Aliases for RANGAP1 Gene
Aliases for RANGAP1 Gene
External Ids for RANGAP1 Gene
- HGNC: 9854
- Entrez Gene: 5905
- Ensembl: ENSG00000100401
- OMIM: 602362
- UniProtKB: P46060
Previous HGNC Symbols for RANGAP1 Gene
- SD
Previous GeneCards Identifiers for RANGAP1 Gene
- GC22M038256
- GC22M039884
- GC22M039966
- GC22M041641
- GC22M024606
Summaries for RANGAP1 Gene
-
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for RANGAP1 Gene
RANGAP1 (Ran GTPase Activating Protein 1) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Ran Pathway. GO annotations related to this gene include GTPase activator activity.
UniProtKB/Swiss-Prot for RANGAP1 Gene
-
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANGAP1 Gene
Genomics for RANGAP1 Gene
Regulatory Elements for RANGAP1 Gene
Enhancers for RANGAP1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around RANGAP1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the RANGAP1 gene promoter:
Regulatory Element Products
Genomic Location for RANGAP1 Gene
- Chromosome:
- 22
- Start:
- 41,244,777 bp from pter
- End:
- 41,302,210 bp from pter
- Size:
- 57,434 bases
- Orientation:
- Minus strand
Genomic View for RANGAP1 Gene
Genes around RANGAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.2 by Ensembl
- 22q13.2 by Entrez Gene
- 22q13.2 by HGNC
RANGAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RANGAP1 Gene
Proteins for RANGAP1 Gene
-
Protein details for RANGAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46060-RAGP1_HUMAN
- Recommended name:
- Ran GTPase-activating protein 1
- Protein Accession:
- P46060
- Q96JJ2
Protein attributes for RANGAP1 Gene
- Size:
- 587 amino acids
- Molecular mass:
- 63542 Da
- Quaternary structure:
-
- Homodimer. Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the ubiquitin-conjugating enzyme E2. Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and subsequently stabilizes interactions of sumoylated RANGAP1 with RANBP2/NUP358. The SUMO1/RANGAP1/UBC9/NUP358 complex associates with nuclear pore complexes. Interacts with TRAF6.
- SequenceCaution:
-
- Sequence=BAB47464.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for RANGAP1 Gene
Post-translational modifications for RANGAP1 Gene
- Phosphorylated occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBC9, on nuclear pore complex (NPC) diassembly and during mitosis.
- Sumoylated with SUMO1. Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis. Also required for interaction with RANBP2 and is mediated by UBC9.
- Ubiquitination at Lys296 and isoforms=452
- Modification sites at PhosphoSitePlus
Other Protein References for RANGAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RANGAP1 (RanGAP1)
- Cell Signaling Technology (CST) Antibodies for RANGAP1 (RANGAP1)
-
Custom Antibody ServicesOriGene Antibodies for RANGAP1
- Novus Biologicals Antibodies for RANGAP1
- Invitrogen Antibodies for RANGAP1
- antibodies-online Antibodies for RANGAP1: See all 85
- GeneTex RANGAP1 antibody for RANGAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RANGAP1
Protein Products
-
OriGene Purified Proteins for RANGAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for RANGAP1
- Origene Custom Protein Services for RANGAP1
- antibodies-online Proteins for RANGAP1: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for RANGAP1
Assay Products
- antibodies-online Kits for RANGAP1: See all 2
No data available for DME Specific Peptides for RANGAP1 Gene
Domains & Families for RANGAP1 Gene
Protein Domains for RANGAP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RANGAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P46060- Family:
-
- Belongs to the RNA1 family.
No data available for Gene Families for RANGAP1 Gene
Function for RANGAP1 Gene
Molecular function for RANGAP1 Gene
- GENATLAS Biochemistry:
- Ran GTPase activating protein 1,homolog of yeast Rna1p,component of the nuclear pore complex,highly concentrated at its cytoplasmic periphery,conjugating with UBL1 in a ATP dependent fashion,then associating with RANBP2. Involved in mRNA processing and transport
- UniProtKB/Swiss-Prot Function:
- GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 26308891 |
| GO:0005096 | GTPase activator activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 17000644 |
| GO:0008536 | Ran GTPase binding | IEA | -- |
| GO:0031625 | ubiquitin protein ligase binding | IEA | -- |
Phenotypes for RANGAP1 Gene
- MGI mutant phenotypes for RANGAP1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RANGAP1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RANGAP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RANGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
- Search ViGene Biosciences for RANGAP1
CRISPR Products
-
OriGene CRISPR knockouts for RANGAP1
-
Applied Biological Materials CRISPR for RANGAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
- GenScript: Design CRISPR guide RNA sequences for RANGAP1
miRNA for RANGAP1 Gene
- miRTarBase miRNAs that target RANGAP1
-
- hsa-mir-16-5p (MIRT031630)
- hsa-mir-1301-3p (MIRT036035)
- hsa-mir-331-3p (MIRT043425)
- hsa-mir-92a-3p (MIRT049661)
- hsa-mir-31-5p (MIRT049887)
- hsa-mir-4730 (MIRT453756)
- hsa-mir-7847-3p (MIRT453757)
- hsa-mir-6851-5p (MIRT453758)
- hsa-mir-6880-5p (MIRT453759)
- hsa-mir-3689d (MIRT453760)
- hsa-mir-7854-3p (MIRT453761)
- hsa-mir-3934-5p (MIRT453762)
- hsa-mir-764 (MIRT453763)
- hsa-mir-125a-3p (MIRT453764)
- hsa-mir-5197-5p (MIRT453765)
- hsa-mir-6749-3p (MIRT612590)
- hsa-mir-4707-3p (MIRT612591)
- hsa-mir-18a-3p (MIRT612592)
- hsa-mir-324-3p (MIRT612593)
- hsa-mir-1913 (MIRT612594)
- hsa-mir-150-5p (MIRT612595)
- hsa-mir-186-3p (MIRT612596)
- hsa-mir-520h (MIRT612597)
- hsa-mir-520g-3p (MIRT612598)
- hsa-mir-520e (MIRT612599)
- hsa-mir-520d-3p (MIRT612600)
- hsa-mir-520c-3p (MIRT612601)
- hsa-mir-520b (MIRT612602)
- hsa-mir-520a-3p (MIRT612603)
- hsa-mir-373-3p (MIRT612604)
- hsa-mir-372-3p (MIRT612605)
- hsa-mir-302e (MIRT612606)
- hsa-mir-302d-3p (MIRT612607)
- hsa-mir-302c-3p (MIRT612608)
- hsa-mir-302b-3p (MIRT612609)
- hsa-mir-302a-3p (MIRT612610)
- hsa-mir-93-5p (MIRT612611)
- hsa-mir-526b-3p (MIRT612612)
- hsa-mir-519d-3p (MIRT612613)
- hsa-mir-20b-5p (MIRT612614)
- hsa-mir-20a-5p (MIRT612615)
- hsa-mir-17-5p (MIRT612616)
- hsa-mir-106b-5p (MIRT612617)
- hsa-mir-106a-5p (MIRT612618)
- hsa-mir-129-5p (MIRT625442)
- hsa-mir-8055 (MIRT625443)
- hsa-mir-6864-3p (MIRT625444)
- hsa-mir-3672 (MIRT625445)
- hsa-mir-4753-3p (MIRT625446)
- hsa-mir-6873-3p (MIRT625447)
- hsa-mir-155-3p (MIRT625448)
- hsa-mir-223-3p (MIRT625449)
- hsa-mir-4697-3p (MIRT625450)
- hsa-mir-4524a-3p (MIRT625451)
- hsa-mir-130b-5p (MIRT625452)
- hsa-mir-6817-3p (MIRT625453)
- hsa-mir-7110-3p (MIRT625454)
- hsa-mir-1182 (MIRT625455)
- hsa-mir-4524b-3p (MIRT625456)
- hsa-mir-6796-3p (MIRT625457)
- hsa-mir-3159 (MIRT625458)
- hsa-mir-7151-3p (MIRT630565)
- hsa-mir-5095 (MIRT630566)
- hsa-mir-4438 (MIRT630567)
- hsa-mir-3149 (MIRT639235)
- hsa-mir-197-3p (MIRT639236)
- hsa-mir-4711-5p (MIRT639237)
- hsa-mir-7112-3p (MIRT639238)
- hsa-mir-4267 (MIRT639239)
- hsa-mir-153-5p (MIRT639240)
- hsa-mir-1250-3p (MIRT639241)
- hsa-mir-500b-3p (MIRT639242)
- hsa-mir-3124-3p (MIRT709232)
- hsa-mir-1238-3p (MIRT709233)
- hsa-mir-670-3p (MIRT709234)
- hsa-mir-452-3p (MIRT709235)
- hsa-mir-627-3p (MIRT709236)
- hsa-mir-483-3p (MIRT709237)
- hsa-mir-664a-3p (MIRT709238)
- hsa-mir-3142 (MIRT709239)
- hsa-mir-1245b-5p (MIRT709240)
- hsa-mir-32-3p (MIRT709241)
- hsa-mir-4753-5p (MIRT709242)
miRNA Products
- Search ViGene Biosciences for RANGAP1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for RANGAP1
- Browse OriGene Inhibitory RNA Products For RANGAP1
-
ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
Clone Products
-
OriGene ORF clones in human for RANGAP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RANGAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RANGAP1
- VectorBuilder custom plasmid, inducible vectors for RANGAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RANGAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for RANGAP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RANGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANGAP1 Gene
Localization for RANGAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RANGAP1 Gene
- Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | colocalizes_with kinetochore | IEA,IDA | 17363900 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0000922 | spindle pole | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005635 | nuclear envelope | TAS | -- |
Pathways & Interactions for RANGAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.92
.65
|
.45
|
| 2 | Cell Cycle, Mitotic |
.83
|
.60
|
| 3 | Transport of the SLBP independent Mature mRNA | ||
| 4 | Mitotic Metaphase and Anaphase |
.94
|
|
| 5 | Mitotic Prometaphase | ||
Pathways by source for RANGAP1 Gene
3 BioSystems pathways for RANGAP1 Gene
25 Reactome pathways for RANGAP1 Gene
1 KEGG pathway for RANGAP1 Gene
1 GeneGo (Thomson Reuters) pathway for RANGAP1 Gene
2 Qiagen pathways for RANGAP1 Gene
Interacting Proteins for RANGAP1 Gene
Selected Interacting proteins:
P46060-RAGP1_HUMAN
ENSP00000348577
for RANGAP1 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007062 | sister chromatid cohesion | TAS | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0016925 | protein sumoylation | TAS | -- |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
| GO:0046826 | negative regulation of protein export from nucleus | IDA | 16449645 |
Transcripts for RANGAP1 Gene
mRNA/cDNA for RANGAP1 Gene
- (17) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (323) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RANGAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RANGAP1
-
Applied Biological Materials CRISPR for RANGAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
- GenScript: Design CRISPR guide RNA sequences for RANGAP1
miRNA Products
- Search ViGene Biosciences for RANGAP1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for RANGAP1
- Browse OriGene Inhibitory RNA Products For RANGAP1
-
ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
Clone Products
-
OriGene ORF clones in human for RANGAP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RANGAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RANGAP1
- VectorBuilder custom plasmid, inducible vectors for RANGAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RANGAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
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| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - | - | |||||||||
| SP3: | - | - | |||||||||
| SP4: | |||||||||||
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| SP11: | |||||||||||
| SP12: |
Expression for RANGAP1 Gene
This gene is overexpressed in Bone (14.4), Nasal epithelium (8.0), and Lymph node (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANGAP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RANGAP1 Gene:
RANGAP1SOURCE GeneReport for Unigene cluster for RANGAP1 Gene:
Hs.183800mRNA Expression by UniProt/SwissProt for RANGAP1 Gene:
P46060-RAGP1_HUMAN
Tissue specificity:
Highly expressed in brain, thymus and testis.
Evidence on tissue expression from TISSUES for RANGAP1 Gene
- Nervous system(4.9)
- Kidney(4.3)
- Skin(4.2)
- Lung(2.7)
- Intestine(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for RANGAP1
-
OriGene qPCR primer pairs for RANGAP1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANGAP1 Gene
Orthologs for RANGAP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RANGAP1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | RANGAP1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | RANGAP1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rangap1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Rangap1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RANGAP1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RANGAP1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RANGAP1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | RANGAP1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rangap1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | rangap1-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rangap1a 34 35 |
|
||
| rangap1b 35 |
|
OneToMany | |||
| Dr.26558 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1664 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | RanGap 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | ran-2 36 35 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR525C 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RNA1 34 35 37 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F25036g 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9560 35 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03207 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rna1 34 |
|
- Species where no ortholog for RANGAP1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RANGAP1 Gene
No data available for Paralogs for RANGAP1 Gene
Variants for RANGAP1 Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000026024 | -- | 41,292,518(+) | GACTT(A/T)GGGAG | intron-variant | |
| rs1000107155 | -- | 41,272,476(+) | GAGAA(C/T)ACTGA | intron-variant | |
| rs1000134488 | -- | 41,257,718(+) | CGGCT(C/T)AGGAG | intron-variant | |
| rs1000145489 | -- | 41,289,152(+) | CTGAC(C/T)TGGTG | intron-variant, upstream-variant-2KB | |
| rs1000187188 | -- | 41,257,510(+) | CTCAG(A/G)AGGCT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv3637 | CNV | deletion | 18451855 |
| nsv3638 | CNV | insertion | 18451855 |
| nsv459888 | CNV | gain | 19166990 |
| nsv479885 | CNV | novel sequence insertion | 20440878 |
| nsv516925 | CNV | loss | 19592680 |
| nsv524585 | CNV | loss | 19592680 |
| nsv589049 | CNV | gain | 21841781 |
| nsv589050 | CNV | gain | 21841781 |
| nsv817997 | CNV | gain | 17921354 |
| nsv834207 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.35;
41.77% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RANGAP1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANGAP1 Gene
Disorders for RANGAP1 Gene
Relevant External Links for RANGAP1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- RANGAP1
No disorders were found for RANGAP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANGAP1 Gene
Publications for RANGAP1 Gene
- Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. (PMID: 7878053) Bischoff F.R. … Ponstingl H. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 22 64
- Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9- Nup358 complex. (PMID: 15931224) Reverter D. … Lima C.D. (Nature 2005) 3 4 22 64
- RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. (PMID: 15037602) Swaminathan S. … Melchior F. (J. Cell Biol. 2004) 3 4 22 64
- Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1. (PMID: 8973340) Krebber H. … Ponstingl H. (Gene 1996) 3 4 22 64
- Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. (PMID: 19285941) Zhu S. … Matunis M.J. (Mol. Cell 2009) 3 22 64
Products for RANGAP1 Gene
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- Custom Antibody ServicesOriGene Antibodies for RANGAP1
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- Browse Antibodies at Cloud-Clone Corp.
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- Invitrogen Antibodies for RANGAP1
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- antibodies-online Antibodies for RANGAP1: See all 85
- antibodies-online Kits for RANGAP1: See all 2
- antibodies-online Proteins for RANGAP1: See all 6
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- GeneTex RANGAP1 antibody for RANGAP1
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- ViGene Biosciences adenoviral particle packaged cDNA for RANGAP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RANGAP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for RANGAP1
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- Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
- Cyagen custom Knockout/knockin (KOKI) mouse models for RANGAP1
- VectorBuilder custom plasmid, inducible vectors for RANGAP1
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for RANGAP1 Gene
- (1) GeneCards
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- (35) PanEnsembl
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- (38) FlyBase
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- (40) Pseudogene
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- (44) GeneTests
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- (48) BGMUT
- (49) HuGE
- (50) eBioscience
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- (53) GenBank
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- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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- (77) Proteopedia
- (78) MOPED
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- (82) GeneGo (Thomson Reuters)
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- (100) COMPARTMENTS
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- (157) CrownBio