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Aliases for RARRES3 Gene

Aliases for RARRES3 Gene

  • Retinoic Acid Receptor Responder 3 2 3
  • Retinoic Acid Receptor Responder (Tazarotene Induced) 3 2 3 5
  • Retinoid-Inducible Gene 1 Protein 3 4
  • Tazarotene-Induced Gene 3 Protein 3 4
  • RAR-Responsive Protein TIG3 3 4
  • HRAS-Like Suppressor 4 3 4
  • HRSL4 3 4
  • RIG1 3 4
  • TIG3 3 4
  • Retinoic Acid-Inducible Gene 1 3
  • EC 3.1.1.- 4
  • PLA1/2-3 3
  • HRASLS4 3

External Ids for RARRES3 Gene

Previous GeneCards Identifiers for RARRES3 Gene

  • GC11P065816
  • GC11P064879
  • GC11P063555
  • GC11P063079
  • GC11P063060
  • GC11P063304
  • GC11P059633

Summaries for RARRES3 Gene

Entrez Gene Summary for RARRES3 Gene

  • Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]

GeneCards Summary for RARRES3 Gene

RARRES3 (Retinoic Acid Receptor Responder 3) is a Protein Coding gene. Diseases associated with RARRES3 include Poland Syndrome. GO annotations related to this gene include phospholipase A2 activity. An important paralog of this gene is HRASLS.

UniProtKB/Swiss-Prot for RARRES3 Gene

  • Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable.

Gene Wiki entry for RARRES3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RARRES3 Gene

Genomics for RARRES3 Gene

Regulatory Elements for RARRES3 Gene

Enhancers for RARRES3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RARRES3 on UCSC Golden Path with GeneCards custom track

Promoters for RARRES3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RARRES3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RARRES3 Gene

63,536,801 bp from pter
63,546,462 bp from pter
9,662 bases
Plus strand

Genomic View for RARRES3 Gene

Genes around RARRES3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RARRES3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RARRES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RARRES3 Gene

Proteins for RARRES3 Gene

  • Protein details for RARRES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinoic acid receptor responder protein 3
    Protein Accession:
    Secondary Accessions:
    • B2R599
    • B4DDW2
    • E7ENZ7
    • O95200

    Protein attributes for RARRES3 Gene

    164 amino acids
    Molecular mass:
    18179 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RARRES3 Gene

    Alternative splice isoforms for RARRES3 Gene


neXtProt entry for RARRES3 Gene

Proteomics data for RARRES3 Gene at MOPED

Post-translational modifications for RARRES3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RARRES3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RARRES3 Gene

Domains & Families for RARRES3 Gene

Gene Families for RARRES3 Gene

Protein Domains for RARRES3 Gene


Suggested Antigen Peptide Sequences for RARRES3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the H-rev107 family.
  • Belongs to the H-rev107 family.
genes like me logo Genes that share domains with RARRES3: view

Function for RARRES3 Gene

Molecular function for RARRES3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=400 uM for dipalmitoyl-PC {ECO:0000269 PubMed:19615464}; Vmax=530 nmol/min/mg enzyme with dipalmitoyl-PC as substrate {ECO:0000269 PubMed:19615464}; Vmax=240 nmol/min/mg enzyme with dipalmitoyl-PE as substrate {ECO:0000269 PubMed:19615464}; pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:19615464};
UniProtKB/Swiss-Prot Function:
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable.
UniProtKB/Swiss-Prot Induction:
By all-trans-retinoic acid and synthetic retinoids.

Enzyme Numbers (IUBMB) for RARRES3 Gene

genes like me logo Genes that share phenotypes with RARRES3: view

Animal Model Products

CRISPR Products

miRNA for RARRES3 Gene

miRTarBase miRNAs that target RARRES3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RARRES3 Gene

Localization for RARRES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RARRES3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RARRES3 Gene COMPARTMENTS Subcellular localization image for RARRES3 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for RARRES3 Gene

Pathways & Interactions for RARRES3 Gene

SuperPathways for RARRES3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RARRES3 Gene


No data available for Pathways by source and SIGNOR curated interactions for RARRES3 Gene

Drugs & Compounds for RARRES3 Gene

(1) Drugs for RARRES3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RARRES3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RARRES3: view

Transcripts for RARRES3 Gene

Unigene Clusters for RARRES3 Gene

Retinoic acid receptor responder (tazarotene induced) 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RARRES3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for RARRES3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RARRES3 Gene

mRNA expression in normal human tissues for RARRES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RARRES3 Gene

This gene is overexpressed in Kidney - Cortex (x6.0).

SOURCE GeneReport for Unigene cluster for RARRES3 Gene Hs.17466

mRNA Expression by UniProt/SwissProt for RARRES3 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RARRES3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RARRES3 Gene

Orthologs for RARRES3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RARRES3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RARRES3 35
  • 75.57 (n)
  • 64.6 (a)
  • 65 (a)
(Pan troglodytes)
Mammalia RARRES3 35
  • 99.8 (n)
  • 99.39 (a)
  • 99 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
-- 36
  • 40 (a)
-- 36
  • 26 (a)
-- 36
  • 43 (a)
-- 36
  • 39 (a)
(Danio rerio)
Actinopterygii LOC100330001 35
  • 58.49 (n)
  • 52.26 (a)
CR383676.3 36
  • 50 (a)
CU138503.3 36
  • 45 (a)
zgc:154040 36
  • 43 (a)
zgc:92249 36
  • 45 (a)
Species with no ortholog for RARRES3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RARRES3 Gene

Gene Tree for RARRES3 (if available)
Gene Tree for RARRES3 (if available)

Paralogs for RARRES3 Gene

Paralogs for RARRES3 Gene

(4) SIMAP similar genes for RARRES3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RARRES3: view

Variants for RARRES3 Gene

Sequence variations from dbSNP and Humsavar for RARRES3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35502888 - 63,544,707(+) ATGTG(C/G)TGGGA reference, missense
rs35845275 - 63,546,246(+) AAAAG(C/T)GACAG reference, missense
rs584905 -- 63,546,172(-) ACACC(A/G)ACTTC reference, synonymous-codon
rs870073 -- 63,546,450(+) CATCT(G/T)CCCCT utr-variant-3-prime
rs870074 -- 63,546,568(+) CTTTA(A/G)AGAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RARRES3 Gene

Variant ID Type Subtype PubMed ID
nsv468588 CNV Loss 19166990
nsv509417 CNV Insertion 20534489

Variation tolerance for RARRES3 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RARRES3 Gene

Disorders for RARRES3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RARRES3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
poland syndrome
  • poland sequence
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RARRES3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RARRES3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RARRES3 Gene

Publications for RARRES3 Gene

  1. Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. (PMID: 9843971) DiSepio D. … Nagpal S. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23 67
  2. Induction of apoptosis by the retinoid inducible growth regulator RIG1 depends on the NC motif in HtTA cervical cancer cells. (PMID: 19245694) Tsai F.M. … Jiang S.Y. (BMC Cell Biol. 2009) 3 23
  3. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PMID: 19615464) Uyama T. … Ueda N. (Biochim. Biophys. Acta 2009) 3 23
  4. RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. (PMID: 17196792) Tsai F.M. … Jiang S.Y. (Cell. Signal. 2007) 3 23
  5. Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms. (PMID: 15856468) Lotz K. … Sers C. (Int. J. Cancer 2005) 3 23

Products for RARRES3 Gene

Sources for RARRES3 Gene