Aliases for RASA3 Gene
External Ids for RASA3 Gene
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane. [provided by RefSeq, Jul 2008]
GeneCards Summary for RASA3 Gene
RASA3 (RAS P21 Protein Activator 3) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). GO annotations related to this gene include phospholipid binding. An important paralog of this gene is RASA2.
UniProtKB/Swiss-Prot for RASA3 Gene
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor