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Aliases for RANGRF Gene

Aliases for RANGRF Gene

  • RAN Guanine Nucleotide Release Factor 2 3 5
  • Ran-Binding Protein MOG1 3 4
  • RANGNRF 3 4
  • MOG1 3 4
  • MOG1 Homolog (S. Cerevisiae) 2
  • MOG1 Homolog 3
  • HSPC165 3
  • HSPC236 3

External Ids for RANGRF Gene

Previous GeneCards Identifiers for RANGRF Gene

  • GC17P008133
  • GC17P008087
  • GC17P008191

Summaries for RANGRF Gene

Entrez Gene Summary for RANGRF Gene

  • This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

GeneCards Summary for RANGRF Gene

RANGRF (RAN Guanine Nucleotide Release Factor) is a Protein Coding gene. Diseases associated with RANGRF include brugada syndrome 9 and congenital heart block. Among its related pathways are Cardiac conduction and Phase 1 - inactivation of fast Na+ channels. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and protein transporter activity.

UniProtKB/Swiss-Prot for RANGRF Gene

  • May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANGRF Gene

Genomics for RANGRF Gene

Regulatory Elements for RANGRF Gene

Promoters for RANGRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RANGRF on UCSC Golden Path with GeneCards custom track

Genomic Location for RANGRF Gene

Chromosome:
17
Start:
8,288,387 bp from pter
End:
8,290,092 bp from pter
Size:
1,706 bases
Orientation:
Plus strand

Genomic View for RANGRF Gene

Genes around RANGRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANGRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANGRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANGRF Gene

Proteins for RANGRF Gene

  • Protein details for RANGRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD47-MOG1_HUMAN
    Recommended name:
    Ran guanine nucleotide release factor
    Protein Accession:
    Q9HD47
    Secondary Accessions:
    • D3DTR6
    • Q68DI3
    • Q9BR68
    • Q9HD48
    • Q9NRU9
    • Q9P001
    • Q9P0P2

    Protein attributes for RANGRF Gene

    Size:
    186 amino acids
    Molecular mass:
    20448 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 (By similarity). Interacts with the cytoplasmic loop 2 of SCN5A.
    SequenceCaution:
    • Sequence=AAF29129.1; Type=Frameshift; Positions=62, 93; Evidence={ECO:0000305}; Sequence=AAF87316.1; Type=Frameshift; Positions=62; Evidence={ECO:0000305};

    Alternative splice isoforms for RANGRF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANGRF Gene

Proteomics data for RANGRF Gene at MOPED

Post-translational modifications for RANGRF Gene

  • Ubiquitination at Lys 120
  • Modification sites at PhosphoSitePlus

Other Protein References for RANGRF Gene

No data available for DME Specific Peptides for RANGRF Gene

Domains & Families for RANGRF Gene

Protein Domains for RANGRF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RANGRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HD47

UniProtKB/Swiss-Prot:

MOG1_HUMAN :
  • Belongs to the MOG1 family.
Family:
  • Belongs to the MOG1 family.
genes like me logo Genes that share domains with RANGRF: view

No data available for Gene Families for RANGRF Gene

Function for RANGRF Gene

Molecular function for RANGRF Gene

UniProtKB/Swiss-Prot Function:
May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.

Gene Ontology (GO) - Molecular Function for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008536 Ran GTPase binding ISS --
genes like me logo Genes that share ontologies with RANGRF: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RANGRF Gene

Localization for RANGRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANGRF Gene

Nucleus. Cytoplasm. Note=May shuttle between the nucleus and cytoplasm. {ECO:0000269 PubMed:11290418}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RANGRF Gene COMPARTMENTS Subcellular localization image for RANGRF gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
plasma membrane 4
cytosol 3
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11290418
GO:0005791 rough endoplasmic reticulum IDA 23420830
GO:0014704 intercalated disc ISS 18184654
genes like me logo Genes that share ontologies with RANGRF: view

Pathways & Interactions for RANGRF Gene

genes like me logo Genes that share pathways with RANGRF: view

Pathways by source for RANGRF Gene

Gene Ontology (GO) - Biological Process for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003254 regulation of membrane depolarization IMP 23420830
GO:0032527 protein exit from endoplasmic reticulum IMP 23420830
GO:0043547 positive regulation of GTPase activity ISS --
GO:0090004 positive regulation of establishment of protein localization to plasma membrane IMP 23420830
GO:1902305 regulation of sodium ion transmembrane transport IMP 23420830
genes like me logo Genes that share ontologies with RANGRF: view

No data available for SIGNOR curated interactions for RANGRF Gene

Drugs & Compounds for RANGRF Gene

(1) Drugs for RANGRF Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RANGRF: view

Transcripts for RANGRF Gene

Unigene Clusters for RANGRF Gene

RAN guanine nucleotide release factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RANGRF Gene

No ASD Table

Relevant External Links for RANGRF Gene

GeneLoc Exon Structure for
RANGRF
ECgene alternative splicing isoforms for
RANGRF

Expression for RANGRF Gene

mRNA expression in normal human tissues for RANGRF Gene

Protein differential expression in normal tissues from HIPED for RANGRF Gene

This gene is overexpressed in Ovary (15.6), Heart (9.5), and Lymph node (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANGRF Gene



SOURCE GeneReport for Unigene cluster for RANGRF Gene Hs.408233

mRNA Expression by UniProt/SwissProt for RANGRF Gene

Q9HD47-MOG1_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed.
genes like me logo Genes that share expression patterns with RANGRF: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for RANGRF Gene

Orthologs for RANGRF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANGRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANGRF 36
  • 99 (a)
OneToOne
RANGRF 35
  • 98.92 (n)
  • 99.46 (a)
cow
(Bos Taurus)
Mammalia RANGRF 36
  • 90 (a)
OneToOne
RANGRF 35
  • 88.89 (n)
  • 88.71 (a)
dog
(Canis familiaris)
Mammalia RANGRF 35
  • 86.74 (n)
  • 85.48 (a)
RANGRF 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rangrf 16
Rangrf 35
  • 86.49 (n)
  • 88.65 (a)
Gm10355 36
  • 86 (a)
OneToMany
Rangrf 36
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RANGRF 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rangrf 35
  • 86.13 (n)
  • 88.65 (a)
lizard
(Anolis carolinensis)
Reptilia RANGRF 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rangrf 35
  • 55.87 (n)
  • 55.11 (a)
zebrafish
(Danio rerio)
Actinopterygii rangrf 36
  • 44 (a)
OneToOne
rangrf 35
  • 52.27 (n)
  • 47.73 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOG1 36
  • 22 (a)
OneToOne
MOG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69680 35
  • 46.14 (n)
  • 33.9 (a)
rice
(Oryza sativa)
Liliopsida Os04g0459600 35
  • 47.16 (n)
  • 34.09 (a)
Species with no ortholog for RANGRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RANGRF Gene

ENSEMBL:
Gene Tree for RANGRF (if available)
TreeFam:
Gene Tree for RANGRF (if available)

Paralogs for RANGRF Gene

No data available for Paralogs for RANGRF Gene

Variants for RANGRF Gene

Sequence variations from dbSNP and Humsavar for RANGRF Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs6503097 -- 8,286,935(+) AGCTA(C/T)GACTG upstream-variant-2KB
rs8077178 -- 8,286,611(+) TTTTT(C/G)CTCCT upstream-variant-2KB
rs9916737 -- 8,286,990(+) aaaaa(A/C)aaaca upstream-variant-2KB
rs56970209 -- 8,286,924(+) AGGCT(G/T)CAGTG upstream-variant-2KB
rs117150595 -- 8,286,976(+) AGACC(A/G)CCTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RANGRF Gene

Variant ID Type Subtype PubMed ID
nsv833353 CNV Loss 17160897
nsv907661 CNV Gain 21882294

Variation tolerance for RANGRF Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RANGRF Gene

HapMap Linkage Disequilibrium report
RANGRF
Human Gene Mutation Database (HGMD)
RANGRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANGRF Gene

Disorders for RANGRF Gene

MalaCards: The human disease database

(4) MalaCards diseases for RANGRF Gene - From: GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
brugada syndrome 9
  • brgda9
congenital heart block
  • heart block congenital
sick sinus syndrome
  • sinus node infection
brugada syndrome
  • sudden unexpected nocturnal death syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RANGRF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RANGRF
genes like me logo Genes that share disorders with RANGRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RANGRF Gene

Publications for RANGRF Gene

  1. Identification and characterization of the human MOG1 gene. (PMID: 11290418) Marfatia K.A. … Corbett A.H. (Gene 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The perfect storm? Histiocytoid cardiomyopathy and compound CACNA2D1 and RANGRF mutation in a baby. (PMID: 24438356) Cataldo S. … Marziliano N. (Cardiol Young 2015) 3
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  5. Brugada syndrome and p.E61X_RANGRF. (PMID: 24142675) Campuzano O. … Brugada R. (Cardiol J 2014) 3

Products for RANGRF Gene

Sources for RANGRF Gene

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