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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAP2B Gene

protein-coding   GIFtS: 62
GCID: GC03P152880

RAP2B, Member Of RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAP2B, Member Of RAS Oncogene Family1 2
Ras-Related Protein RAP-2B1 2
Small GTP Binding Protein1 2
Ras Family Small GTP Binding Protein RAP2B1

External Ids:    HGNC: 98621   Entrez Gene: 59122   Ensembl: ENSG000001814677   OMIM: 1795415   UniProtKB: P612253   

Export aliases for RAP2B gene to outside databases

Previous GC identifers: GC03P149859 GC03P153724 GC03P154161 GC03P154201 GC03P154200 GC03P154362 GC03P150272


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAP2B Gene:
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share
approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in
common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine
in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and
palmitoylated. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAP2B Gene: 
RAP2B (RAP2B, member of RAS oncogene family) is a protein-coding gene. Diseases associated with RAP2B include lung squamous cell carcinoma, and vesiculitis, and among its related super-pathways are G-protein signaling G-Protein alpha-i signaling cascades and Rho Family GTPases. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225
Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.
Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal
rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane
vesiculation in red blood cells

Gene Wiki entry for RAP2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAP2B gene promoter:
         AhR   FOXD3   Arnt   FOXL1   CREB   Egr-2   HSF2   deltaCREB   Msx-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAP2B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAP2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.2   Ensembl cytogenetic band:  3q25.2   HGNC cytogenetic band: 3q25.2

RAP2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP2B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P152880:  view genomic region     (about GC identifiers)

Start:
152,880,029 bp from pter      End:
152,886,265 bp from pter
Size:
6,237 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225 (See protein sequence)
Recommended Name: Ras-related protein Rap-2b precursor  
Size: 183 amino acids; 20504 Da
Subunit: Interacts with PLCE1. Interacts with SGSM1, SGSM2 and SGSM3. The GTP-bound form of RAP2B interacts with
RUNDC3A (By similarity)
Subcellular location: Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Associated with red blood
cells-released vesicles
Secondary accessions: P17964 Q96EG5 Q9CXG0

Explore the universe of human proteins at neXtProt for RAP2B: NX_P61225

Explore proteomics data for RAP2B at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK
    (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61225

  • RAP2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAP2B Protein Expression
    REFSEQ proteins: NP_002877.2  
    ENSEMBL proteins: 
     ENSP00000319096  

    Human Recombinant Protein Products for RAP2B: 
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    ProSpec Recombinant Protein for RAP2B
    Cloud-Clone Corp. Proteins for RAP2B 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol IEA--
    GO:0016020membrane ----
    GO:0055037recycling endosome ----
    GO:0055038recycling endosome membrane ISS--

    RAP2B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P61225

    ProtoNet protein and cluster: P61225

    3 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225
    Domain: The effector domain mediates the interaction with RUNDC3A (By similarity)
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RAP2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAP2B_HUMAN, P61225
    Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.
    Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal
    rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane
    vesiculation in red blood cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
    GO:0019904protein domain specific binding IEA--
         
    RAP2B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAP2B:
     Decreased viability of wild-ty  Increased cilium length after   Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAP2B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-protein signaling G-Protein alpha-i signaling cascades
    Development Beta-adrenergic receptors regulation of ERK0.55
    2Rho Family GTPases
    Molecular Mechanisms of Cancer0.51
    3G-protein signaling Rap2B regulation pathway
    G-protein signaling Rap2B regulation pathway1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for RAP2B
        Development Beta-adrenergic receptors regulation of ERK
    G-protein signaling Rap2B regulation pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAP2B
        Molecular Mechanisms of Cancer

    2 GeneGo (Thomson Reuters) Pathways for RAP2B
        G-protein signaling Rap2B regulation pathway
    Development Beta-adrenergic receptors regulation of ERK



    RAP2B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAP2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for RAP2B (P612252, 3 ENSP000003190964) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUNDC3AQ59EK92, 3, ENSP000004108624MINT-67921 I2D: score=5 STRING: ENSP00000410862
    RAPGEF2Q9Y4G83, ENSP000002644314I2D: score=2 STRING: ENSP00000264431
    RALGDSQ129673, ENSP000003611204I2D: score=2 STRING: ENSP00000361120
    RALAP112333, ENSP000000052574I2D: score=1 STRING: ENSP00000005257
    RAPGEF5Q925653, ENSP000003436564I2D: score=1 STRING: ENSP00000343656
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction TAS2118648
    GO:0007264small GTPase mediated signal transduction ----
    GO:0015031protein transport ----
    GO:0030336negative regulation of cell migration IEA--

    RAP2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RAP2B

    1 HMDB Compound for RAP2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RAP2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAP2B gene: 
    NM_002886.3  

    Unigene Cluster for RAP2B:

    RAP2B, member of RAS oncogene family
    Hs.98643  [show with all ESTs]
    Unigene Representative Sequence: NM_002886
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000323534(uc003ezr.3)
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAP2B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP2B

    Additional mRNA sequence: 

    AF493915.1 AL713766.1 BC012362.1 X52987.1 

    7 DOTS entries:

    DT.91782119  DT.456382  DT.95369655  DT.100827522  DT.100758269  DT.101966301  DT.99971147 

    24/154 AceView cDNA sequences (see all 154):

    AI087344 N36816 AI435043 BM692947 AA515514 BF475296 BX492988 AA232794 
    AA490572 BE045429 BQ003160 N24902 AA233853 BF062479 AA429990 AI452392 
    CN480624 AA446252 BF965860 BQ016053 BX283172 AW674886 BF477820 AA496974 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAP2B expression in normal human tissues (normalized intensities)      RAP2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RAP2B Expression
    About this image


    RAP2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             oocyte   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See RAP2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAP2B

    SOURCE GeneReport for Unigene cluster: Hs.98643

    UniProtKB/Swiss-Prot: RAP2B_HUMAN, P61225
    Tissue specificity: Expressed in red blood cells (at protein level)

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAP2B gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap2b1 , 5 RAP2B, member of RAS oncogene family1, 5 93.44(n)1
    100(a)1
      3 (29.81 cM)5
    740121  NM_028712.41  NP_082988.11 
     613645075 
    lizard
    (Anolis carolinensis)
    Reptilia RAP2B6
    Uncharacterized protein
    97(a)
    1 ↔ 1
    3(17061473-17062024)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.13222 Xenopus laevis transcribed sequence with strong similarity more 84.16(n)    BU916667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srnyz1282 Danio rerio cDNA clone MGC55550 IMAGE2642754, complete more 87.59(n)    BC054999.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rap2l1 , 3 RAS small monomeric GTPase3
    Ras-associated protein 2-like1
    67(a)3
    62.09(n)1
    68.13(a)1
      60B73
    378501  NM_058054.31  NP_477402.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C25D7.73 RAS-related protein 60(a)
    (best of 2)
      V(15064493-15066667)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSR16
    GTP-binding protein of the ras superfamily require...
    34(a)
    1 → many
    VII(794674-795492)


    ENSEMBL Gene Tree for RAP2B (if available)
    TreeFam Gene Tree for RAP2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAP2B gene
    RAP2C2  DIRAS12  RAP1B2  RALA2  RIT22  RAP2A2  RIT12  RALB2  
    RAP1A2  NRAS2  DIRAS22  KRAS2  HRAS2  DIRAS32  
    18/103 SIMAP similar genes for RAP2B using alignment to 1 protein entry:     RAP2B_HUMAN(see all similar genes):
    DKFZp547A0616    RAP2A    RAP2C    RAP1B    RIT2    c-bas/has
    RAP1A    RIT1    RALA    DIRAS2    DIRAS1    RRAS2
    RALB    MRAS    RERG    KRAS    NRAS    HRAS

    RAP2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/167 SNPs in RAP2B are shown (see all 167)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875402951,2
    --152878077(+) ACATTA/GGGTGG 1 -- us2k10--------
    rs1420052951,2
    --152878093(+) GACAGG/TGTTCT 1 -- us2k10--------
    rs1442812941,2
    C--152878237(+) CACCAC/TCCACC 1 -- us2k10--------
    rs764849381,2
    C--152878322(+) GGAAGA/CTGCTT 1 -- us2k10--------
    rs1929874171,2
    C--152878393(+) TGAAAA/C/GCGTGT 1 -- us2k10--------
    rs1829787961,2
    --152878586(+) ACAAGA/TCGGGG 1 -- us2k10--------
    rs8948021,2
    C,F,A,H--152878719(-) CCACTT/GGGAAT 1 -- us2k121Minor allele frequency- G:0.23NS EA NA WA CSA 2348
    rs1886642291,2
    --152878742(+) CCTCGC/TCCCCT 1 -- us2k10--------
    rs8948011,2
    C,F,O,H--152878838(-) GTCACG/TACTGC 1 -- us2k123Minor allele frequency- T:0.07NA EA MN NS WA 2774
    rs1412434441,2
    C--152878839(+) CAGTCA/GTGACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAP2B (152880029 - 152886265 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RAP2B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv820284CNV Gain19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179541    OMIM disorders: --

    5 diseases for RAP2B:    About MalaCards
    lung squamous cell carcinoma    vesiculitis    platelet storage pool deficiency    squamous cell carcinoma
    retinitis

    1 disease from the University of Copenhagen DISEASES database for RAP2B:
    Platelet storage pool deficiency

    RAP2B for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAP2B
    Human Genome Epidemiology (HuGE) Navigator: RAP2B (3 documents)

    Export disorders for RAP2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAP2B gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with RAP2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RAP2B: a RAS-related GTP-binding protein from platelets. (PubMed id 2118648)1, 2, 3 Ohmstede C.A.... Lapetina E.G. (1990)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. (PubMed id 11877431)1, 2 Evellin S.... Schmidt M. (2002)
    5. Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. (PubMed id 12444546)1, 2 Song C.... Kataoka T. (2002)
    6. Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. (PubMed id 8424780)1, 2 Farrell F.X.... Lapetina E.G. (1993)
    7. cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2. (PubMed id 2115998)1, 2 Farrell F.X.... Lapetina E.G. (1990)
    8. Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3. (PubMed id 15143162)2, 9 Stope M.B....Schmidt M. (2004)
    9. Rap2b, a novel p53 target, regulates p53-mediated pro- survival function. (PubMed id 23535297)1 Zhang X....Huang J. (2013)
    10. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5912 HGNC: 9862 AceView: RAP2B Ensembl:ENSG00000181467 euGenes: HUgn5912
    ECgene: RAP2B H-InvDB: RAP2B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAP2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP2B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAP2B gene:
    Search GeneIP for patents involving RAP2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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