Aliases for RARS Gene
External Ids for RARS Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]
GeneCards Summary for RARS Gene
RARS (Arginyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with RARS include leukodystrophy, hypomyelinating, 9. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include tRNA binding and arginine-tRNA ligase activity. An important paralog of this gene is RARS2.
UniProtKB/Swiss-Prot for RARS Gene
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.