RANGAP1 Gene

Aliases
for RANGAP1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC22M038256 GC22M039884 GC22M039966 GC22M024606

Summaries
for RANGAP1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for RANGAP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000022.10  NT_011520.13  NC_018933.2  

SwitchGear Promoter luciferase reporter plasmid: RANGAP1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RANGAP1

RANGAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M041641:  view genomic region     (about GC identifiers)

Proteins
for RANGAP1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Selected PDB 3D structures from and Proteopedia for RANGAP1 (see all 12):

1Z5S (3D)        2GRN (3D)        2GRO (3D)        2GRP (3D)        2GRQ (3D)        2GRR (3D)    

Explore the universe of human proteins at neXtProt for RANGAP1: NX_P46060

Explore proteomics data for RANGAP1 at MOPED

Post-translational modifications: 

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	antibodies-online peptides for RANGAP1

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Domains /
Families
for RANGAP1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P46060

Find genes that share domains with RANGAP1           About GenesLikeMe

Function
for RANGAP1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Rangap1)

genOway: Develop your customized and physiologically relevant rodent model for RANGAP1

miRNA Products:		miRTarBase miRNAs that target RANGAP1: hsa-mir-31-5p (MIRT049887), hsa-mir-92a-3p (MIRT049661), hsa-mir-1301-3p (MIRT036035), hsa-mir-331-3p (MIRT043425), hsa-mir-16-5p (MIRT031630)
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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANGAP1

Localization
for RANGAP1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytosol	4
cytoskeleton	2

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Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

Pathways & Interactions
for RANGAP1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for RANGAP1 About   (see all 13)   See pathways by source

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	SuperPath	Contained pathways About
1	HIV Life Cycle	HIV Life Cycle 0.91 HIV Infection 0.62 Late Phase of HIV Life Cycle 0.91 Host Interactions of HIV factors 0.60
2	Mitotic Metaphase and Anaphase	Separation of Sister Chromatids 0.94 Mitotic Metaphase and Anaphase 0.93 Mitotic Anaphase 0.94
3	Cell Cycle, Mitotic	Cell Cycle, Mitotic 0.90 M Phase 0.62 Cell Cycle 0.90
4	Mitotic Prometaphase	Mitotic Prometaphase 0.92 Resolution of Sister Chromatid Cohesion 0.92
5	Regulation of Glucokinase by Glucokinase Regulatory Protein	Rev-mediated nuclear export of HIV RNA 0.91 Interactions of Rev with host cellular proteins 0.91

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RANGAP1

	Ran Pathway
	SUMO Pathway

1 GeneGo (Thomson Reuters) Pathway for RANGAP1

Proteolysis Putative SUMO-1 pathway

3 BioSystems Pathways for RANGAP1

	Signaling events mediated by HDAC Class I
	Sumoylation by RanBP2 regulates transcriptional repression
	Signaling events mediated by HDAC Class II

4 Reactome Pathways for RANGAP1

	Rev-mediated nuclear export of HIV RNA
	Resolution of Sister Chromatid Cohesion
	Mitotic Prometaphase
	Separation of Sister Chromatids

1 Kegg Pathway  (Kegg details for RANGAP1)

RNA transport

Gene Ontology (GO): 4 biological process terms:    About this table

Drugs & Compounds
for RANGAP1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for RANGAP1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for RANGAP1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RANGAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTTTCCCCTT

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Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Ovary (Reproductive System)    fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct
Testis (Reproductive System)
Leydig Cells Testis Interstitium
Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Pancreas (Endocrine System)
Islets of Langerhans

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANGAP1

Orthologs
for RANGAP1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for RANGAP1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for RANGAP1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RANGAP1 (see all 932)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs60022961,2	C	--	41641170(+)	ACCTAC/TGTGGC	1	--	ds5001		0	--	--	--	--
rs96373391,2	H	--	41641282(+)	GGGTAG/AGAGGT	1	--	ds5001		4		NS EA	420
rs1179836671,2	C,F	--	41641311(+)	TGTCCT/GCACAT	1	--	ds5001		1		NA	120
rs60022981,2	C,F,H	--	41641570(+)	TACAAC/TGGCCC	1	--	ds5001		25		NS EA NA WA CSA	2552
rs1831742091,2		--	41641649(+)	GCCCCC/TGGGCA	1	--	ut31		0	--	--	--	--
rs1468954531,2		--	41641672(+)	ACACAC/GAGCAC	1	--	ut31		0	--	--	--	--
rs1878599211,2		--	41641703(+)	GTCACA/GGGTGC	1	--	ut31		0	--	--	--	--
rs119136891,2	H	--	41641751(+)	TACCGC/GTCCCC	1	--	ut31 ese3		0	--	--	--	--
rs577124731,2	C	--	41641784(+)	GCAGCA/GTCCAG	1	--	ut31		0	--	--	--	--
rs738857531,2	C,F	--	41641924(+)	GGTCCG/AGGGCC	1	--	ut31		3		WA	122

HapMap Linkage Disequilibrium report for RANGAP1 (41641615 - 41682255 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for RANGAP1 (see all 12):    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv3638	CNV	Insertion	18451855
nsv915118	CNV	Loss	21882294
nsv915117	CNV	Loss	21882294
nsv834207	CNV	Loss	17160897
nsv915119	CNV	Loss	21882294
nsv915120	CNV	Loss	21882294
nsv915116	CNV	Loss	21882294
nsv524585	CNV	Loss	19592680
nsv516925	CNV	Loss	19592680
nsv3637	CNV	Loss	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RANGAP1

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Disorders / Diseases
for RANGAP1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for RANGAP1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. (PubMed id 7878053)^{1, 2, 3, 9} Bischoff F.R.... Ponstingl H. (Proc. Natl. Acad. Sci. U.S.A. 1995)
2. Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1. (PubMed id 8973340)^{1, 2, 9} Krebber H. and Ponstingl H. (Gene 1996)
3. RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. (PubMed id 15037602)^{1, 2, 9} Swaminathan S....Melchior F. (J. Cell Biol. 2004)
4. Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9- Nup358 complex. (PubMed id 15931224)^{1, 2, 9} Reverter D. and Lima C.D. (Nature 2005)
5. Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. (PubMed id 18093978)^{1, 2} Pham L.V.... Ford R.J. (J. Biol. Chem. 2008)
6. SUMO protease SENP1 induces isomerization of the scissile peptide bond. (PubMed id 17099698)^{1, 2} Shen L.... Hay R.T. (Nat. Struct. Mol. Biol. 2006)
7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (Genome Biol. 2004)
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
10. SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. (PubMed id 11854305)^{1, 2} Joseph J.... Dasso M. (J. Cell Biol. 2002)

External Searches for RANGAP1 gene

Genome Databases showing RANGAP1 gene

Other Databases showing RANGAP1 gene

Specialized Databases showing RANGAP1 gene

Products
for RANGAP1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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