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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RANGAP1 Gene

protein-coding   GIFtS: 65
GCID: GC22M041641

Ran GTPase Activating Protein 1

(Previous name: segregation distorter homolog (Drosophila))
(Previous symbol: SD)
  2 related diseases
at
MalaCards
 

Aliases
for RANGAP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Ran GTPase Activating Protein 11 2     Ran GTPase-Activating Protein 12
SD1 2 3     Segregation Distorter Homolog2
Segregation Distorter Homolog (Drosophila)1     Segregation Distortion2
Fug12     KIAA18353
RANGAP2     RanGAP13

External Ids:    HGNC: 98541   Entrez Gene: 59052   Ensembl: ENSG000001004017   OMIM: 6023625   UniProtKB: P460603   

Export aliases for RANGAP1 gene to outside databases

Previous GC identifers: GC22M038256 GC22M039884 GC22M039966 GC22M024606


Summaries
for RANGAP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RANGAP1 Gene:
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of
nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine
triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Jul 2013)

GeneCards Summary for RANGAP1 Gene: 
RANGAP1 (Ran GTPase activating protein 1) is a protein-coding gene. Diseases associated with RANGAP1 include herpes simplex, and multiple sclerosis, and among its related super-pathways are Mitotic Anaphase and Mitotic Prometaphase. GO annotations related to this gene include Ran GTPase activator activity and protein binding.

UniProtKB/Swiss-Prot: RAGP1_HUMAN, P46060
Function: GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively
inactive GDP-bound state

Gene Wiki entry for RANGAP1 Gene


Genomic Views
for RANGAP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RANGAP1 gene promoter:
         AhR   CREB   p53   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RANGAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RANGAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RANGAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13

RANGAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RANGAP1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M041641:  view genomic region     (about GC identifiers)

Start:
 41,641,615 bp from pter      End:
 41,682,255 bp from pter
Size:
 40,641 bases      Orientation:
 minus strand

Proteins
for RANGAP1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: RAGP1_HUMAN, P46060 (See protein sequence)
Recommended Name: Ran GTPase-activating protein 1  
Size: 587 amino acids; 63542 Da
Subunit: Homodimer. Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the
ubiquitin-conjugating enzyme E2. Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and
subsequently stabilizes interactions of sumoylated RANGAP1 with RANBP2/NUP358. The SUMO1/RANGAP1/UBC9/NUP358
complex associates with nuclear pore complexes. Interacts with TRAF6
Subcellular location: Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome,
centromere, kinetochore (By similarity). Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=Cytoplasmic
during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic
spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late
anaphase. Mitotic location also requires sumoylation
Sequence caution: Sequence=BAB47464.1; Type=Erroneous initiation;
6/12 PDB 3D structures from and Proteopedia for RANGAP1 (see all 12):
1Z5S (3D)        2GRN (3D)        2GRO (3D)        2GRP (3D)        2GRQ (3D)        2GRR (3D)    
Secondary accessions: Q96JJ2

Explore the universe of human proteins at neXtProt for RANGAP1: NX_P46060

Explore proteomics data for RANGAP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the
    M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis.
    The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBC9, on
    nuclear pore complex (NPC) diassembly and during mitosis
  • UniProtKB: Sumoylated with SUMO1. Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association
    with mitotic spindles and kinetochores during mitosis. Also required for interaction with RANBP2 and is mediated
    by UBC9
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P46060

    • RANGAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RANGAP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265580.1  NP_002874.1  

    ENSEMBL proteins: 
     ENSP00000385866   ENSP00000348577   ENSP00000401470   ENSP00000393407   ENSP00000394787  
     ENSP00000408743   ENSP00000404842   ENSP00000385354  
    Reactome Protein details: P46060
    Human Recombinant Protein Products for RANGAP1: 
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    Novus Biologicals RANGAP1 Protein
    Novus Biologicals RANGAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RANGAP1 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776colocalizes with kinetochore IDA17363900
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000922spindle pole IEA--
    GO:0005643nuclear pore TAS8978815
    GO:0005737cytoplasm TAS8978815

    RANGAP1 for ontologies           About GeneDecksing



    RANGAP1 Antibody Products: 
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    Abcam antibodies for RANGAP1
    Cloud-Clone Corp. Antibodies for RANGAP1 
    ThermoFisher Antibodies for RANGAP1
    LSBio Antibodies in human, mouse, rat for RANGAP1 

    Assay Products for RANGAP1: 
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    Cloud-Clone Corp. ELISAs for RANGAP1 
    Cloud-Clone Corp. CLIAs for RANGAP1

    Protein Domains /
    Families
    for RANGAP1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 2 InterPro protein domains:
     IPR027038 RanGap
     IPR009109 Ran_GTPase_activating_1_C

    Graphical View of Domain Structure for InterPro Entry P46060

    ProtoNet protein and cluster: P46060

    1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

    UniProtKB/Swiss-Prot: RAGP1_HUMAN, P46060
    Similarity: Belongs to the RNA1 family
    Similarity: Contains 6 LRR (leucine-rich) repeats


    RANGAP1 for domains           About GeneDecksing


    Function
    for RANGAP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAGP1_HUMAN, P46060
    Function: GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively
    inactive GDP-bound state

         Genatlas biochemistry entry for RANGAP1:
    Ran GTPase activating protein 1,homolog of yeast Rna1p,component of the nuclear pore complex,highly concentrated
    at its cytoplasmic periphery,conjugating with UBL1 in a ATP dependent fashion,then associating with RANBP2.
    Involved in mRNA processing and transport

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005098Ran GTPase activator activity IEA--
    GO:0005515protein binding IPI17000644
         
    RANGAP1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rangap1):
     embryogenesis  growth/size  mortality/aging 

    RANGAP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RANGAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RANGAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RANGAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RANGAP1 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RANGAP1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RANGAP1:
    hsa-miR-3611 hsa-miR-3153 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmid: RANGAP1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RANGAP1
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of RANGAP1

    Clone
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    Cell Line
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    In Situ Assay
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    Pathways & Interactions
    for RANGAP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RANGAP1 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1M Phase
    		Mitotic Anaphase0.94
    		M Phase0.88
    		Separation of Sister Chromatids0.94
    		Mitotic M-M/G1 phases0.88
    		Mitotic Metaphase and Anaphase0.94
    2Resolution of Sister Chromatid Cohesion
    		Resolution of Sister Chromatid Cohesion0.93
    		Mitotic Prometaphase0.93
    3Cell Cycle
    		Cell Cycle, Mitotic0.84
    		Cell Cycle0.84
    4DNA damage Role of SUMO in p53 regulation
    		Proteolysis Putative SUMO-1 pathway0.33
    54-1BB Pathway
    		SUMO Pathway0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RANGAP1
        Proteolysis Putative SUMO-1 pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RANGAP1
        Ran Pathway
    SUMO Pathway

    1 GeneGo (Thomson Reuters) Pathway for RANGAP1
        Proteolysis Putative SUMO-1 pathway

    3 BioSystems Pathways for RANGAP1
        Signaling events mediated by HDAC Class I
    Sumoylation by RanBP2 regulates transcriptional repression
    Signaling events mediated by HDAC Class II

    5/9        Reactome Pathways for RANGAP1 (see all 9)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase
    Cell Cycle


    1         Kegg Pathway  (Kegg details for RANGAP1):
        RNA transport


    RANGAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RANGAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/903 Interacting proteins for RANGAP1 (P460601, 2, 3 ENSP000003485774) via UniProtKB, MINT, STRING, and/or I2D (see all 903)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GCN1L1Q926162, 3, ENSP000003006484MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000300648
    HIRAP541982, 3, ENSP000002632084MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000263208
    UBE2IP632792, 3, ENSP000003248974MINT-3380689 I2D: score=6 STRING: ENSP00000324897
    BABAM1Q9NWV82, 3, ENSP000003524084MINT-7945693 I2D: score=2 STRING: ENSP00000352408
    EEF1A1P681042, 3MINT-7945693 MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007165signal transduction IEA--
    GO:0032853positive regulation of Ran GTPase activity TAS7878053
    GO:0046826negative regulation of protein export from nucleus IDA16449645

    RANGAP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RANGAP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RANGAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RANGAP1 (RAGP1)

    2 Novoseek inferred chemical compound relationships for RANGAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 63.9 12 10473610 (2), 7744835 (1), 10322113 (1), 8146159 (1) (see all 8)
    lysine 24.3 1 9442102 (1)

    Search CenterWatch for drugs/clinical trials and news about RANGAP1 / RAGP1

    Transcripts
    for RANGAP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RANGAP1 gene (2 alternative transcripts): 
    NM_001278651.1  NM_002883.3  

    Unigene Cluster for RANGAP1:

    Ran GTPase activating protein 1
    Hs.183800  [show with all ESTs]
    Unigene Representative Sequence: BC041396
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000405486(uc003azt.3) ENST00000356244(uc011aoz.2 uc003azu.3)
    ENST00000455915(uc003azs.3) ENST00000446258 ENST00000452543 ENST00000418067
    ENST00000422838 ENST00000407260
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RANGAP1:
    hsa-miR-3611 hsa-miR-3153 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmid: RANGAP1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK302222.1 AK303524.1 BC004990.1 BC014044.2 BC019676.1 BC041396.2 BC048990.1 CR456557.1 
    X82260.1 

    24/36 DOTS entries (see all 36):

    DT.100647773  DT.449648  DT.95154111  DT.100852871  DT.100647772  DT.100645443  DT.92451019  DT.100647777 
    DT.100709463  DT.100711353  DT.100768599  DT.92451021  DT.95272271  DT.100647775  DT.100839566  DT.100859349 
    DT.75170405  DT.100038346  DT.100637492  DT.100854577  DT.100864211  DT.92451015  DT.95272269  DT.100800164 

    24/323 AceView cDNA sequences (see all 323):

    BM553423 CR599804 BM550926 BC012882 BQ641923 CN482804 AA709404 BC068590 
    BI828416 BM550690 BQ061240 CR456557 BQ893444 BM551464 BM542955 BC004990 
    BM553409 BC019676 BP430437 AA351030 BQ053784 BM810912 BU190935 BQ424384 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RANGAP1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^
    SP1:                                      -     -     -     -     -     -     -                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                        -   
    SP4:                                      -     -           -     -     -     -                                                                                 
    SP5:                                      -     -           -           -     -                                                                                 

    ExUns: 15a · 15b ^ 16a · 16b ^ 17a · 17b
    SP1:                                    
    SP2:  -                 -               
    SP3:  -                 -               
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RANGAP1

    Expression
    for RANGAP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RANGAP1 expression in normal human tissues (normalized intensities)      RANGAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCCCCTT
    RANGAP1 Expression
    About this image


    RANGAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See RANGAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RANGAP1

    SOURCE GeneReport for Unigene cluster: Hs.183800

    UniProtKB/Swiss-Prot: RAGP1_HUMAN, P46060
    Tissue specificity: Highly expressed in brain, thymus and testis

        SABiosciences Expression via Pathway-Focused PCR Array including RANGAP1: 
              Multiple Sclerosis in human mouse rat

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    Orthologs
    for RANGAP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RANGAP1 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rangap11 , 5 RAN GTPase activating protein 11, 5 86.09(n)1
    89.1(a)1    		   15 (38.21 cM)5
    193871  NM_001146174.11  NP_001139646.11 
     817042485 
    chicken
    (Gallus gallus)    		 Aves RANGAP11 Ran GTPase activating protein 1 75.46(n)
    82.24(a)    		   417997  NM_001006237.1  NP_001006237.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RANGAP16
    		 Uncharacterized protein
    		 77(a)
    		 1 ↔ 1
    		 5(26276662-26299909)
    African clawed frog
    (Xenopus laevis)    		 Amphibia rangap1-prov2 RAN GTPase activating protein 1 75.33(n)    BC043982.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.265582 Danio rerio cDNA clone MGC66165 IMAGE5600717, complete more 73.92(n)    BC054654.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RanGap1 Ran GTPase activating protein 53.65(n)
    42.29(a)    		   35223  NM_057364.3  NP_476712.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ran-23 RNA production/processing 51(a)     --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RNA1(YMR235C)4
    RNA11    		 GTPase activating protein (GAP) for Gsp1p, involved more4
    Rna1p1    		 45.65(n)1
    33.61(a)1    		   13(742735-741512)4
    8552751, 4  NP_013962.11, 4 


    ENSEMBL Gene Tree for RANGAP1 (if available)
    TreeFam Gene Tree for RANGAP1 (if available)

    Paralogs
    for RANGAP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RANGAP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/932 SNPs in RANGAP1 are shown (see all 932)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs60022961,2
    		C--41641170(+) ACCTAC/TGTGGC 1 -- ds50010--------
    rs96373391,2
    		H--41641282(+) GGGTAG/AGAGGT 1 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs1179836671,2
    		C,F--41641311(+) TGTCCT/GCACAT 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs60022981,2
    		C,F,H--41641570(+) TACAAC/TGGCCC 1 -- ds500125Minor allele frequency- T:0.08NS EA NA WA CSA 2552
    rs1831742091,2
    		--41641649(+) GCCCCC/TGGGCA 1 -- ut310--------
    rs1468954531,2
    		--41641672(+) ACACAC/GAGCAC 1 -- ut310--------
    rs1878599211,2
    		--41641703(+) GTCACA/GGGTGC 1 -- ut310--------
    rs119136891,2
    		H--41641751(+) TACCGC/GTCCCC 1 -- ut31 ese30--------
    rs577124731,2
    		C--41641784(+) GCAGCA/GTCCAG 1 -- ut310--------
    rs738857531,2
    		C,F--41641924(+) GGTCCG/AGGGCC 1 -- ut313Minor allele frequency- A:0.18WA 122

    HapMap Linkage Disequilibrium report for RANGAP1 (41641615 - 41682255 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for RANGAP1 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3638CNV Insertion18451855
    nsv915118CNV Loss21882294
    nsv915117CNV Loss21882294
    nsv834207CNV Loss17160897
    nsv915119CNV Loss21882294
    nsv915120CNV Loss21882294
    nsv915116CNV Loss21882294
    nsv524585CNV Loss19592680
    nsv516925CNV Loss19592680
    nsv3637CNV Loss18451855

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    Disorders / Diseases
    for RANGAP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 602362    OMIM disorders: --

    2 diseases for RANGAP1:    About MalaCards
    herpes simplex    multiple sclerosis


    RANGAP1 for disorders           About GeneDecksing


    Export disorders for RANGAP1 gene to outside databases

    Publications
    for RANGAP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RANGAP1 gene, integrated from 9 sources (see all 134):
    (articles sorted by number of sources associating them with RANGAP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. (PubMed id 7878053)1, 2, 3, 9 Bischoff F.R.... Ponstingl H. (1995)
    2. Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1. (PubMed id 8973340)1, 2, 9 Krebber H. and Ponstingl H. (1996)
    3. RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. (PubMed id 15037602)1, 2, 9 Swaminathan S....Melchior F. (2004)
    4. Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9- Nup358 complex. (PubMed id 15931224)1, 2, 9 Reverter D. and Lima C.D. (2005)
    5. Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. (PubMed id 18093978)1, 2 Pham L.V....Ford R.J. (2008)
    6. SUMO protease SENP1 induces isomerization of the scissile peptide bond. (PubMed id 17099698)1, 2 Shen L....Hay R.T. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. (PubMed id 11854305)1, 2 Joseph J.... Dasso M. (2002)

    External Searches for RANGAP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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    Genome Databases showing RANGAP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5905 HGNC: 9854 AceView: RANGAP1 Ensembl:ENSG00000100401 euGenes: HUgn5905
    ECgene: RANGAP1 Kegg: 5905 H-InvDB: RANGAP1

    Other Databases showing RANGAP1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1835

    Specialized Databases showing RANGAP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RANGAP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RANGAP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RANGAP1 gene:
    Search GeneIP for patents involving RANGAP1

    GeneCards and IP:
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