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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RARRES3 Gene

protein-coding   GIFtS: 53
GCID: GC11P063304

retinoic acid receptor responder (tazarotene induced) 3

 Explore 24 diseases affiliated with
RARRES3 via our new
 Human Malady Compendium 
Biological research products
for RARRES3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Retinoic Acid Receptor Responder (Tazarotene Induced) 31 2     HRAS-Like Suppressor 42 3
TIG31 2 3 5     RAR-Responsive Protein TIG32 3
HRASLS41 2     PLA1/2-32
Retinoid-Inducible Gene 1 Protein2 3     Retinoic Acid Receptor Responder Protein 32
Tazarotene-Induced Gene 3 Protein2 3     Retinoic Acid-Inducible Gene 12
HRSL42 3     EC 3.1.1.-3
RIG12 3     

External Ids:    HGNC: 98691   Entrez Gene: 59202   Ensembl: ENSG000001333217   OMIM: 6050925   UniProtKB: Q9UL193   

Export aliases for RARRES3 gene to outside databases

Previous GC identifers: GC11P065816 GC11P064879 GC11P063555 GC11P063079 GC11P063060 GC11P059633


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RARRES3:
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in
the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor
proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.
RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3
is thought act as a tumor suppressor or growth regulator. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HRSL4_HUMAN, Q9UL19
Function: Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various
phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than
PLA2 activity. N- and O-acylation activity is hardly detectable

Gene Wiki entry for RARRES3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RARRES3 gene promoter:
         GR   POU2F1   p53   POU2F1a   CUTL1   GR-alpha   XBP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRARRES3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RARRES3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RARRES3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q23

RARRES3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RARRES3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063304:  view genomic region     (about GC identifiers)

Start:
63,304,273 bp from pter      End:
63,313,934 bp from pter
Size:
9,662 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HRSL4_HUMAN, Q9UL19 (See protein sequence)
Recommended Name: Retinoic acid receptor responder protein 3  
Size: 164 amino acids; 18179 Da
Subcellular location: Membrane; Single-pass membrane protein (By similarity)
1 PDB 3D structure from and Proteopedia for RARRES3:
2LKT (3D)    
Secondary accessions: B2R599 B4DDW2 E7ENZ7 O95200
Alternative splicing: 2 isoforms:  Q9UL19-1   Q9UL19-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RARRES3: NX_Q9UL19

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UL19

  • RARRES3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004576.2  
    ENSEMBL proteins: 
     ENSP00000402943   ENSP00000255688   ENSP00000346431  

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    Uscn Proteins for RARRES3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    RARRES3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RARRES3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007053 LRAT-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UL19

    ProtoNet protein and cluster: Q9UL19

    1 Blocks protein family: IPB007053 NC

    UniProtKB/Swiss-Prot: HRSL4_HUMAN, Q9UL19
    Similarity: Belongs to the H-rev107 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HRSL4_HUMAN, Q9UL19
    Function: Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various
    phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than
    PLA2 activity. N- and O-acylation activity is hardly detectable
    Biophysicochemical properties: Kinetic parameters: KM=400 uM for dipalmitoyl-PC; Vmax=530 nmol/min/mg enzyme with
    dipalmitoyl-PC as substrate; Vmax=240 nmol/min/mg enzyme with dipalmitoyl-PE as substrate; pH dependence: Optimum pH
    is 8;
    Induction: By all-trans-retinoic acid and synthetic retinoids

    Enzyme Number (IUBMB): EC 3.1.1.-1

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004623phospholipase A2 activity IDA--


    RARRES3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RARRES3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/13 Interacting proteins for RARRES3 (Q9UL193 ENSP000002556884) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=2 STRING: ENSP00000309845
    TGM1P227353, ENSP000002067654I2D: score=2 STRING: ENSP00000206765
    TRIM25Q142583, ENSP000003238894I2D: score=1 STRING: ENSP00000323889
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process IDA--
    GO:0008285negative regulation of cell proliferation TAS9843971
    GO:0016042lipid catabolic process IEA--


    RARRES3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RARRES3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RARRES3
    3 Novoseek chemical compound relationships for RARRES3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoid 76.8 7 10687848 (2), 12879006 (2), 14632211 (2), 9843971 (1)
    retinoic acid 73.9 31 12879006 (8), 10687848 (2), 7974255 (1), 11587209 (1) (see all 13)
    tazarotene 73.6 5 14632211 (3), 9843971 (1)

    Search CenterWatch for drugs/clinical trials and news about RARRES3 / HRSL4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RARRES3 gene: 
    NM_004585.3  

    Unigene Cluster for RARRES3:

    Retinoic acid receptor responder (tazarotene induced) 3
    Hs.17466  [show with all ESTs]
    Unigene Representative Sequence: AK123723
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537871 ENST00000439013 ENST00000255688(uc001nxf.4) ENST00000544107
    ENST00000354445

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    Additional cDNA sequence: 

    AB030815.1 AB453252.1 AF060228.1 AF092922.1 AK123723.1 AK293357.1 AK312110.1 BC009678.1 

    5 DOTS entries:

    DT.213717  DT.101962828  DT.75138203  DT.95324724  DT.91804180 

    24/128 AceView cDNA sequences (see all 128):

    H27627 BI754816 AK123723 AA976825 BM726379 AI560363 BG231625 BE902015 
    AI884672 AI709302 AI884980 BQ445876 BM773478 BM019969 CF529931 AI245170 
    AI418642 AF060228 AI090072 BI756179 BE786199 AA650633 BF762016 CD672962 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RARRES3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for RARRES3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RARRES3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTCCAGCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    RARRES3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RARRES3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RARRES3

    SOURCE GeneReport for Unigene cluster: Hs.17466

    UniProtKB/Swiss-Prot: HRSL4_HUMAN, Q9UL19
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RARRES3 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii BQ480551.12   -- 75.33(n)    BQ480551.1 


    ENSEMBL Gene Tree for RARRES3 (if available)
    TreeFam Gene Tree for RARRES3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RARRES3 gene
    PLA2G162  HRASLS2  HRASLS22  HRASLS52  
    4 SIMAP similar genes for RARRES3 using alignment to 2 protein entries:     HRSL4_HUMAN (see all proteins):
    HRASLS2    PLA2G16    HRASLS    HRASLS5

    RARRES3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/179 NCBI SNPs in RARRES3 are shown (see all 179    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs616812381,2
    C,F,--63302305(+) AAGGCA/GTAAAT 1 -- us2k13Minor allele frequency- G:0.15WA 122
    rs1884392811,2
    --63302403(+) GTTGAA/TTGCAG 1 -- us2k10--------
    rs351092551,2
    C,F,--63302422(+) GGGGGC/TCCCCT 1 -- us2k16Minor allele frequency- T:0.05MN WA 526
    rs358695051,2
    C,F,--63302434(+) AAAGAG/ATTTTG 1 -- us2k15Minor allele frequency- A:0.01MN 408
    rs359511011,2
    C,F,--63302453(+) AATATT/CTCAAA 1 -- us2k15Minor allele frequency- C:0.01MN 408
    rs1414827061,2
    C,--63302518(+) AAATG-/ATAAA 
     CATAGGT
    ATAAA
    1 -- us2k10--------
    rs359014641,2
    C,F,--63302552(+) TAAGAT/GAACAT 1 -- us2k15Minor allele frequency- G:0.01MN 408
    rs1442024211,2
    --63302589(+) CTGATA/GAGAAA 1 -- us2k10--------
    rs1828207071,2
    --63302748(+) TGGAAA/GCTCTG 1 -- us2k10--------
    rs1870623821,2
    --63302758(+) GCCCAA/CACACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RARRES3 (63304273 - 63313934 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RARRES3: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RARRES3 for disorders           About GeneDecksing

    OMIM gene information: 605092    OMIM disorders: --

    20/24 diseases for RARRES3 (see all 24):    About MalaCards
    dengue hemorrhagic fever    hemorrhagic fever    uterine fibroid    basal cell carcinoma
    tauopathy    wilms tumor    thyroiditis    gastric cancer
    lymphocytic leukemia    psoriasis    crohn's disease    skin cancer
    breast cancer    hepatocellular carcinoma    ovarian carcinoma    cervical cancer
    cervicitis    ovarian cancer    lung carcinoma    carcinoma

    7 Novoseek disease relationships for RARRES3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 39 2 10955811 (1), 14632211 (1)
    tumors 24.2 21 15856468 (4), 19615464 (3), 12879006 (2), 9843971 (1) (see all 10)
    adenoma 20 4 12838316 (3), 16426842 (1)
    gastric cancer 18.3 2 10687848 (1), 12014653 (1)
    adenocarcinoma 6.21 5 12838316 (3), 16426842 (1)
    breast cancer 0 15 16080475 (6), 9843971 (1)
    cancer 0 2 9843971 (1), 12879006 (1)

    Human Genome Epidemiology (HuGE) Navigator: RARRES3 (4 documents)

    Export disorders for RARRES3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RARRES3 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with RARRES3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. (PubMed id 9843971)1, 2, 9 DiSepio D.... Nagpal S. (1998)
    2. Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells. (PubMed id 10687848)1, 2, 9 Huang S.L....Jiang S.Y. (2000)
    3. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PubMed id 19615464)1, 2, 9 Uyama T.... Ueda N. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Molecular mechanisms of tazarotene action in psoriasis. (PubMed id 9270552)1, 3 Duvic M....Chandraratna R.A. (1997)
    6. Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms. (PubMed id 15856468)1, 9 Lotz K....Sers C. (2005)
    7. RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. (PubMed id 17196792)1, 9 Tsai F.M....Jiang S.Y. (2007)
    8. Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype. (PubMed id 12879006)1, 9 Higuchi E....Lotan R. (2003)
    9. A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase. (PubMed id 12928434)1, 9 Sturniolo M.T....Eckert R.L. (2003)
    10. Downregulation of HER2 by RIG1 involves the PI3K/Akt pathway in ovarian cancer cells. (PubMed id 18174256)1, 9 Ou C.C....Kao M.C. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5920 HGNC: 9869 AceView: RARRES3 Ensembl:ENSG00000133321 euGenes: HUgn5920
    ECgene: RARRES3 H-InvDB: RARRES3

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RARRES3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RARRES3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
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    Patent Information for RARRES3 gene:
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