Aliases for RASA2 Gene
External Ids for RASA2 Gene
Previous GeneCards Identifiers for RASA2 Gene
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for RASA2 Gene
RASA2 (RAS P21 Protein Activator 2) is a Protein Coding gene. Diseases associated with RASA2 include Noonan Syndrome 1 and Neurofibromatosis, Type 2. Among its related pathways are RET signaling and Immune System. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RASA3.
UniProtKB/Swiss-Prot for RASA2 Gene
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).