Aliases for RANGAP1 Gene
Aliases for RANGAP1 Gene
External Ids for RANGAP1 Gene
- HGNC: 9854
- Entrez Gene: 5905
- Ensembl: ENSG00000100401
- OMIM: 602362
- UniProtKB: P46060
Previous HGNC Symbols for RANGAP1 Gene
- SD
Previous GeneCards Identifiers for RANGAP1 Gene
- GC22M038256
- GC22M039884
- GC22M039966
- GC22M041641
- GC22M024606
Summaries for RANGAP1 Gene
-
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for RANGAP1 Gene
RANGAP1 (Ran GTPase Activating Protein 1) is a Protein Coding gene. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTPase activator activity.
UniProtKB/Swiss-Prot for RANGAP1 Gene
-
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
Additional gene information for RANGAP1 Gene
- Monarch Initiative
- Search for RANGAP1 at DataMed
- Search for RANGAP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANGAP1 Gene
Genomics for RANGAP1 Gene
GeneHancer (GH) Regulatory Elements for RANGAP1 Gene
Regulatory Element Products
Genomic Locations for RANGAP1 Gene
- chr22:41,244,777-41,302,210
- (GRCh38/hg38)
- Size:
- 57,434 bases
- Orientation:
- Minus strand
- chr22:41,641,615-41,682,255
- (GRCh37/hg19)
Genomic View for RANGAP1 Gene
- Cytogenetic band:
-
- 22q13.2 by Ensembl
- 22q13.2 by Entrez Gene
- 22q13.2 by HGNC


RefSeq DNA sequence for RANGAP1 Gene
Proteins for RANGAP1 Gene
-
Protein details for RANGAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46060-RAGP1_HUMAN
- Recommended name:
- Ran GTPase-activating protein 1
- Protein Accession:
- P46060
- Q96JJ2
Protein attributes for RANGAP1 Gene
- Size:
- 587 amino acids
- Molecular mass:
- 63542 Da
- Quaternary structure:
-
- Homodimer. Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the ubiquitin-conjugating enzyme E2. Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and subsequently stabilizes interactions of sumoylated RANGAP1 with RANBP2/NUP358. The SUMO1/RANGAP1/UBC9/NUP358 complex associates with nuclear pore complexes. Interacts with TRAF6.
- SequenceCaution:
-
- Sequence=BAB47464.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for RANGAP1 Gene
Post-translational modifications for RANGAP1 Gene
- Phosphorylated occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBC9, on nuclear pore complex (NPC) diassembly and during mitosis.
- Sumoylated with SUMO1. Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis. Also required for interaction with RANBP2 and is mediated by UBC9.
- Ubiquitination at isoforms=296 and isoforms=452
Other Protein References for RANGAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RANGAP1 (RanGAP1)
- Cell Signaling Technology (CST) Antibodies for RANGAP1 (RANGAP1)
- Novus Biologicals Antibodies for RANGAP1
-
Abcam antibodies for RANGAP1
- Invitrogen Antibodies for RANGAP1
- GeneTex RANGAP1 antibody for RANGAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RANGAP1
Protein Products
-
OriGene Purified Proteins for RANGAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for RANGAP1
- Origene Custom Protein Services for RANGAP1
- Search GeneTex for Proteins for RANGAP1
-
Abcam proteins for RANGAP1
Assay Products
No data available for DME Specific Peptides for RANGAP1 Gene
Domains & Families for RANGAP1 Gene
Gene Families for RANGAP1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transporters
Protein Domains for RANGAP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RANGAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P46060- Family:
-
- Belongs to the RNA1 family.
Function for RANGAP1 Gene
Molecular function for RANGAP1 Gene
- GENATLAS Biochemistry:
- Ran GTPase activating protein 1,homolog of yeast Rna1p,component of the nuclear pore complex,highly concentrated at its cytoplasmic periphery,conjugating with UBL1 in a ATP dependent fashion,then associating with RANBP2. Involved in mRNA processing and transport
- UniProtKB/Swiss-Prot Function:
- GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
Phenotypes From GWAS Catalog for RANGAP1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IDA | 26308891 |
GO:0005096 | GTPase activator activity | IEA | -- |
GO:0005515 | protein binding | IPI | 14729961 |
GO:0008536 | Ran GTPase binding | IEA | -- |
GO:0031625 | ubiquitin protein ligase binding | IEA | -- |
Phenotypes for RANGAP1 Gene
- MGI mutant phenotypes for RANGAP1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RANGAP1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for RANGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
- Search ViGene Biosciences for RANGAP1
CRISPR Products
-
OriGene CRISPR knockouts for RANGAP1
- genomics-online: gRNA clones - Search results for available RANGAP1 gene related products
- Applied Biological Materials CRISPR for RANGAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
- GenScript: Design CRISPR guide RNA sequences for RANGAP1
miRNA for RANGAP1 Gene
- miRTarBase miRNAs that target RANGAP1
-
- hsa-mir-16-5p (MIRT031630)
- hsa-mir-1301-3p (MIRT036035)
- hsa-mir-331-3p (MIRT043425)
- hsa-mir-92a-3p (MIRT049661)
- hsa-mir-31-5p (MIRT049887)
- hsa-mir-4730 (MIRT453756)
- hsa-mir-7847-3p (MIRT453757)
- hsa-mir-6851-5p (MIRT453758)
- hsa-mir-6880-5p (MIRT453759)
- hsa-mir-3689d (MIRT453760)
- hsa-mir-7854-3p (MIRT453761)
- hsa-mir-3934-5p (MIRT453762)
- hsa-mir-764 (MIRT453763)
- hsa-mir-125a-3p (MIRT453764)
- hsa-mir-5197-5p (MIRT453765)
- hsa-mir-6749-3p (MIRT612590)
- hsa-mir-4707-3p (MIRT612591)
- hsa-mir-18a-3p (MIRT612592)
- hsa-mir-324-3p (MIRT612593)
- hsa-mir-1913 (MIRT612594)
- hsa-mir-150-5p (MIRT612595)
- hsa-mir-186-3p (MIRT612596)
- hsa-mir-520h (MIRT612597)
- hsa-mir-520g-3p (MIRT612598)
- hsa-mir-520e (MIRT612599)
- hsa-mir-520d-3p (MIRT612600)
- hsa-mir-520c-3p (MIRT612601)
- hsa-mir-520b (MIRT612602)
- hsa-mir-520a-3p (MIRT612603)
- hsa-mir-373-3p (MIRT612604)
- hsa-mir-372-3p (MIRT612605)
- hsa-mir-302e (MIRT612606)
- hsa-mir-302d-3p (MIRT612607)
- hsa-mir-302c-3p (MIRT612608)
- hsa-mir-302b-3p (MIRT612609)
- hsa-mir-302a-3p (MIRT612610)
- hsa-mir-93-5p (MIRT612611)
- hsa-mir-526b-3p (MIRT612612)
- hsa-mir-519d-3p (MIRT612613)
- hsa-mir-20b-5p (MIRT612614)
- hsa-mir-20a-5p (MIRT612615)
- hsa-mir-17-5p (MIRT612616)
- hsa-mir-106b-5p (MIRT612617)
- hsa-mir-106a-5p (MIRT612618)
- hsa-mir-129-5p (MIRT625442)
- hsa-mir-8055 (MIRT625443)
- hsa-mir-6864-3p (MIRT625444)
- hsa-mir-3672 (MIRT625445)
- hsa-mir-4753-3p (MIRT625446)
- hsa-mir-6873-3p (MIRT625447)
- hsa-mir-155-3p (MIRT625448)
- hsa-mir-223-3p (MIRT625449)
- hsa-mir-4697-3p (MIRT625450)
- hsa-mir-4524a-3p (MIRT625451)
- hsa-mir-130b-5p (MIRT625452)
- hsa-mir-6817-3p (MIRT625453)
- hsa-mir-7110-3p (MIRT625454)
- hsa-mir-1182 (MIRT625455)
- hsa-mir-4524b-3p (MIRT625456)
- hsa-mir-6796-3p (MIRT625457)
- hsa-mir-3159 (MIRT625458)
- hsa-mir-7151-3p (MIRT630565)
- hsa-mir-5095 (MIRT630566)
- hsa-mir-4438 (MIRT630567)
- hsa-mir-3149 (MIRT639235)
- hsa-mir-197-3p (MIRT639236)
- hsa-mir-4711-5p (MIRT639237)
- hsa-mir-7112-3p (MIRT639238)
- hsa-mir-4267 (MIRT639239)
- hsa-mir-153-5p (MIRT639240)
- hsa-mir-1250-3p (MIRT639241)
- hsa-mir-500b-3p (MIRT639242)
- hsa-mir-3124-3p (MIRT709232)
- hsa-mir-1238-3p (MIRT709233)
- hsa-mir-670-3p (MIRT709234)
- hsa-mir-452-3p (MIRT709235)
- hsa-mir-627-3p (MIRT709236)
- hsa-mir-483-3p (MIRT709237)
- hsa-mir-664a-3p (MIRT709238)
- hsa-mir-3142 (MIRT709239)
- hsa-mir-1245b-5p (MIRT709240)
- hsa-mir-32-3p (MIRT709241)
- hsa-mir-4753-5p (MIRT709242)
- hsa-mir-1207-5p (MIRT736052)
- hsa-mir-1286 (MIRT737062)
- hsa-mir-3158-3p (MIRT740465)
- hsa-mir-4323 (MIRT744052)
- hsa-mir-4436b-3p (MIRT744471)
- hsa-mir-4514 (MIRT745719)
- hsa-mir-4632-5p (MIRT746280)
- hsa-mir-4645-5p (MIRT746421)
- hsa-mir-4673 (MIRT746863)
- hsa-mir-4685-5p (MIRT746969)
- hsa-mir-4692 (MIRT747126)
- hsa-mir-4763-3p (MIRT748560)
- hsa-mir-6132 (MIRT752331)
- hsa-mir-6721-5p (MIRT753830)
- hsa-mir-6735-5p (MIRT754183)
- hsa-mir-6753-5p (MIRT754679)
- hsa-mir-6808-5p (MIRT756595)
- hsa-mir-6836-5p (MIRT757225)
- hsa-mir-6837-5p (MIRT757251)
- hsa-mir-6879-5p (MIRT758272)
- hsa-mir-6886-5p (MIRT758562)
- hsa-mir-6893-5p (MIRT758740)
- hsa-mir-7843-5p (MIRT759772)
- hsa-mir-7855-5p (MIRT759957)
- hsa-mir-873-5p (MIRT760323)
- hsa-mir-940 (MIRT760836)
miRNA Products
- Search ViGene Biosciences for RANGAP1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RANGAP1
- Browse OriGene Inhibitory RNA Products For RANGAP1
- genomics-online: shRNA clones - Search results for available RANGAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
Clone Products
- Sino Biological Human cDNA Clone for RANGAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RANGAP1
- genomics-online: cdna clones - Search results for available RANGAP1 gene related products
- orf clones - Search results for available RANGAP1 gene related products
- Applied Biological Materials Clones for RANGAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for RANGAP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RANGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANGAP1 Gene
Localization for RANGAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RANGAP1 Gene
- Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.
- Cytosol (4)
- Nuclear membrane (4)
- Vesicles (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000776 | colocalizes_with kinetochore | IDA,IEA | 17363900 |
GO:0000777 | condensed chromosome kinetochore | IEA | -- |
GO:0000922 | spindle pole | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005635 | nuclear envelope | TAS | -- |
Pathways & Interactions for RANGAP1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HIV Life Cycle |
.92
.65
|
.45
|
2 | Cell Cycle, Mitotic |
.83
|
.60
|
3 | Transport of the SLBP independent Mature mRNA | ||
4 | Mitotic Metaphase and Anaphase |
.94
|
|
5 | Mitotic Prometaphase |
Pathways by source for RANGAP1 Gene
3 BioSystems pathways for RANGAP1 Gene
25 Reactome pathways for RANGAP1 Gene
1 KEGG pathway for RANGAP1 Gene
1 GeneGo (Thomson Reuters) pathway for RANGAP1 Gene
2 Qiagen pathways for RANGAP1 Gene
Interacting Proteins for RANGAP1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007062 | sister chromatid cohesion | TAS | -- |
GO:0007165 | signal transduction | TAS,IEA | -- |
GO:0016925 | protein sumoylation | TAS | -- |
GO:0043547 | positive regulation of GTPase activity | IEA | -- |
GO:0046826 | negative regulation of protein export from nucleus | IDA | 16449645 |
Transcripts for RANGAP1 Gene
mRNA/cDNA for RANGAP1 Gene
- (17) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (323) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RANGAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RANGAP1
- genomics-online: gRNA clones - Search results for available RANGAP1 gene related products
- Applied Biological Materials CRISPR for RANGAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
- GenScript: Design CRISPR guide RNA sequences for RANGAP1
miRNA Products
- Search ViGene Biosciences for RANGAP1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RANGAP1
- Browse OriGene Inhibitory RNA Products For RANGAP1
- genomics-online: shRNA clones - Search results for available RANGAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
Clone Products
- Sino Biological Human cDNA Clone for RANGAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RANGAP1
- genomics-online: cdna clones - Search results for available RANGAP1 gene related products
- orf clones - Search results for available RANGAP1 gene related products
- Applied Biological Materials Clones for RANGAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: |
ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: | - | - | |||||||||
SP3: | - | - | |||||||||
SP4: | |||||||||||
SP5: | |||||||||||
SP6: | |||||||||||
SP7: | |||||||||||
SP8: | |||||||||||
SP9: | |||||||||||
SP10: | |||||||||||
SP11: | |||||||||||
SP12: |
Expression for RANGAP1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANGAP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of RANGAP1 Gene:
RANGAP1SOURCE GeneReport for Unigene cluster for RANGAP1 Gene:
Hs.183800mRNA Expression by UniProt/SwissProt for RANGAP1 Gene:
P46060-RAGP1_HUMANEvidence on tissue expression from TISSUES for RANGAP1 Gene
- Nervous system(4.9)
- Kidney(4.3)
- Skin(4.2)
- Lung(2.7)
- Intestine(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for RANGAP1
-
OriGene qPCR primer pairs for RANGAP1
- genomics-online: primer clones - Search results for available RANGAP1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANGAP1 Gene
Orthologs for RANGAP1 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | RANGAP1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | RANGAP1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | RANGAP1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Rangap1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Rangap1 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | RANGAP1 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | RANGAP1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | RANGAP1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | RANGAP1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | rangap1 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | rangap1-prov 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | rangap1a 33 34 |
|
||
rangap1b 34 |
|
OneToMany | |||
Dr.26558 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1664 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | RanGap 34 |
|
OneToOne | |
worm (Caenorhabditis elegans) |
Secernentea | ran-2 35 34 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR525C 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RNA1 33 34 36 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F25036g 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9560 34 |
|
OneToOne | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU03207 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rna1 33 |
|
- Species where no ortholog for RANGAP1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RANGAP1 Gene
No data available for Paralogs for RANGAP1 Gene
Variants for RANGAP1 Gene
SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000026024 | -- | 41,292,518(-) | T/A | genic_upstream_transcript_variant, intron_variant | |
rs1000107155 | -- | 41,272,476(-) | C/T | intron_variant | |
rs1000134488 | -- | 41,257,718(-) | C/T | intron_variant | |
rs1000145489 | -- | 41,289,152(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000187188 | -- | 41,257,510(-) | A/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv3637 | CNV | deletion | 18451855 |
nsv3638 | CNV | insertion | 18451855 |
nsv459888 | CNV | gain | 19166990 |
nsv479885 | CNV | novel sequence insertion | 20440878 |
nsv516925 | CNV | loss | 19592680 |
nsv524585 | CNV | loss | 19592680 |
nsv589049 | CNV | gain | 21841781 |
nsv589050 | CNV | gain | 21841781 |
nsv817997 | CNV | gain | 17921354 |
nsv834207 | CNV | loss | 17160897 |
Additional Variant Information for RANGAP1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANGAP1 Gene
Disorders for RANGAP1 Gene
Additional Disease Information for RANGAP1
No disorders were found for RANGAP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANGAP1 Gene
Publications for RANGAP1 Gene
- Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. (PMID: 7878053) Bischoff FR … Ponstingl H (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22 58
- Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. (PMID: 15931224) Reverter D … Lima CD (Nature 2005) 3 4 22 58
- RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. (PMID: 15037602) Swaminathan S … Melchior F (The Journal of cell biology 2004) 3 4 22 58
- Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1. (PMID: 8973340) Krebber H … Ponstingl H (Gene 1996) 3 4 22 58
- Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. (PMID: 19285941) Zhu S … Matunis MJ (Molecular cell 2009) 3 22 58
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Sources for RANGAP1 Gene
- (1) GeneCards
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