RAP2A Gene

Aliases
for RAP2A gene

Previous GC identifers: GC13P096446 GC13P092473 GC13P096923 GC13P095784 GC13P096884 GC13P078683

Summaries
for RAP2A gene

Genomic Views
for RAP2A gene

RefSeq DNA sequence:

NC_000013.10  NC_018924.1  NT_009952.14  

SwitchGear Promoter luciferase reporter plasmids (see all 4): RAP2A promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP2A

RAP2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P098086:  view genomic region     (about GC identifiers)

Proteins
for RAP2A gene

3 PDB 3D structures from and Proteopedia for RAP2A:

1KAO (3D)        2RAP (3D)        3RAP (3D)    

Explore the universe of human proteins at neXtProt for RAP2A: NX_P10114

Post-translational modifications:

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	OriGene Purified Protein: RAP2A OriGene Protein Over-expression Lysate: RAP2A OriGene Custom Protein Services for RAP2A
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	Novus Biologicals RAP2A Proteins Novus Biologicals RAP2A Lysate
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	ProSpec Recombinant Protein for RAP2A
	Uscn Proteins for RAP2A

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

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	R&D Systems Antibodies for RAP2A
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	Novus Biologicals RAP2A Antibodies
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	Uscn Antibodies for RAP2A
	ThermoFisher Antibodies for RAP2A

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RAP2A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RAP2A

Protein Domains /
Families
for RAP2A gene

ProtoNet protein and cluster: P10114

Function
for RAP2A gene

miRNA Products:		OriGene 3'-UTR Clone: RAP2A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAP2A
		8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate RAP2A (see all 37):
		hsa-miR-330-5p hsa-miR-199a-3p hsa-miR-938 hsa-miR-508-3p hsa-miR-223 hsa-miR-4314 hsa-miR-9 hsa-miR-124
		SwitchGear 3'UTR luciferase reporter plasmid: RAP2A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAP2A (see all 4) OriGene shRNA RFP: RAP2A OriGene siRNA: RAP2A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAP2A

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RAP2A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAP2A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAP2A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RAP2A (NM_021033)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP2A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RAP2A
		Search LifeMap BioReagents cell lines for RAP2A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2A

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for RAP2A gene

	Super-pathway	contained gene-specific pathways
1	G Protein Signaling Pathways	Signal transduction cAMP signaling 0.44 Signal transduction_cAMP signaling 0.44
2	B Cell Receptor Signaling Pathway	B Cell Receptor Signaling Pathway 1.00
3	Activation of cAMP-Dependent PKA	cAMP Pathway 0.77
4	Rho Family GTPases	Molecular Mechanisms of Cancer 0.51

1 EMD Millipore Pathway for RAP2A

Signal transduction cAMP signaling

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAP2A

	Molecular Mechanisms of Cancer
	cAMP Pathway

1 GeneGo (Thomson Reuters) Pathway for RAP2A

Signal transduction cAMP signaling

1 BioSystems Pathway for RAP2A

B Cell Receptor Signaling Pathway

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

Drugs & Compounds
for RAP2A gene

Transcripts
for RAP2A gene

Expression
for RAP2A gene

RAP2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTGTAGTT

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Definitive endoderm-like cells (A scalable, suspensi...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAP2A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAP2A
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP2A

Orthologs
for RAP2A gene

Paralogs
for RAP2A gene

Paralogs for RAP2A gene

RAP2C²  RASL10B²  DIRAS1²  RAP1B²  RASD2²  RAP1A²  RAP2B²  RASD1²  

DIRAS2²  RASL10A²  DIRAS3²  

18/119 SIMAP similar genes for RAP2A using alignment to 2 protein entries:     RAP2A_HUMAN (see all proteins) (see all similar genes):

RAP2C    DKFZp547A0616    RAP2B    RAP1B    KRAS    H-RAS

K-RAS    N-ras    RAP1A    c-bas/has    RIT2    NRAS

RIT1    DIRAS2    DIRAS1    HRAS    RALA    RRAS2

RAP2A for paralogs           About GeneDecksing

Genomic Variants
for RAP2A gene

10/513 NCBI SNPs in RAP2A are shown (see all 513)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs741050761,2	C,	--	98084479(+)	CAAATA/GTAAGT	1	--	us2k1		2		WA	120
rs741050781,2	C,	--	98084485(+)	TAAGTC/TATCCA	1	--	us2k1		1		WA	2
rs741050791,2	C,	--	98084499(+)	TAATAT/AAACGA	1	--	us2k1		1		WA	2
rs1470885621,2		--	98084592(+)	ACCTGA/GCTTTT	1	--	us2k1		0	--	--	--	--
rs95845751,2	C,F,A,H,	--	98084675(+)	AACAAC/TAGAAC	1	--	us2k1		15		NS EA NA WA	1888
rs1385163431,2		--	98084692(+)	AACGTA/GTTATT	1	--	us2k1		0	--	--	--	--
rs1164118681,2	C,F,	--	98084699(+)	TATTCG/ACAGGA	1	--	us2k1		1		WA	118
rs1823365051,2		--	98084791(+)	CAAAAA/TATAAT	1	--	us2k1		0	--	--	--	--
rs1507055731,2		--	98084852(+)	GAGAGA/GATGTG	1	--	us2k1		0	--	--	--	--
rs1156852221,2	C,F,	--	98084960(+)	TGCAAC/TTGCTG	1	--	us2k1		1		WA	118

HapMap Linkage Disequilibrium report for RAP2A (98086475 - 98120252 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for RAP2A
     3 CNVs: 71763 86983 66525
     1 Indel: 71762

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAP2A

DNA2.0 Custom Variant and Variant Library Synthesis for RAP2A

Disorders / Diseases
for RAP2A gene

Publications
for RAP2A gene

PubMed articles for RAP2A gene, integrated from 9 sources (see all 71): (articles sorted by number of sources associating them with RAP2A)

Utopia: connect your pdf to the dynamic world of online information

1. Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. (PubMed id 14966141)^{1, 2, 9} Machida N....Kariya K. (2004)
2. Rap2 function requires palmitoylation and recycling endosome localization. (PubMed id 19061864)^{1, 2, 9} Uechi Y....Kariya K. (2009)
3. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-sp ecific nucleotide exchange. (PubMed id 19645719)^{1, 2, 9} Yaman E....Tazebay U.H. (2009)
4. Structure of the small G protein Rap2 in a non-catalytic complex with GTP. (PubMed id 10591105)^{1, 2, 9} Menetrey J. and Cherfils J. (1999)
5. Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. (PubMed id 8424780)^{1, 2, 9} Farrell F.X.... Lapetina E.G. (1993)
6. Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A. (PubMed id 16246175)^{1, 2, 9} Mittal V. and Linder M.E. (2006)
7. Regulation of Rap2A by the ubiquitin ligase Nedd4-1 c ontrols neurite development. (PubMed id 20159449)^{1, 2} Kawabe H....Brose N. (2010)
8. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. (PubMed id 18930710)^{1, 2} Nonaka H....Kariya K. (2008)
9. Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation. (PubMed id 16540189)^{1, 2} Greco F....Torti M. (2006)
10. PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector. (PubMed id 15752761)^{1, 2} Myagmar B.-E.... Kariya K. (2005)

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Products
for RAP2A gene