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Aliases for RAP2B Gene

Aliases for RAP2B Gene

  • RAP2B, Member Of RAS Oncogene Family 2 3 5
  • Ras Family Small GTP Binding Protein RAP2B 2
  • Ras-Related Protein RAP-2B 2
  • Small GTP Binding Protein 2

External Ids for RAP2B Gene

Previous GeneCards Identifiers for RAP2B Gene

  • GC03P149859
  • GC03P153724
  • GC03P154161
  • GC03P154201
  • GC03P154200
  • GC03P154362
  • GC03P152880
  • GC03P150272

Summaries for RAP2B Gene

Entrez Gene Summary for RAP2B Gene

  • This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAP2B Gene

RAP2B (RAP2B, Member Of RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAP2B include Lung Squamous Cell Carcinoma. Among its related pathways are ERK Signaling and G-protein signaling G-Protein alpha-i signaling cascades. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is DIRAS2.

UniProtKB/Swiss-Prot for RAP2B Gene

  • Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.

Gene Wiki entry for RAP2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP2B Gene

Genomics for RAP2B Gene

Regulatory Elements for RAP2B Gene

Enhancers for RAP2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAP2B on UCSC Golden Path with GeneCards custom track

Promoters for RAP2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAP2B on UCSC Golden Path with GeneCards custom track

Genomic Location for RAP2B Gene

Chromosome:
3
Start:
153,162,212 bp from pter
End:
153,170,624 bp from pter
Size:
8,413 bases
Orientation:
Plus strand

Genomic View for RAP2B Gene

Genes around RAP2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAP2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP2B Gene

Proteins for RAP2B Gene

  • Protein details for RAP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61225-RAP2B_HUMAN
    Recommended name:
    Ras-related protein Rap-2b
    Protein Accession:
    P61225
    Secondary Accessions:
    • P17964
    • Q96EG5
    • Q9CXG0

    Protein attributes for RAP2B Gene

    Size:
    183 amino acids
    Molecular mass:
    20504 Da
    Quaternary structure:
    • Interacts with PLCE1. Interacts with SGSM1, SGSM2 and SGSM3. The GTP-bound form of RAP2B interacts with RUNDC3A (By similarity).

    Three dimensional structures from OCA and Proteopedia for RAP2B Gene

neXtProt entry for RAP2B Gene

Proteomics data for RAP2B Gene at MOPED

Post-translational modifications for RAP2B Gene

  • Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAP2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAP2B Gene

Domains & Families for RAP2B Gene

Gene Families for RAP2B Gene

Suggested Antigen Peptide Sequences for RAP2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61225

UniProtKB/Swiss-Prot:

RAP2B_HUMAN :
  • The effector domain mediates the interaction with RUNDC3A.
  • Belongs to the small GTPase superfamily. Ras family.
Domain:
  • The effector domain mediates the interaction with RUNDC3A.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RAP2B: view

Function for RAP2B Gene

Molecular function for RAP2B Gene

UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
genes like me logo Genes that share phenotypes with RAP2B: view

Animal Model Products

miRNA for RAP2B Gene

miRTarBase miRNAs that target RAP2B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAP2B Gene

Localization for RAP2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP2B Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Associated with red blood cells-released vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAP2B Gene COMPARTMENTS Subcellular localization image for RAP2B gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 16213650
GO:0045121 membrane raft IMP 18582561
GO:0055038 recycling endosome membrane IEA,ISS --
genes like me logo Genes that share ontologies with RAP2B: view

Pathways & Interactions for RAP2B Gene

genes like me logo Genes that share pathways with RAP2B: view

Pathways by source for RAP2B Gene

1 Qiagen pathway for RAP2B Gene

Gene Ontology (GO) - Biological Process for RAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,TAS 2118648
GO:0030168 platelet activation IDA 18582561
GO:0031954 positive regulation of protein autophosphorylation IEA --
GO:0061097 regulation of protein tyrosine kinase activity IEA,ISS --
GO:0090557 NOT establishment of endothelial intestinal barrier IMP 23885123
genes like me logo Genes that share ontologies with RAP2B: view

No data available for SIGNOR curated interactions for RAP2B Gene

Drugs & Compounds for RAP2B Gene

(1) Drugs for RAP2B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RAP2B: view

Transcripts for RAP2B Gene

mRNA/cDNA for RAP2B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(154) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAP2B Gene

RAP2B, member of RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAP2B Gene

No ASD Table

Relevant External Links for RAP2B Gene

GeneLoc Exon Structure for
RAP2B
ECgene alternative splicing isoforms for
RAP2B

Expression for RAP2B Gene

mRNA expression in normal human tissues for RAP2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAP2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.3), Bone (7.7), Platelet (7.5), and Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAP2B Gene



SOURCE GeneReport for Unigene cluster for RAP2B Gene Hs.98643

mRNA Expression by UniProt/SwissProt for RAP2B Gene

P61225-RAP2B_HUMAN
Tissue specificity: Expressed in red blood cells (at protein level).
genes like me logo Genes that share expression patterns with RAP2B: view

Protein tissue co-expression partners for RAP2B Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for RAP2B Gene

Orthologs for RAP2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAP2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAP2B 35
  • 93.81 (n)
  • 99.45 (a)
RAP2B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rap2b 35
  • 93.44 (n)
  • 100 (a)
Rap2b 16
Rap2b 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAP2B 35
  • 99.82 (n)
  • 100 (a)
RAP2B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rap2b 35
  • 93.26 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia RAP2B 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAP2B 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAP2C 36
  • 87 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia RAP2B 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rap2b 35
  • 83.52 (n)
  • 95.6 (a)
Str.6887 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1322 35
zebrafish
(Danio rerio)
Actinopterygii rap2b 35
  • 90.48 (n)
  • 96.15 (a)
srnyz128 35
rap2b 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rap2l 37
  • 67 (a)
Rap2l 35
  • 62.09 (n)
  • 68.13 (a)
Rap2l 36
  • 69 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004769 35
  • 62.27 (n)
  • 68.13 (a)
worm
(Caenorhabditis elegans)
Secernentea C08F8.7 37
  • 48 (a)
C25D7.7 37
  • 60 (a)
rap-2 36
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 36
  • 36 (a)
OneToMany
Species with no ortholog for RAP2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP2B Gene

ENSEMBL:
Gene Tree for RAP2B (if available)
TreeFam:
Gene Tree for RAP2B (if available)

Paralogs for RAP2B Gene

genes like me logo Genes that share paralogs with RAP2B: view

Variants for RAP2B Gene

Sequence variations from dbSNP and Humsavar for RAP2B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs728723 -- 153,168,289(+) ATTTA(C/G)AAAGT utr-variant-3-prime
rs501072 -- 153,163,559(-) CTTGG(G/T)GGGTG utr-variant-3-prime
rs523085 -- 153,163,665(+) ctttc(C/T)ttttt utr-variant-3-prime
rs894801 -- 153,161,049(-) GTCAC(G/T)ACTGC upstream-variant-2KB
rs894802 -- 153,160,930(-) CCACT(G/T)GGAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAP2B Gene

Variant ID Type Subtype PubMed ID
nsv820284 CNV Gain 19587683

Variation tolerance for RAP2B Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAP2B Gene

Disorders for RAP2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAP2B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search RAP2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAP2B

Genetic Association Database (GAD)
RAP2B
Human Genome Epidemiology (HuGE) Navigator
RAP2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAP2B
genes like me logo Genes that share disorders with RAP2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAP2B Gene

Publications for RAP2B Gene

  1. RAP2B: a RAS-related GTP-binding protein from platelets. (PMID: 2118648) Ohmstede C.A. … Lapetina E.G. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 67
  2. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  3. miR-342-3p targets RAP2B to suppress proliferation and invasion of non-small cell lung cancer cells. (PMID: 25663460) Xie X. … Mei J. (Tumour Biol. 2015) 3
  4. p53 target gene Rap2B regulates the cytoskeleton and inhibits cell spreading. (PMID: 25762091) Di J. … Zheng J. (J. Cancer Res. Clin. Oncol. 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for RAP2B Gene

Sources for RAP2B Gene

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