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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RAPGEF5 Gene

protein-coding GIFtS: 60
GCID: GC07M022128

Rap guanine nucleotide exchange factor (GEF) 5

Explore 1 disease affiliated with
RAPGEF5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rap Guanine Nucleotide Exchange Factor (GEF) 5¹ ²		M-Ras-Regulated Rap GEF² ³
GFR¹ ² ³		REPAC²
MR-GEF¹ ² ³		M-Ras-Regulated GEF²
KIAA0277¹ ³		Rap Guanine Nucleotide Exchange Factor 5²
Guanine Nucleotide Exchange Factor For Rap1² ³		MRGEF³
Related To Epac² ³		Repac³

External Ids:	HGNC: 16862¹	Entrez Gene: 9771²	Ensembl: ENSG00000136237⁷	OMIM: 609527⁵	UniProtKB: Q92565³

Export aliases for RAPGEF5 gene to outside databases

Previous GC identifers: GC07M021903 GC07M021931

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAPGEF5:

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated

switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs),

such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and

are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).(supplied

by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: RPGF5_HUMAN, Q92565

Function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS

inhibits Rap1 activation

Gene Wiki entry for RAPGEF5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RAPGEF5 gene promoter:
NF-1 NF-1/L p53 AP-1 MyoD AP-4 C/EBPalpha MZF-1 S8 CP2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for RAPGEF5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAPGEF5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.3 Ensembl cytogenetic band: 7p15.3 HGNC cytogenetic band: 7p15.3

RAPGEF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAPGEF5 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M022128: view genomic region (about GC identifiers)

Start:	22,157,908 bp from pter	End:	22,396,763 bp from pter
Size:	238,856 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 22,209,210-22,447,742

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RPGF5_HUMAN, Q92565 (See protein sequence)

Recommended Name: Rap guanine nucleotide exchange factor 5

Size: 580 amino acids; 67733 Da

Subcellular location: Nucleus

Sequence caution: Sequence=BAA13406.2; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for RAPGEF5:

1WGY (3D)

Secondary accessions: A4D140 Q8IXU5

Alternative splicing: 2 isoforms: Q92565-1 Q92565-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAPGEF5: NX_Q92565

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92565

RAPGEF5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036426.3

ENSEMBL proteins:

ENSP00000384044 ENSP00000415664 ENSP00000403956 ENSP00000395729 ENSP00000384870

ENSP00000343656

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RAPGEF5

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	10486569

RAPGEF5 for ontologies About GeneDecksing

RAPGEF5 Antibody Products:

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	GenScript Custom Assay Services for RAPGEF5
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	Uscn ELISAs and CLIAs for RAPGEF5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RAPGEF5 for domains About GeneDecksing

5 InterPro domains/families:

IPR008937 Ras_GEF

IPR023578 Ras_GEF_dom

IPR001895 RasGRF_CDC25

IPR019804 Ras_G-nucl-exch_fac_CS

IPR000651 Ras-like_Gua-exchang_fac_N

Graphical View of Domain Structure for InterPro Entry Q92565

ProtoNet protein and cluster: Q92565

1 Blocks protein family: IPB001895 Guanine-nucleotide dissociation stimulator CDC25

UniProtKB/Swiss-Prot: RPGF5_HUMAN, Q92565

Similarity: Contains 1 N-terminal Ras-GEF domain

Similarity: Contains 1 Ras-GEF domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RPGF5_HUMAN, Q92565

Function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS

inhibits Rap1 activation

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAPGEF5
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		hsa-miR-520f hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-200a hsa-miR-219-5p hsa-miR-93 hsa-miR-3148

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing
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		Search LifeMap BioReagents cell lines for RAPGEF5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF5

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	--	--
GO:0005088	Ras guanyl-nucleotide exchange factor activity	TAS	10934204
GO:0017034	Rap guanyl-nucleotide exchange factor activity	IDA	10486569
GO:0030742	GTP-dependent protein binding	IPI	10934204

RAPGEF5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for RAPGEF5:

Synthetic lethal with c-Myc af

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling Rap1A regulation pathway

G-protein signaling Rap1A regulation pathway

1.00

G-protein signaling_Rap1A regulation pathway

0.88

Development Angiotensin activation of ERK

Development G-Proteins mediated regulation MARK-ERK signaling

0.66

Development_G-Proteins mediated regulation MARK-ERK signaling

0.66

G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins

G-protein signaling G-Protein alpha-12 signaling pathway

0.40

G-protein signaling_G-Protein alpha-12 signaling pathway

0.40

IL-9 Signaling Pathways

G-protein signaling_Cross-talk between Ras-family GTPases

0.14

G-protein signaling Cross-talk between Ras-family GTPases

0.14

G-protein signaling_RhoA regulation pathway

G-protein signaling Rap2B regulation pathway

0.04

G-protein signaling_Rap2B regulation pathway

0.04

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for RAPGEF5

	G-protein signaling Rap2B regulation pathway
	Development G-Proteins mediated regulation MARK-ERK signaling
	G-protein signaling Rap1A regulation pathway
	G-protein signaling G-Protein alpha-12 signaling pathway
	G-protein signaling Cross-talk between Ras-family GTPases

5 GeneGo (Thomson Reuters) Pathways for RAPGEF5

	G-protein signaling Cross-talk between Ras-family GTPases
	G-protein signaling Rap1A regulation pathway
	G-protein signaling Rap2B regulation pathway
	Development G-Proteins mediated regulation MARK-ERK signaling
	G-protein signaling G-Protein alpha-12 signaling pathway

RAPGEF5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RAPGEF5

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for RAPGEF5 (Q92565³ ENSP00000343656⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MRAS	O14807³, ENSP00000289104⁴	I2D: score=2 STRING: ENSP00000289104
RAP2B	P61225³, ENSP00000319096⁴	I2D: score=1 STRING: ENSP00000319096
RAP1A	P62834³, ENSP00000348786⁴	I2D: score=4 STRING: ENSP00000348786
RAP2A	P10114³, ENSP00000245304⁴	I2D: score=3 STRING: ENSP00000245304
PLAC9	ENSP00000361337⁴	STRING: ENSP00000361337

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	NAS	10486569
GO:0007399	nervous system development	NAS	10486569
GO:0035556	intracellular signal transduction	--	--
GO:0051056	regulation of small GTPase mediated signal transduction	IEA	--

RAPGEF5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RAPGEF5

3 HMDB Compounds for RAPGEF5 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about RAPGEF5 / RPGF5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RAPGEF5 gene:

NM_012294.3

Unigene Cluster for RAPGEF5:

Rap guanine nucleotide exchange factor (GEF) 5

Hs.174768 [show with all ESTs]

Unigene Representative Sequence: NM_012294

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000401957(uc011jyl.1 uc011jym.1) ENST00000488366 ENST00000468825

ENST00000458533 ENST00000451559 ENST00000420196 ENST00000475788 ENST00000405243

ENST00000471484 ENST00000497668 ENST00000344041(uc003svg.3)

miRNA Products:		OriGene 3'-UTR Clone: RAPGEF5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAPGEF5
		8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate RAPGEF5 (see all 87):
		hsa-miR-520f hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-200a hsa-miR-219-5p hsa-miR-93 hsa-miR-3148

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAPGEF5 (see all 7) OriGene shRNA RFP: RAPGEF5 OriGene siRNA: RAPGEF5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAPGEF5

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		GenScript: all cDNA clones in your preferred vector: RAPGEF5 (NM_012294)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAPGEF5
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAPGEF5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEF5

Additional cDNA sequence:

AK295859.1 AL833195.1 AL833229.1 BC039203.1 D87467.1

12 DOTS entries:

DT.75113337 DT.448430 DT.100016735 DT.318042 DT.91749074 DT.121101282 DT.121101315 DT.405046

DT.91749075 DT.95377257 DT.318040 DT.75178057

24/205 AceView cDNA sequences (see all 205):

BF431833 AW235214 AA928600 AA709401 W56891 AW235464 AW511225 W39730

AA397989 AI982774 AI653399 AI651349 AI825176 AA838830 BX098379 AL833195

AL833229 BP349018 AI001830 AA782145 AI633934 AA889203 AA844578 AI050909

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RAPGEF5 (see all 7) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	^	16	^	17a	·	17b	^	18	^
SP1:													-		-																				-								-
SP2:													-		-														-		-		-		-		-						-
SP3:
SP4:					-		-		-				-		-
SP5:

ExUns:	19	^	20	^	21
SP1:			-
SP2:			-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RAPGEF5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAPGEF5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCTGCCT

About this image

RAPGEF5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RAPGEF5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAPGEF5

SOURCE GeneReport for Unigene cluster: Hs.174768

UniProtKB/Swiss-Prot: RPGF5_HUMAN, Q92565

Tissue specificity: Widely expressed with highest levels in brain

SABiosciences Custom PCR Arrays for RAPGEF5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAPGEF5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEF5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RAPGEF5 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100857462¹	rap guanine nucleotide exchange factor 5-like	77.88(n) 79.67(a)		100857462 XM_003640687.1 XP_003640735.1
lizard (Anolis carolinensis)	Reptilia	RAPGEF5⁶	--	70(a)	1 ↔ 1	6(30069703-30188876)
zebrafish (Danio rerio)	Actinopterygii	wufk78a01²	Transcribed sequence with moderate similarity to protein more	76.5(n)		57088135
fruit fly (Drosophila melanogaster)	Insecta	Epac⁶	Epac	25(a)	1 → many	2R(2647220-2686446)
worm (Caenorhabditis elegans)	Secernentea	epac-1⁶	Rap guanine nucleotide exchange factor 1	21(a)	1 → many	III(10189127-10195308)

ENSEMBL Gene Tree for RAPGEF5 (if available)
TreeFam Gene Tree for RAPGEF5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RAPGEF5 gene

RAPGEF2² RAPGEFL1² RAPGEF6² RASGEF1A² RAPGEF3² RASGEF1C² RAPGEF4² RASGEF1B²

6 SIMAP similar genes for RAPGEF5 using alignment to 6 protein entries: RPGF5_HUMAN (see all proteins):

DKFZp667A016 Nbla00496 RAPGEF4 RAPGEFL1 CGEF2 RAPGEF3

RAPGEF5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139032793^1,2		--	22157418(+)	`TTCCTA/GTTTAC`	1	--	int¹		0	--	--	--	--
rs1859801^1,2	C,F,O,H,	--	22157423(+)	`GTTTAT/CACAGA`	1	--	int¹		18		NS EA NA WA CSA	934
rs115892336^1,2	C,F,	--	22157491(+)	`CCCCAG/AAGCAT`	1	--	int¹		1		WA	118
rs111357187^1,2	C,	--	22157651(+)	`AGGCAA/GTGACA`	1	--	int¹		2		WA	120
rs116397530^1,2		--	22157742(+)	`ACCCAA/GTGGCA`	1	--	int¹		1		WA	118
rs149347112^1,2		--	22157743(+)	`CCCAAC/TGGCAG`	1	--	int¹		0	--	--	--	--
rs17707499^1,2	C,F,H,	--	22157782(+)	`CCTGAG/AAACCT`	1	--	int¹		28		NA NS EA WA	2910
rs143665511^1,2		--	22157859(+)	`TGCTGC/TCAGAA`	1	--	int¹		0	--	--	--	--
rs148106706^1,2		--	22157917(+)	`AGGCAG/TGAATA`	1	--	ut3¹		0	--	--	--	--
rs3837089^1,2	C,	--	22157962(-)	`TTTTT-/TAAAAC`	1	--	ut3¹		3		NA CSA	6

HapMap Linkage Disequilibrium report for RAPGEF5 (22157908 - 22396763 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for RAPGEF5
4 Indels: 41538 28604 12914 40961

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RAPGEF5 for disorders           About GeneDecksing

OMIM gene information: 609527    OMIM disorders: --

1 disease for RAPGEF5:    About MalaCards

lung cancer

Human Genome Epidemiology (HuGE) Navigator: RAPGEF5 (2 documents)

Export disorders for RAPGEF5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RAPGEF5 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with RAPGEF5)

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world of online information

Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1. (PubMed id 10486569)^{1, 2, 3, 9} Ichiba T.... Kuraishi Y. (1999)
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{1, 2, 3} Nagase T....Nomura N. (1996)
Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PubMed id 10934204)^{1, 2, 9} Rebhun J.F.... Quilliam L.A. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. (PubMed id 10777494)^{1, 2} de Rooij J....Bos J.L. (2000)
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)¹ Murea M....Freedman B.I. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)¹ Hwang S.J....Fox C.S. (2007)
Voltage-gated ion channel Kv4.3 is associated with Rap guanine nucleotide exchange factors and regulates angiotensin receptor type 1 signaling to small G-protein Rap. (PubMed id 17725712)¹ Potapova I.A....Doronin S.V. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9771	HGNC: 16862	AceView: RAPGEF5	Ensembl:ENSG00000136237	euGenes: HUgn9771
ECgene: RAPGEF5	H-InvDB: RAPGEF5

(According to HUGE)
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HUGE: KIAA0277

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RAPGEF5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RAPGEF5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RAPGEF5 gene:
Search GeneIP for patents involving RAPGEF5

GeneCards and IP:
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Rap guanine nucleotide exchange factor (GEF) 5

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Rap guanine nucleotide exchange factor (GEF) 5

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