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Aliases for RARRES1 Gene

Aliases for RARRES1 Gene

  • Retinoic Acid Receptor Responder (Tazarotene Induced) 1 2 3
  • TIG1 3 4 6
  • Phorbol Ester-Induced Gene 1 Protein 3 4
  • Tazarotene-Induced Gene 1 Protein 3 4
  • RAR-Responsive Protein TIG1 3 4
  • Latexin-Like 2 3
  • PERG-1 3 4
  • Retinoic Acid Receptor Responder Protein 1 3
  • PEIG1 4
  • LXNL 3

External Ids for RARRES1 Gene

Previous GeneCards Identifiers for RARRES1 Gene

  • GC03M155675
  • GC03M159362
  • GC03M159696
  • GC03M159735
  • GC03M159897
  • GC03M158414
  • GC03M155810

Summaries for RARRES1 Gene

Entrez Gene Summary for RARRES1 Gene

  • This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for RARRES1 Gene

RARRES1 (Retinoic Acid Receptor Responder (Tazarotene Induced) 1) is a Protein Coding gene. Diseases associated with RARRES1 include prostate cancer. An important paralog of this gene is LXN.

UniProtKB/Swiss-Prot for RARRES1 Gene

  • Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.

Gene Wiki entry for RARRES1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RARRES1 Gene

Genomics for RARRES1 Gene

Regulatory Elements for RARRES1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RARRES1 Gene

Start:
158,696,892 bp from pter
End:
158,732,853 bp from pter
Size:
35,962 bases
Orientation:
Minus strand

Genomic View for RARRES1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RARRES1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RARRES1 Gene

Proteins for RARRES1 Gene

  • Protein details for RARRES1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49788-TIG1_HUMAN
    Recommended name:
    Retinoic acid receptor responder protein 1
    Protein Accession:
    P49788
    Secondary Accessions:
    • Q8N1D7

    Protein attributes for RARRES1 Gene

    Size:
    294 amino acids
    Molecular mass:
    33285 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RARRES1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RARRES1 Gene

Proteomics data for RARRES1 Gene at MOPED

Post-translational modifications for RARRES1 Gene

Other Protein References for RARRES1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RARRES1 Gene

Domains for RARRES1 Gene

Protein Domains for RARRES1 Gene

Suggested Antigen Peptide Sequences for RARRES1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49788

UniProtKB/Swiss-Prot:

TIG1_HUMAN :
  • P49788
Family:
  • Belongs to the protease inhibitor I47 (latexin) family.
genes like me logo Genes that share domains with RARRES1: view

No data available for Gene Families for RARRES1 Gene

Function for RARRES1 Gene

Molecular function for RARRES1 Gene

UniProtKB/Swiss-Prot Function: Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.
UniProtKB/Swiss-Prot Induction: By tazarotene and by all the retinoic acid receptors tested

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RARRES1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RARRES1 Gene

Localization for RARRES1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RARRES1 Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RARRES1 Gene COMPARTMENTS Subcellular localization image for RARRES1 gene
Compartment Confidence
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RARRES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with RARRES1: view

Pathways for RARRES1 Gene

SuperPathways for RARRES1 Gene

No Data Available

Interacting Proteins for RARRES1 Gene

Gene Ontology (GO) - Biological Process for RARRES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with RARRES1: view

No data available for Pathways by source for RARRES1 Gene

Compounds for RARRES1 Gene

(1) HMDB Compounds for RARRES1 Gene

Compound Synonyms Cas Number PubMed IDs
Retinoic acid
  • Retinoate
302-79-4

(1) Drugbank Compounds for RARRES1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Tretinoin
  • All Trans Retinoic Acid
302-79-4 target agonist

(3) Novoseek inferred chemical compound relationships for RARRES1 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 67.8 11
retinoid 64.1 5
cysteine 19.7 1
genes like me logo Genes that share compounds with RARRES1: view

Transcripts for RARRES1 Gene

Unigene Clusters for RARRES1 Gene

Retinoic acid receptor responder (tazarotene induced) 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RARRES1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RARRES1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: -
SP2:
SP3: - - -
SP4: -

Relevant External Links for RARRES1 Gene

GeneLoc Exon Structure for
RARRES1
ECgene alternative splicing isoforms for
RARRES1

Expression for RARRES1 Gene

mRNA expression in normal human tissues for RARRES1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RARRES1 Gene

This gene is overexpressed in Minor Salivary Gland (5.5), Fallopian Tube (5.1), Adipose - Visceral (Omentum) (4.9), and Heart - Atrial Appendage (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RARRES1 Gene

SOURCE GeneReport for Unigene cluster for RARRES1 Gene Hs.131269

genes like me logo Genes that share expressions with RARRES1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RARRES1 Gene

Orthologs for RARRES1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RARRES1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RARRES1 35
  • 88.96 (n)
  • 84.64 (a)
RARRES1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RARRES1 35
  • 79.75 (n)
  • 70.14 (a)
RARRES1 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RARRES1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rarres1 35
  • 79.86 (n)
  • 77.55 (a)
Rarres1 16
Rarres1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RARRES1 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rarres1 35
  • 81.36 (n)
  • 77.55 (a)
chicken
(Gallus gallus)
Aves RARRES1 35
  • 53.53 (n)
  • 36.44 (a)
RARRES1 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RARRES1 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rarres1 35
  • 55.16 (n)
  • 42.48 (a)
zebrafish
(Danio rerio)
Actinopterygii lxn 36
  • 22 (a)
OneToMany
Species with no ortholog for RARRES1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RARRES1 Gene

ENSEMBL:
Gene Tree for RARRES1 (if available)
TreeFam:
Gene Tree for RARRES1 (if available)

Paralogs for RARRES1 Gene

Paralogs for RARRES1 Gene

Selected SIMAP similar genes for RARRES1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RARRES1: view

Variants for RARRES1 Gene

Sequence variations from dbSNP and Humsavar for RARRES1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs10276 -- 158,697,377(-) AATCA(A/C/G)CATTT utr-variant-3-prime
rs1012287 -- 158,696,845(+) ACAGT(A/T)TGTAC downstream-variant-500B
rs1051109 -- 158,697,555(-) CAAGT(A/G)AAAAC utr-variant-3-prime
rs1063135 -- 158,710,792(-) ACCTG(C/T)TTTAC reference, missense
rs1271320 -- 158,704,125(-) tggca(A/G)attga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RARRES1 Gene

Variant ID Type Subtype PubMed ID
nsv877692 CNV Loss 21882294

Relevant External Links for RARRES1 Gene

HapMap Linkage Disequilibrium report
RARRES1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RARRES1 Gene

Disorders for RARRES1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RARRES1 Gene including...

Search for RARRES1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for RARRES1 Gene

Disease -log(P) Hits PubMed IDs
tumors 24.1 9

Relevant External Links for RARRES1

Genetic Association Database (GAD)
RARRES1
Human Genome Epidemiology (HuGE) Navigator
RARRES1
genes like me logo Genes that share disorders with RARRES1: view

No data available for UniProtKB/Swiss-Prot for RARRES1 Gene

Publications for RARRES1 Gene

  1. Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor- responsive gene in skin. (PMID: 8601727) Nagpal S. … Chandraratna R.A.S. (J. Invest. Dermatol. 1996) 2 3 4 23
  2. Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity. (PMID: 11929948) Jing C. … Ke Y. (J. Natl. Cancer Inst. 2002) 3 23
  3. DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage. (PMID: 16128742) Mizuiri H. … Yasui W. (Cancer Sci. 2005) 3 23
  4. DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation. (PMID: 16134180) Shutoh M. … Yasui W. (Cancer 2005) 3 23
  5. Involvement of tazarotene-induced gene 1 in proliferation and differentiation of human adipose tissue-derived mesenchymal stem cells. (PMID: 19250291) Ohnishi S. … Nagaya N. (Cell Prolif. 2009) 3 23

Products for RARRES1 Gene

Sources for RARRES1 Gene

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