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Aliases for RAP2C Gene

Aliases for RAP2C Gene

  • RAP2C, Member Of RAS Oncogene Family 2 3 5

External Ids for RAP2C Gene

Previous GeneCards Identifiers for RAP2C Gene

  • GC0XM129282
  • GC0XM130042
  • GC0XM131062
  • GC0XM131164
  • GC0XM131337
  • GC0XM120741

Summaries for RAP2C Gene

Entrez Gene Summary for RAP2C Gene

  • The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

GeneCards Summary for RAP2C Gene

RAP2C (RAP2C, Member Of RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are ERK Signaling. GO annotations related to this gene include GTP binding and transcription coactivator activity. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for RAP2C Gene

  • Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP2C Gene

Genomics for RAP2C Gene

Regulatory Elements for RAP2C Gene

Enhancers for RAP2C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAP2C on UCSC Golden Path with GeneCards custom track

Genomic Location for RAP2C Gene

Chromosome:
X
Start:
132,203,024 bp from pter
End:
132,219,480 bp from pter
Size:
16,457 bases
Orientation:
Minus strand

Genomic View for RAP2C Gene

Genes around RAP2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAP2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAP2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP2C Gene

Proteins for RAP2C Gene

  • Protein details for RAP2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3L5-RAP2C_HUMAN
    Recommended name:
    Ras-related protein Rap-2c
    Protein Accession:
    Q9Y3L5
    Secondary Accessions:
    • B3KWD6
    • Q5H9H9
    • Q9BTS0

    Protein attributes for RAP2C Gene

    Size:
    183 amino acids
    Molecular mass:
    20745 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAP2C Gene

Proteomics data for RAP2C Gene at MOPED

Post-translational modifications for RAP2C Gene

  • Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
  • Ubiquitination at Lys 108
  • Modification sites at PhosphoSitePlus

Other Protein References for RAP2C Gene

No data available for DME Specific Peptides for RAP2C Gene

Domains & Families for RAP2C Gene

Gene Families for RAP2C Gene

Suggested Antigen Peptide Sequences for RAP2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3L5

UniProtKB/Swiss-Prot:

RAP2C_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RAP2C: view

Function for RAP2C Gene

Molecular function for RAP2C Gene

UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.
genes like me logo Genes that share phenotypes with RAP2C: view

Animal Model Products

miRNA for RAP2C Gene

miRTarBase miRNAs that target RAP2C

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAP2C Gene

Localization for RAP2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP2C Gene

Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAP2C Gene COMPARTMENTS Subcellular localization image for RAP2C gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
cytosol 4
mitochondrion 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044291 cell-cell contact zone IDA 23885123
GO:0055038 recycling endosome membrane ISS --
genes like me logo Genes that share ontologies with RAP2C: view

Pathways & Interactions for RAP2C Gene

SuperPathways for RAP2C Gene

Superpath Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with RAP2C: view

Pathways by source for RAP2C Gene

1 Qiagen pathway for RAP2C Gene

Gene Ontology (GO) - Biological Process for RAP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0031954 positive regulation of protein autophosphorylation ISS --
GO:0090557 establishment of endothelial intestinal barrier IMP 23885123
genes like me logo Genes that share ontologies with RAP2C: view

No data available for SIGNOR curated interactions for RAP2C Gene

Drugs & Compounds for RAP2C Gene

No Compound Related Data Available

Transcripts for RAP2C Gene

Unigene Clusters for RAP2C Gene

RAP2C, member of RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAP2C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for RAP2C Gene

GeneLoc Exon Structure for
RAP2C
ECgene alternative splicing isoforms for
RAP2C

Expression for RAP2C Gene

mRNA expression in normal human tissues for RAP2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAP2C Gene

This gene is overexpressed in Uterus (x6.2).

Protein differential expression in normal tissues from HIPED for RAP2C Gene

This gene is overexpressed in Brain (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAP2C Gene



SOURCE GeneReport for Unigene cluster for RAP2C Gene Hs.119889

mRNA Expression by UniProt/SwissProt for RAP2C Gene

Q9Y3L5-RAP2C_HUMAN
Tissue specificity: Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.
genes like me logo Genes that share expression patterns with RAP2C: view

Protein tissue co-expression partners for RAP2C Gene

Primer Products

Orthologs for RAP2C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAP2C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAP2C 35
  • 97.63 (n)
  • 100 (a)
RAP2C 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAP2C 35
  • 97.45 (n)
  • 100 (a)
RAP2C 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rap2c 35
  • 94.9 (n)
  • 100 (a)
Rap2c 16
Rap2c 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rap2c 35
  • 95.45 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RAP2C 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAP2C 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAP2C 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rap2c 35
  • 80.69 (n)
  • 96.72 (a)
Str.3585 35
African clawed frog
(Xenopus laevis)
Amphibia rap2c-prov 35
zebrafish
(Danio rerio)
Actinopterygii rap2c 35
  • 76.32 (n)
  • 92.9 (a)
rap2c 36
  • 93 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Rap2l 36
  • 69 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rap-2 36
  • 70 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4500 35
Species with no ortholog for RAP2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP2C Gene

ENSEMBL:
Gene Tree for RAP2C (if available)
TreeFam:
Gene Tree for RAP2C (if available)

Paralogs for RAP2C Gene

Pseudogenes.org Pseudogenes for RAP2C Gene

genes like me logo Genes that share paralogs with RAP2C: view

Variants for RAP2C Gene

Sequence variations from dbSNP and Humsavar for RAP2C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747812242 -- 132,216,008(+) TTAAG(A/G)TCTCT intron-variant
rs748035767 -- 132,211,641(+) CGAGG(C/G)CTGTG intron-variant
rs748072039 -- 132,209,860(+) CACTC(C/T)CAAGT intron-variant
rs748154670 -- 132,211,820(+) TTAGC(A/G)ACAAA intron-variant
rs748348146 -- 132,214,149(+) TGGCC(A/G)TGATT nc-transcript-variant, utr-variant-3-prime

Variation tolerance for RAP2C Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RAP2C Gene

Disorders for RAP2C Gene

Relevant External Links for RAP2C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAP2C

No disorders were found for RAP2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAP2C Gene

Publications for RAP2C Gene

  1. Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. (PMID: 17447155) Guo Z. … Yu L. (Mol. Biol. Rep. 2007) 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human I^a88-adrenergic receptor. (PMID: 24561123) Kittanakom S. … Stagljar I. (Biochem. Biophys. Res. Commun. 2014) 3
  5. JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function. (PMID: 23885123) Monteiro A.C. … Parkos C.A. (Mol. Biol. Cell 2013) 3

Products for RAP2C Gene

Sources for RAP2C Gene

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