RASA2 Gene
protein-coding GIFtS: 55
GCID: GC03P141205
|
|
RAS p21 protein activator 2
| |
Aliases
for RASA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAS P21 Protein Activator 21 2 | | GAP1M1 2 3 5 | | GTPase-Activating Protein Of RAS2 | | Ras GTPase-Activating Protein 22 | | GAP1m3 | | RASGAP3 |
Export aliases for RASA2 gene to outside databasesPrevious GC identifers: GC03P138122 GC03P142034 GC03P142487 GC03P142526 GC03P142688 GC03P138580 |
Summaries
for RASA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RASA2:
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene productstimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RASfunction, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-boundform of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member hasa perinuclear localization and is an inositol 1,3,4,5-tetrakisphosphate-binding protein; a compound suggested tofunction as a second messenger. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RASA2_HUMAN, Q15283Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4)
|
Genomic Views
for RASA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RASA2 gene promoter:
ER-alpha RFX1 AML1a Ik-3 Tal-1beta LCR-F1 HNF-1A HNF-1 Sox9 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RASA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q22-q23 Ensembl cytogenetic band: 3q23 HGNC cytogenetic band: 3q22-q23RASA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P141205: view genomic region
(about GC identifiers)
Start:
|
141,205,889 bp from pter |
End:
|
141,334,184 bp from pter |
Size:
|
128,296 bases |
Orientation:
|
plus strand |
|
Proteins
for RASA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RASA2_HUMAN, Q15283 (See
protein sequence)Recommended Name: Ras GTPase-activating protein 2 Size: 849 amino acids; 96527 Da
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region
Secondary accessions: O00695 Q15284 Q92594 Q99577 Q9UEQ2Explore the universe of human proteins at neXtProt for RASA2: NX_Q15283
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15283
RASA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006497.2
ENSEMBL proteins: ENSP00000424293 ENSP00000286364 ENSP00000391677
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- | | GO:0005737 | cytoplasm |
IBA | -- | | GO:0031235 | intrinsic to internal side of plasma membrane |
IBA | -- | | GO:0043231 | intracellular membrane-bounded organelle |
IDA | -- | | GO:0048471 | perinuclear region of cytoplasm |
IEA | -- |
RASA2 for ontologies About GeneDecksing
RASA2 Antibody Products:
Assay Products for RASA2: |
Protein
Domains /
Families
for RASA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RASA2 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q15283ProtoNet protein and cluster: Q15283 4 Blocks protein families: IPB000008 C2 domain IPB001562 Tec/Btk domain signature IPB001849 Pleckstrin-like IPB001936 Ras GTPase-activating protein
UniProtKB/Swiss-Prot: RASA2_HUMAN, Q15283Similarity: Contains 1 Btk-type zinc fingerSimilarity: Contains 2 C2 domainsSimilarity: Contains 1 PH domainSimilarity: Contains 1 Ras-GAP domain |
Function
for RASA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RASA2_HUMAN, Q15283Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) Genatlas biochemistry entry for RASA2:RAS-p21 GTPase-activating protein,100 kDa,isoform placenta specific
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RASA2 (NM_006506) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RASA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASA2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RASA2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RASA2:
|
Pathways & Interactions
for RASA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling TC21 regulation pathway | | | 2 | MAPK signaling pathway | | | 3 | Development Angiotensin activation of ERK | | | 4 | G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for RASA2
4  GeneGo (Thomson Reuters) Pathways for RASA2
1  BioSystems Pathway for RASA2
1 
Kegg Pathway (Kegg details for RASA2):
RASA2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RASA2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for RASA2 (Q152833 ENSP000002863644) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
TAS | 8812506 | | GO:0032320 | positive regulation of Ras GTPase activity |
IBA | -- | | GO:0035556 | intracellular signal transduction |
IEA | -- | | GO:0046580 | negative regulation of Ras protein signal transduction |
IBA | -- | | GO:0051056 | regulation of small GTPase mediated signal transduction |
-- | -- |
RASA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for RASA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RASA2 for compounds About GeneDecksing
 Browse Tocris compounds for RASA2
10/13 Novoseek chemical compound relationships for RASA2 gene (see all 13) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gtp |
65.4 |
9 |
11389730 (1), 8621595 (1), 17094109 (1), 9468490 (1) (see all 7) |
| inositol 1,3,4,5-tetrakisphosphate |
65.2 |
2 |
9735347 (1), 10861245 (1) |
| phosphatidylinositol |
63.2 |
19 |
7692230 (2), 10463951 (2), 8164650 (1), 7743180 (1) (see all 16) |
| phosphotyrosine |
61.5 |
2 |
8890167 (1), 7961710 (1) |
| tyrosine |
60.4 |
29 |
8164650 (1), 8524223 (1), 10448070 (1), 10688886 (1) (see all 24) |
| gdp |
59.3 |
1 |
11389730 (1) |
| inositol |
34.8 |
2 |
10049724 (1), 11728827 (1) |
| guanine |
24.9 |
1 |
7622571 (1) |
| sphingosine |
17.9 |
4 |
10463951 (2), 12776187 (1) |
| arachidonic acid |
0 |
1 |
8576154 (1) |
Search CenterWatch for drugs/clinical trials and news about RASA2
|
Transcripts
for RASA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RASA2 gene: NM_006506.2 Unigene Cluster for RASA2: RAS p21 protein activator 2 Hs.655941 [show with all ESTs]Unigene Representative Sequence: AK2920167 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000515549 ENST00000286364(uc003etz.1) ENST00000505833 ENST00000509118
ENST00000509032 ENST00000506365 ENST00000452898(uc010huq.1 uc003eua.1 uc011bnc.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASA2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RASA2 (NM_006506) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RASA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASA2 |
Additional cDNA sequence: AB209161.1 AF115573.1 AK292016.1 AK301015.1 D78155.1 D82880.1 8 DOTS entries: DT.40254910 DT.40206898 DT.95353096 DT.40125189 DT.91792973 DT.100701847 DT.102839041 DT.91711273 24/115 AceView cDNA sequences (see all 115): R79815 CR620532 AW827184 NM_006506 BM543307 AI354628 BQ268939 AF115573 CK429938 AI683022 CA431012 AK025305 D82880 AL700400 BM968286 BM543304 BX484992 BF793566 BI856082 BM313623 CK905128 BP371272 BU935311 AW958914
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for RASA2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 26a | · | 26b |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | |
ECgene alternative splicing isoforms for RASA2
|
Expression
for RASA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RASA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RASA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RASA2
SOURCE GeneReport for Unigene cluster: Hs.655941
SABiosciences Custom PCR Arrays for RASA2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASA2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RASA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASA2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA2 |
Orthologs
for RASA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RASA2 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RASA21 |
RAS p21 protein activator 2 |
79.63(n)
83.37(a) |
|
424782 NM_001012929.1 NP_001012947.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RASA26 |
-- |
82(a) |
1 ↔ 1 |
3(22229026-22274083) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.74132 |
Xenopus laevis transcribed sequence with weak similarity more |
76.29(n) |
|
48040272 |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01024201.26 |
-- |
67(a) |
1 ↔ 1 |
18(39390278-39529481) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Gap13 |
RAS protein signal transduction RAS GTPase
activator |
34(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
gap-13 |
GTPase activating protein (GAP) |
29(a) |
|
X(2227806-2230650) -- |
ENSEMBL Gene Tree for RASA2 (if available)
TreeFam Gene Tree for RASA2 (if available) |
Paralogs
for RASA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RASA2 gene
- SYNGAP12 DAB2IP2 RASA42 RASA12 RASAL32 RASA4B2 RASA32 RASAL22
- RASAL12
4 SIMAP similar genes for RASA2 using alignment to 3 protein entries: RASA2_HUMAN (see all proteins):RASA3 RASA4 RASA4B RASAL1
RASA2 for paralogs About GeneDecksing
|
Genomic Variants
for RASA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RASA2 (141205889 - 141334184 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RASA2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RASA2 |
|
Disorders
/ Diseases
for RASA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RASA2 for disorders About GeneDecksing
OMIM gene information: 601589
OMIM disorders: --
16  diseases for RASA2: About MalaCardstropical spastic paraparesis juvenile myelomonocytic leukemia myelomonocytic leukemia spastic paraparesis
neurofibromatosis acute myeloid leukemia myeloproliferative disorder myeloid leukemia
neurofibroma choriocarcinoma prostate cancer leukemia
spasticity prostatitis lung cancer neuronitis
10/12 Novoseek disease relationships for RASA2 gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| neurofibromatosis type 1 |
77 |
6 |
17234759 (1), 1749934 (1), 8341688 (1), 10706287 (1) (see all 6) |
| neurofibromatosis |
52 |
1 |
1883874 (1) |
| trophoblastic tumor |
51 |
2 |
9689648 (1), 7747802 (1) |
| hydatidiform mole |
41.4 |
1 |
9250705 (1) |
| multiple tumors |
38.6 |
1 |
9689648 (1) |
| genetic disorder |
26.4 |
1 |
8341688 (1) |
| choriocarcinoma |
19.2 |
1 |
10712588 (1) |
| tumors |
13.2 |
14 |
9689648 (4), 12895371 (1), 18073375 (1), 17640920 (1) (see all 8) |
| prostate cancer |
11.6 |
8 |
9689648 (3), 18073375 (1), 20154697 (1) |
| leukemia |
0 |
2 |
8954928 (1), 8563750 (1) |
Export disorders for RASA2 gene to outside databases
|
Publications
for RASA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RASA2 gene, integrated from 9 sources (see all 151):
(articles sorted by number of sources associating them with RASA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Distinct subcellular localisations of the putative inositol 1,3,4,5- tetrakisphosphate receptors GAP1(IP4BP) and GAP1m result from the GAP1(IP4BP) PH domain directing plasma membrane targeting. (PubMed id 9382842)1, 2, 9 Lockyer P.J.... Cullen P.J. (1997)
- [Heterogeneity of GTPase-activating proteins for Ras in the regulation of Ras signal transduction pathway] (PubMed id 8699317)1, 3, 9 Hattori S. and Baba H. (1996)
- cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M), a GTPase-activating protein of Ras. (PubMed id 8812506)1, 2, 9 Li S.... Hattori S. (1996)
- Human rasGTPase-activating protein (human counterpart of GAP1m): sequence of the cDNA, primary structure of the protein, production and chromosomal localization. (PubMed id 8917095)1, 2 Kobayashi M....Iwashita S. (1996)
- The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain. (PubMed id 9796816)1, 9 Jiang Y....Huang X.Y. (1998)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (PubMed id 22210626)1 Mead S....Collinge J. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Protein profile of tax-associated complexes. (PubMed id 14530271)1 Wu K.... Kashanchi F. (2004)
|
External Searches for RASA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RASA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RASA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RASA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RASA2 gene:
Search GeneIP for patents involving RASA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RASA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RASA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RASA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RASA2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RASA2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RASA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RASA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RASA2 | | OriGene Custom Protein Services for RASA2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RASA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RASA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RASA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASA2 |
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| | | | Search Tocris compounds for RASA2 |
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 | | | RASA2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA2 |
|  |  |  | | | | Search ThermoFisher Antibodies for RASA2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASA2 |
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