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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASA2 Gene

protein-coding   GIFtS: 56
GCID: GC03P141205

RAS P21 Protein Activator 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAS P21 Protein Activator 21 2     Ras GTPase-Activating Protein 22
GAP1M2 3 5     GAP1m3
GTPase-Activating Protein 1m2 3     RASGAP3
GTPase-Activating Protein Of RAS2     

External Ids:    HGNC: 98721   Entrez Gene: 59222   Ensembl: ENSG000001559037   OMIM: 6015895   UniProtKB: Q152833   

Export aliases for RASA2 gene to outside databases

Previous GC identifers: GC03P138122 GC03P142034 GC03P142487 GC03P142526 GC03P142688 GC03P138580


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RASA2 Gene:
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product
stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS
function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive
GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular
family member has a perinuclear localization and is an inositol 1,3,4,5-tetrakisphosphate-binding protein; a
compound suggested to function as a second messenger. (provided by RefSeq, Jul 2008)

GeneCards Summary for RASA2 Gene: 
RASA2 (RAS p21 protein activator 2) is a protein-coding gene. Diseases associated with RASA2 include juvenile myelomonocytic leukemia, and neurofibromatosis, and among its related super-pathways are MAPK signaling pathway and G-protein signaling M-RAS regulation pathway. GO annotations related to this gene include phospholipid binding and Ras GTPase activator activity. An important paralog of this gene is SYNGAP1.

UniProtKB/Swiss-Prot: RASA2_HUMAN, Q15283
Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASA2 gene promoter:
         ER-alpha   RFX1   AML1a   Ik-3   Tal-1beta   LCR-F1   HNF-1A   HNF-1   Sox9   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RASA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22-q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q22-q23

RASA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASA2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P141205:  view genomic region     (about GC identifiers)

Start:
141,205,889 bp from pter      End:
141,334,184 bp from pter
Size:
128,296 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RASA2_HUMAN, Q15283 (See protein sequence)
Recommended Name: Ras GTPase-activating protein 2  
Size: 850 amino acids; 96614 Da
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region
Secondary accessions: A8K7K1 G3V0F9 O00695 Q15284 Q92594 Q99577 Q9UEQ2
Alternative splicing: 2 isoforms:  Q15283-1   Q15283-2   

Explore the universe of human proteins at neXtProt for RASA2: NX_Q15283

Explore proteomics data for RASA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15283

  • RASA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RASA2 Protein Expression
    REFSEQ proteins: NP_006497.2  
    ENSEMBL proteins: 
     ENSP00000424293   ENSP00000286364   ENSP00000391677  

    Human Recombinant Protein Products for RASA2: 
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    Cloud-Clone Corp. Proteins for RASA2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IBA--
    GO:0031235intrinsic to internal side of plasma membrane IBA--
    GO:0043231intracellular membrane-bounded organelle IDA--
    GO:0048471perinuclear region of cytoplasm IEA--

    RASA2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for RASA2 
    Cloud-Clone Corp. CLIAs for RASA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    5/9 InterPro protein domains (see all 9):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR018029 C2_membr_targeting
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q15283

    ProtoNet protein and cluster: Q15283

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: RASA2_HUMAN, Q15283
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain


    RASA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASA2_HUMAN, Q15283
    Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4)

         Genatlas biochemistry entry for RASA2:
    RAS-p21 GTPase-activating protein,100 kDa,isoform placenta specific

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0005099Ras GTPase activator activity IBA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0046872metal ion binding IEA--
         
    RASA2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RASA2:
     Increased mitotic index 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RASA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RASA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASA2 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate RASA2:
    hsa-miR-145
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RASA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2G-protein signaling TC21 regulation pathway
    G-protein signaling M-RAS regulation pathway0.71
    G-protein signaling TC21 regulation pathway0.71
    3Development Angiotensin activation of ERK
    Development G-Proteins mediated regulation MARK-ERK signaling0.66
    4G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-12 signaling pathway0.40
    5Viral carcinogenesis
    Viral carcinogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for RASA2
        G-protein signaling M-RAS regulation pathway
    G-protein signaling TC21 regulation pathway
    Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling G-Protein alpha-12 signaling pathway


    4 GeneGo (Thomson Reuters) Pathways for RASA2
        G-protein signaling TC21 regulation pathway
    G-protein signaling M-RAS regulation pathway
    Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling G-Protein alpha-12 signaling pathway

    1 BioSystems Pathway for RASA2
        MAPK signaling pathway


    2         Kegg Pathways  (Kegg details for RASA2):
        MAPK signaling pathway
    Viral carcinogenesis


    RASA2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for RASA2 (Q152833 ENSP000002863644) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNA12Q031133, ENSP000002753644I2D: score=2 STRING: ENSP00000275364
    HRASENSP000003098454STRING: ENSP00000309845
    RRASENSP000002467924STRING: ENSP00000246792
    GNG12ENSP000003600214STRING: ENSP00000360021
    MRASENSP000002891044STRING: ENSP00000289104
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8699317
    GO:0032320positive regulation of Ras GTPase activity IBA--
    GO:0035556intracellular signal transduction IEA--
    GO:0046580negative regulation of Ras protein signal transduction IBA--
    GO:0051056regulation of small GTPase mediated signal transduction ----

    RASA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RASA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RASA2

    10/13 Novoseek inferred chemical compound relationships for RASA2 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 65.4 9 11389730 (1), 8621595 (1), 17094109 (1), 9468490 (1) (see all 7)
    inositol 1,3,4,5-tetrakisphosphate 65.2 2 9735347 (1), 10861245 (1)
    phosphatidylinositol 63.2 19 7692230 (2), 10463951 (2), 8164650 (1), 7743180 (1) (see all 16)
    phosphotyrosine 61.5 2 8890167 (1), 7961710 (1)
    tyrosine 60.4 29 8164650 (1), 8524223 (1), 10448070 (1), 10688886 (1) (see all 24)
    gdp 59.3 1 11389730 (1)
    inositol 34.8 2 10049724 (1), 11728827 (1)
    guanine 24.9 1 7622571 (1)
    sphingosine 17.9 4 10463951 (2), 12776187 (1)
    arachidonic acid 0 1 8576154 (1)

    Search CenterWatch for drugs/clinical trials and news about RASA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RASA2 gene: 
    NM_006506.2  

    Unigene Cluster for RASA2:

    RAS p21 protein activator 2
    Hs.655941  [show with all ESTs]
    Unigene Representative Sequence: AK292016
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515549 ENST00000286364(uc003etz.1) ENST00000505833 ENST00000509118
    ENST00000509032 ENST00000506365 ENST00000452898(uc010huq.1 uc003eua.1 uc011bnc.1)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate RASA2:
    hsa-miR-145
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    Additional mRNA sequence: 

    AB209161.1 AF115573.1 AK292016.1 AK301015.1 D78155.1 D82880.1 

    8 DOTS entries:

    DT.40254910  DT.40206898  DT.95353096  DT.40125189  DT.91792973  DT.100701847  DT.102839041  DT.91711273 

    24/115 AceView cDNA sequences (see all 115):

    BM543307 CR620532 BQ268939 D82880 CA431012 AL700400 AF115573 CK429938 
    AK025305 R79815 AI683022 AI354628 NM_006506 AW827184 BX104990 BX433019 
    BI856082 AI266002 BX485498 AI801901 BI829624 AA737535 AA384832 BM313623 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RASA2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                            -     -                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 26a · 26b
    SP1:            
    SP2:            
    SP3:            


    ECgene alternative splicing isoforms for RASA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RASA2 Expression
    About this image


    See RASA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASA2

    SOURCE GeneReport for Unigene cluster: Hs.655941
        SABiosciences Custom PCR Arrays for RASA2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RASA2 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasa21 , 5 RAS p21 protein activator 21, 5 88.08(n)1
    89.49(a)1
      9 (50.66 cM)5
    1147131  NM_053268.21  NP_444498.21 
     965393005 
    chicken
    (Gallus gallus)
    Aves RASA21 RAS p21 protein activator 2 79.63(n)
    83.37(a)
      424782  NM_001012929.1  NP_001012947.1 
    lizard
    (Anolis carolinensis)
    Reptilia RASA26
    Uncharacterized protein
    82(a)
    1 ↔ 1
    3(22228762-22274452)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.74132 Xenopus laevis transcribed sequence with weak similarity more 76.29(n)    48040272 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01024201.16
    Uncharacterized protein
    68(a)
    1 ↔ 1
    18(39390278-39529481)
    fruit fly
    (Drosophila melanogaster)
    Insecta Gap13 RAS protein signal transduction RAS
    GTPase activator
    34(a)     --


    ENSEMBL Gene Tree for RASA2 (if available)
    TreeFam Gene Tree for RASA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASA2 gene
    SYNGAP12  DAB2IP2  RASA42  RASA12  RASAL32  RASA4B2  RASAL22  RASA32  
    RASAL12  
    3 SIMAP similar genes for RASA2 using alignment to 2 protein entries:     RASA2_HUMAN (see all proteins):
    RASA3    RASA4    RASA4B

    RASA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2316 SNPs in RASA2 are shown (see all 2316)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445650841,2
    Cuntested1244154152(+) GTAATC/TGAGGA 2 I syn10--------
    rs117167761,2
    C,F,A,H--138578978(+) CTGACG/ACGGAT 1 -- us2k18Minor allele frequency- A:0.21NA WA 250
    rs1918799801,2
    --138579077(+) GGTGGC/TGCGCA 1 -- us2k10--------
    rs117168321,2
    C,H--138579243(+) aaagaG/AaaGAA 1 -- us2k1 trp31Minor allele frequency- A:0.00NA 2
    rs1428920681,2
    --138579336(+) GGATGC/TCTTTA 1 -- us2k10--------
    rs1461215821,2
    --138579349(+) AATAAC/GGGGGA 1 -- us2k10--------
    rs622820061,2
    C--138579402(+) TTTAAC/TAAGGG 1 -- us2k14Minor allele frequency- T:0.29NA EA 244
    rs1150580991,2
    C,F--138579734(+) CATTCT/GCTGGG 1 -- us2k12Minor allele frequency- G:0.02WA NA 238
    rs2020701011,2
    C--138579824(+) CTCTG-/CCTTTT 1 -- us2k10--------
    rs38066451,2
    C--138579825(+) CTGGCA/CTTTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RASA2 (141205889 - 141334184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RASA2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676781CNV Deletion23128226
    esv1084666CNV Deletion17803354
    esv271649CNV Insertion20981092
    esv270683CNV Insertion20981092
    nsv237170CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601589    OMIM disorders: --

    15 diseases for RASA2:    About MalaCards
    juvenile myelomonocytic leukemia    neurofibromatosis    choriocarcinoma    neurofibroma
    spastic paraparesis    tropical spastic paraparesis    prion disease    spasticity
    acute myeloid leukemia    prostate cancer    myeloid leukemia    prostatitis
    leukemia    lung cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RASA2:
    Kuru encephalopathy

    RASA2 for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for RASA2 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 1 77 6 17234759 (1), 1749934 (1), 8341688 (1), 10706287 (1) (see all 6)
    neurofibromatosis 52 1 1883874 (1)
    trophoblastic tumor 51 2 9689648 (1), 7747802 (1)
    hydatidiform mole 41.4 1 9250705 (1)
    multiple tumors 38.6 1 9689648 (1)
    genetic disorder 26.4 1 8341688 (1)
    choriocarcinoma 19.2 1 10712588 (1)
    tumors 13.2 14 9689648 (4), 12895371 (1), 18073375 (1), 17640920 (1) (see all 8)
    prostate cancer 11.6 8 9689648 (3), 18073375 (1), 20154697 (1)
    leukemia 0 2 8954928 (1), 8563750 (1)


    Export disorders for RASA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASA2 gene, integrated from 9 sources (see all 154):
    (articles sorted by number of sources associating them with RASA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distinct subcellular localisations of the putative inositol 1,3,4,5- tetrakisphosphate receptors GAP1(IP4BP) and GAP1m result from the GAP1(IP4BP) PH domain directing plasma membrane targeting. (PubMed id 9382842)1, 2, 9 Lockyer P.J.... Cullen P.J. (1997)
    2. [Heterogeneity of GTPase-activating proteins for Ras in the regulation of Ras signal transduction pathway] (PubMed id 8699317)1, 3, 9 Hattori S. and Baba H. (1996)
    3. cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M), a GTPase-activating protein of Ras. (PubMed id 8812506)1, 2, 9 Li S.... Hattori S. (1996)
    4. Human rasGTPase-activating protein (human counterpart of GAP1m): sequence of the cDNA, primary structure of the protein, production and chromosomal localization. (PubMed id 8917095)1, 2 Kobayashi M....Iwashita S. (1996)
    5. The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain. (PubMed id 9796816)1, 9 Jiang Y....Huang X.Y. (1998)
    6. Seventy-five genetic loci influencing the human red bl ood cell. (PubMed id 23222517)1 van der Harst P....Chambers J.C. (2012)
    7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    8. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (PubMed id 22210626)1 Mead S....Collinge J. (2012)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5922 HGNC: 9872 AceView: RASA2 Ensembl:ENSG00000155903 euGenes: HUgn5922
    ECgene: RASA2 Kegg: 5922 H-InvDB: RASA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RASA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RASA2 gene:
    Search GeneIP for patents involving RASA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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