Aliases for RASA2 Gene
External Ids for RASA2 Gene
Previous GeneCards Identifiers for RASA2 Gene
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for RASA2 Gene
RASA2 (RAS P21 Protein Activator 2) is a Protein Coding gene. Diseases associated with RASA2 include Neurofibromatosis and Cranial Nerve Malignant Neoplasm. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Development Angiotensin activation of ERK. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RASAL1.
UniProtKB/Swiss-Prot for RASA2 Gene
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).