Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAP1GDS1 Gene

Aliases for RAP1GDS1 Gene

  • RAP1, GTP-GDP Dissociation Stimulator 1 2 3
  • SMG P21 Stimulatory GDP/GTP Exchange Protein 3 4
  • Exchange Factor SmgGDS 3 4
  • SMG GDS Protein 3 4
  • SmgGDS 3
  • GDS1 3

External Ids for RAP1GDS1 Gene

Previous GeneCards Identifiers for RAP1GDS1 Gene

  • GC04P099428
  • GC04P099575
  • GC04P099641
  • GC04P099539
  • GC04P099182
  • GC04P094951

Summaries for RAP1GDS1 Gene

Entrez Gene Summary for RAP1GDS1 Gene

  • The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]

GeneCards Summary for RAP1GDS1 Gene

RAP1GDS1 (RAP1, GTP-GDP Dissociation Stimulator 1) is a Protein Coding gene. Diseases associated with RAP1GDS1 include acute lymphocytic leukemia. Among its related pathways are Regulation of RAC1 activity and G-protein signaling_RhoA regulation pathway. GO annotations related to this gene include binding and proton-transporting ATPase activity, rotational mechanism.

UniProtKB/Swiss-Prot for RAP1GDS1 Gene

  • Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein

Gene Wiki entry for RAP1GDS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP1GDS1 Gene

Genomics for RAP1GDS1 Gene

Regulatory Elements for RAP1GDS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAP1GDS1 Gene

Chromosome:
4
Start:
98,261,376 bp from pter
End:
98,443,861 bp from pter
Size:
182,486 bases
Orientation:
Plus strand

Genomic View for RAP1GDS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAP1GDS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP1GDS1 Gene

Proteins for RAP1GDS1 Gene

  • Protein details for RAP1GDS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52306-GDS1_HUMAN
    Recommended name:
    Rap1 GTPase-GDP dissociation stimulator 1
    Protein Accession:
    P52306
    Secondary Accessions:
    • E9PH06
    • G5E9P9
    • Q499L7
    • Q4KMV2
    • Q4QQI8
    • Q9BUW9
    • Q9BUX6
    • Q9NYM2
    • Q9NZA8

    Protein attributes for RAP1GDS1 Gene

    Size:
    607 amino acids
    Molecular mass:
    66317 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAP1GDS1 Gene

neXtProt entry for RAP1GDS1 Gene

Proteomics data for RAP1GDS1 Gene at MOPED

Post-translational modifications for RAP1GDS1 Gene

  • Ubiquitination at Lys 77, Lys 101, Lys 421, Lys 445, and Lys 457
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RAP1GDS1 Gene

Domains & Families for RAP1GDS1 Gene

Gene Families for RAP1GDS1 Gene

Protein Domains for RAP1GDS1 Gene

Graphical View of Domain Structure for InterPro Entry

P52306

UniProtKB/Swiss-Prot:

GDS1_HUMAN :
  • Contains 5 ARM repeats.
Similarity:
  • Contains 5 ARM repeats.
genes like me logo Genes that share domains with RAP1GDS1: view

Function for RAP1GDS1 Gene

Molecular function for RAP1GDS1 Gene

GENATLAS Biochemistry:
guanine dinucleotide phosphate stimulating factor of Ras related Rho,Rac proteins,fused with NUP98 in T cell acute lymphocytic leukemia with translocation t(4;11)(q21;q25),in a chimeric protein 5 - NUP78 - RAP1GD1 - 3
UniProtKB/Swiss-Prot Function:
Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein

Gene Ontology (GO) - Molecular Function for RAP1GDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity NAS 1549351
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RAP1GDS1: view
genes like me logo Genes that share phenotypes with RAP1GDS1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAP1GDS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAP1GDS1 Gene

Localization for RAP1GDS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAP1GDS1 Gene COMPARTMENTS Subcellular localization image for RAP1GDS1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
mitochondrion 5

Gene Ontology (GO) - Cellular Components for RAP1GDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 24349085
GO:0005783 endoplasmic reticulum IDA 24349085
GO:0005829 cytosol IDA 24349085
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RAP1GDS1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RAP1GDS1 Gene

Pathways & Interactions for RAP1GDS1 Gene

genes like me logo Genes that share pathways with RAP1GDS1: view

SIGNOR curated interactions for RAP1GDS1 Gene

Activates:

Gene Ontology (GO) - Biological Process for RAP1GDS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IBA --
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IMP 24349085
GO:0043547 positive regulation of GTPase activity IBA --
GO:0051561 positive regulation of mitochondrial calcium ion concentration IMP 24349085
genes like me logo Genes that share ontologies with RAP1GDS1: view

Drugs & Compounds for RAP1GDS1 Gene

(1) Drugs for RAP1GDS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RAP1GDS1: view

Transcripts for RAP1GDS1 Gene

Unigene Clusters for RAP1GDS1 Gene

RAP1, GTP-GDP dissociation stimulator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAP1GDS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAP1GDS1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1:
SP2:
SP3:
SP4: -
SP5: -

Relevant External Links for RAP1GDS1 Gene

GeneLoc Exon Structure for
RAP1GDS1
ECgene alternative splicing isoforms for
RAP1GDS1

Expression for RAP1GDS1 Gene

mRNA expression in normal human tissues for RAP1GDS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAP1GDS1 Gene

This gene is overexpressed in Bone (12.7), Brain (7.9), and Spinal cord (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAP1GDS1 Gene



SOURCE GeneReport for Unigene cluster for RAP1GDS1 Gene Hs.132858

genes like me logo Genes that share expression patterns with RAP1GDS1: view

Protein tissue co-expression partners for RAP1GDS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAP1GDS1 Gene

Orthologs for RAP1GDS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAP1GDS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAP1GDS1 35
  • 93.84 (n)
  • 96.23 (a)
RAP1GDS1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAP1GDS1 35
  • 95.67 (n)
  • 97.69 (a)
RAP1GDS1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rap1gds1 35
  • 89.2 (n)
  • 95.37 (a)
Rap1gds1 16
Rap1gds1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAP1GDS1 35
  • 99.64 (n)
  • 99.46 (a)
RAP1GDS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rap1gds1 35
  • 89.12 (n)
  • 96.65 (a)
oppossum
(Monodelphis domestica)
Mammalia RAP1GDS1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves RAP1GDS1 35
  • 84.38 (n)
  • 90.59 (a)
RAP1GDS1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAP1GDS1 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486041 35
  • 78.27 (n)
  • 85.64 (a)
Str.784 35
African clawed frog
(Xenopus laevis)
Amphibia rap1gds1-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii rap1gds1 35
  • 72.22 (n)
  • 81.02 (a)
RAP1GDS1 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta vimar 37
  • 30 (a)
vimar 35
  • 43.1 (n)
  • 34.14 (a)
vimar 36
  • 27 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005262 35
  • 44.37 (n)
  • 35.12 (a)
Species with no ortholog for RAP1GDS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAP1GDS1 Gene

ENSEMBL:
Gene Tree for RAP1GDS1 (if available)
TreeFam:
Gene Tree for RAP1GDS1 (if available)

Paralogs for RAP1GDS1 Gene

Pseudogenes.org Pseudogenes for RAP1GDS1 Gene

genes like me logo Genes that share paralogs with RAP1GDS1: view

No data available for Paralogs for RAP1GDS1 Gene

Variants for RAP1GDS1 Gene

Sequence variations from dbSNP and Humsavar for RAP1GDS1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_049158 -
VAR_069149 -

Structural Variations from Database of Genomic Variants (DGV) for RAP1GDS1 Gene

Variant ID Type Subtype PubMed ID
nsv879651 CNV Gain 21882294
nsv879652 CNV Gain 21882294
nsv528127 CNV Gain 19592680
nsv879653 CNV Loss 21882294
esv2677923 CNV Deletion 23128226

Variation tolerance for RAP1GDS1 Gene

Residual Variation Intolerance Score: 31.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAP1GDS1 Gene

HapMap Linkage Disequilibrium report
RAP1GDS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAP1GDS1 Gene

Disorders for RAP1GDS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAP1GDS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute lymphocytic leukemia
  • acute lymphoblastic leukemia
- elite association

Relevant External Links for RAP1GDS1

Genetic Association Database (GAD)
RAP1GDS1
Human Genome Epidemiology (HuGE) Navigator
RAP1GDS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAP1GDS1
genes like me logo Genes that share disorders with RAP1GDS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAP1GDS1 Gene

Publications for RAP1GDS1 Gene

  1. SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma. (PMID: 17951244) Tew G.W. … Williams C.L. (J. Biol. Chem. 2008) 2 67
  2. The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia. (PMID: 10477737) Hussey D.J. … Dobrovic A. (Blood 1999) 23 67
  3. Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25. (PMID: 8262526) Riess O. … Epplen J.T. (Hum. Genet. 1993) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67

Products for RAP1GDS1 Gene

Sources for RAP1GDS1 Gene

Back to Top

Content