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Aliases for RAP1A Gene

Aliases for RAP1A Gene

  • RAP1A, Member Of RAS Oncogene Family 2 3 5
  • GTP-Binding Protein Smg P21A 3 4
  • Ras-Related Protein Krev-1 3 4
  • C21KG 3 4
  • G-22K 3 4
  • KREV1 3 4
  • KREV-1 3
  • SMGP21 3
  • RAP1 3

External Ids for RAP1A Gene

Previous GeneCards Identifiers for RAP1A Gene

  • GC01P112501
  • GC01P110956
  • GC01P111186
  • GC01P111383
  • GC01P111796
  • GC01P111886
  • GC01P111963
  • GC01P112084
  • GC01P110105

Summaries for RAP1A Gene

Entrez Gene Summary for RAP1A Gene

  • This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for RAP1A Gene

RAP1A (RAP1A, Member Of RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAP1A include kabuki syndrome 1 and leukocyte adhesion deficiency, type iii. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include GTP binding and protein complex binding. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for RAP1A Gene

  • Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

Gene Wiki entry for RAP1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP1A Gene

Genomics for RAP1A Gene

Regulatory Elements for RAP1A Gene

Genomic Location for RAP1A Gene

Chromosome:
1
Start:
111,542,218 bp from pter
End:
111,716,695 bp from pter
Size:
174,478 bases
Orientation:
Plus strand

Genomic View for RAP1A Gene

Genes around RAP1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAP1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP1A Gene

Proteins for RAP1A Gene

  • Protein details for RAP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62834-RAP1A_HUMAN
    Recommended name:
    Ras-related protein Rap-1A
    Protein Accession:
    P62834
    Secondary Accessions:
    • P10113

    Protein attributes for RAP1A Gene

    Size:
    184 amino acids
    Molecular mass:
    20987 Da
    Quaternary structure:
    • Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain).
    SequenceCaution:
    • Sequence=CAB55685.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAP1A Gene

neXtProt entry for RAP1A Gene

Proteomics data for RAP1A Gene at MOPED

Post-translational modifications for RAP1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAP1A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAP1A (RAP1A)

No data available for DME Specific Peptides for RAP1A Gene

Domains & Families for RAP1A Gene

Gene Families for RAP1A Gene

Protein Domains for RAP1A Gene

Graphical View of Domain Structure for InterPro Entry

P62834

UniProtKB/Swiss-Prot:

RAP1A_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RAP1A: view

Function for RAP1A Gene

Molecular function for RAP1A Gene

GENATLAS Biochemistry:
RAP1A,Ras oncogene superfamily member (Krev1),morphologic reversion of ras-transformed cells
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR.
UniProtKB/Swiss-Prot Function:
Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
genes like me logo Genes that share phenotypes with RAP1A: view

Animal Models for RAP1A Gene

MGI Knock Outs for RAP1A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAP1A Gene

Localization for RAP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP1A Gene

Cell membrane; Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Early endosome. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAP1A Gene COMPARTMENTS Subcellular localization image for RAP1A gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
plasma membrane 5
cytoskeleton 2
nucleus 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005769 early endosome IEA,ISS --
GO:0030054 cell junction IEA,ISS --
genes like me logo Genes that share ontologies with RAP1A: view

Pathways & Interactions for RAP1A Gene

SuperPathways for RAP1A Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Development HGF signaling pathway
3 Focal Adhesion
4 Development Angiotensin activation of ERK
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with RAP1A: view

Gene Ontology (GO) - Biological Process for RAP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006886 intracellular protein transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0030033 NOT microvillus assembly IMP 22797597
genes like me logo Genes that share ontologies with RAP1A: view

No data available for SIGNOR curated interactions for RAP1A Gene

Drugs & Compounds for RAP1A Gene

(27) Drugs for RAP1A Gene - From: Novoseek, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Kobe0065 Pharma Ras inhibitor 0
kobe2602 Pharma Ras inhibitor 0
Salirasib Pharma Inhibitor of active Ras protein 0

(21) Additional Compounds for RAP1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for RAP1A Gene

Compound Action Cas Number
Kobe0065 Ras inhibitor 436133-68-5
kobe2602 Ras inhibitor 454453-49-7
Salirasib Inhibitor of active Ras protein 162520-00-5
genes like me logo Genes that share compounds with RAP1A: view

Transcripts for RAP1A Gene

Unigene Clusters for RAP1A Gene

RAP1A, member of RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAP1A Gene

No ASD Table

Relevant External Links for RAP1A Gene

GeneLoc Exon Structure for
RAP1A
ECgene alternative splicing isoforms for
RAP1A

Expression for RAP1A Gene

mRNA expression in normal human tissues for RAP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAP1A Gene

This gene is overexpressed in Adipocyte (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAP1A Gene



SOURCE GeneReport for Unigene cluster for RAP1A Gene Hs.190334

genes like me logo Genes that share expression patterns with RAP1A: view

Protein tissue co-expression partners for RAP1A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAP1A Gene

Orthologs for RAP1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAP1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAP1A 35
  • 95.83 (n)
  • 100 (a)
RAP1A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAP1A 35
  • 96.74 (n)
  • 100 (a)
RAP1A 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rap1a 35
  • 94.2 (n)
  • 100 (a)
Rap1a 16
Rap1a 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAP1A 35
  • 100 (n)
  • 100 (a)
RAP1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rap1a 35
  • 95.65 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 100 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RAP1A 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAP1A 35
  • 91.49 (n)
  • 99.46 (a)
RAP1A 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAP1A 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rap1a 35
  • 84.06 (n)
  • 97.28 (a)
Str.17139 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23802 35
zebrafish
(Danio rerio)
Actinopterygii rap1aa 35
  • 81.88 (n)
  • 96.74 (a)
wufc66g06 35
rap1aa 36
  • 95 (a)
ManyToMany
rap1ab 36
  • 95 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9072 35
fruit fly
(Drosophila melanogaster)
Insecta R 37
  • 89 (a)
Rap2l 37
  • 56 (a)
R 35
  • 72.13 (n)
  • 86.89 (a)
R 36
  • 86 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001874 35
  • 71.77 (n)
  • 86.89 (a)
worm
(Caenorhabditis elegans)
Secernentea C08F8.7 37
  • 49 (a)
C25D7.7 37
  • 53 (a)
rrp-1 37
  • 89 (a)
rap-1 36
  • 82 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR464W 35
  • 59.28 (n)
  • 61.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU02167 35
  • 57.75 (n)
  • 57.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8837 36
  • 83 (a)
OneToMany
Species with no ortholog for RAP1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP1A Gene

ENSEMBL:
Gene Tree for RAP1A (if available)
TreeFam:
Gene Tree for RAP1A (if available)

Paralogs for RAP1A Gene

Pseudogenes.org Pseudogenes for RAP1A Gene

genes like me logo Genes that share paralogs with RAP1A: view

Variants for RAP1A Gene

Sequence variations from dbSNP and Humsavar for RAP1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6573 -- 111,712,767(+) ATCCT(A/C)CCTAT nc-transcript-variant, utr-variant-3-prime
rs13059 -- 111,655,204(-) TTCCC(A/G)TGGTC intron-variant
rs480578 -- 111,709,839(+) tatca(A/G)tagtt intron-variant
rs490011 -- 111,619,407(-) tcttg(C/G)agctt upstream-variant-2KB
rs506070 -- 111,691,446(+) CTGAT(A/T)AATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAP1A Gene

Variant ID Type Subtype PubMed ID
esv269684 CNV Insertion 20981092
esv2677467 CNV Deletion 23128226

Variation tolerance for RAP1A Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAP1A Gene

HapMap Linkage Disequilibrium report
RAP1A
Human Gene Mutation Database (HGMD)
RAP1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAP1A Gene

Disorders for RAP1A Gene

MalaCards: The human disease database

(8) MalaCards diseases for RAP1A Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kabuki syndrome 1
  • kabuki syndrome
leukocyte adhesion deficiency, type iii
  • leukocyte adhesion deficiency, type 3
babesiosis
  • babesiasis
tuberous sclerosis
  • bourneville's disease
joint disorders
  • arthropathy
- elite association - COSMIC cancer census association via MalaCards
Search RAP1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAP1A

Genetic Association Database (GAD)
RAP1A
Human Genome Epidemiology (HuGE) Navigator
RAP1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAP1A
genes like me logo Genes that share disorders with RAP1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAP1A Gene

Publications for RAP1A Gene

  1. The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. (PMID: 1899909) Buss J.E. … Der C.J. (Mol. Cell. Biol. 1991) 3 4 23 67
  2. Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis. (PMID: 18805968) Carmona G. … Chavakis E. (Blood 2009) 3 23
  3. Mutation analysis of RAP1 gene in papillary thyroid carcinomas. (PMID: 18948674) Matsuse M. … Yamashita S. (Endocr. J. 2009) 3 23
  4. Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration. (PMID: 19176753) Severson E.A. … Parkos C.A. (Mol. Biol. Cell 2009) 3 23
  5. Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA. (PMID: 19464664) Kojima F. … Crofford L.J. (Prostaglandins Other Lipid Mediat. 2009) 3 23

Products for RAP1A Gene

Sources for RAP1A Gene

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