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RAP1A Gene

protein-coding GIFtS: 68

GC01P111886

RAP1A, member of RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C21KG ^³
G-22K ^³
KREV-1 ^¹, ²
KREV1 ^², ³, ⁵
OTTHUMP00000013740 ^²
OTTHUMP00000013741 ^²
OTTHUMP00000059089 ^²
RAP1 ^²
SMGP21 ^¹, ²

Descriptions
GTP-binding protein smg-p21A ^³
RAP1A, member of RAS oncogene family ^²
RAS-related protein RAP1A ^²
Ras-related protein Krev-1 ^², ³
Ras-related protein Rap-1A ^²

External Ids
HGNC: 9855¹
Entrez Gene: 5906²
UniProtKB: P62834³
Ensembl: ENSG00000116473⁷

Search outside databases for aliases for RAP1A gene

Previous GC identifers: GC01P112501 GC01P110956 GC01P111186 GC01P111383 GC01P111796

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RAP1A:

The product of this gene belongs to the family of RAS-related proteins. These proteins share

approximately 50% amino acid identity with the classical RAS proteins and have numerous structural

features in common. The most striking difference between RAP proteins and RAS proteins resides in

their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of

this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF

in a competitive manner. Two transcript variants encoding the same protein have been identified

for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834

Function: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts

the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a

competitive manner

Gene Wiki entry for RAP1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RAP1A gene

Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.3

RAP1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P111886: (about GC identifiers)

Start:	111,886,363 bp from pter
End:	112,057,624 bp from pter
Size:	171,262 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834 (See protein sequence)

Recommended Name: Ras-related protein Rap-1A precursor

Size: 184 amino acids; 20987 Da

Subunit: In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and

SGSM3

Subcellular location: Cell membrane; Lipid-anchor

Sequence caution: Sequence=CAB55685.2; Type=Erroneous gene model prediction;

PDB structure from and Proteopedia :

1C1Y (3D)

1GUA (3D)

Secondary accessions: P10113

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001010935.1 NP_002875.1

ENSEMBL proteins:

ENSP00000358723 ENSP00000348786

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for RAP1A
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RAP1A + RAP1B)
	Human Recombinant Proteins from Abnova (RAP1A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005829	cytosol	EXP	16284401
GO:0005886	plasma membrane	IEA	--
GO:0032045	guanyl-nucleotide exchange factor complex	IEA	--

About this table

Antibodies for RAP1A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RAP1A
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for RAP1A (Rap1)
	Antibodies from Abcam (RAP1A + RAP1B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RAP1A)
	Novus Biologicals Antibodies for RAP1A

Assays for RAP1A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P62834

ProtoNet protein and cluster: P62834

1 Blocks protein family: IPB003577 Ras small GTPase

UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834

Similarity: Belongs to the small GTPase superfamily. Ras family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAP1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAP1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001010935

Applied Biosystems Silencer® siRNAs for RAP1A

Sigma-Aldrich siRNA and siRNA Panels for RAP1A

Sigma-Aldrich shRNA for RAP1A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001010935
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001010935
untagged cDNA clones in CMV expression vector (see all 2): NM_001010935

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001010935

UniProtKB/Swiss-Prot: RAP1A_HUMAN, P62834

Function: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts

the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a

competitive manner

Enzyme regulation: Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a

cAMP-dependent manner, and GFR

Genatlas biochemistry entry for RAP1A:

RAP1A,Ras oncogene superfamily member (Krev1),morphologic reversion of ras-transformed cells

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rap1a):

	behavior/neurological	hematopoietic system	immune system	lethality-prenatal/perinatal
nervous system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	TAS	10777492
GO:0005515	protein binding	IPI	11022048
GO:0005525	GTP binding	IEA	--
GO:0017016	Ras GTPase binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/14 Sigma-Aldrich "Your Favorite Gene" Pathways for RAP1A (Your Favorite Gene powered by Ingenuity) (see all 14 )

Ephrin Receptor Signaling
Relaxin Signaling
HGF Signaling
Renal Cell Carcinoma Signaling
Leukocyte Extravasation Signaling

GeneDecks RAP1A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RAP1A

5/103 Interacting proteins for RAP1A (ENSP00000348786³ P62834^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 103 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RASSF5	Q8WWW0¹	STRING (score=.974) EBI-491414, EBI-367390
RAF1	P04049¹^,²	STRING (score=.999) EBI-491414, EBI-365996 MINT-24923 EBI-491414, EBI-365996 MINT-24923
Rabac1 Rabac1 (xeno)	Q9Z0S9¹	EBI-491414, EBI-476965
Rassf5 Rassf5 (xeno)	Q5EBH1¹	EBI-491414, EBI-960530
RAF1	P04049¹^,²	STRING (score=.999) EBI-491414, EBI-365996 MINT-24923 EBI-491414, EBI-365996 MINT-24923

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0045786	negative regulation of cell cycle	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAP1A

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAP1A
10/24 Novoseek chemical compound relationships for RAP1A gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	70.31	49	12473665 (4), 2160589 (3), 10608844 (2), 1939245 (2) (see all 28)
gdp	66.65	16	10608844 (2), 2110451 (2), 11292831 (1), 1939245 (1) (see all 11)
guanosine	60.72	7	15613546 (1), 17954608 (1), 18362184 (1), 16043520 (1) (see all 6)
geranylgeranyl pyrophosphate	55.22	2	12427032 (1), 17640631 (1)
cyclic amp	53.96	42	16507992 (6), 15546918 (3), 15591041 (3), 14985123 (3) (see all 15)
forskolin	53.90	18	10908723 (4), 15345481 (1), 15601837 (1), 12464615 (1) (see all 12)
tyrosine	53.34	32	16170364 (2), 18789886 (2), 15982636 (2), 16182283 (2) (see all 21)
mevalonate	48.17	3	12427032 (2), 11788600 (1), 17640631 (1)
calcium	28.11	44	9789079 (4), 9029146 (4), 11278472 (3), 9731072 (2) (see all 24)
asparagine	23.51	3	15312909 (1), 17300802 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAP1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAP1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001010935

Sigma-Aldrich siRNA and siRNA Panels for RAP1A

Sigma-Aldrich shRNA for RAP1A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001010935 NM_002884

REFSEQ mRNAs for RAP1A gene (2 alternative transcripts):

NM_001010935.1 NM_002884.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001010935 NM_002884

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001010935
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001010935
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001010935

Additional cDNA sequence:

AB451235.1 AB451360.1 AF493912.1 AK293044.1 BC014086.2 BT019666.1 CR597469.1 CR623933.1

M22995.1 X12533.1

14 DOTS entries:

DT.70101779 DT.100800672 DT.451930 DT.121382734 DT.100800671 DT.99996642 DT.100800680 DT.95243672

DT.100028709 DT.102831457 DT.100800674 DT.100800676 DT.120749171 DT.75108365

24/389 AceView cDNA sequences (see all 389 ):

BQ722841 BX111098 CD108761 CA774853 CR597469 AF493912 BU184591 BQ694744

AA365910 AA628171 T53557 BQ638200 AA021557 BM752342 BQ009973 AA741314

CD517622 BG057240 CA414041 AA383199 X12533 BU167449 BF447109 BG231927

highest scoring ESTs for RAP1A:

M22995 AA100932 AA102393 AA193427 AA256183 AA279680 AA279804 AA361711 AA401232 AA436973

Unigene Cluster for RAP1A:

RAP1A, member of RAS oncogene family

Hs.190334 [show with all ESTs]

Unigene Representative Sequence: NM_001010935

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000369709 ENST00000356415

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RAP1A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAP1A

¹ / ² / ³

6 probe-sets matching RAP1A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38756_at²^{, 3}	U95-A	1	1.00	1.00	0.89	0.81	M22995	1.00	1.00	1.00	1
1848_at²^{, 3}	U95-A	1	1.00	1.00	0.87	1.19	M22995	1.00	1.00	1.00	1
202362_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002884	0.60	1.00	0.82	1
1555339_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202362_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555340_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATCCTCCCTA

SOURCE GeneReport for Unigene cluster: Hs.190334
Expression variation in blood from EXPOLDB for RAP1A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RAP1A gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RAP1A¹	--	RAP1A, member of RAS oncogene family	96.74(n) 100(a)	483225 XM_540344.2 XP_540344.2
chimpanzee (Pan troglodytes)	RAP1A¹	--	RAP1A, member of RAS oncogene family	100(n) 100(a)	469408 XM_524793.2 XP_524793.1
cow (Bos taurus)	RAP1A¹	--	RAP1A, member of RAS oncogene family	95.83(n) 100(a)	282031 NM_174448.2 NP_776873.1
mouse (Mus musculus)	Rap1a⁵ EG668838¹	3 (48.50 cM)⁵	RAS-related protein-1a⁵ predicted gene, EG668838¹	93.66(n)¹ 99.46(a)¹	668838¹ XM_001004974.1¹ XP_001004974.1¹ AA210264⁵ AI848598⁵ (see all 12)
zebrafish (Danio rerio)	wufc66g06²	--	Danio rerio, clone IMAGE5604882, mRNA	80.69(n)	BC049419.1

About this table Species with no ortholog for RAP1A

ENSEMBL Gene Tree for RAP1A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RAP1A gene

ENSG00000176276² RAP1B² ENSG00000214405²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/637 NCBI SNPs in RAP1A are shown (see all 637 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 189)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs6573^1,2	A,C,F,H,O	112056912(+)	`ATCCTC/ACCTAT`	2	--	ut3¹ ese³		6	MN EU EA WA	786
	rs1359414^1,2	A,C,F,H	111963158(-)	`AACCAT/CGAGAG`	2	--	ng5¹		11	NA EU EA WA	978
	rs4839155^1,2	A,C,F,H	111963012(+)	`GTCCGT/GGGCTG`	2	--	ng5¹		4	EU EA WA	398
--	rs2365321^1,2	C	111962540(-)	`tgaagC/Agttgg`	2	--	ng5¹		3	NA	140
	rs486982^1,2	A,C,F,H,O	112054637(+)	`ATTTGG/ATGCTT`	2	--	int¹		8	MN NA EU EA WA	716
	rs13059^1,2	A,C,F,H,O	111999349(-)	`TTCCCA/GTGGTC`	2	--	int¹		11	EU EA WA NA	978
	rs1324891^1,2	A,C,F,H,O	112040573(-)	`GACTAT/CAGTTT`	2	--	int¹		10	NS EU EA WA	630
	rs846261^1,2	A,C,F,H,O	112054920(+)	`TTTAGG/AAAAGA`	2	--	int¹		8	EU EA WA	838
	rs533900^1,2	A,C,F,H,O	111999442(+)	`TTGAGC/TGTGAT`	2	--	int¹		7	EU EA WA NA	556
	rs472159^1,2	A,C,F,H,O	111987860(+)	`GACAAC/TCCGTG`	2	--	int¹		16	EU EA WA NA	1414

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HapMap Linkage Disequilibrium images for RAP1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 179520

10/23 Novoseek disease relationships for RAP1A gene (see all 23 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tuberous sclerosis	52.12	2	7608212 (1), 12469204 (1)
thyroid papillary carcinoma	32.52	2	18948674 (1)
glanzmann thrombasthenia	27.74	1	10629034 (1)
granulomatous disease chronic	13.64	1	9731072 (1)
myeloid leukemia	13.59	2	15982636 (1), 18180377 (1)
tumors	11.45	35	12469204 (3), 8084835 (2), 8890957 (2), 2142634 (1) (see all 19)
myeloid leukemia chronic	3.97	1	16076873 (1)
azoospermia	2.31	1	15064832 (1)
myeloproliferative disorders	0.01	2	17383543 (1)
cancer lung	0.00	1	1485916 (1)

About this table

Human Genome Epidemiology Navigator: RAP1A (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/344 PubMed articles for RAP1A gene (see all 344 ):

The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. (PubMed id 1899909)^{1, 3, 4} Buss J.E.... Der C.J. (1991)
The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. (PubMed id 7791872)^{1, 3, 4} Nassar N....Wittinghofer A. (1995)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. (PubMed id 12444546)^{3, 4} Song C.... Kataoka T. (2002)
Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. (PubMed id 11022048)^{3, 4} Song C....Kataoka T. (2001)
Ras/Rap effector specificity determined by charge reversal. (PubMed id 8756332)^{3, 4} Nassar N....Wittinghofer A. (1996)
Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein. (PubMed id 2507536)^{3, 4} Nagata K....Nozawa Y. (1989)
Identification of a platelet Mr 22,000 GTP-binding protein as the novel smg-21 gene product having the same putative effector domain as the ras gene products. (PubMed id 3144274)^{3, 4} Ohmori T.... Takai Y. (1988)
Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. (PubMed id 3045729)^{3, 4} Pizon V.... Tavitian A. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5906	HGNC: 9855	AceView: RAP1A	Ensembl:ENSG00000116473	euGenes: HUgn5906
ECgene: RAP1A	H-InvDB: RAP1A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RAP1A	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RAP1A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RAP1A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAP1A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAP1A		Antibodies for RAP1A
	Explore super-pooled esiRNAs		Proteins for RAP1A
	Lentivirus-delivered shRNAs for RAP1A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RAP1A)
	Antibodies (RAP1A)
	Chimera RNAi (RAP1A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for RAP1A (Rap1)

	Recombinant Proteins (RAP1A + RAP1B)
	Antibodies (RAP1A + RAP1B)

Search OriGene for RAP1A

Search Tocris compounds for RAP1A

	Drugs for RAP1A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RAP1A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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RAP1A Gene at Home site.
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RAP1A Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for RAP1A

Summaries
for RAP1A

Genomic Location
for RAP1A

Proteins
for RAP1A

Protein Domains/
Families
for RAP1A

Gene Function
for RAP1A

Pathways & Interactions
for RAP1A

Drugs & Compounds
for RAP1A

Transcripts
for RAP1A

Expression
for RAP1A

Orthologs
for RAP1A

Paralogs
for RAP1A

SNPs/Variants
for RAP1A

Disorders & Mutations
for RAP1A

Medical News
for RAP1A

Publications
for RAP1A

Search for RAP1A

Genome Databases showing RAP1A

Other Databases showing RAP1A

Specialized Databases showing RAP1A

Licensable Technologies
for RAP1A

Services
for RAP1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAP1A Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor RAP1A

Summariesfor RAP1A

Genomic Locationfor RAP1A

Proteinsfor RAP1A

Protein Domains/Familiesfor RAP1A

Gene Functionfor RAP1A

Pathways & Interactionsfor RAP1A

Drugs & Compoundsfor RAP1A

Transcriptsfor RAP1A

Expression for RAP1A

Orthologsfor RAP1A

Paralogsfor RAP1A

SNPs/Variantsfor RAP1A

Disorders & Mutationsfor RAP1A

Medical Newsfor RAP1A

Publicationsfor RAP1A

Search for RAP1A

Genome Databases showing RAP1A

Other Databases showing RAP1A

Specialized Databases showing RAP1A

Licensable Technologiesfor RAP1A

Servicesfor RAP1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAP1A

Summaries
for RAP1A

Genomic Location
for RAP1A

Proteins
for RAP1A

Protein Domains/
Families
for RAP1A

Gene Function
for RAP1A

Pathways & Interactions
for RAP1A

Drugs & Compounds
for RAP1A

Transcripts
for RAP1A

Expression
for RAP1A

Orthologs
for RAP1A

Paralogs
for RAP1A

SNPs/Variants
for RAP1A

Disorders & Mutations
for RAP1A

Medical News
for RAP1A

Publications
for RAP1A

Licensable Technologies
for RAP1A

Services
for RAP1A