RAP1A Gene
protein-coding GIFtS: 68
GCID: GC01P112084
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|
RAP1A, member of RAS oncogene family
| |
Aliases
for RAP1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAP1A, Member Of RAS Oncogene Family1 2 | | GTP-Binding Protein Smg P21A2 3 | | KREV12 3 5 | | Ras-Related Protein Krev-12 3 | | KREV-11 2 | | RAP12 | | SMGP211 2 | | Ras-Related Protein Rap-1A2 | | C21KG2 3 | | RAS-Related Protein RAP1A2 | | G-22K2 3 | | |
Export aliases for RAP1A gene to outside databasesPrevious GC identifers: GC01P112501 GC01P110956 GC01P111186 GC01P111383 GC01P111796 GC01P111886 GC01P111963 GC01P110105 |
Summaries
for RAP1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAP1A:
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% aminoacid identity with the classical RAS proteins and have numerous structural features in common. The most strikingdifference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced bythreonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interactwith RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identifiedfor this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834Function: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenicfunction of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner
Gene Wiki entry for RAP1A
|
Genomic Views
for RAP1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAP1A gene promoter:
HSF1short HSF1 (long) FOXD3 Evi-1 RORalpha2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAP1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.3RAP1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P112084: view genomic region
(about GC identifiers)
Start:
|
112,084,840 bp from pter |
End:
|
112,259,313 bp from pter |
Size:
|
174,474 bases |
Orientation:
|
plus strand |
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Proteins
for RAP1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834 (See
protein sequence)Recommended Name: Ras-related protein Rap-1A precursor Size: 184 amino acids; 20987 Da
Subunit: In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3
Subcellular location: Cell membrane; Lipid-anchor
Sequence caution: Sequence=CAB55685.2; Type=Erroneous gene model prediction;
3 PDB 3D structures from  and Proteopedia  for RAP1A:1C1Y (3D)
1GUA (3D)
3KUC (3D)
Secondary accessions: P10113Explore the universe of human proteins at neXtProt for RAP1A: NX_P62834
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62834
RAP1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001010935.1 NP_002875.1
ENSEMBL proteins: ENSP00000348786 ENSP00000396741 ENSP00000358723 ENSP00000394318 ENSP00000443009 Reactome Protein details: P62834
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RAP1A for ontologies About GeneDecksing
RAP1A Antibody Products:
Assay Products for RAP1A: |
Protein
Domains /
Families
for RAP1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAP1A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62834ProtoNet protein and cluster: P62834 1 Blocks protein family: IPB003577 Ras small GTPase
UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834Similarity: Belongs to the small GTPase superfamily. Ras family |
Function
for RAP1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834Function: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenicfunction of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive mannerEnzyme regulation: Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner,and GFR Genatlas biochemistry entry for RAP1A:RAP1A,Ras oncogene superfamily member (Krev1),morphologic reversion of ras-transformed cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAP1A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAP1A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RAP1A (NM_002884) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAP1A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1A |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RAP1A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RAP1A:
Animal Models:
Mouse knock-out Rap1atm1Laaq for RAP1A
7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rap1a):
RAP1A for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAP1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/59 super-pathways (see all 59) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling_G-Protein alpha-i signaling cascades | | | 2 | Development HGF signaling pathway | | | 3 | Development Angiotensin activation of ERK | | | 4 | Development_A2B receptor- action via G-protein alpha s | | | 5 | GRB2:SOS provides linkage to MAPK signaling for Intergrins | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/24 EMD Millipore Pathways for RAP1A (see all 24)
5/20 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAP1A (see all 20)
2 
Cell Signaling Technology (CST) Pathways for RAP1A
5/24  GeneGo (Thomson Reuters) Pathways for RAP1A (see all 24)
5/16  BioSystems Pathways for RAP1A (see all 16)
5/23 
Reactome Pathways for RAP1A (see all 23)
1  PharmGKB Pathway for RAP1A
5/8 
Kegg Pathways (Kegg details for RAP1A) (see all 8):
RAP1A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAP1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/85 Interacting proteins for RAP1A (P628341, 2, 3 ENSP000003487864) via UniProtKB, MINT, STRING, and/or I2D (see all 85)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
RAP1A for ontologies About GeneDecksing
|
Drugs & Compounds
for RAP1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RAP1A for compounds About GeneDecksing
 Browse Tocris compounds for RAP1A
2 HMDB Compounds for RAP1A About this table
10/44 Novoseek chemical compound relationships for RAP1A gene (see all 44) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gtp |
71.2 |
55 |
12473665 (4), 2160589 (3), 10608844 (2), 1939245 (2) (see all 32) |
| gdp |
66.9 |
18 |
10608844 (2), 2110451 (2), 11292831 (1), 20170508 (1) (see all 13) |
| guanosine |
59.2 |
7 |
15613546 (1), 17954608 (1), 18362184 (1), 16043520 (1) (see all 6) |
| forskolin |
56.6 |
18 |
10908723 (4), 15345481 (1), 15601837 (1), 12464615 (1) (see all 12) |
| cyclic amp |
53.7 |
45 |
16507992 (6), 15546918 (3), 15591041 (3), 14985123 (3) (see all 16) |
| geranylgeranyl pyrophosphate |
53.2 |
2 |
12427032 (1), 17640631 (1) |
| tyrosine |
52.9 |
33 |
16170364 (2), 18789886 (2), 15982636 (2), 16182283 (2) (see all 22) |
| mevalonate |
46.3 |
3 |
12427032 (2), 11788600 (1), 17640631 (1) |
| perillyl alcohol |
44.2 |
1 |
9296357 (1) |
| guanine |
35.4 |
5 |
17383543 (1), 16681758 (1), 17993260 (1), 18039662 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about RAP1A
|
Transcripts
for RAP1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAP1A gene (2 alternative transcripts): NM_001010935.1 NM_002884.2 Unigene Cluster for RAP1A: RAP1A, member of RAS oncogene family Hs.190334 [show with all ESTs]Unigene Representative Sequence: NM_0010109356 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000356415 ENST00000433097 ENST00000369709(uc001ebl.3) ENST00000494982
ENST00000436150(uc001ebi.3 uc001ebk.3) ENST00000545460
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAP1A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAP1A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RAP1A (NM_002884) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAP1A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1A |
Additional cDNA sequence: AB451235.1 AB451360.1 AF493912.1 AK293044.1 BC014086.2 BT019666.1 M22995.1 X12533.1 13 DOTS entries: DT.70101779 DT.100800672 DT.451930 DT.100800671 DT.121382734 DT.100800680 DT.95243672 DT.100028709 DT.99996642 DT.100800674 DT.100800676 DT.120749171 DT.75108365 24/389 AceView cDNA sequences (see all 389): BI856433 T53557 AV659417 CR597469 AA383199 AA628171 BM759422 BI493639 BG612316 AA059264 X12533 R37585 BQ269560 BU150941 CA414041 BU677958 CA421524 AA365910 CA774853 AA437308 BQ009973 CR623933 AF493912 CD365553
GeneLoc Exon Structure
|
Expression
for RAP1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAP1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCCTCCCTA
About this image
See RAP1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAP1A
SOURCE GeneReport for Unigene cluster: Hs.190334
SABiosciences Expression via Pathway-Focused PCR Arrays including RAP1A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAP1A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAP1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAP1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP1A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1A |
Orthologs
for RAP1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RAP1A gene from 6/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RAP1A1 |
RAP1A, member of RAS oncogene family |
91.49(n)
99.46(a) |
|
419867 XM_417994.2 XP_417994.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RAP1A6 |
-- |
99(a) |
1 ↔ 1 |
4(126561165-126584626) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.238022 |
Xenopus laevis transcribed sequence with strong similarity more |
85.5(n) |
|
CD325556.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc66g062 |
Danio rerio, clone IMAGE5604882, mRNA |
80.69(n) |
|
BC049419.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
R1 , 3 |
photoreceptor commitment (sensu Drosophila)
GTP more3
Roughened1 |
89(a)
(best of 2)3
72.86(n)1
87.43(a)1 |
|
3 62B73
382441 NM_001202094.11 NP_001189023.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
rrp-13
rap-11 |
ras protein3
Protein RAP-11 |
89(a)
(best of 3)3
73.96(n)1
89.94(a)1 |
|
IV(8916911-8918914)3
1777091 NM_069148.31 NP_501549.11 |
ENSEMBL Gene Tree for RAP1A (if available)
TreeFam Gene Tree for RAP1A (if available) |
Paralogs
for RAP1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAP1A gene
- RAP2C2 RASL10B2 DIRAS12 RAP1B2 RASD22 RAP2A2 RAP2B2 RASD12
- DIRAS22 RASL10A2 DIRAS32
18/105 SIMAP similar genes for RAP1A using alignment to 2 protein entries: RAP1A_HUMAN (see all proteins)
(see all similar genes):RAP1B c-bas/has RAP2A DKFZp547A0616 HRAS RAP2B
RAP2C RALA NRAS DIRAS1 KRAS RALB
MRAS RRAS2 DIRAS2 RIT2 RIT1 RAB10
RAP1A for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RAP1A
PGOHUM00000248230 PGOHUM00000250812
|
Genomic Variants
for RAP1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAP1A (112084840 - 112259313 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RAP1A
2 CNVs: 74647 84474 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAP1A |
|
Disorders
/ Diseases
for RAP1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAP1A for disorders About GeneDecksing
OMIM gene information: 179520
OMIM disorders: --
20/44  diseases for RAP1A (see all 44): About MalaCardsleukocyte adhesion deficiency, type iii glanzmann's thrombasthenia thrombasthenia tuberous sclerosis
myeloproliferative disorder myeloid leukemia cervical squamous cell carcinoma squamous cell carcinoma
babesiosis bipolar disorder myelodysplastic syndrome pulmonary emphysema
papillary thyroid carcinoma rheumatoid arthritis acute myeloid leukemia follicular adenoma
emphysema azoospermia renal cell carcinoma thyroid carcinoma
10/24 Novoseek disease relationships for RAP1A gene (see all 24) About this table
Human Genome Epidemiology (HuGE) Navigator: RAP1A (2 documents)
Export disorders for RAP1A gene to outside databases
|
Publications
for RAP1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAP1A gene, integrated from 9 sources (see all 413):
(articles sorted by number of sources associating them with RAP1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. (PubMed id 1899909)1, 2, 9 Buss J.E.... Der C.J. (1991)
- The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. (PubMed id 7791872)1, 2, 9 Nassar N....Wittinghofer A. (1995)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. (PubMed id 12444546)1, 2 Song C.... Kataoka T. (2002)
- Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. (PubMed id 11022048)1, 2 Song C.... Kataoka T. (2001)
- Ras/Rap effector specificity determined by charge reversal. (PubMed id 8756332)1, 2 Nassar N....Wittinghofer A. (1996)
- Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein. (PubMed id 2507536)1, 2 Nagata K....Nozawa Y. (1989)
- Identification of a platelet Mr 22,000 GTP-binding protein as the novel smg-21 gene product having the same putative effector domain as the ras gene products. (PubMed id 3144274)1, 2 Ohmori T.... Takai Y. (1988)
- Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. (PubMed id 3045729)1, 2 Pizon V.... Tavitian A. (1988)
|
External Searches for RAP1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAP1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAP1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAP1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAP1A gene:
Search GeneIP for patents involving RAP1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RAP1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for RAP1A | | OriGene shRNA RFP for RAP1A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAP1A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAP1A | | | OriGene Protein Over-expression Lysate for RAP1A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAP1A | | OriGene 3'-UTR Clone for RAP1A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAP1A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAP1A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RAP1A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAP1A | | OriGene Custom Protein Services for RAP1A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAP1A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAP1A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP1A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAP1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAP1A |
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| | Antibodies & Assays for RAP1A |
| | | | Search Tocris compounds for RAP1A |
| |  |  |  |  | | | | | | Recombinant Protein for RAP1A |
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 | | | RAP1A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAP1A |
|  |  |  | | | | ThermoFisher Antibodies for RAP1A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1A |
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