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RAP1GAP2 Gene

protein-coding   GIFtS: 53
GCID: GC17P002680

RAP1 GTPase Activating Protein 2

(Previous names: GTPase activating RANGAP domain-like 4, GTPase activating...)
(Previous symbol: GARNL4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAP1 GTPase Activating Protein 21 2     RAP1GA32
GARNL41 2 3     Rap1 GTPase-Activating Protein 22
GTPase Activating RANGAP Domain-Like 41 2     KIAA10393
GTPase Activating Rap/RanGAP Domain-Like 41 2     RAP1GA23
GTPase-Activating Rap/Ran-GAP Domain-Like Protein 42 3     Rap1GAP23

External Ids:    HGNC: 291761   Entrez Gene: 231082   Ensembl: ENSG000001323597   UniProtKB: Q684P53   

Export aliases for RAP1GAP2 gene to outside databases

Previous GC identifer: GC17P002646


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAP1GAP2 Gene:
This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in
platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense
granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for RAP1GAP2 Gene:
RAP1GAP2 (RAP1 GTPase activating protein 2) is a protein-coding gene. Diseases associated with RAP1GAP2 include endotheliitis, and coronary artery disease. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SIPA1.

UniProtKB/Swiss-Prot: RPGP2_HUMAN, Q684P5
Function: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the
putatively inactive GDP-bound state




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RAP1GAP2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAP1GAP2 promoter sequence
   Search Chromatin IP Primers for RAP1GAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAP1GAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

RAP1GAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP1GAP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P002680:  view genomic region     (about GC identifiers)

Start:
2,680,350 bp from pter      End:
2,941,035 bp from pter
Size:
260,686 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RPGP2_HUMAN, Q684P5 (See protein sequence)
Recommended Name: Rap1 GTPase-activating protein 2  
Size: 730 amino acids; 80056 Da
Secondary accessions: B2RTY5 Q684P4 Q6AI00 Q6ZVF0 Q9UPW2
Alternative splicing: 3 isoforms:  Q684P5-1   Q684P5-2   Q684P5-3   

Explore the universe of human proteins at neXtProt for RAP1GAP2: NX_Q684P5

Explore proteomics data for RAP1GAP2 at MOPED

Post-translational modifications: 

  • In vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not
    regulate GAP activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAP1GAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001093868.1  NP_055900.4  

    ENSEMBL proteins: 
     ENSP00000439688   ENSP00000254695   ENSP00000389824   ENSP00000444890  
    Reactome Protein details: Q684P5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000331 Rap_GAP_dom

    Graphical View of Domain Structure for InterPro Entry Q684P5

    ProtoNet protein and cluster: Q684P5

    1 Blocks protein domain: IPB000331 Rap/ran-GAP

    UniProtKB/Swiss-Prot: RPGP2_HUMAN, Q684P5
    Similarity: Contains 1 Rap-GAP domain


    RAP1GAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPGP2_HUMAN, Q684P5
    Function: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the
    putatively inactive GDP-bound state

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
         
    RAP1GAP2 for ontologies           About GeneDecksing


    Animal Models:
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    miRTarBase miRNAs that target RAP1GAP2:
    hsa-mir-652-3p (MIRT039493), hsa-mir-149-5p (MIRT045523), hsa-mir-222-3p (MIRT046810), hsa-mir-181b-5p (MIRT047265)

    Block miRNA regulation of human, mouse, rat RAP1GAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAP1GAP2 (see all 53):
    hsa-miR-323-3p hsa-miR-29a hsa-miR-650 hsa-miR-192 hsa-miR-3916 hsa-miR-3923 hsa-miR-124 hsa-miR-3908
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPGP2_HUMAN, Q684P5: Cytoplasm. Cytoplasm, perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0031965nuclear membrane IDA--
    GO:0048471perinuclear region of cytoplasm IEA--

    RAP1GAP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAP1GAP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Rap1 signalling
    Rap1 signalling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for RAP1GAP2
        Rap1 signalling



    RAP1GAP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAP1GAP2
    Interactions:

        Search GeneGlobe Interaction Network for RAP1GAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for RAP1GAP2 (Q684P53 ENSP000002546954) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    RAP1GAPENSP000003638974STRING: ENSP00000363897
    RASGRP1ENSP000003102444STRING: ENSP00000310244
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051056regulation of small GTPase mediated signal transduction IEA--

    RAP1GAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAP1GAP2 (RPGP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RAP1GAP2 gene (2 alternative transcripts): 
    NM_001100398.1  NM_015085.4  

    Unigene Cluster for RAP1GAP2:

    RAP1 GTPase activating protein 2
    Hs.499659  [show with all ESTs]
    Unigene Representative Sequence: AJ628446
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540393 ENST00000254695(uc010ckd.3) ENST00000366401(uc010cke.3)
    ENST00000574515 ENST00000575979 ENST00000571555 ENST00000574709 ENST00000542807

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    Selected qRT-PCR Assays for microRNAs that regulate RAP1GAP2 (see all 53):
    hsa-miR-323-3p hsa-miR-29a hsa-miR-650 hsa-miR-192 hsa-miR-3916 hsa-miR-3923 hsa-miR-124 hsa-miR-3908
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AJ628446.1 AJ628447.1 AK000478.1 AK127021.1 BC037493.1 BC140870.1 BC140871.1 CR627427.1 

    11 DOTS entries:

    DT.100733844  DT.305882  DT.92019563  DT.100754994  DT.91965452  DT.120957070  DT.438305  DT.97772934 
    DT.120957061  DT.120957090  DT.86840456 

    Selected AceView cDNA sequences (see all 93):

    AL534952 BU857899 BM728780 BX646705 CD653723 R27224 CR617475 BM791211 
    AJ628447 AI675965 AI669323 AL550030 AA714570 BQ233312 AI444991 CB110895 
    AW874484 BC037493 AI352338 AJ628446 BE047159 NM_015085 T06969 CB153463 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAP1GAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACGACGAC
    RAP1GAP2 Expression
    About this image


    RAP1GAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RAP1GAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAP1GAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.499659

    UniProtKB/Swiss-Prot: RPGP2_HUMAN, Q684P5
    Tissue specificity: Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form.
    Expressed in lymphocytes, heart, testis and pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RAP1GAP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap1gap21 , 5 RAP1 GTPase activating protein 21, 5 89.55(n)1
    94.09(a)1
      11 (45.76 cM)5
    3807111  NM_001015046.21  NP_001015046.11 
     743833565 
    chicken
    (Gallus gallus)
    Aves RAP1GAP21 RAP1 GTPase activating protein 2 81.12(n)
    85.73(a)
      427841  NM_001031478.2  NP_001026649.2 
    lizard
    (Anolis carolinensis)
    Reptilia RAP1GAP26
    RAP1 GTPase activating protein 2
    84(a)
    1 ↔ 1
    GL343638.1(139170-309862)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004950151 rap1 GTPase-activating protein 2-like 72.1(n)
    79.07(a)
      100495015  XM_002935298.2  XP_002935344.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rap1gap2b1 RAP1 GTPase activating protein 2b 66.81(n)
    65.15(a)
      100170821  NM_001130656.1  NP_001124128.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rapgap16
    Rapgap1
    30(a)
    1 → many
    2L(7497805-7576604)
    worm
    (Caenorhabditis elegans)
    Secernentea F53A10.26
    Protein F53A10.2, isoform c (F53A10.2) mRNA, compl...
    32(a)
    1 → many
    II(1197374-1230780) WBGene00018734


    ENSEMBL Gene Tree for RAP1GAP2 (if available)
    TreeFam Gene Tree for RAP1GAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAP1GAP2 gene
    SIPA12  SIPA1L12  SIPA1L32  RAP1GAP2  SIPA1L22  GARNL32  
    1 SIMAP similar gene for RAP1GAP2 using alignment to 1 protein entry:     RPGP2_HUMAN:
    RAP1GAP

    RAP1GAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAP1GAP2 (see all 6423)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559054451,2
    C--2596369(+) AAAAA-/A/AA  
            
    GAAAG
    2 -- int11NA 2
    rs1489127981,2
    --2611775(+) GCTCGG/TTGAAC 2 -- int10--------
    rs47903671,2
    C--2611954(+) gtggtA/Gtgatc 2 -- int14Minor allele frequency- G:0.30WA NA CSA 125
    rs98971871,2
    C,A--2611997(+) aagcgT/Attctc 2 -- int14Minor allele frequency- A:0.16WA NA EA 244
    rs1435812651,2
    --2612022(+) TATGTA/GGCTGG 2 -- int10--------
    rs1479816811,2
    C--2612216(+) TCCTTA/TTAAGA 2 -- int10--------
    rs1821988821,2
    --2612317(+) TGTTGC/TGAATA 2 -- int10--------
    rs1845637401,2
    C--2612336(+) GTGAAC/TGTAGG 2 -- int10--------
    rs47903681,2
    C--2612370(+) tttcaA/Gttctt 2 -- int18Minor allele frequency- G:0.35WA NA CSA EA 366
    rs759219771,2
    C,F--2612379(+) TTTTGA/GGTATC 2 -- int12Minor allele frequency- G:0.25WA CSA 4

    HapMap Linkage Disequilibrium report for RAP1GAP2 (2680350 - 2930350 bp, first 250kb of RAP1GAP2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RAP1GAP2 (see all 46):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715522CNV Deletion23290073
    dgv440e201CNV Deletion23290073
    esv2674855CNV Deletion23128226
    esv2742768CNV Deletion23290073
    dgv439e201CNV Deletion23290073
    esv2715513CNV Deletion23290073
    esv2740912CNV Deletion23290073
    esv2660206CNV Deletion23128226
    esv2677834CNV Deletion23128226
    esv1684182CNV Deletion17803354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for RAP1GAP2:    
    About MalaCards
    endotheliitis    coronary artery disease    tonsillitis    thyroiditis
    cerebritis    prostatitis


    RAP1GAP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAP1GAP2
    Human Genome Epidemiology (HuGE) Navigator: RAP1GAP2 (1 document)

    Export disorders for RAP1GAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAP1GAP2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with RAP1GAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. (PubMed id 15632203)1, 2, 3 Schultess J.... Smolenski A.P. (Blood 2005)
    2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    8. Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. (PubMed id 19528539)1 NeumA1ller O....Smolenski A.P. (Blood 2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets. (PubMed id 18039662)1 Hoffmeister M....Smolenski A.P. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23108 HGNC: 29176 AceView: GARNL4 Ensembl:ENSG00000132359 euGenes: HUgn23108
    ECgene: RAP1GAP2 H-InvDB: RAP1GAP2

    (According to HUGE)
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    HUGE: KIAA1039

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAP1GAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAP1GAP2 gene:
    Search GeneIP for patents involving RAP1GAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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