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Aliases for RARG Gene

Aliases for RARG Gene

  • Retinoic Acid Receptor, Gamma 2 3
  • Nuclear Receptor Subfamily 1 Group B Member 3 3 4
  • RAR-Gamma 3 4
  • NR1B3 3 4
  • Retinoic Acid Nuclear Receptor Gamma Variant 1 3
  • Retinoic Acid Nuclear Receptor Gamma Variant 2 3
  • Retinoic Acid Receptor Gamma 3
  • RARC 3

External Ids for RARG Gene

Previous GeneCards Identifiers for RARG Gene

  • GC12M053763
  • GC12M053518
  • GC12M053321
  • GC12M051890
  • GC12M053604
  • GC12M050646

Summaries for RARG Gene

Entrez Gene Summary for RARG Gene

  • This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for RARG Gene

RARG (Retinoic Acid Receptor, Gamma) is a Protein Coding gene. Diseases associated with RARG include exfoliative ichthyosis. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and steroid hormone receptor activity. An important paralog of this gene is NR1I2.

UniProtKB/Swiss-Prot for RARG Gene

  • Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Tocris Summary for RARG Gene

  • Retinoic acid receptors (RARs) are nuclear hormone receptors of the NRB1 class, which function as heterodimers with retinoid X receptors (RXRs). There are three distinct RAR subtypes; RARalpha, RARbeta and RARgamma. RARalpha is present in most tissue types, whereas RARbeta and RARgamma expression is more selective. RXR-RAR heterodimers act as ligand-dependent transcriptional regulators by binding to the specific retinoic acid response element (RARE) found in the promoter regions of target genes. In the absence of an RAR agonist, RXR-RAR recruits co-repressor proteins such as NCoR and associated factors such as histone deacetylase to maintain a condensed chromatin structure. RAR agonist binding stimulates co-repressor release and co-activator complexes, such as histone acetyltransferase, are recruited to activate transcription. RARs transduce retinoid signals in vivo, which mediates proper embryogenesis, differentiation and growth arrest. Specifically, RXRalpha-RARgamma heterodimers are necessary for growth arrest and viseral and primitive endodermal differentiation, whereas RXRalpha-RARalpha is required for cAMP-dependent parietal endodermal differentiation. In vitro it has been difficult to elucidate the roles of individual subtypes as functional RAR knockouts generate artificial redundancies that are thought not to exist under normal conditions.

Gene Wiki entry for RARG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RARG Gene

Genomics for RARG Gene

Regulatory Elements for RARG Gene

Genomic Location for RARG Gene

Start:
53,210,566 bp from pter
End:
53,232,980 bp from pter
Size:
22,415 bases
Orientation:
Minus strand

Genomic View for RARG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RARG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RARG Gene

Proteins for RARG Gene

  • Protein details for RARG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13631-RARG_HUMAN
    Recommended name:
    Retinoic acid receptor gamma
    Protein Accession:
    P13631
    Secondary Accessions:
    • B7Z492
    • B7Z4F1
    • B7ZAE4
    • J3KNP6
    • P22932
    • Q15281
    • Q52LZ8
    • Q9BYX8
    • Q9H1I3
    • Q9UJ38

    Protein attributes for RARG Gene

    Size:
    454 amino acids
    Molecular mass:
    50342 Da
    Quaternary structure:
    • Homodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus.
    SequenceCaution:
    • Sequence=CAA40548.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RARG Gene

    Alternative splice isoforms for RARG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RARG Gene

Proteomics data for RARG Gene at MOPED

Post-translational modifications for RARG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RARG Gene

Domains for RARG Gene

Gene Families for RARG Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P13631

UniProtKB/Swiss-Prot:

RARG_HUMAN :
  • P13631
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with RARG: view

Function for RARG Gene

Molecular function for RARG Gene

GENATLAS Biochemistry: retinoic acid receptor binding and activated by both all-trans (T-RA) and its 9-cis isomer (9-cis-RA) retinoic acids,gamma subunit,steroid/thyroid hormone receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Gene Ontology (GO) - Molecular Function for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0003677 DNA binding ISS --
GO:0003700 sequence-specific DNA binding transcription factor activity ISS --
GO:0003707 steroid hormone receptor activity IEA --
GO:0003708 retinoic acid receptor activity IEA --
genes like me logo Genes that share ontologies with RARG: view
genes like me logo Genes that share phenotypes with RARG: view

Animal Models for RARG Gene

MGI Knock Outs for RARG:

miRNA for RARG Gene

Targeting motifs for RARG Gene
HOMER Transcription Factor Regulatory Elements motif RARG
  • Consensus sequence: AGGTCAAGGTCA Submotif: canonical Cell Type: ES GeoId: GSE30538

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for RARG Gene

Localization for RARG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RARG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RARG Gene COMPARTMENTS Subcellular localization image for RARG gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex ISS --
GO:0016021 integral component of membrane NAS 17943189
genes like me logo Genes that share ontologies with RARG: view

Pathways for RARG Gene

genes like me logo Genes that share pathways with RARG: view

Gene Ontology (GO) - Biological Process for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001843 neural tube closure IEA --
GO:0002063 chondrocyte development --
GO:0002068 glandular epithelial cell development IEA --
GO:0003406 retinal pigment epithelium development IEA --
genes like me logo Genes that share ontologies with RARG: view

Compounds for RARG Gene

(5) Tocris Compounds for RARG Gene

Compound Action Cas Number
AM 580 Retinoic acid analog; RARalpha agonist [102121-60-8]
BMS 493 Pan-RAR inverse agonist [215030-90-3]
CD 2665 Selective RARbeta/gamma antagonist [170355-78-9]
Liarozole hydrochloride Blocks retinoic acid metabolism [145858-50-0]
Retinoic acid Endogenous retinoic acid receptor agonist [302-79-4]

(1) HMDB Compounds for RARG Gene

Compound Synonyms Cas Number PubMed IDs
Retinoic acid
  • Retinoate
302-79-4

(13) Drugbank Compounds for RARG Gene

(10) IUPHAR Ligand for RARG Gene

Ligand Type Action Affinity Pubmed IDs
9-cis-retinoic acid Agonist Agonist 9.7
all-trans-retinoic acid Agonist Agonist 9.4
AGN193109 Antagonist Inverse agonist 8.7
BMS493 Antagonist Inverse agonist 8.54
TTNPB Agonist Agonist 8
CD2665 Antagonist Antagonist 7.1
BMS270394 Agonist Agonist 6.3
CD666 Agonist Agonist 5.64
AHPN Agonist Agonist
MM 11253 Antagonist Antagonist

(8) Novoseek inferred chemical compound relationships for RARG Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 89.4 120
retinoid 84.5 11
cd 437 80.2 1
ttnpb 67.9 1
vitamin a 54.5 1
genes like me logo Genes that share compounds with RARG: view

Transcripts for RARG Gene

Unigene Clusters for RARG Gene

Retinoic acid receptor, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RARG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9: - - - - - - - -
SP10: - - - - -
SP11: - - - - - -
SP12:
SP13:
SP14:

ExUns: 11 ^ 12 ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for RARG Gene

GeneLoc Exon Structure for
RARG
ECgene alternative splicing isoforms for
RARG

Expression for RARG Gene

mRNA expression in normal human tissues for RARG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RARG Gene

This gene is overexpressed in Esophagus - Mucosa (6.4), Skin - Sun Exposed (Lower leg) (5.0), and Skin - Not Sun Exposed (Suprapubic) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RARG Gene

SOURCE GeneReport for Unigene cluster for RARG Gene Hs.1497

genes like me logo Genes that share expressions with RARG: view

No data available for mRNA Expression by UniProt/SwissProt for RARG Gene

Orthologs for RARG Gene

This gene was present in the common ancestor of animals.

Orthologs for RARG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RARG 35
  • 99.56 (n)
  • 100 (a)
RARG 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RARG 35
  • 93.29 (n)
  • 98.67 (a)
RARG 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RARG 35
  • 93.52 (n)
  • 98.45 (a)
RARG 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rarg 35
  • 89.9 (n)
  • 98.89 (a)
Rarg 16
Rarg 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RARG 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rarg 35
  • 89.16 (n)
  • 98 (a)
lizard
(Anolis carolinensis)
Reptilia RARG 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485387 35
  • 73.19 (n)
  • 84.89 (a)
zebrafish
(Danio rerio)
Actinopterygii rarga 36
  • 73 (a)
OneToMany
rargb 35
  • 79.16 (n)
  • 88.63 (a)
rargb 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eip75B 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea sex-1 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8261 36
  • 38 (a)
OneToMany
Species with no ortholog for RARG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RARG Gene

ENSEMBL:
Gene Tree for RARG (if available)
TreeFam:
Gene Tree for RARG (if available)

Paralogs for RARG Gene

genes like me logo Genes that share paralogs with RARG: view

Variants for RARG Gene

Sequence variations from dbSNP and Humsavar for RARG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs941138 -- 53,220,565(+) AAATA(C/T)GCAAG intron-variant, upstream-variant-2KB
rs941139 -- 53,220,726(+) TTGGA(A/G)GAAGG intron-variant, upstream-variant-2KB
rs1042492 -- 53,215,754(-) GTGCC(A/C)AGCTC synonymous-codon, reference, intron-variant
rs1042493 -- 53,211,281(-) AAGGG(C/G)ACAAA utr-variant-3-prime
rs1042494 -- 53,211,156(-) GGGCA(A/G)GCTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RARG Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680
nsv832417 CNV Gain 17160897
nsv470295 CNV Gain 18288195
nsv469404 CNV Loss 19166990

Relevant External Links for RARG Gene

HapMap Linkage Disequilibrium report
RARG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RARG Gene

Disorders for RARG Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RARG Gene including...

Search for RARG Gene in MalaCards »

(11) Novoseek inferred disease relationships for RARG Gene

Disease -log(P) Hits PubMed IDs
carcinoma embryonal 67.3 2
teratocarcinoma 49.9 1
pancreatic carcinoma 40.4 1
premalignant 14.4 1
carcinoma squamous cell 11.2 3

Relevant External Links for RARG

Genetic Association Database (GAD)
RARG
Human Genome Epidemiology (HuGE) Navigator
RARG
genes like me logo Genes that share disorders with RARG: view

No data available for UniProtKB/Swiss-Prot for RARG Gene

Publications for RARG Gene

  1. Genomic organization of the retinoic acid receptor gamma gene. (PMID: 1849262) Lehmann J.M. … Pfahl M. (Nucleic Acids Res. 1991) 2 3 4 23
  2. Murine isoforms of retinoic acid receptor gamma with specific patterns of expression. (PMID: 2157210) Kastner P. … Chambon P. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 23
  3. A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation. (PMID: 15383624) Yen A. … Varvayanis S. (Mol. Pharmacol. 2004) 3 23
  4. Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax. (PMID: 12189556) Pettersson F. … Colston K.W. (Br. J. Cancer 2002) 3 23
  5. Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma. (PMID: 9852056) Zhang Z.P. … Soprano D.R. (J. Biol. Chem. 1998) 3 23

Products for RARG Gene

Sources for RARG Gene

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