Aliases for RANGAP1 Gene
Aliases for RANGAP1 Gene
External Ids for RANGAP1 Gene
- HGNC: 9854
- Entrez Gene: 5905
- Ensembl: ENSG00000100401
- OMIM: 602362
- UniProtKB: P46060
Previous HGNC Symbols for RANGAP1 Gene
- SD
Previous GeneCards Identifiers for RANGAP1 Gene
- GC22M038256
- GC22M039884
- GC22M039966
- GC22M041641
- GC22M024606
Summaries for RANGAP1 Gene
-
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for RANGAP1 Gene
RANGAP1 (Ran GTPase Activating Protein 1) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity.
UniProtKB/Swiss-Prot for RANGAP1 Gene
-
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANGAP1 Gene
Genomics for RANGAP1 Gene
Regulatory Elements for RANGAP1 Gene
Enhancers for RANGAP1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around RANGAP1 on UCSC Golden Path with GeneCards custom track
Promoters for RANGAP1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around RANGAP1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the RANGAP1 gene promoter:
Regulatory Element Products
Genomic Location for RANGAP1 Gene
- Chromosome:
- 22
- Start:
- 41,244,777 bp from pter
- End:
- 41,302,210 bp from pter
- Size:
- 57,434 bases
- Orientation:
- Minus strand
Genomic View for RANGAP1 Gene
Genes around RANGAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.2 by Ensembl
- 22q13 by Entrez Gene
- 22q13 by HGNC
RANGAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RANGAP1 Gene
Proteins for RANGAP1 Gene
-
Protein details for RANGAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46060-RAGP1_HUMAN
- Recommended name:
- Ran GTPase-activating protein 1
- Protein Accession:
- P46060
- Q96JJ2
Protein attributes for RANGAP1 Gene
- Size:
- 587 amino acids
- Molecular mass:
- 63542 Da
- Quaternary structure:
-
- Homodimer. Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the ubiquitin-conjugating enzyme E2. Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and subsequently stabilizes interactions of sumoylated RANGAP1 with RANBP2/NUP358. The SUMO1/RANGAP1/UBC9/NUP358 complex associates with nuclear pore complexes. Interacts with TRAF6.
- SequenceCaution:
-
- Sequence=BAB47464.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for RANGAP1 Gene
Post-translational modifications for RANGAP1 Gene
- Phosphorylated occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBC9, on nuclear pore complex (NPC) diassembly and during mitosis.
- Sumoylated with SUMO1. Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis. Also required for interaction with RANBP2 and is mediated by UBC9.
- Ubiquitination at Lys 296 and Lys 452
- Modification sites at PhosphoSitePlus
Other Protein References for RANGAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RANGAP1 (RanGAP1)
- Cell Signaling Technology (CST) Antibodies for RANGAP1 (RANGAP1)
- Novus Biologicals Antibodies for RANGAP1
- Invitrogen Antibodies for RANGAP1
- antibodies-online Antibodies for RANGAP1: See all 85
- GeneTex RANGAP1 antibody for RANGAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RANGAP1
Protein Products
-
OriGene Purified Proteins for RANGAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for RANGAP1
- Origene Custom Protein Services for RANGAP1
- antibodies-online Proteins for RANGAP1: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for RANGAP1
Assay Products
- antibodies-online Kits for RANGAP1: See all 2
No data available for DME Specific Peptides for RANGAP1 Gene
Domains & Families for RANGAP1 Gene
Protein Domains for RANGAP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RANGAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P46060UniProtKB/Swiss-Prot:
RAGP1_HUMAN :- Belongs to the RNA1 family.
- Contains 6 LRR (leucine-rich) repeats.
- Family:
-
- Belongs to the RNA1 family.
- Similarity:
-
- Contains 6 LRR (leucine-rich) repeats.
No data available for Gene Families for RANGAP1 Gene
Function for RANGAP1 Gene
Molecular function for RANGAP1 Gene
- GENATLAS Biochemistry:
- Ran GTPase activating protein 1,homolog of yeast Rna1p,component of the nuclear pore complex,highly concentrated at its cytoplasmic periphery,conjugating with UBL1 in a ATP dependent fashion,then associating with RANBP2. Involved in mRNA processing and transport
- UniProtKB/Swiss-Prot Function:
- GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IEA | -- |
Phenotypes for RANGAP1 Gene
- MGI mutant phenotypes for RANGAP1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RANGAP1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for RANGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
- Search ViGene Biosciences for RANGAP1
CRISPR Products
-
OriGene CRISPR knockouts for RANGAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
- GenScript: Design CRISPR guide RNA sequences for RANGAP1
miRNA for RANGAP1 Gene
- miRTarBase miRNAs that target RANGAP1
-
- hsa-mir-16-5p (MIRT031630)
- hsa-mir-1301-3p (MIRT036035)
- hsa-mir-331-3p (MIRT043425)
- hsa-mir-92a-3p (MIRT049661)
- hsa-mir-31-5p (MIRT049887)
- hsa-mir-4730 (MIRT453756)
- hsa-mir-7847-3p (MIRT453757)
- hsa-mir-6851-5p (MIRT453758)
- hsa-mir-6880-5p (MIRT453759)
- hsa-mir-3689d (MIRT453760)
- hsa-mir-7854-3p (MIRT453761)
- hsa-mir-3934-5p (MIRT453762)
- hsa-mir-764 (MIRT453763)
- hsa-mir-125a-3p (MIRT453764)
- hsa-mir-5197-5p (MIRT453765)
- hsa-mir-6749-3p (MIRT612590)
- hsa-mir-4707-3p (MIRT612591)
- hsa-mir-18a-3p (MIRT612592)
- hsa-mir-324-3p (MIRT612593)
- hsa-mir-1913 (MIRT612594)
- hsa-mir-150-5p (MIRT612595)
- hsa-mir-186-3p (MIRT612596)
- hsa-mir-520h (MIRT612597)
- hsa-mir-520g-3p (MIRT612598)
- hsa-mir-520e (MIRT612599)
- hsa-mir-520d-3p (MIRT612600)
- hsa-mir-520c-3p (MIRT612601)
- hsa-mir-520b (MIRT612602)
- hsa-mir-520a-3p (MIRT612603)
- hsa-mir-373-3p (MIRT612604)
- hsa-mir-372-3p (MIRT612605)
- hsa-mir-302e (MIRT612606)
- hsa-mir-302d-3p (MIRT612607)
- hsa-mir-302c-3p (MIRT612608)
- hsa-mir-302b-3p (MIRT612609)
- hsa-mir-302a-3p (MIRT612610)
- hsa-mir-93-5p (MIRT612611)
- hsa-mir-526b-3p (MIRT612612)
- hsa-mir-519d-3p (MIRT612613)
- hsa-mir-20b-5p (MIRT612614)
- hsa-mir-20a-5p (MIRT612615)
- hsa-mir-17-5p (MIRT612616)
- hsa-mir-106b-5p (MIRT612617)
- hsa-mir-106a-5p (MIRT612618)
- hsa-mir-129-5p (MIRT625442)
- hsa-mir-8055 (MIRT625443)
- hsa-mir-6864-3p (MIRT625444)
- hsa-mir-3672 (MIRT625445)
- hsa-mir-4753-3p (MIRT625446)
- hsa-mir-6873-3p (MIRT625447)
- hsa-mir-155-3p (MIRT625448)
- hsa-mir-223-3p (MIRT625449)
- hsa-mir-4697-3p (MIRT625450)
- hsa-mir-4524a-3p (MIRT625451)
- hsa-mir-130b-5p (MIRT625452)
- hsa-mir-6817-3p (MIRT625453)
- hsa-mir-7110-3p (MIRT625454)
- hsa-mir-1182 (MIRT625455)
- hsa-mir-4524b-3p (MIRT625456)
- hsa-mir-6796-3p (MIRT625457)
- hsa-mir-3159 (MIRT625458)
- hsa-mir-7151-3p (MIRT630565)
- hsa-mir-5095 (MIRT630566)
- hsa-mir-4438 (MIRT630567)
- hsa-mir-3149 (MIRT639235)
- hsa-mir-197-3p (MIRT639236)
- hsa-mir-4711-5p (MIRT639237)
- hsa-mir-7112-3p (MIRT639238)
- hsa-mir-4267 (MIRT639239)
- hsa-mir-153-5p (MIRT639240)
- hsa-mir-1250-3p (MIRT639241)
- hsa-mir-500b-3p (MIRT639242)
- hsa-mir-3124-3p (MIRT709232)
- hsa-mir-1238-3p (MIRT709233)
- hsa-mir-670-3p (MIRT709234)
- hsa-mir-452-3p (MIRT709235)
- hsa-mir-627-3p (MIRT709236)
- hsa-mir-483-3p (MIRT709237)
- hsa-mir-664a-3p (MIRT709238)
- hsa-mir-3142 (MIRT709239)
- hsa-mir-1245b-5p (MIRT709240)
- hsa-mir-32-3p (MIRT709241)
- hsa-mir-4753-5p (MIRT709242)
miRNA Products
- Search ViGene Biosciences for RANGAP1
Clone Products
- OriGene clones in human for RANGAP1
- OriGene ORF clones in human,mouse,rat for RANGAP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RANGAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RANGAP1
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for RANGAP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RANGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANGAP1 Gene
Localization for RANGAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RANGAP1 Gene
- Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 5 |
| cytoskeleton | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | colocalizes_with kinetochore | IDA | 17363900 |
| GO:0005635 | nuclear envelope | TAS | -- |
| GO:0005643 | nuclear pore | IEA,TAS | 8978815 |
| GO:0005737 | cytoplasm | IDA | -- |
| GO:0030425 | dendrite | IEA | -- |
Pathways & Interactions for RANGAP1 Gene
More details on SuperPathways for RANGAP1| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Infectious disease |
.64
|
.48
|
| 2 | Cell Cycle, Mitotic |
.83
|
.61
|
| 3 | Regulation of Glucokinase by Glucokinase Regulatory Protein | ||
| 4 | Mitotic Metaphase and Anaphase |
.94
|
|
| 5 | Mitotic Prometaphase |
Pathways by source for RANGAP1 Gene
3 BioSystems pathways for RANGAP1 Gene
25 Reactome pathways for RANGAP1 Gene
1 KEGG pathway for RANGAP1 Gene
1 GeneGo (Thomson Reuters) pathway for RANGAP1 Gene
2 Qiagen pathways for RANGAP1 Gene
Interacting Proteins for RANGAP1 Gene
Selected Interacting proteins:
P46060-RAGP1_HUMAN
ENSP00000348577
for RANGAP1 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007062 | sister chromatid cohesion | TAS | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0048678 | response to axon injury | IEA | -- |
Transcripts for RANGAP1 Gene
mRNA/cDNA for RANGAP1 Gene
- (11) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (323) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RANGAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RANGAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
- GenScript: Design CRISPR guide RNA sequences for RANGAP1
miRNA Products
- Search ViGene Biosciences for RANGAP1
Clone Products
- OriGene clones in human for RANGAP1
- OriGene ORF clones in human,mouse,rat for RANGAP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RANGAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RANGAP1
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - | - | |||||||||
| SP3: | - | - | |||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: |
Expression for RANGAP1 Gene
This gene is overexpressed in Bone (14.4), Nasal epithelium (8.0), and Lymph node (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANGAP1 Gene
SOURCE GeneReport for Unigene cluster for RANGAP1 Gene Hs.183800
mRNA Expression by UniProt/SwissProt for RANGAP1 Gene
P46060-RAGP1_HUMAN
Tissue specificity:
Highly expressed in brain, thymus and testis.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for RANGAP1
-
OriGene qPCR primer pairs and template standards for RANGAP1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RANGAP1 Gene
Orthologs for RANGAP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | RANGAP1 35 |
|
||
| RANGAP1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | RANGAP1 35 |
|
||
| RANGAP1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Rangap1 35 |
|
||
| Rangap1 16 |
|
||||
| Rangap1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | RANGAP1 35 |
|
||
| RANGAP1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Rangap1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RANGAP1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RANGAP1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RANGAP1 35 |
|
||
| RANGAP1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | RANGAP1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rangap1 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | rangap1-prov 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.26558 35 |
|
||
| rangap1a 35 |
|
||||
| rangap1a 36 |
|
OneToMany | |||
| rangap1b 36 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1664 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | RanGap 36 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | ran-2 37 |
|
|
|
| ran-2 36 |
|
OneToOne | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR525C 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F25036g 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RNA1 35 |
|
||
| RNA1 36 |
|
OneToOne | |||
| RNA1 38 |
|
|
|||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03207 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rna1 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9560 36 |
|
OneToOne |
- Species with no ortholog for RANGAP1:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RANGAP1 Gene
No data available for Paralogs for RANGAP1 Gene
Variants for RANGAP1 Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2229752 | - | 41,264,747(-) | GCTTC(A/C/G)AGGCC | reference, missense | |
| rs1953 | -- | 41,245,980(+) | CCACA(C/T)GGTGT | utr-variant-3-prime | |
| rs60171 | -- | 41,278,517(-) | aacac(C/T)gtgtc | intron-variant | |
| rs71948 | -- | 41,249,753(+) | ACGAG(C/G)AGCCT | reference, synonymous-codon | |
| rs2179745 | -- | 41,287,084(+) | taata(G/T)tattg | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv524585 | CNV | Loss | 19592680 |
| nsv915116 | CNV | Loss | 21882294 |
| nsv915117 | CNV | Loss | 21882294 |
| nsv915118 | CNV | Loss | 21882294 |
| nsv915119 | CNV | Loss | 21882294 |
| nsv459888 | CNV | Gain | 19166990 |
| nsv817997 | CNV | Gain | 17921354 |
| nsv516925 | CNV | Loss | 19592680 |
| nsv3637 | CNV | Loss | 18451855 |
| nsv915120 | CNV | Loss | 21882294 |
| nsv834207 | CNV | Loss | 17160897 |
| nsv3638 | CNV | Insertion | 18451855 |
Residual Variation Intolerance Score:
27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.35;
41.77% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RANGAP1 Gene
- Human Gene Mutation Database (HGMD)
- RANGAP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANGAP1 Gene
Disorders for RANGAP1 Gene
Relevant External Links for RANGAP1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- RANGAP1
No disorders were found for RANGAP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANGAP1 Gene
Publications for RANGAP1 Gene
- Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. (PMID: 7878053) Bischoff F.R. … Ponstingl H. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23 67
- Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. (PMID: 19285941) Zhu S. … Matunis M.J. (Mol. Cell 2009) 3 23
- The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import. (PMID: 18305100) Hutten S. … Kehlenbach R.H. (Mol. Biol. Cell 2008) 3 23
- Mel-18 interacts with RanGAP1 and inhibits its sumoylation. (PMID: 18706886) Zhang J. … Sarge K.D. (Biochem. Biophys. Res. Commun. 2008) 3 23
- Chip-based analysis of SUMO (small ubiquitin-like modifier) conjugation to a target protein. (PMID: 16820290) Oh Y.H. … Kim H.S. (Biosens Bioelectron 2007) 3 23
Products for RANGAP1 Gene
- R&D Systems Antibodies for RANGAP1 (RanGAP1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RANGAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for RANGAP1
- Origene Custom Protein Services for RANGAP1
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for RANGAP1
- Browse OriGene Inhibitory RNA Products For RANGAP1
- OriGene qPCR primer pairs for RANGAP1
- OriGene qPCR primer pairs and template standards for RANGAP1
- OriGene CRISPR knockouts for RANGAP1
- OriGene clones in human for RANGAP1
- OriGene ORF clones in human,mouse,rat for RANGAP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for RANGAP1
- GenScript Custom Assay Services for RANGAP1
- GenScript Custom overexpressing Cell Line Services for RANGAP1
- GenScript: Design CRISPR guide RNA sequences for RANGAP1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for RANGAP1
- Cell Signaling Technology (CST) Antibodies for RANGAP1 (RANGAP1)
- Search for Antibodies & Assays
- Novus Biologicals Antibodies for RANGAP1
- Novus Biologicals proteins and lysates for RANGAP1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Addgene plasmids for RANGAP1
- antibodies-online Antibodies for RANGAP1: See all 85
- antibodies-online Kits for RANGAP1: See all 2
- antibodies-online Proteins for RANGAP1: See all 6
- Search antibodies-online for peptides
- GeneTex RANGAP1 antibody for RANGAP1
- Search GeneTex for Proteins for RANGAP1
- ViGene Biosciences adenoviral particle packaged cDNA for RANGAP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RANGAP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RANGAP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RANGAP1 gene
- Search ViGene Biosciences for RANGAP1
- Search ViGene Biosciences for RANGAP1
- Santa Cruz Biotechnology (SCBT) Antibodies for RANGAP1
- Search Santa Cruz Biotechnology (SCBT) for RANGAP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
Sources for RANGAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon