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Aliases for RASA4 Gene

Aliases for RASA4 Gene

  • RAS P21 Protein Activator 4 2 3
  • Calcium-Promoted Ras Inactivator 3 4
  • RasGAP-Activating-Like Protein 2 3 4
  • Ras P21 Protein Activator 4 4 5
  • CAPRI 3 4
  • GAPL 3 4
  • Ras GTPase-Activating Protein 4 3
  • Ca2+-Promoted Ras Inactivator 3
  • KIAA0538 4

External Ids for RASA4 Gene

Previous GeneCards Identifiers for RASA4 Gene

  • GC07M101781
  • GC07M101782
  • GC07M101813
  • GC07M102001
  • GC07M102007
  • GC07M102220
  • GC07M043952

Summaries for RASA4 Gene

Entrez Gene Summary for RASA4 Gene

  • This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASA4 Gene

RASA4 (RAS P21 Protein Activator 4) is a Protein Coding gene. Among its related pathways are RET signaling and Signaling by PTK6. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RASA4B.

UniProtKB/Swiss-Prot for RASA4 Gene

  • Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.

Gene Wiki entry for RASA4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASA4 Gene

Genomics for RASA4 Gene

Regulatory Elements for RASA4 Gene

Enhancers for RASA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G102713 1.3 Ensembl ENCODE dbSUPER 20 -97.9 -97870 3.3 CTCF FEZF1 BMI1 ZBTB40 ARID3A ZNF143 PRDM10 RELB IKZF2 ZNF263 POLR2J2 RASA4 RASA4DP FAM185A
GH07G102748 1.1 ENCODE 14.2 -132.3 -132328 1.7 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 POLR2J2 RASA4DP RASA4 FBXL13 ARMC10 POLR2J FAM185A RPL7AP39
GH07G102912 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.1 -298.6 -298550 6.0 ELF3 CTCF PKNOX1 JUN SIN3A RAD21 ZNF316 ZNF366 POLR2A ZNF547 RNU6-1136P FBXL13 DPY19L2P2 ARMC10 LRRC17 RASA4 RPL23AP95 NFE4
GH07G102987 1.6 Ensembl ENCODE dbSUPER 5.7 -374.6 -374607 6.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT SIN3A FEZF1 ZNF2 ZNF766 CBX5 PRKRIP1 ENSG00000213385 CRYZP1 ALKBH4 NAPEPLD PMPCB LRRC17 ARMC10 ENSG00000239486 RASA4
GH07G102671 0.7 ENCODE 7.4 -55.1 -55077 0.9 HDAC1 CTCF RB1 SIN3A ZBTB40 ZNF366 EGR1 POLR2A ZBTB2 NRF1 RASA4 POLR2J2 ENSG00000279168
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RASA4 on UCSC Golden Path with GeneCards custom track

Promoters for RASA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000327581 58 1001 RB1

Genomic Location for RASA4 Gene

Chromosome:
7
Start:
102,573,807 bp from pter
End:
102,616,758 bp from pter
Size:
42,952 bases
Orientation:
Minus strand

Genomic View for RASA4 Gene

Genes around RASA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASA4 Gene

Proteins for RASA4 Gene

  • Protein details for RASA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43374-RASL2_HUMAN
    Recommended name:
    Ras GTPase-activating protein 4
    Protein Accession:
    O43374
    Secondary Accessions:
    • O60286
    • Q14CQ4
    • Q86UW3
    • Q96QU0

    Protein attributes for RASA4 Gene

    Size:
    803 amino acids
    Molecular mass:
    90458 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB97935.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAP22345.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA25464.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASA4 Gene

Post-translational modifications for RASA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASA4 Gene

Domains & Families for RASA4 Gene

Gene Families for RASA4 Gene

Graphical View of Domain Structure for InterPro Entry

O43374

UniProtKB/Swiss-Prot:

RASL2_HUMAN :
  • The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members.
Domain:
  • The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members.
genes like me logo Genes that share domains with RASA4: view

Function for RASA4 Gene

Molecular function for RASA4 Gene

UniProtKB/Swiss-Prot Function:
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.

Gene Ontology (GO) - Molecular Function for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA,IEA 11448776
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RASA4: view
genes like me logo Genes that share phenotypes with RASA4: view

Animal Models for RASA4 Gene

MGI Knock Outs for RASA4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASA4 Gene

Localization for RASA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASA4 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASA4 gene
Compartment Confidence
cytosol 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 colocalizes_with plasma membrane IDA,IEA 16009725
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASA4: view

Pathways & Interactions for RASA4 Gene

SuperPathways for RASA4 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 HIV Life Cycle
.45
5 Innate Immune System
genes like me logo Genes that share pathways with RASA4: view

Pathways by source for RASA4 Gene

Gene Ontology (GO) - Biological Process for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction IEA --
GO:0034260 negative regulation of GTPase activity IMP 11448776
GO:0035556 intracellular signal transduction IEA --
GO:0043087 regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RASA4: view

No data available for SIGNOR curated interactions for RASA4 Gene

Drugs & Compounds for RASA4 Gene

(2) Drugs for RASA4 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Salirasib Pharma Inhibitor of active Ras protein 0
calcium Nutra 0

(1) ApexBio Compounds for RASA4 Gene

Compound Action Cas Number
Salirasib Inhibitor of active Ras protein 162520-00-5
genes like me logo Genes that share compounds with RASA4: view

Drug Products

Transcripts for RASA4 Gene

mRNA/cDNA for RASA4 Gene

Unigene Clusters for RASA4 Gene

RAS p21 protein activator 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASA4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7: -
SP8: - - -
SP9: - - -
SP10:
SP11: - - -
SP12: -
SP13:
SP14:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11: - -
SP12: - -
SP13: - -
SP14:

Relevant External Links for RASA4 Gene

GeneLoc Exon Structure for
RASA4
ECgene alternative splicing isoforms for
RASA4

Expression for RASA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASA4 Gene

This gene is overexpressed in Muscle - Skeletal (x9.9).

Protein differential expression in normal tissues from HIPED for RASA4 Gene

This gene is overexpressed in Ovary (20.7), Prostate (20.5), Urinary Bladder (14.7), and Retina (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASA4 Gene



Protein tissue co-expression partners for RASA4 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASA4 Gene:

RASA4

SOURCE GeneReport for Unigene cluster for RASA4 Gene:

Hs.530089

mRNA Expression by UniProt/SwissProt for RASA4 Gene:

O43374-RASL2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for RASA4 Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Liver(4)
genes like me logo Genes that share expression patterns with RASA4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASA4 Gene

Orthologs for RASA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC742087 34
  • 99.29 (n)
-- 35
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 90 (a)
OneToMany
RASA4 34
  • 89.53 (n)
dog
(Canis familiaris)
Mammalia RASA4 34
  • 89.53 (n)
-- 35
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rasa4 34
  • 84.62 (n)
mouse
(Mus musculus)
Mammalia Rasa4 34 16 35
  • 84.37 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RASA4 34
  • 74.06 (n)
-- 35
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488193 34
  • 63.94 (n)
zebrafish
(Danio rerio)
Actinopterygii rasa4 34 35
  • 64.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gap1 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gap-1 35
  • 23 (a)
OneToMany
Species where no ortholog for RASA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASA4 Gene

ENSEMBL:
Gene Tree for RASA4 (if available)
TreeFam:
Gene Tree for RASA4 (if available)

Paralogs for RASA4 Gene

Paralogs for RASA4 Gene

genes like me logo Genes that share paralogs with RASA4: view

Variants for RASA4 Gene

Sequence variations from dbSNP and Humsavar for RASA4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1003473758 -- 102,612,371(+) GAACT(G/T)ATGAG intron-variant
rs1004679248 -- 102,603,865(+) ACCAC(A/C)AAAAA intron-variant
rs1005660489 -- 102,612,329(+) GGCAG(-/C)CCCAT intron-variant
rs1006043556 -- 102,596,457(+) ACACT(G/T)TACAG intron-variant
rs1012904728 -- 102,613,734(+) TTCTA(A/G)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASA4 Gene

Variant ID Type Subtype PubMed ID
dgv11541n54 CNV loss 21841781
dgv11542n54 CNV loss 21841781
dgv11543n54 CNV loss 21841781
dgv11544n54 CNV loss 21841781
dgv11545n54 CNV loss 21841781
dgv11546n54 CNV loss 21841781
dgv11547n54 CNV loss 21841781
dgv11548n54 CNV loss 21841781
dgv11549n54 CNV loss 21841781
dgv11550n54 CNV loss 21841781
dgv11551n54 CNV loss 21841781
dgv1944e212 CNV loss 25503493
dgv23n31 CNV gain 19718026
dgv3894e59 CNV duplication 20981092
dgv3902e59 CNV duplication 20981092
dgv3903e59 CNV duplication 20981092
dgv3904e59 CNV duplication 20981092
dgv3905e59 CNV duplication 20981092
dgv6538n100 CNV gain 25217958
dgv6539n100 CNV gain 25217958
dgv6540n100 CNV gain 25217958
esv2734946 CNV deletion 23290073
esv27624 CNV gain+loss 19812545
esv2764015 CNV loss 21179565
esv3353259 CNV duplication 20981092
esv3358316 CNV duplication 20981092
esv3384577 CNV duplication 20981092
esv3397016 CNV duplication 20981092
esv3411488 CNV duplication 20981092
esv3425603 CNV duplication 20981092
esv3891167 CNV loss 25118596
esv3891168 CNV gain+loss 25118596
esv3891169 CNV gain+loss 25118596
esv3891171 CNV loss 25118596
esv7079 CNV loss 19470904
nsv1077498 CNV duplication 25765185
nsv1110493 CNV duplication 24896259
nsv1119230 CNV duplication 24896259
nsv1128956 CNV duplication 24896259
nsv1128957 CNV duplication 24896259
nsv1139905 CNV duplication 24896259
nsv1148488 CNV duplication 26484159
nsv1149852 CNV duplication 26484159
nsv1152853 CNV duplication 26484159
nsv1153073 CNV duplication 26484159
nsv428182 CNV gain 18775914
nsv433392 CNV gain 18776910
nsv436086 CNV insertion 17901297
nsv436552 CNV deletion 17901297
nsv469682 CNV gain+loss 16826518
nsv471451 CNV gain 19718026
nsv471643 CNV gain+loss 15918152
nsv482112 CNV gain 20164927
nsv499135 CNV loss 21111241
nsv499529 CNV loss 21111241
nsv509219 CNV insertion 20534489
nsv5879 CNV deletion 18451855
nsv608005 CNV gain 21841781
nsv608046 CNV loss 21841781
nsv608048 CNV loss 21841781
nsv608054 CNV loss 21841781
nsv8192 CNV gain 18304495
nsv831083 CNV loss 17160897
nsv9 CNV deletion 15895083
nsv981563 CNV duplication 23825009

Variation tolerance for RASA4 Gene

Gene Damage Index Score: 0.41; 9.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASA4 Gene

Disorders for RASA4 Gene

Relevant External Links for RASA4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASA4

No disorders were found for RASA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASA4 Gene

Publications for RASA4 Gene

  1. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. (PMID: 11448776) Lockyer P.J. … Cullen P.J. (Curr. Biol. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64

Products for RASA4 Gene

Sources for RASA4 Gene

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