Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RASA1 Gene

protein-coding   GIFtS: 70
GCID: GC05P086565

RAS P21 Protein Activator (GTPase Activating Protein) 1


(Previous symbol: RASA)
  See RASA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RAS P21 Protein Activator (GTPase Activating Protein) 11 2     RASGAP2
RASA1 2 3     p120RASGAP2
GAP2 3 5     Ras GTPase-Activating Protein 12
p120GAP2 3     Triphosphatase-Activating Protein2
CMAVM2 5     RasGAP3
PKWS2 5     GTPase-Activating Protein3
Capillary Malformation-Arteriovenous Malformation1     Ras P21 Protein Activator3
CM-AVM2     

External Ids:    HGNC: 98711   Entrez Gene: 59212   Ensembl: ENSG000001457157   OMIM: 1391505   UniProtKB: P209363   

Export aliases for RASA1 gene to outside databases

Previous GC identifers: GC05P085479 GC05P086779 GC05P086602 GC05P086648 GC05P086599 GC05P081768


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RASA1 Gene:
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating
proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart.
Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins
resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and
differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal
cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without
arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where
the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be
abundantly expressed in placental but not adult tissues. (provided by RefSeq, May 2012)

GeneCards Summary for RASA1 Gene:
RASA1 (RAS p21 protein activator (GTPase activating protein) 1) is a protein-coding gene. Diseases associated with RASA1 include parkes weber syndrome, rasa1-related, and rasa1-related disorders. GO annotations related to this gene include phospholipid binding and glycoprotein binding. An important paralog of this gene is SYNGAP1.

UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936
Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic
Ras p21; this stimulation may be further increased in the presence of NCK1

Gene Wiki entry for RASA1 (RAS p21 protein activator 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the RASA1 gene promoter:
         PPAR-gamma1   NF-1/L   NF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RASA1 promoter sequence
   Search Chromatin IP Primers for RASA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3   Ensembl cytogenetic band:  5q14.3   HGNC cytogenetic band: 5q13

RASA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RASA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P086565:  view genomic region     (about GC identifiers)

Start:
86,563,705 bp from pter      End:
86,687,748 bp from pter
Size:
124,044 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936 (See protein sequence)
Recommended Name: Ras GTPase-activating protein 1  
Size: 1047 amino acids; 116403 Da
Subunit: Interacts with SQSTM1. Interacts with SPSB1; the interaction does not promote degradation. Interacts with
CAV2 (tyrosine phosphorylated form). Directly interacts with NCK1. Interacts with PDGFRB (tyrosine
phosphorylated). Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1
Selected PDB 3D structures from and Proteopedia for RASA1 (see all 8):
1WER (3D)        1WQ1 (3D)        2GQI (3D)        2GSB (3D)        2J05 (3D)        2J06 (3D)    
Secondary accessions: B2R6W3 Q9UDI1
Alternative splicing: 2 isoforms:  P20936-1   P20936-2   

Explore the universe of human proteins at neXtProt for RASA1: NX_P20936

Explore proteomics data for RASA1 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity,
    whereas phosphorylation by LCK does not display any effect on stimulation activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RASA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002881.1  NP_072179.1  

    ENSEMBL proteins: 
     ENSP00000274376   ENSP00000423395   ENSP00000411221   ENSP00000422008   ENSP00000420905  
    Reactome Protein details: P20936

    RASA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RASA1
    OriGene Protein Over-expression Lysate for RASA1
    OriGene MassSpec for RASA1
    OriGene Custom Protein Services for RASA1
    GenScript Custom Purified and Recombinant Proteins Services for RASA1
    Novus Biologicals RASA1 Proteins
    Novus Biologicals RASA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RASA1

     
    Search eBioscience for Proteins for RASA1 

    RASA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RASA1
    R&D Systems Antibodies for RASA1 (Ras-GAP)
    OriGene Antibodies for RASA1
    OriGene Custom Antibody Services for RASA1
    Novus Biologicals RASA1 Antibodies
    Abcam antibodies for RASA1
    Cloud-Clone Corp. Antibodies for RASA1
    ThermoFisher Antibody for RASA1
    LSBio Antibodies in human, mouse, rat for RASA1

    RASA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RASA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RASA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RASA1
    Cloud-Clone Corp. CLIAs for RASA1
    Search eBioscience for ELISAs for RASA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing

    Selected InterPro protein domains (see all 9):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry P20936

    ProtoNet protein and cluster: P20936

    5 Blocks protein domains:
    IPB000008 C2 domain
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain
    Similarity: Contains 2 SH2 domains
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with RASA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASA1_HUMAN, P20936
    Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic
    Ras p21; this stimulation may be further increased in the presence of NCK1

         Genatlas biochemistry entry for RASA1:
    Ras-p21 GTPase-activating protein,120kDa,GAP,involved in normal blood vessel development

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IPI8618896
    GO:0005096GTPase activator activity ----
    GO:0005099Ras GTPase activator activity IBA--
    GO:0005102receptor binding IPI2157284
    GO:0005515protein binding IPI1314164
         
    Find genes that share ontologies with RASA1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RASA1:
     Decreased cell number and incr  Increased cell death HMECs cel 

         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rasa1):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  hearing/vestibular/ear  immune system  limbs/digits/tail  mortality/aging 
     muscle  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with RASA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rasa1tm1Paw for RASA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RASA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RASA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RASA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RASA1:
    hsa-mir-214-3p (MIRT024963), hsa-mir-92a-3p (MIRT049006), hsa-mir-335-5p (MIRT003230), hsa-mir-26a-5p (MIRT050067), hsa-mir-30c-5p (MIRT047898), hsa-mir-132-3p (MIRT007010), hsa-mir-31-5p (MIRT007292)

    Block miRNA regulation of human, mouse, rat RASA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASA1 (see all 40):
    hsa-miR-30d hsa-miR-301a hsa-miR-223 hsa-miR-30a hsa-miR-130b hsa-miR-4257 hsa-miR-301b hsa-miR-499-3p
    SwitchGear 3'UTR luciferase reporter plasmidRASA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RASA1
    Predesigned siRNA for gene silencing in human, mouse, rat RASA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RASA1

    Clone
    Products:
         
    OriGene clones in human, mouse for RASA1 (see all 11)
    OriGene ORF clones in mouse, rat for RASA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RASA1 (NM_022650)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RASA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RASA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RASA1_HUMAN, P20936: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane3
    cytoskeleton2
    endoplasmic reticulum1
    endosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005622intracellular ----
    GO:0005737cytoplasm NAS2821624
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ----

    Find genes that share ontologies with RASA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RASA1 About   (see all 45)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response IL 23 signaling pathway
    Development Angiopoietin Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    Angiopoietin-TIE2 Signaling0.36
    2Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    GDNF-Family Ligands and Receptor Interactions0.41
    Development GDNF family signaling0.45
    EGF Pathway0.39
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4Development EPO induced Jak STAT pathway
    Development EPO induced Jak STAT pathway0.42
    EPO Receptor Signaling0.42
    5Development HGF signaling pathway
    Development EGFR signaling via small GTPases0.44
    Signaling of Hepatocyte Growth Factor Receptor0.35


    Find genes that share SuperPaths with RASA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RASA1 (see all 14)
        Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling
    G12-G13 in Cellular Signaling
    GDNF-Family Ligands and Receptor Interactions

    Selected GeneGo (Thomson Reuters) Pathways for RASA1 (see all 15)
        G-protein signaling H-RAS regulation pathway
    G-protein signaling M-RAS regulation pathway
    Development VEGF signaling via VEGFR2 - generic cascades
    Development EGFR signaling pathway
    Development EGFR signaling via small GTPases

    Selected BioSystems Pathways for RASA1 (see all 23)
        MAPK signaling pathway
    EGFR1 Signaling Pathway
    EPO Receptor Signaling
    IL-4 signaling Pathway
    Kit Receptor Signaling Pathway

    1 Reactome Pathway for RASA1
        Downstream signal transduction


    3 Kegg Pathways  (Kegg details for RASA1):
        MAPK signaling pathway
    Ras signaling pathway
    Axon guidance

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RASA1 (see all 6): 
              Angiogenic Growth Factors in human mouse rat
              Telomeres & Telomerase in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RASA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RASA1 (P209361, 2, 3 ENSP000002743764) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-1026476,EBI-641062 MINT-74698 MINT-74702 MINT-74697 MINT-74701 MINT-74699 MINT-74712 MINT-74700 I2D: score=2 STRING: ENSP00000269571
    EGFRP005331, 2, 3, ENSP000002754934EBI-1026476,EBI-297353 MINT-74692 MINT-74711 MINT-74695 MINT-74710 MINT-74693 MINT-74694 MINT-74696 I2D: score=5 STRING: ENSP00000275493
    PDGFRBP096191, 2, 3, ENSP000002617994EBI-1026476,EBI-641237 MINT-8026988 MINT-8026958 MINT-8026973 I2D: score=5 STRING: ENSP00000261799
    CAPNS1P046321, 2, 3, ENSP000002465334EBI-1026476,EBI-711828 MINT-7304956 MINT-7304983 MINT-7304902 I2D: score=1 STRING: ENSP00000246533
    ABI1Q8IZP01, 2, 3, ENSP000003653124EBI-1026476,EBI-375446 MINT-7908187 MINT-7908586 I2D: score=1 STRING: ENSP00000365312
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis ISS--
    GO:0001570vasculogenesis ISS--
    GO:0001953negative regulation of cell-matrix adhesion IDA8344248
    GO:0007162negative regulation of cell adhesion IDA8344248
    GO:0007165signal transduction IDA1756860

    Find genes that share ontologies with RASA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for RASA1
      Browse compounds at ApexBio 

    Browse Tocris compounds for RASA1

    Selected Novoseek inferred chemical compound relationships for RASA1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 72.9 21 9312123 (3), 8262937 (2), 7492562 (1), 8607981 (1) (see all 15)
    tyrosine 69.4 76 10567236 (5), 10688886 (4), 8408058 (3), 15030317 (2) (see all 39)
    gdp 58.1 5 17052120 (1), 8909796 (1), 9312123 (1), 15774489 (1)
    phosphotyrosine 53.4 3 15030317 (1), 10391888 (1)
    guanine 27.4 1 7622571 (1)
    phosphatidylinositol 26.3 4 1328986 (1), 7898923 (1), 15763428 (1), 8816504 (1)
    arginine 22.4 8 11412100 (3), 15340059 (2), 9668168 (1)
    guanosine 12.3 2 9731575 (1)
    phenylalanine 6.07 1 8408058 (1)
    serine 3.17 1 16314845 (1)



    Find genes that share compounds with RASA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RASA1 gene (2 alternative transcripts): 
    NM_002890.2  NM_022650.2  

    Unigene Cluster for RASA1:

    RAS p21 protein activator (GTPase activating protein) 1
    Hs.664080  [show with all ESTs]
    Unigene Representative Sequence: CR749722
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274376 ENST00000515800(uc003kiw.3 uc010jav.3) ENST00000456692(uc003kix.3 uc011ctv.2 uc011ctw.2 uc010jaw.3)
    ENST00000512763 ENST00000506290 ENST00000509953
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RASA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RASA1 (see all 40):
    hsa-miR-30d hsa-miR-301a hsa-miR-223 hsa-miR-30a hsa-miR-130b hsa-miR-4257 hsa-miR-301b hsa-miR-499-3p
    SwitchGear 3'UTR luciferase reporter plasmidRASA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RASA1
    Predesigned siRNA for gene silencing in human, mouse, rat RASA1
    Clone
    Products:
         
    OriGene clones in human, mouse for RASA1 (see all 11)
    OriGene ORF clones in mouse, rat for RASA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see first 1): RASA1 (NM_022650  NM_002890)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RASA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASA1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RASA1
    OriGene qSTAR qPCR primer pairs in human, mouse for RASA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASA1
      QuantiTect SYBR Green Assays in human, mouse, rat RASA1
      QuantiFast Probe-based Assays in human, mouse, rat RASA1

    Additional mRNA sequence: 

    AB209106.1 AK300263.1 AK300269.1 AK300406.1 AK312739.1 BC020761.1 BC033015.2 BC054891.1 
    BC070063.1 BC107870.1 BC131816.1 CR749722.1 M23379.1 M23612.1 

    Selected DOTS entries (see all 36):

    DT.92454258  DT.100833161  DT.92454256  DT.92454259  DT.100689204  DT.120829242  DT.421222  DT.75191555 
    DT.92454254  DT.95186287  DT.97820076  DT.40260770  DT.436627  DT.40226058  DT.95186278  DT.75146302 
    DT.40198236  DT.91657462  DT.95186275  DT.95186306  DT.95186310  DT.100786289  DT.120829251  DT.120829312 

    Selected AceView cDNA sequences (see all 282):

    BM455842 BM906274 BF589794 NM_022650 AA872525 BQ009691 AU135369 AA251808 
    CF528258 BE501681 AU136375 AU138236 NM_002890 AU136473 BC070063 AU137957 
    H99046 AU135843 AW192176 AU138673 CD172265 AI611854 AA301373 BG621389 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RASA1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RASA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RASA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACCCATTC
    RASA1 Expression
    About this image

    RASA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RASA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.664080

    UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936
    Tissue specificity: In placental villi, detected only in the trophoblast layer (cytotrophoblast and
    syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RASA1 (see all 6): 
              Angiogenic Growth Factors in human mouse rat
              Telomeres & Telomerase in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RASA1
    OriGene qSTAR qPCR primer pairs in human, mouse for RASA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASA1
    QuantiTect SYBR Green Assays in human, mouse, rat RASA1
    QuantiFast Probe-based Assays in human, mouse, rat RASA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RASA1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rasa11 , 5 RAS p21 protein activator 11, 5 90.75(n)1
    94.99(a)1
      13 (45.05 cM)5
    2183971  NM_145452.31  NP_663427.21 
     852147805 
    chicken
    (Gallus gallus)
    Aves RASA11 RAS p21 protein activator (GTPase activating protein) more 84.84(n)
    93.77(a)
      427327  XM_424907.4  XP_424907.4 
    lizard
    (Anolis carolinensis)
    Reptilia RASA16
    RAS p21 protein activator (GTPase activating prote...
    84(a)
    1 ↔ 1
    2(20823673-20889265)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.285652 Xenopus laevis transcribed sequence with strong similarity more 80.71(n)    BI314837.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF347677.12   -- 77.34(n)    CF347677.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vap1 , 3 RAS GTPase activator3
    vacuolar peduncle1
    46(a)3
    52.41(n)1
    48.85(a)1
      325691  NM_167481.21  NP_727926.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BUD26
    GTPase activating factor for Rsr1p/Bud1p required ...
    13(a)
    1 → many
    XI(266145-269459) YKL092C


    ENSEMBL Gene Tree for RASA1 (if available)
    TreeFam Gene Tree for RASA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RASA1 gene
    SYNGAP12  DAB2IP2  RASA42  RASAL32  RASA22  RASA4B2  RASAL22  RASA32  
    RASAL12  
    4 SIMAP similar genes for RASA1 using alignment to 5 protein entries:     RASA1_HUMAN (see all proteins):
    DKFZp434N071    PTPN11    GRAP2    GRAPL

    Find genes that share paralogs with RASA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RASA1 (see all 2132)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0177444
    Capillary malformation-arteriovenous malformation (CMAVM)4--see VAR_0177442 C Y mis40--------
    VAR_0026504
    Basal cell carcinomas4--see VAR_0026502 R L mis40--------
    VAR_0026524
    Basal cell carcinomas4--see VAR_0026522 I V mis40--------
    VAR_0026514
    Basal cell carcinomas4--see VAR_0026512 K E mis40--------
    rs38405221,2
    C--86563775(+) CCCCA-/ACCCCT 2 -- us2k10--------
    rs1998827181,2
    C--86576743(+) TTTTT-/TGAGGC 2 -- int10--------
    rs2004615111,2
    C--86578965(+) TTTTT-/TGGTTG 2 -- int10--------
    rs342170121,2
    C--86580850(+) GTACCATTT/-  
            
    ATTTA
    2 -- int11Minor allele frequency- -:0.50NA 2
    rs1113042951,2
    F--86582667(+) ATATAC/TACACC 2 -- int12Minor allele frequency- T:0.33CSA 3
    rs623689401,2
    --86583849(+) ATATAC/TATATA 2 -- int10--------

    HapMap Linkage Disequilibrium report for RASA1 (86563705 - 86687748 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RASA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv327831CNV Loss16902084
    nsv830379CNV Gain17160897

    Human Gene Mutation Database (HGMD): RASA1
    Locus Specific Mutation Databases (LSDB): RASA1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RASA1
    DNA2.0 Custom Variant and Variant Library Synthesis for RASA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 139150   
    OMIM disorders: 608355  608354  605462  
    UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936
  • Note=Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas
  • Capillary malformation-arteriovenous malformation (CMAVM) [MIM:608354]: A disorder characterized by
    atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These
    capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes
    Weber syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Parkes Weber syndrome (PKWS) [MIM:608355]: Disorder characterized by a cutaneous flush with underlying
    multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected
    limb. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 12 diseases for RASA1:    
    About MalaCards
    parkes weber syndrome, rasa1-related    rasa1-related disorders    basal cell carcinoma, somatic    arteriovenous malformation
    vein of galen aneurysm    capillary malformation-arteriovenous malformation syndrome    parkes weber syndrome    weber syndrome
    sturge-weber syndrome    basal cell carcinoma    neurofibromatosis    klippel-trenaunay syndrome

    3 diseases from the University of Copenhagen DISEASES database for RASA1:
    Neurofibromatosis     Klippel-Trenaunay syndrome     Arteriovenous malformation

    Find genes that share disorders with RASA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RASA1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibromatosis type 1 75.4 6 1620552 (1), 8246952 (1), 17096025 (1), 18218617 (1) (see all 6)
    trophoblastic tumor 47.5 4 7747802 (2), 8738474 (1)
    myeloid leukemia chronic 37.7 1 1571536 (1)
    neurofibromatosis 37.3 2 1904555 (2)
    choriocarcinoma 27.4 2 7747802 (1)
    multiple tumors 22.6 1 9521474 (1)
    tumors 14.2 20 9521474 (3), 8738474 (3), 17096025 (1), 1368795 (1) (see all 13)
    necrosis 4.41 1 17389591 (1)
    carcinoma basal cell 3.87 2 9521474 (1), 8738474 (1)
    cancer 1.65 1 17096025 (1)

    Genetic Association Database (GAD): RASA1
    Human Genome Epidemiology (HuGE) Navigator: RASA1 (14 documents)

    Export disorders for RASA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RASA1 gene, integrated from 10 sources (see all 334):
    (articles sorted by number of sources associating them with RASA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations. (PubMed id 14639529)1, 2, 9 Eerola I.... Vikkula M. (Am. J. Hum. Genet. 2003)
    2. Purification, characterization, and cellular localization of the 100- kDa human placental GTPase-activating protein. (PubMed id 8360177)1, 2, 9 Zhang Y....Thane M.N. (J. Biol. Chem. 1993)
    3. Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27). (PubMed id 15504032)1, 2, 9 Wang X.B.... Lisanti M.P. (Biochemistry 2004)
    4. Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho- caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. (PubMed id 12091389)1, 2, 9 Lee H....Lisanti M.P. (J. Biol. Chem. 2002)
    5. Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm. (PubMed id 11389730)1, 2, 9 Giglione C.... Parmeggiani A. (Eur. J. Biochem. 2001)
    6. Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity. (PubMed id 21664272)1, 2 Ger M.... Valius M. (Cell. Signal. 2011)
    7. High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine. (PubMed id 20592250)1, 4 Bachas C....Cloos J. (Blood 2010)
    8. Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas. (PubMed id 20702649)1, 4 Hemerly J.P....Cerutti J.M. (Eur. J. Endocrinol. 2010)
    9. Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia. (PubMed id 20688547)1, 4 Wiemels J.L....Wiencke J.K. (amp 2010)
    10. Genome wide molecular analysis of minimally differentiated acute myeloid leukemia. (PubMed id 19773259)1, 4 Silva F.P....Giphart-Gassler M. (Haematologica 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5921 HGNC: 9871 AceView: RASA1 Ensembl:ENSG00000145715 euGenes: HUgn5921
    ECgene: RASA1 Kegg: 5921 H-InvDB: RASA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RASA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RASA1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=RASA1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RASA1 gene:
    Search GeneIP for patents involving RASA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RASA1
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for RASA1 (Ras-GAP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RASA1   OriGene RNAi products in human, mouse, rat for RASA1  
     OriGene qPCR primer pairs and template standards for RASA1   OriGene Protein Over-expression Lysate for RASA1  
     OriGene MassSpec something-or-other for RASA1   OriGene clones in human, mouse for RASA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RASA1   OriGene Purified Protein for RASA1  
     OriGene ORF clones in mouse, rat for RASA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RASA1   OriGene Custom Protein Services for RASA1  

     
     
     Block miRNA regulation of human, mouse, rat RASA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RASA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RASA1 Predesigned siRNA for gene silencing in human, mouse, rat RASA1
     QuantiFast Probe-based Assays in human, mouse, rat RASA1 QuantiTect SYBR Green Assays in human, mouse, rat RASA1
     PCR Arrays including human, mouse, rat RASA1 Search Chromatin IP Primers for RASA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RASA1  GeneGlobe Interaction Network for RASA1
     Regulatory tfbs in RASA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RASA1 GenScript cDNA clones with any tag delivered in your preferred vector for RASA1
     GenScript Custom Assay Services for RASA1 GenScript Custom overexpressing Cell Line Services for RASA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RASA1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for RASA1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RASA1 antibodies
     RASA1 proteins
     RASA1 lysates
     Antibodies for RASA1
     See all of Abcam's Antibodies, Kits and Proteins for RASA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RASA1
     Antibodies for RASA1
     ELISAs for RASA1
     CLIAs for RASA1



     Browse ESI BIO Cell Lines and PureStem Progenitors for RASA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RASA1
     SwitchGear 3'UTR luciferase reporter plasmids for RASA1
     SwitchGear Promoter luciferase reporter plasmids for RASA1
     ThermoFisher Antibody for RASA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RASA1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RASA1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RASA1
     LSBio Antibodies in human, mouse, rat for RASA1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RASA1
      Search eBioscience for proteins for RASA1
      Search eBioscience for elisas for RASA1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RASA1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4