Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAPGEF6 Gene

protein-coding   GIFtS: 55
GCID: GC05M130759

Rap Guanine Nucleotide Exchange Factor (GEF) 6

(Previous name: PDZ domain containing guanine nucleotide exchange factor...)
(Previous symbol: PDZGEF2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rap Guanine Nucleotide Exchange Factor (GEF) 61 2     PDZ Domain-Containing Guanine Nucleotide Exchange Factor 22 3
PDZGEF21 2 3 5     RAGEF22 5
PDZ Domain Containing Guanine Nucleotide Exchange Factor (GEF) 21 2     KIA001LB2
PDZ-GEF22 3     PDZ Domain-Containing Guanine Nucleotide Exchange Factor I2
RA-GEF-22 3     Rap Guanine Nucleotide Exchange Factor 62

External Ids:    HGNC: 206551   Entrez Gene: 517352   Ensembl: ENSG000001589877   OMIM: 6104995   UniProtKB: Q8TEU73   

Export aliases for RAPGEF6 gene to outside databases

Previous GC identifers: GC05M130838 GC05M130789 GC05M125950


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RAPGEF6 Gene: 
RAPGEF6 (Rap guanine nucleotide exchange factor (GEF) 6) is a protein-coding gene. Diseases associated with RAPGEF6 include schizophrenia. GO annotations related to this gene include Ras GTPase binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RAPGEFL1.

UniProtKB/Swiss-Prot: RPGF6_HUMAN, Q8TEU7
Function: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP

Gene Wiki entry for RAPGEF6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAPGEF6 gene promoter:
         GR   Egr-3   C/EBPbeta   Evi-1   YY1   Egr-4   FOXL1   CREB   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAPGEF6 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAPGEF6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAPGEF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

RAPGEF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAPGEF6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M130759:  view genomic region     (about GC identifiers)

Start:
130,759,614 bp from pter      End:
130,970,929 bp from pter
Size:
211,316 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPGF6_HUMAN, Q8TEU7 (See protein sequence)
Recommended Name: Rap guanine nucleotide exchange factor 6  
Size: 1601 amino acids; 179423 Da
Subunit: Interacts with the second PDZ domain of human PTP1e
Subcellular location: Cytoplasm. Cell membrane. Note=Upon binding to M-Ras, it translocates to the plasma membrane
2 PDB 3D structures from and Proteopedia for RAPGEF6:
2D93 (3D)        3LNY (3D)    
Secondary accessions: A3KN82 A5PLL6 B7ZML2 E9PDV7 Q8NI21 Q8TEU6 Q96PC1
Alternative splicing: 6 isoforms:  Q8TEU7-1   Q8TEU7-2   Q8TEU7-3   Q8TEU7-4   Q8TEU7-5   Q8TEU7-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAPGEF6: NX_Q8TEU7

Explore proteomics data for RAPGEF6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TEU7

  • RAPGEF6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAPGEF6 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001157858.1  NP_001157859.1  NP_001157860.1  NP_001157861.1  NP_001157862.1  NP_057424.3  

    ENSEMBL proteins: 
     ENSP00000421684   ENSP00000426081   ENSP00000296859   ENSP00000426910   ENSP00000311419  
     ENSP00000425772   ENSP00000425389   ENSP00000424574   ENSP00000425891   ENSP00000427102  
     ENSP00000309298  

    Human Recombinant Protein Products for RAPGEF6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RAPGEF6
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for RAPGEF6 
    OriGene Custom Protein Services for RAPGEF6
    GenScript Custom Purified and Recombinant Proteins Services for RAPGEF6
    Novus Biologicals RAPGEF6 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAPGEF6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA11524421

    RAPGEF6 for ontologies           About GeneDecksing



    RAPGEF6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RAPGEF6
    GenScript Custom Superior Antibodies Services for RAPGEF6
    Novus Biologicals RAPGEF6 Antibodies
    Abcam antibodies for RAPGEF6
    Cloud-Clone Corp. Antibodies for RAPGEF6 
    Search ThermoFisher Antibodies for RAPGEF6
    LSBio Antibodies in human, mouse, rat for RAPGEF6 

    Assay Products for RAPGEF6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAPGEF6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAPGEF6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAPGEF6 
    Cloud-Clone Corp. CLIAs for RAPGEF6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR008937 Ras_GEF
     IPR018490 cNMP-bd-like
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000159 Ras-assoc

    Graphical View of Domain Structure for InterPro Entry Q8TEU7

    ProtoNet protein and cluster: Q8TEU7

    4 Blocks protein domains:
    IPB000159 RA domain
    IPB000595 Cyclic nucleotide-binding domain
    IPB001478 PDZ/DHR/GLGF domain
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: RPGF6_HUMAN, Q8TEU7
    Similarity: Contains 1 cyclic nucleotide-binding domain
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Ras-GEF domain


    RAPGEF6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPGF6_HUMAN, Q8TEU7
    Function: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity IDA11524421
    GO:0005515protein binding IPI14698303
    GO:0017016Ras GTPase binding IDA11524421
    GO:0030742GTP-dependent protein binding IDA11524421
         
    RAPGEF6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RAPGEF6:
     Decreased G3BP1 protein expres  Synthetic lethal with c-Myc af 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rapgef6):
     cellular  hematopoietic system  immune system  no phenotypic analysis 

    RAPGEF6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rapgef6tm1.1Tkat for RAPGEF6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAPGEF6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAPGEF6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAPGEF6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAPGEF6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAPGEF6
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RAPGEF6 (see all 31):
    hsa-miR-217 hsa-miR-495 hsa-miR-4328 hsa-miR-522 hsa-miR-202 hsa-miR-4263 hsa-miR-410 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidRAPGEF6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAPGEF6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAPGEF6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAPGEF6
    Sirion Biotech Customized adenovirus for overexpression of RAPGEF6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RAPGEF6 (see all 27)
    OriGene ORF clones in mouse, rat for RAPGEF6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): RAPGEF6 (NM_016340)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAPGEF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEF6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAPGEF6
    Search LifeMap BioReagents cell lines for RAPGEF6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAPGEF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for RAPGEF6 (Q8TEU72, 3 ENSP000002968594) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN13Q129232, 3, ENSP000003947944MINT-8311478 MINT-8311520 MINT-8311503 I2D: score=1 STRING: ENSP00000394794
    MRASO148073, ENSP000002891044I2D: score=2 STRING: ENSP00000289104
    RAP1AP628343, ENSP000003487864I2D: score=2 STRING: ENSP00000348786
    ABCA1O954773, ENSP000003638684I2D: score=1 STRING: ENSP00000363868
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----
    GO:0007265Ras protein signal transduction NAS11524421
    GO:0043087regulation of GTPase activity NAS11524421
    GO:0051056regulation of small GTPase mediated signal transduction IEA--

    RAPGEF6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAPGEF6 (RPGF6)

    4 HMDB Compounds for RAPGEF6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RAPGEF6 / RPGF6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAPGEF6 gene (6 alternative transcripts): 
    NM_001164386.1  NM_001164387.1  NM_001164388.1  NM_001164389.1  NM_001164390.1  NM_016340.5  

    Unigene Cluster for RAPGEF6:

    Rap guanine nucleotide exchange factor (GEF) 6
    Hs.483329  [show with all ESTs]
    Unigene Representative Sequence: NM_001164386
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509018(uc003kvm.2 uc010jdi.2 uc003kvn.2 uc003kvp.2)
    ENST00000512611 ENST00000507093 ENST00000296859 ENST00000512052(uc003kvq.3)
    ENST00000308008(uc011cxe.2 uc003kvr.3) ENST00000515170 ENST00000510071(uc010jdk.3)
    ENST00000504919 ENST00000514179 ENST00000513227 ENST00000504575 ENST00000504039
    ENST00000503398 ENST00000307984(uc003kvo.2 uc010jdj.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAPGEF6
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RAPGEF6 (see all 31):
    hsa-miR-217 hsa-miR-495 hsa-miR-4328 hsa-miR-522 hsa-miR-202 hsa-miR-4263 hsa-miR-410 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidRAPGEF6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAPGEF6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAPGEF6
    Clone
    Products:
         
    OriGene clones in human, mouse for RAPGEF6 (see all 27)
    OriGene ORF clones in mouse, rat for RAPGEF6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): RAPGEF6 (NM_016340)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAPGEF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEF6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RAPGEF6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAPGEF6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAPGEF6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEF6

    Additional mRNA sequence: 

    AF085846.1 AF394782.1 AF478468.1 AF478469.1 AF478567.1 AK056296.1 AK074318.1 AK302640.1 
    AL832899.1 BC133703.1 BC140820.1 BC142964.1 BC144627.1 BX649095.1 

    17 DOTS entries:

    DT.95338742  DT.442313  DT.215318  DT.101967566  DT.406025  DT.95269706  DT.91640537  DT.427424 
    DT.437867  DT.91699017  DT.102833188  DT.120807318  DT.120807339  DT.95185759  DT.95293174  DT.100007947 
    DT.92020518 

    24/244 AceView cDNA sequences (see all 244):

    AV711836 AI160015 AA436713 AA287000 CD107125 AA247766 AW297496 AL596926 
    CA389429 BX643625 CA950363 BE302207 BU675061 AA258023 AA741126 AW449299 
    BX117281 AA704160 AL597053 AI469571 AA911005 AA968724 AF394782 CA449088 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAPGEF6 expression in normal human tissues (normalized intensities)      RAPGEF6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RAPGEF6 Expression
    About this image


    RAPGEF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Medulla Oblongata
             ganglion/cranial/facial VII   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Testis (Reproductive System)
             sperm   

    See RAPGEF6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAPGEF6

    SOURCE GeneReport for Unigene cluster: Hs.483329

    UniProtKB/Swiss-Prot: RPGF6_HUMAN, Q8TEU7
    Tissue specificity: Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is
    barely detectable in skeletal muscle, kidney and pancreas

        SABiosciences Custom PCR Arrays for RAPGEF6
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RAPGEF6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAPGEF6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAPGEF6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEF6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAPGEF6 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rapgef61 , 5 Rap guanine nucleotide exchange factor (GEF) 61, 5 89.15(n)1
    91.61(a)1
      11 (32.13 cM)5
    1927861  NM_175258.41  NP_780467.21 
     545228475 
    chicken
    (Gallus gallus)
    Aves RAPGEF66
    Rap guanine nucleotide exchange factor (GEF) 6
    81(a)
    1 ↔ 1
    13(15796907-15904202)
    lizard
    (Anolis carolinensis)
    Reptilia RAPGEF66
    Rap guanine nucleotide exchange factor (GEF) 6
    79(a)
    1 ↔ 1
    2(128689357-128941628)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.283202 Xenopus laevis transcribed sequence with weak similarity more 81.94(n)    BJ082141.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rapgef61 Rap guanine nucleotide exchange factor (GEF) 6 65.19(n)
    72.48(a)
      335032  XM_002666094.2  XP_002666140.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gef266
    Gef26
    34(a)
    1 → many
    2L(6323767-6332789)
    worm
    (Caenorhabditis elegans)
    Secernentea pxf-16
    Protein PXF-1, isoform d
    33(a)
    1 → many
    IV(10164331-10174341)


    ENSEMBL Gene Tree for RAPGEF6 (if available)
    TreeFam Gene Tree for RAPGEF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAPGEF6 gene
    RAPGEFL12  RAPGEF22  RASGRP42  RASGRP12  RAPGEF32  RASGEF1A2  RAPGEF42  RASGEF1C2  
    RAPGEF52  RASGEF1B2  RASGRP22  RASGRP32  
    7 SIMAP similar genes for RAPGEF6 using alignment to 7 protein entries:     RPGF6_HUMAN (see all proteins):
    KIA001LB    FNIP1    DKFZp586O1422    RAPGEF2    PDZGEF1    RAPGEF4
    RAPGEF3

    RAPGEF6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RAPGEF6
    PGOHUM00000248515


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3896 SNPs in RAPGEF6 are shown (see all 3896)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710009981,2
    C--126123837(-) TGACT-/TAAAG 
            
    TAAGC
    6 -- int11Minor allele frequency- TAAAG:0.00NA 2
    rs1433551441,2
    C--130759192(+) TTGCGA/TAGAAA 4 -- int10--------
    rs1859745141,2
    --130759273(+) GCATCA/GTGGAG 4 -- int10--------
    rs1467635751,2
    --130759319(+) AGACTC/TTTCTA 4 -- int10--------
    rs1119952461,2
    C,F--130759457(+) CAGATG/TTGACA 4 -- int11Minor allele frequency- T:0.50CSA 2
    rs1445260261,2
    C--130759462(+) TGACA-/TTAACC 4 -- int10--------
    rs354249691,2
    C,F--130759464(+) GACATA/TACCAA 4 -- int11Minor allele frequency- T:0.00NA 2
    rs1998828461,2
    --130759464(+) ACATA-/TACCAA 4 -- int10--------
    rs1829712011,2
    --130759472(+) CAACAA/GCAAAT 4 -- int10--------
    rs1884414191,2
    --130759646(+) CAATGC/TATTAG 4 -- ut310--------

    HapMap Linkage Disequilibrium report for RAPGEF6 (130759614 - 130970929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for RAPGEF6 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730775CNV Deletion23290073
    esv2730777CNV Deletion23290073
    esv2730779CNV Deletion23290073
    esv2586698CNV Deletion19546169
    esv3284CNV Deletion18987735
    esv2730776CNV Deletion23290073
    esv2730774CNV Deletion23290073
    esv2730778CNV Deletion23290073
    esv273494CNV Insertion20981092
    esv1452882CNV Insertion17803354

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RAPGEF6
    DNA2.0 Custom Variant and Variant Library Synthesis for RAPGEF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610499    OMIM disorders: --

    2 diseases for RAPGEF6:    About MalaCards
    schizophrenia    


    RAPGEF6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAPGEF6
    Human Genome Epidemiology (HuGE) Navigator: RAPGEF6 (2 documents)

    Export disorders for RAPGEF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAPGEF6 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with RAPGEF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M- Ras. (PubMed id 11524421)1, 2, 3 Gao X.... Kataoka T. (2001)
    2. Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese. (PubMed id 18718982)1, 4 Luo X.J....Su B. (2008)
    3. Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. (PubMed id 18804346)1, 4 Edwards T.L....Chen X. (2008)
    4. Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. (PubMed id 12581858)1, 2 Kuiperij H.B.... Zwartkruis F.J.T. (2003)
    5. Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions. (PubMed id 12095257)1, 3 Kozlov G.... Ekiel I. (2002)
    6. Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration. (PubMed id 19176753)1, 9 Severson E.A....Parkos C.A. (2009)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. BAG3 directly associates with guanine nucleotide exch ange factor of Rap1, PDZGEF2, and regulates cell adhesion. (PubMed id 20800573)1 Iwasaki M....Takayama S. (2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions. (PubMed id 18585005)1 DubAc N....Bos J.L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51735 HGNC: 20655 AceView: RAPGEF6 Ensembl:ENSG00000158987 euGenes: HUgn51735
    ECgene: RAPGEF6 H-InvDB: RAPGEF6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAPGEF6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAPGEF6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAPGEF6 gene:
    Search GeneIP for patents involving RAPGEF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RAPGEF6  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for RAPGEF6   OriGene clones in human, mouse for RAPGEF6  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAPGEF6   OriGene Purified Protein for RAPGEF6  
     OriGene ORF clones in mouse, rat for RAPGEF6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAPGEF6   OriGene Custom Protein Services for RAPGEF6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAPGEF6
     QIAGEN SeqTarget long-range PCR primers for resequencing RAPGEF6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAPGEF6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAPGEF6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEF6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAPGEF6
     GenScript Custom Purified and Recombinant Proteins Services for RAPGEF6 GenScript cDNA clones with any tag delivered in your preferred vector for RAPGEF6
     GenScript Custom Assay Services for RAPGEF6 GenScript Custom Superior Antibodies Services for RAPGEF6
     GenScript Custom overexpressing Cell Line Services for RAPGEF6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RAPGEF6 promoter
     Search Chromatin IP Primers for RAPGEF6
     RT2 qPCR Primer Assay in human, mouse, rat RAPGEF6
     GNC Network for RAPGEF6
     SABiosciences Custom PCR Arrays for RAPGEF6
     Search Tocris compounds for RAPGEF6 (RPGF6)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RAPGEF6 antibodies
     RAPGEF6 proteins
     Antibodies for RAPGEF6
     See all of Abcam's Antibodies, Kits and Proteins for RAPGEF6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RAPGEF6
     Antibodies for RAPGEF6
     ELISAs for RAPGEF6
     CLIAs for RAPGEF6
     Search LifeMap BioReagents cell lines for RAPGEF6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF6
     SwitchGear 3'UTR luciferase reporter plasmids for RAPGEF6
     SwitchGear Promoter luciferase reporter plasmids for RAPGEF6
     Search ThermoFisher Antibodies for RAPGEF6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEF6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RAPGEF6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAPGEF6
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of RAPGEF6
     LSBio Antibodies in human, mouse, rat for RAPGEF6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAPGEF6 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4