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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAP1A Gene

protein-coding   GIFtS: 69
GCID: GC01P112084

RAP1A, Member Of RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAP1A, Member Of RAS Oncogene Family1 2     KREV-12
KREV12 3 5     RAP12
C21KG2 3     SMGP212
G-22K2 3     Ras-Related Protein Rap-1A2
GTP-Binding Protein Smg P21A2 3     RAS-Related Protein RAP1A2
Ras-Related Protein Krev-12 3     

External Ids:    HGNC: 98551   Entrez Gene: 59062   Ensembl: ENSG000001164737   OMIM: 1795205   UniProtKB: P628343   

Export aliases for RAP1A gene to outside databases

Previous GC identifers: GC01P112501 GC01P110956 GC01P111186 GC01P111383 GC01P111796 GC01P111886 GC01P111963 GC01P110105


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAP1A Gene:
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50%
amino acid identity with the classical RAS proteins and have numerous structural features in common. The most
striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is
replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because
it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein
have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAP1A Gene: 
RAP1A (RAP1A, member of RAS oncogene family) is a protein-coding gene. Diseases associated with RAP1A include leukocyte adhesion deficiency, type iii, and leukocyte adhesion deficiency, and among its related super-pathways are Development HGF signaling pathway and Integrin-mediated cell adhesion. GO annotations related to this gene include GTP binding and Ras GTPase binding. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834
Function: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic
function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together
with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes

Gene Wiki entry for RAP1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAP1A gene promoter:
         HSF1short   HSF1 (long)   FOXD3   Evi-1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAP1A promoter sequence
   Search SABiosciences Chromatin IP Primers for RAP1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAP1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.3

RAP1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAP1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P112084:  view genomic region     (about GC identifiers)

Start:
112,084,840 bp from pter      End:
112,259,313 bp from pter
Size:
174,474 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834 (See protein sequence)
Recommended Name: Ras-related protein Rap-1A precursor  
Size: 184 amino acids; 20987 Da
Subunit: Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form
preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation
of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3
Subcellular location: Cell membrane; Lipid-anchor
Sequence caution: Sequence=CAB55685.2; Type=Erroneous gene model prediction;
3 PDB 3D structures from and Proteopedia for RAP1A:
1C1Y (3D)        1GUA (3D)        3KUC (3D)    
Secondary accessions: P10113

Explore the universe of human proteins at neXtProt for RAP1A: NX_P62834

Explore proteomics data for RAP1A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62834

  • RAP1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAP1A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001010935.1  NP_002875.1  

    ENSEMBL proteins: 
     ENSP00000348786   ENSP00000396741   ENSP00000358723   ENSP00000394318   ENSP00000443009  
    Reactome Protein details: P62834
    Human Recombinant Protein Products for RAP1A: 
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    Novus Biologicals RAP1A Proteins
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    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for RAP1A
    Cloud-Clone Corp. Proteins for RAP1A 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11359771
    GO:0005769early endosome ISS--
    GO:0005770late endosome ISS--
    GO:0005829cytosol TAS--

    RAP1A for ontologies           About GeneDecksing



    RAP1A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P62834

    ProtoNet protein and cluster: P62834

    1 Blocks protein domain: IPB003577 Ras small GTPase

    UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RAP1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAP1A_HUMAN, P62834
    Function: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic
    function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together
    with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes
    Enzyme regulation: Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent
    manner, and GFR

         Genatlas biochemistry entry for RAP1A:
    RAP1A,Ras oncogene superfamily member (Krev1),morphologic reversion of ras-transformed cells

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI10608844
    GO:0005525GTP binding IEA--
    GO:0008565protein transporter activity IDA17916086
    GO:0017016Ras GTPase binding IEA--
         
    RAP1A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RAP1A:
     Synthetic lethal with c-Myc af  Synthetic lethal with imatinib 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rap1a):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  immune system 
     mortality/aging  nervous system 

    RAP1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rap1atm1Laaq for RAP1A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAP1A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAP1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAP1A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAP1A 

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    SwitchGear 3'UTR luciferase reporter plasmidRAP1A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAP1A About   (see all 60)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Development Neurotrophin family signaling0.45
    Renal cell carcinoma0.30
    Neurotrophin signaling pathway0.36
    2Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    5Development Angiotensin activation of ERK
    Development ACM2 and ACM4 activation of ERK0.74
    Development EDNRB signaling0.54
    Development G-Proteins mediated regulation MARK-ERK signaling0.66
    Development EPO-induced MAPK pathway0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/24 EMD Millipore Pathways for RAP1A (see all 24)
        Cytoskeleton remodeling FAK signaling
    G-protein signaling G-Protein alpha-12 signaling pathway
    G-protein signaling Ras family GTPases in kinase cascades (scheme)
    G-protein signaling G-Protein alpha-s signaling cascades
    Development G-Proteins mediated regulation MARK-ERK signaling

    5/20 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAP1A (see all 20)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    TRKA Signaling

    2 Cell Signaling Technology (CST) Pathways for RAP1A
        Cytoskeletal Signaling
    Adhesion

    5/24 GeneGo (Thomson Reuters) Pathways for RAP1A (see all 24)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    G-protein signaling G-Protein alpha-i signaling cascades
    G-protein signaling TC21 regulation pathway
    Development Beta-adrenergic receptors regulation of ERK

    5/17 BioSystems Pathways for RAP1A (see all 17)
        MAPK signaling pathway
    Focal Adhesion
    Serotonin Receptor 4/6/7 and NR3C Signaling
    Integrin-mediated cell adhesion
    Integrated Breast Cancer Pathway

    5/21        Reactome Pathways for RAP1A (see all 21)
        Metabolism
    Regulation of Insulin Secretion
    GRB2:SOS provides linkage to MAPK signaling for Intergrins
    Signal Transduction
    Signalling by NGF

    1 PharmGKB Pathway for RAP1A
        Bisphosphonate Pathway, Pharmacodynamics

    5/8         Kegg Pathways  (Kegg details for RAP1A) (see all 8):
        MAPK signaling pathway
    Chemokine signaling pathway
    Focal adhesion
    Leukocyte transendothelial migration
    Long-term potentiation


    RAP1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAP1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/93 Interacting proteins for RAP1A (P628341, 2, 3 ENSP000003487864) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity TAS--
    GO:0006112energy reserve metabolic process TAS--
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----

    RAP1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAP1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAP1A

    2 HMDB Compounds for RAP1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    10/44 Novoseek inferred chemical compound relationships for RAP1A gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 71.2 55 12473665 (4), 2160589 (3), 10608844 (2), 1939245 (2) (see all 32)
    gdp 66.9 18 10608844 (2), 2110451 (2), 11292831 (1), 20170508 (1) (see all 13)
    guanosine 59.2 7 15613546 (1), 17954608 (1), 18362184 (1), 16043520 (1) (see all 6)
    forskolin 56.6 18 10908723 (4), 15345481 (1), 15601837 (1), 12464615 (1) (see all 12)
    cyclic amp 53.7 45 16507992 (6), 15546918 (3), 15591041 (3), 14985123 (3) (see all 16)
    geranylgeranyl pyrophosphate 53.2 2 12427032 (1), 17640631 (1)
    tyrosine 52.9 33 16170364 (2), 18789886 (2), 15982636 (2), 16182283 (2) (see all 22)
    mevalonate 46.3 3 12427032 (2), 11788600 (1), 17640631 (1)
    perillyl alcohol 44.2 1 9296357 (1)
    guanine 35.4 5 17383543 (1), 16681758 (1), 17993260 (1), 18039662 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about RAP1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAP1A gene (2 alternative transcripts): 
    NM_001010935.1  NM_002884.2  

    Unigene Cluster for RAP1A:

    RAP1A, member of RAS oncogene family
    Hs.190334  [show with all ESTs]
    Unigene Representative Sequence: NM_001010935
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356415 ENST00000433097 ENST00000369709(uc001ebl.3) ENST00000494982
    ENST00000436150(uc001ebi.3 uc001ebk.3) ENST00000545460
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAP1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAP1A
    Sirion Biotech Customized lentivirus for stable overexpression of RAP1A 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAP1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAP1A

    Additional mRNA sequence: 

    AB451235.1 AB451360.1 AF493912.1 AK293044.1 BC014086.2 BT019666.1 M22995.1 X12533.1 

    13 DOTS entries:

    DT.70101779  DT.100800672  DT.451930  DT.100800671  DT.121382734  DT.100800680  DT.95243672  DT.100028709 
    DT.99996642  DT.100800674  DT.100800676  DT.120749171  DT.75108365 

    24/389 AceView cDNA sequences (see all 389):

    AA365910 BQ015322 CA774853 T53557 T53553 BI856433 BG231927 CR597469 
    BU678082 BU150941 BG620014 CA446565 R37585 BG612316 CA421524 BQ007820 
    BQ638200 CB136067 BQ186989 BQ722841 BI493639 CD108761 BM752342 AV659417 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAP1A expression in normal human tissues (normalized intensities)      RAP1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCTCCCTA
    RAP1A Expression
    About this image


    RAP1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
             Olfactory Bulb   
     
     Blood (Hematopoietic System)
             platelets   

    See RAP1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAP1A

    SOURCE GeneReport for Unigene cluster: Hs.190334
        SABiosciences Expression via Pathway-Focused PCR Arrays including RAP1A: 
              Telomeres & Telomerase in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Focal Adhesions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAP1A gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rap1a1 , 5 RAS-related protein-1a1, 5 94.2(n)1
    100(a)1
      3 (46.45 cM)5
    1099051  NM_145541.41  NP_663516.11 
     1057282825 
    chicken
    (Gallus gallus)
    Aves RAP1A1 RAP1A, member of RAS oncogene family 91.49(n)
    99.46(a)
      419867  XM_417994.2  XP_417994.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAP1A6
    Uncharacterized protein
    99(a)
    1 ↔ 1
    4(126538520-126592174)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238022 Xenopus laevis transcribed sequence with strong similarity more 85.5(n)    CD325556.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc66g062 Danio rerio, clone IMAGE5604882, mRNA 80.69(n)    BC049419.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta R1 , 3 photoreceptor commitment (sensu
    Drosophila) GTP more3
    Roughened1
    89(a)
    (best of 2)3
    72.86(n)1
    87.43(a)1
      3 62B73
    382441  NM_001202094.11  NP_001189023.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rrp-13
    rap-11
    ras protein3
    Protein RAP-11
    89(a)
    (best of 3)3
    73.96(n)1
    89.94(a)1
      IV(8916911-8918914)3
    1777091  NM_069148.31  NP_501549.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSR1(YGR152C)4 GTP-binding protein of the ras superfamily required more   --   7(795492-794674) 853056  NP_011668.1 


    ENSEMBL Gene Tree for RAP1A (if available)
    TreeFam Gene Tree for RAP1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAP1A gene
    RAP2C2  DIRAS12  RAP1B2  RALA2  RIT22  RAP2A2  RIT12  RALB2  
    RAP2B2  NRAS2  DIRAS22  KRAS2  HRAS2  DIRAS32  
    18/102 SIMAP similar genes for RAP1A using alignment to 2 protein entries:     RAP1A_HUMAN (see all proteins) (see all similar genes):
    RAP1B    c-bas/has    RAP2A    DKFZp547A0616    HRAS    RAP2B
    RAP2C    RALA    NRAS    DIRAS1    KRAS    RALB
    MRAS    RRAS2    DIRAS2    RIT2    RIT1    RAB10

    RAP1A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RAP1A
    PGOHUM00000248230 PGOHUM00000250812


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2009 SNPs in RAP1A are shown (see all 2009)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821052811,2
    --112160434(+) GCCGAA/GGCGGG 2 -- us2k10--------
    rs1867528761,2
    --112160436(+) CGAGGA/CGGGTG 2 -- us2k10--------
    rs1896237361,2
    --112160465(+) ATTCGA/CGACCA 2 -- us2k10--------
    rs3704197751,2
    C--112160664(+) CGCCT-/AAAAAA 2 -- us2k10--------
    rs568620441,2
    C--112160676(+) AAAAA-/ATCATT 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1508678871,2
    --112160697(+) AAAATC/GAGAAA 2 -- us2k10--------
    rs729831951,2
    C,F--112160731(+) CCTCCC/TTTGAT 2 -- us2k12Minor allele frequency- T:0.06WA 120
    rs1393605851,2
    --112160745(+) AAGTAC/TCTCTC 2 -- us2k10--------
    rs795752211,2
    C,F--112160825(+) CCTCCC/TATCCT 2 -- us2k11Minor allele frequency- T:0.12WA 118
    rs1156093351,2
    C,F--112160963(+) CAGTAT/GCTGAT 2 -- us2k12Minor allele frequency- G:0.10WA NA 238

    HapMap Linkage Disequilibrium report for RAP1A (112084840 - 112259313 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RAP1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677467CNV Deletion23128226
    esv269684CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179520    OMIM disorders: --

    20/45 diseases for RAP1A (see all 45):    About MalaCards
    leukocyte adhesion deficiency, type iii    leukocyte adhesion deficiency    lung adenoma    babesiosis
    follicular adenoma    thrombasthenia    glanzmann's thrombasthenia    tuberous sclerosis
    tuberous sclerosis complex    vesiculitis    pulmonary emphysema    azoospermia
    cervical squamous cell carcinoma    bipolar disorder    myelodysplastic syndromes    papillary thyroid carcinoma
    papillary carcinoma    neurofibromatosis    myeloid leukemia    astrocytoma


    RAP1A for disorders           About GeneDecksing

    10/24 Novoseek inferred disease relationships for RAP1A gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tuberous sclerosis 50.3 2 7608212 (1), 12469204 (1)
    thyroid papillary carcinoma 29.8 2 18948674 (1)
    glanzmann thrombasthenia 25.9 1 10629034 (1)
    tumors 12.5 37 12469204 (3), 8084835 (2), 8890957 (2), 2142634 (1) (see all 21)
    myeloid leukemia 11.7 2 15982636 (1), 18180377 (1)
    granulomatous disease chronic 11.5 1 9731072 (1)
    myelodysplastic syndromes 5.94 1 16118622 (1)
    myeloid leukemia chronic 1.57 1 16076873 (1)
    melanoma 1.05 24 16186804 (6), 19147557 (4), 16912161 (3), 20484042 (1)
    azoospermia 0.389 1 15064832 (1)

    Genetic Association Database (GAD): RAP1A
    Human Genome Epidemiology (HuGE) Navigator: RAP1A (2 documents)

    Export disorders for RAP1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAP1A gene, integrated from 9 sources (see all 437):
    (articles sorted by number of sources associating them with RAP1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. (PubMed id 1899909)1, 2, 9 Buss J.E.... Der C.J. (1991)
    2. Mutation Analysis of RAP1 Gene in Papillary Thyroid Carcinomas. (PubMed id 18948674)1, 4, 9 Matsuse M....Yamashita S. (2008)
    3. The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. (PubMed id 7791872)1, 2, 9 Nassar N....Wittinghofer A. (1995)
    4. An integration of genome-wide association study and g ene expression profiling to prioritize the discovery of novel susceptibility Lo ci for osteoporosis-related traits. (PubMed id 20548944)1, 4 Hsu Y.H....Kiel D.P. (2010)
    5. Krit 1 interactions with microtubules and membranes ar e regulated by Rap1 and integrin cytoplasmic domain associated protein-1. (PubMed id 17916086)1, 2 Beraud-Dufour S....Faurobert E. (2007)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. (PubMed id 12444546)1, 2 Song C.... Kataoka T. (2002)
    9. Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. (PubMed id 11022048)1, 2 Song C.... Kataoka T. (2001)
    10. Ras/Rap effector specificity determined by charge reversal. (PubMed id 8756332)1, 2 Nassar N....Wittinghofer A. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5906 HGNC: 9855 AceView: RAP1A Ensembl:ENSG00000116473 euGenes: HUgn5906
    ECgene: RAP1A Kegg: 5906 H-InvDB: RAP1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAP1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAP1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAP1A gene:
    Search GeneIP for patents involving RAP1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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