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Aliases for RANGRF Gene

Aliases for RANGRF Gene

  • RAN Guanine Nucleotide Release Factor 2 3
  • Ran-Binding Protein MOG1 3 4
  • RANGNRF 3 4
  • MOG1 3 4
  • MOG1 Homolog (S. Cerevisiae) 2
  • MOG1 Homolog 3
  • HSPC165 3
  • HSPC236 3

External Ids for RANGRF Gene

Previous GeneCards Identifiers for RANGRF Gene

  • GC17P008133
  • GC17P008087
  • GC17P008191

Summaries for RANGRF Gene

Entrez Gene Summary for RANGRF Gene

  • This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

GeneCards Summary for RANGRF Gene

RANGRF (RAN Guanine Nucleotide Release Factor) is a Protein Coding gene. Diseases associated with RANGRF include brugada syndrome. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein transporter activity.

UniProtKB/Swiss-Prot for RANGRF Gene

  • May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANGRF Gene

Genomics for RANGRF Gene

Regulatory Elements for RANGRF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RANGRF Gene

8,288,427 bp from pter
8,290,092 bp from pter
1,666 bases
Plus strand

Genomic View for RANGRF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RANGRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANGRF Gene

Proteins for RANGRF Gene

  • Protein details for RANGRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ran guanine nucleotide release factor
    Protein Accession:
    Secondary Accessions:
    • D3DTR6
    • Q68DI3
    • Q9BR68
    • Q9HD48
    • Q9NRU9
    • Q9P001
    • Q9P0P2

    Protein attributes for RANGRF Gene

    186 amino acids
    Molecular mass:
    20448 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 (By similarity). Interacts with the cytoplasmic loop 2 of SCN5A.
    • Sequence=AAF29129.1; Type=Frameshift; Positions=62, 93; Evidence={ECO:0000305}; Sequence=AAF87316.1; Type=Frameshift; Positions=62; Evidence={ECO:0000305};

    Alternative splice isoforms for RANGRF Gene


neXtProt entry for RANGRF Gene

Proteomics data for RANGRF Gene at MOPED

Post-translational modifications for RANGRF Gene

  • Ubiquitination at Lys113 and Lys120
  • Modification sites at PhosphoSitePlus

Other Protein References for RANGRF Gene

No data available for DME Specific Peptides for RANGRF Gene

Domains for RANGRF Gene

Protein Domains for RANGRF Gene


Suggested Antigen Peptide Sequences for RANGRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9HD47
  • Belongs to the MOG1 family.
genes like me logo Genes that share domains with RANGRF: view

No data available for Gene Families for RANGRF Gene

Function for RANGRF Gene

Molecular function for RANGRF Gene

UniProtKB/Swiss-Prot Function: May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.

Gene Ontology (GO) - Molecular Function for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity ISS --
GO:0005087 Ran guanyl-nucleotide exchange factor activity ISS --
GO:0008536 Ran GTPase binding ISS --
GO:0008565 protein transporter activity IMP 23420830
GO:0017080 sodium channel regulator activity IMP 23420830
genes like me logo Genes that share ontologies with RANGRF: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RANGRF Gene

Localization for RANGRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANGRF Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm.

Subcellular locations from

Jensen Localization Image for RANGRF Gene COMPARTMENTS Subcellular localization image for RANGRF gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11290418
GO:0005654 nucleoplasm ISS --
GO:0005737 cytoplasm IDA --
GO:0005791 rough endoplasmic reticulum IDA 23420830
GO:0005886 plasma membrane IC 18184654
genes like me logo Genes that share ontologies with RANGRF: view

Pathways for RANGRF Gene

SuperPathways for RANGRF Gene

No Data Available

Gene Ontology (GO) - Biological Process for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002027 regulation of heart rate TAS 21621375
GO:0003254 regulation of membrane depolarization IMP 23420830
GO:0006888 ER to Golgi vesicle-mediated transport IMP 23420830
GO:0032527 protein exit from endoplasmic reticulum IMP 23420830
GO:0042391 regulation of membrane potential IDA 18184654
genes like me logo Genes that share ontologies with RANGRF: view

No data available for Pathways by source for RANGRF Gene

Compounds for RANGRF Gene

(1) HMDB Compounds for RANGRF Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with RANGRF: view

Transcripts for RANGRF Gene

Unigene Clusters for RANGRF Gene

RAN guanine nucleotide release factor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RANGRF

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANGRF Gene

No ASD Table

Relevant External Links for RANGRF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RANGRF Gene

mRNA expression in normal human tissues for RANGRF Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANGRF Gene

SOURCE GeneReport for Unigene cluster for RANGRF Gene Hs.408233

mRNA Expression by UniProt/SwissProt for RANGRF Gene

Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed.
genes like me logo Genes that share expressions with RANGRF: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RANGRF Gene

Orthologs for RANGRF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANGRF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RANGRF 35
  • 98.92 (n)
  • 99.46 (a)
  • 99 (a)
(Bos Taurus)
Mammalia RANGRF 35
  • 88.89 (n)
  • 88.71 (a)
  • 90 (a)
(Canis familiaris)
Mammalia RANGRF 35
  • 86.74 (n)
  • 85.48 (a)
  • 82 (a)
(Mus musculus)
Mammalia Gm10355 36
  • 86 (a)
Rangrf 35
  • 86.49 (n)
  • 88.65 (a)
Rangrf 16
Rangrf 36
  • 89 (a)
(Monodelphis domestica)
Mammalia RANGRF 36
  • 46 (a)
(Rattus norvegicus)
Mammalia Rangrf 35
  • 86.13 (n)
  • 88.65 (a)
(Anolis carolinensis)
Reptilia RANGRF 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rangrf 35
  • 55.87 (n)
  • 55.11 (a)
(Danio rerio)
Actinopterygii rangrf 35
  • 52.27 (n)
  • 47.73 (a)
rangrf 36
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOG1 36
  • 22 (a)
MOG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69680 35
  • 46.14 (n)
  • 33.9 (a)
(Oryza sativa)
Liliopsida Os04g0459600 35
  • 47.16 (n)
  • 34.09 (a)
Species with no ortholog for RANGRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RANGRF Gene

Gene Tree for RANGRF (if available)
Gene Tree for RANGRF (if available)

Paralogs for RANGRF Gene

No data available for Paralogs for RANGRF Gene

Variants for RANGRF Gene

Sequence variations from dbSNP and Humsavar for RANGRF Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6503097 -- 8,286,935(+) AGCTA(C/T)GACTG upstream-variant-2KB
rs8077178 -- 8,286,611(+) TTTTT(C/G)CTCCT upstream-variant-2KB
rs9916737 -- 8,286,990(+) aaaaa(A/C)aaaca upstream-variant-2KB
rs56970209 -- 8,286,924(+) AGGCT(G/T)CAGTG upstream-variant-2KB
rs78241146 -- 8,286,511(+) CTGAC(C/T)GTGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RANGRF Gene

Variant ID Type Subtype PubMed ID
nsv833353 CNV Loss 17160897
nsv907661 CNV Gain 21882294

Relevant External Links for RANGRF Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANGRF Gene

Disorders for RANGRF Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RANGRF Gene including...

Search for RANGRF Gene in MalaCards »

(1) University of Copenhagen DISEASES for RANGRF Gene

genes like me logo Genes that share disorders with RANGRF: view

No data available for UniProtKB/Swiss-Prot for RANGRF Gene

Publications for RANGRF Gene

  1. Identification and characterization of the human MOG1 gene. (PMID: 11290418) Marfatia K.A. … Corbett A.H. (Gene 2001) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5. (PMID: 18184654) Wu L. … Wang Q.K. (J. Biol. Chem. 2008) 3 4
  4. Brugada Syndrome (PMID: 20301690) Pagon R.A. … Stephens K. ( 1993) 3
  5. MOG1: a new susceptibility gene for Brugada syndrome. (PMID: 21447824) Kattygnarath D. … Guicheney P. (Circ Cardiovasc Genet 2011) 3

Products for RANGRF Gene

Sources for RANGRF Gene

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