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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RAP1B Gene

protein-coding GIFtS: 65
GCID: GC12P069005

RAP1B, member of RAS oncogene family

Explore 15 diseases affiliated with
RAP1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAP1B, Member Of RAS Oncogene Family¹ ²		Ras Family Small GTP Binding Protein RAP1B²
K-REV¹ ²		Ras-Related Protein Rap-1b²
RAL1B¹ ²		RAS-Related Protein RAP1B²
GTP-Binding Protein Smg P21B² ³		Small GTP Binding Protein²
DKFZp586H0723¹

External Ids:	HGNC: 9857¹	Entrez Gene: 5908²	Ensembl: ENSG00000127314⁷	OMIM: 179530⁵	UniProtKB: P61224³

Export aliases for RAP1B gene to outside databases

Previous GC identifers: GC12P068520 GC12P068809 GC12P068721 GC12P067290 GC12P066093

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAP1B:

This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate

multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular

membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in

regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes

of this gene are found on chromosomes 3, 5, 6 and 9. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: RAP1B_HUMAN, P61224

Function: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1

and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for

the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction

Gene Wiki entry for RAP1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RAP1B gene promoter:
E2F-4 E2F-3a STAT1 E2F-5 E2F-2 Tal-1beta E47 E2F-1 E2F GATA-6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAP1B promoter sequence

Search SABiosciences Chromatin IP Primers for RAP1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q14

RAP1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP1B gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P069005: view genomic region (about GC identifiers)

Start:	69,004,619 bp from pter	End:	69,054,374 bp from pter
Size:	49,756 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAP1B_HUMAN, P61224 (See protein sequence)

Recommended Name: Ras-related protein Rap-1b precursor

Size: 184 amino acids; 20825 Da

Subunit: Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Interacts with KRIT1

Subcellular location: Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and

cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction

3 PDB 3D structures from and Proteopedia for RAP1B:

3BRW (3D)

3CF6 (3D)

4DXA (3D)

Secondary accessions: B2R5Z2 B4DQI8 B4DW74 B4DW94 P09526 Q502X3 Q5TZR4 Q6DCA1 Q6LES0

Alternative splicing: 4 isoforms: P61224-1 P61224-2 P61224-3 P61224-4

Explore the universe of human proteins at neXtProt for RAP1B: NX_P61224

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61224

RAP1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001010942.1 NP_001238846.1 NP_001238847.1 NP_001238850.1 NP_001238851.1 NP_056461.1

ENSEMBL proteins:

ENSP00000250559 ENSP00000377085 ENSP00000401095 ENSP00000446027 ENSP00000390972

ENSP00000445138 ENSP00000444786 ENSP00000441275 ENSP00000439966 ENSP00000399986

ENSP00000437415 ENSP00000444467 ENSP00000438088 ENSP00000445090 ENSP00000441952

ENSP00000444060 ENSP00000368270 ENSP00000446318 ENSP00000440466 ENSP00000443775

ENSP00000444830 ENSP00000440014 ENSP00000444924 ENSP00000445977 ENSP00000440635

ENSP00000440708 ENSP00000438311 ENSP00000443851

Reactome Protein details: P61224
Human Recombinant Protein Products:

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	Uscn Proteins for RAP1B

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	--
GO:0005811	lipid particle	IDA	14741744
GO:0005829	cytosol	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005911	cell-cell junction	IDA	--

RAP1B for ontologies About GeneDecksing

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Assay Products for RAP1B:

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	Uscn ELISAs and CLIAs for RAP1B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RAP1B for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry P61224

ProtoNet protein and cluster: P61224

3 Blocks protein families:

IPB002041 GTP-binding nuclear protein Ran

IPB003577 Ras small GTPase

IPB003578 Ras small GTPase

UniProtKB/Swiss-Prot: RAP1B_HUMAN, P61224

Similarity: Belongs to the small GTPase superfamily. Ras family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RAP1B_HUMAN, P61224

Function: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1

and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for

the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction

Enzyme regulation: Activated by binding to the GTPase-activating protein RAP1GAP. Activated by guanine

nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner

Genatlas biochemistry entry for RAP1B:

RAP1B,Ras oncogene superfamily member

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RAP1B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAP1B
		8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate RAP1B (see all 117):
		hsa-miR-411* hsa-miR-140-5p hsa-miR-631 hsa-miR-128 hsa-miR-485-3p hsa-miR-578 hsa-miR-30d hsa-miR-4275

		SwitchGear 3'UTR luciferase reporter plasmid: RAP1B 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1B

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IDA	18309292
GO:0005515	protein binding	IPI	18660803
GO:0005525	GTP binding	IDA	18309292
GO:0017016	Ras GTPase binding	--	--
GO:0019003	GDP binding	IDA	18309292

RAP1B for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RAP1B:

Decreased Tat-dependent transc

Decreased p24 protein expressi

Animal Models:
Mouse knock-out Rap1b^tm1Cw for RAP1B
8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rap1b):

behavior/neurological	cardiovascular system	growth/size	hematopoietic system	homeostasis/metabolism
mortality/aging	nervous system	reproductive system

RAP1B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/32 super-pathways (see all 32) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Focal Adhesion

	Focal Adhesion	1.00			Integrin-mediated cell adhesion	0.38
	Focal adhesion	0.66			HGF Pathway	0.24

GRB2:SOS provides linkage to MAPK signaling for Intergrins

	GRB2:SOS provides linkage to MAPK signaling for Intergrins	1.00			SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow	0.41
	p130Cas linkage to MAPK signaling for integrins	0.76			SHC1 dissociates from integrin alphaIIb beta3	0.41

Regulation of Insulin Secretion

	Regulation of Insulin Secretion	1.00			Regulation of Insulin Secretion by Glucagon-like Peptide-1	0.55
	Integration of energy metabolism	0.74

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	Activation of PKA through GPCR	0.71

Rho Family GTPases

	ERK Signaling	0.61			MAPK Signaling	0.51
	Molecular Mechanisms of Cancer	0.51

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RAP1B

G-protein signaling Rap1B regulation pathway

5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAP1B (see all 17)

	MAPK Signaling
	PKA Signaling
	Molecular Mechanisms of Cancer
	Relaxin Pathway
	TRKA Signaling

2 Cell Signaling Technology (CST) Pathways for RAP1B

	Cytoskeletal Signaling
	Adhesion

1 GeneGo (Thomson Reuters) Pathway for RAP1B

G-protein signaling Rap1B regulation pathway

5/6 BioSystems Pathways for RAP1B (see all 6)

	Integrin-mediated cell adhesion
	MAPK signaling pathway
	Focal Adhesion
	TSH signaling pathway
	CXCR4-mediated signaling events

5/17 Reactome Pathways for RAP1B (see all 17)

	Metabolism
	Regulation of Insulin Secretion
	GRB2:SOS provides linkage to MAPK signaling for Intergrins
	Signal Transduction
	SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow

5/8 Kegg Pathways (Kegg details for RAP1B) (see all 8):

	MAPK signaling pathway
	Chemokine signaling pathway
	Focal adhesion
	Leukocyte transendothelial migration
	Long-term potentiation

RAP1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RAP1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/84 Interacting proteins for RAP1B (P61224^{2, 3} ENSP00000250559⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 84)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RAP1GAP	P47736²^,³, ENSP00000363897⁴	MINT-6543650 MINT-6543614 MINT-6543629 I2D: score=3 STRING: ENSP00000363897
A2M	P01023²^,³	MINT-8267995 I2D: score=2
ALAS1	P13196²^,³	MINT-8268006 I2D: score=2
APLP1	P51693²^,³	MINT-8268017 I2D: score=2
CCT7	Q99832²^,³	MINT-8268039 I2D: score=2

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006184	GTP catabolic process	--	--
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0008283	cell proliferation	IEA	--

RAP1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RAP1B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RAP1B

1 HMDB Compound for RAP1B About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

8 Novoseek chemical compound relationships for RAP1B gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thromboxane a2	54.9	3	18755689 (1), 11815620 (1), 19023091 (1)
adp	52.6	22	11815620 (7), 15078882 (7), 12407113 (3), 15863506 (2) (see all 5)
gtp	49.9	4	19651783 (1), 11815620 (1), 7737967 (1)
ly294002	45.5	1	12407113 (1)
wortmannin	42.4	2	12407113 (2)
phosphatidylinositol	41.1	1	12407113 (1)
epinephrine	20.7	4	12407113 (2), 11815620 (2)
tyrosine	8.85	7	10224142 (3), 19422462 (2), 7537700 (1)

Search CenterWatch for drugs/clinical trials and news about RAP1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RAP1B gene (6 alternative transcripts):

NM_001010942.2 NM_001251917.1 NM_001251918.1 NM_001251921.1 NM_001251922.1 NM_015646.5

Unigene Cluster for RAP1B:

RAP1B, member of RAS oncogene family

Hs.369920 [show with all ESTs]

Unigene Representative Sequence: NM_015646

18/33 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):

ENST00000250559(uc001sub.3 uc001suc.3 uc010stf.2 uc010stg.2 uc010sth.2 uc010sti.2)

ENST00000460800 ENST00000393436 ENST00000501412 ENST00000425247 ENST00000489473

ENST00000422358 ENST00000541167 ENST00000538283 ENST00000341355 ENST00000537460

ENST00000463493 ENST00000450214 ENST00000545270 ENST00000538980 ENST00000542018

ENST00000543393 ENST00000534899

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		8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate RAP1B (see all 117):
		hsa-miR-411* hsa-miR-140-5p hsa-miR-631 hsa-miR-128 hsa-miR-485-3p hsa-miR-578 hsa-miR-30d hsa-miR-4275

		SwitchGear 3'UTR luciferase reporter plasmid: RAP1B 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP1B

Additional cDNA sequence:

AB062128.1 AF279894.1 AF493913.1 AJ420497.1 AK298818.1 AK301401.1 AK301428.1 AK312371.1

AK316447.1 AK316543.1 AL080212.1 BC000176.3 BC078173.1 BC095467.1 BT020093.1 CR407689.1

X08004.1

24/47 DOTS entries (see all 47):

DT.218906 DT.91895703 DT.100639368 DT.100683942 DT.91713428 DT.102838153 DT.100683939 DT.100683941

DT.100700728 DT.121177932 DT.92457896 DT.75196106 DT.121177996 DT.100683937 DT.121177928 DT.121177942

DT.92457900 DT.95267395 DT.95267414 DT.121177956 DT.100683936 DT.121177915 DT.121177927 DT.92457907

24/504 AceView cDNA sequences (see all 504):

CB122052 BQ432330 AA809981 BU507429 BQ010320 AJ420497 AU125710 AI571273

BQ573935 BQ049354 AW502215 NM_015646 BG413482 CD515914 AA486091 AV654836

BP335529 BM968141 AW673984 AV714099 AW103494 AL080212 Z39061 BX443188

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAP1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGGGCTTG

About this image

RAP1B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RAP1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAP1B

SOURCE GeneReport for Unigene cluster: Hs.369920

SABiosciences Expression via Pathway-Focused PCR Array including RAP1B:

Focal Adhesions in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAP1B gene from 7/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RAP1B¹	RAP1B, member of RAS oncogene family	90.94(n) 100(a)		417840 NM_001007852.1 NP_001007853.1
lizard (Anolis carolinensis)	Reptilia	RAP1B⁶	--	100(a)	1 ↔ 1	GL343256.1(1362380-1372603)
African clawed frog (Xenopus laevis)	Amphibia	rap1b-prov²	RAS related protein 1b	83.94(n)		BC044988.1
zebrafish (Danio rerio)	Actinopterygii	rap1b²	RAS related protein 1b	78.96(n)		321107 AY423018.1
fruit fly (Drosophila melanogaster)	Insecta	R³	photoreceptor commitment (sensu Drosophila) GTP more	90(a) (best of 2)		3 62B7 --
worm (Caenorhabditis elegans)	Secernentea	rrp-1³	ras protein	85(a) (best of 3)		IV(8916911-8918914) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RSR1¹	Rsr1p	60.68(n) 60.48(a)		853056 NP_011668.3

ENSEMBL Gene Tree for RAP1B (if available)
TreeFam Gene Tree for RAP1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RAP1B gene

RAP2C² RASL10B² DIRAS1² RASD2² RAP2A² RAP1A² RAP2B² RASD1²

DIRAS2² RASL10A² DIRAS3²

18/111 SIMAP similar genes for RAP1B using alignment to 19 protein entries: RAP1B_HUMAN (see all proteins) (see all similar genes):

RAP1A KRAS H-RAS K-RAS RAP2A DKFZp547A0616

c-bas/has RAP2C RAP2B HRAS NRAS N-ras

RIT2 RALA MRAS RALB DIRAS2 DIRAS1

RAP1B for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for RAP1B
PGOHUM00000250296 PGOHUM00000243752 PGOHUM00000260453

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186237016^1,2		--	69002657(+)	`TACAGA/TAATTC`	6	--	us2k¹		0	--	--	--	--
rs116306859^1,2		--	69002711(+)	`AAGGTG/TTTCTA`	6	--	us2k¹		0	--	--	--	--
rs12821757^1,2	C	--	69002756(+)	`CTAACG/TCAAGG`	6	--	us2k¹		0	--	--	--	--
rs191366399^1,2		--	69002802(+)	`TTCGGA/GAGGCC`	6	--	us2k¹		0	--	--	--	--
rs111357253^1,2	C,	--	69002859(+)	`CAACAC/TGGAGA`	6	--	us2k¹		1		WA	2
rs182820100^1,2		--	69003066(+)	`AAAAAA/GAAAAT`	6	--	us2k¹		0	--	--	--	--
rs145360851^1,2		--	69003223(+)	`TGGCAC/TGCGCC`	6	--	us2k¹		0	--	--	--	--
rs149183269^1,2		--	69003260(+)	`AGACAA/GGAGAA`	6	--	us2k¹		0	--	--	--	--
rs2468424^1,2	C,F,A,	--	69003282(-)	`TCTGCT/CTCTCA`	6	--	us2k¹		7		NA WA CSA EA	366
rs143079367^1,2		--	69003292(+)	`AAATTA/CCAGTG`	6	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RAP1B (69004619 - 69054374 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAP1B: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RAP1B for disorders           About GeneDecksing

OMIM gene information: 179530    OMIM disorders: --

15 diseases for RAP1B:    About MalaCards

non-small cell lung carcinoma papillary thyroid carcinoma megakaryoblastic leukemia follicular adenoma

renal cell carcinoma squamous cell carcinoma thyroid carcinoma myelodysplastic syndrome

lung carcinoma carcinoma thyroiditis adenoma

leukemia pancreatitis neuronitis

1 Novoseek disease relationship for RAP1B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	12089143 (1)

Human Genome Epidemiology (HuGE) Navigator: RAP1B (2 documents)

Export disorders for RAP1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RAP1B gene, integrated from 9 sources (see all 89):
(articles sorted by number of sources associating them with RAP1B)

Utopia: connect your pdf to the dynamic
world of online information

Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B). (PubMed id 3137530)^{1, 2, 3} Pizon V.... Tavitian A. (1988)
cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. (PubMed id 12089143)^{1, 3, 9} Lou L....Altschuler D.L. (2002)
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. (PubMed id 18660803)^{1, 2, 9} Rehmann H....Bos J.L. (2008)
Structural basis for small G protein effector interact ion of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1). (PubMed id 22577140)^{1, 2} Li X....Boggon T.J. (2012)
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. (PubMed id 18309292)^{1, 2} Scrima A.... Wittinghofer A. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Rap1-B is phosphorylated by protein kinase A in intact human platelets. (PubMed id 1696481)^{1, 2} Siess W.... Lapetina E.G. (1990)
Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. (PubMed id 2123345)^{1, 2} Kawata M....Takai Y. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5908	HGNC: 9857	AceView: RAP1B	Ensembl:ENSG00000127314	euGenes: HUgn5908
ECgene: RAP1B	Kegg: 5908	H-InvDB: RAP1B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RAP1B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RAP1B	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/rap1b/

Intellectual Property for RAP1B gene
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Patent Information for RAP1B gene:
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GeneCards and IP:
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RAP1B, member of RAS oncogene family

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RAP1B, member of RAS oncogene family

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