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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAPGEF5 Gene

protein-coding   GIFtS: 60
GCID: GC07M022128

Rap Guanine Nucleotide Exchange Factor (GEF) 5

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rap Guanine Nucleotide Exchange Factor (GEF) 51 2     M-Ras-Regulated Rap GEF2 3
M-Ras-Regulated GEF1 2     REPAC2
Guanine Nucleotide Exchange Factor For Rap12 3     Rap Guanine Nucleotide Exchange Factor 52
Related To Epac2 3     KIAA02773
GFR2 3     MRGEF3
MR-GEF2 3     Repac3

External Ids:    HGNC: 168621   Entrez Gene: 97712   Ensembl: ENSG000001362377   OMIM: 6095275   UniProtKB: Q925653   

Export aliases for RAPGEF5 gene to outside databases

Previous GC identifers: GC07M021903 GC07M021931


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAPGEF5 Gene:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as
GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide
exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the
active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al.,
2000 (PubMed 10934204)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RAPGEF5 Gene: 
RAPGEF5 (Rap guanine nucleotide exchange factor (GEF) 5) is a protein-coding gene. Diseases associated with RAPGEF5 include lung cancer, and among its related super-pathways are G-protein signaling Rap1A regulation pathway and Development Angiotensin activation of ERK. GO annotations related to this gene include Rap guanyl-nucleotide exchange factor activity and GTP-dependent protein binding. An important paralog of this gene is RAPGEFL1.

UniProtKB/Swiss-Prot: RPGF5_HUMAN, Q92565
Function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS
inhibits Rap1 activation

Gene Wiki entry for RAPGEF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAPGEF5 gene promoter:
         NF-1   NF-1/L   p53   AP-1   MyoD   AP-4   C/EBPalpha   MZF-1   S8   CP2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RAPGEF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAPGEF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.3   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15.3

RAPGEF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAPGEF5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M022128:  view genomic region     (about GC identifiers)

Start:
22,157,856 bp from pter      End:
22,396,763 bp from pter
Size:
238,908 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 22,209,210-22,447,742     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPGF5_HUMAN, Q92565 (See protein sequence)
Recommended Name: Rap guanine nucleotide exchange factor 5  
Size: 580 amino acids; 67733 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAA13406.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for RAPGEF5:
1WGY (3D)    
Secondary accessions: A4D140 Q8IXU5
Alternative splicing: 2 isoforms:  Q92565-1   Q92565-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAPGEF5: NX_Q92565

Explore proteomics data for RAPGEF5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92565

  • RAPGEF5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAPGEF5 Protein Expression
    REFSEQ proteins: NP_036426.3  
    ENSEMBL proteins: 
     ENSP00000384044   ENSP00000415664   ENSP00000403956   ENSP00000395729   ENSP00000384870  
     ENSP00000343656  

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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for RAPGEF5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA10486569

    RAPGEF5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR008937 Ras_GEF
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR019804 Ras_G-nucl-exch_fac_CS
     IPR000651 Ras-like_Gua-exchang_fac_N

    Graphical View of Domain Structure for InterPro Entry Q92565

    ProtoNet protein and cluster: Q92565

    1 Blocks protein domain: IPB001895 Guanine-nucleotide dissociation stimulator CDC25

    UniProtKB/Swiss-Prot: RPGF5_HUMAN, Q92565
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 Ras-GEF domain


    RAPGEF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPGF5_HUMAN, Q92565
    Function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS
    inhibits Rap1 activation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005088Ras guanyl-nucleotide exchange factor activity TAS10934204
    GO:0017034Rap guanyl-nucleotide exchange factor activity IDA10486569
    GO:0030742GTP-dependent protein binding IPI10934204
         
    RAPGEF5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAPGEF5:
     Synthetic lethal with c-Myc af 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAPGEF5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap1A regulation pathway0.88
    2Development Angiotensin activation of ERK
    Development G-Proteins mediated regulation MARK-ERK signaling0.66
    3G-protein signaling Rap2B regulation pathway
    G-protein signaling Rap2B regulation pathway1.00
    4G-protein signaling Cross-talk between Ras-family GTPases
    G-protein signaling Cross-talk between Ras-family GTPases1.00
    5G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-12 signaling pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for RAPGEF5
        G-protein signaling Rap2B regulation pathway
    Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling Rap1A regulation pathway
    G-protein signaling G-Protein alpha-12 signaling pathway
    G-protein signaling Cross-talk between Ras-family GTPases


    5 GeneGo (Thomson Reuters) Pathways for RAPGEF5
        G-protein signaling Cross-talk between Ras-family GTPases
    G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap2B regulation pathway
    Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling G-Protein alpha-12 signaling pathway



    RAPGEF5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAPGEF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for RAPGEF5 (Q925653 ENSP000003436564) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MRASO148073, ENSP000002891044I2D: score=2 STRING: ENSP00000289104
    RAP2BP612253, ENSP000003190964I2D: score=1 STRING: ENSP00000319096
    RAP1AP628343, ENSP000003487864I2D: score=4 STRING: ENSP00000348786
    RAP2AP101143, ENSP000002453044I2D: score=3 STRING: ENSP00000245304
    PLAC9ENSP000003613374STRING: ENSP00000361337
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction NAS10486569
    GO:0007399nervous system development NAS10486569
    GO:0035556intracellular signal transduction ----
    GO:0051056regulation of small GTPase mediated signal transduction IEA--

    RAPGEF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAPGEF5 (RPGF5)

    3 HMDB Compounds for RAPGEF5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RAPGEF5 / RPGF5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAPGEF5 gene: 
    NM_012294.3  

    Unigene Cluster for RAPGEF5:

    Rap guanine nucleotide exchange factor (GEF) 5
    Hs.174768  [show with all ESTs]
    Unigene Representative Sequence: NM_012294
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401957(uc011jyl.1 uc011jym.1) ENST00000488366 ENST00000468825
    ENST00000458533 ENST00000451559 ENST00000420196 ENST00000475788 ENST00000405243
    ENST00000471484 ENST00000497668 ENST00000344041(uc003svg.3)
    miRNA
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    hsa-miR-520f hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-200a hsa-miR-219-5p hsa-miR-93 hsa-miR-3148
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    Additional mRNA sequence: 

    AK295859.1 AL833195.1 AL833229.1 BC039203.1 D87467.1 

    12 DOTS entries:

    DT.75113337  DT.448430  DT.100016735  DT.318042  DT.91749074  DT.121101282  DT.121101315  DT.405046 
    DT.91749075  DT.95377257  DT.318040  DT.75178057 

    24/205 AceView cDNA sequences (see all 205):

    AU140742 AA687472 AI168132 AA765623 BP349018 AA782145 AA889203 AI633934 
    AA844578 BE704111 AI050909 BF431833 AA928600 AA709401 AW235214 W56891 
    AW511225 AI651349 AW235464 W39730 AI825176 AA397989 AI982774 AI653399 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RAPGEF5 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                                      -     -                                                           -                       -                           
    SP2:                                      -     -                                         -     -     -     -     -                 -                           
    SP3:                                                                                                                                                            
    SP4:              -     -     -           -     -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21
    SP1:        -         
    SP2:        -         
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for RAPGEF5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAPGEF5 expression in normal human tissues (normalized intensities)      RAPGEF5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCTGCCT
    RAPGEF5 Expression
    About this image


    RAPGEF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 13 entries
             PureStem endothelial progenitor 30-SM2-1
             Human Ovarian Microvascular Endothelial Cells (HOMEC)   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Negative 3 Thymocytes Thymus
             PureStem endothelial Progenitor 30-SM2-3
     
     Lymph (Cardiovascular System)    fully expand to see all 2 entries
             Human Lymphatic Endothelial Cells (HLEC)   
     
     Dermis (Hematopoietic System)    fully expand to see all 2 entries
             Human Dermal Microvascular Endothelial Cells (HDMEC)   
     
     Smooth Muscle (Muscoskeletal System)
             Coronary Artery Smooth Muscle Cells (CASMC)   

    See RAPGEF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAPGEF5

    SOURCE GeneReport for Unigene cluster: Hs.174768

    UniProtKB/Swiss-Prot: RPGF5_HUMAN, Q92565
    Tissue specificity: Widely expressed with highest levels in brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAPGEF5 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rapgef51 , 5 Rap guanine nucleotide exchange factor (GEF) 51, 5 88.29(n)1
    92.32(a)1
      12 (63.06 cM)5
    2179441  NM_175930.51  NP_787126.31 
     1175164795 
    chicken
    (Gallus gallus)
    Aves LOC1008574621 rap guanine nucleotide exchange factor 5-like 77.88(n)
    79.67(a)
      100857462  XM_003640687.1  XP_003640735.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAPGEF56
    Uncharacterized protein
    70(a)
    1 ↔ 1
    6(30064905-30188876)
    zebrafish
    (Danio rerio)
    Actinopterygii wufk78a012 Transcribed sequence with moderate similarity to protein more 76.5(n)    57088135 
    fruit fly
    (Drosophila melanogaster)
    Insecta Epac6
    Epac
    25(a)
    1 → many
    2R(2647220-2686446)
    worm
    (Caenorhabditis elegans)
    Secernentea epac-16
    Rap guanine nucleotide exchange factor 1
    20(a)
    1 → many
    III(10189218-10195399)


    ENSEMBL Gene Tree for RAPGEF5 (if available)
    TreeFam Gene Tree for RAPGEF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAPGEF5 gene
    RAPGEFL12  RAPGEF22  RASGRP42  RAPGEF62  RASGRP12  RAPGEF32  RASGEF1A2  RAPGEF42  
    RASGEF1C2  RASGRP32  RASGEF1B2  RASGRP22  
    6 SIMAP similar genes for RAPGEF5 using alignment to 6 protein entries:     RPGF5_HUMAN (see all proteins):
    DKFZp667A016    Nbla00496    RAPGEF4    RAPGEFL1    CGEF2    RAPGEF3

    RAPGEF5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4756 SNPs in RAPGEF5 are shown (see all 4756)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs570929671,2
    C--22124620(+) AAAAA-/A/AAA 
            
    GGAAC
    1 -- int11NA 2
    rs1390327931,2
    --22157418(+) TTCCTA/GTTTAC 1 -- int10--------
    rs18598011,2
    C,F,O,H--22157423(+) GTTTAT/CACAGA 1 -- int118Minor allele frequency- C:0.43NS EA NA WA CSA 934
    rs1158923361,2
    C,F--22157491(+) CCCCAG/AAGCAT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1113571871,2
    C,F--22157651(+) AGGCAA/GTGACA 1 -- int12Minor allele frequency- G:0.03WA 120
    rs1163975301,2
    F--22157742(+) ACCCAA/GTGGCA 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1493471121,2
    --22157743(+) CCCAAC/TGGCAG 1 -- int10--------
    rs177074991,2
    C,F,H--22157782(+) CCTGAG/AAACCT 1 -- int128Minor allele frequency- A:0.28NA NS EA WA 2910
    rs1436655111,2
    --22157859(+) TGCTGC/TCAGAA 1 -- int10--------
    rs1481067061,2
    C--22157917(+) AGGCAG/TGAATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RAPGEF5 (22157856 - 22396763 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for RAPGEF5 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2333221CNV Deletion18987734
    esv1239094CNV Deletion17803354
    esv2734120CNV Deletion23290073
    esv2734118CNV Deletion23290073
    esv2661030CNV Deletion23128226
    esv4118CNV Deletion18987735
    esv2734119CNV Deletion23290073
    esv2665146CNV Deletion23128226
    nsv365300CNV Loss16902084
    nsv830923CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609527    OMIM disorders: --

    2 diseases for RAPGEF5:    About MalaCards
    lung cancer    


    RAPGEF5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAPGEF5
    Human Genome Epidemiology (HuGE) Navigator: RAPGEF5 (2 documents)

    Export disorders for RAPGEF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAPGEF5 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with RAPGEF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1. (PubMed id 10486569)1, 2, 3, 9 Ichiba T.... Kuraishi Y. (1999)
    2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T....Nomura N. (1996)
    3. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PubMed id 10934204)1, 2, 9 Rebhun J.F.... Quilliam L.A. (2000)
    4. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1, 4 Murea M....Freedman B.I. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)1, 4 Hwang S.J....Fox C.S. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    9. Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. (PubMed id 10777494)1, 2 de Rooij J....Bos J.L. (2000)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9771 HGNC: 16862 AceView: RAPGEF5 Ensembl:ENSG00000136237 euGenes: HUgn9771
    ECgene: RAPGEF5 H-InvDB: RAPGEF5

    (According to HUGE)
    About This Section
    HUGE: KIAA0277

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAPGEF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAPGEF5 gene:
    Search GeneIP for patents involving RAPGEF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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