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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RANGAP1 Gene

protein-coding GIFtS: 65
GCID: GC22M041641

Ran GTPase activating protein 1

(Previous name: segregation distorter homolog (Drosophila) )
(Previous symbol: SD)

Explore 1 disease affiliated with
RANGAP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ran GTPase Activating Protein 1¹ ²		Ran GTPase-Activating Protein 1²
SD¹ ² ³		Segregation Distorter Homolog²
Fug1¹ ²		Segregation Distortion²
KIAA1835¹ ³		RanGAP1³
Segregation Distorter Homolog (Drosophila)¹

External Ids:	HGNC: 9854¹	Entrez Gene: 5905²	Ensembl: ENSG00000100401⁷	OMIM: 602362⁵	UniProtKB: P46060³

Export aliases for RANGAP1 gene to outside databases

Previous GC identifers: GC22M038256 GC22M039884 GC22M039966 GC22M024606

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RANGAP1:

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by

over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active,

GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase

activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1

and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN

GTP/GDP cycle. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RAGP1_HUMAN, P46060

Function: GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive

GDP-bound state

Gene Wiki entry for RANGAP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RANGAP1 gene promoter:
AhR CREB p53 AP-1 deltaCREB ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RANGAP1 promoter sequence

Search SABiosciences Chromatin IP Primers for RANGAP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RANGAP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13

RANGAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RANGAP1 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M041641: view genomic region (about GC identifiers)

Start:	41,641,615 bp from pter	End:	41,698,963 bp from pter
Size:	57,349 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAGP1_HUMAN, P46060 (See protein sequence)

Recommended Name: Ran GTPase-activating protein 1

Size: 587 amino acids; 63542 Da

Subunit: Homodimer. Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the ubiquitin-conjugating

enzyme E2. Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and subsequently stabilizes interactions

of sumoylated RANGAP1 with RANBP2/NUP358. The SUMO1/RANGAP1/UBC9/NUP358 complex associates with nuclear pore

complexes. Interacts with TRAF6

Subcellular location: Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome,

centromere, kinetochore (By similarity). Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=Cytoplasmic

during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles.

Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic

location also requires sumoylation

Sequence caution: Sequence=BAB47464.1; Type=Erroneous initiation;

6/12 PDB 3D structures from and Proteopedia for RANGAP1 (see all 12):

1Z5S (3D)

2GRN (3D)

2GRO (3D)

2GRP (3D)

2GRQ (3D)

2GRR (3D)

Secondary accessions: Q96JJ2

Explore the universe of human proteins at neXtProt for RANGAP1: NX_P46060

Post-translational modifications:

Phosphorylated occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase

kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The

phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBC9, on nuclear pore

complex (NPC) diassembly and during mitosis¹

Sumoylated with SUMO1. Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with

mitotic spindles and kinetochores during mitosis. Also required for interaction with RANBP2 and is mediated by UBC9¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P46060

RANGAP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002874.1

ENSEMBL proteins:

ENSP00000385866 ENSP00000348577 ENSP00000385086 ENSP00000401470 ENSP00000393407

ENSP00000394787 ENSP00000408743 ENSP00000404842 ENSP00000385354

Reactome Protein details: P46060
Human Recombinant Protein Products for RANGAP1:

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	Uscn Proteins for RANGAP1

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000776	colocalizes with kinetochore	IDA	17363900
GO:0000777	condensed chromosome kinetochore	IEA	--
GO:0000922	spindle pole	IEA	--
GO:0005625	soluble fraction	--	--
GO:0005643	nuclear pore	TAS	8978815

RANGAP1 for ontologies About GeneDecksing

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	ThermoFisher Antibodies for RANGAP1

Assay Products for RANGAP1:

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	Uscn ELISAs and CLIAs for RANGAP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RANGAP1 for domains About GeneDecksing

2 InterPro domains/families:

IPR027038 RanGap

IPR009109 Ran_GTPase_activating_1_C

Graphical View of Domain Structure for InterPro Entry P46060

ProtoNet protein and cluster: P46060

1 Blocks protein family: IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: RAGP1_HUMAN, P46060

Similarity: Belongs to the RNA1 family

Similarity: Contains 6 LRR (leucine-rich) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RAGP1_HUMAN, P46060

Function: GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive

GDP-bound state

Genatlas biochemistry entry for RANGAP1:

Ran GTPase activating protein 1,homolog of yeast Rna1p,component of the nuclear pore complex,highly concentrated at its

cytoplasmic periphery,conjugating with UBL1 in a ATP dependent fashion,then associating with RANBP2. Involved in mRNA

processing and transport

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005098	Ran GTPase activator activity	IEA	--
GO:0005515	protein binding	IPI	17000644

RANGAP1 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rangap1):

embryogenesis

growth/size

mortality/aging

RANGAP1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RANGAP1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANGAP1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Proteolysis Putative SUMO-1 pathway

Proteolysis Putative SUMO-1 pathway

1.00

Proteolysis_Putative SUMO-1 pathway

0.97

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Ran Pathway

Ran Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RANGAP1

Proteolysis Putative SUMO-1 pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RANGAP1

	Ran Pathway
	SUMO Pathway

1 GeneGo (Thomson Reuters) Pathway for RANGAP1

Proteolysis Putative SUMO-1 pathway

3 BioSystems Pathways for RANGAP1

	Signaling events mediated by HDAC Class II
	Sumoylation by RanBP2 regulates transcriptional repression
	Signaling events mediated by HDAC Class I

5/10 Reactome Pathways for RANGAP1 (see all 10)

	Mitotic Metaphase and Anaphase
	Mitotic Prometaphase
	Resolution of Sister Chromatid Cohesion
	Mitotic Anaphase
	Cell Cycle

1 Kegg Pathway (Kegg details for RANGAP1):

RNA transport

RANGAP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RANGAP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/866 Interacting proteins for RANGAP1 (P46060^{1, 2, 3} ENSP00000348577⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 866)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GCN1L1	Q92616²^,³, ENSP00000300648⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000300648
HIRA	P54198²^,³, ENSP00000263208⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000263208
UBE2I	P63279²^,³, ENSP00000324897⁴	MINT-3380689 I2D: score=6 STRING: ENSP00000324897
BABAM1	Q9NWV8²^,³, ENSP00000352408⁴	MINT-7945693 I2D: score=2 STRING: ENSP00000352408
EEF1A1	P68104²^,³	MINT-7945693 MINT-7947479 I2D: score=2

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000236	mitotic prometaphase	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0007165	signal transduction	IEA	--
GO:0032853	positive regulation of Ran GTPase activity	TAS	7878053

RANGAP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RANGAP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RANGAP1
2 Novoseek chemical compound relationships for RANGAP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	63.9	12	10473610 (2), 7744835 (1), 10322113 (1), 8146159 (1) (see all 8)
lysine	24.3	1	9442102 (1)

Search CenterWatch for drugs/clinical trials and news about RANGAP1 / RAGP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RANGAP1 gene:

NM_002883.2

Unigene Cluster for RANGAP1:

Ran GTPase activating protein 1

Hs.183800 [show with all ESTs]

Unigene Representative Sequence: BC041396

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000405486(uc003azt.3) ENST00000356244(uc011aoz.2 uc003azu.3)

ENST00000405383 ENST00000455915(uc003azs.3) ENST00000493783 ENST00000446258

ENST00000452543 ENST00000418067 ENST00000422838 ENST00000407260

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Additional cDNA sequence:

AK302222.1 AK303524.1 BC004990.1 BC014044.2 BC019676.1 BC041396.2 BC048990.1 CR456557.1

X82260.1

24/36 DOTS entries (see all 36):

DT.100647773 DT.449648 DT.95154111 DT.100852871 DT.100647772 DT.100645443 DT.92451019 DT.100647777

DT.100709463 DT.100711353 DT.100768599 DT.92451021 DT.95272271 DT.100647775 DT.100839566 DT.100859349

DT.75170405 DT.100038346 DT.100637492 DT.100854577 DT.100864211 DT.92451015 DT.95272269 DT.100800164

24/323 AceView cDNA sequences (see all 323):

BU172653 BM559416 BQ000147 BM553409 H55068 CD722788 BM550690 BC004990

BM911800 CR595421 BU681186 BM810912 BQ061240 BQ217588 CR599804 BC012882

BM694126 BU182483 BU194287 CR456557 BM553423 BU172655 AA709404 BE729240

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RANGAP1 (see all 12) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	·	8c	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^
SP1:													-		-		-		-		-		-		-
SP2:
SP3:																																																			-
SP4:													-		-				-		-		-		-
SP5:													-		-				-				-		-

ExUns:	15a	·	15b	^	16a	·	16b	^	17a	·	17b
SP1:
SP2:	-						-
SP3:	-						-
SP4:
SP5:

ECgene alternative splicing isoforms for RANGAP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RANGAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCCCCTT

About this image

RANGAP1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RANGAP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RANGAP1

SOURCE GeneReport for Unigene cluster: Hs.183800

UniProtKB/Swiss-Prot: RAGP1_HUMAN, P46060

Tissue specificity: Highly expressed in brain, thymus and testis

SABiosciences Expression via Pathway-Focused PCR Array including RANGAP1:

Multiple Sclerosis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANGAP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANGAP1 gene from 10/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rangap1^{1 , 5}	RAN GTPase activating protein 1^{1, 5}	86.09(n)¹ 89.1(a)¹		15 (38.21 cM)⁵ 19387¹ NM_001146174.1¹ NP_001139646.1¹ 81704248⁵
chicken (Gallus gallus)	Aves	RANGAP1¹	Ran GTPase activating protein 1	75.46(n) 82.24(a)		417997 NM_001006237.1 NP_001006237.1
lizard (Anolis carolinensis)	Reptilia	RANGAP1⁶	--	77(a)	1 ↔ 1	5(26276662-26293320)
African clawed frog (Xenopus laevis)	Amphibia	rangap1-prov²	RAN GTPase activating protein 1	75.33(n)		BC043982.1
zebrafish (Danio rerio)	Actinopterygii	Dr.26558²	Danio rerio cDNA clone MGC66165 IMAGE5600717, complete more	73.92(n)		BC054654.1
fruit fly (Drosophila melanogaster)	Insecta	RanGap¹	Ran GTPase activating protein	53.65(n) 42.29(a)		35223 NM_057364.3 NP_476712.1
worm (Caenorhabditis elegans)	Secernentea	ran-2³	RNA production/processing	51(a)		--
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RNA1(YMR235C)⁴ RNA1¹	GTPase activating protein (GAP) for Gsp1p, involved more⁴ Rna1p¹	45.65(n)¹ 33.61(a)¹		13(742735-741512)⁴ 855275^{1, 4} NP_013962.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G06000⁶ ATRANGAP1⁶ (see all 3)	RAN GTPase-activating protein 1 (see all 3)	24(a) 20(a) (see all 3)	many → 1 many → 1 (see all 3)	3(1801446-1802081) 3(23324609-23326973)
rice (Oryza sativa)	Liliopsida	-- --	ran GTPase activating protein, putative RAN GTPase-activating protein 1, putative, express...	25(a) 19(a)	many → 1 many → 1	5(19918983-19919933) 5(26895864-26898860)

ENSEMBL Gene Tree for RANGAP1 (if available)
TreeFam Gene Tree for RANGAP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6002296^1,2		--	41641170(+)	`ACCTAC/TGTGGC`	1	--	ds500¹		0	--	--	--	--
rs9637339^1,2	H	--	41641282(+)	`GGGTAG/AGAGGT`	1	--	ds500¹		4		NS EA	420
rs117983667^1,2		--	41641311(+)	`TGTCCT/GCACAT`	1	--	ds500¹		1		NA	120
rs6002298^1,2	C,F,H	--	41641570(+)	`TACAAC/TGGCCC`	1	--	ds500¹		25		NS EA NA WA CSA	2552
rs183174209^1,2		--	41641649(+)	`GCCCCC/TGGGCA`	1	--	ut3¹		0	--	--	--	--
rs146895453^1,2		--	41641672(+)	`ACACAC/GAGCAC`	1	--	ut3¹		0	--	--	--	--
rs187859921^1,2		--	41641703(+)	`GTCACA/GGGTGC`	1	--	ut3¹		0	--	--	--	--
rs11913689^1,2	H	--	41641751(+)	`TACCGC/GTCCCC`	1	--	ut3¹ ese³		0	--	--	--	--
rs57712473^1,2		--	41641784(+)	`GCAGCA/GTCCAG`	1	--	ut3¹		0	--	--	--	--
rs73885753^1,2	C,F	--	41641924(+)	`GGTCCG/AGGGCC`	1	--	ut3¹		3		WA	122

HapMap Linkage Disequilibrium report for RANGAP1 (41641615 - 41698963 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for RANGAP1
5 CNVs: 5188 50867 36032 9849 50866

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RANGAP1 for disorders           About GeneDecksing

OMIM gene information: 602362    OMIM disorders: --

1 disease for RANGAP1:    About MalaCards

herpes simplex

Export disorders for RANGAP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RANGAP1 gene, integrated from 9 sources (see all 117):
(articles sorted by number of sources associating them with RANGAP1)

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Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. (PubMed id 7878053)^{1, 2, 3, 9} Bischoff F.R.... Ponstingl H. (1995)
Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1. (PubMed id 8973340)^{1, 2, 9} Krebber H. and Ponstingl H. (1996)
Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9- Nup358 complex. (PubMed id 15931224)^{1, 2, 9} Reverter D. and Lima C.D. (2005)
Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. (PubMed id 18093978)^{1, 2} Pham L.V....Ford R.J. (2008)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. (PubMed id 11854305)^{1, 2} Joseph J.... Dasso M. (2002)
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2} Nagase T.... Ohara O. (2001)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5905	HGNC: 9854	AceView: RANGAP1	Ensembl:ENSG00000100401	euGenes: HUgn5905
ECgene: RANGAP1	Kegg: 5905	H-InvDB: RANGAP1

(According to HUGE)
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HUGE: KIAA1835

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RANGAP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RANGAP1 gene
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Patent Information for RANGAP1 gene:
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Ran GTPase activating protein 1

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Ran GTPase activating protein 1

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