RANGRF Gene
protein-coding GIFtS: 47
GCID: GC17P008191
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RAN guanine nucleotide release factor
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Aliases
for RANGRF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAN Guanine Nucleotide Release Factor1 2 | | Ran-Binding Protein MOG12 3 | | MOG11 2 3 | | HSPC1651 | | RANGNRF1 2 3 | | MOG1 Homolog2 | | HSPC2361 2 | | RanGNRF3 |
Export aliases for RANGRF gene to outside databasesPrevious GC identifers: GC17P008133 GC17P008087 |
Summaries
for RANGRF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RANGRF:
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and toregulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results inmultiple transcript variants. (provided by RefSeq, Apr 2010)
UniProtKB/Swiss-Prot: MOG1_HUMAN, Q9HD47Function: May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surfacelocalization of SCN5A
|
Genomic Views
for RANGRF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RANGRF gene promoter:
Bach1 C/EBPbeta RP58 SREBP-1c MyoD SREBP-1b SREBP-1a FOXO4 Chx10 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RANGRF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RANGRF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13RANGRF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P008191: view genomic region
(about GC identifiers)
Start:
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8,191,815 bp from pter |
End:
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8,193,410 bp from pter |
Size:
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1,596 bases |
Orientation:
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plus strand |
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Proteins
for RANGRF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MOG1_HUMAN, Q9HD47 (See
protein sequence)Recommended Name: Ran guanine nucleotide release factor Size: 186 amino acids; 20448 Da
Subunit: Monomer (By similarity). Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 (Bysimilarity). Interacts with the cytoplasmic loop 2 of SCN5A
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm
Sequence caution: Sequence=AAF29129.1; Type=Frameshift; Positions=62, 93; Sequence=AAF87316.1; Type=Frameshift;Positions=62;
Secondary accessions: D3DTR6 Q68DI3 Q9BR68 Q9HD48 Q9NRU9 Q9P001 Q9P0P2Alternative splicing: 4 isoforms: Q9HD47-1 Q9HD47-2 Q9HD47-3 Q9HD47-4 Explore the universe of human proteins at neXtProt for RANGRF: NX_Q9HD47
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HD47
RANGRF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001171272.1 NP_001171273.1 NP_057576.2
ENSEMBL proteins: ENSP00000226105 ENSP00000383940 ENSP00000462310 ENSP00000413190
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RANGRF for ontologies About GeneDecksing
RANGRF Antibody Products:
Assay Products for RANGRF: |
Protein
Domains /
Families
for RANGRF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RANGRF for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HD47ProtoNet protein and cluster: Q9HD47 UniProtKB/Swiss-Prot: MOG1_HUMAN, Q9HD47Similarity: Belongs to the MOG1 family |
Function
for RANGRF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MOG1_HUMAN, Q9HD47Function: May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surfacelocalization of SCN5A
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RANGRF (see all 4)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANGRF |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RANGRF for ontologies About GeneDecksing
|
Pathways & Interactions
for RANGRF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RANGRF
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for RANGRF (Q9HD473 ENSP000002261054) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
RANGRF for ontologies About GeneDecksing
|
Drugs & Compounds
for RANGRF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RANGRF
1 HMDB Compound for RANGRF About this table
Search CenterWatch for drugs/clinical trials and news about RANGRF / MOG1
|
Transcripts
for RANGRF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RANGRF gene (3 alternative transcripts): NM_001177801.1 NM_001177802.1 NM_016492.4 Unigene Cluster for RANGRF: RAN guanine nucleotide release factor Hs.408233 [show with all ESTs]Unigene Representative Sequence: NM_0011778026 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000226105(uc002gkv.3 uc002gkw.3) ENST00000407006(uc002gkx.3)
ENST00000580434 ENST00000439238(uc002gky.3) ENST00000578849 ENST00000580777
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RANGRF (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RANGRF (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): RANGRF (NM_016492) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RANGRF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RANGRF |
Additional cDNA sequence: AF151070.1 AF168714.1 AF265205.1 AF265206.1 AK290399.1 BC006486.1 BC012552.1 BC100017.1 CR457206.1 CR749387.1 8 DOTS entries: DT.86852501 DT.100798239 DT.92430422 DT.100798241 DT.92430420 DT.102826452 DT.102826455 DT.95098113 24/181 AceView cDNA sequences (see all 181): AV708463 AW080519 BU730473 BF149175 AA586674 AI591409 AI336096 BC006486 AI886595 BF432661 AI189686 NM_016492 CK824889 AA243615 BM923902 CA308668 AF265205 CK824890 AW952583 BQ007550 BM264596 BU625036 BU687447 BQ181591
GeneLoc Exon Structure
|
Expression
for RANGRF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RANGRF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTTGCTGA
About this image
See RANGRF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RANGRF
SOURCE GeneReport for Unigene cluster: Hs.408233
UniProtKB/Swiss-Prot: MOG1_HUMAN, Q9HD47Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed
SABiosciences Custom PCR Arrays for RANGRF
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RANGRF
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RANGRF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RANGRF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RANGRF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANGRF |
Orthologs
for RANGRF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RANGRF gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for RANGRF (if available)
TreeFam Gene Tree for RANGRF (if available) |
Paralogs
for RANGRF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RANGRF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RANGRF (8191815 - 8193410 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RANGRF: --
Human Gene Mutation Database (HGMD): RANGRF
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RANGRF |
|
Disorders
/ Diseases
for RANGRF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RANGRF for disorders About GeneDecksing
OMIM gene information: 607954
OMIM disorders: --
2  diseases for RANGRF: About MalaCardsbrugada syndrome malaria
1 disease from the University of Copenhagen DISEASES database for RANGRF:Brugada syndrome Export disorders for RANGRF gene to outside databases
|
Publications
for RANGRF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RANGRF gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with RANGRF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of the human MOG1 gene. (PubMed id 11290418)1, 2, 3 Marfatia K.A.... Corbett A.H. (2001)
- Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5. (PubMed id 18184654)1, 2 Wu L....Wang Q.K. (2008)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- MOG1: a new susceptibility gene for Brugada syndrome. (PubMed id 21447824)1 Kattygnarath D....Guicheney P. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A novel nonsense variant in Nav1.5 cofactor MOG1 elim inates its sodium current increasing effect and may increase the risk of arrhyt hmias. (PubMed id 21621375)1 Olesen M.S....Svendsen J.H. (2011)
|
External Searches for RANGRF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RANGRF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RANGRF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RANGRF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RANGRF | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RANGRF gene:
Search GeneIP for patents involving RANGRF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RANGRF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | | | Recombinant Protein for RANGRF |
|
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 | | | RANGRF Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANGRF |
|  |  |  | | | | Search ThermoFisher Antibodies for RANGRF |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RANGRF |
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