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Aliases for RAP2A Gene

Aliases for RAP2A Gene

  • RAP2A, Member Of RAS Oncogene Family 2 3
  • RbBP-30 3 4
  • RAP2, Member Of RAS Oncogene Family (K-Rev) 3
  • Ras-Related Protein Rap-2a 3
  • K-Rev 3
  • KREV 3
  • RAP2 3

External Ids for RAP2A Gene

Previous HGNC Symbols for RAP2A Gene

  • RAP2

Previous GeneCards Identifiers for RAP2A Gene

  • GC13P096446
  • GC13P092473
  • GC13P096923
  • GC13P095784
  • GC13P096884
  • GC13P098086
  • GC13P078683

Summaries for RAP2A Gene

GeneCards Summary for RAP2A Gene

RAP2A (RAP2A, Member Of RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAP2A include kuhnt-junius degeneration. Among its related pathways are ERK Signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for RAP2A Gene

  • Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.

Gene Wiki entry for RAP2A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP2A Gene

Genomics for RAP2A Gene

Regulatory Elements for RAP2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAP2A Gene

Start:
97,434,221 bp from pter
End:
97,469,128 bp from pter
Size:
34,908 bases
Orientation:
Plus strand

Genomic View for RAP2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAP2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP2A Gene

Proteins for RAP2A Gene

  • Protein details for RAP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10114-RAP2A_HUMAN
    Recommended name:
    Ras-related protein Rap-2a
    Protein Accession:
    P10114
    Secondary Accessions:
    • B2RCJ1
    • Q5JSC1
    • Q5JSC2

    Protein attributes for RAP2A Gene

    Size:
    183 amino acids
    Molecular mass:
    20615 Da
    Quaternary structure:
    • Interacts (GTP-bound form) with RUNDC3A. Interacts with RGS14; the interaction is GTP-dependent (By similarity). Interacts with PLCE1. Interacts with ARHGAP29, SGSM1, SGSM2 and SGSM3. Interacts (GTP-bound form preferentially) with TNIK (via the CNH domain); the interaction is direct and recruits RAP2A to the E3 ubiquitin ligase NEDD4. Interacts with MINK1. Interacts (GTP-bound form preferentially) with MAP4K4. Interacts with cytoskeletal actin.

    Three dimensional structures from OCA and Proteopedia for RAP2A Gene

neXtProt entry for RAP2A Gene

Proteomics data for RAP2A Gene at MOPED

Post-translational modifications for RAP2A Gene

  • Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK (By similarity).
  • Ubiquitinated; undergoes Lys-63 monoubiquitination and diubiquitination by NEDD4. Multiple lysine residues are probably modified. Ubiquitination requires TNIK, prevents interaction with effectors and inactivates RAP2A.
  • Ubiquitination at Lys5
  • Modification sites at PhosphoSitePlus

Other Protein References for RAP2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAP2A Gene

Domains for RAP2A Gene

Suggested Antigen Peptide Sequences for RAP2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10114

UniProtKB/Swiss-Prot:

RAP2A_HUMAN :
  • P10114
Domain:
  • The effector domain mediates the interaction with RUNDC3A.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RAP2A: view

No data available for Gene Families for RAP2A Gene

Function for RAP2A Gene

Molecular function for RAP2A Gene

GENATLAS Biochemistry:
RAP2A,Ras oncogene superfamily member (K-rev),overexpressed in sporadic breast cancer,grade I
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by the guanine nucleotide-exchange factors RAPGEF3 and RAPGEF4 in a cAMP-dependent manner. Nucleotide exchange is also specifically stimulated by RAPGEF5, RASGEF1A and RASGEF1B.
UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.

Gene Ontology (GO) - Molecular Function for RAP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 1900290
GO:0005515 protein binding IPI 14966141
GO:0005525 GTP binding IDA 22797597
genes like me logo Genes that share ontologies with RAP2A: view

Phenotypes for RAP2A Gene

GenomeRNAi human phenotypes for RAP2A:
genes like me logo Genes that share phenotypes with RAP2A: view

Animal Model Products

miRNA for RAP2A Gene

miRTarBase miRNAs that target RAP2A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAP2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAP2A Gene

Localization for RAP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP2A Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995). Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443). {ECO:0000269 PubMed:23894443, ECO:0000269 PubMed:7962206, ECO:0000269 PubMed:8391995}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAP2A Gene COMPARTMENTS Subcellular localization image for RAP2A gene
Compartment Confidence
endosome 5
cytosol 3
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA 22797597
GO:0016020 membrane --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with RAP2A: view

Pathways for RAP2A Gene

genes like me logo Genes that share pathways with RAP2A: view

Pathways by source for RAP2A Gene

2 Qiagen pathways for RAP2A Gene
1 BioSystems pathway for RAP2A Gene
1 GeneGo (Thomson Reuters) pathway for RAP2A Gene

Gene Ontology (GO) - Biological Process for RAP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 22797597
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAP2A: view

Compounds for RAP2A Gene

(2) HMDB Compounds for RAP2A Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Drugbank Compounds for RAP2A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Diphosphate
146-91-8 target
Guanosine-5'-Triphosphate
86-01-1 target

(3) Novoseek inferred chemical compound relationships for RAP2A Gene

Compound -log(P) Hits PubMed IDs
cyclic amp 55.7 4
gtp 42.9 3
glutamine 16.9 1
genes like me logo Genes that share compounds with RAP2A: view

Transcripts for RAP2A Gene

mRNA/cDNA for RAP2A Gene

Unigene Clusters for RAP2A Gene

RAP2A, member of RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAP2A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAP2A Gene

No ASD Table

Relevant External Links for RAP2A Gene

GeneLoc Exon Structure for
RAP2A
ECgene alternative splicing isoforms for
RAP2A

Expression for RAP2A Gene

mRNA expression in normal human tissues for RAP2A Gene

Protein differential expression in normal tissues for RAP2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.8), Brain (15.7), and Frontal cortex (10.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAP2A Gene

SOURCE GeneReport for Unigene cluster for RAP2A Gene Hs.508480

genes like me logo Genes that share expressions with RAP2A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for RAP2A Gene

Orthologs for RAP2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAP2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAP2A 35
  • 93.26 (n)
  • 99.45 (a)
RAP2A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAP2A 35
  • 94.9 (n)
  • 96.47 (a)
RAP2A 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rap2a 35
  • 94.35 (n)
  • 99.45 (a)
Rap2a 16
Rap2a 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAP2A 35
  • 99.82 (n)
  • 99.45 (a)
RAP2A 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAP2A 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAP2A 35
  • 89.62 (n)
  • 98.36 (a)
RAP2A 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAP2A 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rap2a 35
  • 83.06 (n)
  • 98.36 (a)
zebrafish
(Danio rerio)
Actinopterygii rap2ab 35
  • 85.25 (n)
  • 95.08 (a)
CABZ01067868.1 36
  • 97 (a)
OneToMany
rap2ab 36
  • 95 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9348 35
fruit fly
(Drosophila melanogaster)
Insecta Rap2l 37
  • 69 (a)
Rap2l 36
  • 69 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C08F8.7 37
  • 48 (a)
C25D7.7 37
  • 59 (a)
rap-2 35
  • 63.48 (n)
  • 70.79 (a)
rap-2 36
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 36
  • 35 (a)
OneToMany
Species with no ortholog for RAP2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP2A Gene

ENSEMBL:
Gene Tree for RAP2A (if available)
TreeFam:
Gene Tree for RAP2A (if available)

Paralogs for RAP2A Gene

genes like me logo Genes that share paralogs with RAP2A: view

Variants for RAP2A Gene

Sequence variations from dbSNP and Humsavar for RAP2A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs15358 -- 97,466,120(-) taaaa(A/G)aaaaa utr-variant-3-prime
rs1055959 -- 97,437,414(+) GTTTC(A/C)TTATC intron-variant
rs1127349 -- 97,466,950(+) CACTT(A/T)AGGAA utr-variant-3-prime
rs1159277 -- 97,433,070(+) CGAAG(A/G)GCCCC upstream-variant-2KB
rs1159278 -- 97,433,095(+) TGGGA(A/G)GTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAP2A Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv832694 CNV Gain 17160897
esv21981 CNV Loss 19812545
esv2664226 CNV Deletion 23128226
esv21921 CNV Loss 19812545
esv2747855 CNV Deletion 23290073

Relevant External Links for RAP2A Gene

HapMap Linkage Disequilibrium report
RAP2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAP2A Gene

Disorders for RAP2A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RAP2A Gene in MalaCards »

(1) Diseases for RAP2A Gene including...

(2) University of Copenhagen DISEASES for RAP2A Gene

Relevant External Links for RAP2A

Genetic Association Database (GAD)
RAP2A
Tumor Gene Database (TGDB):
RAP2A
genes like me logo Genes that share disorders with RAP2A: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for RAP2A Gene

Publications for RAP2A Gene

  1. Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. (PMID: 8424780) Farrell F.X. … Lapetina E.G. (Biochem. J. 1993) 3 4 23
  2. Structure of the small G protein Rap2 in a non-catalytic complex with GTP. (PMID: 10591105) Menetrey J. … Cherfils J. (Proteins 1999) 3 4 23
  3. Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. (PMID: 14966141) Machida N. … Kariya K. (J. Biol. Chem. 2004) 3 4 23
  4. Biochemical characterization of RGS14: RGS14 activity towards G- protein alpha subunits is independent of its binding to Rap2A. (PMID: 16246175) Mittal V. … Linder M.E. (Biochem. J. 2006) 3 4 23
  5. Rap2 function requires palmitoylation and recycling endosome localization. (PMID: 19061864) Uechi Y. … Kariya K. (Biochem. Biophys. Res. Commun. 2009) 3 4 23

Products for RAP2A Gene

  • Addgene plasmids for RAP2A

Sources for RAP2A Gene

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