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Aliases for RAP2B Gene

Aliases for RAP2B Gene

  • RAP2B, Member Of RAS Oncogene Family 2 3 5
  • Ras Family Small GTP Binding Protein RAP2B 2
  • Ras-Related Protein RAP-2B 2
  • Small GTP Binding Protein 2

External Ids for RAP2B Gene

Previous GeneCards Identifiers for RAP2B Gene

  • GC03P149859
  • GC03P153724
  • GC03P154161
  • GC03P154201
  • GC03P154200
  • GC03P154362
  • GC03P152880
  • GC03P150272

Summaries for RAP2B Gene

Entrez Gene Summary for RAP2B Gene

  • This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAP2B Gene

RAP2B (RAP2B, Member Of RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAP2B include Hypotrichosis 3 and Cardiomyopathy, Dilated, 1P. Among its related pathways are G-protein signaling_Rap2B regulation pathway and Innate Immune System. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAP2A.

UniProtKB/Swiss-Prot for RAP2B Gene

  • Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.

Gene Wiki entry for RAP2B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP2B Gene

Genomics for RAP2B Gene

Regulatory Elements for RAP2B Gene

Enhancers for RAP2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G153246 1.4 FANTOM5 Ensembl ENCODE 27.1 +85.3 85283 1.8 HINFP DDX20 CHAMP1 FOSL1 TCF12 FOXM1 TRIM24 FOS CAVIN1 ZNF740 RAP2B ENSG00000244268 P2RY1 LOC105374164 LOC105374166
GH03G153137 2 FANTOM5 Ensembl ENCODE dbSUPER 17.6 -22.5 -22460 4.8 FOXA2 PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 RAP2B ENSG00000244268 LOC105374163 LOC100418712
GH03G153288 1.6 FANTOM5 Ensembl ENCODE 21.9 +127.3 127279 1.0 TBP PKNOX1 ATF1 CBX3 TBL1XR1 NFRKB ZBTB40 CHAMP1 CAVIN1 ZNF592 RAP2B ENSG00000244268 P2RY1 LOC105374166 LOC105374164
GH03G153283 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +123.6 123600 4.8 HDAC1 PKNOX1 ATF1 SIN3A ZNF766 GATA2 SCRT2 FOS CREM CEBPB RAP2B ENSG00000244268 P2RY1 LOC105374166 LOC105374164
GH03G153251 1 FANTOM5 Ensembl 24.2 +88.5 88487 0.2 JUN DPF2 CHAMP1 ZNF592 FOSL1 NFIC JUND SMARCA4 ATF3 FOSL2 RAP2B ENSG00000244268 P2RY1 LOC105374164 LOC105374166
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAP2B on UCSC Golden Path with GeneCards custom track

Promoters for RAP2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160480 988 6001 CREB3L1 FEZF1 DMAP1 YY1 ZNF263 SP3 NFYC TBX21 MEF2D ZNF610

Genomic Location for RAP2B Gene

Chromosome:
3
Start:
153,162,212 bp from pter
End:
153,170,624 bp from pter
Size:
8,413 bases
Orientation:
Plus strand

Genomic View for RAP2B Gene

Genes around RAP2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAP2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP2B Gene

Proteins for RAP2B Gene

  • Protein details for RAP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61225-RAP2B_HUMAN
    Recommended name:
    Ras-related protein Rap-2b
    Protein Accession:
    P61225
    Secondary Accessions:
    • P17964
    • Q96EG5
    • Q9CXG0

    Protein attributes for RAP2B Gene

    Size:
    183 amino acids
    Molecular mass:
    20504 Da
    Quaternary structure:
    • Interacts with PLCE1. Interacts with SGSM1, SGSM2 and SGSM3. The GTP-bound form of RAP2B interacts with RUNDC3A (By similarity).

    Three dimensional structures from OCA and Proteopedia for RAP2B Gene

neXtProt entry for RAP2B Gene

Post-translational modifications for RAP2B Gene

  • Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAP2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAP2B Gene

Domains & Families for RAP2B Gene

Gene Families for RAP2B Gene

Suggested Antigen Peptide Sequences for RAP2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61225

UniProtKB/Swiss-Prot:

RAP2B_HUMAN :
  • The effector domain mediates the interaction with RUNDC3A.
  • Belongs to the small GTPase superfamily. Ras family.
Domain:
  • The effector domain mediates the interaction with RUNDC3A.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RAP2B: view

Function for RAP2B Gene

Molecular function for RAP2B Gene

UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.

Gene Ontology (GO) - Molecular Function for RAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IDA,TAS 16213650
GO:0019003 GDP binding IDA 16213650
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with RAP2B: view
genes like me logo Genes that share phenotypes with RAP2B: view

Animal Models for RAP2B Gene

MGI Knock Outs for RAP2B:

Animal Model Products

CRISPR Products

miRNA for RAP2B Gene

miRTarBase miRNAs that target RAP2B

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAP2B Gene

Localization for RAP2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP2B Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Associated with red blood cells-released vesicles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAP2B gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
endosome 5
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005829 cytosol IDA 18582561
GO:0005886 plasma membrane TAS --
GO:0005923 bicellular tight junction IDA 23885123
GO:0016020 membrane IMP 18582561
genes like me logo Genes that share ontologies with RAP2B: view

Pathways & Interactions for RAP2B Gene

genes like me logo Genes that share pathways with RAP2B: view

Pathways by source for RAP2B Gene

1 Qiagen pathway for RAP2B Gene

Gene Ontology (GO) - Biological Process for RAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 2118648
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0030033 NOT microvillus assembly IMP 22797597
GO:0030168 platelet activation IDA 18582561
GO:0030336 negative regulation of cell migration IEA --
genes like me logo Genes that share ontologies with RAP2B: view

No data available for SIGNOR curated interactions for RAP2B Gene

Drugs & Compounds for RAP2B Gene

(1) Drugs for RAP2B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RAP2B: view

Transcripts for RAP2B Gene

mRNA/cDNA for RAP2B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(154) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAP2B Gene

RAP2B, member of RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAP2B Gene

No ASD Table

Relevant External Links for RAP2B Gene

GeneLoc Exon Structure for
RAP2B
ECgene alternative splicing isoforms for
RAP2B

Expression for RAP2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAP2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAP2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.3), Bone (7.7), Platelet (7.5), and Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAP2B Gene



Protein tissue co-expression partners for RAP2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAP2B Gene:

RAP2B

SOURCE GeneReport for Unigene cluster for RAP2B Gene:

Hs.98643

mRNA Expression by UniProt/SwissProt for RAP2B Gene:

P61225-RAP2B_HUMAN
Tissue specificity: Expressed in red blood cells (at protein level).

Evidence on tissue expression from TISSUES for RAP2B Gene

  • Nervous system(4.5)
  • Blood(4.4)
  • Heart(2)
genes like me logo Genes that share expression patterns with RAP2B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAP2B Gene

Orthologs for RAP2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAP2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAP2B 34 35
  • 99.82 (n)
oppossum
(Monodelphis domestica)
Mammalia RAP2B 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAP2B 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAP2B 34 35
  • 93.81 (n)
mouse
(Mus musculus)
Mammalia Rap2b 34 16 35
  • 93.44 (n)
rat
(Rattus norvegicus)
Mammalia Rap2b 34
  • 93.26 (n)
chicken
(Gallus gallus)
Aves RAP2C 35
  • 87 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia RAP2B 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rap2b 34
  • 83.52 (n)
Str.6887 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1322 34
zebrafish
(Danio rerio)
Actinopterygii rap2b 34 35
  • 90.48 (n)
srnyz128 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004769 34
  • 62.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rap2l 36 34 35
  • 62.09 (n)
worm
(Caenorhabditis elegans)
Secernentea rap-2 35
  • 69 (a)
OneToMany
C25D7.7 36
  • 60 (a)
C08F8.7 36
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 35
  • 36 (a)
OneToMany
Species where no ortholog for RAP2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP2B Gene

ENSEMBL:
Gene Tree for RAP2B (if available)
TreeFam:
Gene Tree for RAP2B (if available)

Paralogs for RAP2B Gene

genes like me logo Genes that share paralogs with RAP2B: view

Variants for RAP2B Gene

Sequence variations from dbSNP and Humsavar for RAP2B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000232261 -- 153,164,409(+) GAGCC(A/G)GGACA utr-variant-3-prime
rs1000350759 -- 153,168,952(+) TGTTA(A/T)TATGG utr-variant-3-prime
rs1000409886 -- 153,170,397(+) ACTTA(A/G)AAGAG utr-variant-3-prime
rs1000586004 -- 153,162,125(+) AAAAC(C/G)AGGAG upstream-variant-2KB
rs1000676910 -- 153,170,572(+) CATTG(A/G)GCCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAP2B Gene

Variant ID Type Subtype PubMed ID
nsv820284 CNV gain 19587683
nsv954496 CNV duplication 24416366
nsv998158 CNV gain 25217958
nsv998184 CNV gain 25217958

Variation tolerance for RAP2B Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAP2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAP2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAP2B Gene

Disorders for RAP2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAP2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypotrichosis 3
  • htss2
cardiomyopathy, dilated, 1p
  • dilated cardiomyopathy 1p
- elite association - COSMIC cancer census association via MalaCards
Search RAP2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAP2B

Genetic Association Database (GAD)
RAP2B
Human Genome Epidemiology (HuGE) Navigator
RAP2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAP2B
genes like me logo Genes that share disorders with RAP2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAP2B Gene

Publications for RAP2B Gene

  1. RAP2B: a RAS-related GTP-binding protein from platelets. (PMID: 2118648) Ohmstede C.A. … Lapetina E.G. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation. (PMID: 16540189) Greco F. … Torti M. (Biochim. Biophys. Acta 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3. (PMID: 15143162) Stope M.B. … Schmidt M. (Mol. Cell. Biol. 2004) 4 22 64

Products for RAP2B Gene

Sources for RAP2B Gene

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