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Aliases for RANGAP1 Gene

Aliases for RANGAP1 Gene

  • Ran GTPase Activating Protein 1 2 3
  • SD 3 4
  • Segregation Distorter Homolog (Drosophila) 2
  • Segregation Distorter Homolog 3
  • Segregation Distortion 3
  • KIAA1835 4
  • RanGAP1 4
  • RANGAP 3
  • Fug1 3

External Ids for RANGAP1 Gene

Previous HGNC Symbols for RANGAP1 Gene

  • SD

Previous GeneCards Identifiers for RANGAP1 Gene

  • GC22M038256
  • GC22M039884
  • GC22M039966
  • GC22M041641
  • GC22M024606

Summaries for RANGAP1 Gene

Entrez Gene Summary for RANGAP1 Gene

  • This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for RANGAP1 Gene

RANGAP1 (Ran GTPase Activating Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include GTPase activator activity.

UniProtKB/Swiss-Prot for RANGAP1 Gene

  • GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state

Gene Wiki entry for RANGAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANGAP1 Gene

Genomics for RANGAP1 Gene

Regulatory Elements for RANGAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RANGAP1 Gene

Chromosome:
22
Start:
41,244,777 bp from pter
End:
41,302,210 bp from pter
Size:
57,434 bases
Orientation:
Minus strand

Genomic View for RANGAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RANGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANGAP1 Gene

Proteins for RANGAP1 Gene

  • Protein details for RANGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46060-RAGP1_HUMAN
    Recommended name:
    Ran GTPase-activating protein 1
    Protein Accession:
    P46060
    Secondary Accessions:
    • Q96JJ2

    Protein attributes for RANGAP1 Gene

    Size:
    587 amino acids
    Molecular mass:
    63542 Da
    Quaternary structure:
    • Homodimer. Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the ubiquitin-conjugating enzyme E2. Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and subsequently stabilizes interactions of sumoylated RANGAP1 with RANBP2/NUP358. The SUMO1/RANGAP1/UBC9/NUP358 complex associates with nuclear pore complexes. Interacts with TRAF6.
    SequenceCaution:
    • Sequence=BAB47464.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RANGAP1 Gene

neXtProt entry for RANGAP1 Gene

Proteomics data for RANGAP1 Gene at MOPED

Post-translational modifications for RANGAP1 Gene

  • Phosphorylated occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBC9, on nuclear pore complex (NPC) diassembly and during mitosis.
  • Sumoylated with SUMO1. Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis. Also required for interaction with RANBP2 and is mediated by UBC9.
  • Ubiquitination at Lys 296 and Lys 452
  • Modification sites at PhosphoSitePlus

Other Protein References for RANGAP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RANGAP1 (RanGAP1)

No data available for DME Specific Peptides for RANGAP1 Gene

Domains & Families for RANGAP1 Gene

Protein Domains for RANGAP1 Gene

Suggested Antigen Peptide Sequences for RANGAP1 Gene

Graphical View of Domain Structure for InterPro Entry

P46060

UniProtKB/Swiss-Prot:

RAGP1_HUMAN :
  • Belongs to the RNA1 family.
  • Contains 6 LRR (leucine-rich) repeats.
Family:
  • Belongs to the RNA1 family.
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with RANGAP1: view

No data available for Gene Families for RANGAP1 Gene

Function for RANGAP1 Gene

Molecular function for RANGAP1 Gene

GENATLAS Biochemistry:
Ran GTPase activating protein 1,homolog of yeast Rna1p,component of the nuclear pore complex,highly concentrated at its cytoplasmic periphery,conjugating with UBL1 in a ATP dependent fashion,then associating with RANBP2. Involved in mRNA processing and transport
UniProtKB/Swiss-Prot Function:
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state

Gene Ontology (GO) - Molecular Function for RANGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 17000644
GO:0008536 Ran GTPase binding IEA --
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with RANGAP1: view

Phenotypes for RANGAP1 Gene

genes like me logo Genes that share phenotypes with RANGAP1: view

Animal Model Products

miRNA for RANGAP1 Gene

miRTarBase miRNAs that target RANGAP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RANGAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RANGAP1 Gene

Localization for RANGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANGAP1 Gene

Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RANGAP1 Gene COMPARTMENTS Subcellular localization image for RANGAP1 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for RANGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 colocalizes_with kinetochore IDA 17363900
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IEA --
GO:0005634 nucleus --
GO:0005643 nuclear pore TAS 8978815
genes like me logo Genes that share ontologies with RANGAP1: view

Pathways & Interactions for RANGAP1 Gene

genes like me logo Genes that share pathways with RANGAP1: view

Pathways by source for RANGAP1 Gene

1 KEGG pathway for RANGAP1 Gene
1 GeneGo (Thomson Reuters) pathway for RANGAP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Multiple Sclerosis in human,mouse,rat

SIGNOR curated interactions for RANGAP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RANGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007165 signal transduction TAS 7878053
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity TAS 7878053
GO:0046826 negative regulation of protein export from nucleus IDA 16449645
genes like me logo Genes that share ontologies with RANGAP1: view

Drugs & Compounds for RANGAP1 Gene

(1) Drugs for RANGAP1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lysine Nutra 70

(1) Additional Compounds for RANGAP1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
gtp
Partial agonist, Agonist
genes like me logo Genes that share compounds with RANGAP1: view

Transcripts for RANGAP1 Gene

Unigene Clusters for RANGAP1 Gene

Ran GTPase activating protein 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RANGAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANGAP1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - - - - - - -
SP2:
SP3: -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - -
SP9:
SP10: - -
SP11:
SP12:

ExUns: 15a · 15b ^ 16a · 16b ^ 17a · 17b
SP1:
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RANGAP1 Gene

GeneLoc Exon Structure for
RANGAP1
ECgene alternative splicing isoforms for
RANGAP1

Expression for RANGAP1 Gene

mRNA expression in normal human tissues for RANGAP1 Gene

Protein differential expression in normal tissues from HIPED for RANGAP1 Gene

This gene is overexpressed in Bone (14.4), Nasal epithelium (8.0), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANGAP1 Gene



SOURCE GeneReport for Unigene cluster for RANGAP1 Gene Hs.183800

mRNA Expression by UniProt/SwissProt for RANGAP1 Gene

P46060-RAGP1_HUMAN
Tissue specificity: Highly expressed in brain, thymus and testis.
genes like me logo Genes that share expression patterns with RANGAP1: view

Protein tissue co-expression partners for RANGAP1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RANGAP1 Gene

Orthologs for RANGAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RANGAP1 35
  • 87.69 (n)
  • 90.43 (a)
RANGAP1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RANGAP1 35
  • 89.72 (n)
  • 93.19 (a)
RANGAP1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rangap1 35
  • 86.09 (n)
  • 89.1 (a)
Rangap1 16
Rangap1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RANGAP1 35
  • 98.69 (n)
  • 98.64 (a)
RANGAP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rangap1 35
  • 86.18 (n)
  • 89.59 (a)
oppossum
(Monodelphis domestica)
Mammalia RANGAP1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RANGAP1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves RANGAP1 35
  • 75.46 (n)
  • 82.07 (a)
RANGAP1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RANGAP1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rangap1 35
  • 68.39 (n)
  • 70.29 (a)
African clawed frog
(Xenopus laevis)
Amphibia rangap1-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26558 35
rangap1a 35
  • 63.95 (n)
  • 61.06 (a)
rangap1a 36
  • 61 (a)
OneToMany
rangap1b 36
  • 57 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1664 35
fruit fly
(Drosophila melanogaster)
Insecta RanGap 36
  • 7 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ran-2 37
  • 51 (a)
ran-2 36
  • 12 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR525C 35
  • 47.05 (n)
  • 34.81 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25036g 35
  • 42.81 (n)
  • 33.66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNA1 35
  • 44.23 (n)
  • 32.36 (a)
RNA1 36
  • 5 (a)
OneToOne
RNA1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU03207 35
  • 49.64 (n)
  • 39.25 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rna1 35
  • 45.43 (n)
  • 38.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9560 36
  • 50 (a)
OneToOne
Species with no ortholog for RANGAP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RANGAP1 Gene

ENSEMBL:
Gene Tree for RANGAP1 (if available)
TreeFam:
Gene Tree for RANGAP1 (if available)

Paralogs for RANGAP1 Gene

No data available for Paralogs for RANGAP1 Gene

Variants for RANGAP1 Gene

Sequence variations from dbSNP and Humsavar for RANGAP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1953 -- 41,245,980(+) CCACA(C/T)GGTGT utr-variant-3-prime
rs60171 -- 41,278,517(-) aacac(C/T)gtgtc intron-variant
rs71948 -- 41,249,753(+) ACGAG(C/G)AGCCT synonymous-codon, reference
rs139498 -- 41,248,230(+) CATGA(C/G)ATTCA intron-variant
rs139499 -- 41,249,081(+) GCCGC(A/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RANGAP1 Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv915116 CNV Loss 21882294
nsv915117 CNV Loss 21882294
nsv915118 CNV Loss 21882294
nsv915119 CNV Loss 21882294
nsv459888 CNV Gain 19166990
nsv817997 CNV Gain 17921354
nsv516925 CNV Loss 19592680
nsv3637 CNV Loss 18451855
nsv915120 CNV Loss 21882294
nsv834207 CNV Loss 17160897
nsv3638 CNV Insertion 18451855

Variation tolerance for RANGAP1 Gene

Residual Variation Intolerance Score: 27.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RANGAP1 Gene

HapMap Linkage Disequilibrium report
RANGAP1
Human Gene Mutation Database (HGMD)
RANGAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANGAP1 Gene

Disorders for RANGAP1 Gene

Relevant External Links for RANGAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RANGAP1
genes like me logo Genes that share disorders with RANGAP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANGAP1 Gene

Publications for RANGAP1 Gene

  1. Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. (PMID: 7878053) Bischoff F.R. … Ponstingl H. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 23 67
  2. Influence of heart failure on nucleocytoplasmic transport in human cardiomyocytes. (PMID: 19819881) CortAcs R. … PortolAcs M. (Cardiovasc. Res. 2010) 23 67
  3. Analysis of in vitro SUMOylation using bioluminescence resonance energy transfer (BRET). (PMID: 19289109) Kim Y.P. … Kim H.S. (Biochem. Biophys. Res. Commun. 2009) 23 67
  4. Characterization of SENP7, a SUMO-2/3-specific isopeptidase. (PMID: 19392659) Shen L.N. … Hay R.T. (Biochem. J. 2009) 23 67
  5. Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. (PMID: 19285941) Zhu S. … Matunis M.J. (Mol. Cell 2009) 23 67

Products for RANGAP1 Gene

Sources for RANGAP1 Gene

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