Aliases for RANGRF Gene
External Ids for RANGRF Gene
Previous GeneCards Identifiers for RANGRF Gene
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
GeneCards Summary for RANGRF Gene
RANGRF (RAN Guanine Nucleotide Release Factor) is a Protein Coding gene. Diseases associated with RANGRF include brugada syndrome 9 and congenital heart block. Among its related pathways are Cardiac conduction and Phase 1 - inactivation of fast Na+ channels. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein transporter activity.
UniProtKB/Swiss-Prot for RANGRF Gene
May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.