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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RASA1 Gene

protein-coding   GIFtS: 71
GCID: GC05P086565

RAS P21 Protein Activator (GTPase Activating Protein) 1


(Previous symbol: RASA)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAS P21 Protein Activator (GTPase Activating Protein) 11 2     RASGAP2
RASA1 2 3     p120RASGAP2
GAP2 3 5     Ras GTPase-Activating Protein 12
p120GAP2 3     Triphosphatase-Activating Protein2
CMAVM2 5     RasGAP3
PKWS2 5     GTPase-Activating Protein3
Capillary Malformation-Arteriovenous Malformation1     Ras P21 Protein Activator3
CM-AVM2     

External Ids:    HGNC: 98711   Entrez Gene: 59212   Ensembl: ENSG000001457157   OMIM: 1391505   UniProtKB: P209363   

Export aliases for RASA1 gene to outside databases

Previous GC identifers: GC05P085479 GC05P086779 GC05P086602 GC05P086648 GC05P086599 GC05P081768


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RASA1 Gene:
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating
proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart.
Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins
resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and
differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal
cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without
arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where
the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be
abundantly expressed in placental but not adult tissues. (provided by RefSeq, May 2012)

GeneCards Summary for RASA1 Gene: 
RASA1 (RAS p21 protein activator (GTPase activating protein) 1) is a protein-coding gene. Diseases associated with RASA1 include arteriovenous malformation, and parkes weber syndrome, and among its related super-pathways are Development Angiopoietin - Tie2 signaling and Development EGFR signaling pathway. GO annotations related to this gene include phospholipid binding and glycoprotein binding. An important paralog of this gene is SYNGAP1.

UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936
Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic
Ras p21; this stimulation may be further increased in the presence of NCK1

Gene Wiki entry for RASA1 (RAS p21 protein activator 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RASA1 gene promoter:
         PPAR-gamma1   NF-1/L   NF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RASA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RASA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RASA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3   Ensembl cytogenetic band:  5q14.3   HGNC cytogenetic band: 5q13

RASA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P086565:  view genomic region     (about GC identifiers)

Start:
86,563,705 bp from pter      End:
86,687,748 bp from pter
Size:
124,044 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936 (See protein sequence)
Recommended Name: Ras GTPase-activating protein 1  
Size: 1047 amino acids; 116403 Da
Subunit: Interacts with SQSTM1. Interacts with SPSB1; the interaction does not promote degradation. Interacts with
CAV2 (tyrosine phosphorylated form). Directly interacts with NCK1. Interacts with PDGFRB (tyrosine
phosphorylated). Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1
Subcellular location: Cytoplasm
6/8 PDB 3D structures from and Proteopedia for RASA1 (see all 8):
1WER (3D)        1WQ1 (3D)        2GQI (3D)        2GSB (3D)        2J05 (3D)        2J06 (3D)    
Secondary accessions: B2R6W3 Q9UDI1
Alternative splicing: 2 isoforms:  P20936-1   P20936-2   

Explore the universe of human proteins at neXtProt for RASA1: NX_P20936

Explore proteomics data for RASA1 at MOPED 

Post-translational modifications:

  • UniProtKB: The N-terminus is blocked
  • UniProtKB: Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity,
    whereas phosphorylation by LCK does not display any effect on stimulation activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20936

  • RASA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RASA1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002881.1  NP_072179.1  

    ENSEMBL proteins: 
     ENSP00000274376   ENSP00000423395   ENSP00000411221   ENSP00000422008   ENSP00000420905  
    Reactome Protein details: P20936
    Human Recombinant Protein Products for RASA1: 
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    Novus Biologicals RASA1 Proteins
    Novus Biologicals RASA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RASA1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005622intracellular ----
    GO:0005737cytoplasm NAS2821624
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ----

    RASA1 for ontologies           About GeneDecksing



    RASA1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for RASA1 
    Cloud-Clone Corp. CLIAs for RASA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing

    5/10 InterPro protein domains (see all 10):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR018029 C2_membr_targeting

    Graphical View of Domain Structure for InterPro Entry P20936

    ProtoNet protein and cluster: P20936

    5 Blocks protein domains:
    IPB000008 C2 domain
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain
    Similarity: Contains 2 SH2 domains
    Similarity: Contains 1 SH3 domain


    RASA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASA1_HUMAN, P20936
    Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic
    Ras p21; this stimulation may be further increased in the presence of NCK1

         Genatlas biochemistry entry for RASA1:
    Ras-p21 GTPase-activating protein,120kDa,GAP,involved in normal blood vessel development

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IPI8618896
    GO:0005096GTPase activator activity ----
    GO:0005099Ras GTPase activator activity IBA--
    GO:0005102receptor binding IPI2157284
    GO:0005515protein binding IPI1314164
         
    RASA1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RASA1:
     Decreased cell number and incr  Increased cell death HMECs cel 

         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rasa1):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hearing/vestibular/ear  immune system  limbs/digits/tail  mortality/aging 
     muscle  nervous system  no phenotypic analysis 

    RASA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rasa1tm1Paw for RASA1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RASA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RASA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASA1 

    miRNA
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    miRTarBase miRNAs that target RASA1:
    hsa-mir-335 (MIRT003230)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RASA1
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate RASA1 (see all 40):
    hsa-miR-30d hsa-miR-301a hsa-miR-223 hsa-miR-30a hsa-miR-130b hsa-miR-4257 hsa-miR-301b hsa-miR-499-3p
    SwitchGear 3'UTR luciferase reporter plasmidRASA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of RASA1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RASA1 About   (see all 45)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development PDGF signaling via STATs and NF-kB
    Development Angiopoietin - Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    Angiopoietin-TIE2 Signaling0.36
    2Development EGFR signaling pathway
    Development EGFR signaling pathway0.87
    GDNF-Family Ligands and Receptor Interactions0.41
    Development GDNF family signaling0.45
    EGF Pathway0.41
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4Development EPO-induced Jak-STAT pathway
    Development EPO-induced Jak-STAT pathway0.42
    EPO Receptor Signaling0.42
    5Development HGF signaling pathway
    Development EGFR signaling via small GTPases0.44
    Signaling of Hepatocyte Growth Factor Receptor0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/15 EMD Millipore Pathways for RASA1 (see all 15)
        G-protein signaling Regulation of CDC42 activity
    Development Angiopoietin - Tie2 signaling
    Development VEGF signaling and activation
    Chemotaxis CXCR4 signaling pathway
    G-protein signaling M-RAS regulation pathway

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RASA1 (see all 14)
        Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling
    G12-G13 in Cellular Signaling
    GDNF-Family Ligands and Receptor Interactions

    5/15 GeneGo (Thomson Reuters) Pathways for RASA1 (see all 15)
        G-protein signaling H-RAS regulation pathway
    G-protein signaling M-RAS regulation pathway
    Development VEGF signaling via VEGFR2 - generic cascades
    Development EGFR signaling pathway
    Development EGFR signaling via small GTPases

    5/23 BioSystems Pathways for RASA1 (see all 23)
        MAPK signaling pathway
    EGFR1 Signaling Pathway
    EPO Receptor Signaling
    IL-4 signaling Pathway
    Kit Receptor Signaling Pathway

    3        Reactome Pathways for RASA1
        Downstream signal transduction
    Signal Transduction
    Signaling by PDGF


    2         Kegg Pathways  (Kegg details for RASA1):
        MAPK signaling pathway
    Axon guidance


    RASA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RASA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/140 Interacting proteins for RASA1 (P209361, 2, 3 ENSP000002743764) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74698 MINT-74702 MINT-74697 MINT-74701 MINT-74699 MINT-74712 MINT-74700 I2D: score=2 STRING: ENSP00000269571
    PDGFRBP096192, 3, ENSP000002617994MINT-8026988 MINT-8026958 MINT-8026973 I2D: score=5 STRING: ENSP00000261799
    CAPNS1P046322, 3, ENSP000002465334MINT-7304956 MINT-7304983 MINT-7304902 I2D: score=1 STRING: ENSP00000246533
    ABI1Q8IZP02, 3, ENSP000003653124MINT-7908187 MINT-7908586 I2D: score=1 STRING: ENSP00000365312
    CD5P061272, 3, ENSP000003426814MINT-8037472 I2D: score=4 STRING: ENSP00000342681
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis ISS--
    GO:0001570vasculogenesis ISS--
    GO:0001953negative regulation of cell-matrix adhesion IDA8344248
    GO:0007162negative regulation of cell adhesion IDA8344248
    GO:0007165signal transduction IDA1756860

    RASA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RASA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for RASA1

    Browse Tocris compounds for RASA1

    10/13 Novoseek inferred chemical compound relationships for RASA1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 72.9 21 9312123 (3), 8262937 (2), 7492562 (1), 8607981 (1) (see all 15)
    tyrosine 69.4 76 10567236 (5), 10688886 (4), 8408058 (3), 15030317 (2) (see all 39)
    gdp 58.1 5 17052120 (1), 8909796 (1), 9312123 (1), 15774489 (1)
    phosphotyrosine 53.4 3 15030317 (1), 10391888 (1)
    guanine 27.4 1 7622571 (1)
    phosphatidylinositol 26.3 4 1328986 (1), 7898923 (1), 15763428 (1), 8816504 (1)
    arginine 22.4 8 11412100 (3), 15340059 (2), 9668168 (1)
    guanosine 12.3 2 9731575 (1)
    phenylalanine 6.07 1 8408058 (1)
    serine 3.17 1 16314845 (1)

    Search CenterWatch for drugs/clinical trials and news about RASA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RASA1 gene (2 alternative transcripts): 
    NM_002890.2  NM_022650.2  

    Unigene Cluster for RASA1:

    RAS p21 protein activator (GTPase activating protein) 1
    Hs.664080  [show with all ESTs]
    Unigene Representative Sequence: CR749722
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274376 ENST00000515800(uc003kiw.3 uc010jav.3) ENST00000456692(uc003kix.3 uc011ctv.2 uc011ctw.2 uc010jaw.3)
    ENST00000512763 ENST00000506290 ENST00000509953
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate RASA1 (see all 40):
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASA1
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASA1

    Additional mRNA sequence: 

    AB209106.1 AK300263.1 AK300269.1 AK300406.1 AK312739.1 BC020761.1 BC033015.2 BC054891.1 
    BC070063.1 BC107870.1 BC131816.1 CR749722.1 M23379.1 M23612.1 

    24/36 DOTS entries (see all 36):

    DT.92454258  DT.100833161  DT.92454256  DT.92454259  DT.100689204  DT.120829242  DT.421222  DT.75191555 
    DT.92454254  DT.95186287  DT.97820076  DT.40260770  DT.436627  DT.40226058  DT.95186278  DT.75146302 
    DT.40198236  DT.91657462  DT.95186275  DT.95186306  DT.95186310  DT.100786289  DT.120829251  DT.120829312 

    24/282 AceView cDNA sequences (see all 282):

    AU138673 AW192176 AU137957 CF528258 AU139436 AA872525 BX475533 AA251808 
    BM846040 AU137697 AU138236 NM_002890 BM469504 BG434837 AU136635 BI260695 
    AL044995 BG621519 AU138739 AA301373 CD172265 BM455842 BE501681 BX503514 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RASA1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RASA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RASA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACCCATTC
    RASA1 Expression
    About this image


    See RASA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RASA1

    SOURCE GeneReport for Unigene cluster: Hs.664080

    UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936
    Tissue specificity: In placental villi, detected only in the trophoblast layer (cytotrophoblast and
    syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including RASA1 (see all 6): 
              Angiogenic Growth Factors in human mouse rat
              Telomeres & Telomerase in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RASA1
    OriGene qSTAR qPCR primer pairs in human, mouse for RASA1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RASA1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RASA1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RASA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RASA1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasa11 , 5 RAS p21 protein activator 11, 5 91.39(n)1
    95.95(a)1
      13 (45.05 cM)5
    2183971  NM_145452.31  NP_663427.21 
     852147805 
    chicken
    (Gallus gallus)
    Aves RASA11 RAS p21 protein activator (GTPase activating protein) more 82.12(n)
    89.9(a)
      427327  XM_424907.3  XP_424907.3 
    lizard
    (Anolis carolinensis)
    Reptilia RASA16
    Uncharacterized protein
    83(a)
    1 ↔ 1
    2(20823673-20889265)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.285652 Xenopus laevis transcribed sequence with strong similarity more 80.71(n)    BI314837.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF347677.12   -- 77.34(n)    CF347677.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vap1 , 3 RAS GTPase activator3
    vacuolar peduncle1
    46(a)3
    52.28(n)1
    49.04(a)1
      325691  NM_078637.21  NP_523361.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BUD26
    GTPase activating factor for Rsr1p/Bud1p required ...
    11(a)
    1 → many
    XI(266145-269459)


    ENSEMBL Gene Tree for RASA1 (if available)
    TreeFam Gene Tree for RASA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RASA1 gene
    SYNGAP12  DAB2IP2  RASA42  RASAL32  RASA22  RASA4B2  RASAL22  RASA32  
    RASAL12  
    4 SIMAP similar genes for RASA1 using alignment to 5 protein entries:     RASA1_HUMAN (see all proteins):
    DKFZp434N071    PTPN11    GRAP2    GRAPL

    RASA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2132 SNPs in RASA1 are shown (see all 2132)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0177444
    Capillary malformation-arteriovenous malformation (CMAVM)4--see VAR_0177442 C Y mis40--------
    VAR_0026504
    Basal cell carcinomas4--see VAR_0026502 R L mis40--------
    VAR_0026524
    Basal cell carcinomas4--see VAR_0026522 I V mis40--------
    VAR_0026514
    Basal cell carcinomas4--see VAR_0026512 K E mis40--------
    rs38405221,2
    C--86563775(+) CCCCA-/ACCCCT 2 -- us2k10--------
    rs1998827181,2
    C--86576743(+) TTTTT-/TGAGGC 2 -- int10--------
    rs2004615111,2
    C--86578965(+) TTTTT-/TGGTTG 2 -- int10--------
    rs342170121,2
    C--86580850(+) GTACCATTT/-  
            
    ATTTA
    2 -- int11Minor allele frequency- -:0.50NA 2
    rs1113042951,2
    F--86582667(+) ATATAC/TACACC 2 -- int12Minor allele frequency- T:0.33CSA 3
    rs623689401,2
    --86583849(+) ATATAC/TATATA 2 -- int10--------

    HapMap Linkage Disequilibrium report for RASA1 (86563705 - 86687748 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RASA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv327831CNV Loss16902084
    nsv830379CNV Gain17160897


    Human Gene Mutation Database (HGMD): RASA1

    Locus Specific Mutation Databases (LSDB): RASA1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RASA1
    DNA2.0 Custom Variant and Variant Library Synthesis for RASA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 139150   
    OMIM disorders: 608355  608354  605462  
    UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936
  • Note=Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas
  • Capillary malformation-arteriovenous malformation (CMAVM) [MIM:608354]: Disorder characterized by
    atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These
    capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes
    Weber syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Parkes Weber syndrome (PKWS) [MIM:608355]: Disorder characterized by a cutaneous flush with underlying
    multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected
    limb. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/35 diseases for RASA1 (see all 35):    About MalaCards
    arteriovenous malformation    parkes weber syndrome    vein of galen aneurysm    rasa1-related disorders
    parkes weber syndrome, rasa1-related    parkes weber slndrome    capillary malformation-arteriovenous malformation syndrome    weber syndrome
    sturge-weber syndrome    basal cell carcinoma, somatic    basal cell carcinoma    neurofibromatosis
    klippel-trenaunay syndrome    juvenile myelomonocytic leukemia    acute lymphocytic leukemia    choriocarcinoma
    gout    was-related disorders    myeloid leukemia    nasopharyngitis

    3 diseases from the University of Copenhagen DISEASES database for RASA1:
    Neurofibromatosis     Klippel-Trenaunay syndrome     Arteriovenous malformation

    RASA1 for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for RASA1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 1 75.4 6 1620552 (1), 8246952 (1), 17096025 (1), 18218617 (1) (see all 6)
    trophoblastic tumor 47.5 4 7747802 (2), 8738474 (1)
    myeloid leukemia chronic 37.7 1 1571536 (1)
    neurofibromatosis 37.3 2 1904555 (2)
    choriocarcinoma 27.4 2 7747802 (1)
    multiple tumors 22.6 1 9521474 (1)
    tumors 14.2 20 9521474 (3), 8738474 (3), 17096025 (1), 1368795 (1) (see all 13)
    necrosis 4.41 1 17389591 (1)
    carcinoma basal cell 3.87 2 9521474 (1), 8738474 (1)
    cancer 1.65 1 17096025 (1)

    Genetic Association Database (GAD): RASA1
    Human Genome Epidemiology (HuGE) Navigator: RASA1 (14 documents)

    Export disorders for RASA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RASA1 gene, integrated from 9 sources (see all 330) (see top 10):
    (articles sorted by number of sources associating them with RASA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations. (PubMed id 14639529)1, 2, 9 Eerola I.... Vikkula M. (2003)
    2. Purification, characterization, and cellular localization of the 100- kDa human placental GTPase-activating protein. (PubMed id 8360177)1, 2, 9 Zhang Y....Thane M.N. (1993)
    3. Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27). (PubMed id 15504032)1, 2, 9 Wang X.B....Lisanti M.P. (2004)
    4. Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho- caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. (PubMed id 12091389)1, 2, 9 Lee H....Lisanti M.P. (2002)
    5. Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm. (PubMed id 11389730)1, 2, 9 Giglione C....Parmeggiani A. (2001)
    6. Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity. (PubMed id 21664272)1, 2 Ger M.... Valius M. (2011)
    7. High-frequency type I/II mutational shifts between di agnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine. (PubMed id 20592250)1, 4 Bachas C....Cloos J. (2010)
    8. Identification of several novel non-p.R132 IDH1 varia nts in thyroid carcinomas. (PubMed id 20702649)1, 4 Hemerly J.P....Cerutti J.M. (2010)
    9. Backtracking RAS mutations in high hyperdiploid child hood acute lymphoblastic leukemia. (PubMed id 20688547)1, 4 Wiemels J.L....Wiencke J.K. (2010)
    10. Genome wide molecular analysis of minimally different iated acute myeloid leukemia. (PubMed id 19773259)1, 4 Silva F.P....Giphart-Gassler M. (2009)
    11. The ERAP2 gene is associated with preeclampsia in Aus tralian and Norwegian populations. (PubMed id 19578876)1, 4 Johnson M.P....Moses E.K. (2009)
    12. PIK3CA mutation occurs in nasopharyngeal carcinoma but does not significantly influence the disease-specific survival. (PubMed id 19012001)1, 4 Chou C.C....Tzen C.Y. (2008)
    13. Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer. (PubMed id 18024870)1, 4 Tsao M.S....Shepherd F.A. (2007)
    14. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PubMed id 15713673)1, 2 Wang D....Wu G. (2005)
    15. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    16. RASA1: variable phenotype with capillary and arteriovenous malformations. (PubMed id 15917201)1, 3 Boon L.M....Vikkula M. (2005)
    17. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    18. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. (PubMed id 9219684)1, 2 Scheffzek K.... Wittinghofer A. (1997)
    19. Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras. (PubMed id 8955277)1, 2 Scheffzek K....Wittinghofer A. (1996)
    20. Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region. (PubMed id 8618896)1, 2 Park I.... Shin J. (1995)
    21. Solution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence. (PubMed id 8137811)1, 2 Yang Y.S.... Roques B.P. (1994)
    22. Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours. (PubMed id 8275088)1, 2 Friedman E.... McCormick F. (1993)
    23. Purification, characterization, and western blot analysis of human GTPase-activating protein from native and recombinant sources. (PubMed id 2123878)1, 2 Halenbeck R.... Koths K. (1990)
    24. Molecular cloning of two types of GAP complementary DNA from human placenta. (PubMed id 3201259)1, 2 Trahey M.... McCormick F. (1988)
    25. Proteolytic cleavage of ras GTPase-activating protein during apoptosis. (PubMed id 10200531)1, 9 Wen L.P....Rosen G.D. (1998)
    26. RASA1 mutations may cause hereditary capillary malformations without arteriovenous malformations. (PubMed id 18363760)1, 9 Hershkovitz D....Lapidot M. (2008)
    27. Sam68 association with p120GAP in CD4+ T cells is dependent on CD4 molecule expression. (PubMed id 9743338)1, 9 Jabado N....Hivroz C. (1998)
    28. Binding of the H-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro. (PubMed id 1633149)1, 9 Serth J....Pingoud A. (1992)
    29. Essential roles for Dok2 and RasGAP in CD200 receptor -mediated regulation of human myeloid cells. (PubMed id 19786546)1, 9 Mihrshahi R....Brown M.H. (2009)
    30. Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions. (PubMed id 15542850)1, 9 Yang J.Y....Widmann C. (2004)
    31. Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. (PubMed id 18446851)1, 9 Revencu N....Vikkula M. (2008)
    32. RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP. (PubMed id 11350068)1, 9 Koehler J.A. and Moran M.F. (2001)
    33. Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain. (PubMed id 10708762)1, 9 Chow A....Gawler D.J. (2000)
    34. Role of p120 Ras-GAP in directed cell movement. (PubMed id 10769036)1, 9 Kulkarni S.V....Pawson T. (2000)
    35. Ras-GTPase activating protein (GAP): a putative effector for Ras. (PubMed id 9113414)1, 9 Tocque B....Schweighoffer F. (1997)
    36. Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines. (PubMed id 1571536)1, 9 Druker B....Griffin J.D. (1992)
    37. p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities. (PubMed id 19151751)1, 9 Yang X.Y....Popescu N.C. (2009)
    38. Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling. (PubMed id 11604231)1, 9 Sanchez-Margalet V. and Najib S. (2001)
    39. Species specificity and organ, cellular and subcellular localization of the 100 kDa Ras GTPase activating protein. (PubMed id 8006063)1, 9 Mollat P....Thang M.N. (1994)
    40. SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor. (PubMed id 11896619)1, 9 Ekman S....Ronnstrand L. (2002)
    41. RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion. (PubMed id 10713673)1, 9 Zrihan-Licht S....Avraham H. (2000)
    42. A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability. (PubMed id 9632780)1, 9 Gallouzi I.E....Tazi J. (1998)
    43. Normal p21Ras/MAP kinase pathway expression and function in PBMC from patients with polycystic ovary disease. (PubMed id 15010862)1, 9 Buchs A....Rapoport M.J. (2004)
    44. Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras. (PubMed id 11331873)1, 9 Cacalano N.A....Johnston J.A. (2001)
    45. Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling. (PubMed id 10799545)1, 9 Nemorin J.G. and Duplay P. (2000)
    46. Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation. (PubMed id 10669731)1, 9 Becker E....Skolnik E.Y. (2000)
    47. The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. (PubMed id 10822173)1, 9 Dunant N.M.... Resh M.D. (2000)
    48. Signaling transduction pathway of angiotensin II in human mesangial cells: mediation of focal adhesion and GTPase activating proteins. (PubMed id 10092539)1, 9 Shikata Y....Makino H. (1999)
    49. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. (PubMed id 9233798)1, 9 Holland S.J....Pawson T. (1997)
    50. Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. (PubMed id 9008161)1, 9 Yamanashi Y. and Baltimore D. (1997)
    51. Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation. (PubMed id 9034330)1, 9 Hu K.Q. and Settleman J. (1997)
    52. SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes. (PubMed id 9079622)1, 9 Liu Y.F....Devys D. (1997)
    53. Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man. (PubMed id 23650393)1 Burrows P.E....Sevick-Muraca E.M. (2013)
    54. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase a ctivating protein 1 (RASA1). (PubMed id 23322774)1 Sun D....Zhang J. (2013)
    55. Common genetic variation and antidepressant efficacy i n major depressive disorder: a meta-analysis of three genome-wide pharmacogeneti c studies. (PubMed id 23377640)1 (2013)
    56. Negative regulation of the RalGAP complex by 14-3-3. (PubMed id 23386617)1 Leto D....Saltiel A.R. (2013)
    57. RASA1 analysis: clinical and molecular findings in a s eries of consecutive cases. (PubMed id 22200646)1 Wooderchak-Donahue W....Bayrak-Toydemir P. (2012)
    58. Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations . (PubMed id 22949691)1 Rudack T....Gerwert K. (2012)
    59. Capillary malformation-arteriovenous malformation synd rome: identification of a family with a novel mutation. (PubMed id 23158644)1 Boyden L.M....King B.A. (2012)
    60. SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential inter actome. (PubMed id 22974441)1 Liu B.A....Nash P.D. (2012)
    61. Phenotypic variability in a family with capillary malf ormations caused by a mutation in the RASA1 gene. (PubMed id 22342634)1 de Wijn R.S....van der Horst C.M. (2012)
    62. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    63. Ras mutation cooperates with I^-catenin activation to drive bladder tumourigenesis. (PubMed id 21368895)1 Ahmad I....Sansom O.J. (2011)
    64. A role for p120 RasGAP in thymocyte positive selectio n and survival of naive T cells. (PubMed id 21646295)1 Lapinski P.E....King P.D. (2011)
    65. Revisiting G3BP1 as a RasGAP binding protein: sensitiz ation of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not inv olve G3BP1. (PubMed id 22205990)1 Annibaldi A....Widmann C. (2011)
    66. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    67. Competitive binding of Rab21 and p120RasGAP to integr ins regulates receptor traffic and migration. (PubMed id 21768288)1 Mai A....Ivaska J. (2011)
    68. Ca2+-dependent monomer and dimer formation switches C APRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities. (PubMed id 21460216)1 Dai Y....Lockyer P.J. (2011)
    69. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    70. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    71. Detection of RASA1 mutations in patients with sporadi c Sturge-Weber syndrome. (PubMed id 20821215)1 Zhou Q....Qin Z.P. (2011)
    72. Semaphorin 4D/Plexin-B1 stimulates PTEN activity thro ugh R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons. (PubMed id 20610402)1 Oinuma I....Negishi M. (2010)
    73. A novel association between RASA1 mutations and spina l arteriovenous anomalies. (PubMed id 20007727)1 Thiex R....Orbach D.B. (2010)
    74. MicroRNA-132-mediated loss of p120RasGAP activates th e endothelium to facilitate pathological angiogenesis. (PubMed id 20676106)1 Anand S....Cheresh D.A. (2010)
    75. Meta-analysis of genome-wide association studies for personality. (PubMed id 21173776)1 de Moor M.H....Boomsma D.I. (2010)
    76. A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. (PubMed id 19435801)1 Tomar A....Schlaepfer D.D. (2009)
    77. Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation. (PubMed id 18784923)1 Raepple D....Scheele J.S. (2009)
    78. Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. (PubMed id 19843518)1 Tong Y....Buck M. (2009)
    79. Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration. (PubMed id 18761085)1 Pamonsinlapatham P....Vidal M. (2008)
    80. Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation. (PubMed id 18556463)1 Madonna S....Albanesi C. (2008)
    81. Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. (PubMed id 18024423)2 Yang K.J....Park J. (2008)
    82. A novel mutation in RASA1 causes capillary malformation and limb enlargement. (PubMed id 18327598)1 Hershkovitz D....Sprecher E. (2008)
    83. Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications. (PubMed id 18067320)1 Polverini E....Harauz G. (2008)
    84. XB130, a novel adaptor protein for signal transduction. (PubMed id 17412687)1 Xu J....Liu M. (2007)
    85. A quantitative protein interaction network for the ErbB receptors using protein microarrays. (PubMed id 16273093)1 Jones R.B....MacBeath G. (2006)
    86. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    87. Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane. (PubMed id 16971514)1 Bradley W.D....Koleske A.J. (2006)
    88. Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion. (PubMed id 16046410)1 Yang J.Y....Widmann C. (2005)
    89. Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival. (PubMed id 15688026)1 Patrussi L....Baldari C.T. (2005)
    90. EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase. (PubMed id 16051609)1 Parri M....Chiarugi P. (2005)
    91. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    92. Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells. (PubMed id 15077193)1 Hecker T.P....Gladson C.L. (2004)
    93. The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. (PubMed id 15121898)1 Villace P....Ortin J. (2004)
    94. The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase. (PubMed id 15187129)1 Flaxenburg J.A....Pal S. (2004)
    95. Up-regulation of p21 gene expression by peroxisome proliferator-activated receptor gamma in human lung carcinoma cells. (PubMed id 15041706)1 Han S....Roman J. (2004)
    96. Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. (PubMed id 12679785)1 Kunath T....Rossant J. (2003)
    97. Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras. (PubMed id 12730209)1 Yunoue S....Araki N. (2003)
    98. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. (PubMed id 12730241)1 Cai D.... Shoelson S.E. (2003)
    99. Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling. (PubMed id 12112020)1 Najib S. and Sanchez-Margalet V. (2002)
    100. The RasGAP N-terminal fragment generated by caspase cleavage protects cells in a Ras/PI3K/Akt-dependent manner that does not rely on NFkappa B activation. (PubMed id 11847220)1 Yang J.Y. and Widmann C. (2002)
    101. The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells. (PubMed id 11751853)1 Kapila Y.L....Mass M.J. (2002)
    102. Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins. (PubMed id 11976319)1 Gigoux V....Garbay C. (2002)
    103. Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex. (PubMed id 12441060)1 Lamprecht R....LeDoux J.E. (2002)
    104. Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling. (PubMed id 12151397)1 Spiegelman V.S....Fuchs S.Y. (2002)
    105. The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. (PubMed id 11786539)1 Nancy V....de Gunzburg J. (2002)
    106. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    107. Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation. (PubMed id 11536198)1 Wolf R.M....Resh M.D. (2001)
    108. Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt. (PubMed id 11551902)1 Wick M.J.... Liu F. (2001)
    109. A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein. (PubMed id 11116152)1 Trentin G.A....Rozakis-Adcock M. (2001)
    110. Specificity of the binding of synapsin I to Src homology 3 domains. (PubMed id 10899172)1 Onofri F....Benfenati F. (2000)
    111. Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells. (PubMed id 11071635)1 van Dijk T.B....von Lindern M. (2000)
    112. Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. (PubMed id 10644995)1 Zisch A.H....Pasquale E.B. (2000)
    113. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. (PubMed id 10790433)1 Brdicka T.... Schraven B. (2000)
    114. Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia. (PubMed id 10187839)1 Chow C.W....Orlowski J. (1999)
    115. GM1 inhibits early signaling events mediated by PDGF receptor in cultured human glioma cells. (PubMed id 10697503)1 Farooqui T....Yates A.J. (1999)
    116. 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells. (PubMed id 10319320)1 D'Angelo G....Weiner R.I. (1999)
    117. Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation. (PubMed id 10508618)1 Jones N. and Dumont D.J. (1999)
    118. Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration. (PubMed id 10202139)1 Noguchi T....Kasuga M. (1999)
    119. Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck. (PubMed id 10428862)1 Lock P....Dunn A.R. (1999)
    120. Mapping the site of interaction between annexin VI and the p120GAP C2 domain. (PubMed id 10571081)1 Chow A. and Gawler D. (1999)
    121. Thymocyte activation induces the association of the proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5. (PubMed id 9603468)1 Dennehy K.M....Beyers A.D. (1998)
    122. Interactions of p62(dok) with p210(bcr-abl) and Bcr-Ab l-associated proteins. (PubMed id 9822717)1 Bhat A....Druker B.J. (1998)
    123. Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions. (PubMed id 9674711)1 Hock B....Strebhardt K. (1998)
    124. Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins. (PubMed id 9478921)1 Di Cristofano A.... Resh M.D. (1998)
    125. Guanosine triphosphatase-activating protein-associated protein, but not src-associated protein p68 in mitosis, is a part of insulin signaling complexes. (PubMed id 9564850)1 Sung C.K....Sanchez-Margalet V. (1998)
    126. ALK, the chromosome 2 gene locus altered by the t(2;5) in non- Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). (PubMed id 9174053)1 Morris S.W....Witte D.P. (1997)
    127. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1 Pirozzi G.... Fowlkes D.M. (1997)
    128. CD4 ligands inhibit the formation of multifunctional transduction complexes involved in T cell activation. (PubMed id 8977179)1 Jabado N....Hivroz C. (1997)
    129. Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells. (PubMed id 9218456)1 Li H.L....Pure E. (1997)
    130. Sam68 from an immortalised B-cell line associates with a subset of SH3 domains. (PubMed id 8766817)1 Finan P.M....Kellie S. (1996)
    131. The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP. (PubMed id 8798684)1 Davis A.J....Gawler D.J. (1996)
    132. p120 Ras GTPase-activating protein interacts with Ras-GTP through specific conserved residues. (PubMed id 8663024)1 Miao W....Marshall M.S. (1996)
    133. Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways. (PubMed id 8890167)1 Roche S....Courtneidge S.A. (1996)
    134. A Ras-GTPase-activating protein SH3-domain-binding protein. (PubMed id 8649363)1 Parker F.... Tocque B. (1996)
    135. Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines. (PubMed id 8570203)1 Lee J.M....Branton P.E. (1996)
    136. Cloning and characterization of GRB14, a novel member of the GRB7 gene family. (PubMed id 8647858)1 Daly R.J.... Sutherland R.L. (1996)
    137. Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. (PubMed id 7760813)1 Neumeister E.N....Shaw A.S. (1995)
    138. Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein. (PubMed id 7642582)1 Seely B.L....Olefsky J.M. (1995)
    139. The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck. (PubMed id 7782336)1 Briggs S.D....Smithgall T.E. (1995)
    140. Ras binding to a C-terminal region of GAP. (PubMed id 7628625)1 Molloy D.P....Grand R.J. (1995)
    141. p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. (PubMed id 8537347)1 Burbelo P.D....Yamada Y. (1995)
    142. The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src. (PubMed id 7544435)1 Neet K. and Hunter T. (1995)
    143. Functional interaction between c-Src and its mitotic target, Sam 68. (PubMed id 7537265)1 Taylor S.J....Shalloway D. (1995)
    144. Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo. (PubMed id 8084603)1 Kozutsumi H....Hirai H. (1994)
    145. Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines. (PubMed id 8270251)1 Mitsudomi T....Gazdar A.F. (1994)
    146. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. (PubMed id 8155326)1 Stephens R.M....Kaplan D.R. (1994)
    147. Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1. (PubMed id 7689724)1 Larose L....Pawson T. (1993)
    148. RASA1-Related Disorders (PubMed id 21348050)1 Bayrak-Toydemir P. and Stevenson D. (1993)
    149. Tyrosine 785 is a major determinant of Trk--substrate interaction. (PubMed id 8384556)1 Obermeier A....Ullrich A. (1993)
    150. The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. (PubMed id 8344248)1 McGlade J....Pawson T. (1993)
    151. Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. (PubMed id 8395016)1 Pleiman C.M....Cambier J.C. (1993)
    152. Phosphorylation of the ras GTPase-activating protein (GAP) by the p93c-fes protein-tyrosine kinase in vitro and formation of GAP-fes complexes via an SH2 domain-dependent mechanism. (PubMed id 7691175)1 Hjermstad S.J....Smithgall T.E. (1993)
    153. Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. (PubMed id 1314164)1 Kashishian A.... Cooper J.A. (1992)
    154. A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. (PubMed id 1383690)1 Muller A.J....Witte O.N. (1992)
    155. Agonist-induced association of the p21ras GTPase-activating protein with phosphatidylinositol 3-kinase. (PubMed id 1336372)1 Sjolander A. and Lapetina E.G. (1992)
    156. GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents. (PubMed id 1553544)1 Martin G.A....McCormick F. (1992)
    157. An interaction between p21ras and heat shock protein hsp60, a chaperonin. (PubMed id 1347942)1 Ikawa S. and Weinberg R.A. (1992)
    158. Interaction between the p21ras GTPase activating protein and the insulin receptor. (PubMed id 1331107)1 Pronk G.J....Bos J.L. (1992)
    159. GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit. (PubMed id 1375321)2 Kazlauskas A....Valius M. (1992)
    160. Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62. (PubMed id 1385407)1 Marengere L.E. and Pawson T. (1992)
    161. Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus. (PubMed id 1581965)1 Settleman J....Weinberg R.A. (1992)
    162. p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets. (PubMed id 1544885)1 Cichowski K....Brugge J.S. (1992)
    163. Activated Src tyrosine kinase phosphorylates Tyr-457 of bovine GTPase-activating protein (GAP) in vitro and the corresponding residue of rat GAP in vivo. (PubMed id 1512257)1 Park S....Jove R. (1992)
    164. Multiple SH2-mediated interactions in v-src-transformed cells. (PubMed id 1545818)1 Koch C.A....Pawson T. (1992)
    165. The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains. (PubMed id 1850098)1 Liu X.Q. and Pawson T. (1991)
    166. Identification of amino acid residues of Ras protein that are essential for signal-transducing activity but not for enhancement of G TPase activity by GAP. (PubMed id 1756860)1 Fujita-Yoshigaki J....Yokoyama S. (1991)
    167. Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein. (PubMed id 1717825)1 Brott B.K....Jove R. (1991)
    168. Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product. (PubMed id 2164710)1 Frech M....Wittinghofer A. (1990)
    169. The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma. (PubMed id 2176151)1 Margolis B....Schlessinger J. (1990)
    170. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. (PubMed id 1689011)1 Ellis C....Pawson T. (1990)
    171. Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor. (PubMed id 2172781)1 Reedijk M....Pawson T. (1990)
    172. Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. (PubMed id 2173144)1 Anderson D....Pawson T. (1990)
    173. Chromosomal localization of the gene encoding GTPase-activating protein (RASA) to human chromosome 5, bands q13-q15. (PubMed id 2307479)1 Lemons R.S....Le Beau M.M. (1990)
    174. Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP). (PubMed id 2122974)1 Gibbs J.B....Vogel U.S. (1990)
    175. ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels. (PubMed id 2188736)1 Yatani A....Brown A.M. (1990)
    176. Binding of GAP to activated PDGF receptors. (PubMed id 2157284)1 Kazlauskas A....Cooper J.A. (1990)
    177. Chromosome localization and cDNA sequence of murine and human genes for ras p21 GTPase activating protein (GAP). (PubMed id 2574500)1 Hsieh C.L....Francke U. (1989)
    178. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. (PubMed id 2833817)1 Adari H....McCormick F. (1988)
    179. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. (PubMed id 2821624)1 Trahey M. and McCormick F. (1987)
    180. Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src. (PubMed id 10567236)9 Schlesinger T.K....Kazlauskas A. (1999)
    181. RasGTPase-activating protein is a target of caspases in spontaneous apoptosis of lung carcinoma cells and in response to etoposide. (PubMed id 14742324)9 Bartling B....Zhivotovsky B. (2004)
    182. Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity. (PubMed id 15940262)9 Grewal T....Enrich C. (2005)
    183. The role of ras GTPase activating protein in human tumorigenesis. (PubMed id 8738474)9 Friedman E. (1995)
    184. Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse. (PubMed id 19458235)9 Endo M. and Yamashita T. (2009)
    185. A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. (PubMed id 15574420)9 Montagner A....Raynal P. (2005)
    186. Signal processing at the Ras circuit: what shapes Ras activation patterns? (PubMed id 17052120)9 Markevich N.I....Kholodenko B.N. (2004)
    187. Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP. (PubMed id 11463818)9 Yang J.Y. and Widmann C. (2001)
    188. RasGAP is involved in signal transduction triggered by FGF1 in Xenopus oocytes expressing FGFR1. (PubMed id 11356202)9 Cailliau K....Vilain J.P. (2001)
    189. Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells. (PubMed id 10490822)9 Leblanc V....Tocque B. (1999)
    190. Tyrosine phosphorylation of ras GTPase-activating protein does not require association with the epidermal growth factor receptor. (PubMed id 8408058)9 Soler C....Carpenter G. (1993)
    191. Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming ability of ras. (PubMed id 8262937)9 Eccleston J.F....Lowe P.N. (1993)
    192. Impaired Akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of RasGAP at position 157. (PubMed id 15901831)9 Yang J.Y....Widmann C. (2005)
    193. Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity. (PubMed id 10688886)9 Kashige N....Kobayashi R. (2000)
    194. A new function of p120-GTPase-activating protein. Prevention of the guanine nucleotide exchange factor-stimulated nucleotide exchange on the active form of Ha-ras p21. (PubMed id 9312123)9 Giglione C....Parmeggiani A. (1997)
    195. Activation of R-Ras GTPase by GTPase-activating proteins for Ras, Gap1(m), and p120GAP. (PubMed id 9235929)9 Li S....Hattori S. (1997)
    196. Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets. (PubMed id 1323853)9 Torti M. and Lapetina E.G. (1992)
    197. Rap1A antagonizes the ability of Ras and Ras-Gap to inhibit muscarinic K+ channels. (PubMed id 1939245)9 Yatani A....Bokoch G.M. (1991)
    198. p120 Ras GTPase-activating protein associates with fibroblast growth factor receptors in Drosophila. (PubMed id 15030317)9 Woodcock S.A. and Hughes D.A. (2004)
    199. Expression of rasGTPase activating protein in basal cell carcinoma of the skin. (PubMed id 9521474)9 Barshack I....Friedman E. (1998)
    200. Aberrant expression of p21RAS but not p120GAP is a common feature of myelodysplasia. (PubMed id 7475271)9 Gallagher A....Darley R.L. (1995)
    201. Annexin A6 inhibits Ras signalling in breast cancer cells. (PubMed id 18850003)9 VilA! de Muga S....Grewal T. (2009)
    202. A subset of caspase substrates functions as the Jekyll and Hyde of apoptosis. (PubMed id 12517717)9 Yang J.Y. and Widmann C. (2002)
    203. The arginine finger loop of yeast and human GAP is a determinant for the specificity toward Ras GTPase. (PubMed id 11412100)9 te Biesebeke R....Parmeggiani A. (2001)
    204. Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor. (PubMed id 10391888)9 DeMali K.A....Kazlauskas A. (1999)
    205. Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP binding. (PubMed id 10229199)9 Ekman S....Ronnstrand L. (1999)
    206. The Ras-GTPase-activating protein SH3 domain is required for Cdc2 activation and mos induction by oncogenic Ras in Xenopus oocytes independently of mitogen-activated protein kinase activation. (PubMed id 8649428)9 Pomerance M....Pierre M. (1996)
    207. Decreased expression of Ras GTPase activating protein in human trophoblastic tumors. (PubMed id 7747802)9 Stahle-Backdhal M....Friedman E. (1995)
    208. Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth. (PubMed id 8195713)9 Skorski T....Calabretta B. (1994)
    209. Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP. (PubMed id 8290249)9 Boyer M.J....Bar-Sagi D. (1994)
    210. Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells. (PubMed id 16314845)9 Mangoura D....Vallianatos G. (2006)
    211. Sam68 is a Ras-GAP-associated protein in mitosis. (PubMed id 9571195)9 Guitard E....Tocque B. (1998)
    212. Ras-GAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain. (PubMed id 9710640)9 Leblanc V....Delumeau I. (1998)
    213. Chemotactic peptide-induced activation of Ras in human neutrophils is associated with inhibition of p120-GAP activity. (PubMed id 9287361)9 Zheng L....Andersson T. (1997)
    214. Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. (PubMed id 8816504)9 Klinghoffer R.A....Kazlauskas A. (1996)
    215. CaLB: a 43 amino acid calcium-dependent membrane/phospholipid binding domain in p120 Ras GTPase-activating protein. (PubMed id 7898923)9 Gawler D.J....Moran M.F. (1995)
    216. Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites. (PubMed id 8036006)9 Soler C....Carpenter G. (1994)
    217. Effector domain mutations dissociate p21ras effector function and GTPase-activating protein interaction. (PubMed id 8246952)9 Stone J.C....Bottorff D. (1993)
    218. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. (PubMed id 1570015)9 Basu T.N....Downward J. (1992)
    219. Differential regulation of rasGAP and neurofibromatosis gene product activities. (PubMed id 1904555)9 Bollag G. and McCormick F. (1991)
    220. The impact of the regulatory design on the response of epidermal growth factor receptor-mediated signal transduction towards oncogenic mutations. (PubMed id 17916191)9 Wolf J....Goryanin I. (2007)
    221. Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity. (PubMed id 12486127)9 Tong J....Pawson T. (2003)
    222. Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP. (PubMed id 12787671)9 Ahmadian M.R....Scheffzek K. (2003)
    223. Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. (PubMed id 14560030)9 Agazie Y.M. and Hayman M.J. (2003)
    224. Phosphospecific antibodies reveal temporal regulation of platelet-derived growth factor beta receptor signaling. (PubMed id 10585294)9 Bernard A. and Kazlauskas A. (1999)
    225. Determinants of Ras proteins specifying the sensitivi ty to yeast Ira2p and human p120-GAP. (PubMed id 8605880)9 Parrini M.C....Parmeggiani A. (1996)
    226. [Heterogeneity of GTPase-activating proteins for Ras in the regulation of Ras signal transduction pathway] (PubMed id 8699317)9 Hattori S. and Baba H. (1996)
    227. The PH domain of Ras-GAP is sufficient for in vitro b inding to beta gamma subunits of heterotrimeric G proteins. (PubMed id 8714559)9 Xu N....Gutkind J.S. (1996)
    228. Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin. (PubMed id 7492562)9 Nixon A.E....Webb M.R. (1995)
    229. Inhibition of T-cell antigen receptor signaling by ov erexpression of p120GAP. (PubMed id 8123598)9 Baldari C.T....Telford J.L. (1994)
    230. [Are rap genes anti-oncogenes?] (PubMed id 8204955)9 de Gunzburg J. (1993)
    231. Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells. (PubMed id 1569084)9 Torti M....Lapetina E.G. (1992)
    232. Structure-based design of peptides against G3BP with cytotoxicity on tumor cells. (PubMed id 20180532)9 Cui W....Ji M. (2010)
    233. Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction. (PubMed id 19574548)9 Xu J....Epstein J.A. (2009)
    234. Solubility survey of fragments of the neurofibromatos is type 1 protein neurofibromin. (PubMed id 19111619)9 Bonneau F....Scheffzek K. (2009)
    235. Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation. (PubMed id 19261604)9 Zhou X. and Agazie Y.M. (2009)
    236. P120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling. (PubMed id 19022332)9 Pamonsinlapatham P....Raynaud F. (2009)
    237. A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling molecules. (PubMed id 17936057)9 Panasyuk G....El'skaya A.V. (2008)
    238. Genome wide analysis of pathogenic SH2 domain mutations. (PubMed id 18260110)9 Lappalainen I....Vihinen M. (2008)
    239. Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2. (PubMed id 18218617)9 Patrakitkomjorn S....Araki N. (2008)
    240. The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes. (PubMed id 17984089)9 Owen D....Mott H.R. (2008)
    241. High resolution crystal structures of the p120 RasGAP SH3 domain. (PubMed id 17188236)9 Ross B....Gajhede M. (2007)
    242. PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells. (PubMed id 17200120)9 Huang W....Eklund E.A. (2007)
    243. A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation. (PubMed id 17389760)9 Smida M....Lindquist J.A. (2007)
    244. An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development. (PubMed id 17339331)9 Modzelewska K....Moghal N. (2007)
    245. Hypophosphorylated TCR/CD3zeta signals through a Grb2-SOS1-Ras pathway in Lck knockdown cells. (PubMed id 17683112)9 Methi T....Tasken K. (2007)
    246. The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways. (PubMed id 17096025)9 Shapira S....Stein R. (2007)
    247. RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. (PubMed id 17389591)9 Zhang H....Min W. (2007)
    248. 12-O-tetradecanoyl-phorbol-13-acetate-dependent up-regulation of dopaminergic gene expression requires Ras and neurofibromin in human IMR-32 neuroblastoma. (PubMed id 16635257)9 Mangoura D....Tsirimonaki E. (2006)
    249. A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein. (PubMed id 16397625)9 D'Angelo I....Scheffzek K. (2006)
    250. Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important. (PubMed id 15640155)9 Vantler M....Rosenkranz S. (2005)
    251. The NF1 tumor suppressor critically regulates TSC2 and mTOR. (PubMed id 15937108)9 Johannessen C.M....Cichowski K. (2005)
    252. A-Raf associates with and regulates platelet-derived growth factor receptor signalling. (PubMed id 15763428)9 Mahon E.S....Anderson D.H. (2005)
    253. Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade. (PubMed id 15774489)9 Zhu Y....Zhang S. (2005)
    254. Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells. (PubMed id 15608142)9 Hiragun T....Beaven M.A. (2005)
    255. Stromal cell-derived factor-1alpha/CXCL12-induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1. (PubMed id 15345598)9 Okabe S....Broxmeyer H.E. (2005)
    256. Growth inhibition of human pancreatic cancer cells by human interferon-beta gene combined with gemcitabine. (PubMed id 15647844)9 Endou M....Yoshida J. (2005)
    257. Dimerize RACK1 upon transformation with oncogenic ras. (PubMed id 15796907)9 Chu L.Y....Chuang N.N. (2005)
    258. The importance of genome architecture in cancer susceptibility: location, location, location. (PubMed id 15492507)9 Reilly K.M. (2004)
    259. Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase. (PubMed id 14647425)9 Gerard A....Nunes J.A. (2004)
    260. Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells. (PubMed id 14654952)9 Zrihan-Licht S....Avraham H.K. (2004)
    261. The TEL/ARG leukemia oncogene promotes viability and hyperresponsiveness to hematopoietic growth factors. (PubMed id 15005341)9 Okuda K....Griffin J.D. (2004)
    262. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. (PubMed id 15340059)9 Li Y.... Guan K.-L. (2004)
    263. DNA microarray analysis of gene expression in human optic nerve head astrocytes in response to hydrostatic pressure. (PubMed id 14747662)9 Yang P....Hernandez M.R. (2004)
    264. Role of Dok-1 and Dok-2 in leukemia suppression. (PubMed id 15611295)9 Niki M....Pandolfi P.P. (2004)
    265. AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3. (PubMed id 12813029)9 Zhang R.... Min W. (2003)
    266. Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. (PubMed id 14624252)9 Tallquist M.D....Soriano P. (2003)
    267. Analysis of gene expression profiles in an imatinib-resistant cell line, KCL22/SR. (PubMed id 12743326)9 Ohmine K....Ozawa K. (2003)
    268. Organic solvents order the dynamic switch II in Ras crystals. (PubMed id 12842038)9 Buhrman G....Mattos C. (2003)
    269. VEGF receptor expression and signaling in human bladder tumors. (PubMed id 12776187)9 Wu W....Broek D. (2003)
    270. Calcium channel upregulation in response to activation of neurotrophin and surrogate neurotrophin receptor tyrosine kinases. (PubMed id 13130503)9 Black M.J....Rane S.G. (2003)
    271. A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. (PubMed id 12427839)9 Rizvi T.A....Ratner N. (2002)
    272. Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the 'French paradox'. (PubMed id 12397093)9 Rosenkranz S....BAPhm M. (2002)
    273. Coxsackievirus B3 replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway. (PubMed id 11884562)9 Luo H....McManus B.M. (2002)
    274. A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. (PubMed id 11841937)9 Shah K. and Shokat K.M. (2002)
    275. The requirement of tyrosines 579 and 581 for maximal ligand-dependent activation of the betaPDGFR is influenced by noncytoplasmic regions of the receptor. (PubMed id 11281646)9 Nickas M.E....Kazlauskas A. (2001)
    276. Human breast cancer MDA-MB-231 cells fail to express the neurofibromin protein, lack its type I mRNA isoform and show accumulation of P-MAPK and activated Ras. (PubMed id 11566491)9 Ogata H....De Luca L.M. (2001)
    277. A neurofibromatosis-1-regulated pathway is required for learning in Drosophila. (PubMed id 10706287)9 Guo H.F....Zhong Y. (2000)
    278. Engagement of the T lymphocyte antigen receptor regulates association of son-of-sevenless homologues with the SH3 domain of phospholipase Cgamma1. (PubMed id 10940929)9 Scholler J.K....Kanner S.B. (2000)
    279. Signaling of G(alpha)(12) family of G proteins through a tyrosine kinase and a Ras-GAP. (PubMed id 11239796)9 Cvejic S....Huang X. (2000)
    280. The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. (PubMed id 10755621)9 Tamir I....Cambier J.C. (2000)
    281. Characterization of Saccharomyces cerevisiae strains expressing ira1 mutant alleles modeled after disease-causing mutations in NF1. (PubMed id 10706001)9 Gil R. and Seeling J.M. (1999)
    282. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. (PubMed id 10380925)9 Fambrough D....Lander E.S. (1999)
    283. Platelet-derived growth factor-mediated signal transduction underlying astrocyte proliferation: site of ethanol action. (PubMed id 10559409)9 Luo J. and Miller M.W. (1999)
    284. Sulindac sulfide inhibits Ras signaling. (PubMed id 9778042)9 Herrmann C....Muller O. (1998)
    285. Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog. (PubMed id 9751798)9 Allen M.... Buckler A. (1998)
    286. Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1 (NF1). (PubMed id 9668168)9 Klose A....Nuernberg P. (1998)
    287. The importance of two conserved arginine residues for catalysis by the ras GTPase-activating protein, neurofibromin. (PubMed id 9545275)9 Sermon B.A....Eccleston J.F. (1998)
    288. Structural analysis of the GAP-related domain from neurofibromin and its implications. (PubMed id 9687500)9 Scheffzek K....Wittinghofer A. (1998)
    289. The OMgp gene, a second growth suppressor within the NF1 gene. (PubMed id 9569019)9 Habib A.A....Stefansson K. (1998)
    290. Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. (PubMed id 9808187)9 Jauliac S....Hivroz C. (1998)
    291. FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. (PubMed id 9697832)9 Nelms K....Paul W.E. (1998)
    292. Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor. (PubMed id 9584148)9 Chau L.A....Madrenas J. (1998)
    293. Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis. (PubMed id 9528773)9 DeMali K.A. and Kazlauskas A. (1998)
    294. Identification of phosphorylated proteins associated with the fibroblast growth factor receptor type I during early Xenopus development. (PubMed id 9535739)9 Ryan P.J....Gillespie L.L. (1998)
    295. Altered regulation of Src tyrosine kinase by transforming growth factor beta1 in a human hepatoma cell line. (PubMed id 9731575)9 Fukuda K....Matsuzawa Y. (1998)
    296. [Isoprenylated proteins and cell proliferation: regulators and effectors of Ras proteins] (PubMed id 9255347)9 de Gunzburg J. (1997)
    297. Molecular targets of CD45 in B cell antigen receptor signal transduction. (PubMed id 9013950)9 Pao L.I....Cambier J.C. (1997)
    298. p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines. (PubMed id 8808688)9 Okuda K....Griffin J.D. (1996)
    299. Mechanism of inhibition by arachidonic acid of the catalytic activity of Ras GTPase-activating proteins. (PubMed id 8576154)9 Sermon B.A....Lowe P.N. (1996)
    300. Insulin-induced tyrosine phosphorylation of a M(r) 70,000 protein revealed by association with the Src homology 2 (SH2) and SH3 domains of p120GAP and Grb2. (PubMed id 9052995)9 Medema J.P....Bos J.L. (1996)
    301. Proliferation and differentiation of PC12 cells were affected by p21ras GTPase activating proteins and its deletion mutant proteins. (PubMed id 8561792)9 Nakata H. and Watanabe Y. (1996)
    302. The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. (PubMed id 8756646)9 Brill S.... Snijders A.J. (1996)
    303. Control of ras activation. (PubMed id 8909796)9 Downward J. (1996)
    304. A conserved region of c-Ha-Ras is required for efficient GTPase stimulation by GTPase activating protein but not neurofibromin. (PubMed id 7499225)9 Yoder-Hill J....Stacey D.W. (1995)
    305. Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation. (PubMed id 7791787)9 Matoskova B....Di Fiore P.P. (1995)
    306. Calcium induces tyrosine phosphorylation of a novel p120GAP-associated protein of 65 kDa. (PubMed id 7544452)9 Medema J.P....Bos J.L. (1995)
    307. Changes in tyrosine-phosphorylated p190 and its association with p120 type I and p100 type II rasGAPs during myelomonocytic differentiation of human leukemic cells. (PubMed id 7756172)9 Cheng J.C....Clark J.W. (1995)
    308. Properties and regulation of the catalytic domain of Ira2p, a Saccharomyces cerevisiae GTPase-activating protein of Ras2p. (PubMed id 7577970)9 Parrini M.C....Parmeggiani A. (1995)
    309. Different structural requirements within the switch II region of the Ras protein for interactions with specific downstream targets. (PubMed id 7630628)9 Moodie S.A....Wolfman A. (1995)
    310. Interactions between Ras and Raf: key regulatory proteins in cellular transformation. (PubMed id 8607981)9 Marshall M. (1995)
    311. Ras-GTP regulation is not altered in cultured melanocytes with reduced levels of neurofibromin derived from patients with neurofibromatosis 1 (NF1). (PubMed id 7794530)9 Griesser J....Krone W. (1995)
    312. Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels. (PubMed id 7609078)9 Largaespada D.A....Copeland N.G. (1995)
    313. The chemotactic response to PDGF-BB: evidence of a role for Ras. (PubMed id 7622571)9 Kundra V....Zetter B.R. (1995)

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    Entrez Gene: 5921 HGNC: 9871 AceView: RASA1 Ensembl:ENSG00000145715 euGenes: HUgn5921
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