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Aliases for RAP1GAP2 Gene

Aliases for RAP1GAP2 Gene

  • RAP1 GTPase Activating Protein 2 2 3 5
  • GTPase-Activating Rap/Ran-GAP Domain-Like Protein 4 3 4
  • GTPase Activating Rap/RanGAP Domain-Like 4 2 3
  • GTPase Activating RANGAP Domain-Like 4 2 3
  • GARNL4 3 4
  • Rap1 GTPase-Activating Protein 2 3
  • KIAA1039 4
  • Rap1GAP2 4
  • RAP1GA3 3
  • RAP1GA2 4

External Ids for RAP1GAP2 Gene

Previous HGNC Symbols for RAP1GAP2 Gene

  • GARNL4

Previous GeneCards Identifiers for RAP1GAP2 Gene

  • GC17P002646
  • GC17P002680

Summaries for RAP1GAP2 Gene

Entrez Gene Summary for RAP1GAP2 Gene

  • This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for RAP1GAP2 Gene

RAP1GAP2 (RAP1 GTPase Activating Protein 2) is a Protein Coding gene. Among its related pathways are Rap1 signalling and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RAP1GAP.

UniProtKB/Swiss-Prot for RAP1GAP2 Gene

  • GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

Additional gene information for RAP1GAP2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP1GAP2 Gene

Genomics for RAP1GAP2 Gene

Regulatory Elements for RAP1GAP2 Gene

Enhancers for RAP1GAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H002390 1.9 FANTOM5 ENCODE dbSUPER 15 -356.7 -356687 18.6 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 ZNF585B METTL16 PRPF8 SMYD4 HNRNPA1P16 SMG6 MNT TSR1 ENSG00000263345 SGSM2 RPA1
GH17H002851 1.3 Ensembl ENCODE dbSUPER 17.8 +98.1 98069 3.7 MXI1 E2F1 HIC1 ZFHX2 ZBTB48 ZNF600 PRDM10 KLF8 ZBTB20 EZH2 RAP1GAP2 METTL16 ENSG00000261916 GC17M002857 GC17M002839
GH17H002958 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10 +204.7 204746 3 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZBTB7B GLIS2 FOS SP5 DPH1 RAP1GAP2 ENSG00000263345 OR3A2 OR1G1 LOC101927911 GC17P002937
GH17H003001 1.5 Ensembl ENCODE dbSUPER 10.2 +248.2 248151 4.3 FOXA2 SIN3A BRCA1 ZNF2 YY1 GLIS2 ATF7 RUNX3 REST ZNF610 OR1D5 OR1D2 OR1E3 OR1D3P OR3A4P SAMD11P1 EIF4A1P9 OR1E2 ENSG00000262869 RAP1GAP2
GH17H002975 1.6 Ensembl ENCODE dbSUPER 8.6 +220.0 220000 1.3 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 DEK METTL16 LOC105371492 RN7SL608P TSR1 HNRNPA1P16 RPL21P125 SMG6 ENSG00000262692 HIC1 DPH1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAP1GAP2 on UCSC Golden Path with GeneCards custom track

Promoters for RAP1GAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090272 -198 201 KLF1 KLF17 ZNF2 E2F1 ZFHX2 POLR2A ZBTB48 PATZ1 ZNF600 KLF7

Genomic Locations for RAP1GAP2 Gene

Genomic Locations for RAP1GAP2 Gene
282,044 bases
Plus strand

Genomic View for RAP1GAP2 Gene

Genes around RAP1GAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAP1GAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAP1GAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP1GAP2 Gene

Proteins for RAP1GAP2 Gene

  • Protein details for RAP1GAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rap1 GTPase-activating protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RTY5
    • Q684P4
    • Q6AI00
    • Q6ZVF0
    • Q9UPW2

    Protein attributes for RAP1GAP2 Gene

    730 amino acids
    Molecular mass:
    80056 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAP1GAP2 Gene


neXtProt entry for RAP1GAP2 Gene

Post-translational modifications for RAP1GAP2 Gene

  • In vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not regulate GAP activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAP1GAP2 Gene

Domains & Families for RAP1GAP2 Gene

Gene Families for RAP1GAP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAP1GAP2 Gene


Suggested Antigen Peptide Sequences for RAP1GAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAP1GAP2: view

No data available for UniProtKB/Swiss-Prot for RAP1GAP2 Gene

Function for RAP1GAP2 Gene

Molecular function for RAP1GAP2 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

Phenotypes From GWAS Catalog for RAP1GAP2 Gene

Gene Ontology (GO) - Molecular Function for RAP1GAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity EXP 16076873
GO:0005515 protein binding IPI 24284068
genes like me logo Genes that share ontologies with RAP1GAP2: view

Phenotypes for RAP1GAP2 Gene

MGI mutant phenotypes for RAP1GAP2:
inferred from 1 alleles
GenomeRNAi human phenotypes for RAP1GAP2:
genes like me logo Genes that share phenotypes with RAP1GAP2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAP1GAP2 Gene

Localization for RAP1GAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP1GAP2 Gene

Cytoplasm. Cytoplasm, perinuclear region.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAP1GAP2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAP1GAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IGI 24284068
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with RAP1GAP2: view

Pathways & Interactions for RAP1GAP2 Gene

genes like me logo Genes that share pathways with RAP1GAP2: view

Pathways by source for RAP1GAP2 Gene

3 Reactome pathways for RAP1GAP2 Gene

Gene Ontology (GO) - Biological Process for RAP1GAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008361 regulation of cell size IMP 24284068
GO:0010977 negative regulation of neuron projection development IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAP1GAP2: view

No data available for SIGNOR curated interactions for RAP1GAP2 Gene

Drugs & Compounds for RAP1GAP2 Gene

No Compound Related Data Available

Transcripts for RAP1GAP2 Gene

Unigene Clusters for RAP1GAP2 Gene

RAP1 GTPase activating protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAP1GAP2 Gene

No ASD Table

Relevant External Links for RAP1GAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAP1GAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAP1GAP2 Gene

Protein differential expression in normal tissues from HIPED for RAP1GAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.5) and Platelet (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAP1GAP2 Gene

Protein tissue co-expression partners for RAP1GAP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAP1GAP2 Gene:


SOURCE GeneReport for Unigene cluster for RAP1GAP2 Gene:


mRNA Expression by UniProt/SwissProt for RAP1GAP2 Gene:

Tissue specificity: Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas.

Evidence on tissue expression from TISSUES for RAP1GAP2 Gene

  • Nervous system(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with RAP1GAP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAP1GAP2 Gene

Orthologs for RAP1GAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAP1GAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAP1GAP2 33 34
  • 97.95 (n)
(Bos Taurus)
Mammalia RAP1GAP2 33 34
  • 91.14 (n)
(Canis familiaris)
Mammalia RAP1GAP2 33 34
  • 90.4 (n)
(Mus musculus)
Mammalia Rap1gap2 33 16 34
  • 89.55 (n)
(Rattus norvegicus)
Mammalia Rap1gap2 33
  • 88.24 (n)
(Monodelphis domestica)
Mammalia RAP1GAP2 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia RAP1GAP2 34
  • 84 (a)
(Gallus gallus)
Aves RAP1GAP2 33 34
  • 81.12 (n)
(Anolis carolinensis)
Reptilia RAP1GAP2 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495015 33
  • 72.1 (n)
(Danio rerio)
Actinopterygii rap1gap2a 34
  • 70 (a)
rap1gap2b 33 34
  • 66.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rapgap1 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea F53A10.2 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
Species where no ortholog for RAP1GAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP1GAP2 Gene

Gene Tree for RAP1GAP2 (if available)
Gene Tree for RAP1GAP2 (if available)

Paralogs for RAP1GAP2 Gene

Paralogs for RAP1GAP2 Gene

(1) SIMAP similar genes for RAP1GAP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RAP1GAP2: view

Variants for RAP1GAP2 Gene

Sequence variations from dbSNP and Humsavar for RAP1GAP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000004387 -- 2,875,712(+) CCTCC(A/G)TCTCG intron-variant
rs1000012902 -- 2,966,091(+) CTGAG(A/T)TGCAC intron-variant, upstream-variant-2KB
rs1000042148 -- 2,920,369(+) CAGGG(A/G)CCCCC intron-variant
rs1000046494 -- 3,023,108(+) ACAAA(A/T)CCCAT intron-variant
rs1000047982 -- 2,805,061(+) TGCAT(C/T)ACATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAP1GAP2 Gene

Variant ID Type Subtype PubMed ID
nsv821474 CNV duplication 20802225
nsv821347 CNV deletion 20802225
nsv7288 OTHER inversion 18451855
nsv574228 CNV loss 21841781
nsv574227 CNV loss 21841781
nsv574226 CNV loss 21841781
nsv512470 CNV loss 21212237
nsv478918 CNV novel sequence insertion 20440878
nsv475761 CNV novel sequence insertion 20440878
nsv472505 CNV novel sequence insertion 20440878
nsv472336 CNV novel sequence insertion 20440878
nsv1130702 CNV deletion 24896259
nsv112042 CNV deletion 16902084
nsv1071362 CNV deletion 25765185
nsv1070795 CNV deletion 25765185
nsv1065764 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv1057894 CNV gain 25217958
esv994444 CNV deletion 20482838
esv3639732 CNV loss 21293372
esv3639731 CNV loss 21293372
esv3639730 CNV loss 21293372
esv3639729 CNV loss 21293372
esv3639728 CNV loss 21293372
esv3639727 CNV loss 21293372
esv3639726 CNV loss 21293372
esv3639724 CNV loss 21293372
esv3639723 CNV loss 21293372
esv3639722 CNV loss 21293372
esv3582487 CNV loss 25503493
esv3554008 CNV deletion 23714750
esv3429880 CNV insertion 20981092
esv29841 CNV gain 19812545
esv2742768 CNV deletion 23290073
esv2740912 CNV deletion 23290073
esv2715525 CNV deletion 23290073
esv2715524 CNV deletion 23290073
esv2715523 CNV deletion 23290073
esv2715522 CNV deletion 23290073
esv2715521 CNV deletion 23290073
esv2715520 CNV deletion 23290073
esv2715517 CNV deletion 23290073
esv2715515 CNV deletion 23290073
esv2715513 CNV deletion 23290073
esv2715511 CNV deletion 23290073
esv2715510 CNV deletion 23290073
esv2715508 CNV deletion 23290073
esv2677834 CNV deletion 23128226
esv2674855 CNV deletion 23128226
esv2664485 CNV deletion 23128226
esv2661610 CNV deletion 23128226
esv2660206 CNV deletion 23128226
esv2659929 CNV deletion 23128226
esv2627871 CNV insertion 19546169
esv2573108 CNV deletion 19546169
esv24712 CNV loss 19812545
esv2425553 CNV deletion 19546169
esv2072081 CNV deletion 18987734
esv1759238 CNV deletion 17803354
esv1684182 CNV deletion 17803354
esv1353865 CNV insertion 17803354
esv1294904 CNV insertion 17803354
esv1118636 CNV deletion 17803354
dgv69n73 CNV deletion 24416366
dgv524e199 CNV deletion 23128226
dgv404e201 CNV deletion 23290073
dgv403e201 CNV deletion 23290073
dgv402e201 CNV deletion 23290073
dgv1405n106 CNV deletion 24896259

Variation tolerance for RAP1GAP2 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.49; 91.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAP1GAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAP1GAP2 Gene

Disorders for RAP1GAP2 Gene

Relevant External Links for RAP1GAP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAP1GAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAP1GAP2 Gene

Publications for RAP1GAP2 Gene

  1. Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. (PMID: 15632203) Schultess J … Smolenski AP (Blood 2005) 2 3 4 60
  2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 45 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 60
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 60

Products for RAP1GAP2 Gene

Sources for RAP1GAP2 Gene

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