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RASA1 Gene

protein-coding GIFtS: 71

GC05P086599

RAS p21 protein activator (GTPase activating protein) 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RASA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CM-AVM ^¹, ²
CMAVM ^², ⁵
DKFZp434N071 ^²
GAP ^¹, ², ³, ⁵
PKWS ^², ⁵
RASA ^², ³
RASGAP ^²
RasGAP ^³
p120GAP ^¹, ², ³
p120RASGAP ^¹, ²

Descriptions
GTPase-activating protein ^³
RAS p21 protein activator (GTPase activating protein) 1 ^²
RAS p21 protein activator 1 ^²
Ras p21 protein activator ^³
triphosphatase-activating protein ^²

External Ids
HGNC: 9871¹
Entrez Gene: 5921²
UniProtKB: P20936³
Ensembl: ENSG00000145715⁷

Search outside databases for aliases for RASA1 gene

Previous GC identifers: GC05P085479 GC05P086779 GC05P086602 GC05P086648

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RASA1:

The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of

GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but

not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the

weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS,

thereby allowing control of cellular proliferation and differentiation. Mutations leading to

changes in the binding sites of either protein are associated with basal cell carcinomas.

Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal

hydrophobic region but retaining the same activity, appears to be abundantly expressed in

placental but not adult tissues. [provided by RefSeq]

UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936

Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but

not oncogenic Ras p21

Gene Wiki entry for RASA1 (RAS_p21_protein_activator_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RASA1 gene

Entrez Gene cytogenetic band: 5q13.3 Ensembl cytogenetic band: 5q14.3 HGNC cytogenetic band: 5q13

RASA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P086599: (about GC identifiers)

Start:	86,599,838 bp from pter
End:	86,723,489 bp from pter
Size:	123,652 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_006713.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936 (See protein sequence)

Recommended Name: Ras GTPase-activating protein 1

Size: 1047 amino acids; 116403 Da

Subunit: Interacts with SQTSM1. Interacts with SPSB1. Interaction with SPSB1 does not promote

degradation

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

1WER (3D)

1WQ1 (3D)

2GQI (3D)

2GSB (3D)

2J05 (3D)

2J06 (3D)

Secondary accessions: B2R6W3

Alternative splicing: 2 isoforms: P20936-1 P20936-2

Post-translational modifications:

The N-terminus is blocked¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002881.1 NP_072179.1

ENSEMBL proteins:

ENSP00000373926 ENSP00000274376

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GAP)
	Human Recombinant Proteins from Abnova (RASA1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IEA	--
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	NAS	2821624
GO:0005886	plasma membrane	IEA	--

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Antibodies for RASA1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of RASA1
	Sigma-Aldrich Antibodies for RASA1
	R&D Systems Antibodies for RASA1 (Ras-GAP)
	Antibodies from Abcam (GAP), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RASA1)
	Novus Biologicals Antibodies for RASA1

Assays for RASA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P20936

ProtoNet protein and cluster: P20936

5 Blocks protein families:

IPB000008 C2 domain

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB001849 Pleckstrin-like

IPB001936 Ras GTPase-activating protein

UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936

Similarity: Contains 1 C2 domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 Ras-GAP domain

Similarity: Contains 2 SH2 domains

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RASA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RASA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002890

Applied Biosystems Silencer® siRNAs for RASA1

Sigma-Aldrich siRNA and siRNA Panels for RASA1

Sigma-Aldrich shRNA Panels and shRNA for RASA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002890
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002890
untagged cDNA clones in CMV expression vector (see all 2): NM_002890

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002890

UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936

Function: Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but

not oncogenic Ras p21

Genatlas biochemistry entry for RASA1:

Ras-p21 GTPase-activating protein,120kDa,GAP,involved in normal blood vessel development

10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rasa1):

	cellular	craniofacial	embryogenesis	growth/size
hearing/vestibular/ear	lethality-prenatal/perinatal	limbs/digits/tail	nervous system	no phenotypic analysis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005099	Ras GTPase activator activity	TAS	2188736
GO:0005102	receptor binding	IPI	2157284 2176151
GO:0019870	potassium channel inhibitor activity	NAS	1553544
GO:0051020	GTPase binding	IPI	2122974

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/10 Sigma-Aldrich "Your Favorite Gene" Pathways for RASA1 (Your Favorite Gene powered by Ingenuity) (see all 10 )

PDGF Signaling
Angiopoietin Signaling
Huntington's Disease Signaling
IGF-1 Signaling
Axonal Guidance Signaling

GeneDecks RASA1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RASA1

5/6 Interacting proteins for RASA1 (P20936^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 6 )
Interactant Interaction Details
GeneCard External ID(s)
HRAS P01112¹ EBI-1026476, EBI-350145
EGFR P00533² MINT-74692 MINT-74711 MINT-74695 MINT-74710 MINT-74693 MINT-74694 MINT-74696
ERBB2 P04626² MINT-74698 MINT-74702 MINT-74697 MINT-74701 MINT-74699 MINT-74712 MINT-74700
ERBB3 P21860² MINT-74704 MINT-74708 MINT-74705 MINT-74707 MINT-74703 MINT-74706
ERBB4 Q15303² MINT-74709
About this table
5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis ISS --
GO:0001570 vasculogenesis ISS --
GO:0001953 negative regulation of cell-matrix adhesion IDA 8344248
GO:0007162 negative regulation of cell adhesion IDA 8344248
GO:0007242 intracellular signaling cascade NAS 1581965
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RASA1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RASA1
9 Novoseek chemical compound relationships for RASA1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	73.32	21	9312123 (3), 8262937 (2), 7492562 (1), 8607981 (1) (see all 15)
tyrosine	69.64	76	10567236 (5), 10688886 (4), 8408058 (3), 15030317 (2) (see all 39)
gdp	58.93	5	17052120 (1), 8909796 (1), 9312123 (1), 15774489 (1)
phosphotyrosine	53.97	3	15030317 (1), 10391888 (1)
phosphatidylinositol	27.30	4	1328986 (1), 7898923 (1), 15763428 (1), 8816504 (1)
guanosine	13.41	2	9731575 (1)
phenylalanine	0.00	1	8408058 (1)
calcium	0.00	4	7898923 (2), 13130503 (1)
arachidonic acid	0.00	1	8576154 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RASA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RASA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002890

Sigma-Aldrich siRNA and siRNA Panels for RASA1

Sigma-Aldrich shRNA Panels and shRNA for RASA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002890 NM_022650

REFSEQ mRNAs for RASA1 gene (2 alternative transcripts):

NM_002890.1 NM_022650.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002890 NM_022650

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002890
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002890
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002890

Additional cDNA sequence:

AB209106.1 AK300263.1 AK300269.1 AK300406.1 AK312739.1 BC020761.1 BC033015.2 BC054891.1

BC070063.1 BC107870.1 BC131816.1 CR749722.1 M23379.1 M23612.1

24/40 DOTS entries (see all 40 ):

DT.92454258 DT.100833161 DT.92454256 DT.92454259 DT.100689204 DT.120829242 DT.421222 DT.40260770

DT.40226058 DT.75191555 DT.92454254 DT.97827247 DT.95186287 DT.436627 DT.97820076 DT.91657462

DT.95186278 DT.40125559 DT.75146302 DT.120829324 DT.202851 DT.40198236 DT.40299930 DT.95186275

24/282 AceView cDNA sequences (see all 282 ):

AU137822 N77649 AA363601 AU136635 CF528258 AU136375 AA251808 NM_002890

BX503514 CD172265 AU138673 BQ232939 AU136583 BE501681 BC070063 AI611854

AU135896 AL044995 BQ007115 BM906274 AU139436 BM846040 R71077 BX475533

highest scoring ESTs for RASA1:

M23379 AA040060 AA040093 AA084398 AA167370 AA251808 AA737694 AA742586 AA873142 AI095841

Unigene Cluster for RASA1:

RAS p21 protein activator (GTPase activating protein) 1

Hs.664080 [show with all ESTs]

Unigene Representative Sequence: CR749722

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RASA1 (see all 11 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17a	·	17b	^	18a	·	18b	^	19	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	20	^	21	^	22	^	23a	·	23b	·	23c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for RASA1

2 Ensembl transcripts including schematic representations:

ENST00000389275 ENST00000274376

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RASA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RASA1

¹ / ² / ³

6 probe-sets matching RASA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36935_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.96	M23379	1.00	1.00	1.00	1
1675_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.04	M23379	1.00	1.00	1.00	1
210621_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M23612	0.80	1.00	0.91	1
202677_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002890	0.60	1.00	0.82	1
210621_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202677_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTACCCATTC

SOURCE GeneReport for Unigene cluster: Hs.664080
Expression variation in blood from EXPOLDB for RASA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RASA1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RASA1¹	--	RAS p21 protein activator (GTPase activating protein) more	92.6(n) 95.99(a)	479158 XM_536302.2 XP_536302.2
chimpanzee (Pan troglodytes)	RASA1¹	--	RAS p21 protein activator (GTPase activating protein) more	99.68(n) 99.71(a)	461762 XM_517663.2 XP_517663.2
cow (Bos taurus)	RASA1¹	--	RAS p21 protein activator (GTPase activating protein) more	93.19(n) 96.07(a)	282032 NM_174449.2 NP_776874.1
rat (Rattus norvegicus)	Rasa1¹	--	RAS p21 protein activator (GTPase activating protein) more	91.91(n) 96.05(a)	25676 NM_013135.1 NP_037267.1
mouse (Mus musculus)	Rasa1^{1, 5}	13 (47.00 cM)⁵	RAS p21 protein activator 1^{1, 5}	93.77(n)¹ 98.89(a)¹	218397¹ NM_145452.2¹ NP_663427.1¹ AA120502⁵ AA124924⁵ (see all 22)

About this table Species with no ortholog for RASA1

ENSEMBL Gene Tree for RASA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RASA1 gene

RASA2² RASA3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/376 NCBI SNPs in RASA1 are shown (see all 376 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 134)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11955528^1,2	C,F,H	86598446(+)	`GGAAGC/TTCCCT`	1	--	ng5¹		4		EU EA WA	418
	rs16876684^1,2	F,H	86599726(+)	`AGTTTT/GCGCTT`	2	--	ng5¹		7		NA EU EA WA	562
--	rs6879293^1,2	A	86723879(+)	`GCTTAA/GTAGTT`	2	--	ng3¹		0	--	--	--	--
	rs3806934^1,2	H	86599310(+)	`TCCCTC/GTGGAC`	2	--	ng5¹ trp³		4		EU EA WA	418
	rs3806935^1,2	H	86599707(+)	`CTCTTT/CAGTGC`	2	--	ng5¹ ese³ trp³		4		EU EA WA	418
	rs3747704^1,2	F	86722379(+)	`ACGTAT/CTGAAA`	2	L/L	syn¹		1		EA	1496
	rs10942503^1,2	A,C,F,H	86716684(+)	`TTTAAT/CTCAAG`	2	--	int¹		7		NA EU EA WA	560
	rs13362486^1,2	A,C,F,H	86639581(+)	`TCTTTC/ACTTAG`	2	--	int¹		8		EU EA WA NA	632
	rs11745338^1,2	A,C,F,H	86656288(+)	`GAATAC/GCTAAT`	2	--	int¹		12		EA NA EU WA	1022
	rs10059102^1,2	A,C,F,H	86624084(+)	`tgttcT/Cgttcc`	2	--	int¹		8		EU EA WA	838

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HapMap Linkage Disequilibrium images for RASA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 139150

UniProtKB/Swiss-Prot: RASA1_HUMAN, P20936

Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas

Defects in RASA1 are the cause of capillary malformation-arteriovenous malformation

(CMAVM) [MIM:608354]. CMAVM is a disorder characterized by atypical capillary malformations that

are multiple, small, round to oval in shape and pinkish red in color. These capillary

malformations are associated with either arteriovenous malformation, arteriovenous fistula, or

Parkes Weber syndrome

Defects in RASA1 are a cause of Parkes Weber syndrome (PKWS) [MIM:608355]. PKWS is a

disorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas,

in association with soft tissue and skeletal hypertrophy of the affected limb

10/12 Novoseek disease relationships for RASA1 gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neurofibromatosis type 1	75.43	6	1620552 (1), 8246952 (1), 17096025 (1), 18218617 (1) (see all 6)
trophoblastic tumor	48.60	4	7747802 (2), 8738474 (1)
myeloid leukemia chronic	38.83	1	1571536 (1)
neurofibromatosis	38.37	2	1904555 (2)
choriocarcinoma	28.32	2	7747802 (1)
multiple tumors	23.92	1	9521474 (1)
tumors	14.34	20	9521474 (3), 8738474 (3), 17096025 (1), 1368795 (1) (see all 13)
carcinoma basal cell	5.32	2	9521474 (1), 8738474 (1)
necrosis	4.36	1	17389591 (1)
cancer	0.00	1	17096025 (1)

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1 PharmGKB disease relationship for RASA1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

Human Gene Mutation Database: RASA1
Human Genome Epidemiology Navigator: RASA1 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/278 PubMed articles for RASA1 gene (see all 278 ):

Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations. (PubMed id 14639529)^{1, 3, 4} Eerola I.... Vikkula M. (2003)
Purification, characterization, and cellular localization of the 100- kDa human placental GTPase-activating protein. (PubMed id 8360177)^{1, 3, 4} Zhang Y....Thane M.N. (1993)
The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PubMed id 15713673)^{3, 4} Wang D....Wu G. (2005)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
RASA1: variable phenotype with capillary and arteriovenous malformations. (PubMed id 15917201)^{2, 3} Boon L.M....Vikkula M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. (PubMed id 9219684)^{3, 4} Scheffzek K.... Wittinghofer A. (1997)
Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras. (PubMed id 8955277)^{3, 4} Scheffzek K....Wittinghofer A. (1996)
Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region. (PubMed id 8618896)^{3, 4} Park I.... Shin J. (1995)
Solution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence. (PubMed id 8137811)^{3, 4} Yang Y.S.... Roques B.P. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5921	HGNC: 9871	AceView: RASA1	Ensembl:ENSG00000145715	euGenes: HUgn5921
ECgene: RASA1	H-InvDB: RASA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RASA1	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=RASA1

Licensable Technologies for RASA1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RASA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RASA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RASA1		Antibodies for RASA1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RASA1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RASA1)
	Antibodies (RASA1)
	Chimera RNAi (RASA1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (GAP)
	Antibodies (GAP)

Search OriGene for RASA1

Search Tocris compounds for RASA1

	Drugs for RASA1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RASA1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
RASA1 Gene at Home site.
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RASA1 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for RASA1

Summaries
for RASA1

Genomic Location
for RASA1

Proteins
for RASA1

Protein Domains/
Families
for RASA1

Gene Function
for RASA1

Pathways & Interactions
for RASA1

Drugs & Compounds
for RASA1

Transcripts
for RASA1

Expression
for RASA1

Orthologs
for RASA1

Paralogs
for RASA1

SNPs/Variants
for RASA1

Disorders & Mutations
for RASA1

Medical News
for RASA1

Publications
for RASA1

Search for RASA1

Genome Databases showing RASA1

Other Databases showing RASA1

Specialized Databases showing RASA1

Licensable Technologies
for RASA1

Services
for RASA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RASA1 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor RASA1

Summariesfor RASA1

Genomic Locationfor RASA1

Proteinsfor RASA1

Protein Domains/Familiesfor RASA1

Gene Functionfor RASA1

Pathways & Interactionsfor RASA1

Drugs & Compoundsfor RASA1

Transcriptsfor RASA1

Expression for RASA1

Orthologsfor RASA1

Paralogsfor RASA1

SNPs/Variantsfor RASA1

Disorders & Mutationsfor RASA1

Medical Newsfor RASA1

Publicationsfor RASA1

Search for RASA1

Genome Databases showing RASA1

Other Databases showing RASA1

Specialized Databases showing RASA1

Licensable Technologiesfor RASA1

Servicesfor RASA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RASA1

Summaries
for RASA1

Genomic Location
for RASA1

Proteins
for RASA1

Protein Domains/
Families
for RASA1

Gene Function
for RASA1

Pathways & Interactions
for RASA1

Drugs & Compounds
for RASA1

Transcripts
for RASA1

Expression
for RASA1

Orthologs
for RASA1

Paralogs
for RASA1

SNPs/Variants
for RASA1

Disorders & Mutations
for RASA1

Medical News
for RASA1

Publications
for RASA1

Licensable Technologies
for RASA1

Services
for RASA1