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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RARS Gene

protein-coding   GIFtS: 66
GCID: GC05P167846

Arginyl-TRNA Synthetase

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arginyl-TRNA Synthetase1 2 3     DALRD12
ArgRS2 3     Arginine TRNA Ligase 1, Cytoplasmic2
EC 6.1.1.193 8     Arginine--TRNA Ligase, Cytoplasmic2
Arginine TRNA Ligase 11     Arginyl-TRNA Synthetase, Cytoplasmic2
cytoplasmic1     

External Ids:    HGNC: 98701   Entrez Gene: 59172   Ensembl: ENSG000001136437   OMIM: 1078205   UniProtKB: P541363   

Export aliases for RARS gene to outside databases

Previous GC identifers: GC05P168085 GC05P168554 GC05P167849 GC05P167894 GC05P163012


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RARS Gene:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their
central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are
thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I
aminoacyl-tRNA synthetase family. (provided by RefSeq, Jul 2008)

GeneCards Summary for RARS Gene: 
RARS (arginyl-tRNA synthetase) is a protein-coding gene. Diseases associated with RARS include craniopharyngioma, and appendicitis, and among its related super-pathways are Cytosolic tRNA aminoacylation and Generic Transcription Pathway. GO annotations related to this gene include tRNA binding and arginine-tRNA ligase activity. An important paralog of this gene is RARS2.

UniProtKB/Swiss-Prot: SYRC_HUMAN, P54136
Function: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate
tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the
inflammatory cytokine EMAP2 from AIMP1

Gene Wiki entry for RARS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RARS gene promoter:
         AP-1   ATF-2   SRY   POU2F1   HFH-1   POU2F1b   POU2F1c   c-Jun   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRARS promoter sequence
   Search SABiosciences Chromatin IP Primers for RARS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q34   HGNC cytogenetic band: 5q35.1

RARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RARS gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P167846:  view genomic region     (about GC identifiers)

Start:
167,913,450 bp from pter      End:
167,946,311 bp from pter
Size:
32,862 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYRC_HUMAN, P54136 (See protein sequence)
Recommended Name: Arginine--tRNA ligase, cytoplasmic  
Size: 660 amino acids; 75379 Da
Subunit: Interacts (via N-terminus) with AIMP1 (via N-terminus); this stimulates its catalytic activity. Interacts
(via N-terminus) with LARS2 (via C-terminus). Monomer; also part of a multisubunit complex that groups tRNA
ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro
Subcellular location: Cytoplasm
Secondary accessions: B2RBS9 Q53GY4 Q9BWA1
Alternative initiation: 2 isoforms:  P54136-1   P54136-2   

Explore the universe of human proteins at neXtProt for RARS: NX_P54136

Explore proteomics data for RARS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P54136

  • 4/19 DME Specific Peptides for RARS (P54136) (see all 19)
     FSFDKML  EIAGPGF  MHVGHLR  AGPGFIN 

    RARS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RARS Protein Expression
    REFSEQ proteins: NP_002878.2  
    ENSEMBL proteins: 
     ENSP00000231572   ENSP00000428494   ENSP00000430035   ENSP00000429030   ENSP00000439108  
    Reactome Protein details: P54136
    Human Recombinant Protein Products for RARS: 
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    Cloud-Clone Corp. Proteins for RARS 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    RARS for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    aaRS1: Aminoacyl tRNA synthetases / Class I

    5/7 InterPro protein domains (see all 7):
     IPR015945 Arg-tRNA-synth_Ia_core
     IPR005148 Arg-tRNA-synth_N
     IPR001412 aa-tRNA-synth_I_CS
     IPR008909 DALR_anticod-bd
     IPR001278 Arg-tRNA-ligase_Ia

    Graphical View of Domain Structure for InterPro Entry P54136

    ProtoNet protein and cluster: P54136

    1 Blocks protein domain: IPB005148 Arginyl tRNA synthetase N-terminal domain

    UniProtKB/Swiss-Prot: SYRC_HUMAN, P54136
    Domain: The N-terminus (AA 1-72) has two regions predicted to be alpha-helical that might be involved in the
    multisynthetase complex assembly
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


    RARS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYRC_HUMAN, P54136
    Function: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate
    tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the
    inflammatory cytokine EMAP2 from AIMP1
    Catalytic activity: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)
    Biophysicochemical properties: Kinetic parameters: KM=3.9 uM for arginine (ATP-PPi exchange at 37 degrees
    Celsius); KM=3.5 uM for arginine (arginylation at 37 degrees Celsius); KM=1183 uM for ATP (ATP-PPi exchange at 37
    Celsius); KM=910 uM for ATP (arginylation at 37 Celsius); KM=0.05 uM for calf liver tRNA-Arg (ATP-PPi exchange at
    37 Celsius); KM=0.41 uM for calf liver tRNA-Arg (arginylation at 37 Celsius);

         Enzyme Number (IUBMB): EC 6.1.1.191 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0000166nucleotide binding ----
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004814arginine-tRNA ligase activity TAS--
    GO:0005515protein binding IPI16055448
         
    RARS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RARS:
     Increased G2M DNA content, inc 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rars):
     mortality/aging 

    RARS for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RARS 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RARS 
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    miRNA
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    miRTarBase miRNAs that target RARS:
    hsa-mir-16 (MIRT001423)

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RARS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.54
    Cytosolic tRNA aminoacylation0.57
    2Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for RARS
        Cytosolic tRNA aminoacylation
    tRNA Aminoacylation
    Gene Expression


    1         Kegg Pathway  (Kegg details for RARS):
        Aminoacyl-tRNA biosynthesis


    RARS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/45 Interacting proteins for RARS (P541361, 2, 3 ENSP000002315724) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TANKQ928442, 3, ENSP000002590754MINT-48250 I2D: score=2 STRING: ENSP00000259075
    IKBKGQ9Y6K92, 3MINT-48136 I2D: score=2 
    MAP3K14Q995582, 3MINT-48789 I2D: score=2 
    NFKB2Q006532, 3MINT-48697 I2D: score=2 
    LARSQ9P2J51, 3, ENSP000003779544EBI-355482,EBI-356077 I2D: score=1 STRING: ENSP00000377954
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006420arginyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    RARS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RARS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RARS (SYRC)

    5 HMDB Compounds for RARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    10/46 Novoseek inferred chemical compound relationships for RARS gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 95.6 863 7927175 (4), 12242694 (4), 8385314 (4), 10999756 (4) (see all 99)
    retinoid 95.3 146 1656968 (3), 8470912 (2), 10495774 (2), 9756939 (2) (see all 99)
    am 580 87.3 4 8547646 (1), 14756521 (1), 8216300 (1), 11726401 (1)
    am80 87.3 2 14756521 (1), 10748721 (1)
    hx 600 86.6 1 9396157 (1)
    cd 437 85.2 7 10797258 (2), 10942519 (1), 9516142 (1), 8216300 (1) (see all 5)
    ttnpb 83.3 6 10495774 (3), 8547646 (1), 19812349 (1)
    cd 2019 80.2 2 8216300 (1), 11726401 (1)
    vitamin a 77.6 19 8394016 (2), 1320193 (1), 7989498 (1), 12921748 (1) (see all 16)
    ttab 74.5 1 9649304 (1)

    Search CenterWatch for drugs/clinical trials and news about RARS / SYRC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RARS gene: 
    NM_002887.3  

    Unigene Cluster for RARS:

    Arginyl-tRNA synthetase
    Hs.654907  [show with all ESTs]
    Unigene Representative Sequence: NM_002887
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231572(uc003lzx.3 uc011deo.2) ENST00000524082 ENST00000521329
    ENST00000522834 ENST00000521939 ENST00000520013 ENST00000519346 ENST00000518757
    ENST00000520421 ENST00000538719
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK222797.1 AK302161.1 AK314795.1 BC000528.2 BC014619.2 BT007394.1 

    20 DOTS entries:

    DT.418255  DT.95287978  DT.100872271  DT.100872265  DT.120844694  DT.424859  DT.120844712  DT.418257 
    DT.91862405  DT.97855000  DT.100872264  DT.100872275  DT.120844683  DT.120844698  DT.120844732  DT.40234546 
    DT.75155384  DT.95086189  DT.120844684  DT.92011379 

    24/487 AceView cDNA sequences (see all 487):

    AL517074 BM981513 CR608263 AU279891 BU789036 BM843804 BM999799 BC014619 
    CB108827 CR619064 AA831241 AA806532 BM682137 CR615478 CB133603 BE302240 
    AL037248 AA768123 CB134729 BQ277926 CA439316 CD679297 AL576368 BI856954 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RARS (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                    -     -                 -                       -           -           -                                                         
    SP2:                          -                 -                                                                                                         
    SP3:                                            -                                                                                                         
    SP4:                    -     -                 -                       -                                                                                 
    SP5:                    -     -                 -                                                                                                         


    ECgene alternative splicing isoforms for RARS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RARS expression in normal human tissues (normalized intensities)      RARS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGACACAAG
    RARS Expression
    About this image


    RARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
             ganglion/cranial   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Thymus (Hematopoietic System)
             Thymus

    See RARS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RARS

    SOURCE GeneReport for Unigene cluster: Hs.654907
        SABiosciences Custom PCR Arrays for RARS
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RARS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RARS gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rars1 , 5 arginyl-tRNA synthetase1, 5 86.97(n)1
    91.52(a)1
      11 (21.96 cM)5
    1044581  NM_025936.31  NP_080212.21 
     358083815 
    chicken
    (Gallus gallus)
    Aves RARS1 arginyl-tRNA synthetase 77.37(n)
    82.88(a)
      416168  NM_001030607.1  NP_001025778.1 
    lizard
    (Anolis carolinensis)
    Reptilia RARS6
    Uncharacterized protein
    83(a)
    1 ↔ 1
    1(112550768-112574864)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61392 Xenopus laevis transcribed sequence with moderate similarity more 76.71(n)    BX851980.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa96g092 wufa96g09 74.71(n)   337070  BC045884.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90203
    Aats-arg1
    arginine-tRNA ligase3
    Arginyl-tRNA synthetase1
    58(a)3
    56.9(n)1
    58.76(a)1
      13F103
    325391  NM_132853.21  NP_573081.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rrt-13
    rars-11
    arginyl tRNA synthetase3
    Protein RARS-11
    49(a)3
    57.54(n)1
    54.46(a)1
      III(4986003-4987055)3
    1756591  NM_001027380.41  NP_001022551.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YDR341C6
    MSR16
    Mitochondrial arginyl-tRNA synthetase
    24(a)
    22(a)
    many ↔ many
    many ↔ many
    IV(1151803-1153626)
    VIII(284839-286770)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons emb10271 Arginyl-tRNA synthetase, class Ic 53.54(n)
    49.3(a)
      828736  NM_118763.3  NP_194360.1 
    rice
    (Oryza sativa)
    Liliopsida Os.61532 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 81.5(n)    AK066161.1 


    ENSEMBL Gene Tree for RARS (if available)
    TreeFam Gene Tree for RARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RARS gene
    RARS22  
    18/43 SIMAP similar genes for RARS using alignment to 5 protein entries:     SYRC_HUMAN (see all proteins) (see all similar genes):
    CALCOCO2    IK    C14orf105    CDK10    ZNF559    VPS33A
    ZNF799    RQCD1    C12orf76    COQ5    EIF3G    NAE1
    TUBA1C    DYNC2LI1    KIAA0101    RRM2B    SLC35E3    AAMDC

    RARS for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RARS
    PGOHUM00000239712


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/916 SNPs in RARS are shown (see all 916)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391901561,2
    --167911516(+) ATGGCC/TGACAT 1 -- us2k10--------
    rs352549791,2
    C--167911676(+) TTTTTT/-GAGAC 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs117460781,2
    C,F,A,H--167911710(+) ctggaA/Gtgcag 1 -- us2k13Minor allele frequency- G:0.48NA EA 124
    rs117460801,2
    H--167911722(+) ggccaA/Gatcat 1 -- us2k10--------
    rs121883041,2
    C,F,A--167911734(+) gctcaC/Ttgcaa 1 -- us2k15Minor allele frequency- T:0.19WA CSA NA EA 362
    rs1908367271,2
    --167911817(+) CCATGC/TCTGGC 1 -- us2k10--------
    rs1179049471,2
    C,F--167911848(+) AGAGAC/TGATGT 1 -- us2k11Minor allele frequency- T:0.04EA 120
    rs1822275611,2
    --167911890(+) CCTGGA/GCTCAA 1 -- us2k10--------
    rs1414093731,2
    --167911964(+) TCGATA/GTCAAC 1 -- us2k10--------
    rs1875988381,2
    --167912001(+) ATTTTA/TAAAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RARS (167913450 - 167946311 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RARS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516697CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107820    OMIM disorders: --

    20/51 diseases for RARS (see all 51):    About MalaCards
    craniopharyngioma    appendicitis    prostate adenocarcinoma    ductal carcinoma in situ
    thrombocytosis    endometrial adenocarcinoma    teratocarcinoma    non-small cell lung carcinoma
    monocytic leukemia    acute promyelocytic leukemia    psoriasis    retinoblastoma
    adenocarcinoma    myeloid leukemia    basal cell carcinoma    kaposi's sarcoma
    esophageal cancer    prostatitis    oral squamous cell carcinoma    gastric cancer

    4 diseases from the University of Copenhagen DISEASES database for RARS:
    Anemia     Leukemia     Thrombocytosis     Embryonal carcinoma

    RARS for disorders           About GeneDecksing

    10/41 Novoseek inferred disease relationships for RARS gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia promyelocytic acute 75.4 6 8839862 (1), 15189119 (1), 12188922 (1), 11806973 (1) (see all 6)
    carcinoma embryonal 66.2 3 10854244 (1), 8650243 (1), 1327537 (1)
    salivary gland adenocarcinoma 54.9 1 10668629 (1)
    myeloid leukemia 46.1 1 17431504 (1)
    premalignant 45 2 10389997 (1), 12452454 (1)
    promyelocytic leukemia 43.1 2 17431504 (1), 10748721 (1)
    vitamin a deficiency 34.2 1 12921748 (1)
    leukemia 33.9 3 15896339 (1), 8547646 (1), 7630633 (1)
    cancer 32.6 12 15189119 (1), 15266311 (1), 12188922 (1), 9150186 (1) (see all 12)
    hnscc 29.6 1 11340568 (1)

    Genetic Association Database (GAD): RARS
    Human Genome Epidemiology (HuGE) Navigator: RARS (12 documents)

    Export disorders for RARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RARS gene, integrated from 9 sources (see all 476):
    (articles sorted by number of sources associating them with RARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of cDNA encoding a human arginyl-tRNA synthetase. (PubMed id 7590355)1, 2, 3, 9 Girjes A.A.... Lavin M.F. (1995)
    2. The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex. (PubMed id 16055448)1, 2, 9 Ling C....Wang E.D. (2005)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines. (PubMed id 17443684)1, 2 Bottoni A....Uberti E.C. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase. (PubMed id 10358004)1, 2 Park S.G....Shiba K. (1999)
    8. Two forms of human cytoplasmic arginyl-tRNA synthetase produced from two translation initiations by a single mRNA. (PubMed id 16430231)2, 9 Zheng Y.-G.... Wang E.-D. (2006)
    9. Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex. (PubMed id 10801842)1, 9 Kim T....Kim S. (2000)
    10. A multifunctional repeated motif is present in human bifunctional tRNA synthetase. (PubMed id 9556618)1, 9 Rho S.B....Kim S. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5917 HGNC: 9870 AceView: RARS Ensembl:ENSG00000113643 euGenes: HUgn5917
    ECgene: RARS Kegg: 5917 H-InvDB: RARS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RARS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RARS gene:
    Search GeneIP for patents involving RARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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