CNV Gain 18304495
esv27624 CNV Gain+Loss 19812545
nsv888836 CNV Loss 21882294
dgv7414n71 CNV Gain+Loss 21882294
dgv7415n71 CNV Gain+Loss 21882294
dgv7416n71 CNV Gain 21882294
dgv7417n71 CNV Gain 21882294
nsv888845 CNV Gain 21882294
dgv23n31 CNV Duplication 19718026
nsv499529 CNV Loss 21111241
nsv433392 CNV Gain 18776910
nsv436086 CNV Insertion 17901297
nsv436552 CNV Deletion 17901297
dgv7418n71 CNV Gain 21882294
esv2734946 CNV Deletion 23290073
nsv888865 CNV Loss 21882294
dgv7419n71 CNV Loss 21882294
dgv7420n71 CNV Gain 21882294
esv7079 CNV Loss 19470904
nsv888868 CNV Loss 21882294
dgv7421n71 CNV Gain+Loss 21882294
nsv888872 CNV Gain+Loss 21882294
nsv469682 CNV Complex 16826518
nsv471643 CNV Gain+Loss 15918152
nsv509219 CNV Insertion 20534489
dgv7422n71 CNV Loss 21882294
dgv7423n71 CNV Loss 21882294
nsv888877 CNV Loss 21882294
nsv888881 CNV Gain+Loss 21882294
dgv7424n71 CNV Gain 21882294
nsv471451 CNV Duplication 19718026
nsv482112 CNV Gain 20164927
dgv7425n71 CNV Loss 21882294
nsv9 CNV Loss 15895083
nsv499135 CNV Loss 21111241
dgv7426n71 CNV Loss 21882294
dgv7427n71 CNV Gain+Loss 21882294
dgv7428n71 CNV Gain+Loss 21882294
nsv888899 CNV Gain+Loss 21882294
dgv7429n71 CNV Loss 21882294
dgv7430n71 CNV Gain+Loss 21882294
dgv7431n71 CNV Loss 21882294
dgv7432n71 CNV Loss 21882294
nsv888907 CNV Gain+Loss 21882294
dgv7433n71 CNV Loss 21882294
nsv888910 CNV Loss 21882294
dgv7434n71 CNV Loss 21882294
nsv888915 CNV Loss 21882294
nsv888917 CNV Gain+Loss 21882294
dgv7435n71 CNV Gain 21882294
nsv888921 CNV Gain 21882294

Relevant External Links for RASA4 Gene

HapMap Linkage Disequilibrium report
RASA4

Disorders for RASA4 Gene

No disorders were found for RASA4 Gene.

No data available for UniProtKB/Swiss-Prot for RASA4 Gene

Publications for RASA4 Gene

  1. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. (PMID: 11448776) Lockyer P.J. … Cullen P.J. (Curr. Biol. 2001) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RASA4 Gene

Sources for RASA4 Gene

Back to Top

Content