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Aliases for RASA4 Gene

Aliases for RASA4 Gene

  • RAS P21 Protein Activator 4 2 3
  • Calcium-Promoted Ras Inactivator 3 4
  • RasGAP-Activating-Like Protein 2 3 4
  • CAPRI 3 4
  • GAPL 3 4
  • Ca2+-Promoted Ras Inactivator 3
  • Ras P21 Protein Activator 4 4
  • KIAA0538 4

External Ids for RASA4 Gene

Previous GeneCards Identifiers for RASA4 Gene

  • GC07M101781
  • GC07M101782
  • GC07M101813
  • GC07M102001
  • GC07M102007
  • GC07M102220
  • GC07M043952

Summaries for RASA4 Gene

Entrez Gene Summary for RASA4 Gene

  • This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASA4 Gene

RASA4 (RAS P21 Protein Activator 4) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RASA2.

UniProtKB/Swiss-Prot for RASA4 Gene

  • Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.

Gene Wiki entry for RASA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASA4 Gene

Genomics for RASA4 Gene

Regulatory Elements for RASA4 Gene

Genomic Location for RASA4 Gene

Chromosome:
7
Start:
102,573,807 bp from pter
End:
102,616,758 bp from pter
Size:
42,952 bases
Orientation:
Minus strand

Genomic View for RASA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASA4 Gene

Proteins for RASA4 Gene

  • Protein details for RASA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43374-RASL2_HUMAN
    Recommended name:
    Ras GTPase-activating protein 4
    Protein Accession:
    O43374
    Secondary Accessions:
    • O60286
    • Q14CQ4
    • Q86UW3
    • Q96QU0

    Protein attributes for RASA4 Gene

    Size:
    803 amino acids
    Molecular mass:
    90458 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB97935.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAP22345.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA25464.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASA4 Gene

Proteomics data for RASA4 Gene at MOPED

Post-translational modifications for RASA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASA4 Gene

Domains & Families for RASA4 Gene

Gene Families for RASA4 Gene

Graphical View of Domain Structure for InterPro Entry

O43374

UniProtKB/Swiss-Prot:

RASL2_HUMAN :
  • The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members
  • Contains 1 Btk-type zinc finger.
Domain:
  • The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members
  • Contains 2 C2 domains.
  • Contains 1 PH domain.
  • Contains 1 Ras-GAP domain.
Similarity:
  • Contains 1 Btk-type zinc finger.
genes like me logo Genes that share domains with RASA4: view

Function for RASA4 Gene

Molecular function for RASA4 Gene

UniProtKB/Swiss-Prot Function:
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.

Gene Ontology (GO) - Molecular Function for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 11448776
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RASA4: view

Phenotypes for RASA4 Gene

genes like me logo Genes that share phenotypes with RASA4: view

Animal Models for RASA4 Gene

MGI Knock Outs for RASA4:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASA4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RASA4 Gene

Localization for RASA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASA4 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASA4 Gene COMPARTMENTS Subcellular localization image for RASA4 gene
Compartment Confidence
cytosol 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 colocalizes_with plasma membrane IDA 16009725
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA --
genes like me logo Genes that share ontologies with RASA4: view

Pathways & Interactions for RASA4 Gene

SuperPathways for RASA4 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Immune System
3 Signaling by GPCR
4 Developmental Biology
5 Ras signaling pathway
genes like me logo Genes that share pathways with RASA4: view

Pathways by source for RASA4 Gene

Gene Ontology (GO) - Biological Process for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0007165 signal transduction --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RASA4: view

No data available for SIGNOR curated interactions for RASA4 Gene

Drugs & Compounds for RASA4 Gene

(2) Drugs for RASA4 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Salirasib Pharma Inhibitor of active Ras protein, Ras inhibitor; also induces autophagy 0
Calcium Nutra 0
genes like me logo Genes that share compounds with RASA4: view

Transcripts for RASA4 Gene

mRNA/cDNA for RASA4 Gene

Unigene Clusters for RASA4 Gene

RAS p21 protein activator 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASA4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7: -
SP8: - - -
SP9: - - -
SP10:
SP11: - - -
SP12: -
SP13:
SP14:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11: - -
SP12: - -
SP13: - -
SP14:

Relevant External Links for RASA4 Gene

GeneLoc Exon Structure for
RASA4
ECgene alternative splicing isoforms for
RASA4

Expression for RASA4 Gene

mRNA expression in normal human tissues for RASA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASA4 Gene

This gene is overexpressed in Muscle - Skeletal (x9.9).

Protein differential expression in normal tissues from HIPED for RASA4 Gene

This gene is overexpressed in Ovary (20.7), Prostate (20.5), Urinary Bladder (14.7), and Retina (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASA4 Gene



SOURCE GeneReport for Unigene cluster for RASA4 Gene Hs.530089

mRNA Expression by UniProt/SwissProt for RASA4 Gene

O43374-RASL2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RASA4: view

Protein tissue co-expression partners for RASA4 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for RASA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASA4 35
  • 89.53 (n)
  • 89.9 (a)
-- 36
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RASA4 35
  • 89.53 (n)
  • 90.65 (a)
-- 36
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rasa4 35
  • 84.37 (n)
  • 86.41 (a)
Rasa4 16
Rasa4 36
  • 86 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC742087 35
  • 99.29 (n)
  • 98.88 (a)
-- 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rasa4 35
  • 84.62 (n)
  • 87.66 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RASA4 35
  • 74.06 (n)
  • 69.06 (a)
-- 36
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488193 35
  • 63.94 (n)
  • 69.44 (a)
zebrafish
(Danio rerio)
Actinopterygii rasa4 35
  • 64.49 (n)
  • 62.23 (a)
rasa4 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Gap1 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gap-1 36
  • 23 (a)
OneToMany
Species with no ortholog for RASA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASA4 Gene

ENSEMBL:
Gene Tree for RASA4 (if available)
TreeFam:
Gene Tree for RASA4 (if available)

Paralogs for RASA4 Gene

Paralogs for RASA4 Gene

Pseudogenes.org Pseudogenes for RASA4 Gene

genes like me logo Genes that share paralogs with RASA4: view

Variants for RASA4 Gene

Sequence variations from dbSNP and Humsavar for RASA4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2008962 -- 102,588,965(-) aaaaa(A/C/G)aaaaa intron-variant
rs2411011 -- 102,591,127(-) AACTT(G/T)TTTTT intron-variant
rs2522860 -- 102,592,796(-) CCTGC(C/T)GTTGA intron-variant
rs3889693 -- 102,594,836(-) catag(G/T)gagac intron-variant
rs3948722 -- 102,589,668(-) ATCCC(C/T)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASA4 Gene

Variant ID Type Subtype PubMed ID
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
dgv7412n71 CNV Loss 21882294
nsv5879 CNV Loss 18451855
nsv8192 CNV Gain 18304495
esv27624 CNV Gain+Loss 19812545
nsv888836 CNV Loss 21882294
dgv7414n71 CNV Gain+Loss 21882294
dgv7415n71 CNV Gain+Loss 21882294
dgv7416n71 CNV Gain 21882294
dgv7417n71 CNV Gain 21882294
nsv888845 CNV Gain 21882294
dgv23n31 CNV Duplication 19718026
nsv499529 CNV Loss 21111241
nsv433392 CNV Gain 18776910
nsv436086 CNV Insertion 17901297
nsv436552 CNV Deletion 17901297
dgv7418n71 CNV Gain 21882294
esv2734946 CNV Deletion 23290073
nsv888865 CNV Loss 21882294
dgv7419n71 CNV Loss 21882294
dgv7420n71 CNV Gain 21882294
esv7079 CNV Loss 19470904
nsv888868 CNV Loss 21882294
dgv7421n71 CNV Gain+Loss 21882294
nsv888872 CNV Gain+Loss 21882294
nsv469682 CNV Complex 16826518
nsv471643 CNV Gain+Loss 15918152
nsv509219 CNV Insertion 20534489
dgv7422n71 CNV Loss 21882294
dgv7423n71 CNV Loss 21882294
nsv888877 CNV Loss 21882294
nsv888881 CNV Gain+Loss 21882294
dgv7424n71 CNV Gain 21882294
nsv471451 CNV Duplication 19718026
nsv482112 CNV Gain 20164927
dgv7425n71 CNV Loss 21882294
nsv9 CNV Loss 15895083
nsv499135 CNV Loss 21111241
dgv7426n71 CNV Loss 21882294
dgv7427n71 CNV Gain+Loss 21882294
dgv7428n71 CNV Gain+Loss 21882294
nsv888899 CNV Gain+Loss 21882294
dgv7429n71 CNV Loss 21882294
dgv7430n71 CNV Gain+Loss 21882294
dgv7431n71 CNV Loss 21882294
dgv7432n71 CNV Loss 21882294
nsv888907 CNV Gain+Loss 21882294
dgv7433n71 CNV Loss 21882294
nsv888910 CNV Loss 21882294
dgv7434n71 CNV Loss 21882294
nsv888915 CNV Loss 21882294
nsv888917 CNV Gain+Loss 21882294
dgv7435n71 CNV Gain 21882294
nsv888921 CNV Gain 21882294

Variation tolerance for RASA4 Gene

Gene Damage Index Score: 0.41; 9.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASA4 Gene

HapMap Linkage Disequilibrium report
RASA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASA4 Gene

Disorders for RASA4 Gene

Relevant External Links for RASA4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASA4
genes like me logo Genes that share disorders with RASA4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASA4 Gene

Publications for RASA4 Gene

  1. The GAP1 family of GTPase-activating proteins: spatial and temporal regulators of small GTPase signalling. (PMID: 17052212) Yarwood S. … Kupzig S. (Biochem. Soc. Trans. 2006) 23 67
  2. GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. (PMID: 16431904) Kupzig S. … Cullen P.J. (J. Biol. Chem. 2006) 23 67
  3. Decoding Ca2+ signals: a question of timing. (PMID: 16027217) Muallem S. (J. Cell Biol. 2005) 23 67
  4. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. (PMID: 11448776) Lockyer P.J. … Cullen P.J. (Curr. Biol. 2001) 2 67
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67

Products for RASA4 Gene

Sources for RASA4 Gene

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