Aliases for RARS Gene
External Ids for RARS Gene
Previous GeneCards Identifiers for RARS Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]
GeneCards Summary for RARS Gene
RARS (Arginyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with RARS include leukodystrophy, hypomyelinating, 9 and rars-related autosomal recessive hypomyelinating leukodystrophy. Among its related pathways are tRNA Aminoacylation and Gene Expression. GO annotations related to this gene include nucleotide binding and aminoacyl-tRNA ligase activity. An important paralog of this gene is RARS2.
UniProtKB/Swiss-Prot for RARS Gene
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.