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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAP1GAP Gene

protein-coding   GIFtS: 60
GCID: GC01M021922

RAP1 GTPase Activating Protein

(Previous names: RAP1, GTPase activating protein 1)
(Previous symbol: RAP1GA1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAP1 GTPase Activating Protein1 2     RAPGAP2
RAP1GA11 2 3 5     Rap1 GTPase-Activating Protein 12
RAP1, GTPase Activating Protein 11     KIAA04743
RAP1GAP12     Rap1GAP3
RAP1GAPII2     Rap1GAP13

External Ids:    HGNC: 98581   Entrez Gene: 59092   Ensembl: ENSG000000768647   OMIM: 6002785   UniProtKB: P477363   

Export aliases for RAP1GAP gene to outside databases

Previous GC identifers: GC01M021796 GC01M020166


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAP1GAP Gene:
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related
RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active
GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to
the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by
facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such
as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1
plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis.
Alternative splicing results in multiple transcript variants encoding distinct proteins. (provided by RefSeq, Aug
2011)

GeneCards Summary for RAP1GAP Gene: 
RAP1GAP (RAP1 GTPase activating protein) is a protein-coding gene. Diseases associated with RAP1GAP include t lymphocyte deficiency, and tuberous sclerosis complex, and among its related super-pathways are Development Angiotensin activation of ERK and Immune System. GO annotations related to this gene include GTPase activator activity and protein homodimerization activity. An important paralog of this gene is SIPA1.

UniProtKB/Swiss-Prot: RPGP1_HUMAN, P47736
Function: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the
putatively inactive GDP-bound state

Gene Wiki entry for RAP1GAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAP1GAP gene promoter:
         c-Fos   AP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAP1GAP promoter sequence
   Search SABiosciences Chromatin IP Primers for RAP1GAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP1GAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1-p35   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.1-p35

RAP1GAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP1GAP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M021922:  view genomic region     (about GC identifiers)

Start:
21,922,708 bp from pter      End:
21,995,856 bp from pter
Size:
73,149 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPGP1_HUMAN, P47736 (See protein sequence)
Recommended Name: Rap1 GTPase-activating protein 1  
Size: 663 amino acids; 73361 Da
Subunit: Homodimer and heterodimer with RAP1B
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein
Sequence caution: Sequence=AAH54490.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA32319.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RAP1GAP:
1SRQ (3D)        3BRW (3D)    
Secondary accessions: J3QSS6 O75062 Q5T3S9 Q5T3T4 Q7Z5S8 Q9UQ51
Alternative splicing: 4 isoforms:  P47736-1   P47736-2   P47736-3   P47736-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAP1GAP: NX_P47736

Explore proteomics data for RAP1GAP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P47736

  • RAP1GAP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAP1GAP Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001139129.1  NP_001139130.1  NP_002876.2  

    ENSEMBL proteins: 
     ENSP00000363895   ENSP00000431364   ENSP00000363897   ENSP00000434033   ENSP00000441661  
     ENSP00000352739   ENSP00000470945   ENSP00000315420   ENSP00000392717   ENSP00000290101  
     ENSP00000363893  
    Reactome Protein details: P47736
    Human Recombinant Protein Products for RAP1GAP: 
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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005829cytosol TAS--
    GO:0016020membrane IDA10476970

    RAP1GAP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003109 GoLoco_motif
     IPR000331 Rap_GAP_dom

    Graphical View of Domain Structure for InterPro Entry P47736

    ProtoNet protein and cluster: P47736

    2 Blocks protein domains:
    IPB000331 Rap/ran-GAP
    IPB003109 G-alpha GTPase activator


    UniProtKB/Swiss-Prot: RPGP1_HUMAN, P47736
    Similarity: Contains 1 GoLoco domain
    Similarity: Contains 1 Rap-GAP domain


    RAP1GAP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPGP1_HUMAN, P47736
    Function: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the
    putatively inactive GDP-bound state
    Induction: By 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS10476970
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI18309292
    GO:0017016Ras GTPase binding IPI18309292
    GO:0030695GTPase regulator activity ----
         
    RAP1GAP for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RAP1GAP:
     Decreased POU5F1-GFP protein e  Decreased viability of wild-ty  Enable proliferation in B-Raf   Increased circadian period len 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAP1GAP 
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    SwitchGear 3'UTR luciferase reporter plasmidRAP1GAP 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAP1GAP About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Angiotensin activation of ERK
    Development ACM2 and ACM4 activation of ERK0.74
    Development G-Proteins mediated regulation MARK-ERK signaling0.66
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap1A regulation pathway0.88
    4G-protein signaling G-Protein alpha-i signaling cascades
    G-protein signaling G-Protein alpha-i signaling cascades0.55
    5TSH signaling pathway
    TSH signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for RAP1GAP
        Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling G-Protein alpha-i signaling cascades
    G-protein signaling Rap1A regulation pathway
    Development ACM2 and ACM4 activation of ERK


    4 GeneGo (Thomson Reuters) Pathways for RAP1GAP
        G-protein signaling Rap1A regulation pathway
    Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling G-Protein alpha-i signaling cascades
    Development ACM2 and ACM4 activation of ERK

    2 BioSystems Pathways for RAP1GAP
        IL-5 Signaling Pathway
    TSH signaling pathway

    3        Reactome Pathways for RAP1GAP
        Adaptive Immune System
    Immune System
    Rap1 signalling



    RAP1GAP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAP1GAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/29 Interacting proteins for RAP1GAP (P477362, 3 ENSP000003638974) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYNC1I1O145762, 3MINT-8254910 I2D: score=2 
    MAP1LC3BQ9GZQ82, 3MINT-8259715 I2D: score=2 
    MAPK6Q166592, 3MINT-8261846 I2D: score=2 
    RAP1BP612242, 3, ENSP000002505594MINT-6543650 MINT-6543614 MINT-6543629 I2D: score=3 STRING: ENSP00000250559
    CSNK1G2P783682, 3, ENSP000002556414MINT-8252923 I2D: score=2 STRING: ENSP00000255641
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS10476970
    GO:0007165signal transduction NAS10476970
    GO:0032318regulation of Ras GTPase activity IDA18309292
    GO:0043547positive regulation of GTPase activity TAS1904317
    GO:0051056regulation of small GTPase mediated signal transduction ----

    RAP1GAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAP1GAP (RPGP1)

    Search CenterWatch for drugs/clinical trials and news about RAP1GAP / RPGP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAP1GAP gene (3 alternative transcripts): 
    NM_001145657.1  NM_001145658.1  NM_002885.2  

    Unigene Cluster for RAP1GAP:

    RAP1 GTPase activating protein
    Hs.148178  [show with all ESTs]
    Unigene Representative Sequence: NM_001145657
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374763(uc001bez.1) ENST00000471600 ENST00000374765 ENST00000495204(uc001bev.3)
    ENST00000542643(uc001bey.3 uc001bex.3) ENST00000359708 ENST00000374757
    ENST00000599760 ENST00000317967 ENST00000447293 ENST00000482984 ENST00000464457
    ENST00000290101(uc001bew.3) ENST00000374761
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    Additional mRNA sequence: 

    AB003930.1 BC035030.1 BC054490.1 M64788.1 

    13 DOTS entries:

    DT.444087  DT.75103776  DT.40131644  DT.95173739  DT.95356964  DT.100770272  DT.95226098  DT.100666567 
    DT.91746729  DT.92016787  DT.95173737  DT.95173741  DT.91852883 

    24/165 AceView cDNA sequences (see all 165):

    AB007943 BG910145 BQ186077 BM666453 AI479469 AI458791 BM742308 CR612391 
    BU179603 AA358656 AI679336 AA340975 M64788 NM_002885 AW167486 AI038959 
    BM824259 BM662191 BU539538 BC054490 BI041062 BM753192 BQ897083 AI872151 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAP1GAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RAP1GAP Expression
    About this image


    See RAP1GAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAP1GAP

    SOURCE GeneReport for Unigene cluster: Hs.148178

    UniProtKB/Swiss-Prot: RPGP1_HUMAN, P47736
    Tissue specificity: Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex
    and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAP1GAP gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap1gap1 , 5 Rap1 GTPase-activating protein1, 5 89.23(n)1
    94.91(a)1
      4 (70.02 cM)5
    1103511  NM_001081155.21  NP_001074624.11 
     1376647265 
    chicken
    (Gallus gallus)
    Aves LOC7694751 rap1 GTPase-activating protein 1-like 72.78(n)
    74.59(a)
      769475  XM_001232755.2  XP_001232756.2 
    lizard
    (Anolis carolinensis)
    Reptilia RAP1GAP6
    --
    --
    78(a)
    59(a)
    1 ↔ 1
    possible ortholog
    GL343938.1(78707-94879)
    GL343381.1(99877-157598)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480396482   -- 78.46(n)    48039648 
    zebrafish
    (Danio rerio)
    Actinopterygii rap1gap1 RAP1 GTPase activating protein 72.84(n)
    79.17(a)
      100144557  NM_001123053.1  NP_001116525.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rapgap16
    CG426296
    --
    29(a)
    16(a)
    1 ↔ many
    possible ortholog
    2L(7497805-7576604)
    X(12930022-12970156)
    worm
    (Caenorhabditis elegans)
    Secernentea F53A10.26
    sipa-16
    Protein SIPA-1, isoform b
    30(a)
    15(a)
    1 ↔ many
    possible ortholog
    II(1197374-1230780)
    V(11631444-11637291)


    ENSEMBL Gene Tree for RAP1GAP (if available)
    TreeFam Gene Tree for RAP1GAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAP1GAP gene
    SIPA12  SIPA1L12  SIPA1L32  SIPA1L22  RAP1GAP22  GARNL32  
    2 SIMAP similar genes for RAP1GAP using alignment to 8 protein entries:     RPGP1_HUMAN (see all proteins):
    RAP1GAP2    SIPA1L1

    RAP1GAP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1698 SNPs in RAP1GAP are shown (see all 1698)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355484
    A breast cancer sample4--see VAR_0355482 Y C mis40--------
    VAR_0355474
    A breast cancer sample4--see VAR_0355472 C R mis40--------
    rs1487856051,2
    --20171119(+) CTGGGA/TGACAG 3 -- int10--------
    rs1424506191,2
    --20171182(+) GCTAAA/GCTATA 3 -- int10--------
    rs2013240061,2
    C--20175033(+) AAGGAA/TGNNNN 3 -- int10--------
    rs1402761651,2
    C--20189690(+) CAGAA-/AGAC  
            
    AGAGA
    3 -- int10--------
    rs717826211,2
    C--20189693(+) AAAGA-/CAGA  
            
    GAAAT
    3 -- int10--------
    rs672903661,2
    C--20190803(+) ACCTT-/GGCATG 3 -- int10--------
    rs14665181,2
    C,H--20197396(+) ttcttC/Tttttt 3 -- int1 trp30--------
    rs340689021,2
    C--20208092(+) CTATT-/AAAAAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for RAP1GAP (21922708 - 21995856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for RAP1GAP (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1002267CNV Deletion20482838
    nsv509002CNV Insertion20534489
    nsv870764CNV Loss21882294
    nsv871036CNV Loss21882294
    dgv191n71CNV Loss21882294
    nsv871612CNV Loss21882294
    nsv460751CNV Loss19166990
    nsv870959CNV Loss21882294
    nsv508359CNV Loss20534489
    nsv517096CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600278    OMIM disorders: --

    19 diseases for RAP1GAP:    About MalaCards
    t lymphocyte deficiency    tuberous sclerosis complex    bipolar i disorder    tuberous sclerosis
    thyroid cancer    myelodysplastic syndromes    renal cell carcinoma    chronic lymphocytic leukemia
    thyroiditis    pancreatic cancer    neuroblastoma    cerebritis
    squamous cell carcinoma    pancreatitis    melanoma    gastric cancer
    leukemia    endotheliitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RAP1GAP:
    Tuberous sclerosis

    RAP1GAP for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RAP1GAP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.0112 6 19147557 (2), 14660640 (1), 19066305 (1)

    Genetic Association Database (GAD): RAP1GAP
    Human Genome Epidemiology (HuGE) Navigator: RAP1GAP (1 document)

    Export disorders for RAP1GAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAP1GAP gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with RAP1GAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. (PubMed id 1904317)1, 2, 3 Rubinfeld B.... Polakis P. (1991)
    2. Human SPA-1 product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. (PubMed id 9346962)1, 2, 9 Kurachi H.... Minato N. (1997)
    3. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PubMed id 18940312)1, 4 Yuan X....Mooser V. (2008)
    4. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    5. The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. (PubMed id 18309292)1, 2 Scrima A.... Wittinghofer A. (2008)
    6. Activation of ERK/MAPK pathway by an isoform of rap1GAP associated with Gai. (PubMed id 10476970)1, 2 Mochizuki N.... Matsuda M. (1999)
    7. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
    8. Loss of Rap1GAP in papillary thyroid cancer. (PubMed id 19066305)1, 9 Nellore A....Brose M.S. (2009)
    9. Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability. (PubMed id 14660640)1, 9 Tsygankova O.M....Meinkoth J.L. (2004)
    10. Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. (PubMed id 19147557)1, 9 Zheng H....Cornelius L.A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5909 HGNC: 9858 AceView: RAP1GA1 Ensembl:ENSG00000076864 euGenes: HUgn5909
    ECgene: RAP1GAP H-InvDB: RAP1GAP

    (According to HUGE)
    About This Section
    HUGE: KIAA0474

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAP1GAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP1GAP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAP1GAP gene:
    Search GeneIP for patents involving RAP1GAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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