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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RARB Gene

protein-coding GIFtS: 70
GCID: GC03P025194

retinoic acid receptor, beta

Explore 113 diseases affiliated with
RARB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Retinoic Acid Receptor, Beta¹ ²		Hepatitis B Virus Activated Protein²
HAP¹ ² ³ ⁵		Retinoic Acid Receptor Beta²
NR1B2¹ ² ³		Retinoic Acid Receptor Beta 2²
RRB2¹ ²		Retinoic Acid Receptor Beta 4²
Nuclear Receptor Subfamily 1 Group B Member 2² ³		Retinoic Acid Receptor Beta 5²
RAR-Beta¹		Retinoic Acid Receptor Beta Variant 1²
RAR-Epsilon¹		Retinoic Acid Receptor Beta Variant 2²
HBV-Activated Protein² ³		Retinoic Acid Receptor, Beta Polypeptide²

External Ids:	HGNC: 9865¹	Entrez Gene: 5915²	Ensembl: ENSG00000077092⁷	OMIM: 180220⁵	UniProtKB: P10826³

Export aliases for RARB gene to outside databases

Previous GC identifers: GC03P025167 GC03P025066 GC03P025191 GC03P025192 GC03P025444

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RARB:

This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear

transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic

acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell

growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene

expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus

integration site. The gene expresses at least two transcript variants; one additional transcript has been described,

but its full length nature has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RARB_HUMAN, P10826

Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in

response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological

processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3'

sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression

due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth

plate function

summary for RARB:

Retinoic acid receptors (RARs) are nuclear hormone receptors of the NRB1 class, which function as

heterodimers with retinoid X receptors (RXRs). There are three distinct RAR subtypes; RARalpha, RARbeta and

RARgamma. RARalpha is present in most tissue types, whereas RARbeta and RARgamma expression is more

selective. RXR-RAR heterodimers act as ligand-dependent transcriptional regulators by binding to the

specific retinoic acid response element (RARE) found in the promoter regions of target genes. In the absence

of an RAR agonist, RXR-RAR recruits co-repressor proteins such as NCoR and associated factors such as

histone deacetylase to maintain a condensed chromatin structure. RAR agonist binding stimulates co-repressor

release and co-activator complexes, such as histone acetyltransferase, are recruited to activate

transcription. RARs transduce retinoid signals in vivo, which mediates proper embryogenesis, differentiation

and growth arrest. Specifically, RXRalpha-RARgamma heterodimers are necessary for growth arrest and viseral

and primitive endodermal differentiation, whereas RXRalpha-RARalpha is required for cAMP-dependent parietal

endodermal differentiation. In vitro it has been difficult to elucidate the roles of individual subtypes as

functional RAR knockouts generate artificial redundancies that are thought not to exist under normal

conditions.

Gene Wiki entry for RARB (Retinoic acid receptor beta)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RARB gene promoter:
C/EBPbeta CBF-B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RARB promoter sequence

Search SABiosciences Chromatin IP Primers for RARB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RARB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2 Ensembl cytogenetic band: 3p24.2 HGNC cytogenetic band: 3p24

RARB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RARB gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P025194: view genomic region (about GC identifiers)

Start:	25,215,823 bp from pter	End:	25,639,423 bp from pter
Size:	423,601 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RARB_HUMAN, P10826 (See protein sequence)

Recommended Name: Retinoic acid receptor beta

Size: 455 amino acids; 50489 Da

Subunit: Homodimer (By similarity). Heterodimer; with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer

(By similarity). Interacts weakly with NCOR2

Subcellular location: Isoform Beta-1: Nucleus

Subcellular location: Isoform Beta-2: Nucleus

Subcellular location: Isoform Beta-4: Cytoplasm

Sequence caution: Sequence=CAA27637.1; Type=Erroneous gene model prediction;

4 PDB 3D structures from and Proteopedia for RARB:

1HRA (3D)

1XAP (3D)

4DM6 (3D)

4DM8 (3D)

Secondary accessions: P12891 Q00989 Q15298 Q9UN48

Alternative splicing: 4 isoforms: P10826-1 P10826-2 P10826-4 P10826-3

Explore the universe of human proteins at neXtProt for RARB: NX_P10826

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10826

RARB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000956.2 NP_057236.1

ENSEMBL proteins:

ENSP00000373282 ENSP00000398840 ENSP00000332296 ENSP00000391391 ENSP00000385865

Reactome Protein details: P10826
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): RARB OriGene Custom Protein Services for RARB
	GenScript Custom Purified and Recombinant Proteins Services for RARB
	Novus Biologicals RARB Proteins Novus Biologicals RARB Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18845237
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IEA	--

RARB for ontologies About GeneDecksing

RARB Antibody Products:

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	Novus Biologicals RARB Antibodies
	Abcam antibodies for RARB
	Browse Antibodies at Uscn
	ThermoFisher Antibody for RARB

Assay Products for RARB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RARB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RARB for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR008946 Nucl_hormone_rcpt_ligand-bd

IPR001723 Str_hrmn_rcpt

IPR003078 Retinoic_acid_rcpt

IPR013088 Znf_NHR/GATA

IPR000536 Nucl_hrmn_rcpt_lig-bd_core

Graphical View of Domain Structure for InterPro Entry P10826

ProtoNet protein and cluster: P10826

2 Blocks protein families:

IPB001723 Steroid hormone receptor signature

IPB003078 Retinoic acid receptor (1B nuclear receptor) signature

UniProtKB/Swiss-Prot: RARB_HUMAN, P10826

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding

domain

Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RARB_HUMAN, P10826

Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in

response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological

processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3'

sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression

due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth

plate function

Genatlas biochemistry entry for RARB:

retinoic acid receptor binding and activated by both all-trans (T-RA) and its 9-cis isomer (9-cis-RA) retinoic

acids,beta subunit ,steroid/thyroid hormone receptor superfamily

miRNA Products:		miRTarBase miRNAs that target RARB: hsa-mir-16-2 (MIRT004488)

		OriGene 3'-UTR Clone (see all 2): RARB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RARB
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate RARB (see all 55):
		hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-29a hsa-miR-30d hsa-miR-449a hsa-miR-548m

		SwitchGear 3'UTR luciferase reporter plasmid: RARB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RARB (see all 4) OriGene shRNA RFP: RARB OriGene siRNA: RARB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RARB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RARB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RARB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RARB (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RARB (NM_016152)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RARB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RARB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RARB
		Search LifeMap BioReagents cell lines for RARB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RARB

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	2153268
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0003707	steroid hormone receptor activity	IEA	--
GO:0003708	retinoic acid receptor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

RARB for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for RARB: Rarb^tm1Vgi Rarb^tm2.1Ipc Rarb^tm1Ipc Rarb^tm1Mma
     15/20 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Rarb) (see all 20):

behavior/neurological	cardiovascular system	craniofacial	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	immune system
limbs/digits/tail	mortality/aging	muscle	nervous system	normal

RARB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription_Sin3 and NuRD in transcription regulation

Transcription_Sin3 and NuRD in transcription regulation

1.00

Transcription Sin3 and NuRD in transcription regulation

0.96

Nuclear Receptor transcription pathway

Nuclear Receptor transcription pathway

1.00

Nuclear Receptors

0.68

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

all-trans-Retinoic Acid Mediated Apoptosis

all-trans-Retinoic Acid Mediated Apoptosis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RARB

Transcription Sin3 and NuRD in transcription regulation

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RARB

	Nuclear Receptor Activation by Vitamin-A
	Molecular Mechanisms of Cancer
	all-trans-Retinoic Acid Signaling in Brain
	all-trans-Retinoic Acid Mediated Apoptosis

1 GeneGo (Thomson Reuters) Pathway for RARB

Transcription Sin3 and NuRD in transcription regulation

5 BioSystems Pathways for RARB

	Vitamin A and carotenoid metabolism
	Nuclear Receptors
	Integrated Pancreatic Cancer Pathway
	Nuclear receptors in lipid metabolism and toxicity
	Integrated Pancreatic Cancer Pathway

3 Reactome Pathways for RARB

	Generic Transcription Pathway
	Nuclear Receptor transcription pathway
	Gene Expression

3 Kegg Pathways (Kegg details for RARB):

	Pathways in cancer
	Small cell lung cancer
	Non-small cell lung cancer

RARB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RARB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/58 Interacting proteins for RARB (P10826^{2, 3} ENSP00000332296⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 58)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD2	Q15796²^,³	MINT-61612 I2D: score=3
PRKD2	Q9BZL6²^,³	MINT-61761 I2D: score=2
RXRB	P28702³, ENSP00000363812⁴	I2D: score=2 STRING: ENSP00000363812
ZNF423	Q2M1K9³, ENSP00000262383⁴	I2D: score=2 STRING: ENSP00000262383
GATA3	P23771³, ENSP00000368632⁴	I2D: score=1 STRING: ENSP00000368632

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001657	ureteric bud development	IEA	--
GO:0003417	growth plate cartilage development	IEA	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0007165	signal transduction	TAS	2833708

RARB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RARB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for RARB available from Tocris Bioscience About this table

Compound	Action	CAS #
AM 580	Retinoic acid analog; RARalpha agonist	[102121-60-8]
LE 135	Selective RARbeta antagonist	[155877-83-1]
CD 2665	Selective RARbeta/gamma antagonist	[170355-78-9]
Fenretinide	Synthetic retinoid. Potent anticancer agent	[65646-68-6]
Adapalene	RARbeta and RARgamma agonist	[106685-40-9]

1 HMDB Compound for RARB About this table

Compound	Synonyms	CAS #	PubMed Ids
Retinoic acid	Retinoate (see all 21)	302-79-4	--

7 DrugBank Compounds for RARB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alitretinoin	9-cis-Retinoic acid (see all 4)	5300-03-8	target	agonist	16253547 19678713 16128742 16531051 16297713 16316409
Adapalene	Adapaleno [INN-Spanish] (see all 2)	106685-40-9	target	agonist	9990413 11752352 9557255 9204085
Tamibarotene	Am 80 (see all 2)	94497-51-5	target	agonist	17611697 17925887 15563242 15843826
Tazarotene	--	118292-40-3	target	agonist	18034539 12942109 15102095 9035701
Acitretin	--	55079-83-9	target	agonist	7755585 19144697 11586072
Etretinate	--	54350-48-0	target	agonist	9298126 8301142
TTNPB	(E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl)-1 -propenyl] benzoic acid (see all 8)	71441-28-6	target	--	15546741 10592235

10/71 Novoseek chemical compound relationships for RARB gene (see all 71) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	95.9	1504	8707417 (10), 8034721 (7), 10866321 (7), 7998926 (7) (see all 99)
retinoid	94.2	166	10369704 (4), 12767074 (4), 9425148 (3), 8954130 (3) (see all 98)
ch 55	86.6	4	7556191 (1), 2154975 (1), 10747926 (1), 11769677 (1)
ttnpb	82.8	3	2175182 (1), 9006080 (1)
cd 2019	82.7	5	8216300 (2), 19800972 (1), 10374844 (1), 11726401 (1)
am 580	80.3	12	18271925 (3), 8216300 (2), 12504905 (1), 11726401 (1) (see all 6)
ttnn	79.2	1	7812950 (1)
cd 437	78.7	5	8216300 (2), 10953043 (1), 10374844 (1), 9516142 (1)
am80	76.6	1	2154975 (1)
sr 11217	74.5	1	7812950 (1)

Search CenterWatch for drugs/clinical trials and news about RARB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RARB gene (2 alternative transcripts):

NM_000965.3 NM_016152.3

Unigene Clusters for RARB:

Retinoic acid receptor, beta

Hs.654490 [show with all ESTs], Hs.733004

Unigene Representative Sequences: NM_000965, S82362

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000383772 ENST00000437042(uc003cdi.2) ENST00000330688(uc003cdh.3)

ENST00000489694 ENST00000480001 ENST00000462272 ENST00000479097 ENST00000458646(uc011awl.2)

ENST00000404969

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RARB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RARB
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate RARB (see all 55):
		hsa-miR-520f hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-29a hsa-miR-30d hsa-miR-449a hsa-miR-548m

		SwitchGear 3'UTR luciferase reporter plasmid: RARB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RARB (see all 4) OriGene shRNA RFP: RARB OriGene siRNA: RARB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RARB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RARB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RARB (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RARB (NM_016152)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RARB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RARB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RARB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RARB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RARB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RARB

Additional cDNA sequence: S82362.1

6 DOTS entries:

DT.100748508 DT.414721 DT.120925299 DT.120925216 DT.100679239 DT.91797951

24/91 AceView cDNA sequences (see all 91):

CD014022 CA390471 BX390267 AA917936 BM727498 BU740742 AA419238 BM722961

CD014020 AF157483 AA147673 N66800 CD014021 BC030234 BM719146 CD679225

BF062606 AL547687 CR536558 CR621137 CA447720 CA392074 CB049411 BP872510

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RARB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTCTCCTG

About this image

RARB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Interstitial Stroma

Interstitial Stroma Cells

Selective marker (cell-identifying gene)

Kidney

Bone, Cartilage

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 8 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Embryoid bodies (Generation of adipoc...)

Posterior foregut-like cells (A scalable, suspensi...)

HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)

Adipose

See RARB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RARB

SOURCE GeneReport for Unigene clusters: Hs.654490 Hs.733004

SABiosciences Expression via Pathway-Focused PCR Arrays including RARB (see all 6):

Lung Cancer in human mouse rat

Breast Cancer in human mouse rat

Polycomb & Trithorax Target Genes in human mouse rat

Prostate Cancer in human mouse rat

Nuclear Receptors & Coregulators in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RARB gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RARB¹	retinoic acid receptor, beta	86.45(n) 96.21(a)		396266 NM_205326.1 NP_990657.1
lizard (Anolis carolinensis)	Reptilia	RARB⁶	--	94(a)	1 ↔ 1	GL343380.1(790817-902499)
African clawed frog (Xenopus laevis)	Amphibia	LOC397983²	retinoic acid receptor gamma isoform 2.1	77.79(n)		S82173.1
zebrafish (Danio rerio)	Actinopterygii	rarga¹	retinoic acid receptor gamma a	68.29(n) 75.93(a)		30606 NM_131339.1 NP_571414.1

ENSEMBL Gene Tree for RARB (if available)
TreeFam Gene Tree for RARB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RARB gene

VDR² NR4A3² NR4A1² NR1I2² RARG² NR1I3² THRB² RARA²

NR4A2² NR1H4² NR1H2² THRA² NR1H3²

18/50 SIMAP similar genes for RARB using alignment to 6 protein entries: RARB_HUMAN (see all proteins) (see all similar genes):

NR1B2 RARG BCOR-RARA RARA PML-RAR NR1B3

NR1B1 HNF4G NR6A1 PRKAR1A/RARA fusion RORA DKFZp761C0417

NR5A1 HNF4alpha NR2C2 ESR1 NR3C2 DKFZp779O0162

RARB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75953970^1,2	C,	--	25414014(+)	`TATGCG/ATTTAA`	2	--	us2k¹		2	CSA WA	120
rs9827454^1,2	C,F,H,	--	25414311(+)	`cgtggG/Atagta`	2	--	us2k¹		8	NS EA NA	992
rs79358455^1,2	F,	--	25414494(+)	`ATTTTC/TTGTGT`	2	--	us2k¹		1	WA	118
rs78541681^1,2	F,	--	25416051(+)	`CCTCCC/TGCCCC`	2	--	int¹		1	WA	118
rs113483053^1,2	C,	--	25416630(+)	`AAAAAT/AATATT`	2	--	int¹		1	NA	2
rs75800125^1,2	F,	--	25416856(+)	`CATTGG/CAGCAT`	2	--	int¹		1	WA	118
rs4376002^1,2	H	--	25417001(+)	`TTAAAT/ATGCCC`	2	--	int¹		4	NS EA	420
rs7639075^1,2	C,H,	--	25417010(+)	`CCTCTC/GTGAAA`	2	--	int¹		4	NS EA	420
rs4423731^1,2	H	--	25417053(+)	`GCCAGG/AAAATC`	2	--	int¹		4	NS EA	408
rs34720160^1,2	C,	--	25417171(+)	`GAAGGC/TGCCTT`	2	--	int¹		1	NA	2

HapMap Linkage Disequilibrium report for RARB (25215823 - 25465823 bp, first 250kb of RARB)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RARB: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RARB

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RARB for disorders           About GeneDecksing

OMIM gene information: 180220    OMIM disorders: --

20/113 diseases for RARB (see all 113):    About MalaCards

hepatitis b von hippel-lindau disease hepatocellular carcinoma hepatitis

variant creutzfeldt-jakob disease progesterone-receptor negative breast cancer carcinoma thyroiditis

familial adenomatous polyposis retinol binding protein lichen sclerosus neural tube defect

choroid plexus papilloma non-small cell lung carcinoma familial partial lipodystrophy congenital diaphragmatic hernia

testicular germ cell tumor leukoplakia chromophobe renal cell carcinoma soft tissue sarcoma

1 disease from the University of Copenhagen DISEASES database for RARB:

Lung cancer

10/88 Novoseek disease relationships for RARB gene (see all 88) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
teratocarcinoma	71	5	1323569 (1), 9419418 (1), 8353043 (1), 9457077 (1) (see all 5)
carcinoma embryonal	70.4	5	9140065 (1), 2162058 (1), 1379266 (1), 7731708 (1) (see all 5)
premalignant	67	26	11848477 (5), 7723796 (3), 15010078 (2), 15173091 (1) (see all 13)
leukemia promyelocytic acute	62.1	4	8801177 (1), 15189119 (1), 19317219 (1)
tumors	56.8	206	8180126 (3), 12469153 (3), 14715861 (3), 17998817 (3) (see all 99)
cancer lung	56.6	73	9426695 (4), 1717924 (4), 7923214 (3), 16841329 (2) (see all 33)
carcinoma squamous cell	54.7	40	11173543 (4), 9426070 (3), 12839965 (2), 10416619 (2) (see all 24)
hnscc	54.7	28	15959780 (5), 8012985 (3), 19885608 (2), 11687961 (2) (see all 8)
squamous cell lung cancer	53	1	8381540 (1)
cancer	52.9	76	10629053 (5), 12516107 (3), 8657191 (3), 9255592 (2) (see all 49)

Genetic Association Database (GAD): RARB
Human Genome Epidemiology (HuGE) Navigator: RARB (20 documents)
Tumor Gene Database (TGDB): RARB

Export disorders for RARB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RARB gene, integrated from 9 sources (see all 723):
(articles sorted by number of sources associating them with RARB)

Utopia: connect your pdf to the dynamic
world of online information

DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage. (PubMed id 16128742)^{1, 7, 9} Mizuiri H....Yasui W. (2005)
Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. (PubMed id 12554770)^{1, 2, 9} Hauksdottir H....Privalsky M.L. (2003)
Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness. (PubMed id 1663808)^{1, 2, 9} Shen S.... Kruijer W. (1991)
Elevated retinoic acid receptor beta(4) protein in human breast tumor cells with nuclear and cytoplasmic localization. (PubMed id 10411930)^{1, 2, 9} Sommer K.M.... Swisshelm K. (1999)
Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines. (PubMed id 8275470)^{1, 2, 9} Houle B.... Bradley W.E. (1994)
Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (PubMed id 15635645)^{1, 4} Feng J....Sommer S.S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The solution structure of the human retinoic acid receptor-beta DNA- binding domain. (PubMed id 8383553)^{1, 2} Knegtel R.M.A.... Kaptein R. (1993)
Homo- and heteronuclear NMR studies of the human retinoic acid receptor beta DNA-binding domain: sequential assignments and identification of secondary structure elements. (PubMed id 1321662)^{1, 2} Kathira M.... Kaptein R. (1992)
Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma. (PubMed id 2170809)^{1, 2} Dejean A. and de The H. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5915	HGNC: 9865	AceView: RARB	Ensembl:ENSG00000077092	euGenes: HUgn5915
ECgene: RARB	Kegg: 5915	H-InvDB: RARB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RARB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RARB	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RARB gene
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Patent Information for RARB gene:
Search GeneIP for patents involving RARB

GeneCards and IP:
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retinoic acid receptor, beta

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Lymphoblastic Leukemia Acute Childhood
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RARB Gene

retinoic acid receptor, beta

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