RAP2C Gene
protein-coding GIFtS: 49
GCID: GC0XM131337
|
|
RAP2C, member of RAS oncogene family
| |
Aliases
for RAP2C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAP2C, Member Of RAS Oncogene Family1 2 | | DKFZp313B2111 | | Ras-Related Protein Rap-2c2 | | Small GTPase RAP2C2 |
Export aliases for RAP2C gene to outside databasesPrevious GC identifers: GC0XM129282 GC0XM130042 GC0XM131062 GC0XM131164 GC0XM120741 |
Summaries
for RAP2C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAP2C:
The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily.Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation,differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of theserum response element. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2012)
UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play arole in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play arole in SRE-mediated gene transcription
|
Genomic Views
for RAP2C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAP2C gene promoter:
Nkx3-1 Nkx3-1 v1 POU3F2 c-Ets-1 Nkx3-1 v2 CREB E2F E2F-1 HOXA5 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAP2C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP2C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq25 Ensembl cytogenetic band: Xq26.2 HGNC cytogenetic band: Xq25RAP2C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM131337: view genomic region
(about GC identifiers)
Start:
|
131,337,053 bp from pter |
End:
|
131,353,471 bp from pter |
Size:
|
16,419 bases |
Orientation:
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minus strand |
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Proteins
for RAP2C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5 (See
protein sequence)Recommended Name: Ras-related protein Rap-2c precursor Size: 183 amino acids; 20745 Da
Subcellular location: Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity)
Secondary accessions: B3KWD6 Q5H9H9 Q9BTS0Explore the universe of human proteins at neXtProt for RAP2C: NX_Q9Y3L5
Post-translational modifications:
Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK (Bysimilarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3L5
RAP2C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001258115.1 NP_001258116.1 NP_067006.3
ENSEMBL proteins: ENSP00000340274 ENSP00000359911
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RAP2C for ontologies About GeneDecksing
RAP2C Antibody Products:
Assay Products for RAP2C: |
Protein
Domains /
Families
for RAP2C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAP2C for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y3L5ProtoNet protein and cluster: Q9Y3L5 2 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB003577 Ras small GTPase
UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5Similarity: Belongs to the small GTPase superfamily. Ras family |
Function
for RAP2C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play arole in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play arole in SRE-mediated gene transcription
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAP2C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2C |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RAP2C for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RAP2C:
|
Pathways & Interactions
for RAP2C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Rho Family GTPases | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAP2C
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAP2C
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/9 Interacting proteins for RAP2C (Q9Y3L53 ENSP000003402744) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030336 | negative regulation of cell migration |
ISS | -- | | GO:0031954 | positive regulation of protein autophosphorylation |
ISS | -- | | GO:0032486 | Rap protein signal transduction |
ISS | -- | | GO:0061097 | regulation of protein tyrosine kinase activity |
ISS | -- |
RAP2C for ontologies About GeneDecksing
|
Drugs & Compounds
for RAP2C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAP2C
Search CenterWatch for drugs/clinical trials and news about RAP2C
|
Transcripts
for RAP2C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAP2C gene (3 alternative transcripts): NM_001271186.1 NM_001271187.1 NM_021183.4 Unigene Cluster for RAP2C: RAP2C, member of RAS oncogene family Hs.119889 [show with all ESTs]Unigene Representative Sequence: NM_0012711864 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000342983(uc004ewo.3 uc004ewp.3 uc010nrk.3 uc004ewq.4)
ENST00000370874 ENST00000460462 ENST00000490400
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAP2C (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAP2C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAP2C (NM_021183) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAP2C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP2C |
Additional cDNA sequence: AF093744.1 AK124801.1 AL049685.2 AL832461.1 AY298955.1 BC003403.1 BC035382.1 BC051467.1 BX647223.1 NR_073150.1 7 DOTS entries: DT.111337 DT.97812656 DT.95080840 DT.91852181 DT.75132773 DT.92429142 DT.99996497 24/131 AceView cDNA sequences (see all 131): AY298955 AI934005 BE327676 BU159641 BF515127 BC035382 NM_021183 BX647223 AA995170 BG613592 AA046625 AW978491 BM450598 AK124801 AA588562 AW089784 CD678323 AL049685 BM126916 BE856717 CD678940 C01578 AA635752 AI828176
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RAP2C About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 |
|---|
|
| SP1: | | | | | - | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for RAP2C
|
Expression
for RAP2C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAP2C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCTAATGT
About this image
See RAP2C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAP2C
SOURCE GeneReport for Unigene cluster: Hs.119889
UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5Tissue specificity: Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lowerextent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes
SABiosciences Custom PCR Arrays for RAP2C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAP2C
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2C |
Orthologs
for RAP2C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RAP2C gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RAP2C6 |
RAP2C, member of RAS oncogene family |
90(a) |
1 ↔ 1 |
4(3465682-3475173) |
African clawed frog
(Xenopus laevis) |
Amphibia |
rap2c-prov2 |
RAP2C, member of RAS oncogene family |
81.37(n) |
|
BC043998.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rap2c1 |
RAP2C, member of RAS oncogene family |
76.32(n)
92.9(a) |
|
474323 NM_001007055.1 NP_001007056.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rap2l6 |
Ras-associated protein 2-like |
69(a) |
1 → many |
2R(19950576-19952928) |
worm
(Caenorhabditis elegans) |
Secernentea |
rap-26rap-36 |
RAP homolog (vertebrate Rap GTPase family) family ...RAP homolog (vertebrate Rap GTPase family) family ... |
70(a)41(a) |
1 ↔ manypossible ortholog |
V(15061246-15064070) IV(11177265-11178057) |
ENSEMBL Gene Tree for RAP2C (if available)
TreeFam Gene Tree for RAP2C (if available) |
Paralogs
for RAP2C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAP2C gene
- RASL10B2 DIRAS12 RAP1B2 RASD22 RAP2A2 RAP1A2 RAP2B2 RASD12
- DIRAS22 RASL10A2 DIRAS32
18/98 SIMAP similar genes for RAP2C using alignment to 1 protein entry: RAP2C_HUMAN(see all similar genes):RAP2A DKFZp547A0616 RAP2B RAP1B c-bas/has RAP1A
RIT2 RIT1 DIRAS2 RALA DIRAS1 RALB
KRAS MRAS NRAS HRAS RERG RRAS2
RAP2C for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RAP2C
PGOHUM00000248275 PGOHUM00000248277
|
Genomic Variants
for RAP2C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAP2C (131337053 - 131353471 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAP2C: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAP2C |
|
Disorders
/ Diseases
for RAP2C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAP2C for disorders About GeneDecksing
5  diseases for RAP2C: About MalaCardsprostatitis acute lymphoblastic leukemia vesiculitis lymphoblastic leukemia
leukemia
Export disorders for RAP2C gene to outside databases
|
Publications
for RAP2C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAP2C gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with RAP2C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. (PubMed id 17447155)1, 2 Guo Z....Yu L. (2007)
- Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins. (PubMed id 16213650)1, 2 Paganini S.... Torti M. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A computational approach to candidate gene prioritiza tion for X-linked mental retardation using annotation-based binary filtering an d motif-based linear discriminatory analysis. (PubMed id 21668950)1 Lombard Z....Ramsay M. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A novel approach to tag and identify geranylgeranylate d proteins. (PubMed id 19784953)1 Chan L.N....Tamanoi F. (2009)
|
External Searches for RAP2C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAP2C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAP2C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAP2C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAP2C gene:
Search GeneIP for patents involving RAP2C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAP2C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2C |
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