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RARG Gene

protein-coding   GIFtS: 69
GCID: GC12M053604

Retinoic Acid Receptor, Gamma

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Retinoic Acid Receptor, Gamma1 2     RARC2
Nuclear Receptor Subfamily 1 Group B Member 32 3     Retinoic Acid Nuclear Receptor Gamma Variant 12
NR1B32 3     Retinoic Acid Nuclear Receptor Gamma Variant 22
RAR-gamma2 3     Retinoic Acid Receptor Gamma2

External Ids:    HGNC: 98661   Entrez Gene: 59162   Ensembl: ENSG000001728197   OMIM: 1801905   UniProtKB: P136313   

Export aliases for RARG gene to outside databases

Previous GC identifers: GC12M053763 GC12M053518 GC12M053321 GC12M051890 GC12M050646


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RARG Gene:
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid
receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate
transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter
regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are
involved in various biological processes, including limb bud development, skeletal growth, and matrix
homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Aug 2011)

GeneCards Summary for RARG Gene:
RARG (retinoic acid receptor, gamma) is a protein-coding gene. Diseases associated with RARG include hepatopulmonary syndrome, and teratocarcinoma. GO annotations related to this gene include steroid hormone receptor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is VDR.

UniProtKB/Swiss-Prot: RARG_HUMAN, P13631
Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response
elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various
biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of
tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene
expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB,
required for skeletal growth, matrix homeostasis and growth plate function (By similarity)

summary for RARG Gene:
Retinoic acid receptors (RARs) are nuclear hormone receptors of the NRB1 class, which function as
heterodimers with retinoid X receptors (RXRs). There are three distinct RAR subtypes; RARalpha, RARbeta and
RARgamma. RARalpha is present in most tissue types, whereas RARbeta and RARgamma expression is more
selective. RXR-RAR heterodimers act as ligand-dependent transcriptional regulators by binding to the
specific retinoic acid response element (RARE) found in the promoter regions of target genes. In the absence
of an RAR agonist, RXR-RAR recruits co-repressor proteins such as NCoR and associated factors such as
histone deacetylase to maintain a condensed chromatin structure. RAR agonist binding stimulates co-repressor
release and co-activator complexes, such as histone acetyltransferase, are recruited to activate
transcription. RARs transduce retinoid signals in vivo, which mediates proper embryogenesis, differentiation
and growth arrest. Specifically, RXRalpha-RARgamma heterodimers are necessary for growth arrest and viseral
and primitive endodermal differentiation, whereas RXRalpha-RARalpha is required for cAMP-dependent parietal
endodermal differentiation. In vitro it has been difficult to elucidate the roles of individual subtypes as
functional RAR knockouts generate artificial redundancies that are thought not to exist under normal
conditions.

Gene Wiki entry for RARG (Retinoic acid receptor gamma) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RARG gene promoter:
         PPAR-gamma1   p300   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RARG promoter sequence
   Search Chromatin IP Primers for RARG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RARG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

RARG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RARG gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053604:  view genomic region     (about GC identifiers)

Start:
53,604,353 bp from pter      End:
53,626,764 bp from pter
Size:
22,412 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RARG_HUMAN, P13631 (See protein sequence)
Recommended Name: Retinoic acid receptor gamma  
Size: 454 amino acids; 50342 Da
Subunit: Homodimer (By similarity). Heterodimer with a RXR molecule (By similarity). Binds DNA preferentially as a
RAR/RXR heterodimer (By similarity). Forms a complex with PUS1 and the SRA1 RNA in the nucleus (By similarity)
Sequence caution: Sequence=CAA40548.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for RARG (see all 9):
1EXA (3D)        1EXX (3D)        1FCX (3D)        1FCY (3D)        1FCZ (3D)        1FD0 (3D)    
Secondary accessions: B7Z492 B7Z4F1 B7ZAE4 J3KNP6 P22932 Q15281 Q52LZ8 Q9BYX8 Q9H1I3 Q9UJ38
Alternative splicing: 4 isoforms:  P13631-1   P13631-2   P13631-3   P13631-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RARG: NX_P13631

Explore proteomics data for RARG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RARG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000957.1  NP_001036193.1  NP_001230659.1  NP_001230660.1  NP_001230661.1  

    ENSEMBL proteins: 
     ENSP00000388510   ENSP00000343698   ENSP00000444335   ENSP00000454417   ENSP00000454604  
     ENSP00000454385   ENSP00000377947   ENSP00000332695  
    Reactome Protein details: P13631

    RARG Human Recombinant Protein Products:

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    Novus Biologicals RARG Proteins
    Novus Biologicals RARG Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    RARG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cell Signaling Technology (CST) Antibodies for RARG 
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    RARG Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Retinoic acid receptor-gamma
    1B. Retinoic acid receptors

    Selected InterPro protein domains (see all 6):
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR001723 Str_hrmn_rcpt
     IPR003078 Retinoic_acid_rcpt
     IPR013088 Znf_NHR/GATA
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core

    Graphical View of Domain Structure for InterPro Entry P13631

    ProtoNet protein and cluster: P13631

    2 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003078 Retinoic acid receptor (1B nuclear receptor) signature


    UniProtKB/Swiss-Prot: RARG_HUMAN, P13631
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal
    ligand-binding domain
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    RARG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RARG_HUMAN, P13631
    Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response
    elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various
    biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of
    tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene
    expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB,
    required for skeletal growth, matrix homeostasis and growth plate function (By similarity)

         Genatlas biochemistry entry for RARG:
    retinoic acid receptor binding and activated by both all-trans (T-RA) and its 9-cis isomer (9-cis-RA) retinoic
    acids,gamma subunit,steroid/thyroid hormone receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003708retinoic acid receptor activity IEA--
    GO:0005515protein binding IPI10428834
         
    RARG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RARG:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Rarg) (see all 19):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system  normal  renal/urinary system 

    RARG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RARG: Rargtm1Blt Rargtm2Ipc Rargtm1Ipc Rargtm3.1Ipc Rargtm4Ipc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RARG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RARG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RARG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RARG

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AGGTCAAGGTCA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RARG:
    hsa-mir-335-5p (MIRT017251), hsa-mir-182-5p (MIRT001222), hsa-mir-320c (MIRT036166), hsa-mir-124-3p (MIRT002564)

    Block miRNA regulation of human, mouse, rat RARG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RARG (see all 59):
    hsa-miR-596 hsa-miR-4254 hsa-miR-330-5p hsa-miR-765 hsa-miR-30d hsa-miR-507 hsa-miR-764 hsa-miR-3667-5p
    SwitchGear 3'UTR luciferase reporter plasmidRARG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RARG
    Predesigned siRNA for gene silencing in human, mouse, rat RARG

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for RARG

    Clone
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    OriGene clones in human, mouse for RARG (see all 12)
    OriGene ORF clones in mouse, rat for RARG
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    GenScript: all cDNA clones in your preferred vector (see all 2): RARG (NM_000966)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RARG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RARG_HUMAN, P13631: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0016021integral component of membrane NAS17943189

    RARG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RARG About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2PEDF Induced Signaling
    all-trans-Retinoic Acid Signaling in Brain0.71
    RAR-Gamma-RXR-Alpha Degradation0.62
    3Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    4Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RARG
        Nuclear Receptor Activation by Vitamin-A
    Molecular Mechanisms of Cancer
    all-trans-Retinoic Acid Signaling in Brain
    all-trans-Retinoic Acid Mediated Apoptosis
    RAR-Gamma-RXR-Alpha Degradation

    3 BioSystems Pathways for RARG
        Nuclear Receptors
    Vitamin A and carotenoid metabolism
    Nuclear receptors in lipid metabolism and toxicity

    1 Reactome Pathway for RARG
        Nuclear Receptor transcription pathway



    RARG for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RARG: 
              Nuclear Receptors & Coregulators in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RARG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RARG (P136311, 2, 3 ENSP000003326954) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206289P287023I2D: score=3 
    ENSG00000227322P287023I2D: score=3 
    ENSG00000228333P287023I2D: score=3 
    ENSG00000231321P287023I2D: score=3 
    ENSG00000235712P287023I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0002063chondrocyte development ----
    GO:0003417growth plate cartilage development ----
    GO:0003430growth plate cartilage chondrocyte growth IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    RARG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RARG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Liarozole hydrochlorideBlocks retinoic acid metabolism[145858-50-0]
    BMS 195614Selective RARalpha antagonist[253310-42-8]
    FenretinideSynthetic retinoid. Potent anticancer agent[65646-68-6]
    BMS 493Pan-RAR inverse agonist[215030-90-3]
    CD 1530Potent and selective RARgamma agonist[107430-66-0]

    1 HMDB Compound for RARG    About this table
    CompoundSynonyms CAS #PubMed Ids
    Retinoic acidRetinoate (see all 21)302-79-4--

    Selected DrugBank Compounds for RARG (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TretinoinAll Trans Retinoic Acid (see all 5)302-79-4targetagonist1332684 17139284 8394693 10792999 11752352 17016423 10592235
    Alitretinoin9-cis-Retinoic acid (see all 4)5300-03-8targetagonist19678713 17277115 16880407 16788091 10592235
    Tazarotene-- 118292-40-3targetagonist17139284 18034539 11752352 17016423 10592235
    4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid-- --target--17139284 17016423 10592235
    Acitretin-- 55079-83-9targetagonist17139284 17016423 10592235
    AdapaleneAdapaleno [INN-Spanish] (see all 2)106685-40-9targetagonist17139284 17016423 10592235
    BMS184394-- --target--17139284 17016423 10592235
    CD564-- --target--17139284 17016423 10592235
    Dodecyl-Alpha-D-Maltoside-- --target--17139284 17016423 10592235
    Etretinate-- 54350-48-0targetagonist17139284 17016423 10592235

    10 IUPHAR Ligands for RARG (Retinoic acid receptor-gamma)    About this table
    LigandTypeActionAffinityPubmed IDs
    all-trans-retinoic acid
    AgonistAgonist9.68380496 8264595 10964567 7791761 10637371
    9-cis-retinoic acid
    AgonistAgonist97791761 10964567
    AGN193109
    AntagonistAntagonist8.510777502 10637371 8798442
    TTNPB
    AgonistAgonist7.828264595 10964567
    CD666
    AgonistAgonist7.171323296
    CD2665
    AntagonistAntagonist7.19187263
    BMS493
    AntagonistAntagonist711805839
    BMS270394
    AgonistAgonist6.310964567 10841540
    AHPN
    AgonistAgonist6.31315557
    MM 11253
    AntagonistAntagonist6.310723137

    8 Novoseek inferred chemical compound relationships for RARG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 89.4 176 19876792 (4), 11829754 (4), 12189556 (3), 2157210 (2) (see all 99)
    retinoid 84.5 13 7738355 (1), 12787882 (1), 12921748 (1), 7557150 (1) (see all 11)
    cd 437 80.2 1 9888458 (1)
    ttnpb 67.9 1 12611464 (1)
    vitamin a 54.5 1 11956581 (1)
    n-(4-hydroxyphenyl)retinamide 47.5 1 9892176 (1)
    estrogen 0 1 16995728 (1)
    serine 0 1 10748061 (1)



    RARG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RARG gene (5 alternative transcripts): 
    NM_000966.5  NM_001042728.2  NM_001243730.1  NM_001243731.1  NM_001243732.1  

    Unigene Cluster for RARG:

    Retinoic acid receptor, gamma
    Hs.1497  [show with all ESTs]
    Unigene Representative Sequence: NM_000966
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000425354(uc001scf.3 uc001scg.3 uc010soc.2) ENST00000338561
    ENST00000543726 ENST00000543762 ENST00000550265(uc010sod.2) ENST00000548317
    ENST00000551580 ENST00000548284 ENST00000546717 ENST00000551158 ENST00000550362
    ENST00000550721 ENST00000550350 ENST00000551501 ENST00000546377 ENST00000549859
    ENST00000552901 ENST00000394426(uc001scd.3 uc010sob.2 uc001sce.3)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat RARG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RARG (see all 59):
    hsa-miR-596 hsa-miR-4254 hsa-miR-330-5p hsa-miR-765 hsa-miR-30d hsa-miR-507 hsa-miR-764 hsa-miR-3667-5p
    SwitchGear 3'UTR luciferase reporter plasmidRARG 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat RARG
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RARG
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat RARG

    Additional mRNA sequence: 

    AB307689.1 AK290588.1 AK297023.1 AK297110.1 AK297277.1 AK297801.1 AK301057.1 AK316259.1 
    BC019098.2 BC064524.1 BC072462.1 BC093727.1 BC093729.1 BC098421.1 HQ229990.1 HQ692828.1 
    HQ692829.1 L12060.1 M24857.1 M32074.1 M38258.1 M57707.1 

    8 DOTS entries:

    DT.413711  DT.91764859  DT.87015126  DT.121175992  DT.91764858  DT.92029194  DT.100757735  DT.121175981 

    Selected AceView cDNA sequences (see all 159):

    BP374326 BQ884251 BQ182502 BM800054 BQ446816 BF915144 BU188921 BM807155 
    CA311258 BF914894 AA033924 AU141891 AU279504 AA496438 BX097697 BU618030 
    CB215421 BM542650 BE746846 BI060044 BU931848 BM977792 BI856804 BE886152 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RARG (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^
    SP1:                          -           -     -     -                                   -     -                                   -                           
    SP2:                          -           -     -     -                                   -     -                                   -                           
    SP3:                          -           -     -     -     -     -     -     -     -     -     -                                   -                           
    SP4:                                                                                                                                -                           
    SP5:                          -           -     -     -     -     -     -     -     -     -     -     -     -                       -                           

    ExUns: 11 ^ 12 ^ 13a · 13b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RARG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RARG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCTTGGGC
    RARG Expression
    About this image


    RARG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 7 entries
             Odontoblasts Dentin
             Dentin
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Osteochondro Mesenchymal Cells Vertebrae
             Vertebrae
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelial Cells
             Dental Placode Cells Dental Placode
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Diencephalic Neural Crest Cells Prechordal Mesenchyme
             Head Mesenchyme
    RARG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RARG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1497
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RARG: 
              Nuclear Receptors & Coregulators in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RARG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RARG gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rarg1 , 5 retinoic acid receptor, gamma1, 5 89.9(n)1
    98.89(a)1
      15 (57.40 cM)5
    194111  NM_011244.41  NP_035374.31 
     1022349385 
    lizard
    (Anolis carolinensis)
    Reptilia RARG6
    retinoic acid receptor, gamma
    79(a)
    1 ↔ 1
    2(70050662-70209183)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004853871 retinoic acid receptor gamma-like 73.19(n)
    84.89(a)
      100485387  XM_002936633.2  XP_002936679.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rargb1 retinoic acid receptor, gamma b 79.16(n)
    88.63(a)
      100034753  NM_001083310.1  NP_001076779.1 


    ENSEMBL Gene Tree for RARG (if available)
    TreeFam Gene Tree for RARG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RARG gene
    VDR2  PPARD2  NR1I22  PPARA2  THRB2  RARA2  NR1H42  NR1D22  
    RARB2  RORA2  RORB2  RORC2  NR1D12  NR1I32  PPARG2  NR1H22  
    THRA2  NR1H32  
    Selected SIMAP similar genes for RARG using alignment to 5 protein entries:     RARG_HUMAN (see all proteins) (see all similar genes):
    NR1B3    NR1B2    RARB    BCOR-RARA    NR1B1    PML-RAR
    PRKAR1A/RARA fusion    RARA    DKFZp761C0417    ESR1    NR1A1    ESRRA
    NR1D2    DKFZp686D1580    THRA    NR1A2    THRB    NR1F1

    RARG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RARG (see all 435)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360614
    A breast cancer sample4--see VAR_0360612 G S mis40--------
    rs111704761,2
    C,A--50648631(+) ATATAT/CACACA 5 -- int13Minor allele frequency- C:0.17WA NA CSA 6
    rs2012025841,2
    --50648670(+) CACAC-/ACAT  
            
    ACTTG
    5 -- int10--------
    rs2020292791,2
    --50648671(+) ACACA-/CATACT
            
    TGGAA
    5 -- int10--------
    rs2003039611,2
    --50648672(+) CACAC-/ATACTTG 5 -- int10--------
    rs1875780151,2
    --53437867(+) GCTCAC/TGCCTG 5 -- ds50010--------
    rs1901910231,2
    --53437977(+) TAAAAA/TAAATT 5 -- ds50010--------
    rs1501265371,2
    --53438154(+) AAACCC/TGGTCA 5 -- ds50010--------
    rs785913561,2
    C,F--53438251(+) GAAAGC/TTGCAA 5 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1384315671,2
    --53438255(+) GCTGCA/GAAGTC 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for RARG (53604353 - 53626764 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RARG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469404CNV Loss19166990
    nsv517066CNV Loss19592680
    nsv470295CNV Gain18288195
    nsv832417CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180190    OMIM disorders: --

    Selected diseases for RARG (see all 34):    
    About MalaCards
    hepatopulmonary syndrome    teratocarcinoma    rubella    bronchopulmonary dysplasia
    acute promyelocytic leukemia    keratoderma    xeroderma pigmentosum    myotonic dystrophy
    germ cell tumors    retinoblastoma    ulcerative colitis    crohn's disease
    acute myeloid leukemia    neuroblastoma    breast and colorectal cancer    tonsillitis
    pancreatitis    liver disease    myeloid leukemia    pancreatic cancer


    RARG for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for RARG gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 67.3 2 9892176 (1), 7731708 (1)
    teratocarcinoma 49.9 1 8108126 (1)
    pancreatic carcinoma 40.4 1 9753500 (1)
    premalignant 14.4 1 7723796 (1)
    carcinoma squamous cell 11.2 3 8649863 (1), 11340568 (1), 9058591 (1)
    ovarian carcinoma 9.28 2 11606393 (1), 11929843 (1)
    retinoblastoma 7.33 1 15383624 (1)
    cancer 4.59 3 12787882 (1), 11358845 (1), 11378441 (1)
    breast cancer 0 2 9139890 (1), 8603404 (1)
    adenocarcinoma 0 2 12680208 (1), 11231454 (1)

    Genetic Association Database (GAD): RARG
    Human Genome Epidemiology (HuGE) Navigator: RARG (12 documents)

    Export disorders for RARG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RARG gene, integrated from 10 sources (see all 191):
    (articles sorted by number of sources associating them with RARG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the retinoic acid receptor gamma gene. (PubMed id 1849262)1, 2, 3, 9 Lehmann J.M.... Pfahl M. (Nucleic Acids Res. 1991)
    2. Murine isoforms of retinoic acid receptor gamma with specific patterns of expression. (PubMed id 2157210)1, 2, 9 Kastner P.... Chambon P. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    3. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. (PubMed id 19902255)1, 4 Ovsyannikova I.G....Poland G.A. (Hum. Genet. 2010)
    6. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    7. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    8. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
    9. Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (PubMed id 15635645)1, 4 Feng J....Sommer S.S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5916 HGNC: 9866 AceView: RARG Ensembl:ENSG00000172819 euGenes: HUgn5916
    ECgene: RARG H-InvDB: RARG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RARG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RARG Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Retinoic_acid_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RARG gene:
    Search GeneIP for patents involving RARG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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