Aliases for RAPGEF1 Gene
External Ids for RAPGEF1 Gene
Previous HGNC Symbols for RAPGEF1 Gene
Previous GeneCards Identifiers for RAPGEF1 Gene
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for RAPGEF1 Gene
RAPGEF1 (Rap Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and RET signaling. GO annotations related to this gene include SH3 domain binding and Rap guanyl-nucleotide exchange factor activity. An important paralog of this gene is SOS2.
UniProtKB/Swiss-Prot for RAPGEF1 Gene
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.