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RASA4 Gene

protein-coding   GIFtS: 57
GCID: GC07M102220

RAS P21 Protein Activator 4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAS P21 Protein Activator 41 2 3     RasGAP-Activating-Like Protein 22 3
CAPRI2 3 5     KIAA05383 5
GAPL2 3 5     Ca2+-Promoted Ras Inactivator2
Calcium-Promoted Ras Inactivator2 3     Ras GTPase-Activating Protein 42

External Ids:    HGNC: 231811   Entrez Gene: 101562   Ensembl: ENSG000001058087   OMIM: 6079435   UniProtKB: O433743   

Export aliases for RASA4 gene to outside databases

Previous GC identifers: GC07M101781 GC07M101782 GC07M101813 GC07M102001 GC07M102007 GC07M043952


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RASA4 Gene:
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the
Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+)
levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase
activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no
longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RASA4 Gene:
RASA4 (RAS p21 protein activator 4) is a protein-coding gene. Diseases associated with RASA4 include pleuropneumonia. GO annotations related to this gene include phospholipid binding and Ras GTPase activator activity. An important paralog of this gene is SYNGAP1.

UniProtKB/Swiss-Prot: RASL2_HUMAN, O43374
Function: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a
stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated
phagocytosis

Gene Wiki entry for RASA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASA4 gene promoter:
         NF-YA   Lmo2   NF-YB   c-Rel   CBF-B   CBF-A   HOXA5   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RASA4 promoter sequence
   Search Chromatin IP Primers for RASA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22-q31.1

RASA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASA4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M102220:  view genomic region     (about GC identifiers)

Start:
102,220,093 bp from pter      End:
102,257,205 bp from pter
Size:
37,113 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 101,580,464-101,617,574     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RASL2_HUMAN, O43374 (See protein sequence)
Recommended Name: Ras GTPase-activating protein 4  
Size: 803 amino acids; 90458 Da
Sequence caution: Sequence=AAB97935.2; Type=Erroneous gene model prediction; Sequence=AAP22345.1; Type=Erroneous
gene model prediction; Sequence=BAA25464.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O60286 Q14CQ4 Q86UW3 Q96QU0
Alternative splicing: 2 isoforms:  O43374-1   O43374-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RASA4: NX_O43374

Explore proteomics data for RASA4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001073346.2  NP_008920.5  

    ENSEMBL proteins: 
     ENSP00000262940   ENSP00000420352   ENSP00000412876   ENSP00000417395   ENSP00000428605  
     ENSP00000430337   ENSP00000430418   ENSP00000428732   ENSP00000428448  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR023152 RasGAP_CS

    Graphical View of Domain Structure for InterPro Entry O43374

    ProtoNet protein and cluster: O43374

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: RASL2_HUMAN, O43374
    Domain: The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol
    3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family
    members
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain


    RASA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASL2_HUMAN, O43374
    Function: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a
    stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated
    phagocytosis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IDA11448776
    GO:0005099Ras GTPase activator activity IBA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    RASA4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RASA4:
     Increased cell transformation  Upregulation of NF-kappaB path 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rasa4):
     hematopoietic system  immune system 

    RASA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rasa4tm1Ywh for RASA4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASA4
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    hsa-miR-657 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidRASA4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RASL2_HUMAN, O43374: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the
    cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium
    mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol IEA--
    GO:0031235intrinsic component of the cytoplasmic side of the plasma membrane IBA--

    RASA4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RASA4 About    
    See pathways by source

    SuperPathContained pathways About
    1Ras signaling pathway
    Ras signaling pathway0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for RASA4):
        Ras signaling pathway


    RASA4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASA4
    Interactions:

        Search GeneGlobe Interaction Network for RASA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for RASA4 (O433742, 3 ENSP000002629404) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APMAPQ9HDC92, 3MINT-63139 I2D: score=3 
    CRAMP1LQ96RY52, 3MINT-63138 I2D: score=1 
    OVGP1Q128892, 3, ENSP000003587474MINT-63137 I2D: score=3 STRING: ENSP00000358747
    ERBB3P218602, 3, ENSP000002671014MINT-63136 I2D: score=3 STRING: ENSP00000267101
    HN1LQ9H9103I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0032320positive regulation of Ras GTPase activity IBA--
    GO:0035556intracellular signal transduction IEA--
    GO:0046580negative regulation of Ras protein signal transduction IBA--
    GO:0051056regulation of small GTPase mediated signal transduction ----

    RASA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASA4 (RASL2)

    1 HMDB Compound for RASA4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RASA4 gene (2 alternative transcripts): 
    NM_001079877.2  NM_006989.5  

    Unigene Cluster for RASA4:

    RAS p21 protein activator 4
    Hs.530089  [show with all ESTs]
    Unigene Representative Sequence: NM_006989
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262940(uc011kky.2 uc011kkz.2 uc011kla.2 uc010lig.3 uc003vae.3 uc003vaf.3 uc011klb.2)
    ENST00000461209 ENST00000449970 ENST00000522223 ENST00000462172(uc011kld.1)
    ENST00000523568(uc011klc.1 uc010lih.2) ENST00000521822 ENST00000521397
    ENST00000520577 ENST00000519539 ENST00000522801 ENST00000519878 ENST00000520042
    ENST00000521076 ENST00000522443 ENST00000521892
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate RASA4:
    hsa-miR-657 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidRASA4 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RASA4
      QuantiFast Probe-based Assays in human, mouse, rat RASA4

    Additional mRNA sequence: 

    AB011110.2 AK026441.1 AK093486.1 AK301666.1 AK308653.1 AK310176.1 AK315928.1 BC110873.1 
    BC113663.1 BC143584.1 BC143585.1 

    Selected DOTS entries (see all 34):

    DT.450079  DT.109323  DT.121040347  DT.95298751  DT.100804097  DT.100804095  DT.100703051  DT.100683608 
    DT.97818880  DT.100804093  DT.92439249  DT.121040311  DT.92439252  DT.97862047  DT.97862049  DT.100768827 
    DT.102839826  DT.121040397  DT.100804088  DT.101963045  DT.102840216  DT.121040267  DT.121040468  DT.121040856 

    7 AceView cDNA sequences:

    BM698658 BQ896855 BU731028 BI910228 BE549500 AI378796 NM_006989 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RASA4 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -                           
    SP4:                                                                                                                                -                           
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:  -     -                                 
    SP5:                                          


    ECgene alternative splicing isoforms for RASA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGCCGGA
    RASA4 Expression
    About this image


    RASA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Retina
    RASA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530089

    UniProtKB/Swiss-Prot: RASL2_HUMAN, O43374
    Tissue specificity: Widely expressed

        Custom PCR Arrays for RASA4
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASA4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasa41 , 5 RAS p21 protein activator 41, 5 84.37(n)1
    86.41(a)1
      5 (75.76 cM)5
    541531  NM_133914.31  NP_598675.21 
     1360839165 
    chicken
    (Gallus gallus)
    Aves RASA41 RAS p21 protein activator 4 74.06(n)
    69.06(a)
      417513  XM_415761.4  XP_415761.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004881931 ras GTPase-activating protein 4-like 63.94(n)
    69.44(a)
      100488193  XM_002933827.2  XP_002933873.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rasa41 RAS p21 protein activator 4 64.49(n)
    62.23(a)
      567599  NM_001099451.1  NP_001092921.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gap16
    GTPase-activating protein 1
    19(a)
    1 → many
    3L(9832193-9848385)
    worm
    (Caenorhabditis elegans)
    Secernentea gap-16
    Protein GAP-1 (gap-1) mRNA, complete cds
    23(a)
    1 → many
    X(2192504-2195348) WBGene00001515


    ENSEMBL Gene Tree for RASA4 (if available)
    TreeFam Gene Tree for RASA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASA4 gene
    SYNGAP12  RASA22  RASA4B2  DAB2IP2  RASA32  RASAL22  RASA12  RASAL12  
    RASAL32  
    9 SIMAP similar genes for RASA4 using alignment to 9 protein entries:     RASL2_HUMAN (see all proteins):
    RASA4B    PRKCB    RASAL1    PRKCA    PRKCG    PCLO
    RASA3    RASA2    SYT7

    RASA4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RASA4
    PGOHUM00000250860


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASA4 (see all 175)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437526701,2
    C--102219690(+) AGATGC/TGCACC 2 -- ds50010--------
    rs1996101011,2
    C--102220287(+) TGCAGA/CAAATC 2 -- ut310--------
    rs1489985611,2
    C--102221406(+) CCTCCC/TTTCTG 2 -- ut310--------
    rs2012067521,2
    F--102224698(+) GCCGGC/TAGATG 4 Y C mis11Minor allele frequency- T:0.01EU 237
    rs2008169871,2
    C--102227504(+) GCACCA/GCTGCA 2 -- int10--------
    rs2003367781,2
    --102227546(+) ATCAA-/ACAACAA 2 -- int10--------
    rs1510491071,2
    C--102229231(+) CTCAGC/TCCCCC 2 -- int10--------
    rs42365611,2
    C,A--102229269(+) accacA/Gcccag 2 -- int10--------
    rs1503401811,2
    C--102229704(+) AAACAC/TGTATT 2 -- int10--------
    rs1495301591,2
    C--102231022(+) CAATCC/TGGCCG 2 -- int10--------

    HapMap Linkage Disequilibrium report for RASA4 (102220093 - 102257205 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RASA4 (see all 55):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436552CNV Deletion17901297
    esv2734946CNV Deletion23290073
    dgv23n31CNV Duplication19718026
    nsv471451CNV Duplication19718026
    nsv509219CNV Insertion20534489
    nsv436086CNV Insertion17901297
    dgv7426n71CNV Loss21882294
    nsv5879CNV Loss18451855
    nsv888877CNV Loss21882294
    dgv7412n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASA4
    DNA2.0 Custom Variant and Variant Library Synthesis for RASA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607943    OMIM disorders: --

    1 disease for RASA4:    
    About MalaCards
    pleuropneumonia


    RASA4 for disorders           About GeneDecksing


    Export disorders for RASA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASA4 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with RASA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. (PubMed id 11448776)1, 2, 3 Lockyer P.J.... Cullen P.J. (Curr. Biol. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    6. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities. (PubMed id 21460216)1 Dai Y....Lockyer P.J. (J. Biol. Chem. 2011)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10156 HGNC: 23181 AceView: RASA4 Ensembl:ENSG00000105808 euGenes: HUgn10156
    ECgene: RASA4 Kegg: 10156 H-InvDB: RASA4

    (According to HUGE)
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    HUGE: KIAA0538

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RASA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RASA4 gene:
    Search GeneIP for patents involving RASA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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