RAPGEFL1 Gene
protein-coding GIFtS: 41
GCID: GC17P038333
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Rap guanine nucleotide exchange factor (GEF)-like 1(Previous name: RAP guanine-nucleotide-exchange factor (GEF)-like 1 )
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Aliases
for RAPGEFL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rap Guanine Nucleotide Exchange Factor (GEF)-Like 11 2 | | Link-GEFII1 2 | | RAP Guanine-Nucleotide-Exchange Factor (GEF)-Like 11 2 | | Link GEFII2 3 | | Link Guanine Nucleotide Exchange Factor II2 3 | | Rap Guanine Nucleotide Exchange Factor-Like 12 |
Export aliases for RAPGEFL1 gene to outside databasesPrevious GC identifers: GC17P038710 GC17P035588 GC17P034127 |
Summaries
for RAPGEFL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RPGFL_HUMAN, Q9UHV5Function: Probable guanine nucleotide exchange factor (GEF)
|
Genomic Views
for RAPGEFL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAPGEFL1 gene promoter:
Egr-3 TBP p53 Pax-5 ATF-2 Brachyury p300 Lmo2 CRE-BP1 SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAPGEFL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAPGEFL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.1 Ensembl cytogenetic band: 17q21.1 HGNC cytogenetic band: 17q21.2RAPGEFL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P038333: view genomic region
(about GC identifiers)
Start:
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38,333,263 bp from pter |
End:
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38,351,906 bp from pter |
Size:
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18,644 bases |
Orientation:
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plus strand |
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Proteins
for RAPGEFL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RPGFL_HUMAN, Q9UHV5 (See
protein sequence)Recommended Name: Rap guanine nucleotide exchange factor-like 1 Size: 662 amino acids; 73265 Da
Sequence caution: Sequence=BAG36274.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for RAPGEFL1:2DHZ (3D)
Alternative splicing: 3 isoforms: Q9UHV5-1 Q9UHV5-2 Q9UHV5-3 Explore the universe of human proteins at neXtProt for RAPGEFL1: NX_Q9UHV5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UHV5
RAPGEFL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057423.1
ENSEMBL proteins: ENSP00000394530 ENSP00000440226 ENSP00000438631 ENSP00000264644 ENSP00000440006 ENSP00000444646 ENSP00000441059 ENSP00000408322
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RAPGEFL1 for ontologies About GeneDecksing
RAPGEFL1 Antibody Products:
Assay Products for RAPGEFL1: |
Protein
Domains /
Families
for RAPGEFL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAPGEFL1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UHV5ProtoNet protein and cluster: Q9UHV5 1 Blocks protein family: IPB001895 Guanine-nucleotide dissociation stimulator CDC25
UniProtKB/Swiss-Prot: RPGFL_HUMAN, Q9UHV5Similarity: Contains 1 Ras-GEF domain |
Function
for RAPGEFL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RPGFL_HUMAN, Q9UHV5Function: Probable guanine nucleotide exchange factor (GEF)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEFL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEFL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: RAPGEFL1 (NM_016339) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAPGEFL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEFL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEFL1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005057 | receptor signaling protein activity |
-- | -- | | GO:0005085 | guanyl-nucleotide exchange factor activity |
IEA | -- |
RAPGEFL1 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Rapgefl1):
RAPGEFL1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAPGEFL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAPGEFL1
1 Interacting protein for RAPGEFL1 (Q9UHV53) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
RAPGEFL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RAPGEFL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAPGEFL1
3 HMDB Compounds for RAPGEFL1 About this table
Search CenterWatch for drugs/clinical trials and news about RAPGEFL1 / RPGFL
|
Transcripts
for RAPGEFL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAPGEFL1 gene: NM_016339.3 Unigene Cluster for RAPGEFL1: Rap guanine nucleotide exchange factor (GEF)-like 1 Hs.744194 [show with all ESTs]Unigene Representative Sequence: NM_01633912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000456989 ENST00000543876 ENST00000544503 ENST00000264644 ENST00000538884
ENST00000540388 ENST00000541245 ENST00000538981 ENST00000545893 ENST00000469209
ENST00000496032 ENST00000436615(uc010cwu.1 uc010wfd.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEFL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEFL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAPGEFL1 (NM_016339) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAPGEFL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEFL1 |
Additional cDNA sequence: AF117946.1 AK294642.1 AK304160.1 AK313492.1 BC029956.1 BC115374.1 BC115375.1 BC128521.1 U78518.1 8 DOTS entries: DT.310340 DT.120974143 DT.95361213 DT.86847942 DT.95348413 DT.75197439 DT.97792250 DT.92425229 24/126 AceView cDNA sequences (see all 126): BG057081 BM677918 AI700328 BC029956 T04994 AW139646 CD673750 CD627796 BU620959 BU858185 AA064784 CB850973 AI702874 CB241983 AL133709 BM757171 AI202634 BU620139 AA652368 BM019813 AA309020 AW014851 AF117946 NM_016339
GeneLoc Exon Structure
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Expression
for RAPGEFL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAPGEFL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTATTGTAC
About this image
See RAPGEFL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAPGEFL1
SOURCE GeneReport for Unigene cluster: Hs.744194
SABiosciences Custom PCR Arrays for RAPGEFL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAPGEFL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAPGEFL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAPGEFL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEFL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEFL1 |
Orthologs
for RAPGEFL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RAPGEFL1 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
RAPGEFL16 |
-- |
78(a) |
1 ↔ 1 |
6(69545041-69577405) |
zebrafish
(Danio rerio) |
Actinopterygii |
CU459159.16 |
-- |
44(a) |
1 ↔ 1 |
3(23621224-23698205) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Epac6 |
Epac |
16(a) |
1 → many |
2R(2647220-2686446) |
worm
(Caenorhabditis elegans) |
Secernentea |
epac-16 |
Rap guanine nucleotide exchange factor 1 |
13(a) |
1 → many |
III(10189127-10195308) |
ENSEMBL Gene Tree for RAPGEFL1 (if available)
TreeFam Gene Tree for RAPGEFL1 (if available) |
Paralogs
for RAPGEFL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAPGEFL1 gene
- RAPGEF22 RAPGEF62 RASGEF1A2 RAPGEF32 RASGEF1C2 RAPGEF42 RASGEF1B2 RAPGEF52
5 SIMAP similar genes for RAPGEFL1 using alignment to 6 protein entries: RPGFL_HUMAN (see all proteins):RAPGEF4 Nbla00496 DKFZp781H1715 RAPGEF5 RAPGEF3
RAPGEFL1 for paralogs About GeneDecksing
|
Genomic Variants
for RAPGEFL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAPGEFL1 (38333263 - 38351906 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAPGEFL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAPGEFL1 |
|
Disorders
/ Diseases
for RAPGEFL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RAPGEFL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAPGEFL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RAPGEFL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. (PubMed id 9582122)1 Ebinu J.O....Stone J.C. (1998)
- A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. (PubMed id 9789079)1 Kawasaki H.... Graybiel A.M. (1998)
|
External Searches for RAPGEFL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAPGEFL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAPGEFL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAPGEFL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RAPGEFL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RAPGEFL1 gene:
Search GeneIP for patents involving RAPGEFL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAPGEFL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RAPGEFL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAPGEFL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAPGEFL1 | | | OriGene Protein Over-expression Lysate for RAPGEFL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAPGEFL1 | | OriGene 3'-UTR Clone for RAPGEFL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEFL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEFL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAPGEFL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAPGEFL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAPGEFL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAPGEFL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEFL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAPGEFL1 |
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 | | | RAPGEFL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEFL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for RAPGEFL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEFL1 |
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