Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAP1B Gene

Aliases for RAP1B Gene

  • RAP1B, Member Of RAS Oncogene Family 2 3
  • GTP-Binding Protein Smg P21B 3 4
  • Ras Family Small GTP Binding Protein RAP1B 3
  • Ras-Related Protein Rap-1b 3
  • RAS-Related Protein RAP1B 3
  • Small GTP Binding Protein 3
  • K-Rev 3
  • RAL1B 3

External Ids for RAP1B Gene

Previous GeneCards Identifiers for RAP1B Gene

  • GC12P068809
  • GC12P068721
  • GC12P067290
  • GC12P069005
  • GC12P066093

Summaries for RAP1B Gene

Entrez Gene Summary for RAP1B Gene

  • This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]

GeneCards Summary for RAP1B Gene

RAP1B (RAP1B, Member Of RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for RAP1B Gene

  • GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.

Gene Wiki entry for RAP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP1B Gene

Genomics for RAP1B Gene

Regulatory Elements for RAP1B Gene

Genomic Location for RAP1B Gene

Start:
68,610,839 bp from pter
End:
68,671,901 bp from pter
Size:
61,063 bases
Orientation:
Plus strand

Genomic View for RAP1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP1B Gene

Proteins for RAP1B Gene

  • Protein details for RAP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61224-RAP1B_HUMAN
    Recommended name:
    Ras-related protein Rap-1b
    Protein Accession:
    P61224
    Secondary Accessions:
    • B2R5Z2
    • B4DQI8
    • B4DW74
    • B4DW94
    • P09526
    • Q502X3
    • Q5TZR4
    • Q6DCA1
    • Q6LES0

    Protein attributes for RAP1B Gene

    Size:
    184 amino acids
    Molecular mass:
    20825 Da
    Quaternary structure:
    • Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Interacts with KRIT1.

    Three dimensional structures from OCA and Proteopedia for RAP1B Gene

    Alternative splice isoforms for RAP1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAP1B Gene

Proteomics data for RAP1B Gene at MOPED

Post-translational modifications for RAP1B Gene

  • Ubiquitination at Lys5, Lys31, and Lys128
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAP1B Gene

Domains for RAP1B Gene

Graphical View of Domain Structure for InterPro Entry

P61224

UniProtKB/Swiss-Prot:

RAP1B_HUMAN :
  • P61224
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RAP1B: view

No data available for Gene Families for RAP1B Gene

Function for RAP1B Gene

Molecular function for RAP1B Gene

GENATLAS Biochemistry: RAP1B,Ras oncogene superfamily member
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by binding to the GTPase-activating protein RAP1GAP. Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.
UniProtKB/Swiss-Prot Function: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.

Gene Ontology (GO) - Molecular Function for RAP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 18309292
GO:0005515 protein binding IPI --
GO:0005525 GTP binding IDA 18309292
GO:0019003 GDP binding IDA 18309292
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with RAP1B: view
genes like me logo Genes that share phenotypes with RAP1B: view

Animal Models for RAP1B Gene

MGI Knock Outs for RAP1B:

miRNA for RAP1B Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RAP1B Gene

Localization for RAP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP1B Gene

Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAP1B Gene COMPARTMENTS Subcellular localization image for RAP1B gene
Compartment Confidence
cytosol 5
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005811 lipid particle IDA 14741744
GO:0005829 cytosol IDA 18582561
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IDA 20332120
genes like me logo Genes that share ontologies with RAP1B: view

Pathways for RAP1B Gene

genes like me logo Genes that share pathways with RAP1B: view

Gene Ontology (GO) - Biological Process for RAP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process --
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAP1B: view

Compounds for RAP1B Gene

(1) HMDB Compounds for RAP1B Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(8) Novoseek inferred chemical compound relationships for RAP1B Gene

Compound -log(P) Hits PubMed IDs
thromboxane a2 54.9 3
adp 52.6 20
gtp 49.9 3
ly294002 45.5 1
wortmannin 42.4 2
genes like me logo Genes that share compounds with RAP1B: view

Transcripts for RAP1B Gene

Unigene Clusters for RAP1B Gene

RAP1B, member of RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAP1B Gene

No ASD Table

Relevant External Links for RAP1B Gene

GeneLoc Exon Structure for
RAP1B
ECgene alternative splicing isoforms for
RAP1B

Expression for RAP1B Gene

mRNA expression in normal human tissues for RAP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAP1B Gene

SOURCE GeneReport for Unigene cluster for RAP1B Gene Hs.369920

genes like me logo Genes that share expressions with RAP1B: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAP1B Gene

Orthologs for RAP1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAP1B 35
  • 99.82 (n)
  • 100 (a)
RAP1B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAP1B 35
  • 95.83 (n)
  • 100 (a)
RAP1B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAP1B 35
  • 96.92 (n)
  • 99.46 (a)
RAP1B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rap1b 35
  • 91.67 (n)
  • 100 (a)
Rap1b 16
Rap1b 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAP1B 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAP1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rap1b 35
  • 90.04 (n)
  • 99.46 (a)
chicken
(Gallus gallus)
Aves RAP1B 35
  • 90.94 (n)
  • 100 (a)
RAP1B 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAP1B 36
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rap1b-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rap1b 35
  • 85.14 (n)
  • 98.37 (a)
Str.6536 35
zebrafish
(Danio rerio)
Actinopterygii rap1b 35
  • 78.99 (n)
  • 96.74 (a)
rap1b 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta R 36
  • 86 (a)
OneToMany
Rap2l 37
  • 60 (a)
R 37
  • 90 (a)
worm
(Caenorhabditis elegans)
Secernentea rap-1 35
  • 72.56 (n)
  • 86.19 (a)
rap-1 36
  • 84 (a)
OneToMany
C08F8.7 37
  • 49 (a)
rrp-1 37
  • 85 (a)
C25D7.7 37
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 35
  • 60.68 (n)
  • 60.48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12001g 35
  • 62.28 (n)
  • 61.08 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8438 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8837 36
  • 83 (a)
OneToMany
Species with no ortholog for RAP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP1B Gene

ENSEMBL:
Gene Tree for RAP1B (if available)
TreeFam:
Gene Tree for RAP1B (if available)

Paralogs for RAP1B Gene

Pseudogenes.org Pseudogenes for RAP1B Gene

genes like me logo Genes that share paralogs with RAP1B: view

Variants for RAP1B Gene

Sequence variations from dbSNP and Humsavar for RAP1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs734661 -- 68,644,979(+) caggc(A/G)tgagc intron-variant
rs2277392 -- 68,611,188(-) GCGCG(C/T)CGAGG intron-variant
rs2431657 -- 68,653,495(-) TATCT(A/G)CCAAG intron-variant
rs2439744 -- 68,638,818(+) ACCAA(A/G)CCCGA intron-variant
rs2439756 -- 68,609,522(+) gagcc(A/G)agatc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAP1B Gene

Variant ID Type Subtype PubMed ID
nsv522941 CNV Gain 19592680
esv2669961 CNV Deletion 23128226

Relevant External Links for RAP1B Gene

HapMap Linkage Disequilibrium report
RAP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAP1B Gene

Disorders for RAP1B Gene

(1) Novoseek inferred disease relationships for RAP1B Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for RAP1B

Genetic Association Database (GAD)
RAP1B
Human Genome Epidemiology (HuGE) Navigator
RAP1B
genes like me logo Genes that share disorders with RAP1B: view

No data available for UniProtKB/Swiss-Prot for RAP1B Gene

Publications for RAP1B Gene

  1. cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. (PMID: 12089143) Lou L. … Altschuler D.L. (J. Biol. Chem. 2002) 2 3 23
  2. Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. (PMID: 18660803) Rehmann H. … Bos J.L. (Nature 2008) 3 4 23
  3. Mutation analysis of RAP1 gene in papillary thyroid carcinomas. (PMID: 18948674) Matsuse M. … Yamashita S. (Endocr. J. 2009) 3 23 48
  4. Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B). (PMID: 3137530) Pizon V. … Tavitian A. (Nucleic Acids Res. 1988) 2 3 4
  5. Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K. (PMID: 3141412) Bokoch G.M. … Mumby S.M. (J. Biol. Chem. 1988) 3 4

Products for RAP1B Gene

Sources for RAP1B Gene

Back to Top

Content