Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAPGEFL1 Gene

Aliases for RAPGEFL1 Gene

  • Rap Guanine Nucleotide Exchange Factor Like 1 2 3 5
  • Link Guanine Nucleotide Exchange Factor II 2 3 4
  • RAP Guanine-Nucleotide-Exchange Factor (GEF)-Like 1 2 3
  • Rap Guanine Nucleotide Exchange Factor (GEF)-Like 1 2 3
  • Link GEFII 3 4
  • Rap Guanine Nucleotide Exchange Factor-Like 1 3
  • Link-GEFII 3

External Ids for RAPGEFL1 Gene

Previous GeneCards Identifiers for RAPGEFL1 Gene

  • GC17P038710
  • GC17P035588
  • GC17P038333
  • GC17P034127

Summaries for RAPGEFL1 Gene

GeneCards Summary for RAPGEFL1 Gene

RAPGEFL1 (Rap Guanine Nucleotide Exchange Factor Like 1) is a Protein Coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and signal transducer activity, downstream of receptor. An important paralog of this gene is RAPGEF5.

UniProtKB/Swiss-Prot for RAPGEFL1 Gene

  • Probable guanine nucleotide exchange factor (GEF).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAPGEFL1 Gene

Genomics for RAPGEFL1 Gene

Regulatory Elements for RAPGEFL1 Gene

Enhancers for RAPGEFL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F040217 1.4 FANTOM5 ENCODE 19.6 +42.1 42111 2.8 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MED1 ENSG00000266469 IGFBP4 CDK12 RAPGEFL1 LOC105371776 PGAP3 ERBB2 RPL23AP75 ENSG00000266208
GH17F040337 1.7 FANTOM5 Ensembl ENCODE 11.9 +168.2 168214 15.0 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 FOS ZNF263 SP3 RARA MSL1 RAPGEFL1 ENSG00000266208 RARA-AS1 WIPF2 CASC3 ENSG00000278918
GH17F040432 1 Ensembl ENCODE 18.8 +256.5 256535 1.5 BCOR CTCF PKNOX1 ESRRA ZMYM3 ZIC2 RAD21 ZFHX2 GATA2 ZNF143 RAPGEFL1 CDC6 ENSG00000266208 RARA-AS1 GC17M040441 GC17M040417
GH17F040250 1.2 Ensembl ENCODE 15.5 +74.6 74623 1.8 PKNOX1 INSM2 KLF17 SIN3A FEZF1 ZNF121 ZNF366 RCOR1 ZNF391 ZNF362 RAPGEFL1 MSL1 WIPF2 CDC6 TOP2A ENSG00000266208 GC17M040243 RNY4P8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAPGEFL1 on UCSC Golden Path with GeneCards custom track

Promoters for RAPGEFL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001806998 790 1201 HDGF CBX3 ARNT KLF17 ZNF2 RAD21 ZEB1 GLIS2 EGR1 ZNF391

Genomic Location for RAPGEFL1 Gene

40,177,010 bp from pter
40,195,656 bp from pter
18,647 bases
Plus strand

Genomic View for RAPGEFL1 Gene

Genes around RAPGEFL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAPGEFL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAPGEFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAPGEFL1 Gene

Proteins for RAPGEFL1 Gene

  • Protein details for RAPGEFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rap guanine nucleotide exchange factor-like 1
    Protein Accession:

    Protein attributes for RAPGEFL1 Gene

    662 amino acids
    Molecular mass:
    73265 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAG36274.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAPGEFL1 Gene

    Alternative splice isoforms for RAPGEFL1 Gene


neXtProt entry for RAPGEFL1 Gene

Post-translational modifications for RAPGEFL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RAPGEFL1 Gene

Domains & Families for RAPGEFL1 Gene

Suggested Antigen Peptide Sequences for RAPGEFL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RAPGEFL1: view

No data available for Gene Families for RAPGEFL1 Gene

Function for RAPGEFL1 Gene

Molecular function for RAPGEFL1 Gene

UniProtKB/Swiss-Prot Function:
Probable guanine nucleotide exchange factor (GEF).

Gene Ontology (GO) - Molecular Function for RAPGEFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with RAPGEFL1: view
genes like me logo Genes that share phenotypes with RAPGEFL1: view

Animal Models for RAPGEFL1 Gene

MGI Knock Outs for RAPGEFL1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAPGEFL1 Gene

Localization for RAPGEFL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAPGEFL1 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAPGEFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane TAS 9582122
genes like me logo Genes that share ontologies with RAPGEFL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RAPGEFL1 Gene

Pathways & Interactions for RAPGEFL1 Gene

SuperPathways for RAPGEFL1 Gene

No Data Available

Interacting Proteins for RAPGEFL1 Gene

Selected Interacting proteins: Q9UHV5-RPGFL_HUMAN for RAPGEFL1 Gene via IID

Gene Ontology (GO) - Biological Process for RAPGEFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 9582122
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007399 nervous system development TAS 9789079
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RAPGEFL1: view

No data available for Pathways by source and SIGNOR curated interactions for RAPGEFL1 Gene

Drugs & Compounds for RAPGEFL1 Gene

(3) Drugs for RAPGEFL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RAPGEFL1: view

Transcripts for RAPGEFL1 Gene

Unigene Clusters for RAPGEFL1 Gene

Rap guanine nucleotide exchange factor (GEF)-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAPGEFL1 Gene

No ASD Table

Relevant External Links for RAPGEFL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAPGEFL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAPGEFL1 Gene

mRNA differential expression in normal tissues according to GTEx for RAPGEFL1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.4), Skin - Not Sun Exposed (Suprapubic) (x7.0), and Esophagus - Mucosa (x6.3).

Protein differential expression in normal tissues from HIPED for RAPGEFL1 Gene

This gene is overexpressed in Esophagus (39.2) and Heart (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAPGEFL1 Gene

Protein tissue co-expression partners for RAPGEFL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAPGEFL1 Gene:


SOURCE GeneReport for Unigene cluster for RAPGEFL1 Gene:

genes like me logo Genes that share expression patterns with RAPGEFL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RAPGEFL1 Gene

Orthologs for RAPGEFL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAPGEFL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAPGEFL1 34 35
  • 99.56 (n)
(Bos Taurus)
Mammalia RAPGEFL1 34 35
  • 92.91 (n)
(Canis familiaris)
Mammalia RAPGEFL1 34 35
  • 92.25 (n)
(Mus musculus)
Mammalia Rapgefl1 34 16 35
  • 89.04 (n)
(Rattus norvegicus)
Mammalia Rapgefl1 34
  • 88.43 (n)
(Monodelphis domestica)
Mammalia RAPGEFL1 35
  • 65 (a)
(Anolis carolinensis)
Reptilia RAPGEFL1 35
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rapgefl1 34
  • 68.57 (n)
(Danio rerio)
Actinopterygii LOC100149497 34
  • 63.33 (n)
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Epac 35
  • 16 (a)
(Caenorhabditis elegans)
Secernentea epac-1 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
Species where no ortholog for RAPGEFL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAPGEFL1 Gene

Gene Tree for RAPGEFL1 (if available)
Gene Tree for RAPGEFL1 (if available)

Paralogs for RAPGEFL1 Gene

(5) SIMAP similar genes for RAPGEFL1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAPGEFL1: view

Variants for RAPGEFL1 Gene

Sequence variations from dbSNP and Humsavar for RAPGEFL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs864622033 Uncertain significance 40,188,883(+) GAACC(A/G)GCCAC reference, missense
rs111394590 -- 40,182,018(+) GCAAA(C/G)GTTGC intron-variant
rs111460209 -- 40,177,712(+) GCGAG(A/G)CTCGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111667494 -- 40,186,531(+) CCACT(A/G)CAGTC intron-variant
rs111802485 -- 40,192,727(+) CTTCC(A/T)CCCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAPGEFL1 Gene

Variant ID Type Subtype PubMed ID
nsv833444 CNV loss 17160897
nsv525796 CNV gain 19592680
nsv1146669 OTHER inversion 26484159

Variation tolerance for RAPGEFL1 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAPGEFL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAPGEFL1 Gene

Disorders for RAPGEFL1 Gene

Relevant External Links for RAPGEFL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAPGEFL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAPGEFL1 Gene

Publications for RAPGEFL1 Gene

  1. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  3. Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1. (PMID: 20706999) Brieger A. … Trojan J. (Proteomics 2010) 3 64
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for RAPGEFL1 Gene

Sources for RAPGEFL1 Gene

Loading form....