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Aliases for RANGRF Gene

Aliases for RANGRF Gene

  • RAN Guanine Nucleotide Release Factor 2 3 5
  • Ran-Binding Protein MOG1 3 4
  • RANGNRF 3 4
  • MOG1 3 4
  • MOG1 Homolog (S. Cerevisiae) 2
  • MOG1 Homolog 3
  • HSPC165 3
  • HSPC236 3

External Ids for RANGRF Gene

Previous GeneCards Identifiers for RANGRF Gene

  • GC17P008133
  • GC17P008087
  • GC17P008191

Summaries for RANGRF Gene

Entrez Gene Summary for RANGRF Gene

  • This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

GeneCards Summary for RANGRF Gene

RANGRF (RAN Guanine Nucleotide Release Factor) is a Protein Coding gene. Diseases associated with RANGRF include Brugada Syndrome, Rangrf-Related and Sick Sinus Syndrome. Among its related pathways are Cardiac conduction and Phase 0 - rapid depolarisation. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein transporter activity.

UniProtKB/Swiss-Prot for RANGRF Gene

  • May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANGRF Gene

Genomics for RANGRF Gene

Regulatory Elements for RANGRF Gene

Enhancers for RANGRF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G008245 1.4 ENCODE dbSUPER 13.2 -40.5 -40457 5.5 CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF416 ZNF263 SP3 NFYC SSRP1 PFAS ENSG00000265749 SENP3 SNORD10 SLC25A35 SNORA48 CTC1 NLGN2 CNTROB KCTD11
GH17G008137 1.7 Ensembl ENCODE dbSUPER 10.3 -148.9 -148937 3.7 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 NFYC DVL2 PFAS ENSG00000265749 CTC1 SNORD10 CNTROB SENP3 SNORA48 KCTD11 NEURL4
GH17G008478 1.6 Ensembl ENCODE dbSUPER 10.2 +191.9 191861 2.5 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 RNU7-43P MYH10 ENSG00000212206 RNF222 ODF4 RANGRF SPDYE4 NDEL1 PIR54625 GC17P008478
GH17G008409 1.2 Ensembl ENCODE 10.6 +122.1 122121 1.2 ARID4B ZNF48 GLIS2 ZNF143 FOS ZNF263 MXD4 MIER2 REST PPARG RPL26 KRBA2 SLC25A35 RANGRF PFAS NDEL1 RNF222
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RANGRF on UCSC Golden Path with GeneCards custom track

Promoters for RANGRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090983 413 1201 FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for RANGRF Gene

8,288,387 bp from pter
8,290,092 bp from pter
1,706 bases
Plus strand

Genomic View for RANGRF Gene

Genes around RANGRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANGRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANGRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANGRF Gene

Proteins for RANGRF Gene

  • Protein details for RANGRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ran guanine nucleotide release factor
    Protein Accession:
    Secondary Accessions:
    • D3DTR6
    • Q68DI3
    • Q9BR68
    • Q9HD48
    • Q9NRU9
    • Q9P001
    • Q9P0P2

    Protein attributes for RANGRF Gene

    186 amino acids
    Molecular mass:
    20448 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 (By similarity). Interacts with the cytoplasmic loop 2 of SCN5A.
    • Sequence=AAF29129.1; Type=Frameshift; Positions=62, 93; Evidence={ECO:0000305}; Sequence=AAF87316.1; Type=Frameshift; Positions=62; Evidence={ECO:0000305};

    Alternative splice isoforms for RANGRF Gene


neXtProt entry for RANGRF Gene

Post-translational modifications for RANGRF Gene

  • Ubiquitination at isoforms=2120
  • Modification sites at PhosphoSitePlus

Other Protein References for RANGRF Gene

No data available for DME Specific Peptides for RANGRF Gene

Domains & Families for RANGRF Gene

Protein Domains for RANGRF Gene


Suggested Antigen Peptide Sequences for RANGRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MOG1 family.
  • Belongs to the MOG1 family.
genes like me logo Genes that share domains with RANGRF: view

No data available for Gene Families for RANGRF Gene

Function for RANGRF Gene

Molecular function for RANGRF Gene

UniProtKB/Swiss-Prot Function:
May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.

Gene Ontology (GO) - Molecular Function for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity ISS,IEA --
GO:0005087 Ran guanyl-nucleotide exchange factor activity ISS --
GO:0008536 Ran GTPase binding ISS --
GO:0008565 protein transporter activity IMP 23420830
GO:0017080 sodium channel regulator activity IMP 23420830
genes like me logo Genes that share ontologies with RANGRF: view

Phenotypes for RANGRF Gene

GenomeRNAi human phenotypes for RANGRF:
genes like me logo Genes that share phenotypes with RANGRF: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RANGRF Gene

Localization for RANGRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANGRF Gene

Nucleus. Cytoplasm. Note=May shuttle between the nucleus and cytoplasm. {ECO:0000269 PubMed:11290418}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANGRF gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
endoplasmic reticulum 4
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11290418
GO:0005654 nucleoplasm ISS,IDA --
GO:0005737 cytoplasm IDA 11290418
GO:0005791 rough endoplasmic reticulum IDA 23420830
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RANGRF: view

Pathways & Interactions for RANGRF Gene

genes like me logo Genes that share pathways with RANGRF: view

Pathways by source for RANGRF Gene

Gene Ontology (GO) - Biological Process for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002027 regulation of heart rate TAS 21621375
GO:0003254 regulation of membrane depolarization IMP 23420830
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IMP 23420830
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RANGRF: view

No data available for SIGNOR curated interactions for RANGRF Gene

Drugs & Compounds for RANGRF Gene

(1) Drugs for RANGRF Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RANGRF: view

Transcripts for RANGRF Gene

Unigene Clusters for RANGRF Gene

RAN guanine nucleotide release factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANGRF Gene

No ASD Table

Relevant External Links for RANGRF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RANGRF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RANGRF Gene

Protein differential expression in normal tissues from HIPED for RANGRF Gene

This gene is overexpressed in Ovary (15.6), Heart (9.5), and Lymph node (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANGRF Gene

NURSA nuclear receptor signaling pathways regulating expression of RANGRF Gene:


SOURCE GeneReport for Unigene cluster for RANGRF Gene:


mRNA Expression by UniProt/SwissProt for RANGRF Gene:

Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed.

Evidence on tissue expression from TISSUES for RANGRF Gene

  • Blood(4.2)
  • Bone marrow(4.2)
  • Lung(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with RANGRF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANGRF Gene

Orthologs for RANGRF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANGRF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RANGRF 34 35
  • 98.92 (n)
(Bos Taurus)
Mammalia RANGRF 34 35
  • 88.89 (n)
(Canis familiaris)
Mammalia RANGRF 34 35
  • 86.74 (n)
(Mus musculus)
Mammalia Rangrf 34 16 35
  • 86.49 (n)
Gm10355 35
  • 86 (a)
(Rattus norvegicus)
Mammalia Rangrf 34
  • 86.13 (n)
(Monodelphis domestica)
Mammalia RANGRF 35
  • 46 (a)
(Anolis carolinensis)
Reptilia RANGRF 35
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rangrf 34
  • 55.87 (n)
(Danio rerio)
Actinopterygii rangrf 34 35
  • 52.27 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOG1 35 37
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69680 34
  • 46.14 (n)
(Oryza sativa)
Liliopsida Os04g0459600 34
  • 47.16 (n)
Species where no ortholog for RANGRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RANGRF Gene

Gene Tree for RANGRF (if available)
Gene Tree for RANGRF (if available)

Paralogs for RANGRF Gene

No data available for Paralogs for RANGRF Gene

Variants for RANGRF Gene

Sequence variations from dbSNP and Humsavar for RANGRF Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs140704891 Likely benign 8,289,059(+) GGGGC(G/T)AAGCG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, utr-variant-3-prime, stop-gained
rs150856064 Likely benign 8,288,840(+) CCATC(A/C/T)TCCCC intron-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs151189313 Uncertain significance 8,289,515(+) AGGAC(A/G/T)TGACA intron-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs751751942 Uncertain significance 8,289,312(+) GTGGA(C/G)TCTGT intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs762109580 Uncertain significance 8,289,010(+) ACGGA(A/C)CAGAG intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RANGRF Gene

Variant ID Type Subtype PubMed ID
nsv833353 CNV loss 17160897

Variation tolerance for RANGRF Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RANGRF Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANGRF Gene

Disorders for RANGRF Gene

MalaCards: The human disease database

(3) MalaCards diseases for RANGRF Gene - From: GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
brugada syndrome, rangrf-related
sick sinus syndrome
  • sinus node infection
brugada syndrome
  • bangungut
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RANGRF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RANGRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RANGRF Gene

Publications for RANGRF Gene

  1. Identification and characterization of the human MOG1 gene. (PMID: 11290418) Marfatia K.A. … Corbett A.H. (Gene 2001) 2 3 4 64
  2. Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5. (PMID: 18184654) Wu L. … Wang Q.K. (J. Biol. Chem. 2008) 3 4 64
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  4. The perfect storm? Histiocytoid cardiomyopathy and compound CACNA2D1 and RANGRF mutation in a baby. (PMID: 24438356) Cataldo S. … Marziliano N. (Cardiol Young 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for RANGRF Gene

Sources for RANGRF Gene

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