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RARB Gene

protein-coding GIFtS: 71

GC03P025194

retinoic acid receptor, beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HAP ^¹, ², ³, ⁵
NR1B2 ^¹, ², ³
RAR-beta ^³
RAR-epsilon ^², ³
RRB2 ^¹, ²

Descriptions
HBV-activated protein ^², ³
Nuclear receptor subfamily 1 group B member 2 ^³
hepatitis B virus activated protein ^²
retinoic acid receptor beta 2 ^²
retinoic acid receptor beta 4 ^²
retinoic acid receptor beta 5 ^²
retinoic acid receptor, beta ^²
retinoic acid receptor, beta polypeptide ^²

External Ids
HGNC: 9865¹
Entrez Gene: 5915²
UniProtKB: P10826³
Ensembl: ENSG00000077092⁷

Search outside databases for aliases for RARB gene

Previous GC identifers: GC03P025167 GC03P025066 GC03P025191 GC03P025192 GC03P025444

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RARB:

This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor

superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to

subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which

mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is

thought that this protein limits growth of many cell types by regulating gene expression. The gene

was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration

site. The gene expresses at least two transcript variants; one additional transcript has been

described, but its full length nature has not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: RARB_HUMAN, P10826

Function: This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate

development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell

function by directly regulating gene expression

Gene Wiki entry for RARB (Retinoic_acid_receptor_beta)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RARB gene

Entrez Gene cytogenetic band: 3p24 Ensembl cytogenetic band: 3p24.2 HGNC cytogenetic band: 3p24

RARB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P025194: (about GC identifiers)

Start:	25,190,893 bp from pter
End:	25,614,424 bp from pter
Size:	423,532 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RARB_HUMAN, P10826 (See protein sequence)

Recommended Name: Retinoic acid receptor beta

Size: 455 amino acids; 50489 Da

Subcellular location: Isoform Beta-1: Nucleus

Subcellular location: Isoform Beta-2: Nucleus

Subcellular location: Isoform Beta-4: Cytoplasm

PDB structure from and Proteopedia :

1HRA (3D)

1XAP (3D)

Secondary accessions: P12891 Q00989 Q15298 Q9UN48

Alternative splicing: 4 isoforms: P10826-1 P10826-2 P10826-4 P10826-3

REFSEQ proteins (2 alternative transcripts):

NP_000956.2 NP_057236.1

ENSEMBL proteins:

ENSP00000332296 ENSP00000373282 ENSP00000385865

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Retinoic Acid Receptor beta 2, Retinoic Acid Receptor beta)
	Human Recombinant Proteins from Abnova (RARB)

OriGene Purified Recombinant Human Protein: RARB

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for RARB:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RARB
	R&D Systems Antibodies for RARB (RAR beta/NR1B2)
	Antibodies from Abcam (Retinoic Acid Receptor beta 2, Retinoic Acid Receptor beta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RARB)
	Novus Biologicals Antibodies for RARB

Assays for RARB:

	Invitrogen Assays for RARB
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10826

ProtoNet protein and cluster: P10826

2 Blocks protein families:

IPB001723 Steroid hormone receptor signature

IPB003078 Retinoic acid receptor (1B nuclear receptor) signature

UniProtKB/Swiss-Prot: RARB_HUMAN, P10826

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a

C-terminal steroid-binding domain

Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RARB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RARB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000965

Applied Biosystems Silencer® siRNAs for RARB

Sigma-Aldrich siRNA and siRNA Panels for RARB

Sigma-Aldrich shRNA Panels and shRNA for RARB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RARB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000965
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000965
untagged cDNA clones in CMV expression vector (see all 2): NM_000965

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000965

UniProtKB/Swiss-Prot: RARB_HUMAN, P10826

Function: This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate

development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell

function by directly regulating gene expression

Genatlas biochemistry entry for RARB:

retinoic acid receptor binding and activated by both all-trans (T-RA) and its 9-cis isomer

(9-cis-RA) retinoic acids,beta subunit ,steroid/thyroid hormone receptor superfamily

15/21 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Rarb) (see all 21 ):

	behavior/neurological	craniofacial	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	immune system
lethality-prenatal/perinatal	limbs/digits/tail	muscle	nervous system	normal

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0003707	steroid hormone receptor activity	IEA	--
GO:0003708	retinoic acid receptor activity	TAS	2833708
GO:0008270	zinc ion binding	IEA	--
GO:0016563	transcription activator activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for RARB (Your Favorite Gene powered by Ingenuity)

Aryl Hydrocarbon Receptor Signaling
Small Cell Lung Cancer Signaling
Non-Small Cell Lung Cancer Signaling
RAR Activation
Wnt/&beta

GeneDecks RARB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RARB

5/47 Interacting proteins for RARB (P10826² ENSP00000373282³) via UniProtKB, MINT, and/or STRING (see all 47 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKD2	Q9BZL6²	MINT-61761
SMAD2	Q15796²	MINT-61612
NCOA1	ENSP00000320940³	STRING (score=.988)
NCOR2	ENSP00000348551³	STRING (score=.984)
HDAC7	ENSP00000309766³	STRING (score=.966)

About this table

5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001657	ureteric bud development	IEA	--
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007165	signal transduction	TAS	2833708

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RARB

Sigma-Aldrich Small Molecules for RARB:

Mixed Agonist/Antagonist Activator Antagonist Agonist Ligand

Compounds for RARB available from Tocris Bioscience

Compound	Action	CAS number
Fenretinide	Synthetic retinoid. Potent anti-cancer agent	[65646-68-6]
AM 580	Retinoic acid agonist	[102121-60-8]
AC 55649	Selective RARbeta2 agonist	[59662-49-6]
LE 135	Selective RARbeta antagonist	[155877-83-1]
Adapalene	RARbeta and RARgamma agonist	[106685-40-9]

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10/26 Novoseek chemical compound relationships for RARB gene (see all 26 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ch 55	86.91	4	7556191 (1), 2154975 (1), 10747926 (1), 11769677 (1)
ttnn	79.58	1	7812950 (1)
cd 2019	79.58	4	8216300 (2), 10374844 (1), 11726401 (1)
am80	76.40	1	2154975 (1)
sr 11217	74.87	1	7812950 (1)
sr 11237	73.16	6	12839938 (4), 11979430 (1)
ttab	70.52	1	7812950 (1)
n-4-methoxyphenylretinamide	61.54	1	8640761 (1)
o6-methylguanine	46.29	10	16203797 (1), 14633667 (1), 12730870 (1), 17182830 (1) (see all 6)
steroid	23.45	2	9368510 (1), 15234273 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RARB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RARB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000965

Sigma-Aldrich siRNA and siRNA Panels for RARB

Sigma-Aldrich shRNA Panels and shRNA for RARB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000965 NM_016152

REFSEQ mRNAs for RARB gene (2 alternative transcripts):

NM_000965.3 NM_016152.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000965 NM_016152

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000965
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000965
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000965

Additional cDNA sequence:

AB307688.1 AF157483.1 AK292032.1 AK299756.1 AY501390.1 BC030234.1 BC050415.2 BC060794.1

CR536558.1 CR621137.1 DQ083391.1 M62303.1 X07282.1 Y00291.1

6 DOTS entries:

DT.100748508 DT.414721 DT.120925299 DT.120925216 DT.100679239 DT.91797951

24/91 AceView cDNA sequences (see all 91 ):

CA392074 AA147673 BM727498 CD014021 N66800 CD014020 BU740742 AA419238

BX390267 CR621137 CD014022 BM722961 BF062606 CR536558 BC030234 AL547687

CA390471 BM719146 AA917936 AF157483 CD679225 CA447720 BP873248 BC069735

highest scoring ESTs for RARB:

Y00291 AA147673 AA419164 AA419238 AA424088 AA917936 AI004107 AI168535 AI369519 AI767065

Unigene Cluster for RARB:

Retinoic acid receptor, beta

Hs.654490 [show with all ESTs]

Unigene Representative Sequence: NM_000965

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000330688 ENST00000383772 ENST00000404969

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RARB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RARB

¹ / ² / ³

11 probe-sets matching RARB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32694_at²^{, 3}	U95-A	1	1.00	1.00	0.84	1.07	Y00291	1.00	1.00	1.00	1
1381_at²^{, 3}	U95-A	2	0.88	0.59	0.33	0.42	M62303	0.80	0.80	0.80	1
1632_at²	U95-A	1	0.38	1.00	0.23	0.99	--	--	--	--	--
208530_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016152	0.60	1.00	0.82	1
205080_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000965	0.60	1.00	0.82	1
208412_s_at²^{, 3}	U133-A	2	1.00	0.64	--	--	NM_015854	0.20	1.00	0.72	1
217020_at*²	U133-A	NULL	0.00	0.00	--	--	--	--	--	--	--
208530_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205080_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208412_s_at²	U133Plus2	2	1.00	0.64	--	--	--	--	--	--	--
217020_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGTCTCCTG

SOURCE GeneReport for Unigene cluster: Hs.654490
Expression variation in blood from EXPOLDB for RARB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RARB gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RARB¹	--	retinoic acid receptor, beta	95.24(n) 97.77(a)	477045 XM_857187.1 XP_862280.1
chimpanzee (Pan troglodytes)	RARB¹	--	retinoic acid receptor, beta	99.7(n) 100(a)	745516 XM_001164404.1 XP_001164404.1
mouse (Mus musculus)	Rarb^{1, 5}	14 (1.50 cM)⁵	retinoic acid receptor, beta^{1, 5}	91(n)¹ 98.44(a)¹	218772¹ NM_011243.1¹ NP_035373.1¹ AI746463⁵ AK078471⁵ (see all 13)
chicken (Gallus gallus)	RARB¹	--	retinoic acid receptor, beta	86.45(n) 96.21(a)	396266 NM_205326.1 NP_990657.1
zebrafish (Danio rerio)	rarga¹	--	retinoic acid receptor gamma a	68.29(n) 75.93(a)	30606 NM_131339.1 NP_571414.1

About this table Species with no ortholog for RARB

ENSEMBL Gene Tree for RARB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RARB gene

RARG² RARA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1023 NCBI SNPs in RARB are shown (see all 1023 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 415)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9827454^1,2	C,F,H	25443850(+)	`cgtggG/Atagta`	2	--	ng5¹		4	EU EA WA	418
	rs1286665^1,2	A,C,F,H,O	25550679(+)	`GTTAGC/TTGAAA`	2	--	int¹		11	EU EA WA NA	978
	rs1153600^1,2	A,C,F,H,O	25544569(+)	`GTCTGC/TGGAGT`	2	--	int¹		17	MN EA NA EU WA	1584
	rs957950^1,2	A,C,F,H,O	25471678(+)	`GAGCAA/GTTTGA`	2	--	int¹		7	NA EA EU WA	666
	rs1368266^1,2	A,C,F,H,O	25471849(-)	`atcaaT/Cggtga`	2	--	int¹		5	MN EU NA	446
	rs1153591^1,2	A,C,F,H,O	25532520(+)	`TCTTGG/ACATTT`	2	--	int¹		9	MN EU EA WA	1022
	rs1286667^1,2	A,C,F,H,O	25551316(+)	`GCTGCT/CAGTGC`	2	--	int¹		7	MN EA WA NA	586
	rs1992005^1,2	A,C,F,H,O	25551869(-)	`TTGCCC/TGATGT`	2	--	int¹		13	EA NA EU WA	1118
	rs1153594^1,2	A,C,F,H,O	25534932(+)	`GGAGAC/TGTCAT`	2	--	int¹		11	EA MN NA EU WA	998
	rs1286756^1,2	A,C,F,H,O	25542084(+)	`GTTTTA/GGATGA`	2	--	int¹		10	MN EU EA WA NA	920

About this table

HapMap Linkage Disequilibrium images for RARB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 180220

10/83 Novoseek disease relationships for RARB gene (see all 83 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma embryonal	71.24	5	9140065 (1), 2162058 (1), 1379266 (1), 7731708 (1) (see all 5)
teratocarcinoma	70.75	5	1323569 (1), 9419418 (1), 8353043 (1), 9457077 (1) (see all 5)
premalignant	68.14	26	11848477 (5), 7723796 (3), 15010078 (2), 15173091 (1) (see all 13)
leukemia promyelocytic acute	62.33	4	8801177 (1), 15189119 (1), 19317219 (1)
cancer lung	56.82	72	9426695 (4), 1717924 (4), 7923214 (3), 16841329 (2) (see all 32)
tumors	55.89	192	8180126 (3), 12469153 (3), 14715861 (3), 17998817 (3) (see all 93)
carcinoma squamous cell	55.33	40	11173543 (4), 9426070 (3), 12839965 (2), 10416619 (2) (see all 24)
hnscc	55.02	26	15959780 (5), 8012985 (3), 11687961 (2), 10416619 (2) (see all 7)
squamous cell lung cancer	54.65	1	8381540 (1)
cancer	53.49	73	10629053 (5), 12516107 (3), 8657191 (3), 9255592 (2) (see all 47)

About this table

Genetic Association Database: RARB
Human Genome Epidemiology Navigator: RARB (8 documents)
Tumor Gene Database: RARB

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/566 PubMed articles for RARB gene (see all 566 ):

Elevated retinoic acid receptor beta(4) protein in human breast tumor cells with nuclear and cytoplasmic localization. (PubMed id 10411930)^{1, 3, 4} Sommer K.M.... Swisshelm K. (1999)
Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines. (PubMed id 8275470)^{1, 3, 4} Houle B.... Bradley W.E. (1994)
Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (PubMed id 15635645)^{3, 6} Feng J....Sommer S.S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The solution structure of the human retinoic acid receptor-beta DNA- binding domain. (PubMed id 8383553)^{3, 4} Knegtel R.M.A.... Kaptein R. (1993)
Homo- and heteronuclear NMR studies of the human retinoic acid receptor beta DNA-binding domain: sequential assignments and identification of secondary structure elements. (PubMed id 1321662)^{3, 4} Kathira M.... Kaptein R. (1992)
Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness. (PubMed id 1663808)^{3, 4} Shen S.... Kruijer W. (1991)
Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma. (PubMed id 2170809)^{3, 4} Dejean A. and de The H. (1990)
Identification of a second human retinoic acid receptor. (PubMed id 2833708)^{3, 4} Brand N.... Dejean A. (1988)
A new retinoic acid receptor identified from a hepatocellular carcinoma. (PubMed id 2836738)^{3, 4} Benbrook D.... Pfahl M. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5915	HGNC: 9865	AceView: RARB	Ensembl:ENSG00000077092	euGenes: HUgn5915
ECgene: RARB	H-InvDB: RARB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RARB	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RARB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RARB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RARB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RARB		Antibodies for RARB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RARB		Small molecules for RARB
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RARB)
	Antibodies (RARB)
	Chimera RNAi (RARB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Retinoic Acid Receptor beta 2, Retinoic Acid Receptor beta)
	Antibodies (Retinoic Acid Receptor beta 2, Retinoic Acid Receptor beta)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for RARB

	Drugs for RARB
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RARB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
RARB Gene at Home site.
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RARB Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for RARB

Summaries
for RARB

Genomic Location
for RARB

Proteins
for RARB

Protein Domains/
Families
for RARB

Gene Function
for RARB

Pathways & Interactions
for RARB

Drugs & Compounds
for RARB

Transcripts
for RARB

Expression
for RARB

Orthologs
for RARB

Paralogs
for RARB

SNPs/Variants
for RARB

Disorders & Mutations
for RARB

Medical News
for RARB

Publications
for RARB

Search for RARB

Genome Databases showing RARB

Other Databases showing RARB

Specialized Databases showing RARB

Licensable Technologies
for RARB

Services
for RARB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RARB Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor RARB

Summariesfor RARB

Genomic Locationfor RARB

Proteinsfor RARB

Protein Domains/Familiesfor RARB

Gene Functionfor RARB

Pathways & Interactionsfor RARB

Drugs & Compoundsfor RARB

Transcriptsfor RARB

Expression for RARB

Orthologsfor RARB

Paralogsfor RARB

SNPs/Variantsfor RARB

Disorders & Mutationsfor RARB

Medical Newsfor RARB

Publicationsfor RARB

Search for RARB

Genome Databases showing RARB

Other Databases showing RARB

Specialized Databases showing RARB

Licensable Technologiesfor RARB

Servicesfor RARB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RARB

Summaries
for RARB

Genomic Location
for RARB

Proteins
for RARB

Protein Domains/
Families
for RARB

Gene Function
for RARB

Pathways & Interactions
for RARB

Drugs & Compounds
for RARB

Transcripts
for RARB

Expression
for RARB

Orthologs
for RARB

Paralogs
for RARB

SNPs/Variants
for RARB

Disorders & Mutations
for RARB

Medical News
for RARB

Publications
for RARB

Licensable Technologies
for RARB

Services
for RARB