RAPGEF1 Gene
protein-coding GIFtS: 61
GCID: GC09M134452
|
|
Rap guanine nucleotide exchange factor (GEF) 1(Previous name: guanine nucleotide-releasing factor 2 (specific for crk...)
(Previous symbol: GRF2)
| |
Aliases
for RAPGEF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rap Guanine Nucleotide Exchange Factor (GEF) 11 2 | | CRK SH3-Binding GNRP2 3 | | GRF21 2 3 5 | | Rap Guanine Nucleotide Exchange Factor 12 | | C3G1 2 5 | | Guanine Nucleotide-Releasing Factor 23 | | Guanine Nucleotide-Releasing Factor 2 (Specific For Crk Proto-Oncogene)1 2 | | Protein C3G3 |
Export aliases for RAPGEF1 gene to outside databasesPrevious GC identifers: GC09M129729 GC09M131481 GC09M133441 GC09M103946 |
Summaries
for RAPGEF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAPGEF1:
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domainof CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved inapoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcriptvariants of this gene have been described, but the full-length nature of some variants has not been determined.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RPGF1_HUMAN, Q13905Function: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals fromCRK to activate RAS
Gene Wiki entry for RAPGEF1
|
Genomic Views
for RAPGEF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_035014.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAPGEF1 gene promoter:
AP-1 ATF-2 c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAPGEF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAPGEF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.13 HGNC cytogenetic band: 9q34.3RAPGEF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M134452: view genomic region
(about GC identifiers)
Start:
|
134,452,157 bp from pter |
End:
|
134,615,461 bp from pter |
Size:
|
163,305 bases |
Orientation:
|
minus strand |
|
Proteins
for RAPGEF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RPGF1_HUMAN, Q13905 (See
protein sequence)Recommended Name: Rap guanine nucleotide exchange factor 1 Size: 1077 amino acids; 120548 Da
Subunit: Interacts with CRK via its SH3-binding sites
Secondary accessions: Q5JUE4 Q8IV73Alternative splicing: 3 isoforms: Q13905-1 Q13905-2 Q13905-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RAPGEF1: NX_Q13905
Post-translational modifications:
Phosphorylation at Tyr-504 enhances activity as Rap guanine nucleotide exchange factor1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13905
RAPGEF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_005303.2 NP_941372.1
ENSEMBL proteins: ENSP00000266110 ENSP00000361269 ENSP00000405967 ENSP00000407210 ENSP00000394296 ENSP00000410640 ENSP00000402174 ENSP00000350315 ENSP00000361263 ENSP00000361264 Reactome Protein details: Q13905
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RAPGEF1 for ontologies About GeneDecksing
RAPGEF1 Antibody Products:
Assay Products for RAPGEF1: |
Protein
Domains /
Families
for RAPGEF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAPGEF1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13905ProtoNet protein and cluster: Q13905 1 Blocks protein family: IPB001895 Guanine-nucleotide dissociation stimulator CDC25
UniProtKB/Swiss-Prot: RPGF1_HUMAN, Q13905Similarity: Contains 1 N-terminal Ras-GEF domainSimilarity: Contains 1 Ras-GEF domain |
Function
for RAPGEF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RPGF1_HUMAN, Q13905Function: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals fromCRK to activate RAS
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEF1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RAPGEF1 (NM_005312) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAPGEF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RAPGEF1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RAPGEF1:
Animal Models:
Mouse knock-out Rapgef1tm1Mats for RAPGEF1
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Rapgef1):
RAPGEF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAPGEF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/35 super-pathways (see all 35) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development HGF signaling pathway | | | 2 | G-protein signaling Rap1A regulation pathway | | | 3 | Focal Adhesion | | | 4 | Signaling by FGFR | | | 5 | Immune response_IFN gamma signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 EMD Millipore Pathways for RAPGEF1 (see all 9)
1  R&D Systems Pathway for RAPGEF1
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAPGEF1 (see all 6)
5/9  GeneGo (Thomson Reuters) Pathways for RAPGEF1 (see all 9)
5/17  BioSystems Pathways for RAPGEF1 (see all 17)
5/13 
Reactome Pathways for RAPGEF1 (see all 13)
4 
Kegg Pathways (Kegg details for RAPGEF1):
RAPGEF1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAPGEF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/38 Interacting proteins for RAPGEF1 (Q139051, 2, 3 ENSP000003612644) via UniProtKB, MINT, STRING, and/or I2D (see all 38)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CRK | P461081, 2, 3, ENSP000003005744 | EBI-976876,EBI-886 MINT-15982 I2D:
score=7 STRING: ENSP00000300574 | | PIK3R1 | P279861, 2, 3, ENSP000002743354 | EBI-976876,EBI-79464 MINT-8112195 I2D:
score=3 STRING: ENSP00000274335 | | ABL1 | P005192, 3, ENSP000003614234 | MINT-8110719 MINT-7213240 MINT-7213283 MINT-7213267 I2D:
score=3 STRING: ENSP00000361423 | | CRKL | P461092, 3, ENSP000003463004 | MINT-7213231 MINT-7213262 I2D:
score=4 STRING: ENSP00000346300 | | FYN | P062411, 3, ENSP000003576564 | EBI-976876,EBI-2561531 I2D:
score=2 STRING: ENSP00000357656 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
RAPGEF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RAPGEF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAPGEF1
Search CenterWatch for drugs/clinical trials and news about RAPGEF1 / RPGF1
|
Transcripts
for RAPGEF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAPGEF1 gene (2 alternative transcripts): NM_005312.2 NM_198679.1 Unigene Cluster for RAPGEF1: Rap guanine nucleotide exchange factor (GEF) 1 Hs.127897 [show with all ESTs]Unigene Representative Sequence: NM_19867911 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000266110 ENST00000372195 ENST00000429421(uc010mzl.1 uc010mzo.1 uc010mzp.1 uc010mzm.3)
ENST00000414781 ENST00000419442(uc010mzr.1 uc010mzq.1 uc010mzs.1)
ENST00000481260 ENST00000438647 ENST00000427994 ENST00000357686(uc022bou.1 uc022bov.1)
ENST00000372189(uc022bot.1) ENST00000372190(uc022bos.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEF1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RAPGEF1 (NM_005312) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAPGEF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEF1 |
Additional cDNA sequence: AJ420417.1 AK302763.1 BC041710.1 CR749354.1 D21239.1 DQ925677.1 DQ925678.1 DQ925679.1 DQ925680.1 DQ925681.1 DQ925682.1 DQ925683.1 DQ925684.1 21 DOTS entries: DT.92431967 DT.316981 DT.100779638 DT.40122665 DT.100779639 DT.75183099 DT.86851760 DT.92431968 DT.40315725 DT.95347072 DT.100738450 DT.100776031 DT.121160998 DT.92060025 DT.92431972 DT.95270527 DT.97781075 DT.101954250 DT.407004 DT.426595 DT.92004610 24/320 AceView cDNA sequences (see all 320): BE396488 BM917164 BG983342 BQ054243 BM914033 BQ221036 BM704309 BX097548 BM701260 AA300930 BX328263 BG236282 BM917860 W57969 BQ070501 BE018171 AW504921 BG696331 BQ708232 BU431048 BM725619 AW500020 T11437 CR749354
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RAPGEF1 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · |
|---|
|
| SP1: | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | |
| SP2: | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20b | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RAPGEF1
|
Expression
for RAPGEF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAPGEF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RAPGEF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAPGEF1
SOURCE GeneReport for Unigene cluster: Hs.127897
UniProtKB/Swiss-Prot: RPGF1_HUMAN, Q13905Tissue specificity: Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placentaand in fetal brain and heart. Low levels of expression in adult and fetal liver
SABiosciences Expression via Pathway-Focused PCR Arrays including RAPGEF1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAPGEF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAPGEF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAPGEF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF1 |
Orthologs
for RAPGEF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RAPGEF1 gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RAPGEF11 |
Rap guanine nucleotide exchange factor (GEF) 1 |
80.2(n)
87.56(a) |
|
417173 XM_415456.3 XP_415456.3 |
lizard
(Anolis carolinensis) |
Reptilia |
RAPGEF16 |
-- |
63(a) |
1 ↔ 1 |
GL344551.1(4342-15944) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ039810.12 |
-- |
82.34(n) |
|
BJ039810.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc563722 |
similar to guanine nucleotide-releasing factor 2 (specific more |
75.24(n) |
|
394101 BC049305.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
C3G1 |
C3G |
50.23(n)
42.02(a) |
|
31618 NM_001144694.2 NP_001138166.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y34B4A.46 |
Protein Y34B4A.4, isoform b |
28(a) |
1 ↔ 1 |
X(5264298-5271774) |
ENSEMBL Gene Tree for RAPGEF1 (if available)
TreeFam Gene Tree for RAPGEF1 (if available) |
Paralogs
for RAPGEF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAPGEF1 gene
- RALGPS22 RASGRF12 RGL22 SOS22 RASGRF22 SOS12 RGL32 RALGDS2
- RALGPS12 RGL12 RGL42
2 SIMAP similar genes for RAPGEF1 using alignment to 14 protein entries: RPGF1_HUMAN (see all proteins):DKFZp781P1719 DKFZp781H1715
RAPGEF1 for paralogs About GeneDecksing
|
Genomic Variants
for RAPGEF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAPGEF1 (134452157 - 134615461 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RAPGEF1
1 CNV: 2839 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAPGEF1 |
|
Disorders
/ Diseases
for RAPGEF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAPGEF1 for disorders About GeneDecksing
OMIM gene information: 600303
OMIM disorders: --
18  diseases for RAPGEF1: About MalaCardscervical squamous cell carcinoma squamous cell carcinoma papillary thyroid carcinoma blastoma
renal cell carcinoma cblc bipolar disorder thyroid carcinoma
carcinoma thyroiditis cervicitis breast carcinoma
lung cancer cholesterol neuroblastoma melanoma
leukemia acute promyelocytic leukemia
Human Genome Epidemiology (HuGE) Navigator: RAPGEF1 (8 documents)
Export disorders for RAPGEF1 gene to outside databases
|
Publications
for RAPGEF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAPGEF1 gene, integrated from 9 sources (see all 77):
(articles sorted by number of sources associating them with RAPGEF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. (PubMed id 7512734)1, 2, 3 Tanaka S....Matsuda M. (1994)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain. (PubMed id 14551197)1, 2 Shivakrupa R....Swarup G. (2003)
- Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. (PubMed id 8662907)1, 2 Matsuda M.... Kurata T. (1996)
- Mapping of the human C3G gene coding a guanine nucleotide releasing protein for Ras family to 9q34.3 by fluorescence in situ hybridization. (PubMed id 7959692)1, 3 Takai S....Matsuda M. (1994)
- Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk. (PubMed id 7806500)1, 2 Knudsen B.... Hanafusa H. (1994)
- RAPGEF1 gene variants associated with type 2 diabetes in the Korean population. (PubMed id 19297053)1, 9 Hong K.W....Oh B. (2009)
- Expression of the Rap1 guanine nucleotide exchange fa ctor, MR-GEF, is altered in individuals with bipolar disorder. (PubMed id 20436929)1, 9 Bithell A....Williams B.P. (2010)
- Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton. (PubMed id 15320955)1, 9 Radha V....Swarup G. (2004)
- C3G transgenic mouse models with specific expression i n platelets reveal a new role for C3G in platelet clotting through its GEF activ ity. (PubMed id 22659131)1 Gutierrez-Herrero S....Guerrero C. (2012)
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External Searches for RAPGEF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RAPGEF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RAPGEF1 gene
(According to HUGE)
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Specialized Databases showing RAPGEF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for RAPGEF1 gene:
Search GeneIP for patents involving RAPGEF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RAPGEF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RAPGEF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAPGEF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAPGEF1 | | | OriGene Protein Over-expression Lysate for RAPGEF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAPGEF1 | | OriGene 3'-UTR Clone for RAPGEF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAPGEF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAPGEF1 | | OriGene Custom Protein Services for RAPGEF1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAPGEF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAPGEF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAPGEF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAPGEF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAPGEF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAPGEF1 |
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| | | | Search Tocris compounds for RAPGEF1 |
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 | | | RAPGEF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAPGEF1 |
|  |  |  | | | | Search ThermoFisher Antibodies for RAPGEF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAPGEF1 |
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