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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RASA3 Gene

protein-coding GIFtS: 57
GCID: GC13M114747

RAS p21 protein activator 3

Explore 2 diseases affiliated with
RASA3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAS P21 Protein Activator 3¹ ²		GTPase Activating Protein III²
GAP1IP4BP¹ ²		Inositol 1,3,4,5-Tetrakisphosphate-Binding Protein²
GAPIII¹ ²		Ins(1,3,4,5)P4-Binding Protein²
Ins P4-Binding Protein² ³		Ras GTPase-Activating Protein 3²
GAP1(IP4BP)² ³

External Ids:	HGNC: 20331¹	Entrez Gene: 22821²	Ensembl: ENSG00000185989⁷	OMIM: 605182⁵	UniProtKB: Q14644³

Export aliases for RASA3 gene to outside databases

Previous GC identifers: GC13M110946 GC13M113779 GC13M112665 GC13M113765 GC13M095016

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RASA3:

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product

stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS

function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound

form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol

1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family

members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its

localization to the plasma membrane. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RASA3_HUMAN, Q14644

Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high

affinity. Might be a specific IP4 receptor

Gene Wiki entry for RASA3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024498.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RASA3 gene promoter:
Sp1 ATF-2 FOXO3 Nkx5-1 FOXO3b FOXO3a c-Myb c-Jun Pax-4a RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RASA3 promoter sequence

Search SABiosciences Chromatin IP Primers for RASA3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASA3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

RASA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASA3 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M114747: view genomic region (about GC identifiers)

Start:	114,747,194 bp from pter	End:	114,898,095 bp from pter
Size:	150,902 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RASA3_HUMAN, Q14644 (See protein sequence)

Recommended Name: Ras GTPase-activating protein 3

Size: 834 amino acids; 95699 Da

Subcellular location: Cell membrane

Secondary accessions: A6NL15 Q8IUY2

Explore the universe of human proteins at neXtProt for RASA3: NX_Q14644

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14644

RASA3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_031394.2

ENSEMBL proteins:

ENSP00000335029 ENSP00000374195 ENSP00000439008

Human Recombinant Protein Products:

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	Novus Biologicals RASA3 Proteins Novus Biologicals RASA3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RASA3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IBA	--
GO:0031235	intrinsic to internal side of plasma membrane	IDA	10828023

RASA3 for ontologies About GeneDecksing

RASA3 Antibody Products:

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	Uscn ELISAs and CLIAs for RASA3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RASA3 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR001936 RasGAP

IPR008936 Rho_GTPase_activation_prot

IPR001849 Pleckstrin_homology

IPR018029 C2_membr_targeting

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q14644

ProtoNet protein and cluster: Q14644

4 Blocks protein families:

IPB000008 C2 domain

IPB001562 Tec/Btk domain signature

IPB001849 Pleckstrin-like

IPB001936 Ras GTPase-activating protein

UniProtKB/Swiss-Prot: RASA3_HUMAN, Q14644

Similarity: Contains 1 Btk-type zinc finger

Similarity: Contains 2 C2 domains

Similarity: Contains 1 PH domain

Similarity: Contains 1 Ras-GAP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RASA3_HUMAN, Q14644

Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high

affinity. Might be a specific IP4 receptor

miRNA Products:		OriGene 3'-UTR Clone: RASA3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASA3
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate RASA3:
		hsa-miR-186 hsa-miR-340 hsa-miR-548c-3p hsa-miR-758
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RASA3

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RASA3
		Search LifeMap BioReagents cell lines for RASA3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA3

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	TAS	7637787
GO:0005099	Ras GTPase activator activity	IBA	--
GO:0005543	phospholipid binding	IEA	--
GO:0015278	calcium-release channel activity	IDA	10828023
GO:0046872	metal ion binding	IEA	--

RASA3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for RASA3:

High actin ratio cells

Animal Models:
Mouse knock-out Rasa3^tm1Shiw for RASA3
9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rasa3):

cardiovascular system	cellular	embryogenesis	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	mortality/aging

RASA3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling Rap1A regulation pathway

	G-protein signaling Rap1A regulation pathway	1.00			G-protein signaling_Rap1B regulation pathway	0.21
	G-protein signaling_Rap1A regulation pathway	0.88			G-protein signaling Rap1B regulation pathway	0.21

G-protein signaling K-RAS regulation pathway

G-protein signaling H-RAS regulation pathway

0.27

G-protein signaling_H-RAS regulation pathway

0.27

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

MAPK Cascade

0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for RASA3

	G-protein signaling Rap1B regulation pathway
	G-protein signaling Rap1A regulation pathway
	G-protein signaling H-RAS regulation pathway

3 GeneGo (Thomson Reuters) Pathways for RASA3

	G-protein signaling H-RAS regulation pathway
	G-protein signaling Rap1A regulation pathway
	G-protein signaling Rap1B regulation pathway

1 BioSystems Pathway for RASA3

MAPK Cascade

RASA3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RASA3

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/12 Interacting proteins for RASA3 (Q14644³ ENSP00000335029⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNB2L1	P63244³, ENSP00000366013⁴	I2D: score=2 STRING: ENSP00000366013
HCK	P08631³, ENSP00000365012⁴	I2D: score=2 STRING: ENSP00000365012
RAP1A	P62834³, ENSP00000348786⁴	I2D: score=1 STRING: ENSP00000348786
FES	P07332³, ENSP00000331504⁴	I2D: score=1 STRING: ENSP00000331504
ETV6	P41212³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	7637787
GO:0032320	positive regulation of Ras GTPase activity	IBA	--
GO:0035556	intracellular signal transduction	IEA	--
GO:0043547	positive regulation of GTPase activity	--	--
GO:0046580	negative regulation of Ras protein signal transduction	IBA	--

RASA3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RASA3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RASA3
8 Novoseek chemical compound relationships for RASA3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inositol 1,3,4,5-tetrakisphosphate	89.8	2	9735347 (1)
inositol	65.8	4	9874690 (1), 11728827 (1), 8910382 (1)
phosphatidylinositol-3,4,5-trisphosphate	63.8	1	12885767 (1)
gdp	56.2	2	8909796 (1)
gtp	50.2	2	8909796 (1)
phytate	49.8	1	8645140 (1)
calcium	15.1	6	9874690 (3), 8645140 (1), 10614983 (1)
tyrosine	0	1	10614983 (1)

Search CenterWatch for drugs/clinical trials and news about RASA3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RASA3 gene:

NM_007368.2

Unigene Cluster for RASA3:

RAS p21 protein activator 3

Hs.593075 [show with all ESTs]

Unigene Representative Sequence: AK128094

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000334062(uc010tkk.2 uc001vui.3 uc001vuj.3 uc010tkl.1)

ENST00000389544 ENST00000542651(uc010aha.1)

miRNA Products:		OriGene 3'-UTR Clone: RASA3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASA3
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate RASA3:
		hsa-miR-186 hsa-miR-340 hsa-miR-548c-3p hsa-miR-758
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RASA3 (see all 7) OriGene shRNA RFP: RASA3 OriGene siRNA: RASA3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASA3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASA3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASA3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RASA3 (NM_007368)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASA3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASA3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASA3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASA3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASA3

Additional cDNA sequence:

AK090595.1 AK128094.1 AK289746.1 AK294913.1 AK295861.1 AK308880.1 AK313795.1 BC038456.1

BC047242.1 X89399.1

14 DOTS entries:

DT.412782 DT.101983285 DT.99932857 DT.99970044 DT.120783049 DT.97843106 DT.100652273 DT.120783041

DT.120783074 DT.40207128 DT.75109080 DT.95159165 DT.91739827 DT.91746986

24/129 AceView cDNA sequences (see all 129):

BI457491 BQ943217 AI684718 BU753968 BC038456 BC047242 BQ073807 BQ215542

BM826935 BU854853 BI755317 BX281763 BP376573 BG033385 BM715990 BM855855

CF130965 BU739743 BM999607 NM_007368 BM454560 AI002052 AL550095 BQ940128

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RASA3 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^
SP1:							-				-										-																														-
SP2:
SP3:
SP4:
SP5:

ExUns:	21a	·	21b	^	22	^	23	^	24a	·	24b	^	25a	·	25b	·	25c	·	25d	^	26a	·	26b	^	27a	·	27b
SP1:	-		-										-
SP2:	-		-										-
SP3:
SP4:			-										-
SP5:													-

ECgene alternative splicing isoforms for RASA3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RASA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTTATAAC

About this image

RASA3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RASA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RASA3

SOURCE GeneReport for Unigene cluster: Hs.593075

SABiosciences Custom PCR Arrays for RASA3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASA3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASA3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASA3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RASA3 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RASA3¹	RAS p21 protein activator 3	79.38(n) 92.09(a)		418736 NM_001012825.1 NP_001012843.1
lizard (Anolis carolinensis)	Reptilia	RASA3⁶	--	90(a)	1 ↔ 1	3(106551562-106661854)
zebrafish (Danio rerio)	Actinopterygii	rasa3¹	RAS p21 protein activator 3	76.59(n) 83.07(a)		100318936 XM_002660315.2 XP_002660361.1
fruit fly (Drosophila melanogaster)	Insecta	Gap1¹	GTPase-activating protein 1	52.35(n) 43.82(a)		39158 NM_079290.2 NP_524014.2
worm (Caenorhabditis elegans)	Secernentea	gap-1¹	Protein GAP-1	41.24(n) 28.81(a)		180530 NM_076003.1 NP_508404.1

ENSEMBL Gene Tree for RASA3 (if available)
TreeFam Gene Tree for RASA3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RASA3 gene

SYNGAP1² RASA2² RASA4B² DAB2IP² RASAL2² RASA4² RASA1² RASAL1²

RASAL3²

4 SIMAP similar genes for RASA3 using alignment to 3 protein entries: RASA3_HUMAN (see all proteins):

RASA2 RASA4B RASAL1 RASA4

RASA3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77363170^1,2	F,	--	95024584(+)	`CCACCC/TATCTC`	1	--	int¹		1		NA	120
rs71449049^1,2	C	--	95041025(+)	`CGGACG/ACCACC`	1	--	int¹		1		NA	2
rs34623098^1,2	C,	--	95041171(+)	`CGGACG/ACCACC`	1	--	int¹		3		NA CSA	5
rs61971855^1,2		--	95041207(+)	`TGGACG/ACCACC`	1	--	int¹		1		NA	2
rs9562138^1,2		--	95041710(+)	`GCACCA/GCGTTC`	1	--	int¹		0	--	--	--	--
rs9562140^1,2	C,F,	--	95041721(+)	`CTGACC/TGTGGG`	1	--	int¹		4		NA WA	8
rs9562141^1,2	C	--	95041780(+)	`CTGACC/TGTGGG`	1	--	int¹		2		NA WA	4
rs113032522^1,2	C	--	95041802(+)	`CCCTGC/GGGCCT`	1	--	int¹		2		WA NA	4
rs74986716^1,2	F	--	95063501(+)	`AAAACG/AGCGTC`	1	--	int¹		2		NA	8
rs36168071^1,2	C,	--	95063577(+)	`ATCCT-/GGGGGC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RASA3 (114747194 - 114898095 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 38 variations for RASA3
12 CNVs: 71821 23458 29947 71820 101883 1950 71822 71817 23457 29948 71818 101882
15/26 Indels (see all 26): 76526 45139 87081 43019 66580 71819 45135 25193 25190 45136 25196 87080 25197 76525 25199

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RASA3 for disorders           About GeneDecksing

OMIM gene information: 605182    OMIM disorders: --

2 diseases for RASA3:    About MalaCards

neurofibromatosis neuronitis

Export disorders for RASA3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RASA3 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with RASA3)

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Distinct subcellular localisations of the putative inositol 1,3,4,5- tetrakisphosphate receptors GAP1(IP4BP) and GAP1m result from the GAP1(IP4BP) PH domain directing plasma membrane targeting. (PubMed id 9382842)^{1, 2, 3, 9} Lockyer P.J.... Cullen P.J. (1997)
Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family. (PubMed id 7637787)^{1, 2, 3} Cullen P.J.... Irvine R.F. (1995)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Analyzing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular Ca2+ homeostasis. (PubMed id 12356770)^{1, 9} Walker S.A....Cullen P.J. (2002)
Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes. (PubMed id 10828023)^{1, 9} El-Daher S.S....Authi K.S. (2000)
GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association. (PubMed id 10869341)^{1, 9} Cozier G.E....Cullen P.J. (2000)
The ability of GAP1IP4BP to function as a Rap1 GTPase -activating protein (GAP) requires its Ras GAP-related domain and an arginine f inger rather than an asparagine thumb. (PubMed id 19433443)^{1, 9} Kupzig S....Cullen P.J. (2009)
Tissue-specific expression and endogenous subcellular distribution of the inositol 1,3,4,5-tetrakisphosphate-binding proteins GAP1(IP4BP) and GAP1(m). (PubMed id 10049724)^{1, 9} Lockyer P.J....Cullen P.J. (1999)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 22821	HGNC: 20331	AceView: RASA3	Ensembl:ENSG00000185989	euGenes: HUgn22821
ECgene: RASA3	H-InvDB: RASA3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RASA3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RASA3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RASA3 gene
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Patent Information for RASA3 gene:
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