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Aliases for RAPGEF5 Gene

Aliases for RAPGEF5 Gene

  • Rap Guanine Nucleotide Exchange Factor (GEF) 5 2 3
  • Guanine Nucleotide Exchange Factor For Rap1 3 4
  • M-Ras-Regulated Rap GEF 3 4
  • M-Ras-Regulated GEF 2 3
  • Related To Epac 3 4
  • MR-GEF 3 4
  • REPAC 3 4
  • GFR 3 4
  • Rap Guanine Nucleotide Exchange Factor 5 3
  • KIAA0277 4
  • MRGEF 4

External Ids for RAPGEF5 Gene

Summaries for RAPGEF5 Gene

Entrez Gene Summary for RAPGEF5 Gene

  • Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RAPGEF5 Gene

RAPGEF5 (Rap Guanine Nucleotide Exchange Factor (GEF) 5) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Ras signaling pathway. GO annotations related to this gene include Ras guanyl-nucleotide exchange factor activity and Rap guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGEF1B.

UniProtKB/Swiss-Prot for RAPGEF5 Gene

  • Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.

Gene Wiki entry for RAPGEF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAPGEF5 Gene

Genomics for RAPGEF5 Gene

Genomic Location for RAPGEF5 Gene

Start:
22,118,238 bp from pter
End:
22,357,144 bp from pter
Size:
238,907 bases
Orientation:
Minus strand

Genomic View for RAPGEF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAPGEF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAPGEF5 Gene

Regulatory Elements for RAPGEF5 Gene

Proteins for RAPGEF5 Gene

  • Protein details for RAPGEF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92565-RPGF5_HUMAN
    Recommended name:
    Rap guanine nucleotide exchange factor 5
    Protein Accession:
    Q92565
    Secondary Accessions:
    • A4D140
    • Q8IXU5

    Protein attributes for RAPGEF5 Gene

    Size:
    580 amino acids
    Molecular mass:
    67733 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13406.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAPGEF5 Gene

    Alternative splice isoforms for RAPGEF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAPGEF5 Gene

Proteomics data for RAPGEF5 Gene at MOPED

Post-translational modifications for RAPGEF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAPGEF5 Gene

No data available for DME Specific Peptides for RAPGEF5 Gene

Domains for RAPGEF5 Gene

UniProtKB/Swiss-Prot:

RPGF5_HUMAN
Domain:
  • Contains 1 N-terminal Ras-GEF domain.:
    • Q92565
  • Contains 1 Ras-GEF domain.:
    • Q92565
genes like me logo Genes that share domains with RAPGEF5: view

No data available for Gene Families for RAPGEF5 Gene

Function for RAPGEF5 Gene

Molecular function for RAPGEF5 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.

Gene Ontology (GO) - Molecular Function for RAPGEF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS 10934204
GO:0017034 Rap guanyl-nucleotide exchange factor activity IDA 10486569
GO:0030742 GTP-dependent protein binding IPI 10934204
genes like me logo Genes that share ontologies with RAPGEF5: view

Phenotypes for RAPGEF5 Gene

GenomeRNAi human phenotypes for RAPGEF5:
genes like me logo Genes that share phenotypes with RAPGEF5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RAPGEF5 Gene

Localization for RAPGEF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAPGEF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAPGEF5 Gene COMPARTMENTS Subcellular localization image for RAPGEF5 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RAPGEF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 10486569
genes like me logo Genes that share ontologies with RAPGEF5: view

Pathways for RAPGEF5 Gene

genes like me logo Genes that share pathways with RAPGEF5: view

Gene Ontology (GO) - Biological Process for RAPGEF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction NAS 10486569
GO:0007399 nervous system development NAS 10486569
GO:0035556 intracellular signal transduction --
GO:0043547 positive regulation of GTPase activity TAS 10934204
GO:0051056 regulation of small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAPGEF5: view

Compounds for RAPGEF5 Gene

(3) HMDB Compounds for RAPGEF5 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RAPGEF5: view

Transcripts for RAPGEF5 Gene

Unigene Clusters for RAPGEF5 Gene

Rap guanine nucleotide exchange factor (GEF) 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAPGEF5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - -
SP2: - - - - - - - -
SP3:
SP4: - - - - -
SP5:
SP6: -
SP7:

ExUns: 19 ^ 20 ^ 21
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for RAPGEF5 Gene

GeneLoc Exon Structure for
RAPGEF5
ECgene alternative splicing isoforms for
RAPGEF5

Expression for RAPGEF5 Gene

mRNA expression in normal human tissues for RAPGEF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAPGEF5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (9.2) and Brain - Substantia nigra (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAPGEF5 Gene

SOURCE GeneReport for Unigene cluster for RAPGEF5 Gene Hs.174768

mRNA Expression by UniProt/SwissProt for RAPGEF5 Gene

Q92565-RPGF5_HUMAN
Tissue specificity: Widely expressed with highest levels in brain
genes like me logo Genes that share expressions with RAPGEF5: view

Orthologs for RAPGEF5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAPGEF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAPGEF5 36
  • 99.68 (n)
  • 99.73 (a)
RAPGEF5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAPGEF5 36
  • 90.32 (n)
  • 93.97 (a)
RAPGEF5 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAPGEF5 36
  • 92.42 (n)
  • 95.62 (a)
RAPGEF5 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rapgef5 36
  • 88.22 (n)
  • 92.19 (a)
Rapgef5 16
Rapgef5 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAPGEF5 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAPGEF5 37
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAPGEF5 36
  • 77.87 (n)
  • 79.56 (a)
RAPGEF5 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAPGEF5 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rapgef5 36
  • 75.14 (n)
  • 75.83 (a)
zebrafish
(Danio rerio)
Actinopterygii rapgef5a 36
  • 62.73 (n)
  • 62.61 (a)
rapgef5a 37
  • 65 (a)
OneToMany
rapgef5b 37
  • 46 (a)
OneToMany
wufk78a01 36
fruit fly
(Drosophila melanogaster)
Insecta Epac 37
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea epac-1 37
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUD5 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToMany
Species with no ortholog for RAPGEF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAPGEF5 Gene

ENSEMBL:
Gene Tree for RAPGEF5 (if available)
TreeFam:
Gene Tree for RAPGEF5 (if available)

Paralogs for RAPGEF5 Gene

Selected SIMAP similar genes for RAPGEF5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAPGEF5: view

Variants for RAPGEF5 Gene

Sequence variations from dbSNP and Humsavar for RAPGEF5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1419764 -- 22,234,576(+) CATAT(A/G)CTTTG intron-variant
rs1419760 -- 22,231,297(+) GCTGG(A/C)AGTTT intron-variant
rs1419759 -- 22,217,369(+) GAAAG(C/T)GAGGA intron-variant
rs1419758 -- 22,165,923(+) taatc(C/T)tcctc intron-variant
rs1419757 -- 22,165,881(+) CACGG(C/T)CTCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAPGEF5 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
esv2665146 CNV Deletion 23128226
esv2734118 CNV Deletion 23290073
esv2333221 CNV Deletion 18987734
esv4118 CNV Deletion 18987735
esv2734119 CNV Deletion 23290073
esv1239094 CNV Deletion 17803354
nsv365300 CNV Loss 16902084
esv2734120 CNV Deletion 23290073
esv2661030 CNV Deletion 23128226
nsv830923 CNV Gain 17160897

Relevant External Links for RAPGEF5 Gene

HapMap Linkage Disequilibrium report
RAPGEF5

Disorders for RAPGEF5 Gene

Relevant External Links for RAPGEF5

Genetic Association Database (GAD)
RAPGEF5
Human Genome Epidemiology (HuGE) Navigator
RAPGEF5
genes like me logo Genes that share disorders with RAPGEF5: view

No data available for UniProtKB/Swiss-Prot for RAPGEF5 Gene

Publications for RAPGEF5 Gene

  1. Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1. (PMID: 10486569) Ichiba T. … Kuraishi Y. (FEBS Lett. 1999) 2 3 4 23
  2. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PMID: 10934204) Rebhun J.F. … Quilliam L.A. (J. Biol. Chem. 2000) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  4. Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. (PMID: 10777494) de Rooij J. … Bos J.L. (J. Biol. Chem. 2000) 3 4
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4

Products for RAPGEF5 Gene

Sources for RAPGEF5 Gene

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