Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAP1B Gene

protein-coding   GIFtS: 68
GCID: GC12P069005

RAP1B, Member Of RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAP1B, Member Of RAS Oncogene Family1 2     Ras Family Small GTP Binding Protein RAP1B2
GTP-Binding Protein Smg P21B2 3     Ras-Related Protein Rap-1b2
K-REV2     RAS-Related Protein RAP1B2
RAL1B2     Small GTP Binding Protein2

External Ids:    HGNC: 98571   Entrez Gene: 59082   Ensembl: ENSG000001273147   OMIM: 1795305   UniProtKB: P612243   

Export aliases for RAP1B gene to outside databases

Previous GC identifers: GC12P068520 GC12P068809 GC12P068721 GC12P067290 GC12P066093


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAP1B Gene:
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate
multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to
cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a
role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants.
Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. (provided by RefSeq, Oct 2011)

GeneCards Summary for RAP1B Gene: 
RAP1B (RAP1B, member of RAS oncogene family) is a protein-coding gene. Diseases associated with RAP1B include follicular adenoma, and papillary thyroid carcinoma, and among its related super-pathways are Integrin-mediated cell adhesion and Development HGF signaling pathway. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RAP1B_HUMAN, P61224
Function: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of
KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen.
Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction

Gene Wiki entry for RAP1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAP1B gene promoter:
         E2F-4   E2F-3a   STAT1   E2F-5   E2F-2   Tal-1beta   E47   E2F-1   E2F   GATA-6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAP1B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAP1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q14

RAP1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P069005:  view genomic region     (about GC identifiers)

Start:
69,004,619 bp from pter      End:
69,054,374 bp from pter
Size:
49,756 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAP1B_HUMAN, P61224 (See protein sequence)
Recommended Name: Ras-related protein Rap-1b precursor  
Size: 184 amino acids; 20825 Da
Subunit: Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Interacts with KRIT1
Subcellular location: Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane
and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction
3 PDB 3D structures from and Proteopedia for RAP1B:
3BRW (3D)        3CF6 (3D)        4DXA (3D)    
Secondary accessions: B2R5Z2 B4DQI8 B4DW74 B4DW94 P09526 Q502X3 Q5TZR4 Q6DCA1 Q6LES0
Alternative splicing: 4 isoforms:  P61224-1   P61224-2   P61224-3   P61224-4   

Explore the universe of human proteins at neXtProt for RAP1B: NX_P61224

Explore proteomics data for RAP1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61224

  • RAP1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAP1B Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001010942.1  NP_001238846.1  NP_001238847.1  NP_001238850.1  NP_001238851.1  NP_056461.1  

    ENSEMBL proteins: 
     ENSP00000250559   ENSP00000377085   ENSP00000401095   ENSP00000446027   ENSP00000390972  
     ENSP00000445138   ENSP00000444786   ENSP00000441275   ENSP00000439966   ENSP00000399986  
     ENSP00000437415   ENSP00000444467   ENSP00000438088   ENSP00000445090   ENSP00000441952  
     ENSP00000444060   ENSP00000368270   ENSP00000446318   ENSP00000440466   ENSP00000443775  
     ENSP00000444830   ENSP00000440014   ENSP00000444924   ENSP00000445977   ENSP00000440635  
     ENSP00000440708   ENSP00000438311   ENSP00000443851  
    Reactome Protein details: P61224
    Human Recombinant Protein Products for RAP1B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RAP1B
    OriGene Protein Over-expression Lysate for RAP1B
    OriGene MassSpec for RAP1B 
    OriGene Custom Protein Services for RAP1B
    GenScript Custom Purified and Recombinant Proteins Services for RAP1B
    Novus Biologicals RAP1B Proteins
    Novus Biologicals RAP1B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RAP1B
    Cloud-Clone Corp. Proteins for RAP1B 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005811lipid particle IDA14741744
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction IDA--

    RAP1B for ontologies           About GeneDecksing



    RAP1B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for RAP1B
    Cell Signaling Technology (CST) Antibodies for RAP1B 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RAP1B
    GenScript Superior Antibodies for RAP1B
    Novus Biologicals RAP1B Antibodies
    Abcam antibodies for RAP1B
    Cloud-Clone Corp. Antibodies for RAP1B 
    ThermoFisher Antibodies for RAP1B
    LSBio Antibodies in human, mouse, rat for RAP1B 

    Assay Products for RAP1B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAP1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAP1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAP1B 
    Cloud-Clone Corp. CLIAs for RAP1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P61224

    ProtoNet protein and cluster: P61224

    3 Blocks protein domains:
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAP1B_HUMAN, P61224
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RAP1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAP1B_HUMAN, P61224
    Function: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of
    KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen.
    Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction
    Enzyme regulation: Activated by binding to the GTPase-activating protein RAP1GAP. Activated by guanine
    nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner

         Genatlas biochemistry entry for RAP1B:
    RAP1B,Ras oncogene superfamily member

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA18309292
    GO:0005515protein binding IPI17318188
    GO:0005525GTP binding IDA18309292
    GO:0017016Ras GTPase binding ----
    GO:0019003GDP binding IDA18309292
         
    RAP1B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RAP1B:
     Decreased Tat-dependent transc  Decreased p24 protein expressi 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rap1b):
     behavior/neurological  cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism 
     mortality/aging  nervous system  reproductive system 

    RAP1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rap1btm1Cw for RAP1B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAP1B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAP1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAP1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAP1B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAP1B
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate RAP1B (see all 117):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-631 hsa-miR-128 hsa-miR-485-3p hsa-miR-578 hsa-miR-30d hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidRAP1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAP1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAP1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAP1B
    Sirion Biotech Customized adenovirus for overexpression of RAP1B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RAP1B (see all 13)
    OriGene ORF clones in mouse, rat for RAP1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RAP1B (NM_015646)
    Sino Biological Human cDNA Clone for RAP1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1B
    Sirion Biotech Customized lentivirus for stable overexpression of RAP1B 
                         Customized lentivirus expression plasmids for stable overexpression of RAP1B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAP1B
    Search LifeMap BioReagents cell lines for RAP1B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAP1B About   (see all 32)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    2Development HGF signaling pathway
    Neurotrophin signaling pathway0.36
    Renal cell carcinoma0.30
    Signaling of Hepatocyte Growth Factor Receptor0.35
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4Regulation of Insulin Secretion
    Regulation of Insulin Secretion0.74
    Regulation of Insulin Secretion by Glucagon-like Peptide-10.55
    Integration of energy metabolism0.74
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RAP1B
        G-protein signaling Rap1B regulation pathway

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAP1B (see all 17)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for RAP1B
        Cytoskeletal Signaling
    Adhesion

    1 GeneGo (Thomson Reuters) Pathway for RAP1B
        G-protein signaling Rap1B regulation pathway

    5/7 BioSystems Pathways for RAP1B (see all 7)
        MAPK signaling pathway
    Focal Adhesion
    Integrin-mediated cell adhesion
    TSH signaling pathway
    Prostate Cancer


    5/15        Reactome Pathways for RAP1B (see all 15)
        Hemostasis
    Integrin cell surface interactions
    Metabolism
    Regulation of Insulin Secretion
    Adaptive Immune System


    5/8         Kegg Pathways  (Kegg details for RAP1B) (see all 8):
        MAPK signaling pathway
    Chemokine signaling pathway
    Focal adhesion
    Leukocyte transendothelial migration
    Long-term potentiation


    RAP1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAP1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/92 Interacting proteins for RAP1B (P612242, 3 ENSP000002505594) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDAH2O958652, 3MINT-8268080 I2D: score=2 
    ENSG00000206395O958652, 3MINT-8268080 I2D: score=2 
    ENSG00000225635O958652, 3MINT-8268080 I2D: score=2 
    ENSG00000226634O958652, 3MINT-8268080 I2D: score=2 
    ENSG00000227317O958652, 3MINT-8268080 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----

    RAP1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAP1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAP1B

    1 HMDB Compound for RAP1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    8 Novoseek inferred chemical compound relationships for RAP1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thromboxane a2 54.9 3 18755689 (1), 11815620 (1), 19023091 (1)
    adp 52.6 22 11815620 (7), 15078882 (7), 12407113 (3), 15863506 (2) (see all 5)
    gtp 49.9 4 19651783 (1), 11815620 (1), 7737967 (1)
    ly294002 45.5 1 12407113 (1)
    wortmannin 42.4 2 12407113 (2)
    phosphatidylinositol 41.1 1 12407113 (1)
    epinephrine 20.7 4 12407113 (2), 11815620 (2)
    tyrosine 8.85 7 10224142 (3), 19422462 (2), 7537700 (1)

    Search CenterWatch for drugs/clinical trials and news about RAP1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAP1B gene (6 alternative transcripts): 
    NM_001010942.2  NM_001251917.1  NM_001251918.1  NM_001251921.1  NM_001251922.1  NM_015646.5  

    Unigene Cluster for RAP1B:

    RAP1B, member of RAS oncogene family
    Hs.369920  [show with all ESTs]
    Unigene Representative Sequence: NM_015646
    18/33 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000250559(uc001sub.3 uc001suc.3 uc010stf.2 uc010stg.2 uc010sth.2 uc010sti.2)
    ENST00000460800 ENST00000393436 ENST00000501412 ENST00000425247 ENST00000489473
    ENST00000422358 ENST00000541167 ENST00000538283 ENST00000341355 ENST00000537460
    ENST00000463493 ENST00000450214 ENST00000545270 ENST00000538980 ENST00000542018
    ENST00000543393 ENST00000534899
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAP1B
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate RAP1B (see all 117):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-631 hsa-miR-128 hsa-miR-485-3p hsa-miR-578 hsa-miR-30d hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidRAP1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAP1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAP1B
    Clone
    Products:
         
    OriGene clones in human, mouse for RAP1B (see all 13)
    OriGene ORF clones in mouse, rat for RAP1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RAP1B (NM_015646)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1B
    Sirion Biotech Customized lentivirus for stable overexpression of RAP1B 
                         Customized lentivirus expression plasmids for stable overexpression of RAP1B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RAP1B
    OriGene qSTAR qPCR primer pairs in human, mouse for RAP1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAP1B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAP1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP1B

    Additional mRNA sequence: 

    AB062128.1 AF279894.1 AF493913.1 AJ420497.1 AK298818.1 AK301401.1 AK301428.1 AK312371.1 
    AK316447.1 AK316543.1 AL080212.1 BC000176.3 BC078173.1 BC095467.1 BT020093.1 CR407689.1 
    X08004.1 

    24/47 DOTS entries (see all 47):

    DT.218906  DT.91895703  DT.100639368  DT.100683942  DT.91713428  DT.102838153  DT.100683939  DT.100683941 
    DT.100700728  DT.121177932  DT.92457896  DT.75196106  DT.121177996  DT.100683937  DT.121177928  DT.121177942 
    DT.92457900  DT.95267395  DT.95267414  DT.121177956  DT.100683936  DT.121177915  DT.121177927  DT.92457907 

    24/504 AceView cDNA sequences (see all 504):

    AF493913 BP337566 T29787 AA150731 BE049498 BE049375 AA809981 BU737778 
    BU902856 AU142899 AW502215 BM968141 BP374343 AV714099 BM974901 BE855738 
    BG388299 AA486091 AW305299 BX443188 AI581740 BQ269809 AI751635 BQ878766 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAP1B expression in normal human tissues (normalized intensities)      RAP1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGGGCTTG
    RAP1B Expression
    About this image


    RAP1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer

    See RAP1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAP1B

    SOURCE GeneReport for Unigene cluster: Hs.369920
        SABiosciences Expression via Pathway-Focused PCR Array including RAP1B: 
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RAP1B
    OriGene qSTAR qPCR primer pairs in human, mouse for RAP1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAP1B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAP1B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAP1B gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap1b1 , 5 RAS related protein 1b1, 5 91.67(n)1
    100(a)1
      10 (66.32 cM)5
    2154491  NM_024457.21  NP_077777.11 
     1178145975 
    chicken
    (Gallus gallus)
    Aves RAP1B1 RAP1B, member of RAS oncogene family 90.94(n)
    100(a)
      417840  NM_001007852.1  NP_001007853.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAP1B6
    Uncharacterized protein
    100(a)
    1 ↔ 1
    GL343256.1(1334057-1377030)
    African clawed frog
    (Xenopus laevis)
    Amphibia rap1b-prov2 RAS related protein 1b 83.94(n)    BC044988.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rap1b2 RAS related protein 1b 78.96(n)   321107  AY423018.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta R3 photoreceptor commitment (sensu
    Drosophila) GTP more
    90(a)
    (best of 2)
      3 62B7   --
    worm
    (Caenorhabditis elegans)
    Secernentea rrp-13 ras protein 85(a)
    (best of 3)
      IV(8916911-8918914)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSR11 Rsr1p 60.68(n)
    60.48(a)
      853056   NP_011668.3 


    ENSEMBL Gene Tree for RAP1B (if available)
    TreeFam Gene Tree for RAP1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAP1B gene
    RAP2C2  DIRAS12  RALA2  RIT22  RAP2A2  RIT12  RALB2  RAP1A2  
    RAP2B2  NRAS2  DIRAS22  KRAS2  HRAS2  DIRAS32  
    18/110 SIMAP similar genes for RAP1B using alignment to 19 protein entries:     RAP1B_HUMAN (see all proteins) (see all similar genes):
    RAP1A    H-RAS    K-RAS    KRAS    RAP2A    DKFZp547A0616
    c-bas/has    RAP2C    RAP2B    HRAS    NRAS    N-ras
    RIT2    RALA    MRAS    RALB    DIRAS2    DIRAS1

    RAP1B for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RAP1B
    PGOHUM00000250296 PGOHUM00000243752 PGOHUM00000260453


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/903 SNPs in RAP1B are shown (see all 903)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862370161,2
    --69002657(+) TACAGA/TAATTC 6 -- us2k10--------
    rs1163068591,2
    --69002711(+) AAGGTG/TTTCTA 6 -- us2k10--------
    rs128217571,2
    C--69002756(+) CTAACG/TCAAgg 6 -- us2k10--------
    rs1913663991,2
    --69002802(+) TTCGGA/GAGGCC 6 -- us2k10--------
    rs1113572531,2
    C,F--69002859(+) CAACAC/TGGAGA 6 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1828201001,2
    --69003066(+) AAAAAA/GAAAAT 6 -- us2k10--------
    rs1453608511,2
    --69003223(+) TGGCAC/TGCGCC 6 -- us2k10--------
    rs1491832691,2
    --69003260(+) AGACAA/GGAGAA 6 -- us2k10--------
    rs24684241,2
    C,F,A--69003282(-) tctgcT/Ctctca 6 -- us2k17Minor allele frequency- C:0.49NA WA CSA EA 366
    rs1430793671,2
    C--69003292(+) AAATTA/CCAGTG 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAP1B (69004619 - 69054374 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RAP1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669961CNV Deletion23128226
    nsv522941CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RAP1B
    DNA2.0 Custom Variant and Variant Library Synthesis for RAP1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179530    OMIM disorders: --

    14 diseases for RAP1B:    About MalaCards
    follicular adenoma    papillary thyroid carcinoma    non-small cell lung carcinoma    myelodysplastic syndromes
    thyroiditis    adenoma    esophageal squamous cell carcinoma    renal cell carcinoma
    endotheliitis    squamous cell carcinoma    esophagitis    pancreatitis
    leukemia    neuronitis


    RAP1B for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RAP1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12089143 (1)

    Genetic Association Database (GAD): RAP1B
    Human Genome Epidemiology (HuGE) Navigator: RAP1B (2 documents)

    Export disorders for RAP1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAP1B gene, integrated from 9 sources (see all 94):
    (articles sorted by number of sources associating them with RAP1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B). (PubMed id 3137530)1, 2, 3 Pizon V.... Tavitian A. (1988)
    2. cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. (PubMed id 12089143)1, 3, 9 Lou L....Altschuler D.L. (2002)
    3. Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. (PubMed id 18660803)1, 2, 9 Rehmann H....Bos J.L. (2008)
    4. Mutation Analysis of RAP1 Gene in Papillary Thyroid Carcinomas. (PubMed id 18948674)1, 4, 9 Matsuse M....Yamashita S. (2008)
    5. Structural basis for small G protein effector interact ion of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1). (PubMed id 22577140)1, 2 Li X....Boggon T.J. (2012)
    6. The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. (PubMed id 18309292)1, 2 Scrima A.... Wittinghofer A. (2008)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    10. Rap1-B is phosphorylated by protein kinase A in intact human platelets. (PubMed id 1696481)1, 2 Siess W.... Lapetina E.G. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5908 HGNC: 9857 AceView: RAP1B Ensembl:ENSG00000127314 euGenes: HUgn5908
    ECgene: RAP1B Kegg: 5908 H-InvDB: RAP1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAP1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP1B Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/rap1b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAP1B gene:
    Search GeneIP for patents involving RAP1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for RAP1B (Rap1B)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RAP1B  
     OriGene qPCR primer pairs and template standards for RAP1B   OriGene Protein Over-expression Lysate for RAP1B  
     OriGene MassSpec something-or-other for RAP1B   OriGene clones in human, mouse for RAP1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAP1B   OriGene Purified Protein for RAP1B  
     OriGene ORF clones in mouse, rat for RAP1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAP1B   OriGene Custom Protein Services for RAP1B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAP1B
     QIAGEN SeqTarget long-range PCR primers for resequencing RAP1B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP1B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAP1B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP1B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAP1B
     GenScript Custom Purified and Recombinant Proteins Services for RAP1B GenScript cDNA clones with any tag delivered in your preferred vector for RAP1B
     GenScript Custom Assay Services for RAP1B GenScript Superior Antibodies for RAP1B
     GenScript Custom overexpressing Cell Line Services for RAP1B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for RAP1B 

     Regulatory tfbs in RAP1B promoter
     Search Chromatin IP Primers for RAP1B
     RT2 qPCR Primer Assay in human, mouse, rat RAP1B
     GNC Network for RAP1B
     SABiosciences PCR Arrays including human, mouse, rat RAP1B
     Search Tocris compounds for RAP1B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for RAP1B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RAP1B antibodies
     RAP1B proteins
     RAP1B lysates
     Antibodies for RAP1B
     See all of Abcam's Antibodies, Kits and Proteins for RAP1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RAP1B




     Proteins for RAP1B
     Antibodies for RAP1B
     ELISAs for RAP1B
     CLIAs for RAP1B
     Search LifeMap BioReagents cell lines for RAP1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1B
     SwitchGear 3'UTR luciferase reporter plasmids for RAP1B
     SwitchGear Promoter luciferase reporter plasmids for RAP1B
     ThermoFisher Antibodies for RAP1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RAP1B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAP1B
    Customized:
     lentivirus for stable overexpression of RAP1B
     lentivirus expression plasmids for stable overexpression of RAP1B
     adenovirus for overexpression of RAP1B
     LSBio Antibodies in human, mouse, rat for RAP1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAP1B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4