Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RAP1GAP Gene

protein-coding   GIFtS: 61
GCID: GC01M021922

RAP1 GTPase Activating Protein

(Previous names: RAP1, GTPase activating protein 1)
(Previous symbol: RAP1GA1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RAP1 GTPase Activating Protein1 2     RAPGAP2
RAP1GA11 2 3 5     Rap1 GTPase-Activating Protein 12
RAP1, GTPase Activating Protein 11     KIAA04743
RAP1GAP12     Rap1GAP3
RAP1GAPII2     Rap1GAP13

External Ids:    HGNC: 98581   Entrez Gene: 59092   Ensembl: ENSG000000768647   OMIM: 6002785   UniProtKB: P477363   

Export aliases for RAP1GAP gene to outside databases

Previous GC identifers: GC01M021796 GC01M020166


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RAP1GAP Gene:
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related
RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active
GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to
the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by
facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such
as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1
plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis.
Alternative splicing results in multiple transcript variants encoding distinct proteins. (provided by RefSeq, Aug
2011)

GeneCards Summary for RAP1GAP Gene:
RAP1GAP (RAP1 GTPase activating protein) is a protein-coding gene. GO annotations related to this gene include GTPase activator activity and protein homodimerization activity. An important paralog of this gene is SIPA1.

UniProtKB/Swiss-Prot: RPGP1_HUMAN, P47736
Function: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the
putatively inactive GDP-bound state

Gene Wiki entry for RAP1GAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAP1GAP gene promoter:
         c-Fos   AP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAP1GAP promoter sequence
   Search Chromatin IP Primers for RAP1GAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAP1GAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1-p35   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.1-p35

RAP1GAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP1GAP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M021922:  view genomic region     (about GC identifiers)

Start:
21,922,708 bp from pter      End:
21,995,856 bp from pter
Size:
73,149 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RPGP1_HUMAN, P47736 (See protein sequence)
Recommended Name: Rap1 GTPase-activating protein 1  
Size: 663 amino acids; 73361 Da
Subunit: Homodimer and heterodimer with RAP1B
Sequence caution: Sequence=AAH54490.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA32319.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RAP1GAP:
1SRQ (3D)        3BRW (3D)    
Secondary accessions: J3QSS6 O75062 Q5T3S9 Q5T3T4 Q7Z5S8 Q9UQ51
Alternative splicing: 4 isoforms:  P47736-1   P47736-2   P47736-3   P47736-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAP1GAP: NX_P47736

Explore proteomics data for RAP1GAP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAP1GAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001139129.1  NP_001139130.1  NP_002876.2  

    ENSEMBL proteins: 
     ENSP00000363895   ENSP00000431364   ENSP00000363897   ENSP00000434033   ENSP00000441661  
     ENSP00000352739   ENSP00000470945   ENSP00000315420   ENSP00000392717   ENSP00000290101  
     ENSP00000363893  
    Reactome Protein details: P47736

    RAP1GAP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RAP1GAP
    OriGene Protein Over-expression Lysate for RAP1GAP
    OriGene MassSpec for RAP1GAP
    OriGene Custom Protein Services for RAP1GAP
    GenScript Custom Purified and Recombinant Proteins Services for RAP1GAP
    Novus Biologicals RAP1GAP Protein
    Novus Biologicals RAP1GAP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAP1GAP

     
    Search eBioscience for Proteins for RAP1GAP 

     
    antibodies-online proteins for RAP1GAP (3 products) 

     
    antibodies-online peptides for RAP1GAP

    RAP1GAP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RAP1GAP
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RAP1GAP
    OriGene Custom Antibody Services for RAP1GAP
    Novus Biologicals RAP1GAP Antibodies
    Search for Antibodies for RAP1GAP at Abcam
    Cloud-Clone Corp. Antibodies for RAP1GAP
    ThermoFisher Antibodies for RAP1GAP
    antibodies-online antibodies for RAP1GAP (36 products) 

    RAP1GAP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAP1GAP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAP1GAP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAP1GAP
    Cloud-Clone Corp. CLIAs for RAP1GAP
    Search eBioscience for ELISAs for RAP1GAP 
    antibodies-online kits for RAP1GAP (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR003109 GoLoco_motif
     IPR000331 Rap_GAP_dom

    Graphical View of Domain Structure for InterPro Entry P47736

    ProtoNet protein and cluster: P47736

    2 Blocks protein domains:
    IPB000331 Rap/ran-GAP
    IPB003109 G-alpha GTPase activator


    UniProtKB/Swiss-Prot: RPGP1_HUMAN, P47736
    Similarity: Contains 1 GoLoco domain
    Similarity: Contains 1 Rap-GAP domain


    Find genes that share domains with RAP1GAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPGP1_HUMAN, P47736
    Function: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the
    putatively inactive GDP-bound state
    Induction: By 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS10476970
    GO:0005096GTPase activator activity TAS1904317
    GO:0005515protein binding IPI18309292
    GO:0017016Ras GTPase binding IPI18309292
    GO:0030695GTPase regulator activity ----
         
    Find genes that share ontologies with RAP1GAP           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for RAP1GAP:
     Decreased POU5F1-GFP protein e  Decreased viability of wild-ty  Enable proliferation in B-Raf   Increased circadian period len 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RAP1GAP

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAP1GAP:
    hsa-mir-215-5p (MIRT024590), hsa-mir-192-5p (MIRT026546)

    Block miRNA regulation of human, mouse, rat RAP1GAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAP1GAP (see all 23):
    hsa-miR-34b* hsa-miR-4260 hsa-miR-449a hsa-miR-764 hsa-miR-218 hsa-miR-2115 hsa-miR-320e hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidRAP1GAP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAP1GAP
    Predesigned siRNA for gene silencing in human, mouse, rat RAP1GAP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAP1GAP

    Clone
    Products:
         
    OriGene clones in human, mouse for RAP1GAP (see all 17)
    OriGene ORF clones in mouse, rat for RAP1GAP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RAP1GAP (NM_002885)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP1GAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1GAP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAP1GAP
    Browse ESI BIO Cell Lines and PureStem Progenitors for RAP1GAP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1GAP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RPGP1_HUMAN, P47736: Golgi apparatus membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    golgi apparatus5
    nucleus2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005829cytosol TAS--
    GO:0016020membrane IDA10476970

    Find genes that share ontologies with RAP1GAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RAP1GAP About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Development Angiotensin activation of ERK
    Development ACM2 and ACM4 activation of ERK0.74
    Development G Proteins mediated regulation MARK ERK signaling0.66
    2G protein signaling G Protein alpha i signaling cascades
    G protein signaling G Protein alpha i signaling cascades0.55
    3Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    4Ras signaling pathway
    Rap1 signaling pathway0.36
    5TSH signaling pathway
    TSH signaling pathway


    Find genes that share SuperPaths with RAP1GAP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAP1GAP
        Rap1 Pathway
    G-AlphaI Signaling

    4 GeneGo (Thomson Reuters) Pathways for RAP1GAP
        G-protein signaling Rap1A regulation pathway
    Development G-Proteins mediated regulation MARK-ERK signaling
    G-protein signaling G-Protein alpha-i signaling cascades
    Development ACM2 and ACM4 activation of ERK

    2 BioSystems Pathways for RAP1GAP
        IL-5 Signaling Pathway
    TSH signaling pathway

    1 Reactome Pathway for RAP1GAP
        Rap1 signalling


    1 Kegg Pathway  (Kegg details for RAP1GAP):
        Rap1 signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAP1GAP
    Interactions:

        GeneGlobe Interaction Network for RAP1GAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAP1GAP (P477361, 2, 3 ENSP000003638974) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYNC1I1O145762, 3MINT-8254910 I2D: score=2 
    MAP1LC3BQ9GZQ82, 3MINT-8259715 I2D: score=2 
    MAPK6Q166592, 3MINT-8261846 I2D: score=2 
    RAP1BP612241, 2, 3, ENSP000002505594EBI-722307,EBI-358143 MINT-6543650 MINT-6543614 MINT-6543629 I2D: score=3 STRING: ENSP00000250559
    CSNK1G2P783682, 3, ENSP000002556414MINT-8252923 I2D: score=2 STRING: ENSP00000255641
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS10476970
    GO:0007165signal transduction NAS10476970
    GO:0032318regulation of Ras GTPase activity IDA18309292
    GO:0032854positive regulation of Rap GTPase activity IDA15141215
    GO:0043547positive regulation of GTPase activity ----

    Find genes that share ontologies with RAP1GAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAP1GAP (RPGP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RAP1GAP gene (3 alternative transcripts): 
    NM_001145657.1  NM_001145658.1  NM_002885.2  

    Unigene Cluster for RAP1GAP:

    RAP1 GTPase activating protein
    Hs.148178  [show with all ESTs]
    Unigene Representative Sequence: NM_001145657
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374763(uc001bez.1) ENST00000471600 ENST00000374765 ENST00000495204(uc001bev.3)
    ENST00000542643(uc001bey.3 uc001bex.3) ENST00000359708 ENST00000374757
    ENST00000599760 ENST00000317967 ENST00000447293 ENST00000482984 ENST00000464457
    ENST00000290101(uc001bew.3) ENST00000374761
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RAP1GAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAP1GAP (see all 23):
    hsa-miR-34b* hsa-miR-4260 hsa-miR-449a hsa-miR-764 hsa-miR-218 hsa-miR-2115 hsa-miR-320e hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidRAP1GAP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RAP1GAP
    Predesigned siRNA for gene silencing in human, mouse, rat RAP1GAP
    Clone
    Products:
         
    OriGene clones in human, mouse for RAP1GAP (see all 17)
    OriGene ORF clones in mouse, rat for RAP1GAP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RAP1GAP (NM_002885)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP1GAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1GAP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RAP1GAP
    OriGene qSTAR qPCR primer pairs in human, mouse for RAP1GAP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAP1GAP
      QuantiTect SYBR Green Assays in human, mouse, rat RAP1GAP
      QuantiFast Probe-based Assays in human, mouse, rat RAP1GAP

    Additional mRNA sequence: 

    AB003930.1 BC035030.1 BC054490.1 M64788.1 

    13 DOTS entries:

    DT.444087  DT.75103776  DT.40131644  DT.95173739  DT.95356964  DT.100770272  DT.95226098  DT.100666567 
    DT.91746729  DT.92016787  DT.95173737  DT.95173741  DT.91852883 

    Selected AceView cDNA sequences (see all 165):

    AI569830 CR612391 BU179603 AI479469 AI687450 BG910145 AA340975 AI458791 
    AI872151 AI356175 AB007943 M64788 BM753192 BM662191 BC054490 BQ186077 
    AI679336 BM742308 BM824259 BI041062 BU956099 BQ897083 BM666453 AA358656 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RAP1GAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RAP1GAP Expression
    About this image


    RAP1GAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Adrenal Gland (Endocrine System)
     
     Kidney (Urinary System)
    RAP1GAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAP1GAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.148178

    UniProtKB/Swiss-Prot: RPGP1_HUMAN, P47736
    Tissue specificity: Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex
    and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues

        Custom PCR Arrays for RAP1GAP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RAP1GAP
    OriGene qSTAR qPCR primer pairs in human, mouse for RAP1GAP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAP1GAP
    QuantiTect SYBR Green Assays in human, mouse, rat RAP1GAP
    QuantiFast Probe-based Assays in human, mouse, rat RAP1GAP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1GAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RAP1GAP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap1gap1 , 5 Rap1 GTPase-activating protein1, 5 89.23(n)1
    94.91(a)1
      4 (70.02 cM)5
    1103511  NM_001081155.21  NP_001074624.11 
     1376647265 
    chicken
    (Gallus gallus)
    Aves RAP1GAP6
    RAP1 GTPase activating protein
    70(a)
    1 ↔ 1
    1(77199329-77231946)
    lizard
    (Anolis carolinensis)
    Reptilia RAP1GAP6
    RAP1 GTPase activating protein
    80(a)
    1 ↔ 1
    GL343938.1(78707-94879)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480396482   -- 78.46(n)    48039648 
    zebrafish
    (Danio rerio)
    Actinopterygii rap1gap1 RAP1 GTPase activating protein 71.44(n)
    77.4(a)
      100538309  XM_003198834.2  XP_003198882.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rapgap16
    Rapgap1
    30(a)
    1 → many
    2L(7497805-7576604)
    worm
    (Caenorhabditis elegans)
    Secernentea F53A10.26
    Protein F53A10.2, isoform c (F53A10.2) mRNA, compl...
    32(a)
    1 → many
    II(1197374-1230780) WBGene00018734


    ENSEMBL Gene Tree for RAP1GAP (if available)
    TreeFam Gene Tree for RAP1GAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RAP1GAP gene
    SIPA12  SIPA1L12  SIPA1L32  SIPA1L22  GARNL32  RAP1GAP22  
    2 SIMAP similar genes for RAP1GAP using alignment to 8 protein entries:     RPGP1_HUMAN (see all proteins):
    RAP1GAP2    SIPA1L1

    Find genes that share paralogs with RAP1GAP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RAP1GAP (see all 1698)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355484
    A breast cancer sample4--see VAR_0355482 Y C mis40--------
    VAR_0355474
    A breast cancer sample4--see VAR_0355472 C R mis40--------
    rs1487856051,2
    --20171119(+) CTGGGA/TGACAG 3 -- int10--------
    rs1424506191,2
    --20171182(+) GCTAAA/GCTATA 3 -- int10--------
    rs2013240061,2
    C--20175033(+) AAGGAA/TGNNNN 3 -- int10--------
    rs1402761651,2
    C--20189690(+) CAGAA-/AGAC  
            
    AGAGA
    3 -- int10--------
    rs717826211,2
    C--20189693(+) AAAGA-/CAGA  
            
    GAAAT
    3 -- int10--------
    rs672903661,2
    C--20190803(+) ACCTT-/GGCATG 3 -- int10--------
    rs14665181,2
    C,H--20197396(+) ttcttC/Tttttt 3 -- int1 trp30--------
    rs340689021,2
    C--20208092(+) CTATT-/AAAAAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for RAP1GAP (21922708 - 21995856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RAP1GAP (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1002267CNV Deletion20482838
    nsv509002CNV Insertion20534489
    nsv870764CNV Loss21882294
    nsv871036CNV Loss21882294
    dgv191n71CNV Loss21882294
    nsv871612CNV Loss21882294
    nsv460751CNV Loss19166990
    nsv870959CNV Loss21882294
    nsv508359CNV Loss20534489
    nsv517096CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAP1GAP
    DNA2.0 Custom Variant and Variant Library Synthesis for RAP1GAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600278    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for RAP1GAP:
    Tuberous sclerosis

    Find genes that share disorders with RAP1GAP           About GenesLikeMe

    1 Novoseek inferred disease relationship for RAP1GAP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.0112 6 19147557 (2), 14660640 (1), 19066305 (1)

    Genetic Association Database (GAD): RAP1GAP
    Human Genome Epidemiology (HuGE) Navigator: RAP1GAP (1 document)

    Export disorders for RAP1GAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RAP1GAP gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with RAP1GAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. (PubMed id 1904317)1, 2, 3 Rubinfeld B.... Polakis P. (Cell 1991)
    2. Human SPA-1 product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. (PubMed id 9346962)1, 2, 9 Kurachi H.... Minato N. (J. Biol. Chem. 1997)
    3. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PubMed id 18940312)1, 4 Yuan X....Mooser V. (Am. J. Hum. Genet. 2008)
    4. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    5. The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. (PubMed id 18309292)1, 2 Scrima A.... Wittinghofer A. (EMBO J. 2008)
    6. The GTPase-activating protein Rap1GAP uses a catalytic asparagine. (PubMed id 15141215)1, 2 Daumke O....Wittinghofer A. (Nature 2004)
    7. Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i). (PubMed id 10476970)1, 2 Mochizuki N.... Matsuda M. (Nature 1999)
    8. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (DNA Res. 1997)
    9. Loss of Rap1GAP in papillary thyroid cancer. (PubMed id 19066305)1, 9 Nellore A....Brose M.S. (J. Clin. Endocrinol. Metab. 2009)
    10. Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability. (PubMed id 14660640)1, 9 Tsygankova O.M....Meinkoth J.L. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5909 HGNC: 9858 AceView: RAP1GA1 Ensembl:ENSG00000076864 euGenes: HUgn5909
    ECgene: RAP1GAP Kegg: 5909 H-InvDB: RAP1GAP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0474

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RAP1GAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP1GAP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RAP1GAP gene:
    Search GeneIP for patents involving RAP1GAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RAP1GAP
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RAP1GAP   OriGene RNAi products in human, mouse, rat for RAP1GAP  
     OriGene qPCR primer pairs and template standards for RAP1GAP   OriGene Protein Over-expression Lysate for RAP1GAP  
     OriGene MassSpec for RAP1GAP   OriGene clones in human, mouse for RAP1GAP  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAP1GAP   OriGene Purified Protein for RAP1GAP  
     OriGene ORF clones in mouse, rat for RAP1GAP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAP1GAP   OriGene Custom Protein Services for RAP1GAP  

     
     
     Block miRNA regulation of human, mouse, rat RAP1GAP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RAP1GAP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAP1GAP Predesigned siRNA for gene silencing in human, mouse, rat RAP1GAP
     QuantiFast Probe-based Assays in human, mouse, rat RAP1GAP QuantiTect SYBR Green Assays in human, mouse, rat RAP1GAP
     Custom PCR Arrays for RAP1GAP Search Chromatin IP Primers for RAP1GAP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAP1GAP  GeneGlobe Interaction Network for RAP1GAP
     Regulatory tfbs in RAP1GAP promoter
     GenScript Custom Purified and Recombinant Proteins Services for RAP1GAP GenScript cDNA clones with any tag delivered in your preferred vector for RAP1GAP
     GenScript Custom Assay Services for RAP1GAP GenScript Custom overexpressing Cell Line Services for RAP1GAP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RAP1GAP (RPGP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RAP1GAP antibodies
     RAP1GAP proteins
     RAP1GAP lysates
     Search for Antibodies for RAP1GAP at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RAP1GAP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RAP1GAP
     Antibodies for RAP1GAP
     ELISAs for RAP1GAP
     CLIAs for RAP1GAP



     Browse ESI BIO Cell Lines and PureStem Progenitors for RAP1GAP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1GAP
     SwitchGear 3'UTR luciferase reporter plasmids for RAP1GAP
     SwitchGear Promoter luciferase reporter plasmids for RAP1GAP
     ThermoFisher Antibodies for RAP1GAP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1GAP
     Browse compounds at ApexBio
     Search Addgene for plasmids for RAP1GAP
      Search eBioscience for proteins for RAP1GAP
      Search eBioscience for elisas for RAP1GAP
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RAP1GAP
     antibodies-online antibodies for RAP1GAP (36 products)
     antibodies-online kits for RAP1GAP (2 products)
     antibodies-online peptides for RAP1GAP
     antibodies-online proteins for RAP1GAP (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAP1GAP gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4