Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAP2C Gene

protein-coding   GIFtS: 49
GCID: GC0XM131337

RAP2C, Member Of RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAP2C, Member Of RAS Oncogene Family1 2
Ras-Related Protein Rap-2c2
Small GTPase RAP2C2

External Ids:    HGNC: 211651   Entrez Gene: 578262   Ensembl: ENSG000001237287   UniProtKB: Q9Y3L53   

Export aliases for RAP2C gene to outside databases

Previous GC identifers: GC0XM129282 GC0XM130042 GC0XM131062 GC0XM131164 GC0XM120741


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAP2C Gene:
The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily.
Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation,
differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of
the serum response element. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Sep 2012)

GeneCards Summary for RAP2C Gene: 
RAP2C (RAP2C, member of RAS oncogene family) is a protein-coding gene. Diseases associated with RAP2C include vesiculitis, and acute lymphoblastic leukemia, and among its related super-pathways are Rho Family GTPases. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is DIRAS1.

UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5
Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May
play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK.
May play a role in SRE-mediated gene transcription




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAP2C gene promoter:
         Nkx3-1   Nkx3-1 v1   POU3F2   c-Ets-1   Nkx3-1 v2   CREB   E2F   E2F-1   HOXA5   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAP2C promoter sequence
   Search SABiosciences Chromatin IP Primers for RAP2C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25   Ensembl cytogenetic band:  Xq26.2   HGNC cytogenetic band: Xq25

RAP2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP2C gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM131337:  view genomic region     (about GC identifiers)

Start:
131,337,053 bp from pter      End:
131,353,471 bp from pter
Size:
16,419 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5 (See protein sequence)
Recommended Name: Ras-related protein Rap-2c precursor  
Size: 183 amino acids; 20745 Da
Subcellular location: Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity)
Secondary accessions: B3KWD6 Q5H9H9 Q9BTS0

Explore the universe of human proteins at neXtProt for RAP2C: NX_Q9Y3L5

Explore proteomics data for RAP2C at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK
    (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3L5

  • RAP2C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAP2C Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001258115.1  NP_001258116.1  NP_067006.3  

    ENSEMBL proteins: 
     ENSP00000340274   ENSP00000359911  

    Human Recombinant Protein Products for RAP2C: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RAP2C
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RAP2C
    GenScript Custom Purified and Recombinant Proteins Services for RAP2C
    Novus Biologicals RAP2C Protein
    Novus Biologicals RAP2C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAP2C 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol IEA--
    GO:0016020membrane ----
    GO:0055037recycling endosome ----
    GO:0055038recycling endosome membrane ISS--

    RAP2C for ontologies           About GeneDecksing



    RAP2C Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RAP2C
    OriGene Custom Antibody Services for RAP2C
    GenScript Custom Superior Antibodies Services for RAP2C
    Novus Biologicals RAP2C Antibodies
    Abcam antibodies for RAP2C
    Cloud-Clone Corp. Antibodies for RAP2C 
    ThermoFisher Antibodies for RAP2C
    LSBio Antibodies in human, mouse, rat for RAP2C 

    Assay Products for RAP2C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAP2C
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAP2C
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAP2C 
    Cloud-Clone Corp. CLIAs for RAP2C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q9Y3L5

    ProtoNet protein and cluster: Q9Y3L5

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RAP2C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAP2C_HUMAN, Q9Y3L5
    Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May
    play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK.
    May play a role in SRE-mediated gene transcription

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
         
    RAP2C for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RAP2C:
     Big cells  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAP2C 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAP2C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAP2C 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAP2C 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAP2C
    8/105 QIAGEN miScript miRNA Assays for microRNAs that regulate RAP2C (see all 105):
    hsa-miR-3678-3p hsa-miR-607 hsa-miR-188-5p hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-30d hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidRAP2C 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAP2C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAP2C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAP2C
    Sirion Biotech Customized adenovirus for overexpression of RAP2C

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RAP2C (see all 10)
    OriGene ORF clones in mouse, rat for RAP2C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAP2C (NM_021183)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP2C
    Sirion Biotech Customized lentivirus for stable overexpression of RAP2C 
                         Customized lentivirus expression plasmids for stable overexpression of RAP2C 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAP2C
    Search LifeMap BioReagents cell lines for RAP2C
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAP2C About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho Family GTPases
    Molecular Mechanisms of Cancer0.51

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAP2C
        Molecular Mechanisms of Cancer


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAP2C

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/9 Interacting proteins for RAP2C (Q9Y3L53 ENSP000003402744) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    CSNK1EP496743I2D: score=1 
    CTNNB1P352223I2D: score=1 
    DVL2O146413I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----
    GO:0015031protein transport ----
    GO:0030336negative regulation of cell migration ISS--

    RAP2C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAP2C

    Search CenterWatch for drugs/clinical trials and news about RAP2C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAP2C gene (3 alternative transcripts): 
    NM_001271186.1  NM_001271187.1  NM_021183.4  

    Unigene Cluster for RAP2C:

    RAP2C, member of RAS oncogene family
    Hs.119889  [show with all ESTs]
    Unigene Representative Sequence: NM_001271186
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342983(uc004ewo.3 uc004ewp.3 uc010nrk.3 uc004ewq.4)
    ENST00000370874 ENST00000460462 ENST00000490400
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAP2C
    8/105 QIAGEN miScript miRNA Assays for microRNAs that regulate RAP2C (see all 105):
    hsa-miR-3678-3p hsa-miR-607 hsa-miR-188-5p hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-30d hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidRAP2C 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAP2C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAP2C
    Clone
    Products:
         
    OriGene clones in human, mouse for RAP2C (see all 10)
    OriGene ORF clones in mouse, rat for RAP2C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAP2C (NM_021183)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP2C
    Sirion Biotech Customized lentivirus for stable overexpression of RAP2C 
                         Customized lentivirus expression plasmids for stable overexpression of RAP2C 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RAP2C
    OriGene qSTAR qPCR primer pairs in human, mouse for RAP2C
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RAP2C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAP2C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP2C

    Additional mRNA sequence: 

    AF093744.1 AK124801.1 AL049685.2 AL832461.1 AY298955.1 BC003403.1 BC035382.1 BC051467.1 
    BX647223.1 NR_073150.1 

    7 DOTS entries:

    DT.111337  DT.97812656  DT.95080840  DT.91852181  DT.75132773  DT.92429142  DT.99996497 

    24/131 AceView cDNA sequences (see all 131):

    AW978491 BM450598 BE856717 BG613592 AK124801 AA588562 BU159641 AA635752 
    BX647223 AW089784 AI934005 BM126916 C01578 BF515127 BE327676 AA995170 
    BC035382 AL049685 AA046625 CD678940 NM_021183 AY298955 CD678323 BE256409 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAP2C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:              -     -           -     -     -     -     -                                       
    SP2:              -     -                 -                                                         
    SP3:                                -     -                                                         
    SP4:                                                                          -                     
    SP5:                                                                          -                     


    ECgene alternative splicing isoforms for RAP2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAP2C expression in normal human tissues (normalized intensities)      RAP2C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTAATGT
    RAP2C Expression
    About this image


    RAP2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 5 entries
             T Helper Cells Thymus
             Umbilical cord blood-derived hematopoietic stem cells
             bone marrow cd34+   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
             stem cells (umbilical cord cd34+)   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Uterus (Reproductive System)
             myometrium   
     
     Bone (Muscoskeletal System)
             mandibular prominence tissue e10.0   

    See RAP2C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAP2C

    SOURCE GeneReport for Unigene cluster: Hs.119889

    UniProtKB/Swiss-Prot: RAP2C_HUMAN, Q9Y3L5
    Tissue specificity: Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a
    lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes

        SABiosciences Custom PCR Arrays for RAP2C
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RAP2C
    OriGene qSTAR qPCR primer pairs in human, mouse for RAP2C
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RAP2C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAP2C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP2C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAP2C gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap2c1 , 5 RAP2C, member of RAS oncogene family1, 5 94.9(n)1
    100(a)1
      X (28.03 cM)5
    720651  NM_172413.21  NP_766001.11 
     510039125 
    chicken
    (Gallus gallus)
    Aves RAP2C6
    RAP2C, member of RAS oncogene family
    91(a)
    1 ↔ 1
    4(3456555-3458921)
    African clawed frog
    (Xenopus laevis)
    Amphibia rap2c-prov2 RAP2C, member of RAS oncogene family 81.37(n)    BC043998.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rap2c1 RAP2C, member of RAS oncogene family 76.32(n)
    92.9(a)
      474323  NM_001007055.1  NP_001007056.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rap2l6
    Ras-associated protein 2-like
    69(a)
    1 → many
    2R(19950576-19952928)
    worm
    (Caenorhabditis elegans)
    Secernentea rap-26
    Protein RAP-2
    69(a)
    1 → many
    V(15061263-15064087)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSR16
    GTP-binding protein of the ras superfamily require...
    34(a)
    1 → many
    VII(794674-795492)


    ENSEMBL Gene Tree for RAP2C (if available)
    TreeFam Gene Tree for RAP2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAP2C gene
    DIRAS12  RAP1B2  RALA2  RIT22  RAP2A2  RIT12  RALB2  RAP1A2  
    RAP2B2  NRAS2  DIRAS22  KRAS2  HRAS2  DIRAS32  
    18/97 SIMAP similar genes for RAP2C using alignment to 1 protein entry:     RAP2C_HUMAN(see all similar genes):
    RAP2A    DKFZp547A0616    RAP2B    RAP1B    c-bas/has    RAP1A
    RIT2    RIT1    DIRAS2    RALA    DIRAS1    RALB
    KRAS    MRAS    NRAS    HRAS    RERG    RRAS2

    RAP2C for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RAP2C
    PGOHUM00000248275 PGOHUM00000248277


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/212 SNPs in RAP2C are shown (see all 212)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864818511,2
    --131311174(+) AAAAAA/GATGGC 1 -- int10--------
    rs1828482891,2
    --131336827(+) TTTCTA/GTAATA 4 -- ds50010--------
    rs1472418341,2
    --131336901(+) GGAAAC/TAGGCG 4 -- ds50010--------
    rs1874800681,2
    --131336965(+) ATAAAA/CAGTAA 4 -- ds50010--------
    rs1931869361,2
    --131337005(+) GTTAGC/TAAATC 4 -- ds50010--------
    rs1854569531,2
    --131337391(+) TTGAGA/GAAGCT 4 -- ut31 nc-transcript-variant0--------
    rs1891320491,2
    --131337414(+) GGTCCC/TTTTTC 4 -- ut31 nc-transcript-variant0--------
    rs1921898451,2
    --131337443(+) ACCACA/CTTTAA 4 -- ut31 nc-transcript-variant0--------
    rs1836474741,2
    --131337611(+) TACAGA/GAAAGA 4 -- ut31 nc-transcript-variant0--------
    rs1883563441,2
    --131337954(+) TAGTCA/CATTTC 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for RAP2C (131337053 - 131353471 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RAP2C: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RAP2C
    DNA2.0 Custom Variant and Variant Library Synthesis for RAP2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    6 diseases for RAP2C:    About MalaCards
    vesiculitis    acute lymphoblastic leukemia    lymphoblastic leukemia    mental retardation
    leukemia    prostatitis


    RAP2C for disorders           About GeneDecksing


    Export disorders for RAP2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAP2C gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with RAP2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. (PubMed id 17447155)1, 2 Guo Z....Yu L. (2007)
    2. Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins. (PubMed id 16213650)1, 2 Paganini S.... Torti M. (2006)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A computational approach to candidate gene prioritiza tion for X-linked mental retardation using annotation-based binary filtering an d motif-based linear discriminatory analysis. (PubMed id 21668950)1 Lombard Z....Ramsay M. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57826 HGNC: 21165 AceView: RAP2C Ensembl:ENSG00000123728 euGenes: HUgn57826
    ECgene: RAP2C H-InvDB: RAP2C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAP2C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP2C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAP2C gene:
    Search GeneIP for patents involving RAP2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RAP2C   OriGene RNAi products in human, mouse, rat for RAP2C  
     OriGene qPCR primer pairs and template standards for RAP2C   OriGene Protein Over-expression Lysate for RAP2C  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RAP2C  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAP2C   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RAP2C   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAP2C   OriGene Custom Protein Services for RAP2C  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAP2C
     QIAGEN SeqTarget long-range PCR primers for resequencing RAP2C
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP2C
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAP2C
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP2C
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAP2C
     GenScript Custom Purified and Recombinant Proteins Services for RAP2C GenScript cDNA clones with any tag delivered in your preferred vector for RAP2C
     GenScript Custom Assay Services for RAP2C GenScript Custom Superior Antibodies Services for RAP2C
     GenScript Custom overexpressing Cell Line Services for RAP2C CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RAP2C promoter
     Search Chromatin IP Primers for RAP2C
     RT2 qPCR Primer Assay in human, mouse / rat RAP2C
     Search GNC Networks for RAP2C
     SABiosciences PCR Arrays including human, mouse, rat RAP2C
     Search Tocris compounds for RAP2C
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RAP2C antibodies
     RAP2C proteins
     RAP2C lysates
     Antibodies for RAP2C
     See all of Abcam's Antibodies, Kits and Proteins for RAP2C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RAP2C
     Antibodies for RAP2C
     ELISAs for RAP2C
     CLIAs for RAP2C
     Search LifeMap BioReagents cell lines for RAP2C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2C
     SwitchGear 3'UTR luciferase reporter plasmids for RAP2C
     SwitchGear Promoter luciferase reporter plasmids for RAP2C
     ThermoFisher Antibodies for RAP2C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP2C
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RAP2C
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAP2C
    Customized:
     lentivirus for stable overexpression of RAP2C
     lentivirus expression plasmids for stable overexpression of RAP2C
     adenovirus for overexpression of RAP2C
     LSBio Antibodies in human, mouse, rat for RAP2C
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAP2C gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4