Aliases for RASA4 Gene
External Ids for RASA4 Gene
Previous GeneCards Identifiers for RASA4 Gene
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RASA4 Gene
RASA4 (RAS P21 Protein Activator 4) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by PTK6. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RASAL1.
UniProtKB/Swiss-Prot for RASA4 Gene
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.