Aliases for RAP1B Gene
External Ids for RAP1B Gene
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]
GeneCards Summary for RAP1B Gene
RAP1B (RAP1B, Member Of RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAP2B.
UniProtKB/Swiss-Prot for RAP1B Gene
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.