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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RAP2B Gene

protein-coding GIFtS: 60
GCID: GC03P152880

RAP2B, member of RAS oncogene family

Explore 6 diseases affiliated with
RAP2B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAP2B, Member Of RAS Oncogene Family¹ ²
Ras Family Small GTP Binding Protein RAP2B²
Ras-Related Protein Rap-2b²
Small GTP Binding Protein²

External Ids:	HGNC: 9862¹	Entrez Gene: 5912²	Ensembl: ENSG00000181467⁷	OMIM: 179541⁵	UniProtKB: P61225³

Export aliases for RAP2B gene to outside databases

Previous GC identifers: GC03P149859 GC03P153724 GC03P154161 GC03P154201 GC03P154200 GC03P154362 GC03P150272

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAP2B:

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately

50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most

striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by

threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225

Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in

EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and

regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells

Gene Wiki entry for RAP2B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RAP2B gene promoter:
AhR FOXD3 Arnt FOXL1 CREB Egr-2 HSF2 deltaCREB Msx-1 CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAP2B promoter sequence

Search SABiosciences Chromatin IP Primers for RAP2B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP2B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.2 Ensembl cytogenetic band: 3q25.2 HGNC cytogenetic band: 3q25.2

RAP2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP2B gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P152880: view genomic region (about GC identifiers)

Start:	152,880,029 bp from pter	End:	152,886,265 bp from pter
Size:	6,237 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225 (See protein sequence)

Recommended Name: Ras-related protein Rap-2b precursor

Size: 183 amino acids; 20504 Da

Subunit: Interacts with PLCE1. Interacts with SGSM1, SGSM2 and SGSM3. The GTP-bound form of RAP2B interacts with

RUNDC3A (By similarity)

Subcellular location: Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Associated with red blood

cells-released vesicles

Secondary accessions: P17964 Q96EG5 Q9CXG0

Explore the universe of human proteins at neXtProt for RAP2B: NX_P61225

Post-translational modifications:

Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK (By

similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61225

RAP2B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002877.2

ENSEMBL proteins:

ENSP00000319096

Human Recombinant Protein Products:

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	Uscn Proteins for RAP2B

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IEA	--
GO:0016020	membrane	--	--
GO:0055037	recycling endosome	--	--
GO:0055038	recycling endosome membrane	ISS	--

RAP2B for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RAP2B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RAP2B for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry P61225

ProtoNet protein and cluster: P61225

3 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003577 Ras small GTPase

IPB003578 Ras small GTPase

UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225

Domain: The effector domain mediates the interaction with RUNDC3A (By similarity)

Similarity: Belongs to the small GTPase superfamily. Ras family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225

Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in

EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and

regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells

miRNA Products:		OriGene 3'-UTR Clone: RAP2B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAP2B
		8/106 QIAGEN miScript miRNA Assays for microRNAs that regulate RAP2B (see all 106):
		hsa-miR-579 hsa-miR-576-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-1260b hsa-miR-30d hsa-miR-3074-3p hsa-miR-342-3p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2B

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005525	GTP binding	IEA	--
GO:0019904	protein domain specific binding	IEA	--

RAP2B for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for RAP2B:

Decreased viability of wild-ty

Increased cilium length after

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling_G-Protein alpha-i signaling cascades

Development Beta-adrenergic receptors regulation of ERK

0.55

Development_Beta-adrenergic receptors regulation of ERK

0.55

G-protein signaling_RhoA regulation pathway

G-protein signaling Rap2B regulation pathway

0.04

G-protein signaling_Rap2B regulation pathway

0.04

Rho Family GTPases

Molecular Mechanisms of Cancer

0.51

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for RAP2B

	Development Beta-adrenergic receptors regulation of ERK
	G-protein signaling Rap2B regulation pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAP2B

Molecular Mechanisms of Cancer

2 GeneGo (Thomson Reuters) Pathways for RAP2B

	G-protein signaling Rap2B regulation pathway
	Development Beta-adrenergic receptors regulation of ERK

RAP2B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RAP2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/8 Interacting proteins for RAP2B (P61225^{2, 3} ENSP00000319096⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RUNDC3A	Q59EK9²^,³, ENSP00000410862⁴	MINT-67921 I2D: score=5 STRING: ENSP00000410862
RAPGEF2	Q9Y4G8³, ENSP00000264431⁴	I2D: score=2 STRING: ENSP00000264431
RALGDS	Q12967³, ENSP00000361120⁴	I2D: score=2 STRING: ENSP00000361120
RALA	P11233³, ENSP00000005257⁴	I2D: score=1 STRING: ENSP00000005257
RAPGEF5	Q92565³, ENSP00000343656⁴	I2D: score=1 STRING: ENSP00000343656

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	2118648
GO:0030336	negative regulation of cell migration	IEA	--
GO:0031954	positive regulation of protein autophosphorylation	IEA	--
GO:0032486	Rap protein signal transduction	ISS	--
GO:0061097	regulation of protein tyrosine kinase activity	ISS	--

RAP2B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RAP2B

1 HMDB Compound for RAP2B About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about RAP2B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RAP2B gene:

NM_002886.2

Unigene Cluster for RAP2B:

RAP2B, member of RAS oncogene family

Hs.98643 [show with all ESTs]

Unigene Representative Sequence: NM_002886

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000323534(uc003ezr.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAP2B
		8/106 QIAGEN miScript miRNA Assays for microRNAs that regulate RAP2B (see all 106):
		hsa-miR-579 hsa-miR-576-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-1260b hsa-miR-30d hsa-miR-3074-3p hsa-miR-342-3p

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAP2B (see all 7) OriGene shRNA RFP: RAP2B OriGene siRNA: RAP2B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAP2B

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP2B

Additional cDNA sequence:

AF493915.1 AL713766.1 BC012362.1 X52987.1

7 DOTS entries:

DT.91782119 DT.456382 DT.95369655 DT.100827522 DT.100758269 DT.101966301 DT.99971147

24/154 AceView cDNA sequences (see all 154):

AA232794 AI914301 BQ016053 CN480624 AI190283 BF965860 BX492988 BF062479

BX283172 BF477820 AA233853 N24902 BF475296 AI435043 BE045429 AW005535

AA446133 BM994084 AF493915 AA258424 AW674886 AA496974 N36816 AI087344

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAP2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RAP2B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RAP2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAP2B

SOURCE GeneReport for Unigene cluster: Hs.98643

UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225

Tissue specificity: Expressed in red blood cells (at protein level)

SABiosciences Custom PCR Arrays for RAP2B

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RAP2B gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	RAP2B⁶	--	97(a)	1 ↔ 1	3(17061473-17062024)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1322²	Xenopus laevis transcribed sequence with strong similarity more	84.16(n)		BU916667.1
zebrafish (Danio rerio)	Actinopterygii	srnyz128²	Danio rerio cDNA clone MGC55550 IMAGE2642754, complete more	87.59(n)		BC054999.1
fruit fly (Drosophila melanogaster)	Insecta	Rap2l^{1 , 3}	RAS small monomeric GTPase³ Ras-associated protein 2-like¹	67(a)³ 62.09(n)¹ 68.13(a)¹		60B7³ 37850¹ NM_058054.3¹ NP_477402.1¹
worm (Caenorhabditis elegans)	Secernentea	C25D7.7³	RAS-related protein	60(a) (best of 2)		V(15064493-15066667) --

ENSEMBL Gene Tree for RAP2B (if available)
TreeFam Gene Tree for RAP2B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RAP2B gene

RAP2C² RASL10B² DIRAS1² RAP1B² RASD2² RAP2A² RAP1A² RASD1²

DIRAS2² RASL10A² DIRAS3²

18/104 SIMAP similar genes for RAP2B using alignment to 1 protein entry: RAP2B_HUMAN(see all similar genes):

DKFZp547A0616 RAP2A RAP2C RAP1B RIT2 c-bas/has

RAP1A RIT1 RALA DIRAS2 DIRAS1 RRAS2

RALB MRAS RERG KRAS NRAS HRAS

RAP2B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187540295^1,2		--	152878077(+)	`ACATTA/GGGTGG`	1	--	us2k¹		0	--	--	--	--
rs142005295^1,2		--	152878093(+)	`GACAGG/TGTTCT`	1	--	us2k¹		0	--	--	--	--
rs144281294^1,2		--	152878237(+)	`CACCAC/TCCACC`	1	--	us2k¹		0	--	--	--	--
rs76484938^1,2		--	152878322(+)	`GGAAGA/CTGCTT`	1	--	us2k¹		0	--	--	--	--
rs192987417^1,2		--	152878393(+)	`TGAAAA/C/GCGTGT`	1	--	us2k¹		0	--	--	--	--
rs182978796^1,2		--	152878586(+)	`ACAAGA/TCGGGG`	1	--	us2k¹		0	--	--	--	--
rs894802^1,2	C,F,A,H,	--	152878719(-)	`CCACTT/GGGAAT`	1	--	us2k¹		21		NS EA NA WA CSA	2348
rs188664229^1,2		--	152878742(+)	`CCTCGC/TCCCCT`	1	--	us2k¹		0	--	--	--	--
rs894801^1,2	C,F,O,H,	--	152878838(-)	`GTCACG/TACTGC`	1	--	us2k¹		23		NA EA MN NS WA	2774
rs141243444^1,2		--	152878839(+)	`CAGTCA/GTGACT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RAP2B (152880029 - 152886265 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for RAP2B
3 CNVs: 79969 79970 91644
2 Indels: 91645 59099

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAP2B

DNA2.0 Custom Variant and Variant Library Synthesis for RAP2B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RAP2B for disorders           About GeneDecksing

OMIM gene information: 179541    OMIM disorders: --

6 diseases for RAP2B:    About MalaCards

platelet storage pool deficiency squamous cell carcinoma lung squamous cell carcinoma carcinoma

retinitis vesiculitis

1 disease from the University of Copenhagen DISEASES database for RAP2B:

Platelet storage pool deficiency

Human Genome Epidemiology (HuGE) Navigator: RAP2B (3 documents)

Export disorders for RAP2B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RAP2B gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with RAP2B)

Utopia: connect your pdf to the dynamic
world of online information

RAP2B: a RAS-related GTP-binding protein from platelets. (PubMed id 2118648)^{1, 2, 3} Ohmstede C.A.... Lapetina E.G. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. (PubMed id 11877431)^{1, 2} Evellin S.... Schmidt M. (2002)
Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. (PubMed id 12444546)^{1, 2} Song C.... Kataoka T. (2002)
Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. (PubMed id 8424780)^{1, 2} Farrell F.X.... Lapetina E.G. (1993)
cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2. (PubMed id 2115998)^{1, 2} Farrell F.X.... Lapetina E.G. (1990)
Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3. (PubMed id 15143162)^{2, 9} Stope M.B....Schmidt M. (2004)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5912	HGNC: 9862	AceView: RAP2B	Ensembl:ENSG00000181467	euGenes: HUgn5912
ECgene: RAP2B	H-InvDB: RAP2B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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PharmGKB entry for RAP2B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RAP2B	Genetics and Cytogenetics in Oncology and Haematology

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RAP2B, member of RAS oncogene family

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RAP2B, member of RAS oncogene family

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