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Aliases for RASA3 Gene

Aliases for RASA3 Gene

  • RAS P21 Protein Activator 3 2 3
  • Ins P4-Binding Protein 3 4
  • GAP1(IP4BP) 3 4
  • Inositol 1,3,4,5-Tetrakisphosphate-Binding Protein 3
  • Ins(1,3,4,5)P4-Binding Protein 3
  • GTPase Activating Protein III 3
  • GAP1IP4BP 3
  • GAPIII 3

External Ids for RASA3 Gene

Previous GeneCards Identifiers for RASA3 Gene

  • GC13M110946
  • GC13M113779
  • GC13M112665
  • GC13M113765
  • GC13M114747
  • GC13M095016

Summaries for RASA3 Gene

Entrez Gene Summary for RASA3 Gene

  • The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASA3 Gene

RASA3 (RAS P21 Protein Activator 3) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity and calcium-release channel activity. An important paralog of this gene is RASA2.

UniProtKB/Swiss-Prot for RASA3 Gene

  • Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor

Gene Wiki entry for RASA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASA3 Gene

Genomics for RASA3 Gene

Regulatory Elements for RASA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASA3 Gene

Chromosome:
13
Start:
113,977,783 bp from pter
End:
114,132,620 bp from pter
Size:
154,838 bases
Orientation:
Minus strand

Genomic View for RASA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASA3 Gene

Proteins for RASA3 Gene

  • Protein details for RASA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14644-RASA3_HUMAN
    Recommended name:
    Ras GTPase-activating protein 3
    Protein Accession:
    Q14644
    Secondary Accessions:
    • A6NL15
    • F8W6X8
    • Q8IUY2

    Protein attributes for RASA3 Gene

    Size:
    834 amino acids
    Molecular mass:
    95699 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RASA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASA3 Gene

Proteomics data for RASA3 Gene at MOPED

Post-translational modifications for RASA3 Gene

  • Ubiquitination at Lys 641
  • Modification sites at PhosphoSitePlus

Other Protein References for RASA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASA3 Gene

Domains & Families for RASA3 Gene

Suggested Antigen Peptide Sequences for RASA3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14644

UniProtKB/Swiss-Prot:

RASA3_HUMAN :
  • Contains 2 C2 domains.
  • Contains 1 Btk-type zinc finger.
Domain:
  • Contains 2 C2 domains.
  • Contains 1 PH domain.
  • Contains 1 Ras-GAP domain.
Similarity:
  • Contains 1 Btk-type zinc finger.
genes like me logo Genes that share domains with RASA3: view

Function for RASA3 Gene

Molecular function for RASA3 Gene

UniProtKB/Swiss-Prot Function:
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor

Gene Ontology (GO) - Molecular Function for RASA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
GO:0015278 calcium-release channel activity IDA 10828023
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RASA3: view
genes like me logo Genes that share phenotypes with RASA3: view

Animal Models for RASA3 Gene

MGI Knock Outs for RASA3:

miRNA for RASA3 Gene

miRTarBase miRNAs that target RASA3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASA3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RASA3 Gene

Localization for RASA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASA3 Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASA3 Gene COMPARTMENTS Subcellular localization image for RASA3 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for RASA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IDA 10828023
genes like me logo Genes that share ontologies with RASA3: view

Pathways & Interactions for RASA3 Gene

SuperPathways for RASA3 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Immune System
3 Signaling by GPCR
4 Developmental Biology
5 Ras signaling pathway
genes like me logo Genes that share pathways with RASA3: view

Pathways by source for RASA3 Gene

Gene Ontology (GO) - Biological Process for RASA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0007165 signal transduction TAS 7637787
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RASA3: view

No data available for SIGNOR curated interactions for RASA3 Gene

Drugs & Compounds for RASA3 Gene

(4) Drugs for RASA3 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
inositol 1,3,4,5-tetrakisphosphate Experimental Pharma 0
Calcium Nutra 0
Inositol Nutra 65
tyrosine Nutra 547

(4) Additional Compounds for RASA3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
gdp
gtp
Partial agonist, Agonist
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
phytate
genes like me logo Genes that share compounds with RASA3: view

Transcripts for RASA3 Gene

Unigene Clusters for RASA3 Gene

RAS p21 protein activator 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASA3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASA3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:

ExUns: 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c · 25d ^ 26a · 26b ^ 27a · 27b
SP1: - - -
SP2: - - -
SP3:
SP4: - -
SP5: -
SP6:
SP7: - -
SP8:
SP9:

Relevant External Links for RASA3 Gene

GeneLoc Exon Structure for
RASA3
ECgene alternative splicing isoforms for
RASA3

Expression for RASA3 Gene

mRNA expression in normal human tissues for RASA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RASA3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.9) and Platelet (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RASA3 Gene



SOURCE GeneReport for Unigene cluster for RASA3 Gene Hs.593075

genes like me logo Genes that share expression patterns with RASA3: view

Protein tissue co-expression partners for RASA3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RASA3 Gene

Orthologs for RASA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASA3 35
  • 87.45 (n)
  • 93.65 (a)
RASA3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASA3 35
  • 88.13 (n)
  • 94.6 (a)
RASA3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasa3 35
  • 87.05 (n)
  • 94.84 (a)
Rasa3 16
Rasa3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RASA3 35
  • 99.08 (n)
  • 99.88 (a)
RASA3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasa3 35
  • 85.85 (n)
  • 94.48 (a)
oppossum
(Monodelphis domestica)
Mammalia RASA3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASA3 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASA3 35
  • 79.38 (n)
  • 92.09 (a)
RASA3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASA3 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasa3 35
  • 76.63 (n)
  • 88.72 (a)
zebrafish
(Danio rerio)
Actinopterygii rasa3 35
  • 76.67 (n)
  • 83.07 (a)
rasa3 36
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002261 35
  • 55 (n)
  • 46.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gap1 35
  • 52.42 (n)
  • 43.85 (a)
Gap1 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gap-1 35
  • 41.48 (n)
  • 29.03 (a)
gap-1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for RASA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASA3 Gene

ENSEMBL:
Gene Tree for RASA3 (if available)
TreeFam:
Gene Tree for RASA3 (if available)

Paralogs for RASA3 Gene

Paralogs for RASA3 Gene

(4) SIMAP similar genes for RASA3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RASA3: view

Variants for RASA3 Gene

Structural Variations from Database of Genomic Variants (DGV) for RASA3 Gene

Variant ID Type Subtype PubMed ID
nsv826839 CNV Loss 20364138
nsv901094 CNV Gain+Loss 21882294
nsv901095 CNV Gain 21882294
nsv518916 CNV Loss 19592680
nsv471177 CNV Loss 18288195
dgv121n21 CNV Loss 19592680
dgv1807n71 CNV Loss 21882294
dgv1808n71 CNV Loss 21882294
dgv1809n71 CNV Loss 21882294
nsv64982 CNV Loss 16902084
esv1152044 CNV Deletion 17803354
esv2671257 CNV Deletion 23128226
esv3048 CNV Deletion 18987735
esv2666523 CNV Deletion 23128226
nsv901105 CNV Loss 21882294
esv1954876 CNV Deletion 18987734
esv2670849 CNV Deletion 23128226
esv24032 CNV Gain+Loss 19812545
esv2607681 CNV Deletion 19546169
nsv512345 CNV Loss 21212237
esv1711123 CNV Deletion 17803354
esv2106853 CNV Deletion 18987734
esv1443105 CNV Deletion 17803354
esv1142582 CNV Deletion 17803354
dgv3e22 CNV Deletion 17803354
esv1025672 CNV Deletion 17803354
nsv1196 CNV Insertion 18451855
esv3511 CNV Deletion 18987735
nsv64415 CNV Loss 16902084
esv2677949 CNV Deletion 23128226
esv1636109 CNV Deletion 17803354
nsv901106 CNV Gain 21882294
esv2168491 CNV Deletion 18987734
esv1949106 CNV Deletion 18987734
esv24269 CNV Loss 19812545
esv1716683 CNV Deletion 17803354
esv1482832 CNV Deletion 17803354
esv22933 CNV Gain 19812545
esv6719 CNV Loss 19470904
nsv438258 CNV Loss 16468122
esv2338969 CNV Deletion 18987734
esv995537 CNV Deletion 20482838
esv2106399 CNV Deletion 18987734
esv27815 CNV Loss 19812545
nsv901107 CNV Loss 21882294
esv1462897 CNV Insertion 17803354
esv1621942 CNV Insertion 17803354
esv1010513 CNV Deletion 20482838
esv24173 CNV Gain+Loss 19812545
nsv512346 CNV Loss 21212237
nsv821504 CNV Deletion 20802225
esv1593867 CNV Deletion 17803354
esv1789942 CNV Deletion 17803354
nsv901108 CNV Gain+Loss 21882294
dgv1810n71 CNV Loss 21882294
nsv64635 CNV Loss 16902084
esv29166 CNV Loss 19812545
esv997265 CNV Deletion 20482838
esv1576861 CNV Deletion 17803354
nsv64423 CNV Loss 16902084
nsv524968 CNV Loss 19592680
esv1009187 CNV Loss 20482838
esv1184420 CNV Deletion 17803354
nsv901111 CNV Loss 21882294
esv272603 CNV Insertion 20981092
esv271462 CNV Insertion 20981092
esv2098450 CNV Deletion 18987734
esv2662327 CNV Deletion 23128226
esv2664744 CNV Deletion 23128226
esv2674574 CNV Deletion 23128226
nsv901112 CNV Loss 21882294
esv2544651 CNV Deletion 19546169
esv1066402 CNV Deletion 17803354
esv2658972 CNV Deletion 23128226
esv2678799 CNV Deletion 23128226

Variation tolerance for RASA3 Gene

Residual Variation Intolerance Score: 3.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASA3 Gene

HapMap Linkage Disequilibrium report
RASA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RASA3 Gene

Disorders for RASA3 Gene

Relevant External Links for RASA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASA3
genes like me logo Genes that share disorders with RASA3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASA3 Gene

Publications for RASA3 Gene

  1. Distinct subcellular localisations of the putative inositol 1,3,4,5- tetrakisphosphate receptors GAP1(IP4BP) and GAP1m result from the GAP1(IP4BP) PH domain directing plasma membrane targeting. (PMID: 9382842) Lockyer P.J. … Cullen P.J. (Curr. Biol. 1997) 2 23 67
  2. The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb. (PMID: 19433443) Kupzig S. … Cullen P.J. (Mol. Cell. Biol. 2009) 23 67
  3. GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. (PMID: 16431904) Kupzig S. … Cullen P.J. (J. Biol. Chem. 2006) 23 67
  4. Studying the spatial and temporal regulation of Ras GTPase-activating proteins. (PMID: 16757315) Kupzig S. … Cullen P.J. (Meth. Enzymol. 2006) 23 67
  5. The GAP1 family of GTPase-activating proteins: spatial and temporal regulators of small GTPase signalling. (PMID: 17052212) Yarwood S. … Kupzig S. (Biochem. Soc. Trans. 2006) 23 67

Products for RASA3 Gene

Sources for RASA3 Gene

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