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RAP2C Gene

protein-coding   GIFtS: 52
GCID: GC0XM131337

RAP2C, Member Of RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RAP2C, Member Of RAS Oncogene Family1 2
Ras-Related Protein Rap-2c2
Small GTPase RAP2C2

External Ids:    HGNC: 211651   Entrez Gene: 578262   Ensembl: ENSG000001237287   UniProtKB: Q9Y3L53   
ORGUL members:         

Export aliases for RAP2C gene to outside databases

Previous GC identifers: GC0XM129282 GC0XM130042 GC0XM131062 GC0XM131164 GC0XM120741


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAP2C Gene:
The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily.
Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation,
differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of
the serum response element. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Sep 2012)

GeneCards Summary for RAP2C Gene:
RAP2C (RAP2C, member of RAS oncogene family) is a protein-coding gene. Diseases associated with RAP2C include vesiculitis, and lymphoblastic leukemia. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL10B.

UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5
Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May
play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK.
May play a role in SRE-mediated gene transcription




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAP2C gene promoter:
         Nkx3-1   Nkx3-1 v1   POU3F2   c-Ets-1   Nkx3-1 v2   CREB   E2F   E2F-1   HOXA5   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAP2C promoter sequence
   Search Chromatin IP Primers for RAP2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAP2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25   Ensembl cytogenetic band:  Xq26.2   HGNC cytogenetic band: Xq25

RAP2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP2C gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM131337:  view genomic region     (about GC identifiers)

Start:
131,337,053 bp from pter      End:
131,353,471 bp from pter
Size:
16,419 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5 (See protein sequence)
Recommended Name: Ras-related protein Rap-2c precursor  
Size: 183 amino acids; 20745 Da
Secondary accessions: B3KWD6 Q5H9H9 Q9BTS0

Explore the universe of human proteins at neXtProt for RAP2C: NX_Q9Y3L5

Explore proteomics data for RAP2C at MOPED

Post-translational modifications: 

  • Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK
    (By similarity)1
  • Ubiquitination2 at Lys5, Lys108
  • Modification sites at PhosphoSitePlus

  • See RAP2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258115.1  NP_001258116.1  NP_067006.3  

    ENSEMBL proteins: 
     ENSP00000340274   ENSP00000359911  

    RAP2C Human Recombinant Protein Products:

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    Novus Biologicals RAP2C Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for RAP2C

    RAP2C Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q9Y3L5

    ProtoNet protein and cluster: Q9Y3L5

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RAP2C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAP2C_HUMAN, Q9Y3L5
    Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May
    play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK.
    May play a role in SRE-mediated gene transcription

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA17447155
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IDA16213650
    GO:0019003GDP binding IDA16213650
         
    RAP2C for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RAP2C:
     Big cells  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAP2C
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAP2C

    miRNA
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    miRTarBase miRNAs that target RAP2C:
    hsa-mir-375 (MIRT019855), hsa-mir-33a-5p (MIRT028204), hsa-mir-19b-3p (MIRT031209), hsa-mir-423-3p (MIRT016688), hsa-mir-130b-3p (MIRT020214), hsa-mir-26b-5p (MIRT029388), hsa-let-7b-5p (MIRT032253), hsa-mir-100-5p (MIRT048458), hsa-mir-24-3p (MIRT030453), hsa-mir-454-3p (MIRT039229)

    Block miRNA regulation of human, mouse, rat RAP2C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAP2C (see all 105):
    hsa-miR-3678-3p hsa-miR-607 hsa-miR-188-5p hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-30d hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidRAP2C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAP2C

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: RAP2C (NM_021183)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP2C

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAP2C_HUMAN, Q9Y3L5: Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    mitochondrion2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA17447155
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IDA16213650
    GO:0016020membrane ----

    RAP2C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAP2C About    
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Molecular Mechanisms of Cancer0.51

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAP2C
        Molecular Mechanisms of Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAP2C
    Interactions:

        Search GeneGlobe Interaction Network for RAP2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for RAP2C (Q9Y3L53 ENSP000003402744) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    CSNK1EP496743I2D: score=1 
    CTNNB1P352223I2D: score=1 
    DVL2O146413I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IEA--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----
    GO:0015031protein transport ----
    GO:0030336negative regulation of cell migration ISS--

    RAP2C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAP2C



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RAP2C gene (3 alternative transcripts): 
    NM_001271186.1  NM_001271187.1  NM_021183.4  

    Unigene Cluster for RAP2C:

    RAP2C, member of RAS oncogene family
    Hs.119889  [show with all ESTs]
    Unigene Representative Sequence: NM_001271186
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342983(uc004ewo.3 uc004ewp.3 uc010nrk.3 uc004ewq.4)
    ENST00000370874 ENST00000460462 ENST00000490400
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RAP2C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAP2C (see all 105):
    hsa-miR-3678-3p hsa-miR-607 hsa-miR-188-5p hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-30d hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidRAP2C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RAP2C
    Predesigned siRNA for gene silencing in human, mouse, rat RAP2C
    Clone
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    GenScript: all cDNA clones in your preferred vector: RAP2C (NM_021183)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP2C
    Primer
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    OriGene qPCR primer pairs and template standards for RAP2C
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RAP2C
      QuantiTect SYBR Green Assays in human, mouse, rat RAP2C
      QuantiFast Probe-based Assays in human, mouse, rat RAP2C

    Additional mRNA sequence: 

    AF093744.1 AK124801.1 AL049685.2 AL832461.1 AY298955.1 BC003403.1 BC035382.1 BC051467.1 
    BX647223.1 NR_073150.1 

    7 DOTS entries:

    DT.111337  DT.97812656  DT.95080840  DT.91852181  DT.75132773  DT.92429142  DT.99996497 

    Selected AceView cDNA sequences (see all 131):

    AW089784 AA588562 BG613592 BE856717 BM126916 AK124801 BU159641 BC035382 
    AA635752 AL049685 AA995170 BX647223 C01578 AA046625 CD678940 BE327676 
    NM_021183 AI934005 AW978491 BM450598 AY298955 BF515127 CD678323 CK818730 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAP2C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:              -     -           -     -     -     -     -                                       
    SP2:              -     -                 -                                                         
    SP3:                                -     -                                                         
    SP4:                                                                          -                     
    SP5:                                                                          -                     


    ECgene alternative splicing isoforms for RAP2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAP2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTAATGT
    RAP2C Expression
    About this image


    RAP2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Uterus (Reproductive System)
    RAP2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAP2C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.119889

    UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5
    Tissue specificity: Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a
    lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes

        Custom PCR Arrays for RAP2C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAP2C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap2c1 , 5 RAP2C, member of RAS oncogene family1, 5 94.9(n)1
    100(a)1
      X (28.03 cM)5
    720651  NM_172413.21  NP_766001.11 
     510039125 
    African clawed frog
    (Xenopus laevis)
    Amphibia rap2c-prov2 RAP2C, member of RAS oncogene family 81.37(n)    BC043998.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rap2c1 RAP2C, member of RAS oncogene family 76.32(n)
    92.9(a)
      474323  NM_001007055.1  NP_001007056.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rap2l6
    Ras-associated protein 2-like
    69(a)
    1 → many
    2R(19950576-19952928)
    worm
    (Caenorhabditis elegans)
    Secernentea rap-26
    Protein RAP-2 (rap-2) mRNA, complete cds
    70(a)
    1 → many
    V(15061263-15064087) WBGene00004308
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSR16
    GTP-binding protein of the ras superfamily require...
    35(a)
    1 → many
    VII(794674-795492) YGR152C


    ENSEMBL Gene Tree for RAP2C (if available)
    TreeFam Gene Tree for RAP2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAP2C gene
    RASL10B2  DIRAS12  RAP1B2  RASD22  RIT22  RAP2A2  RIT12  RAP1A2  
    RAP2B2  RASD12  DIRAS22  RASL10A2  DIRAS32  
    Selected SIMAP similar genes for RAP2C using alignment to 1 protein entry:     RAP2C_HUMAN(see all similar genes):
    RAP2A    DKFZp547A0616    RAP2B    RAP1B    c-bas/has    RAP1A
    RIT2    RIT1    DIRAS2    RALA    DIRAS1    RALB
    KRAS    MRAS    NRAS    HRAS    RERG    RRAS2

    RAP2C for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RAP2C
    PGOHUM00000248275 PGOHUM00000248277


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAP2C (see all 212)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864818511,2
    --131311174(+) AAAAAA/GATGGC 1 -- int10--------
    rs1828482891,2
    --131336827(+) TTTCTA/GTAATA 4 -- ds50010--------
    rs1472418341,2
    --131336901(+) GGAAAC/TAGGCG 4 -- ds50010--------
    rs1874800681,2
    --131336965(+) ATAAAA/CAGTAA 4 -- ds50010--------
    rs1931869361,2
    --131337005(+) GTTAGC/TAAATC 4 -- ds50010--------
    rs1854569531,2
    --131337391(+) TTGAGA/GAAGCT 4 -- ut31 nc-transcript-variant0--------
    rs1891320491,2
    --131337414(+) GGTCCC/TTTTTC 4 -- ut31 nc-transcript-variant0--------
    rs1921898451,2
    --131337443(+) ACCACA/CTTTAA 4 -- ut31 nc-transcript-variant0--------
    rs1836474741,2
    --131337611(+) TACAGA/GAAAGA 4 -- ut31 nc-transcript-variant0--------
    rs1883563441,2
    --131337954(+) TAGTCA/CATTTC 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for RAP2C (131337053 - 131353471 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RAP2C: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAP2C
    DNA2.0 Custom Variant and Variant Library Synthesis for RAP2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for RAP2C:    
    About MalaCards
    vesiculitis    lymphoblastic leukemia    mental retardation    leukemia
    prostatitis


    RAP2C for disorders           About GeneDecksing


    Export disorders for RAP2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAP2C gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with RAP2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. (PubMed id 17447155)1, 2 Guo Z....Yu L. (Mol. Biol. Rep. 2007)
    2. Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins. (PubMed id 16213650)1, 2 Paganini S.... Torti M. (Biochimie 2006)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis. (PubMed id 21668950)1 Lombard Z....Ramsay M. (Biol. Direct 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57826 HGNC: 21165 AceView: RAP2C Ensembl:ENSG00000123728 euGenes: HUgn57826
    ECgene: RAP2C H-InvDB: RAP2C

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RAP2C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP2C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RAP2C gene:
    Search GeneIP for patents involving RAP2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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