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Aliases for RAP1GAP2 Gene

Aliases for RAP1GAP2 Gene

  • RAP1 GTPase Activating Protein 2 2 3
  • GTPase-Activating Rap/Ran-GAP Domain-Like Protein 4 3 4
  • GTPase Activating Rap/RanGAP Domain-Like 4 2 3
  • GTPase Activating RANGAP Domain-Like 4 2 3
  • GARNL4 3 4
  • KIAA1039 4
  • Rap1GAP2 4
  • RAP1GA3 3
  • RAP1GA2 4

External Ids for RAP1GAP2 Gene

Previous HGNC Symbols for RAP1GAP2 Gene

  • GARNL4

Previous GeneCards Identifiers for RAP1GAP2 Gene

  • GC17P002646
  • GC17P002680

Summaries for RAP1GAP2 Gene

Entrez Gene Summary for RAP1GAP2 Gene

  • This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for RAP1GAP2 Gene

RAP1GAP2 (RAP1 GTPase Activating Protein 2) is a Protein Coding gene. Among its related pathways are Immune System and Rap1 signalling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SIPA1L2.

UniProtKB/Swiss-Prot for RAP1GAP2 Gene

  • GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP1GAP2 Gene

Genomics for RAP1GAP2 Gene

Genomic Location for RAP1GAP2 Gene

2,755,698 bp from pter
3,037,741 bp from pter
282,044 bases
Plus strand

Genomic View for RAP1GAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAP1GAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP1GAP2 Gene

No data available for Regulatory Elements for RAP1GAP2 Gene

Proteins for RAP1GAP2 Gene

  • Protein details for RAP1GAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rap1 GTPase-activating protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RTY5
    • Q684P4
    • Q6AI00
    • Q6ZVF0
    • Q9UPW2

    Protein attributes for RAP1GAP2 Gene

    730 amino acids
    Molecular mass:
    80056 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAP1GAP2 Gene


neXtProt entry for RAP1GAP2 Gene

Proteomics data for RAP1GAP2 Gene at MOPED

Post-translational modifications for RAP1GAP2 Gene

  • In vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not regulate GAP activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAP1GAP2 Gene

No data available for DME Specific Peptides for RAP1GAP2 Gene

Domains & Families for RAP1GAP2 Gene

Protein Domains for RAP1GAP2 Gene


Suggested Antigen Peptide Sequences for RAP1GAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rap-GAP domain.
  • Contains 1 Rap-GAP domain.
genes like me logo Genes that share domains with RAP1GAP2: view

No data available for Gene Families for RAP1GAP2 Gene

Function for RAP1GAP2 Gene

Molecular function for RAP1GAP2 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for RAP1GAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 24284068
genes like me logo Genes that share ontologies with RAP1GAP2: view

Phenotypes for RAP1GAP2 Gene

GenomeRNAi human phenotypes for RAP1GAP2:
genes like me logo Genes that share phenotypes with RAP1GAP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAP1GAP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAP1GAP2 Gene

Localization for RAP1GAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP1GAP2 Gene

Cytoplasm. Cytoplasm, perinuclear region.

Subcellular locations from

Jensen Localization Image for RAP1GAP2 Gene COMPARTMENTS Subcellular localization image for RAP1GAP2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for RAP1GAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IGI 24284068
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with RAP1GAP2: view

Pathways & Interactions for RAP1GAP2 Gene

SuperPathways for RAP1GAP2 Gene

genes like me logo Genes that share pathways with RAP1GAP2: view

Pathways by source for RAP1GAP2 Gene

3 Reactome pathways for RAP1GAP2 Gene

Gene Ontology (GO) - Biological Process for RAP1GAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008361 regulation of cell size IMP 24284068
GO:0010977 negative regulation of neuron projection development IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAP1GAP2: view

No data available for SIGNOR curated interactions for RAP1GAP2 Gene

Drugs & Compounds for RAP1GAP2 Gene

No Compound Related Data Available

Transcripts for RAP1GAP2 Gene

Unigene Clusters for RAP1GAP2 Gene

RAP1 GTPase activating protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAP1GAP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAP1GAP2 Gene

No ASD Table

Relevant External Links for RAP1GAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAP1GAP2 Gene

mRNA expression in normal human tissues for RAP1GAP2 Gene

Protein differential expression in normal tissues from HIPED for RAP1GAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.5) and Platelet (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAP1GAP2 Gene

SOURCE GeneReport for Unigene cluster for RAP1GAP2 Gene Hs.499659

mRNA Expression by UniProt/SwissProt for RAP1GAP2 Gene

Tissue specificity: Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas.
genes like me logo Genes that share expression patterns with RAP1GAP2: view

Protein tissue co-expression partners for RAP1GAP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAP1GAP2 Gene

Orthologs for RAP1GAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAP1GAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAP1GAP2 35
  • 91.14 (n)
  • 94.25 (a)
  • 90 (a)
(Canis familiaris)
Mammalia RAP1GAP2 35
  • 90.4 (n)
  • 94.1 (a)
  • 94 (a)
(Mus musculus)
Mammalia Rap1gap2 35
  • 89.55 (n)
  • 94.09 (a)
Rap1gap2 16
Rap1gap2 36
  • 94 (a)
(Pan troglodytes)
Mammalia RAP1GAP2 35
  • 97.95 (n)
  • 97.63 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rap1gap2 35
  • 88.24 (n)
  • 94.65 (a)
(Monodelphis domestica)
Mammalia RAP1GAP2 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia RAP1GAP2 36
  • 84 (a)
(Gallus gallus)
Aves RAP1GAP2 35
  • 81.12 (n)
  • 85.73 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia RAP1GAP2 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495015 35
  • 72.1 (n)
  • 79.07 (a)
(Danio rerio)
Actinopterygii rap1gap2b 35
  • 66.81 (n)
  • 65.15 (a)
rap1gap2a 36
  • 70 (a)
rap1gap2b 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rapgap1 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea F53A10.2 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for RAP1GAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP1GAP2 Gene

Gene Tree for RAP1GAP2 (if available)
Gene Tree for RAP1GAP2 (if available)

Paralogs for RAP1GAP2 Gene

Paralogs for RAP1GAP2 Gene

(1) SIMAP similar genes for RAP1GAP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RAP1GAP2: view

Variants for RAP1GAP2 Gene

Sequence variations from dbSNP and Humsavar for RAP1GAP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs10805 -- 3,037,426(-) AAGGG(G/T)AACAC utr-variant-3-prime
rs123059 -- 2,796,641(+) TGCAT(C/T)GGCGG intron-variant, upstream-variant-2KB
rs178557 -- 2,801,872(-) GAAAC(A/G)CAGAG intron-variant
rs178558 -- 2,801,648(+) ACATc(A/T)cacac intron-variant
rs178559 -- 2,801,387(-) agtga(G/T)tctcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAP1GAP2 Gene

Variant ID Type Subtype PubMed ID
dgv3037n71 CNV Loss 21882294
esv2660206 CNV Deletion 23128226
nsv907546 CNV Loss 21882294
dgv524e199 CNV Deletion 23128226
esv2664485 CNV Deletion 23128226
esv2425553 CNV Deletion 19546169
nsv907547 CNV Loss 21882294
nsv512470 CNV Loss 21212237
esv2659929 CNV Deletion 23128226
esv2627871 CNV Insertion 19546169
esv2677834 CNV Deletion 23128226
esv1353865 CNV Insertion 17803354
esv2674855 CNV Deletion 23128226
nsv112042 CNV Loss 16902084
esv2661610 CNV Deletion 23128226
dgv3039n71 CNV Loss 21882294
dgv439e201 CNV Deletion 23290073
esv2715508 CNV Deletion 23290073
esv2715510 CNV Deletion 23290073
esv2715511 CNV Deletion 23290073
esv2573108 CNV Deletion 19546169
esv994444 CNV Deletion 20482838
dgv440e201 CNV Deletion 23290073
esv2715513 CNV Deletion 23290073
esv29841 CNV Gain 19812545
nsv821347 CNV Deletion 20802225
esv1759238 CNV Deletion 17803354
esv1684182 CNV Deletion 17803354
esv2715515 CNV Deletion 23290073
esv2740912 CNV Deletion 23290073
dgv441e201 CNV Deletion 23290073
esv2715517 CNV Deletion 23290073
esv1118636 CNV Deletion 17803354
dgv3040n71 CNV Loss 21882294
esv2715520 CNV Deletion 23290073
esv2715521 CNV Deletion 23290073
esv2715522 CNV Deletion 23290073
nsv7288 OTHER Inversion 18451855
esv2072081 CNV Deletion 18987734
esv24712 CNV Loss 19812545
nsv821474 CNV Duplication 20802225
esv1294904 CNV Insertion 17803354
esv2715523 CNV Deletion 23290073
esv2742768 CNV Deletion 23290073
esv2715524 CNV Deletion 23290073
esv2715525 CNV Deletion 23290073

Variation tolerance for RAP1GAP2 Gene

Residual Variation Intolerance Score: 15.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.49; 91.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAP1GAP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAP1GAP2 Gene

Disorders for RAP1GAP2 Gene

Relevant External Links for RAP1GAP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RAP1GAP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAP1GAP2 Gene

Publications for RAP1GAP2 Gene

  1. Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. (PMID: 15632203) Schultess J. … Smolenski A.P. (Blood 2005) 2 67
  2. Genome-wide interaction studies reveal sex-specific asthma risk alleles. (PMID: 24824216) Myers R.A. … Nicolae D.L. (Hum. Mol. Genet. 2014) 67
  3. Slp2-a controls renal epithelial cell size through regulation of Rap-ezrin signaling independently of Rab27. (PMID: 24284068) Yasuda T. … Fukuda M. (J. Cell. Sci. 2014) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 67

Products for RAP1GAP2 Gene

Sources for RAP1GAP2 Gene

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