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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAP1GDS1 Gene

protein-coding   GIFtS: 63
GCID: GC04P099182

RAP1, GTP-GDP Dissociation Stimulator 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAP1, GTP-GDP Dissociation Stimulator 11 2     GDS12
Exchange Factor SmgGDS2 3     SmgGDS2
SMG GDS Protein2 3     Rap1 GTPase-GDP Dissociation Stimulator 12
SMG P21 Stimulatory GDP/GTP Exchange Protein2 3     

External Ids:    HGNC: 98591   Entrez Gene: 59102   Ensembl: ENSG000001386987   OMIM: 1795025   UniProtKB: P523063   

Export aliases for RAP1GDS1 gene to outside databases

Previous GC identifers: GC04P099428 GC04P099575 GC04P099641 GC04P099539 GC04P094951


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAP1GDS1 Gene:
The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase
activity (Riess et al., 1993 (PubMed 8262526)).(supplied by OMIM, Feb 2010)

GeneCards Summary for RAP1GDS1 Gene: 
RAP1GDS1 (RAP1, GTP-GDP dissociation stimulator 1) is a protein-coding gene. Diseases associated with RAP1GDS1 include aphasia, and acute lymphocytic leukemia, and among its related super-pathways are G-protein signaling K-RAS regulation pathway and G-protein signaling Rap1A regulation pathway. GO annotations related to this gene include GTPase activator activity.

UniProtKB/Swiss-Prot: GDS1_HUMAN, P52306
Function: Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including
Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP
to each small G protein

Gene Wiki entry for RAP1GDS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAP1GDS1 gene promoter:
         Oct-B1   TBP   oct-B3   oct-B2   AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   S8   POU2F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAP1GDS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAP1GDS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP1GDS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23-q25   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q23-q25

RAP1GDS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP1GDS1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P099182:  view genomic region     (about GC identifiers)

Start:
99,182,527 bp from pter      End:
99,365,012 bp from pter
Size:
182,486 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GDS1_HUMAN, P52306 (See protein sequence)
Recommended Name: Rap1 GTPase-GDP dissociation stimulator 1  
Size: 607 amino acids; 66317 Da
Secondary accessions: E9PH06 G5E9P9 Q499L7 Q4KMV2 Q4QQI8 Q9BUW9 Q9BUX6 Q9NYM2 Q9NZA8
Alternative splicing: 6 isoforms:  P52306-1   P52306-2   P52306-3   P52306-4   P52306-5   P52306-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAP1GDS1: NX_P52306

Explore proteomics data for RAP1GDS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52306

  • RAP1GDS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAP1GDS1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001093896.1  NP_001093897.1  NP_001093898.1  NP_001093899.1  NP_001093900.1  NP_066982.3  

    ENSEMBL proteins: 
     ENSP00000425992   ENSP00000422348   ENSP00000369503   ENSP00000422426   ENSP00000264572  
     ENSP00000426096   ENSP00000386153   ENSP00000424324   ENSP00000407157   ENSP00000424250  
     ENSP00000421599   ENSP00000386223   ENSP00000340454   ENSP00000421482   ENSP00000475933  

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    Cloud-Clone Corp. Proteins for RAP1GDS1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000221vacuolar proton-transporting V-type ATPase, V1 domain ----
    GO:0005575cellular_component ND--

    RAP1GDS1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARMC: Armadillo repeat containing

    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P52306

    ProtoNet protein and cluster: P52306

    1 Blocks protein domain: IPB000225 Armadillo repeat

    UniProtKB/Swiss-Prot: GDS1_HUMAN, P52306
    Similarity: Contains 5 ARM repeats


    RAP1GDS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GDS1_HUMAN, P52306
    Function: Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including
    Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP
    to each small G protein

         Genatlas biochemistry entry for RAP1GDS1:
    guanine dinucleotide phosphate stimulating factor of Ras related Rho,Rac proteins,fused with NUP98 in T cell acute
    lymphocytic leukemia with translocation t(4;11)(q21;q25),in a chimeric protein 5' - NUP78 - RAP1GD1 - 3'

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity NAS1549351
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0046961proton-transporting ATPase activity, rotational mechanism ----
         
    RAP1GDS1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAP1GDS1:
     Actin fiber cells  Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Rap1gds1 (no phenotypes)

    RAP1GDS1 for phenotypes           About GeneDecksing

    Animal Models:
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    hsa-miR-194* hsa-miR-607 hsa-miR-300 hsa-miR-29a hsa-miR-4305 hsa-miR-624* hsa-miR-449a hsa-miR-218
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAP1GDS1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1G-protein signaling K-RAS regulation pathway
    G-protein signaling K-RAS regulation pathway0.96
    2G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap1A regulation pathway0.88
    3G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of RAC1 activity0.88
    4G-protein signaling RhoA regulation pathway
    G-protein signaling RhoA regulation pathway1.00
    5G-protein signaling Rap1B regulation pathway
    G-protein signaling Rap1B regulation pathway1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for RAP1GDS1
        G-protein signaling K-RAS regulation pathway
    G-protein signaling Rap1B regulation pathway
    G-protein signaling Rap1A regulation pathway
    G-protein signaling RhoA regulation pathway
    G-protein signaling Regulation of RAC1 activity


    5 GeneGo (Thomson Reuters) Pathways for RAP1GDS1
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap1B regulation pathway
    G-protein signaling K-RAS regulation pathway
    G-protein signaling RhoA regulation pathway

    1 BioSystems Pathway for RAP1GDS1
        Regulation of RAC1 activity



    RAP1GDS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAP1GDS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for RAP1GDS1 (P523063 ENSP000003404544) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=4 STRING: ENSP00000309845
    RHOAP615863, ENSP000004001754I2D: score=4 STRING: ENSP00000400175
    MBIPQ9NS733, ENSP000003244444I2D: score=3 STRING: ENSP00000324444
    NRASP011113, ENSP000003585484I2D: score=3 STRING: ENSP00000358548
    RAP1AP628343, ENSP000003487864I2D: score=3 STRING: ENSP00000348786
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0015991ATP hydrolysis coupled proton transport ----
    GO:0043547positive regulation of GTPase activity NAS1549351

    RAP1GDS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAP1GDS1 (GDS1)

    1 HMDB Compound for RAP1GDS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RAP1GDS1 / GDS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAP1GDS1 gene (6 alternative transcripts): 
    NM_001100426.1  NM_001100427.1  NM_001100428.1  NM_001100429.1  NM_001100430.1  NM_021159.4  

    Unigene Cluster for RAP1GDS1:

    RAP1, GTP-GDP dissociation stimulator 1
    Hs.132858  [show with all ESTs]
    Unigene Representative Sequence: NM_001100426
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000509011 ENST00000503667 ENST00000380158 ENST00000508490 ENST00000264572
    ENST00000505378 ENST00000508213 ENST00000408927(uc003htx.4 uc003htw.4 uc003htv.4 uc003htz.4 uc003hty.4 uc003hua.4)
    ENST00000512857 ENST00000511379 ENST00000514122 ENST00000453712 ENST00000515187
    ENST00000510870 ENST00000511212 ENST00000507303 ENST00000408900 ENST00000339360

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    hsa-miR-194* hsa-miR-607 hsa-miR-300 hsa-miR-29a hsa-miR-4305 hsa-miR-624* hsa-miR-449a hsa-miR-218
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    Additional mRNA sequence: 

    AF215923.1 AF237413.1 AK055032.1 AK295156.1 AK297543.1 AK311243.1 AY376900.1 BC001816.2 
    BC001851.2 BC098269.1 BC098334.1 BC099708.1 BC099845.1 BT006837.1 X63465.1 

    16 DOTS entries:

    DT.446633  DT.100810416  DT.95276807  DT.40197479  DT.410782  DT.95276804  DT.121241701  DT.104996 
    DT.100807769  DT.121241697  DT.100810407  DT.121241733  DT.95117211  DT.95276800  DT.100810414  DT.92431859 

    24/190 AceView cDNA sequences (see all 190):

    BQ772239 CB136170 AW169435 NM_021159 F03039 BG696741 AW028577 BC001851 
    CA430602 F07939 BI765360 BX093701 AI243599 BQ014546 AI361836 AI084630 
    BQ213358 AI027149 AA860964 BM835384 CR615990 AF237413 CB164488 AA846463 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAP1GDS1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                                      -                                                                           
    SP5:                                      -                                                                           


    ECgene alternative splicing isoforms for RAP1GDS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAP1GDS1 expression in normal human tissues (normalized intensities)      RAP1GDS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACCTAGAG
    RAP1GDS1 Expression
    About this image


    RAP1GDS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Medulla Oblongata
             ganglion/cranial/facial VII   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

     -- (Reproductive System)
             visceral organ/genital tubercle of male/glans of male genital tubercle   

    See RAP1GDS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAP1GDS1

    SOURCE GeneReport for Unigene cluster: Hs.132858
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAP1GDS1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap1gds11 , 5 RAP1, GTP-GDP dissociation stimulator 11, 5 89.22(n)1
    95.38(a)1
      3 (64.52 cM)5
    2298771  NM_001040690.11  NP_001035780.11 
     1389259065 
    chicken
    (Gallus gallus)
    Aves RAP1GDS11 RAP1, GTP-GDP dissociation stimulator 1 84.38(n)
    90.59(a)
      422701  NM_001031150.1  NP_001026321.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAP1GDS16
    RAP1, GTP-GDP dissociation stimulator 1
    93(a)
    1 ↔ 1
    GL343307.1(1176805-1285744)
    African clawed frog
    (Xenopus laevis)
    Amphibia rap1gds1-A-prov2 RalB-binding protein 79.72(n)    AJ005870.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rap1gds11 RAP1, GTP-GDP dissociation stimulator 1 72.31(n)
    81.21(a)
      100334870  XM_002666998.1  XP_002667044.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vimar1 , 3 RAL interactor3
    visceral mesodermal armadillo-repeats1
    30(a)3
    42.87(n)1
    33.59(a)1
      356091  NM_057957.41  NP_477305.11 


    ENSEMBL Gene Tree for RAP1GDS1 (if available)
    TreeFam Gene Tree for RAP1GDS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAP1GDS1 gene

    RAP1GDS1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RAP1GDS1
    PGOHUM00000251239 PGOHUM00000251075 PGOHUM00000251095


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3240 SNPs in RAP1GDS1 are shown (see all 3240)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs746929851,2
    C,F--99180591(+) TATTCA/GTATGT 6 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1839827191,2
    --99180606(+) GTCCTA/CACCCT 6 -- us2k10--------
    rs1886731371,2
    --99180612(+) ACCCTC/TAGTCC 6 -- us2k10--------
    rs769123941,2
    C--99180635(+) CCTGAC/TTTGGA 6 -- us2k10--------
    rs1917384551,2
    --99180637(+) TGATTA/TGGAAA 6 -- us2k10--------
    rs792695071,2
    C--99180642(+) TGGAAA/GTAGGG 6 -- us2k10--------
    rs1851580981,2
    --99180696(+) TGGTTC/TGCCCC 6 -- us2k10--------
    rs1449734781,2
    --99180697(+) GGTTCA/GCCCCT 6 -- us2k10--------
    rs789953211,2
    C,F--99180766(+) GGAGAA/GCAGCC 6 -- us2k11Minor allele frequency- G:0.07WA 118
    rs1899887561,2
    --99180802(+) ATATGC/TCAAGA 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAP1GDS1 (99182527 - 99365012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RAP1GDS1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677923CNV Deletion23128226
    nsv879653CNV Loss21882294
    nsv528127CNV Gain19592680
    nsv879652CNV Gain21882294
    nsv879651CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179502    OMIM disorders: --

    6 diseases for RAP1GDS1:    About MalaCards
    aphasia    acute lymphocytic leukemia    non-small cell lung carcinoma    neuroblastoma
    leukemia    breast cancer


    RAP1GDS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAP1GDS1
    Human Genome Epidemiology (HuGE) Navigator: RAP1GDS1 (1 document)

    Export disorders for RAP1GDS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAP1GDS1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with RAP1GDS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of biochemical traits in Korcula Island, Croatia. (PubMed id 19260141)1, 4 Zemunik T....Rudan I. (2009)
    2. SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma. (PubMed id 17951244)1, 3 Tew G.W....Williams C.L. (2008)
    3. SmgGDS displays differential binding and exchange activity towards different Ras isoforms. (PubMed id 11948427)1, 2 Vikis H.G.... Guan K.L. (2002)
    4. Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25. (PubMed id 8262526)1, 3 Riess O....Epplen J.T. (1993)
    5. Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21. (PubMed id 1549351)1, 2 Kikuchi A.... Takai Y. (1992)
    6. Statins exert the pleiotropic effects through small GT P-binding protein dissociation stimulator upregulation with a resultant Rac1 deg radation. (PubMed id 23640485)1 Tanaka S....Shimokawa H. (2013)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5910 HGNC: 9859 AceView: RAP1GDS1 Ensembl:ENSG00000138698 euGenes: HUgn5910
    ECgene: RAP1GDS1 H-InvDB: RAP1GDS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAP1GDS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP1GDS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAP1GDS1 gene:
    Search GeneIP for patents involving RAP1GDS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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