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RASA2 Gene

protein-coding   GIFtS: 58
GCID: GC03P141205

RAS P21 Protein Activator 2

  See RASA2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAS P21 Protein Activator 21 2     Ras GTPase-Activating Protein 22
GAP1M2 3 5     GAP1m3
GTPase-Activating Protein 1m2 3     RASGAP3
GTPase-Activating Protein Of RAS2     

External Ids:    HGNC: 98721   Entrez Gene: 59222   Ensembl: ENSG000001559037   OMIM: 6015895   UniProtKB: Q152833   

Export aliases for RASA2 gene to outside databases

Previous GC identifers: GC03P138122 GC03P142034 GC03P142487 GC03P142526 GC03P142688 GC03P138580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RASA2 Gene:
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product
stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS
function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive
GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular
family member has a perinuclear localization and is an inositol 1,3,4,5-tetrakisphosphate-binding protein; a
compound suggested to function as a second messenger. (provided by RefSeq, Jul 2008)

GeneCards Summary for RASA2 Gene:
RASA2 (RAS p21 protein activator 2) is a protein-coding gene. Diseases associated with RASA2 include kuru, and neurofibromatosis. GO annotations related to this gene include phospholipid binding and Ras GTPase activator activity. An important paralog of this gene is SYNGAP1.

UniProtKB/Swiss-Prot: RASA2_HUMAN, Q15283
Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASA2 gene promoter:
         ER-alpha   RFX1   AML1a   Ik-3   Tal-1beta   LCR-F1   HNF-1A   HNF-1   Sox9   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRASA2 promoter sequence
   Search Chromatin IP Primers for RASA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22-q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q22-q23

RASA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASA2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P141205:  view genomic region     (about GC identifiers)

Start:
141,205,889 bp from pter      End:
141,334,184 bp from pter
Size:
128,296 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RASA2_HUMAN, Q15283 (See protein sequence)
Recommended Name: Ras GTPase-activating protein 2  
Size: 850 amino acids; 96614 Da
Secondary accessions: A8K7K1 G3V0F9 O00695 Q15284 Q92594 Q99577 Q9UEQ2
Alternative splicing: 2 isoforms:  Q15283-1   Q15283-2   

Explore the universe of human proteins at neXtProt for RASA2: NX_Q15283

Explore proteomics data for RASA2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys419
  • Modification sites at PhosphoSitePlus

  • See RASA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006497.2  
    ENSEMBL proteins: 
     ENSP00000424293   ENSP00000286364   ENSP00000391677  

    RASA2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    Selected InterPro protein domains (see all 7):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR023152 RasGAP_CS

    Graphical View of Domain Structure for InterPro Entry Q15283

    ProtoNet protein and cluster: Q15283

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: RASA2_HUMAN, Q15283
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain


    Find genes that share domains with RASA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASA2_HUMAN, Q15283
    Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4)

         Genatlas biochemistry entry for RASA2:
    RAS-p21 GTPase-activating protein,100 kDa,isoform placenta specific

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0005099Ras GTPase activator activity IBA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with RASA2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RASA2:
     Increased mitotic index 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASA2
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    miRNA
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    miRTarBase miRNAs that target RASA2:
    hsa-mir-335-5p (MIRT018937)

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    1 qRT-PCR Assays for microRNA that regulate RASA2:
    hsa-miR-145
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RASA2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RASA2_HUMAN, Q15283: Cytoplasm. Cytoplasm, perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IBA--
    GO:0031235intrinsic component of the cytoplasmic side of the plasma membrane IBA--
    GO:0043231intracellular membrane-bounded organelle ----
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with RASA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RASA2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2G protein signaling TC21 regulation pathway
    G protein signaling TC21 regulation pathway0.71
    G protein signaling M RAS regulation pathway0.71
    3Development Angiotensin activation of ERK
    Development G Proteins mediated regulation MARK ERK signaling0.66
    4G protein signaling Regulation of p38 and JNK signaling mediated by G proteins
    G protein signaling G Protein alpha 12 signaling pathway0.40
    5Ras signaling pathway
    Ras signaling pathway0.36


    Find genes that share SuperPaths with RASA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 GeneGo (Thomson Reuters) Pathways for RASA2
        G-protein signaling TC21 regulation pathway
    G-protein signaling M-RAS regulation pathway
    Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling G-Protein alpha-12 signaling pathway

    1 BioSystems Pathway for RASA2
        MAPK signaling pathway


    3 Kegg Pathways  (Kegg details for RASA2):
        MAPK signaling pathway
    Ras signaling pathway
    Viral carcinogenesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RASA2
    Interactions:

        Search GeneGlobe Interaction Network for RASA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RASA2 (Q152833 ENSP000002863644) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNA12Q031133, ENSP000002753644I2D: score=2 STRING: ENSP00000275364
    GNG12ENSP000003600214STRING: ENSP00000360021
    MRASENSP000002891044STRING: ENSP00000289104
    ETV6ENSP000002664274STRING: ENSP00000266427
    GPRC5BENSP000003005714STRING: ENSP00000300571
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8699317
    GO:0032320positive regulation of Ras GTPase activity IBA--
    GO:0035556intracellular signal transduction IEA--
    GO:0046580negative regulation of Ras protein signal transduction IBA--
    GO:0051056regulation of small GTPase mediated signal transduction ----

    Find genes that share ontologies with RASA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASA2

    Selected Novoseek inferred chemical compound relationships for RASA2 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 65.4 9 11389730 (1), 8621595 (1), 17094109 (1), 9468490 (1) (see all 7)
    inositol 1,3,4,5-tetrakisphosphate 65.2 2 9735347 (1), 10861245 (1)
    phosphatidylinositol 63.2 19 7692230 (2), 10463951 (2), 8164650 (1), 7743180 (1) (see all 16)
    phosphotyrosine 61.5 2 8890167 (1), 7961710 (1)
    tyrosine 60.4 29 8164650 (1), 8524223 (1), 10448070 (1), 10688886 (1) (see all 24)
    gdp 59.3 1 11389730 (1)
    inositol 34.8 2 10049724 (1), 11728827 (1)
    guanine 24.9 1 7622571 (1)
    sphingosine 17.9 4 10463951 (2), 12776187 (1)
    arachidonic acid 0 1 8576154 (1)



    Find genes that share compounds with RASA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RASA2 gene: 
    NM_006506.2  

    Unigene Cluster for RASA2:

    RAS p21 protein activator 2
    Hs.655941  [show with all ESTs]
    Unigene Representative Sequence: AK292016
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515549 ENST00000286364(uc003etz.1) ENST00000505833 ENST00000509118
    ENST00000509032 ENST00000506365 ENST00000452898(uc010huq.1 uc003eua.1 uc011bnc.1)

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    hsa-miR-145
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AB209161.1 AF115573.1 AK292016.1 AK301015.1 D78155.1 D82880.1 

    8 DOTS entries:

    DT.40254910  DT.40206898  DT.95353096  DT.40125189  DT.91792973  DT.100701847  DT.102839041  DT.91711273 

    Selected AceView cDNA sequences (see all 115):

    R79815 BM543307 CK429938 AK025305 AF115573 CR620532 AL700400 AI683022 
    AW827184 CA431012 BQ268939 NM_006506 AI354628 D82880 BM968286 AI888503 
    AV709788 BX485498 CK905128 AA737535 BI829624 BX104990 BF793566 BU622516 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RASA2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                            -     -                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 26a · 26b
    SP1:            
    SP2:            
    SP3:            


    ECgene alternative splicing isoforms for RASA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RASA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RASA2 Expression
    About this image


    RASA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Brain (Nervous System)
             Lateral Ventricle
    RASA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655941
        Custom PCR Arrays for RASA2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RASA2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasa21 , 5 RAS p21 protein activator 21, 5 88.43(n)1
    89.81(a)1
      9 (50.66 cM)5
    1147131  NM_053268.21  NP_444498.21 
     965393005 
    chicken
    (Gallus gallus)
    Aves RASA21 RAS p21 protein activator 2 78.97(n)
    82.52(a)
      424782  NM_001012929.1  NP_001012947.1 
    lizard
    (Anolis carolinensis)
    Reptilia RASA26
    RAS p21 protein activator 2
    83(a)
    1 ↔ 1
    3(22228762-22274452)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.74132 Xenopus laevis transcribed sequence with weak similarity more 76.29(n)    48040272 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01024201.16
    Uncharacterized protein
    68(a)
    1 ↔ 1
    18(39390278-39529481) ENSDARG00000078775
    fruit fly
    (Drosophila melanogaster)
    Insecta Gap13 RAS protein signal transduction RAS
    GTPase activator
    34(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea gap-13 GTPase activating protein (GAP) 29(a)   X(2227806-2230650)   --


    ENSEMBL Gene Tree for RASA2 (if available)
    TreeFam Gene Tree for RASA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RASA2 gene
    SYNGAP12  DAB2IP2  RASA42  RASA12  RASAL32  RASA4B2  RASAL22  RASA32  
    RASAL12  
    3 SIMAP similar genes for RASA2 using alignment to 2 protein entries:     RASA2_HUMAN (see all proteins):
    RASA3    RASA4    RASA4B

    Find genes that share paralogs with RASA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RASA2 (see all 2316)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445650841,2
    Cuntested1244154152(+) GTAATC/TGAGGA 2 I syn10--------
    rs117167761,2
    C,F,A,H--138578978(+) CTGACG/ACGGAT 1 -- us2k18Minor allele frequency- A:0.21NA WA 250
    rs1918799801,2
    --138579077(+) GGTGGC/TGCGCA 1 -- us2k10--------
    rs117168321,2
    C,H--138579243(+) aaagaG/AaaGAA 1 -- us2k1 trp31Minor allele frequency- A:0.00NA 2
    rs1428920681,2
    --138579336(+) GGATGC/TCTTTA 1 -- us2k10--------
    rs1461215821,2
    --138579349(+) AATAAC/GGGGGA 1 -- us2k10--------
    rs622820061,2
    C--138579402(+) TTTAAC/TAAGGG 1 -- us2k14Minor allele frequency- T:0.29NA EA 244
    rs1150580991,2
    C,F--138579734(+) CATTCT/GCTGGG 1 -- us2k12Minor allele frequency- G:0.02WA NA 238
    rs2020701011,2
    C--138579824(+) CTCTG-/CCTTTT 1 -- us2k10--------
    rs38066451,2
    C--138579825(+) CTGGCA/CTTTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RASA2 (141205889 - 141334184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RASA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676781CNV Deletion23128226
    esv1084666CNV Deletion17803354
    esv271649CNV Insertion20981092
    esv270683CNV Insertion20981092
    nsv237170CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601589    OMIM disorders: --

    2 diseases for RASA2:    
    About MalaCards
    kuru    neurofibromatosis

    1 disease from the University of Copenhagen DISEASES database for RASA2:
    Kuru encephalopathy

    Find genes that share disorders with RASA2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RASA2 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 1 77 6 17234759 (1), 1749934 (1), 8341688 (1), 10706287 (1) (see all 6)
    neurofibromatosis 52 1 1883874 (1)
    trophoblastic tumor 51 2 9689648 (1), 7747802 (1)
    hydatidiform mole 41.4 1 9250705 (1)
    multiple tumors 38.6 1 9689648 (1)
    genetic disorder 26.4 1 8341688 (1)
    choriocarcinoma 19.2 1 10712588 (1)
    tumors 13.2 14 9689648 (4), 12895371 (1), 18073375 (1), 17640920 (1) (see all 8)
    prostate cancer 11.6 8 9689648 (3), 18073375 (1), 20154697 (1)
    leukemia 0 2 8954928 (1), 8563750 (1)


    Export disorders for RASA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RASA2 gene, integrated from 10 sources (see all 155):
    (articles sorted by number of sources associating them with RASA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distinct subcellular localisations of the putative inositol 1,3,4,5- tetrakisphosphate receptors GAP1(IP4BP) and GAP1m result from the GAP1(IP4BP) PH domain directing plasma membrane targeting. (PubMed id 9382842)1, 2, 9 Lockyer P.J.... Cullen P.J. (Curr. Biol. 1997)
    2. [Heterogeneity of GTPase-activating proteins for Ras in the regulation of Ras signal transduction pathway]. (PubMed id 8699317)1, 3, 9 Hattori S. and Baba H. (Yakugaku Zasshi 1996)
    3. cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M), a GTPase-activating protein of Ras. (PubMed id 8812506)1, 2, 9 Li S.... Hattori S. (Genomics 1996)
    4. Human rasGTPase-activating protein (human counterpart of GAP1m): sequence of the cDNA, primary structure of the protein, production and chromosomal localization. (PubMed id 8917095)1, 2 Kobayashi M....Iwashita S. (Gene 1996)
    5. The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain. (PubMed id 9796816)1, 9 Jiang Y....Huang X.Y. (Nature 1998)
    6. Seventy-five genetic loci influencing the human red blood cell. (PubMed id 23222517)1 van der Harst P....Chambers J.C. (Nature 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (PubMed id 22210626)1 Mead S....Collinge J. (Hum. Mol. Genet. 2012)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5922 HGNC: 9872 AceView: RASA2 Ensembl:ENSG00000155903 euGenes: HUgn5922
    ECgene: RASA2 Kegg: 5922 H-InvDB: RASA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RASA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RASA2 gene:
    Search GeneIP for patents involving RASA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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