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RAP1A Gene

protein-coding   GIFtS: 70
GCID: GC01P112084

RAP1A, Member Of RAS Oncogene Family

  See RAP1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAP1A, Member Of RAS Oncogene Family1 2     KREV-12
KREV12 3 5     RAP12
C21KG2 3     SMGP212
G-22K2 3     Ras-Related Protein Rap-1A2
GTP-Binding Protein Smg P21A2 3     RAS-Related Protein RAP1A2
Ras-Related Protein Krev-12 3     

External Ids:    HGNC: 98551   Entrez Gene: 59062   Ensembl: ENSG000001164737   OMIM: 1795205   UniProtKB: P628343   

Export aliases for RAP1A gene to outside databases

Previous GC identifers: GC01P112501 GC01P110956 GC01P111186 GC01P111383 GC01P111796 GC01P111886 GC01P111963 GC01P110105


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAP1A Gene:
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50%
amino acid identity with the classical RAS proteins and have numerous structural features in common. The most
striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is
replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because
it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein
have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAP1A Gene:
RAP1A (RAP1A, member of RAS oncogene family) is a protein-coding gene. Diseases associated with RAP1A include leukocyte adhesion deficiency, type iii, and lung adenoma. GO annotations related to this gene include protein complex binding and GTP binding. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834
Function: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic
function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together
with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor
(NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in
the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular
endothelial growth factor receptor KDR expression at endothelial cell-cell junctions

Gene Wiki entry for RAP1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAP1A gene promoter:
         HSF1short   HSF1 (long)   FOXD3   Evi-1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAP1A promoter sequence
   Search Chromatin IP Primers for RAP1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAP1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.3

RAP1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P112084:  view genomic region     (about GC identifiers)

Start:
112,084,840 bp from pter      End:
112,259,313 bp from pter
Size:
174,474 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834 (See protein sequence)
Recommended Name: Ras-related protein Rap-1A precursor  
Size: 184 amino acids; 20987 Da
Subunit: Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form
preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation
of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts
(via GTP-bound active form) with RAPGEF2 (via Ras-associating domain)
Sequence caution: Sequence=CAB55685.2; Type=Erroneous gene model prediction;
3 PDB 3D structures from and Proteopedia for RAP1A:
1C1Y (3D)        1GUA (3D)        3KUC (3D)    
Secondary accessions: P10113

Explore the universe of human proteins at neXtProt for RAP1A: NX_P62834

Explore proteomics data for RAP1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys5, Lys31, Lys128
  • Modification sites at PhosphoSitePlus

  • See RAP1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001010935.1  NP_002875.1  

    ENSEMBL proteins: 
     ENSP00000348786   ENSP00000396741   ENSP00000358723   ENSP00000394318   ENSP00000443009  
    Reactome Protein details: P62834

    RAP1A Human Recombinant Protein Products:

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    Novus Biologicals RAP1A Proteins
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    ProSpec Recombinant Protein for RAP1A
    Cloud-Clone Corp. Proteins for RAP1A

     
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    Abcam antibodies for RAP1A (P61224, P62834)
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    LSBio Antibodies in human, mouse, rat for RAP1A

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    Enzo Life Sciences assays for RAP1A
    Cloud-Clone Corp. ELISAs for RAP1A
    Cloud-Clone Corp. CLIAs for RAP1A
    Search eBioscience for ELISAs for RAP1A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P62834

    ProtoNet protein and cluster: P62834

    1 Blocks protein domain: IPB003577 Ras small GTPase

    UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834
    Similarity: Belongs to the small GTPase superfamily. Ras family


    Find genes that share domains with RAP1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAP1A_HUMAN, P62834
    Function: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic
    function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together
    with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor
    (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in
    the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular
    endothelial growth factor receptor KDR expression at endothelial cell-cell junctions
    Enzyme regulation: Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent
    manner, and GFR

         Genatlas biochemistry entry for RAP1A:
    RAP1A,Ras oncogene superfamily member (Krev1),morphologic reversion of ras-transformed cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI10608844
    GO:0005525GTP binding IEA--
    GO:0008565protein transporter activity IDA17916086
    GO:0017016Ras GTPase binding IEA--
         
    Find genes that share ontologies with RAP1A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RAP1A:
     Synthetic lethal with c-Myc af  Synthetic lethal with imatinib 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rap1a):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  immune system 
     mortality/aging  nervous system 

    Find genes that share phenotypes with RAP1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rap1atm1Laaq for RAP1A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAP1A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAP1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAP1A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAP1A

    miRNA
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    miRTarBase miRNAs that target RAP1A:
    hsa-mir-337-3p (MIRT006958), hsa-let-7e-5p (MIRT051421)

    Block miRNA regulation of human, mouse, rat RAP1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAP1A (see all 71):
    hsa-miR-520f hsa-miR-502-3p hsa-miR-877* hsa-miR-149 hsa-miR-3613-3p hsa-miR-92b hsa-miR-1298 hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidRAP1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAP1A
    Predesigned siRNA for gene silencing in human, mouse, rat RAP1A

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for RAP1A

    Clone
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    OriGene clones in human, mouse for RAP1A (see all 12)
    OriGene ORF clones in mouse, rat for RAP1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RAP1A (NM_002884)
    Sino Biological Human cDNA Clone for RAP1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1A
    Addgene plasmids for RAP1A 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAP1A_HUMAN, P62834: Cell membrane; Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction (By
    similarity). Early endosome (By similarity). Note=Recruited from early endosome to late endosome compartment
    after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity).
    Colocalized with RAPGEF2 in the perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus2
    cytoskeleton1
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11359771
    GO:0005769early endosome ISS--
    GO:0005770late endosome ISS--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with RAP1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAP1A About   (see all 60)  
    See pathways by source

    SuperPathContained pathways About
    1Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Neurotrophin signaling pathway0.36
    Development Neurotrophin family signaling0.45
    Signaling of Hepatocyte Growth Factor Receptor0.35
    2Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    HGF Pathway0.34
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4Signalling to ERKs
    Signalling to ERKs0.73
    Prolonged ERK activation events0.00
    Frs2-mediated activation0.00
    ARMS-mediated activation0.00
    5Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    GRB2-SOS provides linkage to MAPK signaling for Intergrins0.00
    Platelet Aggregation (Plug Formation)0.73
    p130Cas linkage to MAPK signaling for integrins0.00


    Find genes that share SuperPaths with RAP1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAP1A (see all 20)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for RAP1A
        Cytoskeletal Signaling
    Adhesion

    Selected GeneGo (Thomson Reuters) Pathways for RAP1A (see all 24)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    G-protein signaling G-Protein alpha-i signaling cascades
    G-protein signaling TC21 regulation pathway
    Development Beta-adrenergic receptors regulation of ERK

    Selected BioSystems Pathways for RAP1A (see all 18)
        MAPK signaling pathway
    Focal Adhesion
    Integrin-mediated cell adhesion
    Serotonin Receptor 4/6/7 and NR3C Signaling
    Integrated Breast Cancer Pathway


    Selected Reactome Pathways for RAP1A (see all 7)
        Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
    Frs2-mediated activation
    Integrin alphaIIb beta3 signaling
    ARMS-mediated activation
    p130Cas linkage to MAPK signaling for integrins

    1 PharmGKB Pathway for RAP1A
        Bisphosphonate Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for RAP1A) (see all 10):
        MAPK signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway
    Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAP1A: 
              Telomeres & Telomerase in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAP1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAP1A (P628341, 2, 3 ENSP000003487864) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity TAS--
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----

    Find genes that share ontologies with RAP1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAP1A

    2 HMDB Compounds for RAP1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Selected Novoseek inferred chemical compound relationships for RAP1A gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 71.2 55 12473665 (4), 2160589 (3), 10608844 (2), 1939245 (2) (see all 32)
    gdp 66.9 18 10608844 (2), 2110451 (2), 11292831 (1), 20170508 (1) (see all 13)
    guanosine 59.2 7 15613546 (1), 17954608 (1), 18362184 (1), 16043520 (1) (see all 6)
    forskolin 56.6 18 10908723 (4), 15345481 (1), 15601837 (1), 12464615 (1) (see all 12)
    cyclic amp 53.7 45 16507992 (6), 15546918 (3), 15591041 (3), 14985123 (3) (see all 16)
    geranylgeranyl pyrophosphate 53.2 2 12427032 (1), 17640631 (1)
    tyrosine 52.9 33 16170364 (2), 18789886 (2), 15982636 (2), 16182283 (2) (see all 22)
    mevalonate 46.3 3 12427032 (2), 11788600 (1), 17640631 (1)
    perillyl alcohol 44.2 1 9296357 (1)
    guanine 35.4 5 17383543 (1), 16681758 (1), 17993260 (1), 18039662 (1) (see all 5)



    Find genes that share compounds with RAP1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAP1A gene (2 alternative transcripts): 
    NM_001010935.1  NM_002884.2  

    Unigene Cluster for RAP1A:

    RAP1A, member of RAS oncogene family
    Hs.190334  [show with all ESTs]
    Unigene Representative Sequence: NM_001010935
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356415 ENST00000433097 ENST00000369709(uc001ebl.3) ENST00000494982
    ENST00000436150(uc001ebi.3 uc001ebk.3) ENST00000545460
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RAP1A (see all 71):
    hsa-miR-520f hsa-miR-502-3p hsa-miR-877* hsa-miR-149 hsa-miR-3613-3p hsa-miR-92b hsa-miR-1298 hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidRAP1A 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): RAP1A (NM_002884)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1A
    Addgene plasmids for RAP1A 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RAP1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAP1A
      QuantiTect SYBR Green Assays in human, mouse, rat RAP1A
      QuantiFast Probe-based Assays in human, mouse, rat RAP1A

    Additional mRNA sequence: 

    AB451235.1 AB451360.1 AF493912.1 AK293044.1 BC014086.2 BT019666.1 M22995.1 X12533.1 

    13 DOTS entries:

    DT.70101779  DT.100800672  DT.451930  DT.100800671  DT.121382734  DT.100800680  DT.95243672  DT.100028709 
    DT.99996642  DT.100800674  DT.100800676  DT.120749171  DT.75108365 

    Selected AceView cDNA sequences (see all 389):

    T53553 AF493912 BG612316 BQ269560 BQ007820 BF476324 CA414041 BX111098 
    R37585 CA421524 BE464445 AA021545 AA383199 BU167449 CD365553 CR597469 
    BG743233 BG620014 BC014086 BQ694744 BF447109 BU677958 BM759422 BQ009973 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAP1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCTCCCTA
    RAP1A Expression
    About this image


    RAP1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    RAP1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAP1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.190334
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAP1A: 
              Telomeres & Telomerase in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Focal Adhesions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAP1A gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap1a1 , 5 RAS-related protein-1a1, 5 94.2(n)1
    100(a)1
      3 (46.45 cM)5
    1099051  NM_145541.51  NP_663516.11 
     1057282825 
    chicken
    (Gallus gallus)
    Aves RAP1A1 RAP1A, member of RAS oncogene family 91.49(n)
    99.46(a)
      419867  XM_417994.3  XP_417994.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAP1A6
    RAP1A, member of RAS oncogene family
    99(a)
    1 ↔ 1
    4(126538520-126592174)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238022 Xenopus laevis transcribed sequence with strong similarity more 85.5(n)    CD325556.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc66g062 Danio rerio, clone IMAGE5604882, mRNA 80.69(n)    BC049419.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta R1 , 3 photoreceptor commitment (sensu
    Drosophila) GTP more3
    Roughened1
    89(a)
    (best of 2)3
    72.13(n)1
    86.89(a)1
      3 62B73
    382441  NM_001202094.21  NP_001189023.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rrp-13 ras protein 89(a)
    (best of 3)
      IV(8916911-8918914)   --
    A. gossypii yeast
    (Ashbya gossypii)
    Saccharomycetes AGOS_AFR464W1 AGOS_AFR464W 59.28(n)
    61.08(a)
      4622288  NM_212147.1  NP_986011.1 


    ENSEMBL Gene Tree for RAP1A (if available)
    TreeFam Gene Tree for RAP1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAP1A gene
    RAP2C2  RASL10B2  DIRAS12  RAP1B2  RASD22  RIT22  RAP2A2  RIT12  
    RAP2B2  RASD12  DIRAS22  RASL10A2  DIRAS32  
    Selected SIMAP similar genes for RAP1A using alignment to 2 protein entries:     RAP1A_HUMAN (see all proteins) (see all similar genes):
    RAP1B    c-bas/has    RAP2A    DKFZp547A0616    HRAS    RAP2B
    RAP2C    RALA    NRAS    DIRAS1    KRAS    RALB
    MRAS    RRAS2    DIRAS2    RIT2    RIT1    RAB10

    Find genes that share paralogs with RAP1A           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RAP1A
    PGOHUM00000248230 PGOHUM00000250812


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAP1A (see all 2009)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821052811,2
    --112160434(+) GCCGAA/GGCGGG 2 -- us2k10--------
    rs1867528761,2
    --112160436(+) CGAGGA/CGGGTG 2 -- us2k10--------
    rs1896237361,2
    --112160465(+) ATTCGA/CGACCA 2 -- us2k10--------
    rs3704197751,2
    C--112160664(+) CGCCT-/AAAAAA 2 -- us2k10--------
    rs568620441,2
    C--112160676(+) AAAAA-/ATCATT 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1508678871,2
    --112160697(+) AAAATC/GAGAAA 2 -- us2k10--------
    rs729831951,2
    C,F--112160731(+) CCTCCC/TTTGAT 2 -- us2k12Minor allele frequency- T:0.06WA 120
    rs1393605851,2
    --112160745(+) AAGTAC/TCTCTC 2 -- us2k10--------
    rs795752211,2
    C,F--112160825(+) CCTCCC/TATCCT 2 -- us2k11Minor allele frequency- T:0.12WA 118
    rs1156093351,2
    C,F--112160963(+) CAGTAT/GCTGAT 2 -- us2k12Minor allele frequency- G:0.10WA NA 238

    HapMap Linkage Disequilibrium report for RAP1A (112084840 - 112259313 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RAP1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677467CNV Deletion23128226
    esv269684CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179520    OMIM disorders: --

    4 diseases for RAP1A:    
    About MalaCards
    leukocyte adhesion deficiency, type iii    lung adenoma    leukocyte adhesion deficiency    tuberous sclerosis


    Find genes that share disorders with RAP1A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RAP1A gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 50.3 2 7608212 (1), 12469204 (1)
    thyroid papillary carcinoma 29.8 2 18948674 (1)
    glanzmann thrombasthenia 25.9 1 10629034 (1)
    tumors 12.5 37 12469204 (3), 8084835 (2), 8890957 (2), 2142634 (1) (see all 21)
    myeloid leukemia 11.7 2 15982636 (1), 18180377 (1)
    granulomatous disease chronic 11.5 1 9731072 (1)
    myelodysplastic syndromes 5.94 1 16118622 (1)
    myeloid leukemia chronic 1.57 1 16076873 (1)
    melanoma 1.05 24 16186804 (6), 19147557 (4), 16912161 (3), 20484042 (1)
    azoospermia 0.389 1 15064832 (1)

    Genetic Association Database (GAD): RAP1A
    Human Genome Epidemiology (HuGE) Navigator: RAP1A (2 documents)

    Export disorders for RAP1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAP1A gene, integrated from 10 sources (see all 439):
    (articles sorted by number of sources associating them with RAP1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. (PubMed id 1899909)1, 2, 9 Buss J.E.... Der C.J. (Mol. Cell. Biol. 1991)
    2. RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation. (PubMed id 11359771)1, 2, 9 Liao Y....Kataoka T. (J. Biol. Chem. 2001)
    3. Mutation analysis of RAP1 gene in papillary thyroid carcinomas. (PubMed id 18948674)1, 4, 9 Matsuse M....Yamashita S. (Endocr. J. 2009)
    4. RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans. (PubMed id 10608844)1, 2, 9 Liao Y....Kataoka T. (J. Biol. Chem. 1999)
    5. The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. (PubMed id 7791872)1, 2, 9 Nassar N....Wittinghofer A. (Nature 1995)
    6. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. (PubMed id 20548944)1, 4 Hsu Y.H....Kiel D.P. (PLoS Genet. 2010)
    7. Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1. (PubMed id 17916086)1, 2 Beraud-Dufour S....Faurobert E. (FEBS J. 2007)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. (PubMed id 12444546)1, 2 Song C.... Kataoka T. (Oncogene 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5906 HGNC: 9855 AceView: RAP1A Ensembl:ENSG00000116473 euGenes: HUgn5906
    ECgene: RAP1A Kegg: 5906 H-InvDB: RAP1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RAP1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAP1A gene:
    Search GeneIP for patents involving RAP1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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