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RARA Gene

protein-coding GIFtS: 74

GC17P035718

retinoic acid receptor, alpha
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
NR1B1 ^¹, ², ³
OTTHUMP00000164454 ^²
OTTHUMP00000164456 ^²
RAR ^¹, ²
RAR-alpha ^³

Descriptions
Nuclear receptor subfamily 1 group B member 1 ^³
Retinoic acid receptor, alpha polypeptide ^²
nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form ^²
retinoic acid receptor, alpha ^²

External Ids
HGNC: 9864¹
Entrez Gene: 5914²
UniProtKB: P10276³
Ensembl: ENSG00000131759⁷

Search outside databases for aliases for RARA gene

Previous GC identifers: GC17P037961 GC17P040640 GC17P038374 GC17P038838 GC17P038860

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RARA:

Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR)

and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of

ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM

600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to

the complex, it induces a conformational change allowing the recruitment of coactivators, histone

acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that

always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic

leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the

RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by

OMIM]

UniProtKB/Swiss-Prot: RARA_HUMAN, P10276

Function: This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate

development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell

function by directly regulating gene expression

Gene Wiki entry for RARA (Retinoic_acid_receptor_alpha)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RARA gene

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q12

RARA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P035718: (about GC identifiers)

Start:	35,718,972 bp from pter
End:	35,767,420 bp from pter
Size:	48,449 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010755.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RARA_HUMAN, P10276 (See protein sequence)

Recommended Name: Retinoic acid receptor alpha

Size: 462 amino acids; 50771 Da

Subunit: Interacts with CDK7 (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading

to a strong increase of transcription of target genes. Interacts with NOCA7 in a ligand-inducible

manner

Subcellular location: Nucleus

PDB structure from and Proteopedia :

1DKF (3D)

1DSZ (3D)

Secondary accessions: P78456 Q13440 Q13441 Q96S41 Q9NQS0

Alternative splicing: 2 isoforms: P10276-1 P10276-2

Post-translational modifications:

Phosphorylated. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is

crucial for transcriptional activity (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_000955.1 NP_001019980.1 NP_001138773.1 NP_001138774.1

ENSEMBL proteins:

ENSP00000377643 ENSP00000377648 ENSP00000254066 ENSP00000316769 ENSP00000377649

Human Recombinant Proteins

	Invitrogen human recombinant proteins for RARA
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PML+RARA Fusion, Retinoic Acid Receptor alpha)
	Human Recombinant Proteins from Abnova (RARA)

OriGene Purified Recombinant Human Protein: RARA

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0009986	cell surface	IC	2825025

About this table

Antibodies for RARA:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of RARA
	Sigma-Aldrich Antibodies for RARA
	R&D Systems Antibodies for RARA (RAR alpha/NR1B1)
	Cell Signaling Technology (CST) Antibodies for RARA (RAR)
	Antibodies from Abcam (PML+RARA Fusion, Retinoic Acid Receptor alpha), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RARA)
	Novus Biologicals Antibodies for RARA

Assays for RARA:

	Invitrogen Assays for RARA
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10276

ProtoNet protein and cluster: P10276

2 Blocks protein families:

IPB001723 Steroid hormone receptor signature

IPB003078 Retinoic acid receptor (1B nuclear receptor) signature

UniProtKB/Swiss-Prot: RARA_HUMAN, P10276

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a

C-terminal steroid-binding domain

Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RARA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RARA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): BC008727

Applied Biosystems Silencer® siRNAs for RARA

Sigma-Aldrich siRNA and siRNA Panels for RARA

Sigma-Aldrich shRNA Panels and shRNA for RARA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000964
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000964
untagged cDNA clones in CMV expression vector (see all 6): BC008727

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000964

UniProtKB/Swiss-Prot: RARA_HUMAN, P10276

Function: This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate

development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell

function by directly regulating gene expression

Genatlas biochemistry entry for RARA:

retinoic acid receptor binding and activated by both all-trans (T-RA) and its 9-cis isomer

(9-cis-RA) retinoic acids,alpha subunit,steroid/thyroid hormone receptor superfamily

15/23 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Rara) (see all 23 ):

	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	hematopoietic system	immune system	lethality-prenatal/perinatal
life span-post-weaning/aging	limbs/digits/tail	liver/biliary system	muscle	nervous system

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001972	retinoic acid binding	IDA	2825025
GO:0003700	transcription factor activity	IEA	--
GO:0003707	steroid hormone receptor activity	IEA	--
GO:0003708	retinoic acid receptor activity	IEA	--
GO:0003713	transcription coactivator activity	IDA	2825025

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for RARA (Your Favorite Gene powered by Ingenuity) (see all 8 )

FXR/RXR Activation
Hepatic Cholestasis
RAR Activation
LPS/IL-1 Mediated Inhibition of RXR Function
Acute Myeloid Leukemia Signaling

GeneDecks RARA for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RARA

5/78 Interacting proteins for RARA (ENSP00000316769³ P10276^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 78 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCOA1	Q15788²	STRING (score=.968) MINT-2834489 MINT-5209864
MED1	Q15648²	STRING (score=.96) MINT-5209905
NRIP1	P48552²	STRING (score=.997) MINT-5209920
RXRA	P19793²	STRING (score=.999) MINT-24895
RXRG	P48443²	STRING (score=.958) MINT-67080

About this table

5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007165	signal transduction	IDA	2825025
GO:0030520	estrogen receptor signaling pathway	IDA	15831516
GO:0032355	response to estradiol stimulus	IDA	15831516

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RARA

Sigma-Aldrich Small Molecules for RARA:

Mixed Agonist/Antagonist Activator Antagonist Agonist Ligand

Compounds for RARA available from Tocris Bioscience

Compound	Action	CAS number
Liarozole hydrochloride	Blocks retinoic acid metabolism	[145858-50-0]
Fenretinide	Synthetic retinoid. Potent anti-cancer agent	[65646-68-6]
AM 580	Retinoic acid agonist	[102121-60-8]
AM 80	RARalpha agonist; anticancer	[94497-51-5]

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10/45 Novoseek chemical compound relationships for RARA gene (see all 45 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alpha-retinoic acid	86.50	11	2171781 (2), 1715692 (1), 8396481 (1), 8207983 (1) (see all 8)
am80	85.79	21	19292987 (3), 9720716 (2), 11034091 (1), 11945126 (1) (see all 13)
ch 55	85.73	8	10704935 (2), 9720716 (1), 2154975 (1), 1652063 (1) (see all 5)
cd 2019	85.67	8	8216300 (3), 11302942 (1), 9639510 (1), 10374844 (1) (see all 5)
sr 11237	80.47	6	7852380 (1), 10865976 (1), 8626453 (1)
ttnn	79.42	1	11945128 (1)
agn 193109	78.02	6	15035668 (2), 12879006 (1), 10419474 (1), 11278809 (1) (see all 5)
sr 11217	74.69	1	8025272 (1)
ttab	74.12	5	9516142 (1), 11945128 (1), 8744592 (1), 8025272 (1)
arotinoid	72.17	1	8600988 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RARA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RARA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): BC008727

Sigma-Aldrich siRNA and siRNA Panels for RARA

Sigma-Aldrich shRNA Panels and shRNA for RARA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000964 NM_001024809

REFSEQ mRNAs for RARA gene (4 alternative transcripts):

NM_000964.2 NM_001024809.2 NM_001145301.1 NM_001145302.1

NM_000964 NM_001024809

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000964
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000964
                                 untagged cDNA clones in CMV expression vector (see all 6): BC008727

Additional cDNA sequence:

AJ417079.1 AK098172.1 AK130192.1 AK292205.1 AK303868.1 AK312564.1 AL834159.1 BC008727.2

BC071733.1 CR457438.1 CR600029.1 CR619304.1 EF535849.1 FJ487576.1 S50916.1 U41742.1

U41743.1 X06538.1 X06614.1

18 DOTS entries:

DT.91783369 DT.92050958 DT.99941648 DT.95370577 DT.100765128 DT.100830912 DT.101971683 DT.410549

DT.95370607 DT.100045856 DT.120902317 DT.95240375 DT.95370753 DT.100722877 DT.100771550 DT.120902307

DT.91814374 DT.95370560

24/179 AceView cDNA sequences (see all 179 ):

CR600029 BI522425 BQ044936 CD673268 AW298630 BC071733 BQ706025 BC008727

CR619304 AK098172 BE312686 BQ425845 BM675691 BE313602 BM679122 BU543219

T95682 BF433022 BQ958419 BM709400 BQ937216 T83788 BM722189 X06614

highest scoring ESTs for RARA:

X06614 AA595224 AA670427 AA811759 AA812217 AI005074 AI089567 AI203431 AI218536 AI276019

Unigene Cluster for RARA:

Retinoic acid receptor, alpha

Hs.654583 [show with all ESTs]

Unigene Representative Sequence: NM_001024809

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RARA (see all 8 )

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15
SP1:					-						-		-		-		-		-		-		-
SP2:			-		-						-		-		-		-		-		-		-
SP3:															-		-		-		-		-
SP4:																							-
SP5:																	-		-		-		-

About this scheme

ECgene alternative splicing isoforms for RARA

5 Ensembl transcripts including schematic representations:

ENST00000394081 ENST00000394086 ENST00000254066 ENST00000319149 ENST00000394089

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RARA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RARA

¹ / ² / ³

10 probe-sets matching RARA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1337_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X06614	1.00	1.00	1.00	1
216300_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE383139	0.40	1.00	0.76	1
203750_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000964	0.60	1.00	0.82	1
203749_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI806984	0.80	1.00	0.91	1
211605_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U41742	0.40	1.00	0.76	1
216300_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1565358_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203750_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203749_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211605_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGACCCCGCA

SOURCE GeneReport for Unigene cluster: Hs.654583
Expression variation in blood from EXPOLDB for RARA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RARA gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RARA¹	--	retinoic acid receptor, alpha	94.66(n) 99.35(a)	480526 NM_001012645.1 NP_001012663.1
rat (Rattus norvegicus)	Rara¹	--	retinoic acid receptor, alpha	89.56(n) 96.87(a)	24705 NM_031528.1 NP_113716.1
mouse (Mus musculus)	Rara^{1, 5}	11 (57.80 cM)⁵	retinoic acid receptor, alpha^{1, 5}	91.56(n)¹ 98.27(a)¹	19401¹ NM_009024.2¹ NP_033050.2¹ AB221572⁵ AI614117⁵ (see all 24)
zebrafish (Danio rerio)	rara2a²	--	retinoic acid receptor, alpha 2a	80.27(n)	30680 S74155.1
fruit fly (Drosophila melanogaster)	Eip75B³	3 75B1--6	molting cycle (sensu Insecta) ligand-dependent more	30(a)	--

About this table Species with no ortholog for RARA

ENSEMBL Gene Tree for RARA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RARA gene

RARB² RARG²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/104 NCBI SNPs in RARA are shown (see all 104 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2229773^1,2	C,F,H	35766006(+)	`GTGACC/TGCCCA`	2	--	ut3¹ ese³		5	MN EU EA WA	464
	rs7222102^1,2	F,H	35718876(+)	`CAGTCG/TGGGCT`	1	--	ng5¹		4	EU EA WA	418
	rs2229772^1,2	F,H	35766095(+)	`CTGCCC/GCCACC`	2	--	ut3¹ ese³		2	MN EU	182
	rs2715552^1,2	H	35749881(-)	`TATGGG/AAAAAG`	2	--	ng5¹ int¹ trp³		4	EU EA WA	416
	rs2920395^1,2	H	35750794(+)	`TTCTAG/AAAGAA`	2	--	int¹ ng5¹		4	EU EA WA	418
	rs9303285^1,2	A,C,F,H	35754440(+)	`CCACAT/CCCATT`	2	--	int¹		4	EU EA WA	414
	rs7224658^1,2	A,C,F,H	35738572(+)	`atacaA/Gcattt`	1	--	int¹		5	EU WA NA	346
	rs9303286^1,2	A,C,F,H	35754454(+)	`GGGTGG/CGGTAG`	2	--	int¹		4	EU EA WA	400
	rs12946680^1,2	A,C,F,H	35734183(+)	`TTCTAC/GGTGGA`	1	--	int¹		8	EA NA EU WA	592
	rs482284^1,2	A,C,F,H	35757767(+)	`GGGCAG/AGAGCT`	2	--	int¹		9	MN EU EA WA	1020

About this table

HapMap Linkage Disequilibrium images for RARA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 180240 disorders: 612376

UniProtKB/Swiss-Prot: RARA_HUMAN, P10276

Chromosomal aberrations involving RARA may be a cause of acute promyelocytic leukemia

(APL) [MIM:612376]. Translocation t(11;17)(q32;q21) with ZBTB16/PLZF; translocation

t(15;17)(q21;q21) with PML; translocation t(5;17)(q32;q11) with NPM

10/89 Novoseek disease relationships for RARA gene (see all 89 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia promyelocytic acute	95.96	349	1668609 (2), 7987829 (2), 1652369 (2), 1317727 (2) (see all 99)
promyelocytic leukemia	87.99	148	8387545 (3), 8238249 (2), 11454693 (2), 12794076 (2) (see all 83)
leukemogenesis	76.99	19	7529139 (1), 11066449 (1), 2173802 (1), 8580793 (1) (see all 14)
carcinoma embryonal	69.31	12	1661245 (1), 1320576 (1), 2162058 (1), 8604312 (1) (see all 10)
leukemia	69.13	133	10441338 (4), 1911341 (2), 8819070 (2), 12935958 (2) (see all 73)
myeloid leukemia	60.50	14	15339853 (2), 1970118 (1), 9952315 (1), 11607822 (1) (see all 12)
teratocarcinoma	58.08	5	2152965 (2), 8218362 (1), 8353043 (1), 17875646 (1)
minimal residual disease	57.46	3	1375840 (1), 7723389 (1), 7672716 (1)
breast cancer	50.06	121	9205071 (6), 9387294 (5), 15870697 (4), 11034091 (3) (see all 53)
cancer	46.08	59	12188922 (3), 10389997 (3), 9368510 (3), 16179254 (2) (see all 41)

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Genatlas disease: RARA

acute promyelocytic leukemia or myeloid leukemia (APL),common breakpoints in translocation t

(15;17) clustered in RARA second intron (see PML),in translocation t(11;17) (see ZNF145),in

translocation t(5;17),and others

Genetic Association Database: RARA
Human Genome Epidemiology Navigator: RARA (11 documents)
Tumor Gene Database: RARA

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1026 PubMed articles for RARA gene (see all 1026 ):

Identification of a receptor for the morphogen retinoic acid. (PubMed id 2825036)^{2, 3, 4} Giguere V.... Evans R.M. (1987)
The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. (PubMed id 8562957)^{1, 3, 4} Redner R.L.... Corey S.J. (1996)
[Possible association due to linkage disequilibrium of TGFA, RARA and BCL3 with nonsyndromic cleft lip with or without cleft palate in the Chilean population] (PubMed id 16311697)^{1, 3, 6} Suazo J....Blanco R. (2005)
Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (PubMed id 15635645)^{1, 3, 6} Feng J....Sommer S.S. (2005)
Retinoic acid receptor alpha gene variants, multivitamin use, and liver intake as risk factors for oral clefts: a population-based case-control study in Denmark, 1991-1994. (PubMed id 12835288)^{1, 3, 6} Mitchell L.E....Christensen K. (2003)
PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors. (PubMed id 8302850)^{1, 3, 4} Chen Z.... Chomienne C. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Cytogenetics, FISH and RT-PCR analysis of acute promyelocytic leukemia: structure of the fusion point in a case lacking classic t(15;17) translocation. (PubMed id 12691149)^{3, 4} Fujita K....Omine M. (2003)
ERAP140, a conserved tissue-specific nuclear receptor coactivator. (PubMed id 11971969)^{3, 4} Shao W.... Brown M. (2002)
A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. (PubMed id 10567404)^{3, 4} Lee S.-K.... Lee J.W. (1999)

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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5914	HGNC: 9864	AceView: RARA	Ensembl:ENSG00000131759	euGenes: HUgn5914
ECgene: RARA	H-InvDB: RARA

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RARA	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Retinoic_acid_receptor

Licensable Technologies for RARA
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for RARA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RARA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RARA		Antibodies for RARA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RARA		Small molecules for RARA
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RARA)
	Antibodies (RARA)
	Chimera RNAi (RARA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for RARA (RAR)

	Recombinant Proteins (PML+RARA Fusion, Retinoic Acid Receptor alpha)
	Antibodies (PML+RARA Fusion, Retinoic Acid Receptor alpha)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for RARA

	Drugs for RARA
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RARA

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RARA Gene

protein-coding GIFtS: 74

Aliases &
Descriptions
for RARA

Summaries
for RARA

Genomic Location
for RARA

Proteins
for RARA

Protein Domains/
Families
for RARA

Gene Function
for RARA

Pathways & Interactions
for RARA

Drugs & Compounds
for RARA

Transcripts
for RARA

Expression
for RARA

Orthologs
for RARA

Paralogs
for RARA

SNPs/Variants
for RARA

Disorders & Mutations
for RARA

Medical News
for RARA

Publications
for RARA

Search for RARA

Genome Databases showing RARA

Other Databases showing RARA

Specialized Databases showing RARA

Licensable Technologies
for RARA

Services
for RARA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RARA Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor RARA

Summariesfor RARA

Genomic Locationfor RARA

Proteinsfor RARA

Protein Domains/Familiesfor RARA

Gene Functionfor RARA

Pathways & Interactionsfor RARA

Drugs & Compoundsfor RARA

Transcriptsfor RARA

Expression for RARA

Orthologsfor RARA

Paralogsfor RARA

SNPs/Variantsfor RARA

Disorders & Mutationsfor RARA

Medical Newsfor RARA

Publicationsfor RARA

Search for RARA

Genome Databases showing RARA

Other Databases showing RARA

Specialized Databases showing RARA

Licensable Technologiesfor RARA

Servicesfor RARA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RARA

Summaries
for RARA

Genomic Location
for RARA

Proteins
for RARA

Protein Domains/
Families
for RARA

Gene Function
for RARA

Pathways & Interactions
for RARA

Drugs & Compounds
for RARA

Transcripts
for RARA

Expression
for RARA

Orthologs
for RARA

Paralogs
for RARA

SNPs/Variants
for RARA

Disorders & Mutations
for RARA

Medical News
for RARA

Publications
for RARA

Licensable Technologies
for RARA

Services
for RARA