Aliases for RARRES3 Gene
External Ids for RARRES3 Gene
Previous GeneCards Identifiers for RARRES3 Gene
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
GeneCards Summary for RARRES3 Gene
RARRES3 (Retinoic Acid Receptor Responder 3) is a Protein Coding gene. Diseases associated with RARRES3 include Psoriasis and Poland Syndrome. Among its related pathways are Metabolism and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity. An important paralog of this gene is HRASLS2.
UniProtKB/Swiss-Prot for RARRES3 Gene
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable.