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RAP2B Gene

protein-coding   GIFtS: 64
GCID: GC03P152880

RAP2B, Member Of RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAP2B, Member Of RAS Oncogene Family1 2
Ras-Related Protein RAP-2B1 2
Small GTP Binding Protein1 2
Ras Family Small GTP Binding Protein RAP2B1

External Ids:    HGNC: 98621   Entrez Gene: 59122   Ensembl: ENSG000001814677   OMIM: 1795415   UniProtKB: P612253   

Export aliases for RAP2B gene to outside databases

Previous GC identifers: GC03P149859 GC03P153724 GC03P154161 GC03P154201 GC03P154200 GC03P154362 GC03P150272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAP2B Gene:
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share
approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in
common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine
in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and
palmitoylated. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAP2B Gene:
RAP2B (RAP2B, member of RAS oncogene family) is a protein-coding gene. Diseases associated with RAP2B include vesiculitis, and lung squamous cell carcinoma. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225
Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.
Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal
rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane
vesiculation in red blood cells

Gene Wiki entry for RAP2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAP2B gene promoter:
         AhR   FOXD3   Arnt   FOXL1   CREB   Egr-2   HSF2   deltaCREB   Msx-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAP2B promoter sequence
   Search Chromatin IP Primers for RAP2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAP2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.2   Ensembl cytogenetic band:  3q25.2   HGNC cytogenetic band: 3q25.2

RAP2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP2B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P152880:  view genomic region     (about GC identifiers)

Start:
152,880,029 bp from pter      End:
152,886,265 bp from pter
Size:
6,237 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225 (See protein sequence)
Recommended Name: Ras-related protein Rap-2b precursor  
Size: 183 amino acids; 20504 Da
Subunit: Interacts with PLCE1. Interacts with SGSM1, SGSM2 and SGSM3. The GTP-bound form of RAP2B interacts with
RUNDC3A (By similarity)
Secondary accessions: P17964 Q96EG5 Q9CXG0

Explore the universe of human proteins at neXtProt for RAP2B: NX_P61225

Explore proteomics data for RAP2B at MOPED

Post-translational modifications: 

  • Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK
    (By similarity)1
  • Ubiquitination2 at Lys5
  • Modification sites at PhosphoSitePlus

  • See RAP2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002877.2  
    ENSEMBL proteins: 
     ENSP00000319096  

    RAP2B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P61225

    ProtoNet protein and cluster: P61225

    3 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225
    Domain: The effector domain mediates the interaction with RUNDC3A (By similarity)
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RAP2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAP2B_HUMAN, P61225
    Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.
    Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal
    rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane
    vesiculation in red blood cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IDA16213650
    GO:0019003GDP binding IDA16213650
    GO:0019904protein domain specific binding IEA--
         
    RAP2B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAP2B:
     Decreased viability of wild-ty  Increased cilium length after   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAP2B
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    miRNA
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    miRTarBase miRNAs that target RAP2B:
    hsa-mir-324-5p (MIRT043238), hsa-mir-378a-5p (MIRT044000)

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    Selected qRT-PCR Assays for microRNAs that regulate RAP2B (see all 106):
    hsa-miR-579 hsa-miR-576-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-1260b hsa-miR-30d hsa-miR-3074-3p hsa-miR-342-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAP2B_HUMAN, P61225: Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Associated with red blood
    cells-released vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    cytoskeleton2
    golgi apparatus2
    plasma membrane2
    vacuole2
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IDA16213650
    GO:0016020membrane ----
    GO:0055037recycling endosome ----

    RAP2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAP2B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G protein signaling G Protein alpha i signaling cascades
    Development Beta adrenergic receptors regulation of ERK0.55
    2ERK Signaling
    Molecular Mechanisms of Cancer0.51
    3G protein signaling Rap2B regulation pathway
    G protein signaling Rap2B regulation pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAP2B
        Molecular Mechanisms of Cancer

    2 GeneGo (Thomson Reuters) Pathways for RAP2B
        G-protein signaling Rap2B regulation pathway
    Development Beta-adrenergic receptors regulation of ERK


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAP2B
    Interactions:

        GeneGlobe Interaction Network for RAP2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAP2B (P612252, 3 ENSP000003190964) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUNDC3AQ59EK92, 3, ENSP000004108624MINT-67921 I2D: score=5 STRING: ENSP00000410862
    RAPGEF2Q9Y4G83, ENSP000002644314I2D: score=2 STRING: ENSP00000264431
    RALGDSQ129673, ENSP000003611204I2D: score=2 STRING: ENSP00000361120
    RALAP112333, ENSP000000052574I2D: score=1 STRING: ENSP00000005257
    RAPGEF5Q925653, ENSP000003436564I2D: score=1 STRING: ENSP00000343656
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IEA--
    GO:0007165signal transduction TAS2118648
    GO:0007264small GTPase mediated signal transduction ----
    GO:0015031protein transport ----
    GO:0030336negative regulation of cell migration IEA--

    RAP2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAP2B

    1 HMDB Compound for RAP2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RAP2B gene: 
    NM_002886.3  

    Unigene Cluster for RAP2B:

    RAP2B, member of RAS oncogene family
    Hs.98643  [show with all ESTs]
    Unigene Representative Sequence: NM_002886
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000323534(uc003ezr.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RAP2B (see all 106):
    hsa-miR-579 hsa-miR-576-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-1260b hsa-miR-30d hsa-miR-3074-3p hsa-miR-342-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QuantiTect SYBR Green Assays in human, mouse, rat RAP2B
      QuantiFast Probe-based Assays in human, mouse, rat RAP2B

    Additional mRNA sequence: 

    AF493915.1 AL713766.1 BC012362.1 X52987.1 

    7 DOTS entries:

    DT.91782119  DT.456382  DT.95369655  DT.100827522  DT.100758269  DT.101966301  DT.99971147 

    Selected AceView cDNA sequences (see all 154):

    CB128838 BF477820 AI914301 N47069 BM783191 AA496974 BM994084 N24902 
    AA429990 AF493915 AA515514 AA258424 BF062479 AI452392 BF965860 BF475296 
    BX116683 AI190283 CN480624 NM_002886 AA490572 CA311464 BE045429 BM692947 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAP2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RAP2B Expression
    About this image

    RAP2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAP2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98643

    UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225
    Tissue specificity: Expressed in red blood cells (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAP2B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap2b1 , 5 RAP2B, member of RAS oncogene family1, 5 93.44(n)1
    100(a)1
      3 (29.81 cM)5
    740121  NM_028712.41  NP_082988.11 
     613645075 
    chicken
    (Gallus gallus)
    Aves RAP2C6
    Gallus gallus RAP2C, member of RAS oncogene family...
    87(a)
    many ↔ many
    4(3456555-3458921)
    lizard
    (Anolis carolinensis)
    Reptilia RAP2B6
    RAP2B, member of RAS oncogene family
    97(a)
    1 ↔ 1
    3(17061473-17062024)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.13222 Xenopus laevis transcribed sequence with strong similarity more 84.16(n)    BU916667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srnyz1282 Danio rerio cDNA clone MGC55550 IMAGE2642754, complete more 87.59(n)    BC054999.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rap2l1 , 3 RAS small monomeric GTPase3
    Ras-associated protein 2-like1
    67(a)3
    62.09(n)1
    68.13(a)1
      60B73
    378501  NM_058054.31  NP_477402.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C25D7.73 RAS-related protein 60(a)
    (best of 2)
      V(15064493-15066667)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSR16
    GTP-binding protein of the ras superfamily require...
    36(a)
    1 → many
    VII(794674-795492) YGR152C


    ENSEMBL Gene Tree for RAP2B (if available)
    TreeFam Gene Tree for RAP2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for RAP2B gene
    RAP2C2  RASL10B2  DIRAS12  RAP1B2  RASD22  RIT22  RAP2A2  RIT12  
    RAP1A2  RASD12  DIRAS22  RASL10A2  DIRAS32  
    Selected SIMAP similar genes for RAP2B using alignment to 1 protein entry:     RAP2B_HUMAN(see all similar genes):
    DKFZp547A0616    RAP2A    RAP2C    RAP1B    RIT2    c-bas/has
    RAP1A    RIT1    RALA    DIRAS2    DIRAS1    RRAS2
    RALB    MRAS    RERG    KRAS    NRAS    HRAS

    RAP2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAP2B (see all 167)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875402951,2
    --152878077(+) ACATTA/GGGTGG 1 -- us2k10--------
    rs1420052951,2
    --152878093(+) GACAGG/TGTTCT 1 -- us2k10--------
    rs1442812941,2
    C--152878237(+) CACCAC/TCCACC 1 -- us2k10--------
    rs764849381,2
    C--152878322(+) GGAAGA/CTGCTT 1 -- us2k10--------
    rs1929874171,2
    C--152878393(+) TGAAAA/C/GCGTGT 1 -- us2k10--------
    rs1829787961,2
    --152878586(+) ACAAGA/TCGGGG 1 -- us2k10--------
    rs8948021,2
    C,F,A,H--152878719(-) CCACTT/GGGAAT 1 -- us2k121Minor allele frequency- G:0.23NS EA NA WA CSA 2348
    rs1886642291,2
    --152878742(+) CCTCGC/TCCCCT 1 -- us2k10--------
    rs8948011,2
    C,F,O,H--152878838(-) GTCACG/TACTGC 1 -- us2k123Minor allele frequency- T:0.07NA EA MN NS WA 2774
    rs1412434441,2
    C--152878839(+) CAGTCA/GTGACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAP2B (152880029 - 152886265 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RAP2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820284CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179541    OMIM disorders: --

    11 diseases for RAP2B:    About MalaCards
    vesiculitis    lung squamous cell carcinoma    platelet storage pool deficiency    intrahepatic cholangiocarcinoma
    squamous cell carcinoma    malaria    cholangiocarcinoma    retinitis
    schizophrenia    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for RAP2B:
    Platelet storage pool deficiency

    RAP2B for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAP2B
    Human Genome Epidemiology (HuGE) Navigator: RAP2B (3 documents)

    Export disorders for RAP2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAP2B gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with RAP2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RAP2B: a RAS-related GTP-binding protein from platelets. (PubMed id 2118648)1, 2, 3 Ohmstede C.A.... Lapetina E.G. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. (PubMed id 11877431)1, 2 Evellin S.... Schmidt M. (J. Biol. Chem. 2002)
    5. Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. (PubMed id 12444546)1, 2 Song C.... Kataoka T. (Oncogene 2002)
    6. Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. (PubMed id 8424780)1, 2 Farrell F.X.... Lapetina E.G. (Biochem. J. 1993)
    7. cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2. (PubMed id 2115998)1, 2 Farrell F.X.... Lapetina E.G. (Nucleic Acids Res. 1990)
    8. Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3. (PubMed id 15143162)2, 9 Stope M.B.... Schmidt M. (Mol. Cell. Biol. 2004)
    9. Rap2b, a novel p53 target, regulates p53-mediated pro-survival function. (PubMed id 23535297)1 Zhang X....Huang J. (Cell Cycle 2013)
    10. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5912 HGNC: 9862 AceView: RAP2B Ensembl:ENSG00000181467 euGenes: HUgn5912
    ECgene: RAP2B H-InvDB: RAP2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAP2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP2B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAP2B gene:
    Search GeneIP for patents involving RAP2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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