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Aliases for RAP2C Gene

Aliases for RAP2C Gene

  • RAP2C, Member Of RAS Oncogene Family 2 3

External Ids for RAP2C Gene

Previous GeneCards Identifiers for RAP2C Gene

  • GC0XM129282
  • GC0XM130042
  • GC0XM131062
  • GC0XM131164
  • GC0XM131337
  • GC0XM120741

Summaries for RAP2C Gene

Entrez Gene Summary for RAP2C Gene

  • The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

GeneCards Summary for RAP2C Gene

RAP2C (RAP2C, Member Of RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are ERK Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for RAP2C Gene

  • Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP2C Gene

Genomics for RAP2C Gene

Regulatory Elements for RAP2C Gene

Genomic Location for RAP2C Gene

Start:
132,203,024 bp from pter
End:
132,219,480 bp from pter
Size:
16,457 bases
Orientation:
Minus strand

Genomic View for RAP2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAP2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP2C Gene

Proteins for RAP2C Gene

  • Protein details for RAP2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3L5-RAP2C_HUMAN
    Recommended name:
    Ras-related protein Rap-2c
    Protein Accession:
    Q9Y3L5
    Secondary Accessions:
    • B3KWD6
    • Q5H9H9
    • Q9BTS0

    Protein attributes for RAP2C Gene

    Size:
    183 amino acids
    Molecular mass:
    20745 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAP2C Gene

Proteomics data for RAP2C Gene at MOPED

Post-translational modifications for RAP2C Gene

  • Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK (By similarity).
  • Ubiquitination at Lys5 and Lys108
  • Modification sites at PhosphoSitePlus

Other Protein References for RAP2C Gene

No data available for DME Specific Peptides for RAP2C Gene

Domains for RAP2C Gene

Suggested Antigen Peptide Sequences for RAP2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3L5

UniProtKB/Swiss-Prot:

RAP2C_HUMAN :
  • Q9Y3L5
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RAP2C: view

No data available for Gene Families for RAP2C Gene

Function for RAP2C Gene

Molecular function for RAP2C Gene

UniProtKB/Swiss-Prot Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.

Gene Ontology (GO) - Molecular Function for RAP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 17447155
GO:0003924 GTPase activity --
GO:0005525 GTP binding IDA 16213650
GO:0019003 GDP binding IDA 16213650
genes like me logo Genes that share ontologies with RAP2C: view

Phenotypes for RAP2C Gene

GenomeRNAi human phenotypes for RAP2C:
genes like me logo Genes that share phenotypes with RAP2C: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAP2C Gene

Localization for RAP2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP2C Gene

Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAP2C Gene COMPARTMENTS Subcellular localization image for RAP2C gene
Compartment Confidence
endosome 5
cytosol 3
mitochondrion 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 17447155
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA 16213650
GO:0005923 bicellular tight junction IDA 23885123
genes like me logo Genes that share ontologies with RAP2C: view

Pathways for RAP2C Gene

SuperPathways for RAP2C Gene

Superpath Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with RAP2C: view

Pathways by source for RAP2C Gene

1 Qiagen pathway for RAP2C Gene

Gene Ontology (GO) - Biological Process for RAP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
GO:0015031 protein transport --
GO:0030033 NOT microvillus assembly IMP 22797597
genes like me logo Genes that share ontologies with RAP2C: view

Transcripts for RAP2C Gene

Unigene Clusters for RAP2C Gene

RAP2C, member of RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAP2C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for RAP2C Gene

GeneLoc Exon Structure for
RAP2C
ECgene alternative splicing isoforms for
RAP2C

Expression for RAP2C Gene

mRNA expression in normal human tissues for RAP2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAP2C Gene

This gene is overexpressed in Uterus (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAP2C Gene

SOURCE GeneReport for Unigene cluster for RAP2C Gene Hs.119889

mRNA Expression by UniProt/SwissProt for RAP2C Gene

Q9Y3L5-RAP2C_HUMAN
Tissue specificity: Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.
genes like me logo Genes that share expressions with RAP2C: view

Orthologs for RAP2C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAP2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAP2C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAP2C 35
  • 97.63 (n)
  • 100 (a)
RAP2C 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAP2C 35
  • 97.45 (n)
  • 100 (a)
RAP2C 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rap2c 35
  • 94.9 (n)
  • 100 (a)
Rap2c 16
Rap2c 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAP2C 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAP2C 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rap2c 35
  • 95.45 (n)
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia rap2c-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rap2c 35
  • 80.69 (n)
  • 96.72 (a)
Str.3585 35
zebrafish
(Danio rerio)
Actinopterygii rap2c 35
  • 76.32 (n)
  • 92.9 (a)
rap2c 36
  • 93 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Rap2l 36
  • 69 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rap-2 36
  • 70 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4500 35
Species with no ortholog for RAP2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP2C Gene

ENSEMBL:
Gene Tree for RAP2C (if available)
TreeFam:
Gene Tree for RAP2C (if available)

Paralogs for RAP2C Gene

Pseudogenes.org Pseudogenes for RAP2C Gene

genes like me logo Genes that share paralogs with RAP2C: view

Variants for RAP2C Gene

Sequence variations from dbSNP and Humsavar for RAP2C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs766517 -- 132,209,148(+) GCATA(G/T)AATCC intron-variant
rs2320484 -- 132,208,974(-) AATTC(C/G)AGCCT intron-variant
rs5933123 -- 132,208,526(+) TAAAT(C/T)GTTAT intron-variant
rs5933124 -- 132,215,122(+) TTTTT(G/T)TTTTT intron-variant
rs5977656 -- 132,206,260(+) TACTA(C/G)GTGCC intron-variant

Relevant External Links for RAP2C Gene

HapMap Linkage Disequilibrium report
RAP2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAP2C Gene

Disorders for RAP2C Gene

No disorders were found for RAP2C Gene.

No data available for UniProtKB/Swiss-Prot for RAP2C Gene

Publications for RAP2C Gene

  1. Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. (PMID: 17447155) Guo Z. … Yu L. (Mol. Biol. Rep. 2007) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins. (PMID: 16213650) Paganini S. … Torti M. (Biochimie 2006) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for RAP2C Gene

  • antibodies-online proteins for RAP2C
  • antibodies-online antibodies for RAP2C
  • antibodies-online kits for RAP2C

Sources for RAP2C Gene

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