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Aliases for RAP1GAP Gene

Aliases for RAP1GAP Gene

  • RAP1 GTPase Activating Protein 2 3 5
  • RAP1GAP1 3 4
  • RAP1GA1 3 4
  • RAP1, GTPase Activating Protein 1 2
  • KIAA0474 4
  • Rap1GAP 4
  • RAPGAP 3

External Ids for RAP1GAP Gene

Previous HGNC Symbols for RAP1GAP Gene

  • RAP1GA1

Previous GeneCards Identifiers for RAP1GAP Gene

  • GC01M021796
  • GC01M021922
  • GC01M020166

Summaries for RAP1GAP Gene

Entrez Gene Summary for RAP1GAP Gene

  • This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]

GeneCards Summary for RAP1GAP Gene

RAP1GAP (RAP1 GTPase Activating Protein) is a Protein Coding gene. Diseases associated with RAP1GAP include Tuberous Sclerosis and Malignant Melanoma, Somatic. Among its related pathways are Development Angiotensin activation of ERK and G-protein signaling G-Protein alpha-i signaling cascades. GO annotations related to this gene include protein homodimerization activity and GTPase activator activity. An important paralog of this gene is SIPA1L2.

UniProtKB/Swiss-Prot for RAP1GAP Gene

  • GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

Gene Wiki entry for RAP1GAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP1GAP Gene

Genomics for RAP1GAP Gene

Regulatory Elements for RAP1GAP Gene

Enhancers for RAP1GAP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAP1GAP on UCSC Golden Path with GeneCards custom track

Promoters for RAP1GAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAP1GAP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RAP1GAP gene promoter:

Genomic Location for RAP1GAP Gene

21,596,215 bp from pter
21,669,375 bp from pter
73,161 bases
Minus strand

Genomic View for RAP1GAP Gene

Genes around RAP1GAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAP1GAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAP1GAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP1GAP Gene

Proteins for RAP1GAP Gene

  • Protein details for RAP1GAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rap1 GTPase-activating protein 1
    Protein Accession:
    Secondary Accessions:
    • J3QSS6
    • O75062
    • Q5T3S9
    • Q5T3T4
    • Q7Z5S8
    • Q9UQ51

    Protein attributes for RAP1GAP Gene

    663 amino acids
    Molecular mass:
    73361 Da
    Quaternary structure:
    • Homodimer and heterodimer with RAP1B.
    • Sequence=AAH54490.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA32319.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAP1GAP Gene

    Alternative splice isoforms for RAP1GAP Gene


neXtProt entry for RAP1GAP Gene

Proteomics data for RAP1GAP Gene at MOPED

Post-translational modifications for RAP1GAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAP1GAP Gene

Domains & Families for RAP1GAP Gene

Protein Domains for RAP1GAP Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GoLoco domain.
  • Contains 1 GoLoco domain.
  • Contains 1 Rap-GAP domain.
genes like me logo Genes that share domains with RAP1GAP: view

No data available for Gene Families for RAP1GAP Gene

Function for RAP1GAP Gene

Molecular function for RAP1GAP Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
UniProtKB/Swiss-Prot Induction:
By 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells.
genes like me logo Genes that share phenotypes with RAP1GAP: view

Animal Model Products

CRISPR Products

miRNA for RAP1GAP Gene

miRTarBase miRNAs that target RAP1GAP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAP1GAP Gene

Localization for RAP1GAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP1GAP Gene

Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for RAP1GAP Gene COMPARTMENTS Subcellular localization image for RAP1GAP gene
Compartment Confidence
cytosol 5
golgi apparatus 5
endosome 2
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAP1GAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IDA 10476970
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with RAP1GAP: view

Pathways & Interactions for RAP1GAP Gene

genes like me logo Genes that share pathways with RAP1GAP: view

Pathways by source for RAP1GAP Gene

SIGNOR curated interactions for RAP1GAP Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for RAP1GAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045665 negative regulation of neuron differentiation IEA --
GO:0050790 regulation of catalytic activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction IEA --
GO:1904442 negative regulation of thyroid gland epithelial cell proliferation IEA --
GO:1990792 cellular response to glial cell derived neurotrophic factor IEA --
genes like me logo Genes that share ontologies with RAP1GAP: view

Drugs & Compounds for RAP1GAP Gene

No Compound Related Data Available

Transcripts for RAP1GAP Gene

Unigene Clusters for RAP1GAP Gene

RAP1 GTPase activating protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAP1GAP Gene

No ASD Table

Relevant External Links for RAP1GAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAP1GAP Gene

mRNA expression in normal human tissues for RAP1GAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAP1GAP Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.6), Brain - Putamen (basal ganglia) (x5.7), and Brain - Caudate (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for RAP1GAP Gene

This gene is overexpressed in Brain (15.8), Islet of Langerhans (10.7), Frontal cortex (7.8), Adrenal (6.5), Fetal Brain (6.4), and Lung (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAP1GAP Gene

SOURCE GeneReport for Unigene cluster for RAP1GAP Gene Hs.148178

mRNA Expression by UniProt/SwissProt for RAP1GAP Gene

Tissue specificity: Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues.
genes like me logo Genes that share expression patterns with RAP1GAP: view

Primer Products

No data available for Protein tissue co-expression partners for RAP1GAP Gene

Orthologs for RAP1GAP Gene

This gene was present in the common ancestor of animals.

Orthologs for RAP1GAP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAP1GAP 35
  • 92.01 (n)
  • 98.04 (a)
  • 98 (a)
(Canis familiaris)
Mammalia RAP1GAP 35
  • 92.11 (n)
  • 99.21 (a)
  • 90 (a)
(Mus musculus)
Mammalia Rap1gap 35
  • 89.23 (n)
  • 94.91 (a)
Rap1gap 16
Rap1gap 36
  • 88 (a)
(Pan troglodytes)
Mammalia RAP1GAP 35
  • 99.31 (n)
  • 99.72 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rap1gap 35
  • 89.23 (n)
  • 94.09 (a)
(Ornithorhynchus anatinus)
Mammalia RAP1GAP 36
  • 94 (a)
(Gallus gallus)
Aves RAP1GAP 36
  • 70 (a)
(Anolis carolinensis)
Reptilia RAP1GAP 36
  • 80 (a)
(Danio rerio)
Actinopterygii rap1gap 35
  • 71.44 (n)
  • 77.4 (a)
rap1gap 36
  • 74 (a)
RAP1GAP (1 of 3) 36
  • 72 (a)
RAP1GAP (3 of 3) 36
  • 88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rapgap1 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea F53A10.2 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for RAP1GAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAP1GAP Gene

Gene Tree for RAP1GAP (if available)
Gene Tree for RAP1GAP (if available)

Paralogs for RAP1GAP Gene

(2) SIMAP similar genes for RAP1GAP Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RAP1GAP: view

Variants for RAP1GAP Gene

Sequence variations from dbSNP and Humsavar for RAP1GAP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035547 A breast cancer sample
VAR_035548 A breast cancer sample
rs2275363 - 21,614,062(-) TGGAC(A/G)CTGCC nc-transcript-variant, reference, missense
rs710946 -- 21,621,358(-) ACCCC(G/T)GCAGT intron-variant
rs710947 -- 21,626,029(+) ATGAA(A/G)ATAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAP1GAP Gene

Variant ID Type Subtype PubMed ID
nsv870456 CNV Gain 21882294
esv34155 CNV Loss 18971310
dgv42e1 CNV Complex 17122850
nsv428432 CNV Gain 18775914
nsv834391 CNV Loss 17160897
nsv517096 CNV Loss 19592680
dgv189n71 CNV Loss 21882294
nsv871612 CNV Loss 21882294
nsv871706 CNV Loss 21882294
nsv508359 CNV Loss 20534489
nsv509002 CNV Insertion 20534489
dgv191n71 CNV Loss 21882294
nsv470704 CNV Gain 18288195
nsv871036 CNV Loss 21882294
dgv192n71 CNV Loss 21882294
nsv870959 CNV Loss 21882294
esv1002267 CNV Deletion 20482838
nsv871675 CNV Loss 21882294
nsv460751 CNV Loss 19166990
nsv870764 CNV Loss 21882294

Variation tolerance for RAP1GAP Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.25; 90.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAP1GAP Gene

Disorders for RAP1GAP Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAP1GAP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tuberous sclerosis
  • bourneville's disease
malignant melanoma, somatic
  • familial melanoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RAP1GAP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RAP1GAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAP1GAP Gene

Publications for RAP1GAP Gene

  1. Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. (PMID: 1904317) Rubinfeld B. … Polakis P. (Cell 1991) 2 3 4 67
  2. Loss of Rap1GAP in papillary thyroid cancer. (PMID: 19066305) Nellore A. … Brose M.S. (J. Clin. Endocrinol. Metab. 2009) 3 23
  3. Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. (PMID: 19147557) Zheng H. … Cornelius L.A. (Cancer Res. 2009) 3 23
  4. Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. (PMID: 15657046) Jordan J.D. … Iyengar R. (J. Biol. Chem. 2005) 3 23
  5. Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability. (PMID: 14660640) Tsygankova O.M. … Meinkoth J.L. (J. Biol. Chem. 2004) 3 23

Products for RAP1GAP Gene

Sources for RAP1GAP Gene