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Aliases for RAPGEFL1 Gene

Aliases for RAPGEFL1 Gene

  • Rap Guanine Nucleotide Exchange Factor Like 1 2 3 5
  • Link Guanine Nucleotide Exchange Factor II 2 3 4
  • Rap Guanine Nucleotide Exchange Factor (GEF)-Like 1 2 3
  • Link GEFII 3 4
  • RAP Guanine-Nucleotide-Exchange Factor (GEF)-Like 1 2
  • Rap Guanine Nucleotide Exchange Factor-Like 1 3
  • Link-GEFII 3

External Ids for RAPGEFL1 Gene

Previous GeneCards Identifiers for RAPGEFL1 Gene

  • GC17P038710
  • GC17P035588
  • GC17P038333
  • GC17P034127

Summaries for RAPGEFL1 Gene

GeneCards Summary for RAPGEFL1 Gene

RAPGEFL1 (Rap Guanine Nucleotide Exchange Factor Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and signal transducer activity, downstream of receptor. An important paralog of this gene is RAPGEF5.

UniProtKB/Swiss-Prot for RAPGEFL1 Gene

  • Probable guanine nucleotide exchange factor (GEF).

Additional gene information for RAPGEFL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAPGEFL1 Gene

Genomics for RAPGEFL1 Gene

GeneHancer (GH) Regulatory Elements for RAPGEFL1 Gene

Promoters and enhancers for RAPGEFL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I040175 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.1 -68 2.5 HDGF RB1 RFX5 ZEB1 ZNF335 EGR1 ZNF143 EGR2 SP3 REST RAPGEFL1 CASC3 MSL1 CDC6 ENSG00000266208 KRTAP4-6 PIR47710 GC17P040124
GH17I040178 Enhancer 0.6 ENCODE dbSUPER 550.8 +1.4 1414 0.2 CTCF ZNF143 REST RAPGEFL1 MIR6867 GC17P040124
GH17I040217 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 19.6 +42.1 42149 2.9 HDGF FOXA2 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 WIPF2 MED1 CDK12 SMARCE1 RAPGEFL1 PGAP3 MSL1 STARD3 IGFBP4 ENSG00000266208
GH17I040337 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.9 +168.1 168141 15.1 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 FOS RARA MSL1 RAPGEFL1 ENSG00000266208 RARA-AS1 WIPF2 CASC3 ENSG00000278918
GH17I040061 Promoter/Enhancer 2.9 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -107.7 -107715 14.8 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 THRA GC17P040067 MED1 MED24 SMARCE1 MSL1 GSDMA CDK12 RAPGEFL1 PSMD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAPGEFL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAPGEFL1 gene promoter:

Genomic Locations for RAPGEFL1 Gene

Genomic Locations for RAPGEFL1 Gene
18,647 bases
Plus strand

Genomic View for RAPGEFL1 Gene

Genes around RAPGEFL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAPGEFL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAPGEFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAPGEFL1 Gene

Proteins for RAPGEFL1 Gene

  • Protein details for RAPGEFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rap guanine nucleotide exchange factor-like 1
    Protein Accession:

    Protein attributes for RAPGEFL1 Gene

    662 amino acids
    Molecular mass:
    73265 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAG36274.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAPGEFL1 Gene

    Alternative splice isoforms for RAPGEFL1 Gene


neXtProt entry for RAPGEFL1 Gene

Post-translational modifications for RAPGEFL1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RAPGEFL1 Gene

Domains & Families for RAPGEFL1 Gene

Gene Families for RAPGEFL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAPGEFL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAPGEFL1: view

No data available for UniProtKB/Swiss-Prot for RAPGEFL1 Gene

Function for RAPGEFL1 Gene

Molecular function for RAPGEFL1 Gene

UniProtKB/Swiss-Prot Function:
Probable guanine nucleotide exchange factor (GEF).

Phenotypes From GWAS Catalog for RAPGEFL1 Gene

Gene Ontology (GO) - Molecular Function for RAPGEFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with RAPGEFL1: view
genes like me logo Genes that share phenotypes with RAPGEFL1: view

Animal Models for RAPGEFL1 Gene

MGI Knock Outs for RAPGEFL1:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAPGEFL1 Gene

Localization for RAPGEFL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAPGEFL1 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Microtubules (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAPGEFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane TAS 9582122
genes like me logo Genes that share ontologies with RAPGEFL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RAPGEFL1 Gene

Pathways & Interactions for RAPGEFL1 Gene

SuperPathways for RAPGEFL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAPGEFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 9582122
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007399 nervous system development TAS 9789079
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with RAPGEFL1: view

No data available for Pathways by source and SIGNOR curated interactions for RAPGEFL1 Gene

Drugs & Compounds for RAPGEFL1 Gene

(3) Drugs for RAPGEFL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RAPGEFL1: view

Transcripts for RAPGEFL1 Gene

Unigene Clusters for RAPGEFL1 Gene

Rap guanine nucleotide exchange factor (GEF)-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAPGEFL1 Gene

No ASD Table

Relevant External Links for RAPGEFL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAPGEFL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAPGEFL1 Gene

mRNA differential expression in normal tissues according to GTEx for RAPGEFL1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.4), Skin - Not Sun Exposed (Suprapubic) (x7.0), and Esophagus - Mucosa (x6.3).

Protein differential expression in normal tissues from HIPED for RAPGEFL1 Gene

This gene is overexpressed in Esophagus (39.2) and Heart (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAPGEFL1 Gene

Protein tissue co-expression partners for RAPGEFL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAPGEFL1 Gene:


SOURCE GeneReport for Unigene cluster for RAPGEFL1 Gene:


Evidence on tissue expression from TISSUES for RAPGEFL1 Gene

  • Nervous system(3.3)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with RAPGEFL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAPGEFL1 Gene

Orthologs for RAPGEFL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAPGEFL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAPGEFL1 33 34
  • 99.56 (n)
(Bos Taurus)
Mammalia RAPGEFL1 33 34
  • 92.91 (n)
(Canis familiaris)
Mammalia RAPGEFL1 33 34
  • 92.25 (n)
(Mus musculus)
Mammalia Rapgefl1 33 16 34
  • 89.04 (n)
(Rattus norvegicus)
Mammalia Rapgefl1 33
  • 88.43 (n)
(Monodelphis domestica)
Mammalia RAPGEFL1 34
  • 65 (a)
(Anolis carolinensis)
Reptilia RAPGEFL1 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rapgefl1 33
  • 68.57 (n)
(Danio rerio)
Actinopterygii LOC100149497 33
  • 63.33 (n)
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Epac 34
  • 16 (a)
(Caenorhabditis elegans)
Secernentea epac-1 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 17 (a)
Species where no ortholog for RAPGEFL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAPGEFL1 Gene

Gene Tree for RAPGEFL1 (if available)
Gene Tree for RAPGEFL1 (if available)

Paralogs for RAPGEFL1 Gene

(5) SIMAP similar genes for RAPGEFL1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAPGEFL1: view

Variants for RAPGEFL1 Gene

Sequence variations from dbSNP and Humsavar for RAPGEFL1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs864622033 uncertain-significance, Malignant tumor of prostate 40,188,883(+) A/G coding_sequence_variant, missense_variant
rs1000002518 -- 40,175,807(+) C/T upstream_transcript_variant
rs1000202385 -- 40,195,833(+) G/C downstream_transcript_variant
rs1000212969 -- 40,179,256(+) AG/ genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000245370 -- 40,179,573(+) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAPGEFL1 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv525796 CNV gain 19592680
nsv833444 CNV loss 17160897

Variation tolerance for RAPGEFL1 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAPGEFL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAPGEFL1 Gene

Disorders for RAPGEFL1 Gene

Additional Disease Information for RAPGEFL1

No disorders were found for RAPGEFL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAPGEFL1 Gene

Publications for RAPGEFL1 Gene

  1. Screening aberrant methylation profile in esophageal squamous cell carcinoma for Kazakhs in Xinjiang area of China. (PMID: 25304811) Chen Y … Tian W (Molecular biology reports 2015) 3 58
  2. Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation. (PMID: 24312652) Takahashi T … Ushijima T (PloS one 2013) 3 58
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  5. Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1. (PMID: 20706999) Brieger A … Trojan J (Proteomics 2010) 3 58

Products for RAPGEFL1 Gene

Sources for RAPGEFL1 Gene

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