Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAPGEF3 Gene

protein-coding   GIFtS: 66
GCID: GC12M048128

Rap Guanine Nucleotide Exchange Factor (GEF) 3

(Previous name: RAP guanine-nucleotide-exchange factor (GEF) 3)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rap Guanine Nucleotide Exchange Factor (GEF) 31 2     RAP Guanine-Nucleotide-Exchange Factor (GEF) 31
Exchange Protein Directly Activated By CAMP 11 2 3     9330170P05Rik2
EPAC2 3 5     CAMP-GEFI2
Exchange Factor Directly Activated By CAMP 12 3     HSU792752
EPAC12 3     bcm9102
CAMP-Regulated Guanine Nucleotide Exchange Factor I2 3     Rap Guanine Nucleotide Exchange Factor 32
EPAC 12 3     CGEF13
Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CAMP2 3     cAMP-GEFI3

External Ids:    HGNC: 166291   Entrez Gene: 104112   Ensembl: ENSG000000793377   OMIM: 6060575   UniProtKB: O953983   

Export aliases for RAPGEF3 gene to outside databases

Previous GC identifers: GC12M046418 GC12M046419 GC12M045159


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RAPGEF3 Gene: 
RAPGEF3 (Rap guanine nucleotide exchange factor (GEF) 3) is a protein-coding gene. Diseases associated with RAPGEF3 include follicular adenoma, and nicotine dependence, and among its related super-pathways are Regulation of Insulin Secretion and Platelet Aggregation (Plug Formation). GO annotations related to this gene include cAMP binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RAPGEFL1.

UniProtKB/Swiss-Prot: RPGF3_HUMAN, O95398
Function: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding
cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it
activates the PI3K gamma complex and which is involved in angiogenesis

summary for RAPGEF3 Gene:
GTPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate
(GTP) to form guanine diphosphate (GDP). Mg2+ is essential for catalytic activity. GTPases are often coupled
to G proteins and have essential roles in signal transduction, protein synthesis and translocation, control
of cell growth and differentiation and vesicular transport regulation.

Gene Wiki entry for RAPGEF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAPGEF3 gene promoter:
         Sp1   YY1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAPGEF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAPGEF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAPGEF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.1   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.1

RAPGEF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAPGEF3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048128:  view genomic region     (about GC identifiers)

Start:
48,128,453 bp from pter      End:
48,164,823 bp from pter
Size:
36,371 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPGF3_HUMAN, O95398 (See protein sequence)
Recommended Name: Rap guanine nucleotide exchange factor 3  
Size: 923 amino acids; 103751 Da
Subunit: Interacts with PDE3B
Subcellular location: Endomembrane system
Caution: It is uncertain whether Met-1 or Met-43 is the initiator
Sequence caution: Sequence=AAD02890.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD12740.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K2G5 E7EQC8 O95634 Q8WVN0
Alternative splicing: 3 isoforms:  O95398-1   O95398-2   O95398-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for RAPGEF3: NX_O95398

Explore proteomics data for RAPGEF3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95398

  • RAPGEF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAPGEF3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001092001.1  NP_001092002.1  NP_006096.2  

    ENSEMBL proteins: 
     ENSP00000395708   ENSP00000449905   ENSP00000448619   ENSP00000373864   ENSP00000448480  
     ENSP00000447691   ENSP00000378764   ENSP00000449818   ENSP00000446731   ENSP00000448804  
     ENSP00000384521   ENSP00000171000  
    Reactome Protein details: O95398
    Human Recombinant Protein Products for RAPGEF3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RAPGEF3
    OriGene Protein Over-expression Lysate for RAPGEF3
    OriGene MassSpec for RAPGEF3 
    OriGene Custom Protein Services for RAPGEF3
    GenScript Custom Purified and Recombinant Proteins Services for RAPGEF3
    Novus Biologicals RAPGEF3 Proteins
    Novus Biologicals RAPGEF3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAPGEF3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane TAS--
    GO:0005952cAMP-dependent protein kinase complex IEA--
    GO:0012505endomembrane system IEA--
    GO:0016020membrane TAS10777494

    RAPGEF3 for ontologies           About GeneDecksing



    RAPGEF3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RAPGEF3  (Epac1)
    OriGene Antibodies for RAPGEF3
    OriGene Custom Antibody Services for RAPGEF3
    GenScript Custom Superior Antibodies Services for RAPGEF3
    Novus Biologicals RAPGEF3 Antibodies
    Abcam antibodies for RAPGEF3
    Cloud-Clone Corp. Antibodies for RAPGEF3 
    ThermoFisher Antibodies for RAPGEF3
    LSBio Antibodies in human, mouse, rat for RAPGEF3 

    Assay Products for RAPGEF3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAPGEF3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAPGEF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAPGEF3 
    Cloud-Clone Corp. CLIAs for RAPGEF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Epac1 
    Exchange protein activated by cyclic AMP (Epac)

    5/11 InterPro protein domains (see all 11):
     IPR008937 Ras_GEF
     IPR018490 cNMP-bd-like
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000595 cNMP-bd_dom

    Graphical View of Domain Structure for InterPro Entry O95398

    ProtoNet protein and cluster: O95398

    4 Blocks protein domains:
    IPB000591 Pleckstrin putative G-protein interacting domain
    IPB000595 Cyclic nucleotide-binding domain
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25
    IPB002373 cAMP-dependent protein kinase signature


    UniProtKB/Swiss-Prot: RPGF3_HUMAN, O95398
    Domain: The DEP domain is involved in membrane localization independent from regulation by cAMP
    Similarity: Contains 1 cyclic nucleotide-binding domain
    Similarity: Contains 1 DEP domain
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 Ras-GEF domain


    RAPGEF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPGF3_HUMAN, O95398
    Function: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding
    cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it
    activates the PI3K gamma complex and which is involved in angiogenesis

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity TAS9853756
    GO:0005515protein binding IPI--
    GO:0008603cAMP-dependent protein kinase regulator activity IEA--
    GO:0017034Rap guanyl-nucleotide exchange factor activity IMP--
    GO:0030552cAMP binding IEA--
         
    RAPGEF3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAPGEF3:
     Increased telomerase activity 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rapgef3):
     cellular  nervous system  no phenotypic analysis 

    RAPGEF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rapgef3tm1Utak for RAPGEF3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAPGEF3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAPGEF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAPGEF3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAPGEF3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAPGEF3
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate RAPGEF3 (see all 14):
    hsa-miR-345 hsa-miR-1178 hsa-miR-1266 hsa-miR-3194-5p hsa-miR-550a hsa-miR-539 hsa-miR-4268 hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidRAPGEF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAPGEF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAPGEF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAPGEF3
    Sirion Biotech Customized adenovirus for overexpression of RAPGEF3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RAPGEF3 (see all 18)
    OriGene ORF clones in mouse, rat for RAPGEF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RAPGEF3 (NM_001098531)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAPGEF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEF3
    Sirion Biotech Customized lentivirus for stable overexpression of RAPGEF3 
                         Customized lentivirus expression plasmids for stable overexpression of RAPGEF3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAPGEF3
    Search LifeMap BioReagents cell lines for RAPGEF3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAPGEF3 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of Insulin Secretion
    Regulation of Insulin Secretion0.74
    Regulation of Insulin Secretion by Glucagon-like Peptide-10.55
    Integration of energy metabolism0.74
    2Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    Platelet Aggregation (Plug Formation)0.73
    3Immune System
    Immune System0.56
    Adaptive Immune System0.56
    4G-protein signaling G-Protein alpha-i signaling cascades
    Development Beta-adrenergic receptors regulation of ERK0.55
    G-protein signaling G-Protein alpha-s signaling cascades0.44
    5Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for RAPGEF3 (see all 7)
        Development Beta-adrenergic receptors regulation of ERK
    Development A2A receptor signaling
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction cAMP signaling
    Development G-Proteins mediated regulation MARK-ERK signaling


    2 Cell Signaling Technology (CST) Pathways for RAPGEF3
        Ca, cAMP and Lipid Signaling
    Cytoskeletal Signaling

    5/7 GeneGo (Thomson Reuters) Pathways for RAPGEF3 (see all 7)
        G-protein signaling G-Protein alpha-s signaling cascades
    Development A2A receptor signaling
    G-protein signaling Rap1A regulation pathway
    Development A2B receptor- action via G-protein alpha s
    Signal transduction cAMP signaling

    1 BioSystems Pathway for RAPGEF3
        Integrated Pancreatic Cancer Pathway

    5/13        Reactome Pathways for RAPGEF3 (see all 13)
        Hemostasis
    Integrin cell surface interactions
    Metabolism
    Regulation of Insulin Secretion
    Adaptive Immune System


    3         Kegg Pathways  (Kegg details for RAPGEF3):
        Leukocyte transendothelial migration
    Long-term potentiation
    Serotonergic synapse


    RAPGEF3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAPGEF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for RAPGEF3 (O953981, 2, 3 ENSP000003957084) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAP1BP612242, 3, ENSP000002505594MINT-6741806 I2D: score=1 STRING: ENSP00000250559
    RAP1AP628343, ENSP000003487864I2D: score=1 STRING: ENSP00000348786
    PDE3BQ133701, ENSP000002820964EBI-6172806,EBI-6172856 STRING: ENSP00000282096
    GNAI1ENSP000003430274STRING: ENSP00000343027
    GNAI2ENSP000003129994STRING: ENSP00000312999
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006112energy reserve metabolic process TAS--
    GO:0007165signal transduction TAS9853756
    GO:0007264small GTPase mediated signal transduction ----
    GO:0007596blood coagulation TAS--

    RAPGEF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAPGEF3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for RAPGEF3

    Compounds for RAPGEF3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HJC 0350Selective Epac2 inhibitor[885434-70-8]
    Dynamin inhibitory peptide, myristoylated (control) Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775) --
    8CPT-2Me-cAMP, sodium salt Selective Epac activator[510774-50-2]
    DynasoreNon-competitive dynamin inhibitor[304448-55-3]
    ML 141Selective inhibitor of Cdc42 Rho family GTPase[71203-35-5]

    4 HMDB Compounds for RAPGEF3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    10/15 Novoseek inferred chemical compound relationships for RAPGEF3 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 70 78 15591041 (5), 15525573 (4), 18391018 (3), 19307703 (3) (see all 23)
    forskolin 69.3 9 17565009 (2), 15525573 (2), 16172130 (2), 12960055 (1) (see all 7)
    ryanodine 41.3 1 18957419 (1)
    guanine 38.3 3 17993260 (1), 16269655 (1), 12819211 (1)
    calcium 37 25 18957419 (3), 16837018 (2), 11292831 (1), 17957381 (1) (see all 11)
    adenylate 35.1 1 17284589 (1)
    gdp 33.8 5 19546222 (2), 14615375 (1), 16728394 (1)
    gtp 31.9 13 18495429 (2), 12783872 (1), 19546222 (1), 17178726 (1)
    pge1 26.8 3 15967167 (2)
    phosphatidylinositol 21.7 2 11801596 (1), 12960055 (1)

    Search CenterWatch for drugs/clinical trials and news about RAPGEF3 / RPGF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAPGEF3 gene (3 alternative transcripts): 
    NM_001098531.2  NM_001098532.2  NM_006105.5  

    Unigene Cluster for RAPGEF3:

    Rap guanine nucleotide exchange factor (GEF) 3
    Hs.8578  [show with all ESTs]
    Unigene Representative Sequence: NM_001098531
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000449771 ENST00000547856 ENST00000549151 ENST00000395360 ENST00000482843
    ENST00000479866 ENST00000488250 ENST00000389212 ENST00000548919 ENST00000490387
    ENST00000548434 ENST00000473777 ENST00000476259 ENST00000395358(uc001rqa.3)
    ENST00000494764 ENST00000495465 ENST00000466322 ENST00000495953

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAPGEF3
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate RAPGEF3 (see all 14):
    hsa-miR-345 hsa-miR-1178 hsa-miR-1266 hsa-miR-3194-5p hsa-miR-550a hsa-miR-539 hsa-miR-4268 hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidRAPGEF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAPGEF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAPGEF3
    Clone
    Products:
         
    OriGene clones in human, mouse for RAPGEF3 (see all 18)
    OriGene ORF clones in mouse, rat for RAPGEF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RAPGEF3 (NM_001098531)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAPGEF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEF3
    Sirion Biotech Customized lentivirus for stable overexpression of RAPGEF3 
                         Customized lentivirus expression plasmids for stable overexpression of RAPGEF3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RAPGEF3
    OriGene qSTAR qPCR primer pairs in human, mouse for RAPGEF3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAPGEF3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAPGEF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEF3

    Additional mRNA sequence: 

    AF103905.1 AK092448.1 AK125545.1 AK290230.1 AK299029.1 AK308079.1 BC017728.1 BC092404.1 
    U78168.1 U78169.1 U79275.1 

    12 DOTS entries:

    DT.101963950  DT.92016399  DT.410511  DT.121171772  DT.100744578  DT.111018  DT.101942  DT.95166221 
    DT.102843210  DT.435797  DT.121171795  DT.95166219 

    24/91 AceView cDNA sequences (see all 91):

    BQ775848 R49966 AL598685 BG822090 BQ711010 CD515786 AK055502 BU728130 
    AW003615 CA427944 AW801798 BQ007070 NM_006105 BX509905 BP349451 BX115615 
    BU151157 BE394226 BI000902 CA306721 BI913941 BG823739 CD656706 BC068477 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RAPGEF3 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:              -     -                                                                             -                                         -               
    SP2:              -     -                                                                                                                       -               
    SP3:                                -     -     -     -     -     -                                   -                                         -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b · 20c ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c · 29d
    SP1:  -     -                                                                                       
    SP2:  -     -                 -                                                                     
    SP3:  -     -                                                                                       
    SP4:  -     -                                                                                       
    SP5:                                                                                                


    ECgene alternative splicing isoforms for RAPGEF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAPGEF3 expression in normal human tissues (normalized intensities)      RAPGEF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGGGGCT
    RAPGEF3 Expression
    About this image


    RAPGEF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 5 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
             skeletal muscle ; myocytes   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             corpus callosum   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   

    See RAPGEF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAPGEF3

    SOURCE GeneReport for Unigene cluster: Hs.8578

    UniProtKB/Swiss-Prot: RPGF3_HUMAN, O95398
    Tissue specificity: Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal
    kidney

        SABiosciences Custom PCR Arrays for RAPGEF3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RAPGEF3
    OriGene qSTAR qPCR primer pairs in human, mouse for RAPGEF3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAPGEF3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAPGEF3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAPGEF3 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rapgef31 , 5 Rap guanine nucleotide exchange factor (GEF) 31, 5 87.97(n)1
    91.01(a)1
      15 (53.74 cM)5
    2238641  NM_001177810.11  NP_001171281.11 
     977447705 
    chicken
    (Gallus gallus)
    Aves RAPGEF31 Rap guanine nucleotide exchange factor (GEF) 3 70.06(n)
    68.38(a)
      426888  XM_424494.3  XP_424494.3 
    lizard
    (Anolis carolinensis)
    Reptilia RAPGEF36
    Rap guanine nucleotide exchange factor (GEF) 3
    65(a)
    1 ↔ 1
    GL343252.1(1274524-1352659)
    zebrafish
    (Danio rerio)
    Actinopterygii rapgef36
    Rap guanine nucleotide exchange factor (GEF) 3
    55(a)
    1 ↔ 1
    23(33588106-33657726)
    fruit fly
    (Drosophila melanogaster)
    Insecta Epac6
    Epac
    35(a)
    1 → many
    2R(2647220-2686446)
    worm
    (Caenorhabditis elegans)
    Secernentea epac-16
    Rap guanine nucleotide exchange factor 1
    28(a)
    1 → many
    III(10189218-10195399)


    ENSEMBL Gene Tree for RAPGEF3 (if available)
    TreeFam Gene Tree for RAPGEF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAPGEF3 gene
    RAPGEFL12  RAPGEF22  RASGRP42  RAPGEF62  RASGRP12  RASGEF1A2  RAPGEF42  RASGEF1C2  
    RAPGEF52  RASGEF1B2  RASGRP22  RASGRP32  
    12 SIMAP similar genes for RAPGEF3 using alignment to 8 protein entries:     RPGF3_HUMAN (see all proteins):
    DKFZp781H1715    RAPGEF4    Nbla00496    RAPGEFL1    CGEF2    RAPGEF5
    DKFZp586O1422    KIA001LB    PDZGEF1    RAPGEF2    RAPGEF6    FNIP1

    RAPGEF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/776 SNPs in RAPGEF3 are shown (see all 776)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0479254
    ----see VAR_0479252 R G mis40--------
    rs1443732541,2
    --48127953(+) GGTGCA/GCACCA 3 -- int10--------
    rs1883418011,2
    --48127963(+) ACCATA/TCCCGG 3 -- int10--------
    rs1487737031,2
    --48127964(+) CCATAC/TCCGGG 3 -- int10--------
    rs1414977541,2
    --48127965(+) CATACC/TCGGGT 3 -- int10--------
    rs7572841,2
    C,F,A,H--48128119(-) ACGTAC/GTTACT 3 -- int137Minor allele frequency- N:0.00MN NS EA NA WA CSA 3668
    rs1932016701,2
    --48128123(+) AGTACA/GTGAAA 3 -- int10--------
    rs111682131,2
    C,F,H--48128186(+) CTAATC/ACTGCA 3 -- int116Minor allele frequency- A:0.04NS EA NA WA 1640
    rs108756831,2
    C,F,A,H--48128283(+) CTTCAC/GCTGTC 3 -- int127Minor allele frequency- G:0.20NS EA NA WA CSA 2770
    rs1508747631,2
    --48128304(+) TTAAGC/TAGTTA 3 -- int10--------

    HapMap Linkage Disequilibrium report for RAPGEF3 (48128453 - 48164823 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RAPGEF3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv696CNV Insertion18451855
    dgv94n21CNV Loss19592680
    nsv518315CNV Loss19592680
    nsv899059CNV Loss21882294
    nsv470289CNV Gain18288195

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RAPGEF3
    DNA2.0 Custom Variant and Variant Library Synthesis for RAPGEF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606057    OMIM disorders: --

    19 diseases for RAPGEF3:    About MalaCards
    follicular adenoma    nicotine dependence    thrombocytopenia    gingivitis
    acute lymphoblastic leukemia    endotheliitis    alzheimer's disease    chronic obstructive pulmonary disease
    lymphoblastic leukemia    adenoma    melanoma    pancreatitis
    pancreatic cancer    thyroiditis    leukemia    lung cancer
    neuronitis    prostate cancer    prostatitis


    RAPGEF3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for RAPGEF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertrophy 6.72 3 18323524 (1), 19307703 (1), 16269655 (1)
    inflammation 0 2 17068197 (1), 18176800 (1)
    tumors 0 1 18172027 (1)
    alzheimers disease 0 1 16246111 (1)

    Genetic Association Database (GAD): RAPGEF3
    Human Genome Epidemiology (HuGE) Navigator: RAPGEF3 (3 documents)

    Export disorders for RAPGEF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAPGEF3 gene, integrated from 9 sources (see all 200):
    (articles sorted by number of sources associating them with RAPGEF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. (PubMed id 10777494)1, 2, 3 de Rooij J....Bos J.L. (2000)
    2. A family of cAMP-binding proteins that directly activate rap1. (PubMed id 9856955)1, 2, 3 Kawasaki H.... Graybiel A.M. (1998)
    3. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. (PubMed id 9853756)1, 2, 9 de Rooij J.... Bos J.L. (1998)
    4. Association study of the Epac gene and tobacco smoking and nicotine dependence. (PubMed id 15274052)1, 4, 9 Chen X....Kendler K.S. (2004)
    5. A phosphodiesterase 3B-based signaling complex integr ates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase sig nals in human arterial endothelial cells. (PubMed id 21393242)1, 2 Wilson L.S....Maurice D.H. (2011)
    6. An association between Epac-1 gene variants and anxie ty and depression in two independent samples. (PubMed id 19475578)1, 4 Middeldorp C.M....Chen X. (2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Structure and regulation of the cAMP-binding domains of Epac2. (PubMed id 12469113)1, 2 Rehmann H....Wittinghofer A. (2003)
    10. MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion. (PubMed id 15591041)1, 9 Gupta M. and Yarwood S.J. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10411 HGNC: 16629 AceView: RAPGEF3 Ensembl:ENSG00000079337 euGenes: HUgn10411
    ECgene: RAPGEF3 Kegg: 10411 H-InvDB: RAPGEF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAPGEF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAPGEF3 gene:
    Search GeneIP for patents involving RAPGEF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RAPGEF3   OriGene RNAi products in human, mouse, rat for RAPGEF3  
     OriGene qPCR primer pairs and template standards for RAPGEF3   OriGene Protein Over-expression Lysate for RAPGEF3  
     OriGene MassSpec something-or-other for RAPGEF3   OriGene clones in human, mouse for RAPGEF3  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAPGEF3   OriGene Purified Protein for RAPGEF3  
     OriGene ORF clones in mouse, rat for RAPGEF3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAPGEF3   OriGene Custom Protein Services for RAPGEF3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAPGEF3
     QIAGEN SeqTarget long-range PCR primers for resequencing RAPGEF3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAPGEF3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAPGEF3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEF3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAPGEF3
     GenScript Custom Purified and Recombinant Proteins Services for RAPGEF3 GenScript cDNA clones with any tag delivered in your preferred vector for RAPGEF3
     GenScript Custom Assay Services for RAPGEF3 GenScript Custom Superior Antibodies Services for RAPGEF3
     GenScript Custom overexpressing Cell Line Services for RAPGEF3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for RAPGEF3  (Epac1)

     Regulatory tfbs in RAPGEF3 promoter
     Search Chromatin IP Primers for RAPGEF3
     RT2 qPCR Primer Assay in human, mouse, rat RAPGEF3
     GNC Network for RAPGEF3
     SABiosciences Custom PCR Arrays for RAPGEF3
     Tocris compounds for RAPGEF3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for RAPGEF3
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RAPGEF3 antibodies
     RAPGEF3 proteins
     RAPGEF3 lysates
     Antibodies for RAPGEF3
     See all of Abcam's Antibodies, Kits and Proteins for RAPGEF3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RAPGEF3
     Antibodies for RAPGEF3
     ELISAs for RAPGEF3
     CLIAs for RAPGEF3
     Search LifeMap BioReagents cell lines for RAPGEF3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF3
     SwitchGear 3'UTR luciferase reporter plasmids for RAPGEF3
     SwitchGear Promoter luciferase reporter plasmids for RAPGEF3
     ThermoFisher Antibodies for RAPGEF3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEF3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RAPGEF3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAPGEF3
    Customized:
     lentivirus for stable overexpression of RAPGEF3
     lentivirus expression plasmids for stable overexpression of RAPGEF3
     adenovirus for overexpression of RAPGEF3
     LSBio Antibodies in human, mouse, rat for RAPGEF3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAPGEF3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4