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Aliases for RARS Gene

Aliases for RARS Gene

  • Arginyl-TRNA Synthetase 4 2 3
  • EC 6.1.1.19 4 63
  • ArgRS 3 4
  • Arginyl-TRNA Synthetase, Cytoplasmic 3
  • Arginine TRNA Ligase 1, Cytoplasmic 3
  • Arginine TRNA Ligase 1 2
  • Cytoplasmic 2
  • DALRD1 3
  • HLD9 3

External Ids for RARS Gene

Previous GeneCards Identifiers for RARS Gene

  • GC05P168085
  • GC05P168554
  • GC05P167849
  • GC05P167894
  • GC05P167846
  • GC05P163012
  • GC05P167913

Summaries for RARS Gene

Entrez Gene Summary for RARS Gene

  • Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]

GeneCards Summary for RARS Gene

RARS (Arginyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with RARS include leukodystrophy, hypomyelinating, 9 and embryonal cancer. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include nucleotide binding and aminoacyl-tRNA ligase activity. An important paralog of this gene is RARS2.

UniProtKB/Swiss-Prot for RARS Gene

  • Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.

Gene Wiki entry for RARS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RARS Gene

Genomics for RARS Gene

Regulatory Elements for RARS Gene

Genomic Location for RARS Gene

Chromosome:
5
Start:
168,486,445 bp from pter
End:
168,519,306 bp from pter
Size:
32,862 bases
Orientation:
Plus strand

Genomic View for RARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RARS Gene

Proteins for RARS Gene

  • Protein details for RARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54136-SYRC_HUMAN
    Recommended name:
    Arginine--tRNA ligase, cytoplasmic
    Protein Accession:
    P54136
    Secondary Accessions:
    • B2RBS9
    • Q53GY4
    • Q9BWA1

    Protein attributes for RARS Gene

    Size:
    660 amino acids
    Molecular mass:
    75379 Da
    Quaternary structure:
    • Interacts (via N-terminus) with AIMP1 (via N-terminus); this stimulates its catalytic activity. Interacts (via N-terminus) with LARS2 (via C-terminus). Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro. Interacts with QARS.

    Three dimensional structures from OCA and Proteopedia for RARS Gene

    Alternative splice isoforms for RARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RARS Gene

Proteomics data for RARS Gene at MOPED

Post-translational modifications for RARS Gene

  • Ubiquitination at Lys 20, Lys 362, Lys 393, and Lys 557
  • Modification sites at PhosphoSitePlus

Other Protein References for RARS Gene

Antibody Products

Domains & Families for RARS Gene

Gene Families for RARS Gene

Suggested Antigen Peptide Sequences for RARS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54136

UniProtKB/Swiss-Prot:

SYRC_HUMAN :
  • The N-terminus (AA 1-72) has two regions predicted to be alpha-helical that might be involved in the multisynthetase complex assembly
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
Domain:
  • The N-terminus (AA 1-72) has two regions predicted to be alpha-helical that might be involved in the multisynthetase complex assembly
Family:
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with RARS: view

Function for RARS Gene

Molecular function for RARS Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.9 uM for arginine (ATP-PPi exchange at 37 degrees Celsius) {ECO:0000269 PubMed:16055448}; KM=3.5 uM for arginine (arginylation at 37 degrees Celsius) {ECO:0000269 PubMed:16055448}; KM=1183 uM for ATP (ATP-PPi exchange at 37 Celsius) {ECO:0000269 PubMed:16055448}; KM=910 uM for ATP (arginylation at 37 Celsius) {ECO:0000269 PubMed:16055448}; KM=0.05 uM for calf liver tRNA-Arg (ATP-PPi exchange at 37 Celsius) {ECO:0000269 PubMed:16055448}; KM=0.41 uM for calf liver tRNA-Arg (arginylation at 37 Celsius) {ECO:0000269 PubMed:16055448};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)
UniProtKB/Swiss-Prot Function:
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.

Enzyme Numbers (IUBMB) for RARS Gene

Gene Ontology (GO) - Molecular Function for RARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000166 nucleotide binding --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004814 arginine-tRNA ligase activity TAS --
GO:0005515 protein binding IPI 16055448
genes like me logo Genes that share ontologies with RARS: view

Phenotypes for RARS Gene

MGI mutant phenotypes for RARS:
inferred from 1 alleles
GenomeRNAi human phenotypes for RARS:
genes like me logo Genes that share phenotypes with RARS: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RARS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RARS Gene

Localization for RARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RARS Gene COMPARTMENTS Subcellular localization image for RARS gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 4
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for RARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RARS: view

Pathways & Interactions for RARS Gene

genes like me logo Genes that share pathways with RARS: view

Pathways by source for RARS Gene

1 KEGG pathway for RARS Gene

Gene Ontology (GO) - Biological Process for RARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006420 arginyl-tRNA aminoacylation IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with RARS: view

No data available for SIGNOR curated interactions for RARS Gene

Drugs & Compounds for RARS Gene

(30) Drugs for RARS Gene - From: HMDB, NovoSeek, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Deferasirox Approved, Investigational Pharma Oral iron chelator 83
Iron Approved Pharma 957
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
L-Arginine Approved Nutra Full agonist, Agonist 0

(23) Additional Compounds for RARS Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
12-O-Tetradecanoylphorbol 13-acetate
AGN 193109
Am 580
102121-60-8
Am80
genes like me logo Genes that share compounds with RARS: view

Transcripts for RARS Gene

Unigene Clusters for RARS Gene

Arginyl-tRNA synthetase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RARS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RARS Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - -
SP3: -
SP4: - - - -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for RARS Gene

GeneLoc Exon Structure for
RARS
ECgene alternative splicing isoforms for
RARS

Expression for RARS Gene

mRNA expression in normal human tissues for RARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RARS Gene

This gene is overexpressed in Breast (7.0), Lymph node (6.9), and Bone (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RARS Gene



SOURCE GeneReport for Unigene cluster for RARS Gene Hs.654907

genes like me logo Genes that share expression patterns with RARS: view

Protein tissue co-expression partners for RARS Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RARS Gene

Orthologs for RARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RARS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RARS 35
  • 90.4 (n)
  • 90.45 (a)
RARS 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RARS 35
  • 91.82 (n)
  • 93.03 (a)
RARS 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rars 35
  • 86.97 (n)
  • 91.52 (a)
Rars 16
Rars 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RARS 35
  • 99.65 (n)
  • 99.85 (a)
RARS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rars 35
  • 86.52 (n)
  • 91.52 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RARS 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves RARS 35
  • 77.37 (n)
  • 82.88 (a)
RARS 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RARS 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76310 35
rars 35
  • 73.38 (n)
  • 77.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6139 35
zebrafish
(Danio rerio)
Actinopterygii rars 35
  • 70.33 (n)
  • 76.98 (a)
wufa96g09 35
rars 36
  • 76 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.401 35
fruit fly
(Drosophila melanogaster)
Insecta CG9020 37
  • 58 (a)
Aats-arg 35
  • 57 (n)
  • 58.76 (a)
Aats-arg 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004708 35
  • 57.05 (n)
  • 57.72 (a)
worm
(Caenorhabditis elegans)
Secernentea rrt-1 37
  • 49 (a)
rars-1 35
  • 58.16 (n)
  • 54.47 (a)
rars-1 36
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 26 (a)
ManyToMany
MSR1 36
  • 23 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1027 35
  • 53.6 (n)
  • 49.3 (a)
soybean
(Glycine max)
eudicotyledons Gma.10893 35
rice
(Oryza sativa)
Liliopsida Os.6153 35
Os05g0163000 35
  • 53.77 (n)
  • 48.31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11500 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToOne
Species with no ortholog for RARS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RARS Gene

ENSEMBL:
Gene Tree for RARS (if available)
TreeFam:
Gene Tree for RARS (if available)

Paralogs for RARS Gene

Paralogs for RARS Gene

Pseudogenes.org Pseudogenes for RARS Gene

genes like me logo Genes that share paralogs with RARS: view

Variants for RARS Gene

Sequence variations from dbSNP and Humsavar for RARS Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_020106 -
VAR_020107 -
VAR_052635 -
VAR_072666 Leukodystrophy, hypomyelinating, 9 (HLD9)
VAR_072667 Leukodystrophy, hypomyelinating, 9 (HLD9)

Structural Variations from Database of Genomic Variants (DGV) for RARS Gene

Variant ID Type Subtype PubMed ID
nsv516697 CNV Loss 19592680

Variation tolerance for RARS Gene

Residual Variation Intolerance Score: 76.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RARS Gene

HapMap Linkage Disequilibrium report
RARS
Human Gene Mutation Database (HGMD)
RARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RARS Gene

Disorders for RARS Gene

MalaCards: The human disease database

(9) MalaCards diseases for RARS Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
leukodystrophy, hypomyelinating, 9
  • hld9
embryonal cancer
  • embryo neoplasm
hypervitaminosis a
transitional papilloma
  • transitional cell papilloma nos
keratomalacia
  • night blindness
- elite association
Search RARS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SYRC_HUMAN
  • Leukodystrophy, hypomyelinating, 9 (HLD9) [MIM:616140]: An autosomal recessive neurodegenerative disorder characterized by delayed psychomotor development, severe spasticity, nystagmus, and ataxia associated with diffuse hypomyelination apparent on brain MRI. {ECO:0000269 PubMed:24777941}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RARS

Genetic Association Database (GAD)
RARS
Human Genome Epidemiology (HuGE) Navigator
RARS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RARS
genes like me logo Genes that share disorders with RARS: view

No data available for Genatlas for RARS Gene

Publications for RARS Gene

  1. Cloning and characterization of cDNA encoding a human arginyl-tRNA synthetase. (PMID: 7590355) Girjes A.A. … Lavin M.F. (Gene 1995) 2 23 67
  2. {beta}-Apocarotenoids do not significantly activate retinoic acid receptors {alpha} or {beta}. (PMID: 20404052) Marsh R.S. … Harrison E.H. (Exp. Biol. Med. (Maywood) 2010) 23 67
  3. Gene regulation of CYP4F11 in human keratinocyte HaCaT cells. (PMID: 19812349) Wang Y. … Strobel H.W. (Drug Metab. Dispos. 2010) 23 67
  4. Identification of an inter-transcription factor regulatory network in human hepatoma cells by Matrix RNAi. (PMID: 19129217) Tomaru Y. … Suzuki M. (Nucleic Acids Res. 2009) 23 67
  5. Activation of retinoic acid receptors by dihydroretinoids. (PMID: 19770350) Moise A.R. … Palczewski K. (Mol. Pharmacol. 2009) 23 67

Products for RARS Gene

Sources for RARS Gene

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