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RARRES3 Gene

protein-coding   GIFtS: 55
GCID: GC11P063304

Retinoic Acid Receptor Responder (Tazarotene Induced) 3

  See RARRES3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Retinoic Acid Receptor Responder (Tazarotene Induced) 31 2     RAR-Responsive Protein TIG32 3
TIG32 3 5     HRASLS42
Retinoid-Inducible Gene 1 Protein2 3     PLA1/2-32
Tazarotene-Induced Gene 3 Protein2 3     Retinoic Acid Receptor Responder Protein 32
HRSL42 3     Retinoic Acid-Inducible Gene 12
RIG12 3     EC 3.1.1.-3
HRAS-Like Suppressor 42 3     

External Ids:    HGNC: 98691   Entrez Gene: 59202   Ensembl: ENSG000001333217   OMIM: 6050925   UniProtKB: Q9UL193   

Export aliases for RARRES3 gene to outside databases

Previous GC identifers: GC11P065816 GC11P064879 GC11P063555 GC11P063079 GC11P063060 GC11P059633


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RARRES3 Gene:
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used
in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear
receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional
regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid
tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. (provided by RefSeq, Jul 2008)

GeneCards Summary for RARRES3 Gene:
RARRES3 (retinoic acid receptor responder (tazarotene induced) 3) is a protein-coding gene. Diseases associated with RARRES3 include colorectal adenocarcinoma. GO annotations related to this gene include phospholipase A2 activity. An important paralog of this gene is PLA2G16.

UniProtKB/Swiss-Prot: HRSL4_HUMAN, Q9UL19
Function: Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various
phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher
than PLA2 activity. N- and O-acylation activity is hardly detectable

Gene Wiki entry for RARRES3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RARRES3 gene promoter:
         GR   POU2F1   p53   POU2F1a   CUTL1   GR-alpha   XBP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRARRES3 promoter sequence
   Search Chromatin IP Primers for RARRES3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RARRES3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q23

RARRES3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RARRES3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063304:  view genomic region     (about GC identifiers)

Start:
63,304,273 bp from pter      End:
63,313,934 bp from pter
Size:
9,662 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HRSL4_HUMAN, Q9UL19 (See protein sequence)
Recommended Name: Retinoic acid receptor responder protein 3  
Size: 164 amino acids; 18179 Da
1 PDB 3D structure from and Proteopedia for RARRES3:
2LKT (3D)    
Secondary accessions: B2R599 B4DDW2 E7ENZ7 O95200
Alternative splicing: 2 isoforms:  Q9UL19-1   Q9UL19-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RARRES3: NX_Q9UL19

Explore proteomics data for RARRES3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RARRES3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004576.2  
    ENSEMBL proteins: 
     ENSP00000402943   ENSP00000255688   ENSP00000346431  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007053 LRAT-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UL19

    ProtoNet protein and cluster: Q9UL19

    1 Blocks protein domain: IPB007053 NC

    UniProtKB/Swiss-Prot: HRSL4_HUMAN, Q9UL19
    Similarity: Belongs to the H-rev107 family


    Find genes that share domains with RARRES3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HRSL4_HUMAN, Q9UL19
    Function: Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various
    phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher
    than PLA2 activity. N- and O-acylation activity is hardly detectable
    Biophysicochemical properties: Kinetic parameters: KM=400 uM for dipalmitoyl-PC; Vmax=530 nmol/min/mg enzyme with
    dipalmitoyl-PC as substrate; Vmax=240 nmol/min/mg enzyme with dipalmitoyl-PE as substrate; pH dependence: Optimum
    pH is 8;
    Induction: By all-trans-retinoic acid and synthetic retinoids

         Enzyme Number (IUBMB): EC 3.1.1.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004623phospholipase A2 activity IDA--
         
    Find genes that share ontologies with RARRES3           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HRSL4_HUMAN, Q9UL19: Membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytoskeleton1
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with RARRES3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RARRES3
    Interactions:

        GeneGlobe Interaction Network for RARRES3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for RARRES3 (Q9UL193 ENSP000002556884) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=2 STRING: ENSP00000309845
    TGM1P227353, ENSP000002067654I2D: score=2 STRING: ENSP00000206765
    TRIM25Q142583, ENSP000003238894I2D: score=1 STRING: ENSP00000323889
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process IDA--
    GO:0008285negative regulation of cell proliferation TAS9843971
    GO:0016042lipid catabolic process IEA--

    Find genes that share ontologies with RARRES3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RARRES3 (HRSL4)

    3 Novoseek inferred chemical compound relationships for RARRES3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoid 76.8 7 10687848 (2), 12879006 (2), 14632211 (2), 9843971 (1)
    retinoic acid 73.9 31 12879006 (8), 10687848 (2), 7974255 (1), 11587209 (1) (see all 13)
    tazarotene 73.6 5 14632211 (3), 9843971 (1)



    Find genes that share compounds with RARRES3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RARRES3 gene: 
    NM_004585.4  

    Unigene Cluster for RARRES3:

    Retinoic acid receptor responder (tazarotene induced) 3
    Hs.17466  [show with all ESTs]
    Unigene Representative Sequence: AK123723
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537871 ENST00000439013 ENST00000255688(uc001nxf.4) ENST00000544107
    ENST00000354445
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RARRES3
      QuantiFast Probe-based Assays in human, mouse, rat RARRES3

    Additional mRNA sequence: 

    AB030815.1 AB453252.1 AF060228.1 AF092922.1 AK123723.1 AK293357.1 AK312110.1 BC009678.1 

    5 DOTS entries:

    DT.213717  DT.101962828  DT.75138203  DT.95324724  DT.91804180 

    Selected AceView cDNA sequences (see all 128):

    AK123723 BI754816 AA976825 H27627 AI560363 BM726379 BM855470 T95003 
    AI090069 BM716729 CA843923 AI884980 AA524750 AA650633 AI245170 BU753908 
    AF060228 BQ445876 BI833083 AI963112 AF092922 BQ639035 BM979683 AB030815 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RARRES3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for RARRES3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RARRES3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCCAGCAG
    RARRES3 Expression
    About this image


    RARRES3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Lung (Respiratory System)
     
     Kidney (Urinary System)
     
     Gall Bladder (Hepatobiliary System)
    RARRES3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RARRES3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.17466

    UniProtKB/Swiss-Prot: HRSL4_HUMAN, Q9UL19
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RARRES3 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia RARRES31 retinoic acid receptor responder (tazarotene induced) more 75.57(n)
    64.6(a)
      483772  XM_005631582.1  XP_005631639.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    43(a)
    40(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    GL343890.1(43623-50178)
    6(38295851-38298037)
    zebrafish
    (Danio rerio)
    Actinopterygii BQ480551.12   -- 75.33(n)    BQ480551.1 


    ENSEMBL Gene Tree for RARRES3 (if available)
    TreeFam Gene Tree for RARRES3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RARRES3 gene
    PLA2G162  HRASLS2  HRASLS22  HRASLS52  
    4 SIMAP similar genes for RARRES3 using alignment to 2 protein entries:     HRSL4_HUMAN (see all proteins):
    HRASLS2    PLA2G16    HRASLS    HRASLS5

    Find genes that share paralogs with RARRES3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RARRES3 (see all 236)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs616812381,2
    C,F--63302305(+) AAGGCA/GTAAAT 1 -- us2k13Minor allele frequency- G:0.15WA 122
    rs1884392811,2
    --63302403(+) GTTGAA/TTGCAG 1 -- us2k10--------
    rs351092551,2
    C,F--63302422(+) GGGGGC/TCCCCT 1 -- us2k16Minor allele frequency- T:0.05MN WA 526
    rs358695051,2
    C,F--63302434(+) AAAGAG/ATTTTG 1 -- us2k15Minor allele frequency- A:0.01MN 408
    rs359511011,2
    C,F--63302453(+) AATATT/CTCAAA 1 -- us2k15Minor allele frequency- C:0.01MN 408
    rs1414827061,2
    C--63302518(+) AAATG-/ATAAA 
     CATAGGT
    ATAAA
    1 -- us2k10--------
    rs359014641,2
    C,F--63302552(+) TAAGAT/GAACAT 1 -- us2k15Minor allele frequency- G:0.01MN 408
    rs1442024211,2
    --63302589(+) CTGATA/GAGAAA 1 -- us2k10--------
    rs1828207071,2
    --63302748(+) TGGAAA/GCTCTG 1 -- us2k10--------
    rs1870623821,2
    --63302758(+) GCCCAA/CACACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RARRES3 (63304273 - 63313934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RARRES3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509417CNV Insertion20534489
    nsv468588CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RARRES3
    DNA2.0 Custom Variant and Variant Library Synthesis for RARRES3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605092    OMIM disorders: --

    1 disease for RARRES3:    
    About MalaCards
    colorectal adenocarcinoma


    Find genes that share disorders with RARRES3           About GenesLikeMe

    7 Novoseek inferred disease relationships for RARRES3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 39 2 10955811 (1), 14632211 (1)
    tumors 24.2 21 15856468 (4), 19615464 (3), 12879006 (2), 9843971 (1) (see all 10)
    adenoma 20 4 12838316 (3), 16426842 (1)
    gastric cancer 18.3 2 10687848 (1), 12014653 (1)
    adenocarcinoma 6.21 5 12838316 (3), 16426842 (1)
    breast cancer 0 15 16080475 (6), 9843971 (1)
    cancer 0 2 9843971 (1), 12879006 (1)

    Genetic Association Database (GAD): RARRES3
    Human Genome Epidemiology (HuGE) Navigator: RARRES3 (4 documents)

    Export disorders for RARRES3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RARRES3 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with RARRES3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. (PubMed id 9843971)1, 2, 9 DiSepio D.... Nagpal S. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells. (PubMed id 10687848)1, 2, 9 Huang S.L.... Jiang S.Y. (Mol. Cell. Endocrinol. 2000)
    3. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PubMed id 19615464)1, 2, 9 Uyama T.... Ueda N. (Biochim. Biophys. Acta 2009)
    4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Molecular mechanisms of tazarotene action in psoriasis. (PubMed id 9270552)1, 3 Duvic M....Chandraratna R.A. (J. Am. Acad. Dermatol. 1997)
    8. Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms. (PubMed id 15856468)1, 9 Lotz K....Sers C. (Int. J. Cancer 2005)
    9. RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. (PubMed id 17196792)1, 9 Tsai F.M....Jiang S.Y. (Cell. Signal. 2007)
    10. Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype. (PubMed id 12879006)1, 9 Higuchi E....Lotan R. (Oncogene 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5920 HGNC: 9869 AceView: RARRES3 Ensembl:ENSG00000133321 euGenes: HUgn5920
    ECgene: RARRES3 H-InvDB: RARRES3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RARRES3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RARRES3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RARRES3 gene:
    Search GeneIP for patents involving RARRES3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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