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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASA3 Gene

protein-coding   GIFtS: 58
GCID: GC13M114747

RAS P21 Protein Activator 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAS P21 Protein Activator 31 2     GTPase Activating Protein III2
Ins P4-Binding Protein2 3     Inositol 1,3,4,5-Tetrakisphosphate-Binding Protein2
GAP1(IP4BP)2 3     Ins(1,3,4,5)P4-Binding Protein2
GAP1IP4BP2     Ras GTPase-Activating Protein 32
GAPIII2     

External Ids:    HGNC: 203311   Entrez Gene: 228212   Ensembl: ENSG000001859897   OMIM: 6051825   UniProtKB: Q146443   

Export aliases for RASA3 gene to outside databases

Previous GC identifers: GC13M110946 GC13M113779 GC13M112665 GC13M113765 GC13M095016


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RASA3 Gene:
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product
stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS
function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive
GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member
is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2.
The two family members have distinct pleckstrin-homology domains, with this particular member having a domain
consistent with its localization to the plasma membrane. (provided by RefSeq, Jul 2008)

GeneCards Summary for RASA3 Gene: 
RASA3 (RAS p21 protein activator 3) is a protein-coding gene. Diseases associated with RASA3 include neurofibromatosis, and neuronitis, and among its related super-pathways are G-protein signaling Rap1A regulation pathway and G-protein signaling Rap1B regulation pathway. GO annotations related to this gene include phospholipid binding and Ras GTPase activator activity. An important paralog of this gene is SYNGAP1.

UniProtKB/Swiss-Prot: RASA3_HUMAN, Q14644
Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high
affinity. Might be a specific IP4 receptor

Gene Wiki entry for RASA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024498.12  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASA3 gene promoter:
         Sp1   ATF-2   FOXO3   Nkx5-1   FOXO3b   FOXO3a   c-Myb   c-Jun   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RASA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

RASA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASA3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M114747:  view genomic region     (about GC identifiers)

Start:
114,747,194 bp from pter      End:
114,898,095 bp from pter
Size:
150,902 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RASA3_HUMAN, Q14644 (See protein sequence)
Recommended Name: Ras GTPase-activating protein 3  
Size: 834 amino acids; 95699 Da
Subcellular location: Cell membrane
Secondary accessions: A6NL15 Q8IUY2

Explore the universe of human proteins at neXtProt for RASA3: NX_Q14644

Explore proteomics data for RASA3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14644

  • RASA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RASA3 Protein Expression
    REFSEQ proteins: NP_031394.2  
    ENSEMBL proteins: 
     ENSP00000335029   ENSP00000374195   ENSP00000439008  

    Human Recombinant Protein Products for RASA3: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RASA3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IBA--
    GO:0031235intrinsic to internal side of plasma membrane IDA10828023

    RASA3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for RASA3 
    Cloud-Clone Corp. CLIAs for RASA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    5/9 InterPro protein domains (see all 9):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR018029 C2_membr_targeting
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q14644

    ProtoNet protein and cluster: Q14644

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: RASA3_HUMAN, Q14644
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain


    RASA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASA3_HUMAN, Q14644
    Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high
    affinity. Might be a specific IP4 receptor

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity TAS7637787
    GO:0005099Ras GTPase activator activity IBA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0015278calcium-release channel activity IDA10828023
         
    RASA3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RASA3:
     High actin ratio cells 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rasa3):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging 

    RASA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rasa3tm1Shiw for RASA3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RASA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RASA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASA3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RASA3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap1A regulation pathway0.88
    2G-protein signaling Rap1B regulation pathway
    G-protein signaling Rap1B regulation pathway1.00
    3G-protein signaling H-RAS regulation pathway
    G-protein signaling H-RAS regulation pathway1.00
    4G-protein signaling Ras family GTPases in kinase cascades (scheme)
    MAPK Cascade0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for RASA3
        G-protein signaling Rap1B regulation pathway
    G-protein signaling Rap1A regulation pathway
    G-protein signaling H-RAS regulation pathway


    3 GeneGo (Thomson Reuters) Pathways for RASA3
        G-protein signaling H-RAS regulation pathway
    G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap1B regulation pathway

    1 BioSystems Pathway for RASA3
        MAPK Cascade



    RASA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/12 Interacting proteins for RASA3 (Q146443 ENSP000003350294) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB2L1P632443, ENSP000003660134I2D: score=2 STRING: ENSP00000366013
    HCKP086313, ENSP000003650124I2D: score=2 STRING: ENSP00000365012
    RAP1AP628343, ENSP000003487864I2D: score=1 STRING: ENSP00000348786
    FESP073323, ENSP000003315044I2D: score=1 STRING: ENSP00000331504
    ETV6P412123I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS7637787
    GO:0032320positive regulation of Ras GTPase activity IBA--
    GO:0035556intracellular signal transduction IEA--
    GO:0046580negative regulation of Ras protein signal transduction IBA--
    GO:0051056regulation of small GTPase mediated signal transduction ----

    RASA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RASA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RASA3

    8 Novoseek inferred chemical compound relationships for RASA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,3,4,5-tetrakisphosphate 89.8 2 9735347 (1)
    inositol 65.8 4 9874690 (1), 11728827 (1), 8910382 (1)
    phosphatidylinositol-3,4,5-trisphosphate 63.8 1 12885767 (1)
    gdp 56.2 2 8909796 (1)
    gtp 50.2 2 8909796 (1)
    phytate 49.8 1 8645140 (1)
    calcium 15.1 6 9874690 (3), 8645140 (1), 10614983 (1)
    tyrosine 0 1 10614983 (1)

    Search CenterWatch for drugs/clinical trials and news about RASA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RASA3 gene: 
    NM_007368.2  

    Unigene Cluster for RASA3:

    RAS p21 protein activator 3
    Hs.593075  [show with all ESTs]
    Unigene Representative Sequence: AK128094
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334062(uc010tkk.2 uc001vui.3 uc001vuj.3 uc010tkl.1)
    ENST00000389544 ENST00000542651(uc010aha.1)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASA3

    Additional mRNA sequence: 

    AK090595.1 AK128094.1 AK289746.1 AK294913.1 AK295861.1 AK308880.1 AK313795.1 BC038456.1 
    BC047242.1 X89399.1 

    14 DOTS entries:

    DT.412782  DT.101983285  DT.99932857  DT.99970044  DT.120783049  DT.97843106  DT.100652273  DT.120783041 
    DT.120783074  DT.40207128  DT.75109080  DT.95159165  DT.91739827  DT.91746986 

    24/129 AceView cDNA sequences (see all 129):

    BI457491 BQ943217 AI684718 BC038456 BU753968 BC047242 BQ073807 BQ215542 
    BM826935 BU854853 BI755317 BX281763 BP376573 BG033385 BM715990 BM855855 
    CF130965 BU739743 BM999607 BM454560 NM_007368 AI002052 BQ940128 AL550095 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RASA3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
    SP1:                    -           -                             -                                                                                         -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c · 25d ^ 26a · 26b ^ 27a · 27b
    SP1:  -     -                             -                                             
    SP2:  -     -                             -                                             
    SP3:                                                                                    
    SP4:        -                             -                                             
    SP5:                                      -                                             


    ECgene alternative splicing isoforms for RASA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASA3 expression in normal human tissues (normalized intensities)      RASA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTATAAC
    RASA3 Expression
    About this image


    RASA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Globus Pallidus
             Septum   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             cd3+ t cells   
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             visceral organ/oral region/upper jaw   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   

    See RASA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASA3

    SOURCE GeneReport for Unigene cluster: Hs.593075
        SABiosciences Custom PCR Arrays for RASA3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RASA3 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasa31 , 5 RAS p21 protein activator 31, 5 87.05(n)1
    94.84(a)1
      8 (6.29 cM)5
    194141  NM_009025.21  NP_033051.21 
     135669505 
    chicken
    (Gallus gallus)
    Aves RASA31 RAS p21 protein activator 3 79.38(n)
    92.09(a)
      418736  NM_001012825.1  NP_001012843.1 
    lizard
    (Anolis carolinensis)
    Reptilia RASA36
    Uncharacterized protein
    91(a)
    1 ↔ 1
    3(106551562-106661947)
    zebrafish
    (Danio rerio)
    Actinopterygii rasa31 RAS p21 protein activator 3 76.59(n)
    83.07(a)
      100318936  XM_002660315.2  XP_002660361.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gap11 GTPase-activating protein 1 52.35(n)
    43.82(a)
      39158  NM_079290.2  NP_524014.2 
    worm
    (Caenorhabditis elegans)
    Secernentea gap-11 Protein GAP-1 41.24(n)
    28.81(a)
      180530  NM_076003.1  NP_508404.1 


    ENSEMBL Gene Tree for RASA3 (if available)
    TreeFam Gene Tree for RASA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASA3 gene
    SYNGAP12  DAB2IP2  RASA42  RASA12  RASAL32  RASA22  RASA4B2  RASAL22  
    RASAL12  
    4 SIMAP similar genes for RASA3 using alignment to 3 protein entries:     RASA3_HUMAN (see all proteins):
    RASA2    RASA4B    RASAL1    RASA4

    RASA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5118 SNPs in RASA3 are shown (see all 5118)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs678645501,2
    C--95113640(+) GAAAC-/AGGGGTC 1 -- int10--------
    rs619720001,2
    C--95162419(+) GACACA/GGTGGT 1 -- int10--------
    rs626481421,2
    C--95162479(+) GACACA/GGTGGC 1 -- int10--------
    rs1834901191,2
    C--95162606(+) AGGTGA/GGTGTA 1 -- int10--------
    rs1116135371,2
    C,F--95162609(+) TGGGTG/TTAGAC 1 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs1867459851,2
    --95162655(+) CACAGC/TGGTGG 1 -- int10--------
    rs764400091,2
    C--95163095(+) AGACAC/GGGTGG 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1417110001,2
    C--95163105(+) GGTGGG/TTGTAG 1 -- int10--------
    rs714372751,2
    C--95163132(+) AGACAT/CGGTGG 1 -- int11Minor allele frequency- C:0.00NA 2
    rs714372761,2
    C--95163234(+) AGACAC/TGGTGG 1 -- int12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for RASA3 (114747194 - 114898095 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/75 variations for RASA3 (see all 75):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658972CNV Deletion23128226
    esv2106399CNV Deletion18987734
    esv1711123CNV Deletion17803354
    esv1443105CNV Deletion17803354
    esv2666523CNV Deletion23128226
    esv1949106CNV Deletion18987734
    dgv3e22CNV Deletion17803354
    esv1184420CNV Deletion17803354
    esv3511CNV Deletion18987735
    esv1593867CNV Deletion17803354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605182    OMIM disorders: --

    2 diseases for RASA3:    About MalaCards
    neurofibromatosis    neuronitis


    RASA3 for disorders           About GeneDecksing


    Export disorders for RASA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASA3 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with RASA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distinct subcellular localisations of the putative inositol 1,3,4,5- tetrakisphosphate receptors GAP1(IP4BP) and GAP1m result from the GAP1(IP4BP) PH domain directing plasma membrane targeting. (PubMed id 9382842)1, 2, 3, 9 Lockyer P.J.... Cullen P.J. (1997)
    2. Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family. (PubMed id 7637787)1, 2, 3 Cullen P.J.... Irvine R.F. (1995)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Analyzing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular Ca2+ homeostasis. (PubMed id 12356770)1, 9 Walker S.A....Cullen P.J. (2002)
    5. Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes. (PubMed id 10828023)1, 9 El-Daher S.S....Authi K.S. (2000)
    6. GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association. (PubMed id 10869341)1, 9 Cozier G.E....Cullen P.J. (2000)
    7. The ability of GAP1IP4BP to function as a Rap1 GTPase -activating protein (GAP) requires its Ras GAP-related domain and an arginine f inger rather than an asparagine thumb. (PubMed id 19433443)1, 9 Kupzig S....Cullen P.J. (2009)
    8. Tissue-specific expression and endogenous subcellular distribution of the inositol 1,3,4,5-tetrakisphosphate-binding proteins GAP1(IP4BP) and GAP1(m). (PubMed id 10049724)1, 9 Lockyer P.J....Cullen P.J. (1999)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22821 HGNC: 20331 AceView: RASA3 Ensembl:ENSG00000185989 euGenes: HUgn22821
    ECgene: RASA3 H-InvDB: RASA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASA3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RASA3 gene:
    Search GeneIP for patents involving RASA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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