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Aliases & Descriptions for RAP2A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| K-REV 1, 2 | | KREV 2 | | OTTHUMP00000018581 2 | | RAP2 2 | | RbBP-30 2, 3 |
| | | Descriptions |
|---|
| RAP2, member of RAS oncogene family (K-rev) 2 | | RAP2A, member of RAS oncogene family 2 |
|
| | Search outside databases for aliases for RAP2A genePrevious GC identifers: GC13P096446 GC13P092473 GC13P096923 GC13P095784 |
Summaries for RAP2A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Location for RAP2A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAP2A gene 
Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q32.1 HGNC cytogenetic band: 13q34RAP2A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P096884:
(about GC identifiers)
Start:
|
96,884,475 bp from pter |
End:
|
96,918,245 bp from pter |
Size:
|
33,771 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000013.9 NT_009952.14
| Proteins for RAP2A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAP2A_HUMAN, P10114 (See
protein sequence)Recommended Name: Ras-related protein Rap-2a precursor Size: 183 amino acids; 20615 Da
Subunit: Interacts with PLCE1. Interacts with SGSM1, SGSM2, SGSM3 and ARHGAP29. The GTP-bound form of RAP2A interacts with RUNDC3A (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :1KAO (3D)
 2RAP (3D)
 3RAP (3D)
 
Secondary accessions: Q5JSC1 Q5JSC2REFSEQ proteins: NP_066361.1
ENSEMBL proteins: ENSP00000245304
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAP2A 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- | | GO:0005886 | plasma membrane |
IEA | -- | About this table
Antibodies for RAP2A: Assays for RAP2A: | Protein
Domains/ Families for RAP2A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P10114
ProtoNet protein and cluster: P10114 2 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB003577 Ras small GTPase
UniProtKB/Swiss-Prot: RAP2A_HUMAN, P10114Domain: The effector domain mediates the interaction with RUNDC3A (By similarity)Similarity: Belongs to the small GTPase superfamily. Ras family | Gene Function for RAP2A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021033
Applied Biosystems Silencer® siRNAs for RAP2A
Sigma-Aldrich siRNA for RAP2A  Sigma-Aldrich shRNA for RAP2A  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021033                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021033                                  untagged cDNA clone in CMV expression vector: NM_021033 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_021033
UniProtKB/Swiss-Prot: RAP2A_HUMAN, P10114Enzyme regulation: Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFRGenatlas biochemistry entry for RAP2A:RAP2A,Ras oncogene superfamily member (K-rev),overexpressed in sporadic breast cancer,grade I4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAP2A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Sigma-Aldrich "Your Favorite Gene" Pathways for RAP2A (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for RAP2A 
5/28 Interacting proteins for RAP2A (P101141 ENSP000002453043) via UniProtKB, MINT, and/or STRING (see all 28
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
TAS | 3045729 | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | About this table
|
Drugs & Compounds for RAP2A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAP2A |
Browse Tocris compounds for RAP2A 2 Novoseek chemical compound relationships for RAP2A gene
About this table
|
Transcripts for RAP2A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021033
Sigma-Aldrich siRNA for RAP2A  Sigma-Aldrich shRNA for RAP2A  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_021033 REFSEQ mRNAs for RAP2A gene: NM_021033.6
Applied Biosystems TaqMan ® Gene Expression Assays: NM_021033               OriGene GFP tagged cDNA clone in CMV expression vector: NM_021033                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021033                                  untagged cDNA clone in CMV expression vector: NM_021033  Additional cDNA sequence: AF205602.1 AF493914.1 AK090533.1 AK094586.1 AK311202.1 AK315139.1 BC022356.1 BC041333.2 BC047495.1 BC070031.1 X12534.1 8 DOTS entries: DT.454556 DT.100791300 DT.120779971 DT.40113077 DT.97844836 DT.102830970 DT.95156522 DT.100791299 24/292 AceView cDNA sequences (see all 292
):AI304350 F13073 BQ027312 AA767216 BF198130 BM705964 X12534 AI401270 AI417253 T10769 AA171989 BE503099 AI288777 AI299553 T16259 AW271400 AA488116 AI302106 AI288778 AW139422 BF198095 AI422246 AW078643 BQ007743
highest scoring ESTs for RAP2A:AI963476 X12534 AA007240 AA007241 AA084123 AA084155 AA122214 AA122215 AA171989 AA172305 Unigene Cluster for RAP2A: RAP2A, member of RAS oncogene family Hs.508480 [show with all ESTs]Unigene Representative Sequence: BC041333
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000245304
|
Expression for RAP2A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAP2A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAP2A
1 / 2 / 3 11 probe-sets matching RAP2A gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AATTGTAGTT
SOURCE GeneReport for Unigene cluster: Hs.508480
Expression variation in blood from EXPOLDB for RAP2A |
Orthologs for RAP2A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAP2A gene from 5/11 species (see all 11
)
About this table Species with no ortholog for RAP2A
ENSEMBL Gene Tree for RAP2A | Paralogs for RAP2A(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAP2A gene
- RAP2C2 RAP2B2
|
SNPs/Variants for RAP2A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAP2A (up to first 250kb)
|
Disorders & Mutations for RAP2A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 179540
Tumor Gene Database: RAP2A
|
Medical News for RAP2A(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAP2A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/55 PubMed articles for RAP2A gene (see all 55
):- Structure of the small G protein Rap2 in a non-catalytic complex with GTP. (PubMed id 10591105)1, 3, 4 Menetrey J. and Cherfils J. (1999)
- Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. (PubMed id 8424780)1, 3, 4 Farrell F.X.... Lapetina E.G. (1993)
- PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector. (PubMed id 15752761)3, 4 Myagmar B.-E.... Kariya K. (2005)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)3, 4 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. (PubMed id 12444546)3, 4 Song C.... Kataoka T. (2002)
- Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS. (PubMed id 9312017)3, 4 Cherfils J.... Auzat I. (1997)
- The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis. (PubMed id 1900290)3, 4 Lerosey I.... Tavitian A. (1991)
- Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. (PubMed id 3045729)3, 4 Pizon V.... Tavitian A. (1988)
- Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. (PubMed id 14966141)1, 3 Machida N....Kariya K. (2004)
|
Search for RAP2A
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAP2A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAP2A
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAP2A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAP2A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAP2A:

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Incremental update: 13 Oct 2009
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