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Aliases for RARRES1 Gene

Aliases for RARRES1 Gene

  • Retinoic Acid Receptor Responder 1 2 3
  • Retinoic Acid Receptor Responder (Tazarotene Induced) 1 2 3 5
  • Phorbol Ester-Induced Gene 1 Protein 3 4
  • Tazarotene-Induced Gene 1 Protein 3 4
  • RAR-Responsive Protein TIG1 3 4
  • Latexin-Like 2 3
  • PERG-1 3 4
  • TIG1 3 4
  • PEIG1 4
  • LXNL 3

External Ids for RARRES1 Gene

Previous GeneCards Identifiers for RARRES1 Gene

  • GC03M155675
  • GC03M159362
  • GC03M159696
  • GC03M159735
  • GC03M159897
  • GC03M158414
  • GC03M155810

Summaries for RARRES1 Gene

Entrez Gene Summary for RARRES1 Gene

  • This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for RARRES1 Gene

RARRES1 (Retinoic Acid Receptor Responder 1) is a Protein Coding gene. An important paralog of this gene is LXN.

UniProtKB/Swiss-Prot for RARRES1 Gene

  • Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.

Gene Wiki entry for RARRES1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RARRES1 Gene

Genomics for RARRES1 Gene

Regulatory Elements for RARRES1 Gene

Enhancers for RARRES1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RARRES1 on UCSC Golden Path with GeneCards custom track

Promoters for RARRES1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RARRES1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RARRES1 Gene

Chromosome:
3
Start:
158,696,892 bp from pter
End:
158,732,696 bp from pter
Size:
35,805 bases
Orientation:
Minus strand

Genomic View for RARRES1 Gene

Genes around RARRES1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RARRES1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RARRES1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RARRES1 Gene

Proteins for RARRES1 Gene

  • Protein details for RARRES1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49788-TIG1_HUMAN
    Recommended name:
    Retinoic acid receptor responder protein 1
    Protein Accession:
    P49788
    Secondary Accessions:
    • Q8N1D7

    Protein attributes for RARRES1 Gene

    Size:
    294 amino acids
    Molecular mass:
    33285 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RARRES1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RARRES1 Gene

Proteomics data for RARRES1 Gene at MOPED

Post-translational modifications for RARRES1 Gene

Other Protein References for RARRES1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RARRES1 Gene

Domains & Families for RARRES1 Gene

Protein Domains for RARRES1 Gene

Suggested Antigen Peptide Sequences for RARRES1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49788

UniProtKB/Swiss-Prot:

TIG1_HUMAN :
  • Belongs to the protease inhibitor I47 (latexin) family.
Family:
  • Belongs to the protease inhibitor I47 (latexin) family.
genes like me logo Genes that share domains with RARRES1: view

No data available for Gene Families for RARRES1 Gene

Function for RARRES1 Gene

Molecular function for RARRES1 Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.
UniProtKB/Swiss-Prot Induction:
By tazarotene and by all the retinoic acid receptors tested.
genes like me logo Genes that share phenotypes with RARRES1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RARRES1 Gene

Localization for RARRES1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RARRES1 Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RARRES1 Gene COMPARTMENTS Subcellular localization image for RARRES1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RARRES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with RARRES1: view

Pathways & Interactions for RARRES1 Gene

SuperPathways for RARRES1 Gene

No Data Available

Interacting Proteins for RARRES1 Gene

Gene Ontology (GO) - Biological Process for RARRES1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RARRES1 Gene

Drugs & Compounds for RARRES1 Gene

(2) Drugs for RARRES1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, binder, Target, agonist 215

(2) Additional Compounds for RARRES1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RARRES1: view

Transcripts for RARRES1 Gene

Unigene Clusters for RARRES1 Gene

Retinoic acid receptor responder (tazarotene induced) 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RARRES1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: -
SP2:
SP3: - - -
SP4: -

Relevant External Links for RARRES1 Gene

GeneLoc Exon Structure for
RARRES1
ECgene alternative splicing isoforms for
RARRES1

Expression for RARRES1 Gene

mRNA expression in normal human tissues for RARRES1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RARRES1 Gene

This gene is overexpressed in Minor Salivary Gland (x5.5), Fallopian Tube (x5.1), Adipose - Visceral (Omentum) (x4.9), and Heart - Atrial Appendage (x4.5).

Protein differential expression in normal tissues from HIPED for RARRES1 Gene

This gene is overexpressed in Amniocyte (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RARRES1 Gene



SOURCE GeneReport for Unigene cluster for RARRES1 Gene Hs.131269

genes like me logo Genes that share expression patterns with RARRES1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RARRES1 Gene

Orthologs for RARRES1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RARRES1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RARRES1 35
  • 79.75 (n)
  • 70.14 (a)
RARRES1 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rarres1 35
  • 79.86 (n)
  • 77.55 (a)
Rarres1 16
Rarres1 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RARRES1 35
  • 88.96 (n)
  • 84.64 (a)
RARRES1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rarres1 35
  • 81.36 (n)
  • 77.55 (a)
dog
(Canis familiaris)
Mammalia RARRES1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RARRES1 36
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves RARRES1 35
  • 53.53 (n)
  • 36.44 (a)
RARRES1 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RARRES1 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rarres1 35
  • 55.16 (n)
  • 42.48 (a)
zebrafish
(Danio rerio)
Actinopterygii lxn 36
  • 22 (a)
OneToMany
Species with no ortholog for RARRES1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RARRES1 Gene

ENSEMBL:
Gene Tree for RARRES1 (if available)
TreeFam:
Gene Tree for RARRES1 (if available)

Paralogs for RARRES1 Gene

Paralogs for RARRES1 Gene

(1) SIMAP similar genes for RARRES1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RARRES1: view

Variants for RARRES1 Gene

Sequence variations from dbSNP and Humsavar for RARRES1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11919919 - 158,710,800(+) GGTAA(A/T)CCTCT reference, missense
VAR_060094 -
rs10276 -- 158,697,377(-) AATCA(A/C/G)CATTT utr-variant-3-prime
rs1051109 -- 158,697,555(-) CAAGT(A/G)AAAAC utr-variant-3-prime
rs1063135 -- 158,710,792(+) ACCTG(A/C/G/T)TTTAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RARRES1 Gene

Variant ID Type Subtype PubMed ID
nsv877692 CNV Loss 21882294

Variation tolerance for RARRES1 Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RARRES1 Gene

Disorders for RARRES1 Gene

Relevant External Links for RARRES1

Genetic Association Database (GAD)
RARRES1
Human Genome Epidemiology (HuGE) Navigator
RARRES1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RARRES1

No disorders were found for RARRES1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RARRES1 Gene

Publications for RARRES1 Gene

  1. Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor- responsive gene in skin. (PMID: 8601727) Nagpal S. … Chandraratna R.A.S. (J. Invest. Dermatol. 1996) 2 3 4 23 67
  2. Involvement of tazarotene-induced gene 1 in proliferation and differentiation of human adipose tissue-derived mesenchymal stem cells. (PMID: 19250291) Ohnishi S. … Nagaya N. (Cell Prolif. 2009) 3 23
  3. DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage. (PMID: 16128742) Mizuiri H. … Yasui W. (Cancer Sci. 2005) 3 23
  4. DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation. (PMID: 16134180) Shutoh M. … Yasui W. (Cancer 2005) 3 23
  5. Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers. (PMID: 15059893) Youssef E.M. … Issa J.P. (Cancer Res. 2004) 3 25

Products for RARRES1 Gene

Sources for RARRES1 Gene

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