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Aliases for RASA2 Gene

Aliases for RASA2 Gene

  • RAS P21 Protein Activator 2 2 3
  • GAP1M 3 4 6
  • GTPase-Activating Protein 1m 3 4
  • GTPase-Activating Protein Of RAS 3
  • Ras GTPase-Activating Protein 2 3
  • RASGAP 4

External Ids for RASA2 Gene

Previous GeneCards Identifiers for RASA2 Gene

  • GC03P138122
  • GC03P142034
  • GC03P142487
  • GC03P142526
  • GC03P142688
  • GC03P141205
  • GC03P138580

Summaries for RASA2 Gene

Entrez Gene Summary for RASA2 Gene

  • The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for RASA2 Gene

RASA2 (RAS P21 Protein Activator 2) is a Protein Coding gene. Diseases associated with RASA2 include noonan syndrome 1 and kuru. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is RASAL1.

UniProtKB/Swiss-Prot for RASA2 Gene

  • Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4)

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASA2 Gene

Genomics for RASA2 Gene

Regulatory Elements for RASA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RASA2 Gene

Start:
141,487,047 bp from pter
End:
141,615,344 bp from pter
Size:
128,298 bases
Orientation:
Plus strand

Genomic View for RASA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RASA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASA2 Gene

Proteins for RASA2 Gene

  • Protein details for RASA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15283-RASA2_HUMAN
    Recommended name:
    Ras GTPase-activating protein 2
    Protein Accession:
    Q15283
    Secondary Accessions:
    • A8K7K1
    • G3V0F9
    • O00695
    • Q15284
    • Q92594
    • Q99577
    • Q9UEQ2

    Protein attributes for RASA2 Gene

    Size:
    850 amino acids
    Molecular mass:
    96614 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RASA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASA2 Gene

Proteomics data for RASA2 Gene at MOPED

Post-translational modifications for RASA2 Gene

  • Ubiquitination at Lys419
  • Modification sites at PhosphoSitePlus

Other Protein References for RASA2 Gene

No data available for DME Specific Peptides for RASA2 Gene

Domains for RASA2 Gene

Gene Families for RASA2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Suggested Antigen Peptide Sequences for RASA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15283

UniProtKB/Swiss-Prot:

RASA2_HUMAN :
  • Q15283
Domain:
  • Contains 2 C2 domains.
  • Contains 1 PH domain.
  • Contains 1 Ras-GAP domain.
Similarity:
  • Contains 1 Btk-type zinc finger.
genes like me logo Genes that share domains with RASA2: view

Function for RASA2 Gene

Molecular function for RASA2 Gene

GENATLAS Biochemistry: RAS-p21 GTPase-activating protein,100 kDa,isoform placenta specific
UniProtKB/Swiss-Prot Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4)

Gene Ontology (GO) - Molecular Function for RASA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RASA2: view

Phenotypes for RASA2 Gene

GenomeRNAi human phenotypes for RASA2:
genes like me logo Genes that share phenotypes with RASA2: view

Animal Model Products

CRISPR Products

miRNA for RASA2 Gene

miRTarBase miRNAs that target RASA2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RASA2 Gene

Localization for RASA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASA2 Gene

Cytoplasm. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASA2 Gene COMPARTMENTS Subcellular localization image for RASA2 gene
Compartment Confidence
cytosol 3
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RASA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with RASA2: view

Pathways for RASA2 Gene

genes like me logo Genes that share pathways with RASA2: view

Gene Ontology (GO) - Biological Process for RASA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8699317
GO:0035556 intracellular signal transduction IEA --
GO:0043547 positive regulation of GTPase activity TAS 8812506
GO:0046580 negative regulation of Ras protein signal transduction IBA --
genes like me logo Genes that share ontologies with RASA2: view

Compounds for RASA2 Gene

(13) Novoseek inferred chemical compound relationships for RASA2 Gene

Compound -log(P) Hits PubMed IDs
gtp 65.4 7
inositol 1,3,4,5-tetrakisphosphate 65.2 2
phosphatidylinositol 63.2 18
phosphotyrosine 61.5 2
tyrosine 60.4 24
genes like me logo Genes that share compounds with RASA2: view

Transcripts for RASA2 Gene

Unigene Clusters for RASA2 Gene

RAS p21 protein activator 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RASA2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RASA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - -
SP2:
SP3:

ExUns: 26a · 26b
SP1:
SP2:
SP3:

Relevant External Links for RASA2 Gene

GeneLoc Exon Structure for
RASA2
ECgene alternative splicing isoforms for
RASA2

Expression for RASA2 Gene

mRNA expression in normal human tissues for RASA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RASA2 Gene

SOURCE GeneReport for Unigene cluster for RASA2 Gene Hs.655941

genes like me logo Genes that share expressions with RASA2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RASA2 Gene

Orthologs for RASA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASA2 35
  • 99.72 (n)
  • 99.76 (a)
RASA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASA2 35
  • 94.87 (n)
  • 97.36 (a)
RASA2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASA2 35
  • 95.08 (n)
  • 96.7 (a)
RASA2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rasa2 35
  • 88.43 (n)
  • 89.81 (a)
Rasa2 16
Rasa2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASA2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASA2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasa2 35
  • 88.39 (n)
  • 90.05 (a)
chicken
(Gallus gallus)
Aves RASA2 35
  • 78.97 (n)
  • 82.52 (a)
RASA2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASA2 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7413 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rasa2 35
  • 72.59 (n)
  • 76.76 (a)
Str.3861 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01024201.1 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Gap1 36
  • 28 (a)
OneToMany
Gap1 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea gap-1 36
  • 25 (a)
OneToMany
gap-1 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for RASA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASA2 Gene

ENSEMBL:
Gene Tree for RASA2 (if available)
TreeFam:
Gene Tree for RASA2 (if available)

Paralogs for RASA2 Gene

Paralogs for RASA2 Gene

Selected SIMAP similar genes for RASA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASA2: view

Variants for RASA2 Gene

Sequence variations from dbSNP and Humsavar for RASA2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1709 -- 141,612,723(-) TTGGA(A/G)TTTTC downstream-variant-500B, utr-variant-3-prime
rs15759 -- 141,614,815(+) CCAAA(G/T)AAACT utr-variant-3-prime
rs188414 -- 141,615,778(+) ccttg(G/T)gatct downstream-variant-500B
rs190906 -- 141,615,717(+) tttgt(A/T)ttttt downstream-variant-500B
rs192686 -- 141,615,621(+) cactg(A/C/G)aacct downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RASA2 Gene

Variant ID Type Subtype PubMed ID
esv2676781 CNV Deletion 23128226
esv271649 CNV Insertion 20981092
esv270683 CNV Insertion 20981092
esv1084666 CNV Deletion 17803354
nsv237170 CNV Loss 16902084

Relevant External Links for RASA2 Gene

HapMap Linkage Disequilibrium report
RASA2
Human Gene Mutation Database (HGMD)
RASA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASA2 Gene

Disorders for RASA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for RASA2 Gene including...

Search for RASA2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RASA2 Gene

(12) Novoseek inferred disease relationships for RASA2 Gene

Disease -log(P) Hits PubMed IDs
neurofibromatosis type 1 77 6
neurofibromatosis 52 1
trophoblastic tumor 51 2
hydatidiform mole 41.4 1
multiple tumors 38.6 1
genes like me logo Genes that share disorders with RASA2: view

No data available for UniProtKB/Swiss-Prot for RASA2 Gene

Publications for RASA2 Gene

  1. cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M), a GTPase-activating protein of Ras. (PMID: 8812506) Li S. … Hattori S. (Genomics 1996) 3 4 23
  2. Distinct subcellular localisations of the putative inositol 1,3,4,5- tetrakisphosphate receptors GAP1(IP4BP) and GAP1m result from the GAP1(IP4BP) PH domain directing plasma membrane targeting. (PMID: 9382842) Lockyer P.J. … Cullen P.J. (Curr. Biol. 1997) 3 4 23
  3. [Heterogeneity of GTPase-activating proteins for Ras in the regulation of Ras signal transduction pathway]. (PMID: 8699317) Hattori S. … Baba H. (Yakugaku Zasshi 1996) 2 3 23
  4. Human rasGTPase-activating protein (human counterpart of GAP1m): sequence of the cDNA, primary structure of the protein, production and chromosomal localization. (PMID: 8917095) Kobayashi M. … Iwashita S. (Gene 1996) 3 4
  5. The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain. (PMID: 9796816) Jiang Y. … Huang X.Y. (Nature 1998) 3 23

Products for RASA2 Gene

Sources for RASA2 Gene

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