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RARRES2 Gene

protein-coding   GIFtS: 53
GCID: GC07M150035

Retinoic Acid Receptor Responder (Tazarotene Induced) 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Retinoic Acid Receptor Responder (Tazarotene Induced) 21 2     RAR-Responsive Protein TIG22 3
TIG22 3 5     HP104332
chemerin1 2     Retinoic Acid Receptor Responder Protein 22
Tazarotene-Induced Gene 2 Protein2 3     Chemerin3

External Ids:    HGNC: 98681   Entrez Gene: 59192   Ensembl: ENSG000001065387   OMIM: 6019735   UniProtKB: Q999693   
ORGUL members:         

Export aliases for RARRES2 gene to outside databases

Previous GC identifers: GC07M148282 GC07M149350 GC07M149427 GC07M149473 GC07M149666 GC07M143851


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RARRES2 Gene:
This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled
seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene
and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine,
and is truncated on both termini from the proprotein. (provided by RefSeq, Dec 2008)

GeneCards Summary for RARRES2 Gene:
RARRES2 (retinoic acid receptor responder (tazarotene induced) 2) is a protein-coding gene. Diseases associated with RARRES2 include skin squamous cell carcinoma, and ovarian endometriosis. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot: RARR2_HUMAN, Q99969
Function: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through
activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1
(GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the
expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a
process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an
increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue
metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and
lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory
properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a
chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic
cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by
preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is
mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and
nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic
inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular
disease. Exhibits an antimicrobial function in the skin

Gene Wiki entry for RARRES2 (Chemerin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RARRES2 gene promoter:
         CREB   GATA-3   deltaCREB   MyoD   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRARRES2 promoter sequence
   Search Chromatin IP Primers for RARRES2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RARRES2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

RARRES2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RARRES2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150035:  view genomic region     (about GC identifiers)

Start:
150,035,407 bp from pter      End:
150,038,763 bp from pter
Size:
3,357 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 149,373,258-149,376,614     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RARR2_HUMAN, Q99969 (See protein sequence)
Recommended Name: Retinoic acid receptor responder protein 2 precursor  
Size: 163 amino acids; 18618 Da
Secondary accessions: Q7LE02

Explore the universe of human proteins at neXtProt for RARRES2: NX_Q99969

Explore proteomics data for RARRES2 at MOPED

Post-translational modifications: 

  • Secreted in an inactive precursor form, prochemerin, which is proteolytically processed by a variety of
    extracellular proteases to generate forms with differing levels of bioactivity. For example, the removal of six
    amino acids results in chemerin-157, which exhibits the highest activity, while removal of seven amino acids
    results in chemerin-156 which has slightly less activity. Some proteases are able to cleave at more than one site
    and chemerin forms may be sequentially processed by different enzymes to modulate activity levels. The
    coordinated expression and activity of chemerin-modifying enzymes is essential for regulating its bioactivation,
    inactivation and, consequently, biological function. Cathepsin G cleaves seven C-terminal amino acids from
    prochemerin (chemerin-156), elastase is able to cleave six (chemerin-157), eight (chemerin-155) or eleven
    (chemerin-152), plasmin cleaves five amino acids (chemerin-158), and tryptase cleaves five (chemerin-158) or
    eight (chemerin-155). Multiple cleavages might be required to fully activate chemerin, with an initial tryptase
    cleavage resulting in chemerin with low activity (chemerin-158), and a second cleavage by carboxypeptidase N or B
    producing highly active chemerin (chemerin-157)1
  • Glycosylation2 at Ser157
  • Modification sites at PhosphoSitePlus

  • See RARRES2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002880.1  
    ENSEMBL proteins: 
     ENSP00000223271   ENSP00000417669   ENSP00000418009   ENSP00000418483  

    RARRES2 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for RARRES2
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    ProSpec Recombinant Protein for RARRES2
    Browse Proteins at Cloud-Clone Corp.

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    LSBio Antibodies in human, mouse, rat for RARRES2

    RARRES2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    ProtoNet protein and cluster: Q99969


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RARR2_HUMAN, Q99969
    Function: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through
    activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1
    (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the
    expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a
    process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an
    increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue
    metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and
    lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory
    properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a
    chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic
    cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by
    preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is
    mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and
    nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic
    inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular
    disease. Exhibits an antimicrobial function in the skin
    Induction: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic
    lesions

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI14530373
    GO:0005515protein binding IPI14530373
         
    RARRES2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RARRES2:
     Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rarres2):
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  muscle 

    RARRES2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RARRES2
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    miRTarBase miRNAs that target RARRES2:
    hsa-mir-335-5p (MIRT017042)

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    Sino Biological Human cDNA Clone for RARRES2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RARRES2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RARR2_HUMAN, Q99969: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ISS--
    GO:0031012extracellular matrix IDA19443732

    RARRES2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RARRES2
    Interactions:

        Search GeneGlobe Interaction Network for RARRES2

    2 Interacting proteins for RARRES2 (Q999693) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSKP432353I2D: score=1 
    CTSLP077113I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process IDA9204961
    GO:0001701in utero embryonic development IEP19443732
    GO:0001934positive regulation of protein phosphorylation IDA17635925
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--

    RARRES2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RARRES2 (RARR2)

    7 Novoseek inferred chemical compound relationships for RARRES2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tazarotene 79.2 6 9204961 (3), 14675762 (1), 18971174 (1), 18955196 (1)
    retinoic acid 44.2 6 14675762 (1), 18288381 (1), 19303973 (1), 11342454 (1) (see all 5)
    retinoid 42.9 1 14675762 (1)
    serine 27.7 5 16096270 (3), 17339469 (1), 16863908 (1)
    glucose 25.4 8 19720798 (4), 19233230 (1), 19837789 (1), 20375212 (1) (see all 6)
    calcium 0 3 19841182 (1), 18753310 (1), 14530373 (1)
    cysteine 0 1 14530373 (1)



    RARRES2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RARRES2 gene: 
    NM_002889.3  

    Unigene Cluster for RARRES2:

    Retinoic acid receptor responder (tazarotene induced) 2
    Hs.647064  [show with all ESTs]
    Unigene Representative Sequence: AK092804
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478771 ENST00000223271(uc003wha.3) ENST00000467793 ENST00000466675
    ENST00000482669
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      QuantiFast Probe-based Assays in human, mouse, rat RARRES2

    Additional mRNA sequence: 

    AB015632.1 AK092804.1 AK312197.1 BC000069.2 CR541992.1 CR542026.1 L07329.1 U77594.2 

    9 DOTS entries:

    DT.100700822  DT.100789003  DT.455029  DT.91915612  DT.121069855  DT.95374746  DT.95374749  DT.92029944 
    DT.99977834 

    Selected AceView cDNA sequences (see all 183):

    AA041428 AI141136 CR542026 AV696731 BM707814 CR601678 AA348894 AU100357 
    CR591132 AA057629 AU102320 AA976115 BM919890 BE502307 CR604348 W60662 
    CR616556 BF058939 BE857679 BV202406 BX490481 BI753666 AA041390 BM718120 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RARRES2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                    -     -     -                                                         
    SP2:                    -     -     -                       -     -     -                     
    SP3:              -     -     -     -                                                         
    SP4:                                                                                          
    SP5:                          -     -                                                         


    ECgene alternative splicing isoforms for RARRES2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RARRES2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAATAAAGC
    RARRES2 Expression
    About this image


    RARRES2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Seminiferous Tubules
    RARRES2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RARRES2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647064

    UniProtKB/Swiss-Prot: RARR2_HUMAN, Q99969
    Tissue specificity: Expressed at the highest levels in placenta, liver, and white adipose tissue (WAT), and to a
    lesser extent in many other tissues such as lung, brown adipose tissue, heart, ovary, kidney, skeletal muscle and
    pancreas. Within WAT, expression is enriched in adipocytes as compared to the stromal vascular fraction.
    Expression and secretion increases dramatically with adipogenesis. Highly expressed in skin (basal and suprabasal
    layers of the epidermis, hair follicles and endothelial cells). Expression is elevated in numerous metabolic and
    inflammatory diseases including psoriasis, obesity, type 2 diabetes, metabolic syndrome and cardiovascular
    disease

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RARRES2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RARRES2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rarres21 , 5 retinoic acid receptor responder (tazarotene induced) more1, 5 74.95(n)1
    65.61(a)1
      6 (23.55 cM)5
    716601  NM_027852.21  NP_082128.11 
     485696985 
    chicken
    (Gallus gallus)
    Aves RARRES21 retinoic acid receptor responder (tazarotene induced) more 55.34(n)
    41.83(a)
      420366  NM_001277476.1  NP_001264405.1 


    ENSEMBL Gene Tree for RARRES2 (if available)
    TreeFam Gene Tree for RARRES2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RARRES2 gene

    RARRES2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RARRES2 (see all 11)
    PGOHUM00000238660 PGOHUM00000248855 PGOHUM00000248858 PGOHUM00000259064 PGOHUM00000259065


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RARRES2 (see all 130)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475977251,2
    C--150035766(+) AGAAGC/TTGTGG 2 N S mis10--------
    rs1463457531,2
    C,F--150035788(+) AGCCCA/C/GCTGCA 3 R G W mis11NA 2844
    rs1410330291,2
    C--150035804(+) AGGCAC/GTGGGT 2 H Q mis10--------
    rs790178921,2
    F--150035940(+) CAAACA/GGGCAC 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1816191231,2
    --150035978(+) CTCCTG/TCTTGG 1 -- int10--------
    rs1852178401,2
    --150036010(+) AGCCCA/GTAGGC 1 -- int10--------
    rs2008769361,2
    --150036068(+) GCCCCC/TTCTTA 1 -- int10--------
    rs1381931541,2
    C,F--150036076(+) TTACCC/TGCAGA 2 Q R mis11Minor allele frequency- T:0.00NA 4552
    rs18047641,2
    C,F--150036077(-) TTCTGC/AGGGTA 2 /R syn17Minor allele frequency- A:0.04NS WA CSA NA 4753
    rs2000655591,2
    --150036107(+) GTGGAC/TCAACC 2 I V mis10--------

    HapMap Linkage Disequilibrium report for RARRES2 (150035407 - 150038763 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RARRES2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv435n21CNV Loss19592680
    nsv508490CNV Loss20534489
    nsv521407CNV Loss19592680
    dgv7541n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601973    OMIM disorders: --

    Selected diseases for RARRES2 (see all 33):    
    About MalaCards
    skin squamous cell carcinoma    ovarian endometriosis    peripheral vascular disease    vascular disease
    acute promyelocytic leukemia    endometriosis    insulin resistance    nonalcoholic steatohepatitis
    lupus nephritis    nephritis    crohn's disease    ulcerative colitis
    morbid obesity    obesity    coronary artery disease    osteoarthritis
    psoriasis    fatty liver disease    endotheliitis    diabetes mellitus


    RARRES2 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for RARRES2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 45.7 19 19558533 (4), 19497986 (3), 18809717 (2), 16096270 (1) (see all 10)
    insulin resistance 45.6 8 20375212 (4), 19720798 (4), 19009016 (1)
    obesity 44.7 10 19558533 (3), 19497986 (1), 19698204 (1), 20237162 (1) (see all 7)
    insulin sensitivity 35.3 4 19233230 (1), 19552838 (1), 19720798 (1), 20095887 (1)
    ascites 5.52 3 16863918 (2), 17339469 (1)
    necrosis 0 3 19497986 (1), 19939912 (1), 19052866 (1), 19009016 (1)
    tumors 0 2 19497986 (1), 19052866 (1), 19009016 (1)

    Genetic Association Database (GAD): RARRES2
    Human Genome Epidemiology (HuGE) Navigator: RARRES2 (3 documents)

    Export disorders for RARRES2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RARRES2 gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with RARRES2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chemerin--a new adipokine that modulates adipogenesis via its own receptor. (PubMed id 17767914)1, 2, 3, 9 Roh S.G....Sasaki S. (Biochem. Biophys. Res. Commun. 2007)
    2. Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin. (PubMed id 9204961)1, 2, 9 Nagpal S.... Chandraratna R.A.S. (J. Invest. Dermatol. 1997)
    3. Chemerin, a novel adipokine in the regulation of angiogenesis. (PubMed id 20237162)1, 2, 9 Bozaoglu K....Jowett J.B. (J. Clin. Endocrinol. Metab. 2010)
    4. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. (PubMed id 17635925)1, 2, 9 Goralski K.B....Sinal C.J. (J. Biol. Chem. 2007)
    5. Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. (PubMed id 16096270)1, 2, 9 Zabel B.A....Butcher E.C. (J. Biol. Chem. 2005)
    6. Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23. (PubMed id 14675762)1, 2, 9 Meder W.... Forssmann W.G. (FEBS Lett. 2003)
    7. RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study. (PubMed id 19303973)1, 4, 9 MA1ssig K....HAoring H.U. (Metab. Clin. Exp. 2009)
    8. Chemerin is an antimicrobial agent in human epidermis. (PubMed id 23527010)1, 2 Banas M....Cichy J. (PLoS ONE 2013)
    9. A novel adipocytokine, chemerin exerts anti-inflammatory roles in human vascular endothelial cells. (PubMed id 22634313)1, 2 Yamawaki H....Hara Y. (Biochem. Biophys. Res. Commun. 2012)
    10. Chemerin: a potential endocrine link between obesity and type 2 diabetes. (PubMed id 22610747)1, 2 Roman A.A....Sinal C.J. (Endocrine 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5919 HGNC: 9868 AceView: RARRES2 Ensembl:ENSG00000106538 euGenes: HUgn5919
    ECgene: RARRES2 H-InvDB: RARRES2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RARRES2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RARRES2 gene:
    Search GeneIP for patents involving RARRES2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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