Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RANGRF Gene

protein-coding   GIFtS: 49
GCID: GC17P008191

RAN Guanine Nucleotide Release Factor

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RAN Guanine Nucleotide Release Factor1 2     MOG1 Homolog (S. Cerevisiae)1
Ran-Binding Protein MOG12 3     HSPC2362
MOG12 3     MOG1 Homolog2
RANGNRF2 3     RanGNRF3

External Ids:    HGNC: 176791   Entrez Gene: 290982   Ensembl: ENSG000001089617   OMIM: 6079545   UniProtKB: Q9HD473   

Export aliases for RANGRF gene to outside databases

Previous GC identifers: GC17P008133 GC17P008087


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RANGRF Gene:
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to
regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Apr 2010)

GeneCards Summary for RANGRF Gene:
RANGRF (RAN guanine nucleotide release factor) is a protein-coding gene. Diseases associated with RANGRF include brugada syndrome. GO annotations related to this gene include protein transporter activity and guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot: MOG1_HUMAN, Q9HD47
Function: May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface
localization of SCN5A




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RANGRF gene promoter:
         Bach1   C/EBPbeta   RP58   SREBP-1c   MyoD   SREBP-1b   SREBP-1a   FOXO4   Chx10   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRANGRF promoter sequence
   Search Chromatin IP Primers for RANGRF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RANGRF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13

RANGRF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RANGRF gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P008191:  view genomic region     (about GC identifiers)

Start:
8,191,815 bp from pter      End:
8,193,410 bp from pter
Size:
1,596 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MOG1_HUMAN, Q9HD47 (See protein sequence)
Recommended Name: Ran guanine nucleotide release factor  
Size: 186 amino acids; 20448 Da
Subunit: Monomer (By similarity). Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1
(By similarity). Interacts with the cytoplasmic loop 2 of SCN5A
Sequence caution: Sequence=AAF29129.1; Type=Frameshift; Positions=62, 93; Sequence=AAF87316.1; Type=Frameshift;
Positions=62;
Secondary accessions: D3DTR6 Q68DI3 Q9BR68 Q9HD48 Q9NRU9 Q9P001 Q9P0P2
Alternative splicing: 4 isoforms:  Q9HD47-1   Q9HD47-2   Q9HD47-3   Q9HD47-4   

Explore the universe of human proteins at neXtProt for RANGRF: NX_Q9HD47

Explore proteomics data for RANGRF at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys113, Lys120
  • Modification sites at PhosphoSitePlus

  • See RANGRF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171272.1  NP_001171273.1  NP_057576.2  

    ENSEMBL proteins: 
     ENSP00000226105   ENSP00000383940   ENSP00000462310   ENSP00000413190  

    RANGRF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RANGRF
    OriGene Protein Over-expression Lysate for RANGRF
    OriGene MassSpec for RANGRF
    OriGene Custom Protein Services for RANGRF
    GenScript Custom Purified and Recombinant Proteins Services for RANGRF
    Novus Biologicals RANGRF Proteins
    Novus Biologicals RANGRF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RANGRF
    Cloud-Clone Corp. Proteins for RANGRF

    RANGRF Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RANGRF
    Novus Biologicals RANGRF Antibodies
    Abcam antibodies for RANGRF
    Cloud-Clone Corp. Antibodies for RANGRF
    Search ThermoFisher Antibodies for RANGRF
    LSBio Antibodies in human, mouse, rat for RANGRF

    RANGRF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RANGRF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RANGRF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RANGRF
    Cloud-Clone Corp. CLIAs for RANGRF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR016123 Mog1/PsbP_a/b/a-sand
     IPR007681 Mog1

    Graphical View of Domain Structure for InterPro Entry Q9HD47

    ProtoNet protein and cluster: Q9HD47

    UniProtKB/Swiss-Prot: MOG1_HUMAN, Q9HD47
    Similarity: Belongs to the MOG1 family


    RANGRF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOG1_HUMAN, Q9HD47
    Function: May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface
    localization of SCN5A

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ISS--
    GO:0008536Ran GTPase binding ISS--
    GO:0008565protein transporter activity IMP--
    GO:0017080sodium channel regulator activity IMP--
    GO:0044325ion channel binding IPI18184654
         
    RANGRF for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RANGRF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RANGRF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RANGRF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RANGRF

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RANGRF using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RANGRF:
    hsa-miR-142-5p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidRANGRF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RANGRF
    Predesigned siRNA for gene silencing in human, mouse, rat RANGRF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RANGRF

    Clone
    Products:
         
    OriGene clones in human, mouse for RANGRF (see all 16)
    OriGene ORF clones in mouse, rat for RANGRF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RANGRF (NM_016492)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RANGRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RANGRF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RANGRF
    Browse ESI BIO Cell Lines and PureStem Progenitors for RANGRF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANGRF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MOG1_HUMAN, Q9HD47: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005791rough endoplasmic reticulum IDA--

    RANGRF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RANGRF
    Interactions:

        GeneGlobe Interaction Network for RANGRF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RANGRF (Q9HD473 ENSP000002261054) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANP628263, ENSP000003961274I2D: score=2 STRING: ENSP00000396127
    RANBP1P434873, ENSP000003275834I2D: score=1 STRING: ENSP00000327583
    NUTF2ENSP000002191694STRING: ENSP00000219169
    RCC1ENSP000003629374STRING: ENSP00000362937
    NUP153ENSP000002620774STRING: ENSP00000262077
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002027regulation of heart rate TAS--
    GO:0003254regulation of membrane depolarization IMP--
    GO:0006888ER to Golgi vesicle-mediated transport IMP--
    GO:0032527protein exit from endoplasmic reticulum IMP--
    GO:0042391regulation of membrane potential IDA18184654

    RANGRF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RANGRF (MOG1)

    1 HMDB Compound for RANGRF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RANGRF gene (3 alternative transcripts): 
    NM_001177801.1  NM_001177802.1  NM_016492.4  

    Unigene Cluster for RANGRF:

    RAN guanine nucleotide release factor
    Hs.408233  [show with all ESTs]
    Unigene Representative Sequence: NM_001177802
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226105(uc002gkv.3 uc002gkw.3) ENST00000407006(uc002gkx.3)
    ENST00000580434 ENST00000439238(uc002gky.3) ENST00000578849 ENST00000580777

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RANGRF using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RANGRF:
    hsa-miR-142-5p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidRANGRF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RANGRF
    Predesigned siRNA for gene silencing in human, mouse, rat RANGRF
    Clone
    Products:
         
    OriGene clones in human, mouse for RANGRF (see all 16)
    OriGene ORF clones in mouse, rat for RANGRF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RANGRF (NM_016492)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RANGRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RANGRF
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RANGRF
    OriGene qSTAR qPCR primer pairs in human, mouse for RANGRF
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RANGRF
      QuantiTect SYBR Green Assays in human, mouse, rat RANGRF
      QuantiFast Probe-based Assays in human, mouse, rat RANGRF

    Additional mRNA sequence: 

    AF151070.1 AF168714.1 AF265205.1 AF265206.1 AK290399.1 BC006486.1 BC012552.1 BC100017.1 
    CR457206.1 CR749387.1 

    8 DOTS entries:

    DT.86852501  DT.100798239  DT.92430422  DT.100798241  DT.92430420  DT.102826452  DT.102826455  DT.95098113 

    Selected AceView cDNA sequences (see all 181):

    BQ007550 NM_016492 AA243615 BU687447 AI359585 AI306687 BX102136 AI189686 
    AI381210 AI591409 BM923902 AI582792 BU625036 AV759821 CK824890 CK824889 
    AF265205 AA748322 AA768375 AI336096 CB217686 BM264596 AA586674 BC006486 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RANGRF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTTGCTGA
    RANGRF Expression
    About this image

    RANGRF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RANGRF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408233

    UniProtKB/Swiss-Prot: MOG1_HUMAN, Q9HD47
    Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed

        Custom PCR Arrays for RANGRF
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RANGRF
    OriGene qSTAR qPCR primer pairs in human, mouse for RANGRF
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RANGRF
    QuantiTect SYBR Green Assays in human, mouse, rat RANGRF
    QuantiFast Probe-based Assays in human, mouse, rat RANGRF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANGRF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RANGRF gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rangrf1 , 5 RAN guanine nucleotide release factor1, 5 86.49(n)1
    88.65(a)1
      11 (42.24 cM)5
    577851  NM_021329.31  NP_067304.11 
     689724845 
    lizard
    (Anolis carolinensis)
    Reptilia RANGRF6
    RAN guanine nucleotide release factor
    47(a)
    1 ↔ 1
    GL343466.1(168780-181409)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rangrf1 RAN guanine nucleotide release factor 55.87(n)
    55.11(a)
      496602  XM_004919402.1  XP_004919459.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rangrf1 RAN guanine nucleotide release factor 52.27(n)
    47.73(a)
      559102  NM_001099995.1  NP_001093465.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MOG1(YJR074W)4 Conserved nuclear protein that interacts with GTP-Gsp1p, more   --   10(573095-573751) 853537  NP_012608.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G696801 AT1G69680 46.14(n)
    33.9(a)
      843304  NM_105636.2  NP_564972.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g04596001 Os04g0459600 47.16(n)
    34.09(a)
      4336045  NM_001059520.1  NP_001052985.1 


    ENSEMBL Gene Tree for RANGRF (if available)
    TreeFam Gene Tree for RANGRF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RANGRF (see all 103)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809652961,2
    --8178922(+) AAGTCC/TGAGAC 3 -- us2k10--------
    rs1850717621,2
    C--8178923(+) AGTCCA/GAGACC 3 -- us2k10--------
    rs1905522041,2
    --8178985(+) ACACAA/CAAATT 3 -- us2k10--------
    rs1499071451,2
    --8179064(+) GCCCAC/TAAGGT 3 -- us2k10--------
    rs569702091,2
    C,F--8179077(+) AGGCTG/TCAGTG 3 -- us2k13Minor allele frequency- T:0.05CSA WA NA 240
    rs65030971,2
    C,F,A,H--8179088(+) AGCTAT/CGACTG 3 -- us2k112Minor allele frequency- C:0.41NA WA CSA EA 377
    rs1171505951,2
    F--8179129(+) AGACCG/ACCTCT 3 -- us2k11Minor allele frequency- A:0.03EA 120
    rs99167371,2
    C--8179143(+) aaaaaA/Caaaca 3 -- us2k1 trp31Minor allele frequency- C:0.00NA 2
    rs1449231301,2
    C--8179155(+) AAAAAG/TACTCA 3 -- us2k10--------
    rs1137616491,2
    C,F--8179251(+) GGCAAG/AGTAAG 3 -- us2k11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for RANGRF (8191815 - 8193410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RANGRF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833353CNV Loss17160897
    nsv907661CNV Gain21882294

    Human Gene Mutation Database (HGMD): RANGRF
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RANGRF
    DNA2.0 Custom Variant and Variant Library Synthesis for RANGRF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607954    OMIM disorders: --

    1 disease for RANGRF:    About MalaCards
    brugada syndrome

    1 disease from the University of Copenhagen DISEASES database for RANGRF:
    Brugada syndrome

    RANGRF for disorders           About GeneDecksing


    Export disorders for RANGRF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RANGRF gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with RANGRF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of the human MOG1 gene. (PubMed id 11290418)1, 2, 3 Marfatia K.A.... Corbett A.H. (Gene 2001)
    2. Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5. (PubMed id 18184654)1, 2 Wu L....Wang Q.K. (J. Biol. Chem. 2008)
    3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. MOG1: a new susceptibility gene for Brugada syndrome. (PubMed id 21447824)1 Kattygnarath D....Guicheney P. (Circ Cardiovasc Genet 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias. (PubMed id 21621375)1 Olesen M.S....Svendsen J.H. (Can J Cardiol 2011)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29098 HGNC: 17679 AceView: RANGNRF Ensembl:ENSG00000108961 euGenes: HUgn29098
    ECgene: RANGRF H-InvDB: RANGRF

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RANGRF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RANGRF gene:
    Search GeneIP for patents involving RANGRF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RANGRF  
     OriGene qPCR primer pairs and template standards for RANGRF   OriGene Protein Over-expression Lysate for RANGRF  
     OriGene MassSpec something-or-other for RANGRF   OriGene clones in human, mouse for RANGRF  
     OriGene qSTAR qPCR primer pairs in human, mouse for RANGRF   OriGene Purified Protein for RANGRF  
     OriGene ORF clones in mouse, rat for RANGRF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RANGRF   OriGene Custom Protein Services for RANGRF  

     
     
     Block miRNA regulation of human, mouse, rat RANGRF using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RANGRF
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RANGRF Predesigned siRNA for gene silencing in human, mouse, rat RANGRF
     QuantiFast Probe-based Assays in human, mouse, rat RANGRF QuantiTect SYBR Green Assays in human, mouse, rat RANGRF
     Custom PCR Arrays for RANGRF Search Chromatin IP Primers for RANGRF
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RANGRF  GeneGlobe Interaction Network for RANGRF
     Regulatory tfbs in RANGRF promoter
     GenScript Custom Purified and Recombinant Proteins Services for RANGRF GenScript cDNA clones with any tag delivered in your preferred vector for RANGRF
     GenScript Custom Assay Services for RANGRF GenScript Custom overexpressing Cell Line Services for RANGRF
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RANGRF (MOG1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RANGRF antibodies
     RANGRF proteins
     RANGRF lysates
     Antibodies for RANGRF
     See all of Abcam's Antibodies, Kits and Proteins for RANGRF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RANGRF
     Proteins for RANGRF
     Antibodies for RANGRF
     ELISAs for RANGRF
     CLIAs for RANGRF



     Browse ESI BIO Cell Lines and PureStem Progenitors for RANGRF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANGRF
     SwitchGear 3'UTR luciferase reporter plasmids for RANGRF
     SwitchGear Promoter luciferase reporter plasmids for RANGRF
     Search ThermoFisher Antibodies for RANGRF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RANGRF
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RANGRF
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RANGRF
     LSBio Antibodies in human, mouse, rat for RANGRF
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RANGRF gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4