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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAP1GDS1 Gene

protein-coding   GIFtS: 60
GCID: GC04P099182

RAP1, GTP-GDP dissociation stimulator 1
 Explore 9 diseases affiliated with
RAP1GDS1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAP1GDS1    

Aliases
for RAP1GDS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAP1, GTP-GDP Dissociation Stimulator 11 2     SMG P21 Stimulatory GDP/GTP Exchange Protein2 3
SmgGDS1 2     GDS12
Exchange Factor SmgGDS2 3     Rap1 GTPase-GDP Dissociation Stimulator 12
SMG GDS Protein2 3     

External Ids:    HGNC: 98591   Entrez Gene: 59102   Ensembl: ENSG000001386987   OMIM: 1795025   UniProtKB: P523063   

Export aliases for RAP1GDS1 gene to outside databases

Previous GC identifers: GC04P099428 GC04P099575 GC04P099641 GC04P099539 GC04P094951


Summaries
for RAP1GDS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAP1GDS1:
The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity
(Riess et al., 1993 (PubMed 8262526)).(supplied by OMIM, Feb 2010)

UniProtKB/Swiss-Prot: GDS1_HUMAN, P52306
Function: Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including
Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to
each small G protein

Gene Wiki entry for RAP1GDS1


Genomic Views
for RAP1GDS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAP1GDS1 gene promoter:
         Oct-B1   TBP   oct-B3   oct-B2   AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   S8   POU2F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAP1GDS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAP1GDS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP1GDS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23-q25   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23-q25

RAP1GDS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP1GDS1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P099182:  view genomic region     (about GC identifiers)

Start:
 99,182,527 bp from pter      End:
 99,365,012 bp from pter
Size:
 182,486 bases      Orientation:
 plus strand

Proteins
for RAP1GDS1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GDS1_HUMAN, P52306 (See protein sequence)
Recommended Name: Rap1 GTPase-GDP dissociation stimulator 1  
Size: 607 amino acids; 66317 Da
Secondary accessions: G5E9P9 Q499L7 Q4KMV2 Q9BUW9 Q9BUX6 Q9NYM2 Q9NZA8
Alternative splicing: 4 isoforms:  P52306-1   P52306-2   P52306-3   P52306-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAP1GDS1: NX_P52306

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52306

    • RAP1GDS1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001093896.1  NP_001093897.1  NP_001093898.1  NP_001093899.1  NP_001093900.1  NP_066982.3  

    ENSEMBL proteins: 
     ENSP00000425992   ENSP00000422348   ENSP00000369503   ENSP00000422426   ENSP00000264572  
     ENSP00000426096   ENSP00000386153   ENSP00000424824   ENSP00000424324   ENSP00000407157  
     ENSP00000426867   ENSP00000424250   ENSP00000421599   ENSP00000386223   ENSP00000340454  
     ENSP00000424239   ENSP00000421482  

    Human Recombinant Protein Products: 
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    Uscn Proteins for RAP1GDS1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    RAP1GDS1 for ontologies           About GeneDecksing



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    Uscn Antibodies for RAP1GDS1
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    Uscn ELISAs and CLIAs for RAP1GDS1

    Protein Domains /
    Families
    for RAP1GDS1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAP1GDS1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P52306

    ProtoNet protein and cluster: P52306

    1 Blocks protein family: IPB000225 Armadillo repeat

    UniProtKB/Swiss-Prot: GDS1_HUMAN, P52306
    Similarity: Contains 5 ARM repeats


    Function
    for RAP1GDS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GDS1_HUMAN, P52306
    Function: Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including
    Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to
    each small G protein

         Genatlas biochemistry entry for RAP1GDS1:
    guanine dinucleotide phosphate stimulating factor of Ras related Rho,Rac proteins,fused with NUP98 in T cell acute
    lymphocytic leukemia with translocation t(4;11)(q21;q25),in a chimeric protein 5' - NUP78 - RAP1GD1 - 3'

    miRNA
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    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate RAP1GDS1 (see all 41):
    hsa-miR-194* hsa-miR-607 hsa-miR-300 hsa-miR-29a hsa-miR-4305 hsa-miR-624* hsa-miR-449a hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmid: RAP1GDS1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity NAS1549351


    RAP1GDS1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for RAP1GDS1:
     Actin fiber cells  Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

    Animal Models:
         1 MGI phenotypic allele for Rap1gds1 (no phenotypes)

    RAP1GDS1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAP1GDS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-protein signaling Rap1A regulation pathway
    		G-protein signaling Rap1A regulation pathway1.00
    		G-protein signaling_Rap1B regulation pathway0.21
    		G-protein signaling_Rap1A regulation pathway0.88
    		G-protein signaling Rap1B regulation pathway0.21
    2G-protein signaling Regulation of RAC1 activity
    		G-protein signaling Regulation of RAC1 activity1.00
    		G-protein signaling_Regulation of RAC1 activity0.88
    3G-protein signaling_RhoA regulation pathway
    		G-protein signaling_RhoA regulation pathway1.00
    		G-protein signaling RhoA regulation pathway1.00
    4G-protein signaling K-RAS regulation pathway
    		G-protein signaling K-RAS regulation pathway1.00
    		G-protein signaling_K-RAS regulation pathway0.96
    5Regulation of RAC1 activity
    		Regulation of RAC1 activity1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for RAP1GDS1
        G-protein signaling K-RAS regulation pathway
    G-protein signaling Rap1B regulation pathway
    G-protein signaling Rap1A regulation pathway
    G-protein signaling RhoA regulation pathway
    G-protein signaling Regulation of RAC1 activity


    5 GeneGo (Thomson Reuters) Pathways for RAP1GDS1
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap1B regulation pathway
    G-protein signaling K-RAS regulation pathway
    G-protein signaling RhoA regulation pathway

    1 BioSystems Pathway for RAP1GDS1 
        Regulation of RAC1 activity



    RAP1GDS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAP1GDS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for RAP1GDS1 (P523063 ENSP000003404544) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=4 STRING: ENSP00000309845
    RHOAP615863, ENSP000004001754I2D: score=4 STRING: ENSP00000400175
    MBIPQ9NS733, ENSP000003244444I2D: score=3 STRING: ENSP00000324444
    NRASP011113, ENSP000003585484I2D: score=3 STRING: ENSP00000358548
    RAP1AP628343, ENSP000003487864I2D: score=3 STRING: ENSP00000348786
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0043547positive regulation of GTPase activity NAS1549351


    RAP1GDS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAP1GDS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAP1GDS1

    1 HMDB Compound for RAP1GDS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about RAP1GDS1 / GDS1 

    Transcripts
    for RAP1GDS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAP1GDS1 gene (6 alternative transcripts): 
    NM_001100426.1  NM_001100427.1  NM_001100428.1  NM_001100429.1  NM_001100430.1  NM_021159.4  

    Unigene Cluster for RAP1GDS1:

    RAP1, GTP-GDP dissociation stimulator 1
    Hs.132858  [show with all ESTs]
    Unigene Representative Sequence: NM_001100426
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000509011 ENST00000503667 ENST00000380158 ENST00000508490 ENST00000264572
    ENST00000505378 ENST00000508213 ENST00000408927(uc003htx.4 uc003htw.4 uc003htv.4 uc003htz.4 uc003hty.4 uc003hua.4)
    ENST00000512857 ENST00000511379 ENST00000514122 ENST00000453712 ENST00000515187
    ENST00000510870 ENST00000511212 ENST00000507303 ENST00000408900 ENST00000339360


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    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate RAP1GDS1 (see all 41):
    hsa-miR-194* hsa-miR-607 hsa-miR-300 hsa-miR-29a hsa-miR-4305 hsa-miR-624* hsa-miR-449a hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmid: RAP1GDS1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF215923.1 AF237413.1 AK055032.1 AK295156.1 AK297543.1 AK311243.1 AY376900.1 BC001816.2 
    BC001851.2 BC098269.1 BC098334.1 BC099708.1 BC099845.1 BT006837.1 X63465.1 

    16 DOTS entries:

    DT.446633  DT.100810416  DT.95276807  DT.40197479  DT.410782  DT.95276804  DT.121241701  DT.104996 
    DT.100807769  DT.121241697  DT.100810407  DT.121241733  DT.95117211  DT.95276800  DT.100810414  DT.92431859 

    24/190 AceView cDNA sequences (see all 190):

    F07939 CB159040 BQ021595 BM988681 BX093701 BI765360 AA159877 AW961970 
    CR615990 AF237413 BU733880 AA846463 AI052055 BM709832 BM835384 BQ213358 
    F01921 AI084630 CB164488 AA860964 AI027149 F05663 BM828958 AA160876 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAP1GDS1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                                      -                                                                           
    SP5:                                      -                                                                           


    ECgene alternative splicing isoforms for RAP1GDS1

    Expression
    for RAP1GDS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAP1GDS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTACCTAGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RAP1GDS1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RAP1GDS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAP1GDS1

    SOURCE GeneReport for Unigene cluster: Hs.132858
        SABiosciences Custom PCR Arrays for RAP1GDS1
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    In Situ
    Assay Products:     
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    Orthologs
    for RAP1GDS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RAP1GDS1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rap1gds11 , 5 RAP1, GTP-GDP dissociation stimulator 11, 5 89.22(n)1
    95.38(a)1    		   3 (64.52 cM)5
    2298771  NM_001040690.11  NP_001035780.11 
     1389259065 
    chicken
    (Gallus gallus)    		 Aves RAP1GDS11 RAP1, GTP-GDP dissociation stimulator 1 84.38(n)
    90.59(a)    		   422701  NM_001031150.1  NP_001026321.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RAP1GDS16
    		 --
    		 93(a)
    		 1 ↔ 1
    		 GL343307.1(1207460-1285744)
    African clawed frog
    (Xenopus laevis)    		 Amphibia rap1gds1-A-prov2 RalB-binding protein 79.72(n)    AJ005870.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rap1gds11 RAP1, GTP-GDP dissociation stimulator 1 72.31(n)
    81.21(a)    		   100334870  XM_002666998.1  XP_002667044.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta vimar1 , 3 RAL interactor3
    visceral mesodermal armadillo-repeats1    		 30(a)3
    42.87(n)1
    33.59(a)1    		   356091  NM_057957.41  NP_477305.11 


    ENSEMBL Gene Tree for RAP1GDS1 (if available)
    TreeFam Gene Tree for RAP1GDS1 (if available) 

    Paralogs
    for RAP1GDS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAP1GDS1 gene

    RAP1GDS1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RAP1GDS1
    PGOHUM00000251239 PGOHUM00000251075 PGOHUM00000251095


    Genomic Variants
    for RAP1GDS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RAP1GDS1
         1 CNV: 92263
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAP1GDS1
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    Disorders / Diseases
    for RAP1GDS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAP1GDS1 for disorders           About GeneDecksing

    OMIM gene information: 179502    OMIM disorders: --

    9 diseases for RAP1GDS1:    About MalaCards
    non-small cell lung carcinoma    lymphocytic leukemia, acute t-cell    lymphocytic leukemia    acute lymphocytic leukemia
    aphasia    lung carcinoma    leukemia    carcinoma
    neuroblastoma

    Human Genome Epidemiology (HuGE) Navigator: RAP1GDS1 (1 document)

    Export disorders for RAP1GDS1 gene to outside databases

    Publications
    for RAP1GDS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAP1GDS1 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with RAP1GDS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma. (PubMed id 17951244)1, 3 Tew G.W....Williams C.L. (2008)
    2. SmgGDS displays differential binding and exchange activity towards different Ras isoforms. (PubMed id 11948427)1, 2 Vikis H.G.... Guan K.L. (2002)
    3. Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25. (PubMed id 8262526)1, 3 Riess O....Epplen J.T. (1993)
    4. Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21. (PubMed id 1549351)1, 2 Kikuchi A.... Takai Y. (1992)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Breast cancer cell migration is regulated through junc tional adhesion molecule-A-mediated activation of Rap1 GTPase. (PubMed id 21429211)1 McSherry E.A....Hopkins A.M. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for RAP1GDS1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing RAP1GDS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5910 HGNC: 9859 AceView: RAP1GDS1 Ensembl:ENSG00000138698 euGenes: HUgn5910
    ECgene: RAP1GDS1 H-InvDB: RAP1GDS1

    Other Databases showing RAP1GDS1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAP1GDS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAP1GDS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP1GDS1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RAP1GDS1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAP1GDS1 gene:
    Search GeneIP for patents involving RAP1GDS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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