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RAP2A Gene

protein-coding   GIFtS: 67
GCID: GC13P098086

RAP2A, Member Of RAS Oncogene Family


(Previous symbol: RAP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAP2A, Member Of RAS Oncogene Family1 2     KREV2
RAP21 2     RAP2, Member Of RAS Oncogene Family (K-Rev)2
RbBP-302 3     Ras-Related Protein Rap-2a2
K-REV2     

External Ids:    HGNC: 98611   Entrez Gene: 59112   Ensembl: ENSG000001252497   OMIM: 1795405   UniProtKB: P101143   

Export aliases for RAP2A gene to outside databases

Previous GC identifers: GC13P096446 GC13P092473 GC13P096923 GC13P095784 GC13P096884 GC13P078683


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RAP2A Gene:
RAP2A (RAP2A, member of RAS oncogene family) is a protein-coding gene. Diseases associated with RAP2A include kuhnt-junius degeneration, and vesiculitis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RAP2A_HUMAN, P10114
Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its
active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling
complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during
development. More generally, it is part of several signaling cascades and may regulate cytoskeletal
rearrangements, cell migration, cell adhesion and cell spreading

Gene Wiki entry for RAP2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_009952.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAP2A gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   TBP   oct-B2   oct-B3   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): RAP2A promoter sequence
   Search Chromatin IP Primers for RAP2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAP2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q34

RAP2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP2A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P098086:  view genomic region     (about GC identifiers)

Start:
98,086,475 bp from pter      End:
98,121,382 bp from pter
Size:
34,908 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RAP2A_HUMAN, P10114 (See protein sequence)
Recommended Name: Ras-related protein Rap-2a precursor  
Size: 183 amino acids; 20615 Da
Subunit: Interacts (GTP-bound form) with RUNDC3A. Interacts with RGS14; the interaction is GTP-dependent (By
similarity). Interacts with PLCE1. Interacts with ARHGAP29, SGSM1, SGSM2 and SGSM3. Interacts (GTP-bound form
preferentially) with TNIK (via the CNH domain); the interaction is direct and recruits RAP2A to the E3 ubiquitin
ligase NEDD4. Interacts with MINK1. Interacts (GTP-bound form preferentially) with MAP4K4. Interacts with
cytoskeletal actin
3 PDB 3D structures from and Proteopedia for RAP2A:
1KAO (3D)        2RAP (3D)        3RAP (3D)    
Secondary accessions: B2RCJ1 Q5JSC1 Q5JSC2

Explore the universe of human proteins at neXtProt for RAP2A: NX_P10114

Explore proteomics data for RAP2A at MOPED

Post-translational modifications: 

  • Ubiquitinated; undergoes 'Lys-63' monoubiquitination and diubiquitination by NEDD4. Multiple lysine residues are
    probably modified. Ubiquitination requires TNIK, prevents interaction with effectors and inactivates RAP2A1
  • Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK
    (By similarity)1
  • Ubiquitination2 at Lys5
  • Modification sites at PhosphoSitePlus

  • See RAP2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066361.1  
    ENSEMBL proteins: 
     ENSP00000245304   ENSP00000436462  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P10114

    ProtoNet protein and cluster: P10114

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RAP2A_HUMAN, P10114
    Domain: The effector domain mediates the interaction with RUNDC3A (By similarity)
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RAP2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAP2A_HUMAN, P10114
    Function: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its
    active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling
    complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during
    development. More generally, it is part of several signaling cascades and may regulate cytoskeletal
    rearrangements, cell migration, cell adhesion and cell spreading
    Enzyme regulation: Activated by the guanine nucleotide-exchange factors RAPGEF3 and RAPGEF4 in a cAMP-dependent
    manner. Nucleotide exchange is also specifically stimulated by RAPGEF5, RASGEF1A and RASGEF1B

         Genatlas biochemistry entry for RAP2A:
    RAP2A,Ras oncogene superfamily member (K-rev),overexpressed in sporadic breast cancer,grade I

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA1900290
    GO:0005515protein binding IPI14966141
    GO:0005525GTP binding IEA--
         
    RAP2A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAP2A:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAP2A
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAP2A

    miRNA
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    miRTarBase miRNAs that target RAP2A:
    hsa-mir-34a-5p (MIRT047381)

    Block miRNA regulation of human, mouse, rat RAP2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAP2A (see all 37):
    hsa-miR-330-5p hsa-miR-199a-3p hsa-miR-938 hsa-miR-508-3p hsa-miR-223 hsa-miR-4314 hsa-miR-9 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidRAP2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAP2A
    Predesigned siRNA for gene silencing in human, mouse, rat RAP2A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: RAP2A (NM_021033)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP2A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAP2A_HUMAN, P10114: Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=May also localize
    to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995). Colocalizes
    with RASGEF1B to midbody at telophase (PubMed:23894443)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol IEA--
    GO:0016020membrane ----
    GO:0030496midbody IEA--
    GO:0055037recycling endosome IDA19061864

    RAP2A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAP2A About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    2ERK Signaling
    Molecular Mechanisms of Cancer0.51
    3G Protein Signaling Pathways
    Signal transduction cAMP signaling0.44
    4B Cell Receptor Signaling Pathway (WikiPathways)
    B Cell Receptor Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAP2A
        Molecular Mechanisms of Cancer
    cAMP Pathway

    1 GeneGo (Thomson Reuters) Pathway for RAP2A
        Signal transduction cAMP signaling

    1 BioSystems Pathway for RAP2A
        B Cell Receptor Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAP2A
    Interactions:

        GeneGlobe Interaction Network for RAP2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAP2A (P101143 ENSP000002453044) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    GRIN1Q055863, ENSP000003606164I2D: score=3 STRING: ENSP00000360616
    RAPGEF5Q925653, ENSP000003436564I2D: score=3 STRING: ENSP00000343656
    RGS14O435663, ENSP000003862294I2D: score=3 STRING: ENSP00000386229
    RUNDC3AQ59EK93, ENSP000004108624I2D: score=3 STRING: ENSP00000410862
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----

    RAP2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAP2A

    2 HMDB Compounds for RAP2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for RAP2A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423
    Guanosine-5'-Triphosphate-- 86-01-1target--17139284 17016423

    3 Novoseek inferred chemical compound relationships for RAP2A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 55.7 8 18391018 (1), 16452984 (1), 14506476 (1), 19788733 (1)
    gtp 42.9 3 10591105 (1), 9523700 (1), 17300802 (1)
    glutamine 16.9 1 17300802 (1)



    RAP2A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RAP2A gene: 
    NM_021033.6  

    Unigene Cluster for RAP2A:

    RAP2A, member of RAS oncogene family
    Hs.508480  [show with all ESTs]
    Unigene Representative Sequence: BC041333
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000245304(uc001vnd.3) ENST00000476869
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RAP2A (see all 37):
    hsa-miR-330-5p hsa-miR-199a-3p hsa-miR-938 hsa-miR-508-3p hsa-miR-223 hsa-miR-4314 hsa-miR-9 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidRAP2A 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RAP2A
      QuantiFast Probe-based Assays in human, mouse, rat RAP2A

    Additional mRNA sequence: 

    AF205602.1 AF493914.1 AK090533.1 AK094586.1 AK311202.1 AK315139.1 BC022356.1 BC041333.2 
    BC047495.1 BC070031.1 X12534.1 

    9 DOTS entries:

    DT.454556  DT.100791300  DT.120779971  DT.40113077  DT.97844836  DT.95156522  DT.102830970  DT.100791299 
    DT.422833 

    Selected AceView cDNA sequences (see all 292):

    BF197987 AI347098 BQ002172 T16790 BF197991 BQ007743 AI384001 AI073762 
    AW949348 BF110282 T10769 CB565908 AF493914 AI299553 AI304350 AI000075 
    AI375326 BE503099 AA294987 AI340368 H18830 AI129727 BX505275 AI401270 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAP2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTGTAGTT
    RAP2A Expression
    About this image

    RAP2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAP2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508480
        Custom PCR Arrays for RAP2A
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RAP2A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAP2A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap2a1 , 5 RAS related protein 2a1, 5 94.35(n)1
    99.45(a)1
      14 (64.72 cM)5
    761081  NM_029519.31  NP_083795.21 
     1205036015 
    chicken
    (Gallus gallus)
    Aves RAP2A1 RAP2A, member of RAS oncogene family 89.62(n)
    98.36(a)
      769797  XM_001233103.2  XP_001233104.2 
    lizard
    (Anolis carolinensis)
    Reptilia RAP2A6
    RAP2A, member of RAS oncogene family
    98(a)
    1 ↔ 1
    3(86073088-86099100)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU909619.12   -- 83.77(n)    BU909619.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rap2ab1 RAP2A, member of RAS oncogene family b 85.25(n)
    95.08(a)
      100003903  NM_001145705.1  NP_001139177.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rap2l3 RAS small monomeric GTPase 69(a)   60B7   --
    worm
    (Caenorhabditis elegans)
    Secernentea C25D7.73
    rap-21
    RAS-related protein3
    rap-21
    59(a)
    (best of 2)3
    63.48(n)1
    70.79(a)1
      V(15064493-15066667)3
    1800111  NM_074306.21  NP_506707.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSR16
    GTP-binding protein of the ras superfamily require...
    35(a)
    1 → many
    VII(794674-795492) YGR152C


    ENSEMBL Gene Tree for RAP2A (if available)
    TreeFam Gene Tree for RAP2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAP2A gene
    RAP2C2  RASL10B2  DIRAS12  RAP1B2  RASD22  RIT22  RIT12  RAP1A2  
    RAP2B2  RASD12  DIRAS22  RASL10A2  DIRAS32  
    Selected SIMAP similar genes for RAP2A using alignment to 2 protein entries:     RAP2A_HUMAN (see all proteins) (see all similar genes):
    RAP2C    DKFZp547A0616    RAP2B    RAP1B    H-RAS    K-RAS
    N-ras    KRAS    RAP1A    c-bas/has    RIT2    NRAS
    RIT1    DIRAS2    DIRAS1    HRAS    RALA    RRAS2

    RAP2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAP2A (see all 598)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741050761,2
    C--98084479(+) CAAATA/GTAAGT 1 -- us2k12Minor allele frequency- G:0.21WA 120
    rs741050781,2
    C,F--98084485(+) TAAGTC/TATCCA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs741050791,2
    C,F--98084499(+) TAATAT/AAACGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1470885621,2
    --98084592(+) ACCTGA/GCTTTT 1 -- us2k10--------
    rs95845751,2
    C,F,A,H--98084675(+) AACAAC/TAGAAC 1 -- us2k115Minor allele frequency- T:0.05NS EA NA WA 1888
    rs1385163431,2
    --98084692(+) AACGTA/GTTATT 1 -- us2k10--------
    rs1164118681,2
    C,F--98084699(+) TATTCG/ACAGGA 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1823365051,2
    --98084791(+) CAAAAA/TATAAT 1 -- us2k10--------
    rs1507055731,2
    --98084852(+) GAGAGA/GATGTG 1 -- us2k10--------
    rs1156852221,2
    C,F--98084960(+) TGCAAC/TTGCTG 1 -- us2k11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for RAP2A (98086475 - 98121382 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RAP2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747855CNV Deletion23290073
    esv2664226CNV Deletion23128226
    esv21981CNV Loss19812545
    esv21921CNV Loss19812545
    nsv832694CNV Gain17160897
    nsv7246OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAP2A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179540    OMIM disorders: --

    10 diseases for RAP2A:    
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    kuhnt-junius degeneration    vesiculitis    sporadic breast cancer    age related macular degeneration
    retinitis    endotheliitis    breast cancer    prostate cancer
    prostatitis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for RAP2A:
    Kuhnt-Junius degeneration     Age related macular degeneration

    RAP2A for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAP2A
    Tumor Gene Database (TGDB): RAP2A

    Export disorders for RAP2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAP2A gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with RAP2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. (PubMed id 14966141)1, 2, 9 Machida N.... Kariya K. (J. Biol. Chem. 2004)
    2. Rap2 function requires palmitoylation and recycling endosome localization. (PubMed id 19061864)1, 2, 9 Uechi Y.... Kariya K. (Biochem. Biophys. Res. Commun. 2009)
    3. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2- specific nucleotide exchange. (PubMed id 19645719)1, 2, 9 Yaman E.... Tazebay U.H. (FEBS J. 2009)
    4. Structure of the small G protein Rap2 in a non-catalytic complex with GTP. (PubMed id 10591105)1, 2, 9 Menetrey J. and Cherfils J. (Proteins 1999)
    5. Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. (PubMed id 8424780)1, 2, 9 Farrell F.X.... Lapetina E.G. (Biochem. J. 1993)
    6. Biochemical characterization of RGS14: RGS14 activity towards G- protein alpha subunits is independent of its binding to Rap2A. (PubMed id 16246175)1, 2, 9 Mittal V. and Linder M.E. (Biochem. J. 2006)
    7. Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. (PubMed id 20159449)1, 2 Kawabe H.... Brose N. (Neuron 2010)
    8. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. (PubMed id 18930710)1, 2 Nonaka H....Kariya K. (Biochem. Biophys. Res. Commun. 2008)
    9. Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation. (PubMed id 16540189)1, 2 Greco F.... Torti M. (Biochim. Biophys. Acta 2006)
    10. PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector. (PubMed id 15752761)1, 2 Myagmar B.-E.... Kariya K. (Biochem. Biophys. Res. Commun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5911 HGNC: 9861 AceView: RAP2A Ensembl:ENSG00000125249 euGenes: HUgn5911
    ECgene: RAP2A H-InvDB: RAP2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAP2A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP2A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAP2A gene:
    Search GeneIP for patents involving RAP2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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