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Aliases for RARRES3 Gene

Aliases for RARRES3 Gene

  • Retinoic Acid Receptor Responder (Tazarotene Induced) 3 2 3
  • TIG3 3 4 6
  • Retinoid-Inducible Gene 1 Protein 3 4
  • Tazarotene-Induced Gene 3 Protein 3 4
  • RAR-Responsive Protein TIG3 3 4
  • HRAS-Like Suppressor 4 3 4
  • HRSL4 3 4
  • RIG1 3 4
  • Retinoic Acid Receptor Responder Protein 3 3
  • Retinoic Acid-Inducible Gene 1 3
  • EC 3.1.1.- 4
  • PLA1/2-3 3
  • HRASLS4 3

External Ids for RARRES3 Gene

Summaries for RARRES3 Gene

Entrez Gene Summary for RARRES3 Gene

  • Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]

GeneCards Summary for RARRES3 Gene

RARRES3 (Retinoic Acid Receptor Responder (Tazarotene Induced) 3) is a Protein Coding gene. Diseases associated with RARRES3 include colorectal adenocarcinoma. GO annotations related to this gene include phospholipase A2 activity. An important paralog of this gene is HRASLS.

UniProtKB/Swiss-Prot for RARRES3 Gene

  • Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable.

Gene Wiki entry for RARRES3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RARRES3 Gene

Genomics for RARRES3 Gene

Genomic Location for RARRES3 Gene

Start:
63,536,801 bp from pter
End:
63,546,462 bp from pter
Size:
9,662 bases
Orientation:
Plus strand

Genomic View for RARRES3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RARRES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RARRES3 Gene

Regulatory Elements for RARRES3 Gene

Proteins for RARRES3 Gene

  • Protein details for RARRES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL19-HRSL4_HUMAN
    Recommended name:
    Retinoic acid receptor responder protein 3
    Protein Accession:
    Q9UL19
    Secondary Accessions:
    • B2R599
    • B4DDW2
    • E7ENZ7
    • O95200

    Protein attributes for RARRES3 Gene

    Size:
    164 amino acids
    Molecular mass:
    18179 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RARRES3 Gene

    Alternative splice isoforms for RARRES3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RARRES3 Gene

Proteomics data for RARRES3 Gene at MOPED

Post-translational modifications for RARRES3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RARRES3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RARRES3 Gene

Domains for RARRES3 Gene

Protein Domains for RARRES3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RARRES3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL19

UniProtKB/Swiss-Prot:

HRSL4_HUMAN
Family:
  • Belongs to the H-rev107 family.:
    • Q9UL19
genes like me logo Genes that share domains with RARRES3: view

No data available for Gene Families for RARRES3 Gene

Function for RARRES3 Gene

Molecular function for RARRES3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=400 uM for dipalmitoyl-PC {ECO:0000269 PubMed:19615464}; Vmax=530 nmol/min/mg enzyme with dipalmitoyl-PC as substrate {ECO:0000269 PubMed:19615464}; Vmax=240 nmol/min/mg enzyme with dipalmitoyl-PE as substrate {ECO:0000269 PubMed:19615464}; pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:19615464};
UniProtKB/Swiss-Prot Function: Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable.
UniProtKB/Swiss-Prot Induction: By all-trans-retinoic acid and synthetic retinoids.

Enzyme Numbers (IUBMB) for RARRES3 Gene

Gene Ontology (GO) - Molecular Function for RARRES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IDA 20100577
GO:0005515 protein binding IPI 22908223
genes like me logo Genes that share ontologies with RARRES3: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RARRES3 Gene

Localization for RARRES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RARRES3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RARRES3 Gene COMPARTMENTS Subcellular localization image for RARRES3 gene
Compartment Confidence
plasma membrane 2
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RARRES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RARRES3: view

Pathways for RARRES3 Gene

SuperPathways for RARRES3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RARRES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IDA 20100577
GO:0008285 negative regulation of cell proliferation TAS 9843971
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with RARRES3: view

No data available for Pathways by source for RARRES3 Gene

Compounds for RARRES3 Gene

(3) Novoseek inferred chemical compound relationships for RARRES3 Gene

Compound -log(P) Hits PubMed IDs
retinoid 76.8 7
retinoic acid 73.9 21
tazarotene 73.6 4
genes like me logo Genes that share compounds with RARRES3: view

Transcripts for RARRES3 Gene

Unigene Clusters for RARRES3 Gene

Retinoic acid receptor responder (tazarotene induced) 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RARRES3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for RARRES3 Gene

GeneLoc Exon Structure for
RARRES3
ECgene alternative splicing isoforms for
RARRES3

Expression for RARRES3 Gene

mRNA expression in normal human tissues for RARRES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RARRES3 Gene

This gene is overexpressed in Kidney - Cortex (6.0).

SOURCE GeneReport for Unigene cluster for RARRES3 Gene Hs.17466

mRNA Expression by UniProt/SwissProt for RARRES3 Gene

Q9UL19-HRSL4_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with RARRES3: view

No data available for Protein expression for RARRES3 Gene

Orthologs for RARRES3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RARRES3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RARRES3 35
  • 99.8 (n)
  • 99.39 (a)
RARRES3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RARRES3 35
  • 75.57 (n)
  • 64.6 (a)
RARRES3 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR383676.3 36
  • 50 (a)
ManyToMany
CU138503.3 36
  • 45 (a)
ManyToMany
LOC100330001 35
  • 58.49 (n)
  • 52.26 (a)
zgc:154040 36
  • 43 (a)
ManyToMany
zgc:92249 36
  • 45 (a)
ManyToMany
Species with no ortholog for RARRES3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RARRES3 Gene

ENSEMBL:
Gene Tree for RARRES3 (if available)
TreeFam:
Gene Tree for RARRES3 (if available)

Paralogs for RARRES3 Gene

Paralogs for RARRES3 Gene

Selected SIMAP similar genes for RARRES3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RARRES3: view

Variants for RARRES3 Gene

Sequence variations from dbSNP and Humsavar for RARRES3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs584905 -- 63,546,172(-) ACACC(A/G)ACTTC reference, synonymous-codon
rs870073 -- 63,546,450(+) CATCT(G/T)CCCCT utr-variant-3-prime
rs870074 -- 63,546,568(+) CTTTA(A/G)AGAAG downstream-variant-500B
rs1802338 -- 63,544,690(+) ACGGG(A/G)GCGCC reference, missense
rs1802339 -- 63,544,721(+) TGTTG(C/T)TATCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RARRES3 Gene

Variant ID Type Subtype PubMed ID
nsv468588 CNV Loss 19166990
nsv509417 CNV Insertion 20534489

Relevant External Links for RARRES3 Gene

HapMap Linkage Disequilibrium report
RARRES3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RARRES3 Gene

Disorders for RARRES3 Gene

(1) MalaCards Diseases for RARRES3 Gene

Search for RARRES3 Gene in MalaCards »

(7) Novoseek inferred disease relationships for RARRES3 Gene

Disease -log(P) Hits PubMed IDs
psoriasis 39 2
tumors 24.2 16
adenoma 20 4
gastric cancer 18.3 2
adenocarcinoma 6.21 4

Relevant External Links for RARRES3

Genetic Association Database (GAD)
RARRES3
Human Genome Epidemiology (HuGE) Navigator
RARRES3
genes like me logo Genes that share disorders with RARRES3: view

No data available for UniProtKB/Swiss-Prot for RARRES3 Gene

Publications for RARRES3 Gene

  1. Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. (PMID: 9843971) DiSepio D. … Nagpal S. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  2. Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells. (PMID: 10687848) Huang S.L. … Jiang S.Y. (Mol. Cell. Endocrinol. 2000) 3 4 23
  3. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PMID: 19615464) Uyama T. … Ueda N. (Biochim. Biophys. Acta 2009) 3 4 23
  4. RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. (PMID: 17196792) Tsai F.M. … Jiang S.Y. (Cell. Signal. 2007) 3 23
  5. Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms. (PMID: 15856468) Lotz K. … Sers C. (Int. J. Cancer 2005) 3 23

Products for RARRES3 Gene

Sources for RARRES3 Gene

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